Yazarlar
- Uzun, Sevda(79)
- Kulakaç, Nurşen(40)
- Turan, Ibrahim(33)
- Demir, Selim(32)
- Türkkan, Tuğba(24)
- Aydin, Aydanur(23)
- Topal, Fevzi(22)
- Aliyazicioglu, Yuksel(21)
- Tuncer, Metin(21)
- Bayrakdaroglu, Serdar(19)
- Demirağ, Hatice(19)
- Hintistan, Sevilay(18)
- Topal, Meryem(18)
- Yılmaz, Coşkun(18)
- Bayrakdaroğlu, Serdar(15)
- Yilmaz, Coskun(15)
- Mentese, Ahmet(14)
- Reis, Hatice Catal(14)
- Demir Doğan, Melike(13)
- Emirza, Elif Güzide(13)
- Memetoglu, Mehmet Erdem(13)
- Tuncer, Gülsüm Zekiye(13)
- Bülbül, Kenan(12)
- Cin, Aynur(12)
- Düzgün, Azer Özad(12)
- Koçak, Tevfik(12)
- Odaci, Hatice(12)
- Oğuzhan, Hatice(12)
- Tonkaz, Duygu Erkal(12)
- Tonkaz, Mehmet(12)
- Turk, Veysel(12)
- Ceylan, Halil Ibrahim(11)
- Kilinc, Kagan(11)
- Köse, Aslı(11)
- Merdan, Mehmet(11)
- Acet, Tuba(10)
- Aksoy, Bahar(10)
- Aydin Sayilan, Aylin(10)
- Baltaci, Cemalettin(10)
- Deger, Orhan(10)
Yayınlar
- MakaleYayıncıda açık erişim2025The Interactional Role of Dysfunctional Attitudes in the Relationship Between Religiosity and Existential
Ericek Maraslioglu, Serife
According to the findings of the Turkish General Social Survey (TGSS), feelings of loneliness are more prevalent among young people. Due to the frequent changes in values, emotions and thoughts that characterise individuals during this period of life, it can be said that they are particularly vulnerable to loneliness. Existential loneliness, a deeper form of loneliness, is also referred to as ultimate loneliness. Potential triggers for young individuals to experience existential loneliness include meaninglessness and the inability to make oneself understood or express one's feelings. However, loneliness has been associated with various mental and physical health problems, there is insufficient research on individuals experiencing existential loneliness during adolescence. Against this backdrop, the present study aims to examine the mediating role of dysfunctional attitudes in the relationship between religiosity and existential loneliness in individuals in early adulthood. Ethical approval for the study was granted by the G & uuml;m & uuml;& scedil;hane University Scientific Research and Publication Ethics Committee on 28/05/2025 (approval number 2025/5). The study included 408 participants (294 women and 114 men) aged between 18 and 29. Data were obtained using the Religiosity Scale, the Existential Loneliness Scale , and the Dysfunctional Attitudes Scale. These were analysed using IBM SPSS AMOS and the PROCESS add-on module for SPSS. Correlation analysis revealed that religiosity was negatively associated with existential loneliness and dysfunctional attitudes, while existential loneliness and dysfunctional attitudes were positively associated with each other. Additionally, the analyses revealed that dysfunctional attitudes played a mediating role in the relationship between religiosity and existential loneliness. The mediation analysis conducted within the scope of the study was performed using the PROCESS macro (Model 4). Interventions targeting dysfunctional attitudes and promoting a healthier self-concept/self-image could be crucial in safeguarding young adults against existential loneliness. These results shed light on potential psychological mechanisms that explain the effect of religiosity on loneliness experienced by young people.
- MakaleAçık Erişim2025Interactional Roles of Proactive Personality and Religious Attitude Levels in the Effect of Disappointment Intolerance on Mental Health of Earthquake Victims
Maraslioglu, Serife Ericek
Earthquakes, as natural disasters, are stressful life events characterized by frustration, uncertainty, and psychological burden. In fact, disappointment intolerance - the inability to tolerate distressing or obstructive experiences - has been shown to predict both life satisfaction and depressive symptoms. The present study aims to examine the mediating role of proactive personality in the relationship between disappointment intolerance beliefs and mental health, as well as the moderating role of religious attitudes in this relationship among earthquake victims living in container cities after the 6 February earthquakes. The participants were survivors residing in the region's most severely affected materially and morally by the earthquake centered in Kahramanmara & scedil;, T & uuml;rkiye. Data were collected from 354 individuals 18 months after the earthquake using the Demographic Information Form, Frustration Discomfort Scale, Proactive Personality Scale, Religious Attitude Scale, and Mental Health Scale. Pearson correlation, mediation, and moderation analyses were conducted. The findings indicated that higher levels of frustration intolerance were associated with increased levels of depression, anxiety, and stress. Furthermore, proactive personality was found to mediate the effect of disappointment intolerance subdimensions (entitlement, achievement, emotional intolerance, and discomfort intolerance) on mental health outcomes. However, religious attitudes did not moderate the negative impact of disappointment intolerance on depression, anxiety, and stress. The results are discussed considering existing literature, and implications for future research and intervention strategies are offered.
- MakaleYalnız künye2025POST-ACCIDENT RISK PERCEPTION, OCCUPATIONAL TRAUMAS, AND TRANSFORMATIONS IN PROFESSIONAL RESILIENCE: A PHENOMENOLOGICAL STUDY ON OCCUPATIONAL SAFETY SPECIALISTS IN THE MINING SECTOR
Dogan, Onur
This study aims to examine the occupational traumas experienced by occupational safety specialists following fatal, limb-loss, and serious injury-related workplace accidents, as well as the impact on their safety perceptions and the preventive strategies they develop. This research was conducted using a phenomenological approach, which is a type of qualitative research design. In-depth semi-structured interviews were carried out with 14 occupational safety experts working in various regions of Turkey. Criterion sampling was used to select participants. The data obtained were systematically analysed using thematic analysis. Interviews continued until data saturation was reached, and recurring patterns were observed. The research process and the reporting of findings were structured in accordance with the COREQ checklist. The study identified three main themes: occupational trauma, altered risk perception, and new safety strategies. These reflect specialistic psychological and professional changes following workplace accidents. The study offers insights into how occupational safety specialists adapt their policies and improve safety culture after serious accidents. It emphasises changes in precautionary approaches and their role in fostering safer workplaces. Key policy and cultural enhancement recommendations are also proposed.
- MakaleAçık Erişim2025The Effect of Hemodialysis Patients' Attitudes Towards Dietary Treatment on Dialysis Symptoms: A Randomized Controlled Clinical Study
Aktepe Cosar, Dilan; Demírag, Hatice
Objective: This study was conducted to determine the effect of hemodialysis patients' attitudes towards diet therapy on dialysis symptoms. Methods: The data of the randomized controlled study were collected from experimental (n=30) and control groups (n=30) at G & uuml;m & uuml;& scedil;hane Province Kelkit State Hospital between 1 November 2023 and 1 January 2024. Institutional and ethics committee permissions were obtained before the study. The experimental group patients were given training on diet therapy. Patient information form, hemodialysis patients' attitude scale towards diet therapy (HDTO) and dialysis symptom index (DSI) were used to collect data. Data collection tools were applied before the study (pre-test), after the training was given (intermediate measurement) and one month later (post-test). The data were analyzed using the chisquare, repeated measures ANOVA test and independent groups t-test in the SPSS 25.0 package program. Results: It was determined that the post-training measurements (intermediate measurement) of the total HDTO and sub-dimensions score averages of the hemodialysis patients in the experimental group were higher than the pre-training (pre-test) measurements; and the measurements made 1 month after the training (post-test) were lower than the measurements made immediately after the training (intermediate measurement) (p<0.05). Again, the post-training measurements (intermediate measurement) of the DSI score averages of the experimental group of patients were lower than the pre-training (pre-test) measurements (p<0.05); it was determined that the measurements made 1 month after the training were given (post-test) did not differ from the measurements made immediately after the training (intermediate measurement) (p>0.05). Conclusion: In line with the findings, it was determined that the diet therapy training provided increased hemodialysis patients' attitudes towards diet therapy and reduced dialysis symptoms.
- MakaleAçık Erişim2025Management of Major Arterial Injuries: A Critical Complication of Endoscopic Endonasal Surgery
Emengen, Atakan; Yilmaz, Eren; Gokbel, Aykut; Uzuner, Ayse; Cakir, Ozgur; Ciftci, Ercument; Ozsoy, Bedrettin; Ergen, Anil; Caklili, Melih; Cabuk, Burak
BACKGROUND AND OBJECTIVES:Endoscopic endonasal surgery (EES) is the preferred approach for treating sellar and parasellar lesions due to its panoramic view and detailed anatomical definition. This study aims to review major arterial injuries during EES, a rare but critical complication associated with high mortality and morbidity rates.METHODS:A retrospective analysis was conducted, including 15 patients from 5640 EES procedures performed between August 1997 and February 2024 at in our center/Department of Neurosurgery. The study focuses on perioperative and postoperative management strategies, highlighting the use of oxidized regenerated cellulose (Surgicel (R))/gelatin-thrombin matrix (Floseal (R)) and multidisciplinary collaboration to achieve hemostasis.RESULTS:The incidence of major arterial injury was 0.2%, with a mean patient age of 38.4 years and a female-to-male ratio of 10:5. The most common tumors were adenomas (n = 7) and chordomas (n = 5). The most commonly bleeding arteries in 6 patients each are the cavernous segment of the internal carotid artery and the paraclival carotid artery. Low-flow bleeding was observed in 10 of our patients, while high-flow bleeding was seen in 5 patients, 4 of whom were recurrent cases (P < .05). In 3 patients with high-flow bleeding from segments of the carotid artery, digital subtraction angiography was performed for stent placement or coil embolization, while in 1 patient with high-flow bleeding, digital subtraction angiography was used for monitoring cerebral blood flow. One of our patients died of a myocardial infarction at the 14th month of follow-up and 1 of our patients developed left-hemiparesis.CONCLUSION:The study underscores the importance of preoperative planning, surgical expertise, and multidisciplinary teamwork in managing major arterial injuries during EES. The authors advocate for the development of standardized treatment algorithms to improve outcomes in these patients. The findings contribute to the limited literature on managing internal carotid artery injuries in EES, emphasizing the need for ongoing research and algorithm development.
- Derleme MakaleAçık Erişim2025Purely endoscopic endonasal resection of extracranial trigeminal schwannomas: a descriptive systematic review and institutional case series
Yilmaz, Eren; Emengen, Atakan; Uzuner, Ayse; Ozsoy, Bedrettin; Gokbel, Aykut; Anik, Ihsan; Ceylan, Savas
Background: Trigeminal schwannomas (TSs) are uncommon, benign tumors that arise from the trigeminal nerve. They can spread to the middle cranial fossa, posterior fossa, and extracranially (pterygopalatine fossa (PPF), infratemporal fossa, orbita). Among these, extracranial involvement is the least frequent. Before the advent of endoscopic techniques, these tumors were primarily removed using conventional microsurgical approaches. Due to both the rarity of extracranial localization and the increasing use of endoscopic techniques in suitable cases, reports of TSs with extracranial involvement treated via a purely endoscopic endonasal approach (EEA) remain limited, typically appearing as case reports or a small subset within larger case series. This study systematically reviews the literature on extracranial TSs managed exclusively with EEA and presents two illustrative cases from our institution. Methods: A systematic search of the PubMed database was performed in accordance with PRISMA guidelines to identify studies that utilized a purely EEA for extracranial TS cases. Additionally, a retrospective review of 6118 EEA procedures conducted at our institution identified two patients with histopathologically confirmed extracranial TSs. Clinical presentation, surgical approach, outcomes, and complications were analyzed. Results: A total of 147 records were identified through database searches and reference lists. After removing duplicate records, 144 full-text articles were assessed for eligibility. Of these, 124 studies were excluded with justification, resulting in 23 studies being included in the review. When combined with our institutional cases, data from a total of 52 patients were analyzed. Facial numbness was the most common presenting symptom (70.5 %). The mean tumor diameter was 38.6 +/- 13.3 mm, and the gross total resection rate was 93.1 %. In our cases, both patients successfully underwent tumor resection via EEA without postoperative neurological deficits. Conclusions: EEA provides a direct, minimally invasive route for managing extracranial TSs while reducing the morbidity associated with transcranial approaches. Although optimal for purely extracranial tumors, lesions extending into the middle or posterior fossa may require a combined approach. Therefore, individualized surgical planning is essential for achieving optimal outcomes in TS management.
- MakaleYalnız künye2025Pan-immune-inflammation value predicts sustained ventricular arrhythmias in NSTEMI: a novel inflammatory risk marker
Sahin, Yusuf Bozkurt; Tanik, Veysel Ozan; Koçu, Gokturk Kaan; Özkan, Mehmet Taha; Akdogan, Murat; Seçkin, Ozden; Tunca, Cagatay; Sezgin, Ali; Akbuga, Kursat; Özlek, Bulent
BackgroundSystemic inflammation contributes to arrhythmogenesis in acute coronary syndromes, but its role in NSTEMI-related ventricular arrhythmias remains poorly defined. The pan-immune-inflammation value (PIV) is a novel composite biomarker reflecting immune and thrombotic activity derived from routine blood counts. This study aimed to assess the association between PIV and the risk of sustained VT/VF in NSTEMI.MethodsIn this retrospective cohort study, 1,788 NSTEMI patients who underwent percutaneous coronary intervention were analyzed. The primary endpoint was the occurrence of sustained VT or VF during hospitalization. PIV was calculated as (neutrophil x platelet x monocyte)/lymphocyte. Logistic regression, ROC analysis, Kaplan - Meier curves, reclassification indices (NRI, IDI), and restricted cubic spline modeling were used.ResultsVT/VF occurred in 34 patients (1.9%). Those with VT/VF had significantly higher PIV values (median 1132 vs. 329, p < 0.001). In multivariable analysis, PIV remained an independent predictor (OR: 1.356 per 1000 unit increase; 95% CI: 1.028-1.787; p = 0.031). The risk of VT/VF rose progressively across PIV quartiles (Q4 vs. Q1 OR: 4.0, p for trend < 0.001). Adding PIV to conventional predictors improved risk classification (NRI: +0.089; IDI: 0.007). Kaplan - Meier analysis showed significantly reduced arrhythmia-free survival in high-PIV tertiles (log-rank p < 0.001), and cubic spline modeling revealed a non-linear association with increased arrhythmic risk at higher PIV levels.ConclusionsElevated PIV is independently associated with malignant ventricular arrhythmias in NSTEMI. As an accessible biomarker, PIV may aid early arrhythmic risk stratification and guide clinical surveillance strategies.
- MakaleYayıncıda açık erişim2025A new method for the evaluation of cervical dystonia
Karakaya, Hanife; Colakoglu, Zafer; Acarer, Ahmet; Ozkurt, Ahmet
Objectives: The study aimed to develop a measurement method that yielded objective data for the clinical assessment of cervical dystonia using a Kinect camera system. Patients and methods: This double-blind, parallel-group method development study included 22 patients with cervical dystonia (3 males, 19 females; mean age: 47 years; range, 34 to 60 years) and 20 healthy individuals (13 females, 7 males; mean age: 32 years; age range, 22 to 65). Using cameras and a computer software, the head-neck postures of 40 healthy participants were recorded in the virtual environment. Using the device, 22 patients with cervical dystonia were examined both at rest and while moving with different parts of the body. Two different experts evaluated and scored the cases using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and the Tsui scale. Results: A three-way comparison revealed interclass correlations between the coefficients of 0.799 (79.9%) and 0.784 (78.4%) for at rest and with movement, respectively. The two-way comparison of the experts revealed correlation coefficients of 0.717 (71.7%) and 0.692 (69.2%) for at rest and with movement, respectively. A three-way comparison of the device and Expert 1 and Expert 2 TWSTRS scores revealed interrater agreement values of 0.6 and 0.8 (good) and 0.6 and 0.8 (good) while at rest and with movement, respectively. A three-way comparison of the device and Expert 1 and Expert 2 Tsui scores revealed interrater agreement values of 0.6 and 0.8 (good) and 0.4 and 0.6 (moderate) while at rest and with movement, respectively. Conclusion: The newly developed system was a sensitive tool for use in the kinematic evaluation of patients with cervical dystonia and could prove beneficial in diagnosis and treatment follow-up.
- MakaleAçık Erişim2025The Mediating Role of Impulsivity in the Relationship Between Internet Addiction and Eating Disorders: A Study on High School Adolescents
Bülbül, Kenan; Türkkan, Tugba; Meriç, Cagdas Salih; Yilmaz, Haci Omer
Eating disorders are a problem that negatively affects physical and psychological development and can potentially be life-threatening. In order to successfully combat this disorder, it is important to have a better understanding of the underlying mechanisms. The aim of this study is to examine the mediating role of impulsivity in the relationship between internet addiction and eating disorders in an adolescent sample. The current research was designed in accordance with the correlational model. The study group was formed by convenience sampling method among students who continue their education in secondary schools and high schools in Trabzon. The data of the study were collected with a demographic information form prepared by the researchers, the Young Internet Addiction Test-Short Form, Rezzy Eating Disorders Scale and Barratt Impulsivity Scale-Short Form. As a result of statistical analysis, it was determined that the average eating disorder score of female students was higher than that of male students. It was found that the eating disorder scores of those whose income was less than their expenses were significantly higher than those whose income was more than their expenses. Positive significant relationships have been identified between internet addiction and eating disorders. It has also been determined that impulsive behavior plays a mediating role in the relationship between internet addiction and eating disorders. It is thought that the current findings will contribute to the understanding of the mechanisms underlying eating disorders and the development of effective prevention and intervention strategies.
- MakaleAçık Erişim2025EFFECT OF TRAPEZIUS MUSCLE THICKNESS ON THE ONE-REPETITION MAXIMUM (1RM) STRENGTH
Yilmaz, Coskun; Ceylan, Tulay; Altunbas, Adem; Soylu, Hakan Huseyin; Kavuran, Korhan; Söyler, Mehmet
Purpose: The objective of this study was to examine the impact of trapezius muscle thickness measurements on bench press single repetition maximum (1RM) power output. Material and Methods: The study included 13 male bodybuilders who participated in national and international professional natural bodybuilding competitions and 13 healthy sedentary male subjects. Body composition, 1RM values and ultrasonographic measurements of trapezius muscle thickness were obtained from the participants. Results: The findings revealed that both the skin-to-superficial muscle tissue (R1, L1) and skin-to-deep fascia (R2, L2) distances were significantly lower in sedentary individuals compared to bodybuilders (p<0.001). Additionally, 1RM strength output was significantly higher in bodybuilders than in sedentary individuals. In sedentary individuals, a moderate negative correlation was observed between the distance between superficial muscle and 1RM, and a low positive correlation was observed between the distance between deep fascia and skin surface. In contrast, a low negative correlation was found in both parameters in bodybuilders. Conclusion: Our findings indicate that trapezius muscle thickness is significantly lower in sedentary individuals compared to bodybuilders, both in superficial and deep tissue layers. We believe that the skin surface imaging method used in our study could be an effective tool for predicting injuries in athletes. Additionally, we believe that regular imaging follow-ups in athletes could provide important information about adaptations in muscle structures resulting from applied training stimuli.
- MakaleAçık Erişim2025EZH2 expression in colorectal carcinoma: an evaluation of clinicopathological and prognostic value
Cagatay, Diren Vuslat; Balci, Mecdi Gurhan; Issin, Gizem; Demir, Fatih
BackgroundEnhancer of zeste homolog 2 (EZH2), the catalytic subunit of Polycomb Repressive Complex 2, catalyzes trimethylation of histone H3 lysine 27 and has been implicated in tumor progression.AimOur study aims to assess the relationship between EZH2 expression and clinicopathologic data, and survival in colorectal carcinomas (CRC).Materials and methodsEZH2 immunohistochemistry was performed on tumor blocks from 124 CRC patients. Based on H-scores, cases were stratified into low- and high-expression groups. EZH2 status was correlated with demographic, clinical, and pathologic features, and overall survival was analyzed with the Kaplan-Meier method and log-rank test.ResultsA total of 124 cases of CRC; 12 (9.7%) cases were classified as low EZH2 expression, and 112 (90.3%) cases were classified as high EZH2 expression. A significant association was found between EZH2 expression and microsatellite stability. High EZH2 expression was significantly enriched in microsatellite-stable tumors (p = 0.007) and in left-sided lesions (p = 0.049). No significant associations were detected with sex, stage, grade, lymph-node status, or vascular invasion. Kaplan-Meier analysis revealed no difference in overall survival between low- and high-EZH2 groups (log-rank p = 0.47; hazard ratio = 1.13, 95% CI 0.45-2.85). EZH2 staining was uniformly strong in normal mucosa and adenomas, mirroring the high expression observed in most CRCs.ConclusionsEZH2 is highly expressed across the normal-adenoma-carcinoma sequence and, in our cohort, was not linked to overall survival or to most clinicopathologic parameters in CRC. The lower expression observed in a subset of MSI-H tumors warrants further investigation; present evidence remains insufficient to establish EZH2 as an independent prognostic biomarker.
- MakaleAçık Erişim2025Investigation of Physical and Cognitive Performance of Athletes
Çeviker, Abdulkerim; Turgut, Abdusselam; Zambak, Omer; Yanar, Muhammed Said; Çamiçi, Furkan; Ünlil, Cisem; Eroglu, Seref
This study aims to examine the relationship between physical performance levels and cognitive functions of male athletes aged 18-25 years competing in the Turkish Hockey Indoor 1st League. 45 athletes participated in the study, balance, flexibility and vertical jump tests and D2 Attention Test were applied. In addition to descriptive statistics, independent samples t-test, one-way analysis of variance (ANOVA) and Pearson correlation analysis were used to analyze the data. The results revealed that attention levels did not differ significantly according to age, education, sport experience and position (p>0.05). While there was no significant relationship between physical performance variables and attention, only vertical jump values showed a significant difference between the positions (p<0.05). In addition, positive and significant correlations were observed between the sub-dimensions of the attention test. In this context, it was concluded that not only physical criteria but also cognitive skills should be systematically included in the performance evaluations of hockey athletes.
- MakaleAçık Erişim2025Measuring Dysfunctional Grief due to a COVID-19 Loss: A Kurdish Validation Study of the Pandemic Grief Scale
Karimi, Kambiz; Yaghoobi, Abolghasem; Gungor, Sunay; Karimi, Afagh; Sohrabi, Saeed
Millions of people are grieving the loss of someone who died of COVID-19. The current study aims to validate a Kurdish version of the Pandemic Grief Scale which is a brief English-language mental health screener to identify cases of dysfunctional grief associated with a COVID-19 death. We recruited 501 participants. Participants completed the PGS, WSAS, PHQ-9, and Optimism scales. The factor structure, reliability, and validity of the PGS were analyzed. Using exploratory factor analysis (N1 = 300), we derived an one-factor structure. In confirmatory factor analysis (N2 = 201), the one-factor model showed good to excellent fitness. The PGS was positively correlated with PHQ-4, and WSAS and negatively correlated with optimism. The scale was internally consistent with a Cronbach's alpha of .79. These results support that the Kurdish version of the PGS is a valid and reliable assessment to assess the severity of dysfunctional grief associated with a COVID-19 death.
- MakaleYalnız künye2025Phytochemical Profile, Antioxidant Capacity, Acetylcholinesterase, and Butyrylcholinesterase Enzyme Inhibition Properties of Myosotis amoena Boiss
Yapici, Ismail; Kayaoglu, Esma; Izol, Ebubekir; Yilmaz, Mustafa Abdullah; Behçet, Lutfi; Cakir, Oguz; Gülçin, Ilhami
Myosotis amoena Boiss. (Turkish name: Ho & scedil; boncukotu) is a perennial herbaceous plant that produces blue flowers during the spring. Phytochemicals, which are secondary metabolites distributed across plants, fungi, microorganisms, and even animal tissues, play crucial roles in health through their antioxidant and bioactive properties. Their antioxidant capacity largely arises from hydroxyl groups and aromatic ring structures that stabilize free radicals via electron delocalization. Enzyme inhibition is a therapeutic strategy in several diseases, including Alzheimer's disease (AD), where acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors are employed to manage symptoms. This study investigated the phytochemical composition (via LC-MS/MS), total phenolic content, antioxidant capacity, and AChE/BChE inhibitory effects of the ethanol extract of M. amoena using four in vitro methods. The CUPRAC assay demonstrated that M. amoena (1.070) exhibited higher antioxidant activity than Trolox (0.894), although its activity in FRAP, ABTS, and Fe3+ reduction assays was lower compared to standard antioxidants. The extract contained 53.03 mg GAE/g extract of total phenolics, with rosmarinic acid being the predominant compound (15.27 mg/g). Furthermore, the extract strongly inhibited AChE and BChE, with IC50 values of 3.9 and 19.8 mu g/mL, respectively. These findings highlight, for the first time, the significant bioactive potential of M. amoena as a natural source of antioxidants and cholinesterase inhibitors, supporting its prospective use in the prevention or management of neurodegenerative conditions.
- MakaleAçık Erişim2025The Relationship Between Thirst Distress and Severity and Compliance with Fluid Control and Interdialytic Weight Gain in Hemodialysis Patients
Cín, Aynur; Demírag, Hatice; Dastan, Buket; Híntístan, Sevilay
knowledge scores and FCHPS subscale attitude scores, and IDWG and FCHPS subscale attitude scores. A positive correlation was also found between the VAS score and IDWG. Conclusion: Thirst distress was higher than the moderate level in HD patients, and IDWG increased as thirst severity (VAS score) increased.knowledge scores and FCHPS subscale attitude scores, and IDWG and FCHPS subscale attitude scores. A positive correlation was also found between the VAS score and IDWG. Conclusion: Thirst distress was higher than the moderate level in HD patients, and IDWG increased as thirst severity (VAS score) increased.
- MakaleAçık Erişim2025DIAGNOSTIC CHALLENGE OF PRIMARY COLONIC POORLY COHESIVE ADENOCARCINOMA EXHIBITING GASTRIC-TYPE IMMUNOHISTOCHEMISTRY PROFILE AND FOCAL SIGNET-RING DIFFERENTIATION
ISSiN, Gizem; Tok, Merve; ÇAgATAY, Diren Vuslat; Gökçe, Oruc Numan; Aytekin, Faruk Onder
Colorectal adenocarcinoma infrequently exhibits a diffuse, poorly cohesive architecture and a gastric-type immunophenotype, closely resembling diffuse-type gastric carcinoma and posing a formidable diagnostic challenge. This report describes a 65-year-old woman who presented with non-specific abdominal discomfort and was found by colonoscopy to have a 6.5 cm ulceroinfiltrative lesion in the hepatic flexure. Histologically, the tumor comprised discohesive cells with focal signet-ring morphology, accompanied by extensive lymphovascular and perineural invasion, necrosis, and a marked peritumoral lymphoid response. Immunohistochemical analysis demonstrated a gastric-type profile (CK7+, CK20-, SATB2-, CDX2 weak/focal, MUC5AC+, MUC2-), whereas panels excluding breast, urothelial, M & uuml;llerian, neuroendocrine, and hematolymphoid differentiation were uniformly negative. Comprehensive imaging and endoscopic evaluation excluded an extra-colonic primary malignancy/ carcinoma. Mismatch repair testing revealed loss of MLH1/PMS2 expression with preserved MSH2/MSH6. This case underscores that, in such uncommon colorectal variants, reliance on immunophenotype alone may mislead, and that definitive diagnosis necessitates integrated clinicopathologic correlation, exhaustive sampling, and exclusion of alternative primaries/primary malignancies/carcinomas to confirm a primary colonic poorly cohesive adenocarcinoma with focal signet-ring differentiation.
- EditoryalYalnız künye2025Choroidal melanoma missed on brain MRI: Small lesion, big consequences
Tonkaz, Gokhan; Akdeniz, Cemre; Tonkaz, Mehmet; Tonkaz, Duygu Erkal
- MakaleAçık Erişim2025COMPARISON OF INSTANT EFFECT OF LUMBAL AND SACROILAC SPINAL MANIPULATION ON FLEXIBILITY AND JUMPING PERFORMANCE IN PROFESSIONAL SOCCER PLAYERS
Dönmez, Beyza; Hatik, Sefa Haktan; Büyükkirli, Ilker Can; Aydin, Emine Busra
Recent evidence suggests that spinal manipulation can acutely improve mobility and lower-limb performance. This study compared the acute effects of lumbar and sacroiliac chiropractic manipulation on flexibility nd jump performance. Forty-five healthy male participants were randomly assigned to three groups: a Lumbar Manipulation Group (LMG; n = 15), a Sacroiliac Manipulation Group (SMG; n = 15), and a Control Group (n = 15). Flexibility was assessed using the V-Sit and Reach test, while performance was evaluated with vertical and horizontal jump tests. Lumbar manipulation was applied to the dysfunctional lumbar segment in the LMG, and sacroiliac joint manipulation was applied to the dysfunctional sacroiliac region in the SMG. No intervention was performed in the control group. Both manipulation techniques resulted in significant acute improvements in mobility and jump performance compared with the control group (p < 0.05), with the greatest improvement observed in vertical jump height (p = 0.001). No significant differences were found between the LMG and SMG. Spinal manipulation to the lumbar and sacroiliac regions appears to produce acute improvements in mobility and lower-limb power. These findings suggest that spinal manipulation may serve as a short-term performance-enhancing intervention.
- MakaleAçık Erişim2025SOME PHYSICOCHEMICAL, COLOR, COOKING, BIOACTIVE AND SENSORY PROPERTIES OF TURKISH NOODLES: ENRICHED WITH ARONIA POWDER (ARONIA MELANOCARPA)
Karademir, Emine; Yuksel, Ferhat; Baltaci, Cemalettin
Aronia (Aronia melanocarpa) is a fruit with a high polyphenol content, and its use is increasing due to its potential health effects with increased polyphenol content. The widespread consumption of Turkish noodles and similar products in society is important for increasing their nutritional quality. The aim of this study was to evaluate the physicochemical, color, bioactive, and sensory properties of noodle samples to which aronia powder was added at different concentrations of 2%, 4%, 6%, 8%, and 10%, respectively. Total Polyphenol Content (TPC), Total Antioxidant Capacity (TAC), and Total Flavonoid Content (TFC) amounts were found to be significantly increased (p<0.05). In addition, significant increases were found in the antioxidant activity (ABTS(center dot+), DPPH and FRAP) of the samples. According to the sensory evaluations, the noodles with 8% aronia had a high level of general acceptability, while the group with 10% aronia had a lower level. Consequently, we observed that adding aronia could yield an acceptable noodle enriched in bioactive components.
- MakaleAçık Erişim2025First Aid Self-efficacy in Mothers of Children Aged 0-4 Years: The Gümüşhane Example
Göger, Berrin; Kahriman, Ilknur; Çolak, Bahar
Introduction: The high relationship between the effective application of first aid after home accidents and survival determines the priorities in first aid. Childcare is mostly the responsibility of mothers, and their knowledge and practices regarding the management of home injuries are crucial in reducing morbidity and mortality associated with home accidents. This study aimed to examine the first aid self-efficacy of mothers with children aged 0-4 years to manage their children's home accidents. Methods: This cross-sectional study, focusing on the first aid self-efficacy of mothers with children aged 0-4 for home accidents, was conducted with 266 mothers at a district government hospital affiliated with the Ministry of Health in the Eastern Black Sea Region between January 1, 2023, and August 1, 2023. Data were collected through a demographic information form and the first aid self-efficacy scale for home accidents. Results: The mean score of the first aid self-efficacy scale in home accidents was found to be 2.15 +/- 0.95 and significant differences were found according to the mother's level of education, number of children, income status, caregiver of the child and mothers' first aid status. Conclusion: In conclusion, the findings of the study showed that first aid self-efficacy is not based solely on demographic factors, but instead may be shaped more by education, experience and the general approach of parents as parents, although mothers' knowledge of first aid was below average.
