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- MakaleAçık Erişim2026Determinants of healthy orthorexia and orthorexia nervosa: the roles of food security, dietary behaviors, and obesogenic environment
Koçak, Tevfik; Arpa Zemzemoglu, Tuba Eda; Türkkan, Tugba; Bülbül, Kenan; Yilmaz, Birsen
Orthorexia has recently gained attention as a two-dimensional construct centered on a shared health orientation. Recent conceptual developments distinguish healthy orthorexia (HeOr), defined as a non-pathological interest in healthy eating, from orthorexia nervosa (OrNe), characterized by rigid and compulsive food control accompanied by psychological and social impairment. This cross-sectional study investigated the associations of HeOr and OrNe with sociodemographic variables, dietary behaviors, and obesogenic environmental factors, and aimed to identify shared and distinct determinants of these tendencies with 1,015 adults aged 18-65 years. Orthorexia tendencies were assessed using the Teruel Orthorexia Scale. Additional measures included the Sustainable and Healthy Eating Behaviors Scale, Short Screening Questionnaire of Highly Processed Food Consumption, Adult Food Security Survey Module, Food Label Reading Attitude Scale, Food Choice Questionnaire, and the Obesogenic Environment Assessment Scale. In the adjusted regression models, HeOr was positively associated with sustainable and healthy eating behaviors (beta = 0.26), AFSS food-insecurity severity score (beta = 0.11), food label reading attitudes (beta = 0.07), health-related food choice motives (beta = 0.09), natural-ingredient preference (beta = 0.14), weight-control motives (beta = 0.15), ethical food choice motives (beta = 0.10), and obesogenic social determinants and effects (beta = 0.09). Conversely, affordability-related motives (beta = -0.08), emotional appeal (beta = -0.15), familiarity (beta = -0.10), and obesogenic cultural determinants/access to experts (beta = -0.12) were negatively associated with HeOr. For OrNe, positive associations were observed with sustainable and healthy eating behaviors (beta = 0.13), AFSS food-insecurity severity score (beta = 0.17), mood-related food choice motives (beta = 0.13), weight-control motives (beta = 0.26), familiarity (beta = 0.09), ethical food choice motives (beta = 0.18), and obesogenic social determinants and effects (beta = 0.30), whereas health-related food choice motives (beta = -0.12), affordability-related motives (beta = -0.08), and emotional appeal (beta = -0.24) showed negative associations. These findings suggest that orthorectic tendencies are associated with individual health motivations as well as broader behavioral and environmental contexts; however, because of the cross-sectional design, these associations should be interpreted as correlational and hypothesis-generating rather than causal.
- Derleme MakaleAçık Erişim2026Intersection of Precision Nutrition and Bladder Cancer: A Narrative State-of-the-Art Review of Potential Applications and Challenges
Koçak, Tevfik; Özbek, Yağmur Demirel; Bodur, Mahmut; Yeşil, Süleyman; Ağagündüz, Duygu
Bladder cancer (BC) is a biologically heterogeneous tumor affected by genetic, metabolic, environmental, and lifestyle factors. Recent research indicates that nutrition can change the way urothelial cancer forms by affecting inflammation, oxidative stress, cellular energy, and the epigenome. It can also change the risk of BC and how well treatment works. Simultaneous progress in precision nutrition (PN) and nutriomic profiling—encompassing nutrigenomics, nutrigenetics, nutriepigenetics, metabolomics, and microbiome science—presents novel options to tailor dietary regimens beyond universal guidelines. In this review, we consolidate existing knowledge regarding the nutritional factors influencing BC, outline pertinent principles of PN for BC prevention and survival, and explore how urine proteomics and molecular subtyping facilitate the integration of PN into precision oncology. Our review examines the methodological, bioinformatic, biomarker, and clinical translation challenges that impede the implementation of PN in BC management; these challenges include the need for validated nutritional biomarkers with mechanistic endpoints, interoperable data platforms, and rigorously designed clinical trials. Finally, we emphasize future prospects for PN-guided medical nutrition therapy and dietary models during and after systemic treatment recovery. We propose research priorities that will facilitate the integration of PN-informed individualized dietary plans with medical and surgical approaches in BC treatment, aiming to decrease the costs associated with expensive or excessively aggressive treatment methods, thereby supporting long-term survival care. This review seeks to establish a conceptual framework for the integration of PN into BC management by delineating the opportunities and challenges, hence promoting hypothesis-driven research in a promising yet underexplored domain.
- MakaleAçık Erişim2026Assessment of the effect of conventional and contemporary drying methods on the phenolic profile modulation and antioxidant retention of Trabzon persimmon (Diospyros kaki L.)
Koçak, Tevfik; Demirel Ozbek, Yagmur; Saral, Ozlem; Kocyigit, Emine
This study investigated the effects of conventional and modern drying methods on the total phenolic content, antioxidant activity, and phenolic compound composition of Trabzon persimmons (Diospyros kaki L.) fruits harvested from the same tree and at comparable maturity stages were subjected to sun drying, shade drying, oven drying, air-fryer drying, and microwave drying techniques, with raw samples serving as the control group. The total phenolic content was assessed via the Folin–Ciocalteu method, and the antioxidant capacity was evaluated using the ferric reducing antioxidant power (FRAP) and DPPH radical scavenging activity assays. The identification and quantification of phenolic compounds were conducted using the HPLC technique. The results indicated that the drying process produced statistically significant variations in the phenolic content and antioxidant capacity of Trabzon persimmons. The microwave drying technique resulted in highest total phenolic content and antioxidant activity, whereas both sun and shade drying procedures showed higher values than raw samples. The total phenolic content and antioxidant capacity of samples dried in an air fryer were found to be comparable to those of raw samples. The profile of phenolic compounds varied according to the drying process employed; certain compounds exhibited an increase with specific methods, while others were identified solely under particular conditions. Thus, it has been shown that drying techniques can have a significant impact on preserving and improving the functional properties of persimmons. Furthermore, we believe that microwave drying could be an effective alternative, particularly in terms of preserving bioactive compounds.
- MakaleAçık Erişim2026Adherence to the MIND Diet and Its Effect on Glycemic Parameters in Patients with Type 2 Diabetes: A Cross-Sectional Study; [Tip 2 Diyabetlilerde MIND Diyetine Uyumun Glisemik Parametreler Üzerindeki Etkisi: Kesitsel Bir Çalışma]
Koçyiğit, Emine; Koçak, Tevfik; Özbek, Yağmur Demirel
Aim: This study aimed to assess the relationship between Mediterranean-Dietary Approach to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet score and indicators of glucose control and lipid metabolism in patients with type 2 diabetes mellitus. Methods: This cross-sectional study involved 459 patients diagnosed with type 2 diabetes mellitus aged 20-64 years. Patients with type 2 diabetes mellitus completed a general information form and anthropometric measures. The MIND diet scores obtained from the MIND diet components form. The biochemical parameters gathered from individuals over the last three months were documented. Results: The mean age and body mass index in the study population were 49.10±10.10 years and 30.62±5.48 kg/m2. Overall, the mean MIND diet score was 8.64±1.75, and 47.10% had high adherence to the MIND diet. A significant difference was found between HbA1c and fasting plasma glucose (FBG) in the MIND groups, as well as a substantial negative association identified among HbA1c, FBG, and MIND scores. Conclusions: This study emphasized the significant incidence of overweight and obesity among Turkish adults with type 2 diabetes mellitus. Higher adherence to the MIND diet is associated with better glycemic control. Higher MIND diet scores associated with reduced HbA1c and FBG levels. However, no significant associations with the parameters of lipid metabolism were found. By emphasizing nutrient-dense foods and supporting both metabolic and psychological health, the MIND diet may represent a valuable adjunct to conventional diabetes management. Keywords.
- MakaleAçık Erişim2026Weight self-stigma, weight bias internalization, and eating attitudes in relation to body appreciation
Koçak, Tevfik; Kocyigit, Emine; Demirel Ozbek, Yagmur; Celik, İsa
Objective: This study aimed to investigate the relationships between weight self-stigma, weight bias internalization, eating attitudes, and body appreciation in young adults, and to ascertain the distinct impact of these variables on body appreciation. Methods: A cross-sectional study was carried out including young adults aged 19 to 35 years, comprising 69.6% females and 30.4% males. Participants completed a questionnaire evaluating weight self-stigma, internalization of weight bias, eating attitudes, and body appreciation. Hierarchical multiple regression analyses were used to assess the additional impacts of weight-related stigma and eating attitudes on body appreciation, while adjusting for demographic and anthropometric factors. Results: Weight self-stigma, particularly the internalization of weight bias, showed a significant negative association with body appreciation. Weight self-stigma and its subdimensions (self-devaluation and fear of enacted stigma) had substantial negative correlations with body appreciation. These correlations encompassed the subdimensions of body appreciation, specifically general body appreciation and body image investment. While eating attitudes did not show a significant correlation with body appreciation at the bivariate level, they became a significant predictor in the hierarchical regression model, suggesting a conditional (suppression) effect after accounting for weight-related stigma and BMI. Conclusion: The findings emphasize the important function of weight-related stigma in diminishing body appreciation among young adults and stress the necessity of examining eating attitudes in conjunction with stigma-related factors. Interventions designed to enhance positive body image should focus on both internalized weight stigma and maladaptive eating-related attitudes.
- MakaleYayıncıda açık erişim2025Validity and reliability of the Turkish version of the chrono-med diet score (CMDS) for adult participants
Koçak, Tevfik; Kocyigit, Emine; Ağagündüz, Duygu
Background: This study aimed to examine the validity and reliability of the Chrono-Med Diet Score (CMDS) to assess adherence to the Mediterranean diet in Turkish adults. Methods: The methodological research conducted in Gümüşhane and Ordu from January to June 2024, including 592 individuals (62.3% women, 37.7% men, and the mean age 43.4 ± 10.6 years). Data were collected through face‒to‒face interview that contained socio-demographic characteristics, the CMDS, the Mediterranean Diet Adherence Screener (MEDAS), and 24-h dietary recall. Internal consistency reliability was assessed using Cronbach’s alpha coefficient, while repeatability was examined using the test–retest method. Construct validity was assessed by the MEDAS, and components of the adapted CMDS obtained from the 24-h dietary recall were analyzed using confirmatory factor analysis. The content validity was assessed by the Paired samples t-test and Wilcoxon test. The Bland–Altman test with 95% limits of agreement was used to evaluate the agreement between sum of CMDS. The results were statistically evaluated at a p < 0.05 significance level. Results: The content validity index of CMDS was 0.87. The overall Turkish version of CMDS had acceptable internal consistency (Cronbach’s α = 0.853), thus indicating that the score was reliable. The Paired samples t test coefficients between each item and the overall questionnaire ranged from 0.234 to 1.000. A higher intake of olive oil and fish obtained from a 24-h dietary recall was associated with a higher CMDS quartile (p < 0.05). The MEDAS score was correlated with a higher CMDS quartile (p < 0.001). A moderate positive correlation was determined between total CMDS and MEDAS (r = 0.467; p < 0.001). Conclusions: Our assessments of the CMDS, consisting of 13 items, in Türkiye demonstrate that it is a viable and reliable instrument to measure adherence to the Mediterranean diet for the adult population. The CMDS is more accurate than other Mediterranean diet scores as it questions about the amount of physical activity and grain products, which helps determine each participant’s eating patterns and general health.
- MakaleAçık Erişim2025The Correlation Between Circulating Fetuin-A Levels and Fetuin-A to Adiponectin Ratio With Obesity in a Turkish Population: A Case-Control Study
Icer, Mehmet Arif; Koçak, Tevfik; Ağagündüz, Duygu; Yıldıran, Hilal
The relationship between serum fetuin-A levels and obesity has not been fully understood. This study aims to elucidate the levels of serum fetuin-A and F/A ratio in obesity and contribute to the literature on whether they could be novel clinical predictors modulated through body composition and nutrition. The study included 73 participants who were obese and 71 participants with normal weight, aged between 18 and 65 years. Certain anthropometric measurements of the individuals were taken, and a body composition analysis was performed. In addition, 3-day food records (consecutive days: 2 weekdays and one weekend day) were taken. Serum levels of fetuin-A (ng/mL) and adiponectin (μg/mL) were measured using an enzyme-linked immunosorbent assay (ELISA) method. The F/A ratio was obtained by dividing fetuin-A (ng/mL) by adiponectin (μg/mL). Serum fetuin-A (ng/mL) level and F/A ratio are higher in obese participants than in normal weight (p < 0.05). Body weight (kg) (r = 0.553, p ≤ 0.001), body mass index (kg/m2) (r = 0.492, p ≤ 0.001), waist circumference (cm) (r = 0.522, p ≤ 0.001), body fat percentage (%) (r = 0.203, p = 0.015), serum fasting blood glucose levels (mg/dL) (r = 0.317, p ≤ 0.001), and dietary protein intake (kg) (r = 0.165, p = 0.048) were observed to be positively correlated with serum fetuin-A levels. Positive correlations were also observed between these parameters and the F/A ratio (p < 0.05). Negative correlations were found between serum adiponectin and these parameters (p < 0.05). In addition, when dietary cholesterol intake was kept constant, a 1-unit increase in dietary energy intake (kcal) resulted in a 0.043-fold increase in serum fetuin-A (p < 0.05). The study results support theories suggesting the involvement of serum fetuin-A levels and the F/A ratio in the pathogenesis of obesity. The higher serum fetuin-A levels and F/A ratio found in obese participants may be considered as new clinical determinants that could be regulated through body composition and nutrition.
- MakaleAçık Erişim2025A novel equation synthesis for estimating resting energy expenditure in prostate cancer patients
Tek, Nilüfer Acar; Koçak, Tevfik; Yeşil, Süleyman; Sözen, Tevfik Sinan
Background: An accurate calculation of energy expenditure (REE) is necessary for estimating energy needs in malign prostate cancer. The purpose of this research was to evaluate the accuracy of the established novel equation for predicting REE in malign and benign prostate patients versus the accuracy of the previously used predictive equations based on REE measured by indirect calorimetry. Methods: The study was conducted as a cross-sectional case-control study and between December 2020 and May 2021 with 40 individuals over the age of 40 who applied to the Urology Clinic of Gazi University Faculty of Medicine. Subjects with 41 malign prostate and 42 benign prostate patients were both over the age of 40 (65.3 ± 6.30 years) and recruited for the study. Cosmed-FitMate GS Indirect Calorimetry with Canopyhood (Rome, Italy) was used to measure REE. A full body composition analysis and anthropometric measurements were taken. Clinical trial number: Not applicable. Results: Malign prostate group PSA Total and measured REE values (4.93 ± 5.44 ng/ml, 1722.9 ± 272.69 kcal/d, respectively) were statistically significantly higher than benign group (1.76 ± 0.73 ng/ml, 1670.5 ± 266.76 kcal/d, respectively) (p = 0.022). Malign prostate group (MPG) and benign prostate group (BPG) have the highest percentage of the accurate prediction value of Eq. 80.9% (novel equation MPG) and 64.2% (novel equation BPG). The bias of the equations varied from − 36.5% (Barcellos II Equation) to 19.2% (Mifflin-St. Jeor equation) for the malign prostate group and varied from − 41.1% (Barcellos II Equation) to 17.7% (Mifflin-St. Jeor equation) in the benign prostate group. The smallest root mean squared error (RMSE) values in the malign and benign prostate groups were novel equation MPG (149 kcal/d) and novel equation BPG (202 kcal/d). The new specific equation for malign prostate cancer: REE = 3192,258+ (208,326* body weight (WT)) - (20,285* height (HT)) - (187,549* fat free mass (FFM)) - (203,214* fat mass (FM)) + (4,194* prostate specific antigen total (PSAT)). The new specific equation for the benign prostate group is REE = 615,922+ (13,094*WT). Bland-Altman plots reveal an equally random distribution of novel equations in the malign and benign prostate groups. Conclusions: Previously established prediction equations for REE may be inconsistent. Utilising the PSAT parameter, we formulated novel energy prediction equations specific to prostate cancer. In any case, the novel predictive equations enable clinicians to estimate REE in people with malign and benign prostate groups with sufficient and most acceptable accuracy.
- MakaleAçık Erişim2025Low Serum and Urine Fetuin-A Levels and High Composite Dietary Antioxidant Index as Risk Factors for Kidney Stone Formation
Icer, Mehmet Arif; Koçak, Tevfik; Icer, Yusuf; Kocyigit, Emine; Agagündüz, Duygu; Gezmen-Karadag, Makbule; Yesil, Suleyman; Budán, Ferenc
Background: Fetuin-A prevents the precipitation of hydroxyapatite in supersaturated solutions of calcium and phosphate; however, its relationship with nephrolithiasis has yet to be clarified. The aim of this study was to investigate the protective and predictive roles of serum and urine fetuin-A levels in nephrolithiasis and their relationships with the composite dietary antioxidant index (CDAI). Methods: This study involved 75 adult patients with kidney stone disease and 71 healthy adults without kidney stone disease in the control group. Participants had specific anthropometric measurements taken, and three-day food records were kept. The CDAI was calculated by summing six standard antioxidants, including vitamins A, C, and E, manganese, selenium, and zinc, representing participants' antioxidant profile. In addition to some analyzed serum and urine parameters of the participants, fetuin-A levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Results: In patients with kidney stones, both serum and urine fetuin-A levels (676.3 +/- 160.14 ng/mL; 166.6 +/- 128.13 ng/mL, respectively) were lower than in the control group (1455.6 +/- 420.52 ng/mL; 2267.5 +/- 1536.78 ng/mL, respectively) (p < 0.00001). In contrast, the CDAI was higher in patients with kidney stones compared to those without kidney stones (p < 0.001). Besides, several dietary parameters had significant positive correlations with serum and/or urinary fetuin-A. Conclusions: The present study suggests that serum and urinary fetuin-A levels may serve as protective factors against kidney stones and could potentially be used as predictive markers for the development of nephrolithiasis. Furthermore, our results suggest that the CDAI above a certain level may increase the risk of stone formation and that some dietary parameters may affect the levels of this biomarker in serum and urine.
- MakaleYayıncıda açık erişim2025Serum neopterin and kynurenine as predictive and prognostic biomarkers in prostate cancer: the role of dietary inflammatory index and biomarker interactions
Icer, Mehmet Arif; Koçak, Tevfik; Acar-Tek, Nilufer; Yesil, Suleyman; Icer, Yusuf
Background It has been shown that neopterin levels in various body fluids can help predict the diagnosis of different malignancies. Although many studies have investigated the roles of serum neopterin concentrations, tryptophan metabolism, and the dietary inflammation index (DII) in various cancers, the connection between these factors and prostate cancer (PC) remains uncertain. The aim of this study was to investigate the predictive and prognostic roles of serum neopterin, and kynurenine levels, along with the kynurenine-to-tryptophan ratio (KTR) and DII in prostate cancer. Methods This study was conducted with 57 newly diagnosed prostate cancer patients, 55 benign prostate hyperplasia patients, and 56 healthy male individuals in the control group, all aged 40 years and older. Participants had specific anthropometric measurements taken, and three-day food records were kept. DII was calculated based on data for thirty-four available nutrients by using food records. Serum levels of neopterin, kynurenine, tryptophan, tumor necrosis factor alpha (TNF-alpha), and interferon-gamma (IFN-gamma) were measured using an enzyme-linked immunosorbent assay (ELISA) method. Results Serum neopterin (11.79 +/- 6.09), kynurenine (1655.48 +/- 1122.04), TNF-alpha (221.59 +/- 232.06) and IFN-gamma (137.68 +/- 107.11) levels were higher in the malignant group than in both the control (2.72 +/- 0.76, 352.40 +/- 69.33, 223.94 +/- 226.67, and 23.03 +/- 7.28, respectively) and benign groups (3.17 +/- 0.74, 377.94 +/- 109.05, 179.61 +/- 224.36, and 25.63 +/- 7.50, respectively) (p < 0.05). Another result of our study is that in the malignant group, serum neopterin levels exhibited significant positive correlations with serum kynurenine (r = 0.80, p < 0.0001), IFN-gamma (r = 0.86, p < 0.0001) and TNF-alpha levels (r = -0.27, p = 0.0453) and DII (r = 0.30, p = 0.0229), while they exhibited weak correlations with serum PSA, and other diet parameters. Additionally, kynurenine was the only parameter showing significant differences in mean values concerning surgical margins (p < 0.05). Conclusions The findings of this study support the hypothesis that serum neopterin and specific tryptophan catabolites (e.g., kynurenine), could serve as predictive and prognostic biomarkers for prostate cancer diagnosis. However, our results do not support the hypothesis that DII and certain dietary factors play a direct role in the development or diagnosis of prostate cancer.
- MakaleAçık Erişim2025Could GSTP1, PTEN and NKX3.1 gene expression be novel markers in the relationship between prostate cancer and epigenetics?
Koçak, Tevfik; Acar-Tek, Nilufer; Yesil, Suleyman; Ergün, Mehmet Ali; Icer, Yusuf
Background: Although numerous treatment modalities exist for Prostate Cancer (PCa) with a complex pathophysiology, a significant worldwide health concern for males, early identification remains the paramount factor influencing disease prognosis. Proposed new biomarkers, including GSTP1, PTEN, and NKX3.1, may provide predictive and prognostic functions, hence enhancing the efficacy of PSA in diagnosing prostate cancer. Epigenetic variables associated with nutrition influence the blood gene expression levels of the new biomarkers GSTP1, PTEN, and NKX3.1. This study aimed to elucidate the correlation between nutrition-related epigenetic variables and the expression of the tumor suppressor genes GSTP1, PTEN, and NKX3.1 in benign prostate and prostate cancer patients. Methods: This study was conducted with 41 newly diagnosed prostate cancer and 42 benign prostate patients, all aged 40 years and older. Participants had specific anthropometric measurements taken, and seven-day food records were kept. Serum levels of novel biochemical markers GSTP1, PTEN, and NKX3.1 were measured using an Enzyme-Linked Immunosorbent Assay (ELISA) method. Expression analyses of tumor-protective GSTP1, PTEN, and NKX3.1 genes were performed on prostate tissues obtained from fresh prostate biopsies taken from the groups and were associated with nutritional status. Results: A significant relationship was found between the serum levels of GSTP1, PTEN, and NKX3.1, which are important in the formation and treatment of prostate cancer, and Gleason grade, tumor stage, and surgical margin status (p < 0.05). However, significant relationships were found between many macro and micronutrients obtained from the dietary pattern and effective in epigenetic pathways and GSTP1, PTEN, and NKX3.1 gene expressions (p < 0.05). Conclusions: The findings of this investigation corroborated the notion that prospective novel markers, including GSTP1, PTEN, and NKX3.1, may serve predictive and prognostic functions in prostate cancer, hence enhancing the efficacy of PSA in its diagnosis. Dietary trends may influence the optimization of many epigenetic processes. Targeted therapeutic nutritional interventions designed to enhance gene expression will facilitate the formulation of prostate cancer prevention methods.
- Derleme MakaleAçık Erişim2024Oxylipins Derived from PUFAs in Cardiometabolic Diseases: Mechanism of Actions and Possible Nutritional Interactions
Ağagündüz, Duygu; Yeşildemir, Özge; Koçyiğit, Emine; Koçak, Tevfik; Özen Ünaldı, Buket; Ayakdaş, Gamze; Budán, Ferenc
Oxylipins are oxidized fatty acids, both saturated and unsaturated, formed through pathways that involve singlet oxygen or dioxygen-mediated oxygenation reactions and are primarily produced by enzyme families such as cyclooxygenases, lipoxygenases, and cytochrome P450. These lipid-based complex bioactive molecules are pivotal signal mediators, acting in a hormone-like manner in the pathophysiology of numerous diseases, especially cardiometabolic diseases via modulating plenty of mechanisms. It has been reported that omega-6 and omega-3 oxylipins are important novel biomarkers of cardiometabolic diseases. Moreover, collected literature has noted that diet and dietary components, especially fatty acids, can modulate these oxygenated lipid products since they are mainly derived from dietary omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) or linoleic acid and α-linolenic by elongation and desaturation pathways. This comprehensive review aims to examine their correlations to cardiometabolic diseases and how diets modulate oxylipins. Also, some aspects of developing new biomarkers and therapeutical utilization are detailed in this review.
- Derleme MakaleYayıncıda açık erişim2024From Garden to Pillow: Understanding the Relationship between Plant-Based Nutrition and Quality of Sleep
Arslan, Neslihan; Bozkır, Eda; Koçak, Tevfik; Akin, Meleksen; Yilmaz, Birsen
The effect of diet on sleep quality has been addressed in many studies; however, whether/how plant-based diets (PBDs) impact sleep-related parameters has not been explored in detail. This review aims to give an overview of the components of PBDs and the possible mechanisms through which PBDs may improve sleep quality. Studies have indicated that diets such as PBDs, which are typically high in fruits, vegetables, nuts, seeds, whole grains, and fiber, are associated with better sleep outcomes, including less fragmented sleep and improved sleep duration. Several mechanisms may explain how PBDs impact and/or improve sleep outcomes. Firstly, PBDs are characteristically rich in certain nutrients, such as magnesium and vitamin B6, which have been associated with improved sleep patterns. Secondly, PBDs are often lower in saturated fats and higher in fiber, which may contribute to better overall health, including sleep quality. Additionally, plant bioactive compounds like phytochemicals and antioxidants in fruits, vegetables, and herbs may have sleep-promoting effects. According to available data, PBD and Mediterranean diet elements promise to enhance sleep quality; however, it is crucial to note that diets should be customized based on each person’s needs.
- Derleme MakaleAçık Erişim2024Decoding coffee cardiometabolic potential: Chemical composition, nutritional, and health relationships
Karagöz, Mustafa Fevzi; Koçyigit, Emine; Koçak, Tevfik; Sirin, Aycil Ozturan; Icer, Mehmet Arif; Agagündüz, Duygu; Coreta-Gomes, Filipe
Coffee is one of the most consumed beverages worldwide, recognized for its unique taste and aroma and for its social and health impacts. Coffee contains a plethora of nutritional and bioactive components, whose content can vary depending on their origin, processing, and extraction methods. Gathered evidence in literature shows that the regular coffee consumption containing functional compounds (e.g., polysaccharides, phenolic compounds, and melanoidins) can have potential beneficial effects on cardiometabolic risk factors such as abdominal adiposity, hyperglycemia, and lipogenesis. On the other hand, coffee compounds, such as caffeine, diterpenes, and advanced glycation end products, may be considered a risk for cardiometabolic health. The present comprehensive review provides up-to-date knowledge on the structure-function relationships between different chemical compounds present in coffee, one of the most prevalent beverages present in human diet, and cardiometabolic health.