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- Uzun, Sevda(79)
- Kulakaç, Nurşen(40)
- Turan, Ibrahim(33)
- Demir, Selim(32)
- Türkkan, Tuğba(24)
- Aydin, Aydanur(23)
- Topal, Fevzi(22)
- Aliyazicioglu, Yuksel(21)
- Tuncer, Metin(21)
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- Bayrakdaroğlu, Serdar(15)
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- Mentese, Ahmet(14)
- Reis, Hatice Catal(14)
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- Memetoglu, Mehmet Erdem(13)
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- Bülbül, Kenan(12)
- Cin, Aynur(12)
- Düzgün, Azer Özad(12)
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- Ceylan, Halil Ibrahim(11)
- Kilinc, Kagan(11)
- Köse, Aslı(11)
- Merdan, Mehmet(11)
- Acet, Tuba(10)
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- Deger, Orhan(10)
Yayınlar
- MakaleAçık Erişim2025As if I don't belong here. First-Year Experiences of International Nursing Students at University - A Qualitative Study
Tuncer, Gulsum Zekiye; Tuncer, Metin
Background: The rapid adaptation of international nursing students to university life enables them to actively continue their education without disruption in the following years. Identifying the challenges faced by these students, who are future nursing professionals, is essential fortheir adaptation and professional development. Aim: This study aimed to explore the perspectives of international nursing students regarding their first-year experiences at university. Methods: This study employed a descriptive qualitative research design. The Consolidated Criteria for Reporting Qualitative Research (COREQ) was used for reporting. The sample consisted of 13 international nursing students enrolled in the Faculty of Nursing at a university. Data were collected through face-to-face, individual, in-depth interviews using semi-structured interview questions. Content analysis was used to analyze the data. Results: The mean age of the nursing students was 23.3 years. Among the participants, seven were women, 11 had been residing in Turkiye for approximately one year, 12 were from Iran, and one was from Iraq. Three key themes emerged in this study: Facilitators of Adaptation, Challenges, and Coping. The students identified several facilitators of adaptation, including similarities between the Turkish economy and culture and their home countries' economies and cultures, proficiency in the Turkish language, studying at a nursing school aligned with their career goals, and receiving social support from their relatives. However, they also faced challenges such as language barriers, cultural differences, discrimination, social isolation, homesickness, and academic and clinical difficulties. Conclusion: International nursing students may encounter language barriers, cultural differences, and education-specific challenges during their first year of nursing school. In this context, developing support mechanisms to guide these students in their academic and social lives will facilitate their ability to cope with these difficulties.
- MakaleYayıncıda açık erişim2025A structured educational model to improve the education of nurses: Case-based learning
Aydın, Aydanur
Background: Case-based training is a crucial component of nursing education, providing students with opportunities to enhance clinical reasoning, critical thinking, and professional behavior. However, few studies integrate these constructs into measurable educational outcomes. Methods: This study aims to look at the influence of online care training, which is based on case studies in surgical illnesses nursing, on students' care behaviors and self-efficacy levels. Participants were randomly assigned to undergo case-based education or traditional instruction. One hundred and four undergraduate nursing students from one university were chosen to participate. The structure is logical, with causal relationships between claims and a clear order of information. The researcher used an online platform to collect data from students in both groups before and three months after training. The introduction features form comprised the caring behavior scale (CBS) and questions to assess nursing students' self-efficacy. Results: Before the training, there was no discernible difference in the levels of care exhibited by the participants or in their self-efficacy. Nevertheless, a notable alteration was observed in the CBS scores of the intervention group students following the training period. Their CBS and self-efficacy scores surpassed those of the control group. The results of the regression analysis indicated that age, gender, place of residence, and caring assessment scores did not exert a significant influence on the total score of the Caring Behavior Scale. Conclusion: The findings of the research indicated that structured case-based nursing education was an effective method for fostering the development of caring behaviors among students.
- MakaleAçık Erişim2025The Protective Effect of Boric Acid Against High Fructose-Induced Liver and Kidney Damage in Rats
Yüksel, Duygu; Başeğmez, Mehmet; Kan, Fahriye
This study aimed to determine the protective role of boric acid (BA) in high fructose (HF)-induced liver and kidney toxicity in a young rat model. High-fructose consumption causes serious damage to liver and kidney tissue in healthy individuals and contributes to the emergence of various metabolic diseases. Thirty-two healthy female Wistar albino rats (250–300 g weight and 3–4 months) were randomly distributed into four equal groups (n = 8): control, high fructose % 20 (HF), boric acid 20 mg/kg (BA), and HF + BA. High fructose was freshly prepared and administered to the rats as 20 g of d-fructose dissolved in 100 mL of tap water daily for a duration of 30 days. Boric acid (20 mg/kg) was administered through gastric gavage throughout the 30-day study period. At the end of study, blood, liver, and kidney were collected from rats. The results indicated that high fructose induced increased glucose, total cholesterol, triglyceride, and urea levels in rat serum. Boric acid administration significantly decreased glucose, total cholesterol, triglyceride, and urea levels in HF + BA groups. The results indicated that high fructose-induced oxidative stress by increasing the level of MDA and by decreasing GSH levels, and CAT activity in the liver and kidney of rats. However, oral BA administration significantly decreased MDA levels and increased GSH levels, and CAT activity (p < 0.05). Furthermore, BA significantly reduced high fructose-induced histopathological and Immunohistochemistry alteration in the liver and kidney tissues. In conclusion, BA may prevent the oxidative imbalance and histopathological and immunohistochemical damage caused by high fructose in liver and kidney tissues in rats.
- MakaleAçık Erişim2025Mathematical analysis of fractional order Covid 19 epidemic model
Açikgöz, Pınar; Merdan, Mehmet
This article aims to examine the dynamics of the fractional epidemic model of covid 19. The model in question incorporates the notion of a compatible derivative. Given their consistent and worldwide characteristics, fractional derivatives are presently employed to address nu-merous practical issues. In addition, we employ two numerical techniques, namely the con-formal differential transform and the variational iteration approach, to provide an approxi-mate solution for the given model. The research closes by providing an in-depth analysis and visually representing the numerical findings. Furthermore, it has been demonstrated that the solution obtained is convergent.
- MakaleAçık Erişim2025The psychological consequences of 6 February 2023 Kahramanmaraş earthquakes
Kiymis, Ibrahim; Fakioglu, Merve
The Kahramanmaraş earthquakes (2023) are the largest and most destructive earthquakes witnessed in the era of the Republic of Turkey. Earthquakes lead to serious mental health disorders (MHD) such as Post-Traumatic Stress Disorder (PTSD) in individuals. Earthquakes that cause significant death and injury on a large scale, such as the Kahramanmaraş earthquakes, can result in various mental health disorders. Therefore, the aim of the study was to examine the effects of variables such as PTSD, event impact, psychological resilience, depression, and anxiety levels on adult earthquake survivors affected by the Kahramanmaraş earthquakes, using a quantitative research approach with survey techniques. A total of 662 earthquake survivors were reached. The effect of variables on each other was analyzed using Structural Equation Modeling (SEM). According to the findings of the study, event impact had a significant and positive effect on PTSD (β = 0.780, p = 0.000). Unexpectedly, resilience did not have a significant effect on PTSD (β=-0.04, p > 0.05). PTSD had a significant and positive effect on anxiety (β = 0.936, p = 0.000) and depression (β = 0.643, p = 0.000). Consequently, event impact’s severity increased PTSD, which in turn led to anxiety and depression. Surprisingly, psychological resilience did not serve as a protective factor against PTSD. For future research, it is recommended to examine psychological resilience with different event types, on different sample groups, and using more comprehensive and varied methods.
- MakaleAçık Erişim2025The effect of using a local skin cooling device on arteriovenous fistula cannulation pain and comfort level of patients on hemodialysis: A single-blind randomized controlled study
Demırağ, Hatice; Kulakaç, Nurşen
Introduction: The study aimed to investigate the impact of the using local skin cooling on arteriovenous fistula cannulation pain and the comfort levels of hemodialysis patients. Methods: The single-blind randomized controlled trial was formed with 50 patients between June 20, 2023, and July 31, 2023, in the hemodialysis units of two state hospitals in Turkey. Patients were randomly assigned to either the experimental group (n = 25) or the control group (n = 25) using the block randomization method. This data were collected through the use of the CoolSense device, the “Patient Information Form,” the “Verbal Category Scale,” and the “General Comfort Scale.” Patients in the experimental group received the local skin cooling for five seconds during arteriovenous fistula cannulation, while the control group followed the standard hospital protocol. The study was registered on Clinical Trials (NCT06144801). Findings: The study revealed that the application of the local skin cooling during arteriovenous fistula cannulation significantly reduced pain and increased patients’ comfort levels, demonstrating an anesthetic effect (p < 0.001). Furthermore, it was observed that as pain levels decreased, patient comfort levels increased (p < 0.001). Discussion: It is concluded that the using lokal skin cooling is an effective tool for reducing pain and enhancing comfort during arteriovenous fistula cannulation in hemodialysis patients.
- MakaleAçık Erişim2025The Effect of Audio-Visual Methods on Preoperative Anxiety in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Kulakaç, Nurşen; Ustuner Top, Fadime
Background: Children presenting to hospitals during the preoperative period are often exposed to procedures that cause significant stress. Through preoperative interventions, nurses play an important role in relieving the anxiety of children and their parents. Objective: This study was conducted to determine the effect of audio-visual methods on preoperative anxiety levels in children. Methods: PubMed (including MEDLINE), Cochrane, EBSCOHost, Web of Science, YÖK National Thesis Center, and Google Scholar databases of randomized controlled studies published in the last 10 years were searched for this meta-analysis. 32 studies were included in the meta-analysis, and the total sample size was 2795. Results: Q According to the results of the meta-analysis using the random-effects model, audio-visual methods had a positive effect on reducing anxiety (SMD: -1.312, %95 CI -1,666-(0,958), Z=-7,260, p < 0,001, Q-value = 556,572 I2 = 94.519). The moderator analysis demonstrated that cartoons (SMD:-1.645, p < 0.001), games (SMD:-1.931, p = 0.001), music (SMD:-0.534, p < 0.001), video showings (SMD:-1.363, p = 0.001), and virtual reality (SMD:-1.782, p < 0.001) reduced preoperative anxiety in children. Conclusions: Audio-visual methods are effective in reducing preoperative anxiety in children. The results of this study may provide pediatric perioperative nurses with additional information to help them decrease anxiety for patients and their families.
- MakaleAçık Erişim2025Effect of eHealth Interventions on Medication Adherence in Kidney Transplant Recipients: Meta-Analysis of Randomised Controlled Trials
Tuncer, Metin; Tuncer, Gülsüm Zekiye
Background: Kidney transplant recipients must take immunosuppressive drugs for life, and medication non-adherence is a primary risk factor for graft loss and death. With the advancement of technology, electronic health applications are widely used in chronic disease management and offer the potential to improve medication adherence in kidney transplant recipients. Aim: This meta-analysis aims to evaluate randomised controlled trials (RCTs) that assess the effectiveness of eHealth interventions in improving medication adherence among kidney transplant recipients. Methods: This study, which was designed as a systematic review and meta-analysis, followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocols in the planning and reporting phases. Electronic databases and manual literature searches were the two main data sources. Full-text RCTs in PubMed, Medline, Web of Science and Scopus databases were systematically searched. The searches covered studies from 2014 to March 2024. Results: The search yielded 524 articles. Eight RCTs with 779 participants were included in the analysis. The meta-analysis results indicated that, compared with the control group, adherence rates (RR: 1.19; 95% CI: 1.06–1.35; p = 0.01. Heterogeneity: Q = 8.69; p = 0.28; I2 = 19%) and adherence scores (SMD: 0.17; 95% CI: 0.05–0.29; p = 0.02. Heterogeneity: Q = 0.45; p = 0.93; I2 = 0%) significantly increased in the eHealth intervention group compared with the control group. Conclusion: The findings of this report show that eHealth interventions to improve medication adherence in kidney transplant recipients show favourable outcomes compared with standard care. We recommend eHealth interventions to improve long-term survival and patient outcomes in kidney transplant recipients.
- MakaleAçık Erişim2025Advanced brain tumor analysis: a novel strategy for segmentation and classification using modern computational methods
Reis, Hatice Catal; Turk, Veysel
Despite their low incidence, brain tumors are one of the most invasive cancer types, constituting a significant burden of death and disease in all age groups. Early and accurate diagnosis of brain tumors plays a vital role in reducing mortality rates. The heterogeneous nature of brain tumors and the diversity of tumor lesions may make it difficult for radiologists to make the right decision in the manual diagnosis process. This study proposes the use of machine learning methods for the classification of brain tumors (pituitary, meningioma, and glioma) and the use of metaheuristic algorithms graph theory, and random walker algorithms in the segmentation of brain tumors. The classification performed with the proposed method obtained an overall accuracy rate of 98.33%. In addition, the classification accuracy of 99.50%, 99.50%, 98.67%, and 99.00% was achieved for no tumor, pituitary, meningioma, and glioma, respectively. Experiments in the segmentation process show that metaheuristic algorithms and max-flow graph cut approach produce successful results.
- Kitap BölümüYalnız künye2025Assessment of Türkiye's Healthcare Quality Standards Using the FUCOM Method: FUCOM Method
Bolayir, Banu
This study aims to determine the importance ranking of healthcare quality standards in Türkiye. The latest version of the Healthcare Quality Standards-Hospital (Version 6.1) was used as the healthcare quality standards in Türkiye. The FUCOM method, one of the multi-criteria decision-making (MCDM) methods, was employed to rank the importance of these standards. To use this method, a questionnaire based on the healthcare quality standards was filled out by six experts. The data obtained from the questionnaire were transferred to Microsoft Excel Solver, and the FUCOM method was used with this program. Using the FUCOM method, the local importance weights of the main criteria and sub-criteria were initially determined. Then, the criteria were ranked based on these weights. Subsequently, after determining the global importance weights of the sub-criteria considering the local importance weights of both the main criteria and sub-criteria, their rankings were also established based on these weights.
- MakaleAçık Erişim2025Perioperative stress experiences of patients before surgical operation: A phenomenological study
ÖZKAN, Esra; BAYRAK, Nurten Gülsüm; UZUN, Sevda
Aim: The aim of this study was to evaluate patients' experiences of perioperative stress before surgery using a phenomenological approach. Design: In the study, in which phenomenological research method was used, semi- structured in-depth interviews were conducted with 12 patients who were treated in the orthopedics clinic. Method: Criterion sampling method, one of the purposive sampling methods, was used to reach the sample group. Interviews continued until data saturation was achieved. All interviews were recorded on a voice recorder after obtaining the necessary permissions and then transcribed. The data of the study were evaluated using thematic analysis. The study was conducted and reported according to the COREQ checklist. Results: In the analysis of the data, three main themes (situations experienced before the surgical operation, feelings and thoughts about the operating room, and perioperative stress and thoughts about healthcare professionals) and seven sub-themes (mental, physical, social, emotions, thoughts, positive thoughts and negative thoughts) were identified. Conclusion: It was found that patients experienced many psychosocial difficulties, especially fear and anxiety, in the preoperative period. It can be said that the difficulties experienced are related to both the surgical process and the operating room environment and the communication and interaction of healthcare professionals. In this context, determining the fear and anxiety levels of patients in the preoperative process, providing standardized comprehensive trainings to patients in order to prevent different practices related to the surgical process, organizing in-service trainings to strengthen the communication skills of healthcare professionals are very important for the healthy management of the process and providing holistic nursing care.
- MakaleAçık Erişim2025The effect of psychotherapeutic interventions on pain and quality of life in endometriosis: a systematic review and meta-analysis study
Özcan, Handan; Çuvadar, Ayşe; Uzun, Sevda
Aim: This study aimed to determine the effect of psychotherapeutic interventions on pain, quality of life and health profile in women diagnosed with endometriosis. Methods: For this systematic review and meta-analysis study, studies were obtained by searching PubMed, Web of Science, EBSCOhost, Google Scholar, and YÖK Thesis Center databases between August and October 2024 without any year limitation. After the review, 10 studies were included in the study. The data were synthesized by meta-analysis and narrative methods. Results: In this systematic review and meta-analysis, psychotherapeutic interventions for the treatment and management of endometriosis were found to be effective on quality of life (SMD = 0.515, 95% CI = 0.035 to 0.995; Z = 2.104, I2 = 67.523%, p < 0.05), pain (SMD = − 0.454, 95% CI = − 1.600 to − 0.179; Z = − 1.566, I2 = 84.463, p > 0.05), and health profile (SMD = 0.041, 95% CI = − 0.363 to 0.281; Z = − 0.250759, I2 = 56.876%, p > 0.05). In subgroup analyses, it was determined that the types of psychotherapeutic interventions were not effective, but the number of sessions was effective. Conclusion: Psychotherapeutic interventions to reduce symptoms in endometriosis are effective in improving quality of life but not pain and health profile.
- MakaleAçık Erişim2025The effect of omega-3 fatty acid use on women’s mental health in postpartum depression: a systematic review and meta-analysis study
Karakaş, Sevda; Uzun, Sevda; Özcan, Handan
- Derleme MakaleAçık Erişim2025The Effect of storybook use in pediatric health services on children's fear and anxiety levels: A meta-analysis study
Akay, Gamze; Uzun, Sevda; Oğuzhan, Hatice; Güdücü Tüfekci, Fatma
Background: Invasive procedures are commonly used in pediatric healthcare, and storybooks can be used as an adjunct analgesic method. Objectives: This study was conducted to evaluate the effectiveness of using storybooks as a distraction technique to reduce fear and anxiety in pediatric healthcare. This study was conducted with the aim of revealing the level of effect of storybook use on children's fear and anxiety level in pediatric health services. Methods: For this meta-analysis study, the studies were obtained by searching PubMed, Web of Scıence, Scopus, EBSCOhost, Google Scholar and YÖK Thesis Center databases in April–June 2024 without any year limitation. After the reviews, 15 studies were included in the study. The data were synthesized by meta-analysis and narrative methods. Findings: In this meta-analysis, it was found that storybook use in pediatric health services was effective on children's anxiety (SMD: −4.412, 95 % CI: −7.727 to −1.097; Z = −2.608, p = 0.009; I2 = 99.890 %) and fear (SMD: −1.13, 95 % CI: −1.71 to −0.54; Z = −3.78, p = 0.000; I2 = 83.065 %) levels. In addition, it was determined that the characteristics of the intervention group, age group, the characteristics and content of the storybook, the duration of the intervention and the time of the intervention played a role in the effectiveness of the storybook use intervention in pediatric health services on children's anxiety and fear levels. Conclusion: The use of story books in children's health services reduces the level of fear and anxiety in children.
- MakaleAçık Erişim2025Brain Drain-Related Perspectives of Senior Nursing Students in Türkiye: A Qualitative Study; [Türkiye'deki Son Sınıf Hemşirelik Öğrencilerinin Beyin Göçüyle İlgili Görüşleri: Nitel Bir Çalışma]
Tuncer, Metin; Tuncer, Gülsüm Zekiye
Objective: This study was aimed at investigating the brain drain-related perspectives of nursing students who wanted to emigrate in depth. Methods: The study has the descriptive qualitative research design. The population of the study comprised 13 senior nursing students studying at the Faculty of Nursing of a university and intending to emigrate abroad. Data were collected through face-to-face individual in-depth interviews. The interviews were audio-recorded after the participants’ permission was obtained. This study adopted a qualitative research design based on inductive content analysis to explore the participants’ perspectives in depth. Results: In this study, three themes emerged from the students' opinions: "Perception of brain drain", "Motivation behind brain drain" and "Challenges". The first theme reflected students’ varied views on migration, including both positive and negative perceptions, a growing social trend towards emigration, and feelings of hopelessness and dissatisfaction with nursing in Türkiye, leading to the formation of personal migration plans. The second theme captured motivations such as the influence of relatives and role models abroad, favourable personal conditions, attractive opportunities overseas, language efforts, and openness to new experiences. The final theme focused on challenges, including push factors like poor working conditions and low wages, barriers such as language and time constraints, and emotional concerns such as loneliness and cultural adjustment. Conclusion: The study showed that nursing students’ intention to emigrate stems from mixed perceptions of brain drain, strong personal and social motivations, and various emotional and structural challenges. Addressing these issues may help mitigate future nurse migration.
- MakaleAçık Erişim2025Effect of Foot Anthropometric Measurements on Pain and Functional Disability of Pregnant and Nonpregnant Women
Koca, Rabia; Sen, Müserref Ebru; Yılmazer, Mehmet
Background: Weight gain during pregnancy, loosening of the foot ligaments with relaxin hormone release, and anthropometric and biomechanical changes can be seen in the foot with the growing fetus. We sought to determine whether these pregnancy-related changes cause painful musculoskeletal problems by altering the proximal structures of the lower extremities and the structure of the spine. Methods: Both feet of 210 women (half in the third trimester of pregnancy) aged 18 to 40 years with similar demographic characteristics were evaluated by measuring navicular drop, hallux valgus angle, foot width, foot length, and tibiocalcaneal angle. Foot Function Index for foot-ankle, Kujala Patellofemoral Score for knee, Western Ontario and McMaster Universities Osteoarthritis Index for hip, Oswestry Disability Index for waist, and Modified Neck Disability Index for neck were used to determine pain and functional limitation. Results: Pain and functional disability in the waist, hip, knee, and foot-ankle joints; navicular drop; hallux valgus angle; and tibiocalcaneal angle were significantly higher in pregnant women versus the control group (P < .001). Pain and dysfunction in all of the joints increased as navicular drop increased in pregnant and nonpregnant women. In addition, the increase in other anthropometric measurements in both groups was determined to caused pain and functional disability in most of the women, especially in foot-ankle joints. However, the cause of joint pain and functional deficiencies was unrelated to pregnancy. Conclusions: Foot deformities and proximal region complaints were significantly higher in pregnant women, and foot deformities caused more foot-ankle pain and disability in both groups. No difference was observed in pregnant women versus the control group.
- MakaleAçık Erişim2025Development and Validation of a Scale Based on Protection Motivation Theory to Investigate Factors Affecting Earthquake Preparedness Behaviors
Yücel, Hasan; Cengiz, Sevil
Given Türkiye’s high seismic risk, earthquake preparedness is vital. This study explored factors affecting earthquake preparedness behaviors among residents in high-risk areas. The factors affecting earthquake preparedness behaviors Scale based on protection motivation theory was developed, and its validity was tested. Scale development consists of a pilot and main application process. The pilot application was carried out with 50 participants, and the main application was carried out with 804 participants. The sample consisted of 804 participants who were divided into two groups for exploratory and confirmatory factor analysis. The sample was selected from 11 neighborhoods using the cluster sampling method. IBM SPSS 25 was used for exploratory factor analysis, while AMOS 24.0 was employed for confirmatory factor analysis. The final version of the scale consists of 24 items across four dimensions, with a Cronbach’s alpha of 0.883, exceeding the acceptable threshold of 0.7 for each dimension. The Kaiser–Meyer–Olkin value is 0.898, and Bartlett’s test of sphericity is significant, with the total variance explained being 51%. Confirmatory factor analysis results indicate a good fit for both the measurement and structural models (χ2/df = 1.779; RMSEA = 0.44; CFI = 0.96; NFI = 0.91; TLI = 0.95; p<0.001). Structural equation modeling showed that, among the constructs of protection motivation theory, perceived efficacy (β = 0.690) is the most important factor affecting earthquake preparedness behaviors. The results show that the scale is a valid and reliable tool to determine the factors affecting earthquake preparedness behaviors in Turkish society.
- MakaleAçık Erişim2025Response of tibia bone morphology, biomechanics and minerals to Organic Hawthorn (Crataegus tanacetifolia) Fruit Vinegar application in broiler chickens exposed to cyclic heat stress
Kaya, Hacer
This study aimed to determine the effects of adding different doses of organic hawthorn fruit vinegar (HFV) to the drinking water of male broilers (Ross 308) reared under cyclic heat stress (CHS) on tibia bone morphology, biomechanics, and minerals. Broilers were distributed into six groups based on a 2 × 3 factorial design, testing two ambient temperatures (24 and 35°C CHS for 8 h/day starting from day 21) and three HFV levels (0, 2, and 4 ml/L). Cyclic heat stress had no effect on the morphological and biomechanical properties of the tibia bone, except for a decrease in cortex thickness (P < 0.05). However, CHS significantly decreased the bone Ca, P, Mg, Cu, Zn, Mn, and K levels, while increasing the Fe levels (P < 0.01). The addition of 2 and 4 ml/L HFV had no effect on the morphological and biomechanical properties of the tibia bone (P > 0.05), except for an increase in bone diameter with 2 ml/L HFV (P < 0.05). HFV additions were not sufficient to increase the Ca level decreased by CHS, and the tibia bone Ca level of birds under CHS decreased further with HFV additions (P < 0.01). Conversely, 2 ml/L HFV increased Mg levels, and both 2 and 4 ml/L HFV increased Cu, Fe, Zn, and Mn levels, whereas P levels decreased (P < 0.01). K level decreased with 2 ml/L HFV and increased with 4 ml/L HFV supplementation. In conclusion, HFV supplementation has positive effects on bone mineralization in broilers exposed to HS and can be used up to 4 ml/L to mitigate the negative effects of heat stress.
- EditoryalAçık Erişim2025Technological Products in Cancer Care: Challenges for Nurses and Patients
Aydin, Aydanur
- MakaleAçık Erişim2025The Effect of Boric Acid on Oxidative Stress, Inflammation, and Apoptosis in Embryonic and Fetal Tissues Damage Caused by Consumption of High-Fructose Corn Syrup in Pregnant Rats
Başeğmez, Mehmet; Yüksel, Duygu
This study aimed to determine the protective role of boric acid in a pregnant rat model of high fructose corn syrup consumption. Consumption of high fructose corn syrup has been associated with adverse health outcomes in humans and animals. Twenty-eight healthy female Wistar albino rats (250–300 g weight and 16–24 weeks old) were randomly distributed into four equal groups (n = 7): Control, Boric acid (BA), High Fructose Corn Syrup (HFCS), HFCS + BA. Boric acid (20 mg/kg) was administered to pregnant rats via oral gavage every day during pregnancy. The prepared 30% HFCS (F30) solution (24% fructose, 28% dextrose) was added to the drinking water throughout pregnancy. At the end of pregnancy (day 19), blood, placenta, uterus, and fetuses were collected from rats. The results indicated that HFCS increases oxidative stress by increasing the level of MDA and decreasing GSH, SOD, and CAT activity in the blood of maternal. However, BA administration significantly decreased MDA levels and increased GSH levels, SOD, and CAT activity (p < 0.05). In addition, HFCS consumption significantly increased plasma TNF-α, IL-6, and leptin levels compared to control, BA, and HFCS + BA groups (p < 0.05). However, BA administration significantly decreased plasma TNF-α, IL-6, and leptin levels (p < 0.05). Furthermore, BA (20 mg/kg) significantly decreased HFCS-induced histopathological and immunohistochemical alterations in the placenta, uterus, and fetal tissue. In conclusion, BA may prevent HFCS toxicity in maternal and fetal tissues, as it regulates oxidative imbalance in pregnant rat and alleviates histopathological and immunohistochemical changes. The findings indicate a need for further studies to assess the potential of boron in preventing or mitigating the effects of HFCS during pregnancy.
