Sürdürülebilir Kalkınma Amaçları
Yayınlar
- EditoryalYalnız künye2025Choroidal melanoma missed on brain MRI: Small lesion, big consequences
Tonkaz, Gokhan; Akdeniz, Cemre; Tonkaz, Mehmet; Tonkaz, Duygu Erkal
- EditoryalYalnız künye2024A rare form of enterovesical fistula: Appendicovesical fistula
Tonkaz, Duygu Erkal; Tonkaz, Mehmet
- EditoryalYalnız künye2024An uncommon cause of macrodactyly: Lipomatous macrodystrophy
Tonkaz, Duygu Erkal; Tonkaz, Mehmet
- EditoryalYalnız künye2024Xanthogranulomatous pyelonephritis: Bear's paw sign
Tonkaz, Gokhan; Tonkaz, Mehmet; Tonkaz, Duygu Erkal; Ay, Mutlu; Pirimoglu, Rustem Berhan
- EditoryalYalnız künye2024A rare cause of acute abdominal pain: Perforation of a hepatic hydatid cyst into the peritoneum
Tonkaz, Gokhan; Akdeniz, Cemre; Tonkaz, Mehmet; Tonkaz, Duygu Erkal; Aslan, Serdar
- EditoryalYalnız künye2024A rare case of intraosseous calcaneal lipoma with calcific and cystic components
Tonkaz, Gokhan; Akdeniz, Cemre; Tonkaz, Mehmet; Tonkaz, Duygu Erkal; Bekci, Tumay
- EditoryalAçık Erişim2024A rare case: cerebral air embolism causing stroke after lung cancer ablation
Tonkaz, Mehmet; Tonkaz, Duygu Erkal; Tonkaz, Gokhan
- MakaleYalnız künye2024Efficacy of fat quantification methods used in MRI to distinguish between normal, benign, and malignant bone marrow pathologies in children
Tonkaz, Duygu Erkal; Ozpar, Rifat; Tonkaz, Mehmet; Yazici, Zeynep
Background Fat quantification methods in magnetic resonance imaging (MRI) have been studied to differentiate bone marrow pathologies in adult patients; however, scarce literature is available in pediatric patients.Purpose To evaluate the efficacy of the T1 signal intensity value (T1-SIV), out-of-phase/in-phase signal ratio (OP/IP SR), and fat fraction (FF) to differentiate between normal, benign, and malignant pathological processes.Material and Methods A total of 48 pediatric patients with lumbar and pelvic MRI were classified into three groups according to bone marrow pathology (group 1, normal; group 2, benign pathology/reconversion; group 3, malignant). The efficacy of T1-SIV, OP/IP SR, and FF values in differentiating these pathologies was evaluated using Kruskal-Wallis or analysis of variance and followed by Bonferroni or Dunn-Bonferroni tests. Cutoff values for malignant infiltration were defined using ROC analysis.Results Although these values were significantly different in all three groups (P = 0.001-0.008), this difference was not sufficient to discriminate between all groups. Subgroup analyses showed significant differences in T1-SIV between groups 1-3, in OP/IP SR between groups 1-3, 2-3, and 1-2, in FF between groups 1-2 and 1-3 in various regions (P = 0.001-0.049). Cutoff values had a sensitivity and specificity of 90%-100% for OP/IP SR and FF.Conclusion T1-SIV, OP/IP SR, and FF may potentially distinguish normal from pathological bone marrow. OP/IP SR and FF values detected malignant infiltration with high sensitivity and specificity in this study. However, only OP/IP SR may significantly differentiate benign and malignant bone marrow pathologies which needs to be confirmed in the future study with a larger patient population.
- EditoryalYalnız künye2024A rare lesion of the clivus: Neuroenteric cyst
Tonkaz, Gokhankhan; Kaya, Abdulkadir; Tonkaz, Mehmet; Tonkaz, Duygu Erkal
- MakaleYalnız künye2024Efficacy of transarterial chemoembolization treatment with 30-60-μm microspheres in patients with hepatocellular carcinoma
Tonkaz, Mehmet; Nas, Omer Fatih; Erkal Tonkaz, Duygu; Inecikli, Mehmet Fatih; Ongen, Gokhan; Ozkaya, Guven
Background: Chemoembolization with small drug-eluting microspheres is widely used in the treatment of hepatocellular carcinoma (HCC). Objectives: This study aimed to evaluate the efficacy and safety of transarterial chemoembolization with doxorubicin-eluting 30-60-mu m microspheres (DEB-TACE) in patients with Barcelona Clinic Liver Cancer (BCLC) stage A and B HCC. Materials and methods: In this single-center study, 88 patients with HCC (BCLC A/B: 15.9%/84.1%) who underwent 137 DEB-TACE sessions between January 2015 and December 2020 were retrospectively assessed. Response to treatment was assessed 4-8 weeks after each DEB-TACE procedure according to mRECIST (Modified Response Evaluation Criteria in Solid Tumors) criteria. Progression-free survival (PFS), time to progression (TTP), overall survival (OS), and adverse events were recorded. Results: In 88 patients (84.1% males; median age, 66.0 years; range, 22-83), the median follow-up was 17 months (range, 2-64). Eight patients (9.1%) had a complete response, 42 (47.8%) had partial regression, 10 (11.3%) had stable disease, and 28 (31.8%) had progressive disease. There was a statistically significant difference between serum alpha-fetoprotein (AFP) levels before and after DEB-TACE treatment (p < 0.001). The median OS was 17 months (95% confidence interval [CI], 10.3-23.7). Cox regression analyses found that preprocedural serum AFP level (400+ vs. < 400; p = 0.024), Child Pugh classification (B vs. A; p = 0.019), and number of DEB-TACE sessions (1 vs. > 1; p = 0.003) were independent risk factors affecting OS. The median PFS was 8 months (95% CI, 5.8-10.2) and TTP was 6 months (1-14 months). Conclusion: Chemoembolization with 30-60-mu m microspheres is an effective and safe treatment for HCC. The number of DEB-TACE sessions is also one of the factors affecting OS.
- EditoryalYalnız künye2023Paraspinal cervical chordoma
Tonkaz, Gokhan; Yitik, Ahmet Yasin; Tonkaz, Mehmet; Tonkaz, Duygu Erkal; Sade, Recep
- MakaleAçık Erişim2023A needful, unique, and in-place evaluation of the injuries in earthquake victims with computed tomography, in catastrophic disasters! The 2023 Turkey-Syria earthquakes: part I
Cakir, Ismet Mirac; Sengul, Ilker; Bekci, Tumay; Tonkaz, Gokhan; Eryuruk, Uluhan; Onder, Ramazan Orkun; Aksoy, Iskender; Bayar, Ayse Elif; Tonkaz, Mehmet; Sengul, Demet
OBJECTIVE: This study was carried out to evaluate the injuries in pediatric earthquake victims due to the 2023 Turkey-Syria earthquakes with computed tomography and determine the anatomotopographic distribution of injuries. METHODS: The material of this retrospective study consisted of the computed tomography findings of 257 pediatric cases injured in the 2023 Turkey-Syria earthquakes, and those were divided into subgroups based on their age group, i.e., 0-4, 5-9, 10-14, and 15-18 years, and the type of injury, i.e., head, maxillofacial, thoracic, abdominal, pelvic, and spinal injuries. RESULTS: Earthquake-related injuries had been detected in 102 (39.6%) patients. Of the 29 patients with multiple injuries, 17, 10, and 2 had injuries in two, three, and four topographic regions, respectively. The most common injury was a head injury, which was detected in 48 (18.7%) cases, followed by thoracic injury, spinal injury, pelvic fracture, abdominal injury, and maxillofacial fracture, which were detected in 40 (15.6%), 22 (8.5%), 19 (7.4%), 10 (3.9%), and 6 (2.3%) patients, respectively. The cranial bone fractures and intracranial injuries were significantly more frequent in the 0-4 years age group compared with other age groups (p=0.028 and p=0.024, respectively). The rib fractures with spinal and pleural injuries were significantly more common in the 15-18 years age group compared with others (p=0.016, p=0.004, and p=0.002, respectively). CONCLUSION: The head injury was the most common earthquake-related injury in pediatric cases. Herein, it was more common in younger children compared with other age groups, whereas rib, spine, and pleural injuries were more common in older children.