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Araştırmacılar(146)

• Acet, Tuba
• Agac, Gokhan
• Akar, Zeynep
• Akbal, Alev
• Akdemir, Rabia Rümeysa
• Akıl, Fatoş
• Aksoy, Bahar
• Aktaş, Esra
• Aktaş, Songül
• Aktuğ, Cemile
• Akyıldız, Esma
• Akyol, Hikmet
• Altın, Gökhan
• Altindaş, Sueda
• Apaydin Cirik, Vildan
• Arpa Zemzemoglu, Tuba Eda
• Arpa, Tuba Eda
• Aslan, Çimen
• Aslan, Ramazan
• Ay, Özge Palancı
• Ayan, Mahsun
• Aydın, Aydanur
• Aydın, Esra
• Aydın, Rüveyde
• Aydin, Arzu
• Aygül, İmdat
• Ayker, Bereket
• Aykut, Memnune Kabakuş
• Aysu, Şühedanur
• Ayvaz, Hilal
• Bahar, Rabia
• Balaban Yücesan, Fulya
• Barlak, Yaşam
• Bas, Cağla Firdevs
• Baskin, Sema
• Baygin, Şevval
• Bayram, Hakan
• Bekar, Fevziye
• Bodur, Ali Fuat
• Bor, Hakan
• Bostan, Sedat
• Burnaz, Nesibe Arslan
• Büyükçerçi, Nilda Nur
• Canik, Muhammed
• Cengiz, Sevil
• Coşkun, Gülizar
• Dere, Cansu
• Dinç, Artum
• Dogan, Ahsen Aydin
• Doğan, Melike Demir
• Doğanay, Fatma
• Duman, Münevver
• Düzgün, Azer Özad
• Efe, Ömer Faruk
• Eker, H.H.
• Ekti, Hatun
• Elik, Burak
• Fakıoğlu, Merve
• Geliç, Büşra
• Gökcan, Ahmet

• MakaleYalnız künye2027/r/gumushane/13661
  Serial mediating role of belonging and state mindfulness in the relationship between clinical learning environment and caring behaviors in nursing students

  Özalp, Cemal; Tuncer, Metin; Kaya, Abdulsamed; Şahin, Fatih

  Aim: The study aimed to examine the relationship between clinical learning environment and caring behaviors in nursing students and to test the serial mediating roles of belonging and state mindfulness in this relationship. Background: The psychosocial mechanisms linking the clinical learning environment to caring behaviors remain unclear, particularly the combined roles of belonging and state mindfulness. Design: The study had a cross-sectional design and was conducted in line with the STROBE guidelines. Methods: The sample consisted of 452 undergraduate nursing students studying at a state university in Turkiye. The data were collected between December 2025 and January 2026 using the Personal Information Form, Clinical Learning Environment Scale, Nursing Department Belonging Scale, State Mindfulness Scale, and Caring Behaviors Inventory. Results: The clinical learning environment was found to be positively correlated with sense of belonging (B = 0.412, p < .001). Sense of belonging significantly predicted both State Mindfulness (B = 0.607, p < .001) and caring behaviors (B = 0.857, p < .001). State mindfulness is also a significant predictor of caring behaviors (B = 0.734, p < .001). Indirect effects analyses indicated that the clinical learning environment was associated with caring behaviors through sense of belonging and through the sequential pathway involving both sense of belonging and state mindfulness. However, the direct effect of the clinical learning environment on caring behaviors was not significant. Additionally, the indirect effect of the clinical learning environment on caring behaviors through state mindfulness alone was not significant. Conclusions: The results of the study showed that the clinical learning environment is associated with nursing students' caring behaviors indirectly through sense of belonging and state mindfulness, rather than directly.

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• MakaleAçık Erişim2027/r/gumushane/13496
  Development of flood fear scale and investigation of psychometric properties

  Torpuş, Kemal; Cengiz, Sevil

  This study aimed to develop a flood fear scale. The study was designed as a methodological and cross-sectional study. The study was conducted with 1158 participants aged 18–65 residing in Türkiye’s Black Sea Region between February 15, 2025, and May 15, 2025. SPSS 25 and Amos 21 programs were used to analyze the data. The flood fear scale consists of four dimensions and 26 items. The Cronbach’s alpha coefficient was 0.948, and the scale explained 62.644% of the total variance. The model fit indices were χ2/ df = 3.444, RMSEA = 0.065, SRMR = 0.056, CFI = 0.921, IFI = 0.922, NFI = 0.893, and TLI = 0.912. The findings indicated that the flood fear scale provided valid and reliable for adults aged 18–65 residing in Türkiye’s Black Sea Region. The total scores obtainable from the scale range from 26 to 130, with higher scores indicating an increased level of flood fear. Scale can be used to assess flood fear in community-based disaster risk reduction efforts. It is recommended that validity and reliability studies of the scale be conducted in different cultures and geographical regions.

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• MakaleAçık Erişim2027/r/gumushane/13442
  Design, Synthesis, and X-ray Characterization of Benzohydrazide Derivatives as Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: An Experimental and Computational Approach to Biological Activity

  Topal, Fevzi; Ünver, Hakan; Topal, Meryem; Çevik, Ulviye Acar; Kırboğa, Kevser Kübra; Işık, Mesut; Beydemir, Şükrü

  In this study, a series of new benzohydrazide derivatives (1a-i) were synthesized, and characterized as potential cholinesterase inhibitors for use in the treatment of Alzheimer’s disease (AD). The inhibitory activities of the synthesized compounds against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were evaluated using in vitro and in silico methods. IC50 values for AChE inhibition ranged from 29.50 to 46.21 nM, with compound 1c exhibiting the highest inhibitory potential at an IC50 of 29.50 nM. For the BChE enzyme, the strongest effect was observed with compound 1d at an IC50 of 55 nM. The synthesized derivatives exhibited higher inhibitory potential compared to the reference tacrine (IC50: 58.73 nM for AChE and 187.30 nM for BChE) against cholinesterase enzymes through both competitive and non-competitive inhibition mechanisms. Molecular docking (ΔG: -10.67 to -9.95 kcal/mol for AChE; -9.80 to -8.69 kcal/mol for BChE) and 100 ns molecular dynamics simulations supported the binding affinities and indicated the dynamic stability of the enzyme-inhibitor complexes, in agreement with the experimental inhibition data. In silico ADMET profiling indicated favourable drug-likeness and high predicted gastrointestinal absorption and blood-brain barrier permeability (TPSA 41.46-61.69 A2), and structural alert screening returned no PAINS matches. The findings suggest that these derivatives may serve as promising lead compounds for further investigation as potential cholinesterase inhibitors relevant to AD, pending experimental cytotoxicity evaluation.

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• MakaleAçık Erişim2026/r/gumushane/10625
  Mono- and Bis-Ureido Sulfapyridines as Nanomolar Dual Cholinesterase Inhibitors: Enzyme Kinetics, Molecular Docking, and ADME/Tox Insights

  Yapar, Gonul; Akocak, Suleyman; Lolak, Nebih; Topal, Meryem; Türkes, Cuneyt; Topal, Fevzi; Durgun, Mustafa; Koçyigit, Umit Muhammet; Isik, Mesut; Beydemir, Sukru

  A series of mono- and bis-ureido sulfapyridine derivatives (SP-1-SP-10) were synthesized and evaluated as dual cholinesterase inhibitors targeting acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). All compounds exhibited nanomolar inhibition. The most potent AChE inhibitors were SP-8 (K-i = 5.25 +/- 0.73 nM), SP-9 (5.09 +/- 0.44 nM), and SP-10 (5.74 +/- 0.55 nM), significantly outperforming tacrine (K-i = 105.03 +/- 8.85 nM) under identical conditions. For BChE, SP-9 showed the strongest inhibition (K-i = 26.38 +/- 2.07 nM) compared with tacrine (172.03 +/- 32.42 nM). Kinetic analyses revealed competitive inhibition toward AChE for all derivatives, whereas BChE inhibition displayed both competitive and noncompetitive patterns depending on structural features. Glide XP docking using AChE (PDB: 7XN1) and BChE (PDB: 4BDS), complemented by MM-GBSA binding free energy calculations, supported favorable ligand accommodation within the catalytic pockets and highlighted the importance of aromatic and hydrophobic interactions. In silico ADME/Tox analysis revealed a potency-drug-likeness trade-off: mono-ureido derivatives complied with Lipinski's rule of five and showed high predicted oral absorption, whereas bis-ureido derivatives, despite superior enzymatic potency, exhibited multiple drug-likeness violations. These findings identify the ureido-sulfapyridine scaffold as a potent enzymatic dual cholinesterase inhibitory framework, warranting further structural optimization to improve pharmacokinetic properties.

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• MakaleAçık Erişim2026/r/gumushane/10552
  In Vitro Antioxidant, Antibacterial, and Cholinesterase-Inhibitory Properties of an AqueousEuphorbia macrocladaRoot Extract Obtained by Ultrasound-Assisted Extraction

  Gül, Abdulkadir; Yilmaz, Firat; Topal, Fevzi; Özgen, Inanc; Aydogmus, Ercan; Arslanoglu, Hasan

  In the present study, the aqueous extract obtained from the roots of Euphorbia macroclada via ultrasound-assisted extraction (Ult-ER) was evaluated for its anticholinesterase (AChE and BChE), antioxidant, and antibacterial activities. While the extract exhibited weak inhibition against AChE (IC50: 507.69 +/- 17.95 mg/mL), it showed relatively greater inhibitory activity against BChE (IC50: 22.41 +/- 0.49 mg/mL). In antioxidant assays, Ult-ER exhibited measurable antioxidant responses, with DPPH and ABTS(+) radical-scavenging capacities of 18.33 +/- 0.49 and 119.59 +/- 1.86 mg TE/L, respectively. Its Fe-3(+) and Cu-2(+) reducing capacities were 128.51 +/- 12.57 and 670.33 +/- 11.59 mg TE/L, respectively. The total phenolic and flavonoid contents were 84.80 +/- 3.31 mg GAE/g and 60.67 +/- 2.29 mg QE/g, while the total antioxidant capacity was 9.78 +/- 0.44 mg TE/g and 15.62 +/- 1.85 mg BHAE/g. In the antibacterial evaluation, Ult-ER at the highest tested concentration of 8 mg/mL exhibited inhibitory activity against all tested strains, including Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853, whereas no detectable inhibition was observed at lower concentrations.

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• MakaleAçık Erişim2026/r/gumushane/16266
  Determinants of healthy orthorexia and orthorexia nervosa: the roles of food security, dietary behaviors, and obesogenic environment

  Koçak, Tevfik; Arpa Zemzemoglu, Tuba Eda; Türkkan, Tugba; Bülbül, Kenan; Yilmaz, Birsen

  Orthorexia has recently gained attention as a two-dimensional construct centered on a shared health orientation. Recent conceptual developments distinguish healthy orthorexia (HeOr), defined as a non-pathological interest in healthy eating, from orthorexia nervosa (OrNe), characterized by rigid and compulsive food control accompanied by psychological and social impairment. This cross-sectional study investigated the associations of HeOr and OrNe with sociodemographic variables, dietary behaviors, and obesogenic environmental factors, and aimed to identify shared and distinct determinants of these tendencies with 1,015 adults aged 18-65 years. Orthorexia tendencies were assessed using the Teruel Orthorexia Scale. Additional measures included the Sustainable and Healthy Eating Behaviors Scale, Short Screening Questionnaire of Highly Processed Food Consumption, Adult Food Security Survey Module, Food Label Reading Attitude Scale, Food Choice Questionnaire, and the Obesogenic Environment Assessment Scale. In the adjusted regression models, HeOr was positively associated with sustainable and healthy eating behaviors (beta = 0.26), AFSS food-insecurity severity score (beta = 0.11), food label reading attitudes (beta = 0.07), health-related food choice motives (beta = 0.09), natural-ingredient preference (beta = 0.14), weight-control motives (beta = 0.15), ethical food choice motives (beta = 0.10), and obesogenic social determinants and effects (beta = 0.09). Conversely, affordability-related motives (beta = -0.08), emotional appeal (beta = -0.15), familiarity (beta = -0.10), and obesogenic cultural determinants/access to experts (beta = -0.12) were negatively associated with HeOr. For OrNe, positive associations were observed with sustainable and healthy eating behaviors (beta = 0.13), AFSS food-insecurity severity score (beta = 0.17), mood-related food choice motives (beta = 0.13), weight-control motives (beta = 0.26), familiarity (beta = 0.09), ethical food choice motives (beta = 0.18), and obesogenic social determinants and effects (beta = 0.30), whereas health-related food choice motives (beta = -0.12), affordability-related motives (beta = -0.08), and emotional appeal (beta = -0.24) showed negative associations. These findings suggest that orthorectic tendencies are associated with individual health motivations as well as broader behavioral and environmental contexts; however, because of the cross-sectional design, these associations should be interpreted as correlational and hypothesis-generating rather than causal.

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• MakaleYayıncıda açık erişim2026/r/gumushane/16102
  What is the Contribution of Green Innovation and Digitalization to Economic Growth: Analyzing the Role of Geopolitical Risks and

  Agirkaya, Melahat Batu; Akyol, Hikmet

  This research examines the impact of green innovation and digitalization on economic growth in Brazil, Russia, India, China, South Africa, and T & uuml;rkiye (BRICS+T) during the period 2002-2021. Within this framework, it analyzes the role of geopolitical risks and climate policy uncertainty. The relationships between variables were estimated using Pooled Bewley (CPS-BP), Dynamic Least Squares Mean Group (DOLS-MG), Fully Modified Least Squares (FMOLS), Canonical Cointegrated Regression (CCR), and Dynamic Least Squares (DOLS) estimators. Our results show that green innovation, digitalization, information technologies, infrastructure investments, life expectancy at birth, and US-originated climate policy uncertainties positively impacted economic growth. Increased geopolitical risks hindered growth in BRICS+T countries.

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• MakaleYalnız künye2026/r/gumushane/10587
  Comparison of automated subcortical segmentation methods: VolBrain vs. 3D Slicer in brain volumetry

  Acer, Niyazi; Palanci, Ozgur; Ipekten, Funda; Erdogan, Furkan Mert; Yarar, Burhan; Ozyasar, Ali Faruk

  Objective:Accurate volume measurements of subcortical brain structures are essential in neuroimaging studies. This study aimed to compare two automated segmentation algorithms, 3D Slicer and VolBrain, for subcortical brain volumetry. Method:Subcortical volume measurements obtained using 3D Slicer and VolBrain were compared using the Neurofeedback Skull-stripped (NFBS) dataset. Statistical analyses included the coefficient of determination (R2) and Bland-Altman (B-A) plots. Volumetric measurements from both tools were evaluated across multiple subcortical brain regions. Results:Strong agreement was observed for the caudate nucleus, thalamus, and hippocampus, while notable discrepancies were identified in the amygdala, globus pallidus, and nucleus accumbens. Both constant and proportional systematic errors were detected in certain regions, with greater variability observed in 3D Slicer measurements. Intraclass Correlation Coefficient (ICC) analysis demonstrated weak agreement for the accumbens and amygdala, and moderate agreement for the hippocampus and thalamus, highlighting region-specific differences in performance Conclusion:Both VolBrain and 3D Slicer are effective tools for subcortical brain volumetry. VolBrain provides a fully automated workflow, whereas 3D Slicer allows greater flexibility through detailed corrections. Method selection should be guided by research objectives, regions of interest, and image quality. Further validation across diverse datasets is warranted to improve clinical applicability, particularly in regions showing lower agreement.

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• MakaleYalnız künye2026/r/gumushane/10493
  Novel Approach to Synthesis of Diaryl Tacrine Derivatives and Evaluation of Their Inhibitory Effects on Cholinesterase Enzymes

  Topal, Fevzi; Ökten, Salih; Misir, Busra Albayrak; Koçyigit, Umit Muhammet; Derin, Yavuz; Atalay, Vildan Enisoglu; Tutar, Ahmet; Topal, Meryem

  The development of effective acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors remains a crucial objective in the treatment of neurodegenerative diseases, including Alzheimer's disease (AD). In this study, a novel synthetic approach was established to prepare a series of diaryl-substituted tacrine derivatives. Initially, brominated aminobenzonitrile was subjected to Suzuki-Miyaura cross-coupling reactions with various aryl boronic acids to yielding diaryl-substituted aminobenzonitriles at yields of 60%-72%. These intermediates were then cyclized with cyclohexanone and cycloheptanone under Friedl & auml;nder conditions using BF3 & centerdot;OEt2 as a catalyst, affording six- and seven-membered diaryl tacrine analogues in yields of 52%-68%. All synthesized compounds were characterized by NMR, IR, and elemental analysis. The inhibitory activities of these compounds (7-16) against AChE and BChE were evaluated, and several analogs demonstrated potent dual-enzyme inhibition at nanomolar concentrations. Notably, compounds 8 and 13 exhibited half maximal inhibitory concentration (IC50) values of 6.848 and 8.545 nmol/L for BChE, respectively, indicating strong potential as selective cholinesterase inhibitors. The structure-activity relationship (SAR) analysis revealed the influence of aryl substituents on the potency and selectivity of enzyme inhibition. Compared to previously reported tacrine derivatives, the newly synthesized analogs exhibited superior inhibitory profiles, indicating their potential as lead compounds for further development in AD therapeutics. [GRAPHICS] .

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• MakaleAçık Erişim2026/r/gumushane/10425
  Positive attitudes toward and perceived importance of wearable display technology as an effective learning tool among nursing students: Turkish validity and reliability study

  Aydin, Aydanur; Mese, Sevinc; Ay, Ali; Sezer, Hale; Rizalar, Selda; Güler, Sevil; Gürsoy, Ayla

  Objective This research aimed to adapt Positive Attitudes Toward and Perceived Importance of Wearable Display Technology (PATPIWDT) as an Effective Learning Tool Among Nursing Students into Turkish and to examine the validity and reliability of its translation.Methods This methodological study included 698 nursing students recruited via convenience sampling. Construct validity was evaluated using Confirmatory Factor Analysis (CFA) with the Maximum Likelihood (ML) estimation method. Internal consistency was assessed using Cronbach's Alpha and McDonald's Omega coefficients.Results The model demonstrated excellent fit according to the confirmatory factor analysis results. The CFA results for the Positive Attitudes subscale indicated a good model fit (CMIN/DF = 4.79, GFI = 0.93, CFI = 0.97, RMSEA = 0.07, SRMR = 0.03). For the Perceived Importance subscale, the single-factor structure showed acceptable fit indices (CMIN/DF = 5.82, GFI = 0.98, SRMR = 0.03). As a result of examining the standardized loadings of the items, it was seen that the item factor loadings were 0.40 and above, indicating sufficient factor loading. Cronbach's alpha coefficients were 0.91 for the positive attitudes subscale and 0.84 for the perceived importance subscale. The respondents also demonstrated an above-average overall score, with a mean of 3.40 (SD = 0.69).Conclusion The Turkish version of the scale provides a dependable measure of nursing students' positive attitudes toward wearable screens and how important they consider this technology for future educational use.

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