Sürdürülebilir Kalkınma Amaçları

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Araştırmacılar(16)

• Acet, Tuba
• Akar, Zeynep
• Aktaş, Esra
• Bayram, Hakan
• Doğanay, Fatma
• Düzgün, Azer Özad
• Efe, Ömer Faruk
• Ekti, Hatun
• Gökcan, Ahmet
• Güleşci, Nuri
• Günaydin, Mustafa
• Irmak, İbrahim
• Işık, Hale
• Kirma, Ramazan
• Sarıbıyık, Oğuz Yunus
• Şüküroğlu, Süleyman

• Yüksek Lisans TeziAçık Erişim2026/r/gumushane/20554
  Makroekonomik değişkenlerin iş kazalarına etkisi: Visegrad ülkeleri üzerine bir araştırma

  Aysun Yilmaz Akyol

  İstihdam, ekonomik büyüme ve sosyal refahın temel belirleyicilerinden biridir. Bununla birlikte, özellikle gelişmekte olan ülkelerde, ekonomik büyümeye odaklanan politikalar iş sağlığı ve güvenliği (İSG) uygulamalarının göz ardı edilmesine yol açabilir. Bu çalışma, 2013–2022 dönemini kapsayan yıllık veriler kullanılarak Visegrad Grubu ülkeleri (Çek Cumhuriyeti, Macaristan, Polonya ve Slovakya) iş kazaları üzerindeki makroekonomik değişkenlerin etkilerini incelemektedir. İş kazaları bağımlı değişken olarak kullanılırken, kişi başına GSYİH, işsizlik oranı, ticaretin açıklığı ve hukukun üstünlüğü bağımsız değişkenler olarak modele dahil edilmiştir. Analiz için Swamy Rastgele Katsayılar Modeli kullanılmıştır. Bulgular, kişi başına GSYH değişkeninin tüm ülkelerde iş kazalarının azalması üzerinde istatistiksel olarak anlamlı bir etkiye sahip olduğunu göstermektedir. Bu sonuç, ekonomik büyüme ve refah düzeyindeki artışın iş sağlığı ve güvenliği uygulamalarını güçlendirdiğini ortaya koymaktadır. İşsizlik oranının Çek Cumhuriyeti, Macaristan ve Slovakya’da iş kazaları üzerinde istatistiksel olarak anlamlı ve olumsuz bir etkiye sahip olduğu belirlenmiştir. Kurumsal kalitenin göstergesi olan hukukun üstünlüğü değişkeni, Çek Cumhuriyeti, Polonya ve Slovakya’da iş kazalarının azaltılmasında anlamlı sonuçlar vermiştir. Ticaret açıklığının Çek Cumhuriyeti ve Polonya'da iş kazalarını artırıcı yönde anlamlı bir etkiye sahip olması, artan uluslararası rekabet baskısının üretim yoğunluğunu artırarak iş sağlığı ve güvenliği uygulamalarını olumsuz etkileyebileceğini göstermektedir. Sonuç olarak, bu çalışmanın bulguları, iş kazalarının yalnızca teknik ve fiziksel risklerden değil, ekonomik ve örgütsel faktörlerden de etkilendiğini göstermektedir. Bu nedenle, iş kazalarını önlemeye yönelik politikaların, ekonomik koşullar ve iş sağlığı ve güvenliği uygulamalarını bütüncül bir yaklaşımla ele alması önem taşımaktadır.

  RDL DOI10.71008/gumushane.thesis.2026.205indekslendi
  İncele
• MakaleAçık Erişim2026/r/gumushane/19463
  Yapay Zekânın İş Güvenliği Uygulamalarındaki Kullanımına Yönelik Bibliyometrik Analiz

  Irmak, İbrahim; Aktaş, Esra

  Tarih boyunca çeşitli biçimlerde var olan iş güvenliği, Sanayi Devrimi ile birlikte daha kapsamlı ve sistematik bir şekilde incelenmeye başlanmış olup, günümüzde de hâlâ en önemli disiplinlerden biri olmaya devam etmektedir. Hızla değişen dünya ile birlikte kurum kültürleri ve dolayısıyla güvenlik kültürü de değişmekte ve iş güvenliğine yönelik yapılan değişimler teknoloji ile birleşmektedir. Yapay zekânın ve yapay zekânın alt disiplinleri olan makine öğrenmesi, derin öğrenme ve doğal dil işleme tekniklerinin iş güvenliği uygulamalarında kullanımı buna örnek verilebilmektedir. Bu kapsamda çalışmanın amacı, yapay zekânın iş güvenliği uygulamalarındaki kullanımına yönelik bir bibliyometrik analiz yapmak olarak belirlenmiştir. Analiz kapsamında veriler; 2 Nisan 2025 tarihinde Web of Science veri tabanından, yayın tarihi ve dil kısıtlaması olmaksızın, yalnızca araştırma makaleleri, konferans bildirileri, kitaplar ve kitap bölümleri yayın türü olarak seçilerek elde edilmiştir. Çalışmada belirlenen anahtar kelimeler doğrultusunda, 1519 bilimsel çalışma incelenmiş; yayın çıktısı ve büyüme eğilimleri, coğrafi dağılım, kurum, yazar, atıf ve anahtar kelime analizleri yapılmıştır. Sonuç olarak, iş güvenliğinde yapay zekânın kullanımına yönelik bir rapor sunulmuştur.

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  İncele
• MakaleYalnız künye2026/r/gumushane/13816
  Covalent Immobilization of Glutathione-S-Transferase onto Magnetic Iron Nanoparticles via Epichlorohydrin Spacer Arm

  Kemal Caglar, M.; Gulesci, Nuri; Bilgin, Ramazan; Yucebilgic, Guzide

  This study examined the synthesis of Fe₃O₄ magnetic nanoparticles (MNPs) and the covalent immobilization of glutathione-S-transferase (GSTs) onto these nanoparticles using an epichlorohydrin (ECH) spacer arm, as well as the optimal reaction conditions for both free and immobilized enzymes and the reusability of the immobilized enzyme. The optimal pH values for free and immobilized enzymes were established as 7.0 and 6.0, respectively. It was found that the ideal temperature for both free and immobilized enzymes was 37 and 40°C, respectively. Under the optimum conditions, the values of V_max for glutathione (GSH) and 1-chloro-2,4-dinitrobenzene (CDNB) substrates of free GSTs enzyme were measured as 204.8 U/mg prot. and 194.3 U/mg prot., respectively. The immobilized GSTs enzyme's CDNB and GSH substrates had V_max values of 33.29 U/mg prot. and 33.08 U/mg prot., respectively. The free GSTs enzyme's CDNB and GSH substrates have K_m values of 0.201 mM and 0.1873 mM, respectively. GSH and CDNB have K_m values of 0.3042 mM and 0.2523 mM, respectively. At various temperatures, we contrasted the thermal stability of free and immobilized GSTs. The immobilized GSTs enzyme retained 50% of its activity after 20 reuses. After 30 days of storage at 25°C and 4°C, it was discovered that 18% and 32% of the free GSTs enzyme activity were preserved, and 30 days of storage at 25°C and 4°C resulted in 20% and 41% preserved enzyme activity for the immobilized enzyme, respectively.

  İncele
• MakaleYalnız künye2026/r/gumushane/13782
  Investigation of the adhesion properties of duplex coating on AZ91 alloy surface by MAO/HiPIMS-PVD methods

  Kaplan, Emine Boynueğri; Şüküroğlu, Süleyman; Şüküroğlu, Ebru Emine

  This study focuses on enhancing the surface properties and minimizing the mechanical incompatibility between the AZ91 magnesium alloy and the coating by applying CrAlYN/CrYN gradient coatings through the HiPIMS-PVD method, combined with the enlargement of a MgO intermediate layer via the Micro Arc Oxidation (MAO) method. The duplex coating approach was designed to strengthen adhesion and structural integrity between the substrate and the coating. Coating parameters for both MAO and HiPIMS-PVD processes were optimized using a Taguchi L4 orthogonal array, and the coatings were analyzed using SEM, EDS, XRD and scratch testing. MAO coatings exhibited porous and rough surfaces with volcanic morphologies. The best adhesion performance under MAO conditions was achieved with 650 V, 700 Hz, and a Type B solution, resulting in a critical load value of Lc₂ = 24 N. CrAlYN/CrYN gradient coatings alone showed coating thicknesses from 0.83 μm to 1.66 μm with compact and homogeneous microstructures. Adhesive strength was relatively low (Lc₂ = 5–10 N). In the duplex coating configuration, CrAlYN/CrYN coatings were deposited on the MAO-formed MgO layer, significantly increasing adhesion. Critical load values (Lc₂) ranged from 90 to 110 N, with the highest adhesion achieved under low CrY target voltage and current conditions. The findings demonstrate that the MAO/HiPIMS-PVD duplex coating method substantially improves adhesion and surface characteristics of AZ91 alloy, offering a promising solution for advanced surface engineering applications.

  İncele
• MakaleYalnız künye2026/r/gumushane/13777
  Synthesis, characterization, and thermal-magnetic evaluation of novel triazine-derived polyamides and their metal complexes

  Çanakçı, Dilek; Sarıbıyık, Oğuz Yunus

  In this work, novel triazine-containing polyamide derivatives possessing thermal stability and magnetic properties were synthesized. The synthesis process involves two steps: first, the chlorination of adipic acid and succinic acid using thionyl chloride; and second, the amidation of triazine. As a result of these procedures, two different triazine-containing polyamides were synthesized. The synthesized polyamides formed complexes with Ag, Cu, and Zn ions to enhance their thermal stability and magnetic properties.The structures of the synthesized polyamides were elucidated primarily by FTIR analysis, focusing on distinctive bands corresponding to the carbonyl group. The molecular structures of the polyamides were confirmed using 1H NMR and 13C NMR spectroscopy. Scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM-EDX) was employed to obtain information on the morphology and elemental composition of the samples. In addition, X-ray diffraction (XRD) analysis was performed to characterize the crystal structures, unit cell parameters, and orientations of the solid-state metal complexes. The thermal stability of both the polyamides and their metal complexes was investigated using thermogravimetric analysis (TGA). The magnetization of the synthesized compounds was measured as a function of temperature under zero-field-cooled (ZFC) and field-cooled (FC) conditions using a physical property measurement system (PPMS).

  İncele
• MakaleAçık Erişim2026/r/gumushane/13767
  Whole-genome characterization of clinical Enterococcus faecalis and Staphylococcus epidermidis Isolates reveals mecA-positive E. faecalis and a shared lnu(A)–rep7a resistance plasmid in Türkiye

  Ejder, Nebahat; Özad Düzgün, Azer

  Background: This study aimed to genomically characterize clinical Enterococcus faecalis and Staphylococcus epidermidis isolates obtained from aspirate and sputum samples at Bayburt State Hospital, focusing on antimicrobial resistance genes, virulence factors, and mobile genetic elements. Methods: Whole-genome sequencing (WGS) was performed on the isolates, and antimicrobial resistance genes, virulence determinants, multilocus sequence types (MLST), plasmid replicons, and mobile genetic elements were identified using bioinformatics tools. Results: The E. faecalis E5 (ST64) isolate, recovered from an aspirate sample, carried multiple antimicrobial resistance genes, including mecA, vanT, erm(B), tet(M), and qacA, along with a diverse virulence gene repertoire (cyl, ebp, ace, and agg), mobile genetic elements (Tn6009, ISL1a3), and four plasmid replicons (rep19C, rep9C, repUS43, and rep7a). The E. faecalis E184 and E187 isolates (ST124), obtained from sputum samples, harbored fewer acquired resistance genes but shared gyrA (T672A) and parC (V307I) mutations associated with fluoroquinolone resistance. The S. epidermidis ST59 isolate carried resistance genes lnu(A), fosB, and qacD, together with the plasmid replicon rep7a and insertion sequence ISSau4. The co-occurrence of lnu(A) and the rep7a plasmid in both species suggests a potential pathway for interspecies transmission of resistance determinants. Conclusions: This study reports the genomic detection of mecA in an E. faecalis isolate from Türkiye based on WGS analysis. However, this finding is based solely on genomic data and lacks phenotypic or experimental validation. The detection of a shared plasmid-associated resistance element (lnu(A)–rep7a) in both E. faecalis and S. epidermidis highlights the potential for interspecies resistance gene flow within the hospital environment.

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  İncele
• MakaleAçık Erişim2026/r/gumushane/13623
  Layered Polymeric Carbon Nitride as a Green Support for Cellulase Immobilization: Improved Stability, Activity, and Reusability

  Gulesci, Nuri; Altan, Orhan; Toprak, Ali; Yalçın, M. Serkan; Bilgin, Ramazan; Yildirim, Deniz

  Polymeric carbon nitride (PCN) has attracted considerable attention in recent years due to its layered structure and donor groups such as terminal amines and triazine units. In this study, PCN was synthesized from melamine and employed for the first time as a support material for the immobilization of cellulase, a key enzyme used in numerous industrial applications. Transmission electron microscopy (TEM) analysis revealed that ranged from 219 to 375 nm in size, thereby confirming their nanoscale layered morphology. Cellulase from Aspergillus sp. was immobilized onto PCN using three methods. In the first approach, cellulase was adsorbed onto PCN to form PCN@cellulase. In the second method, PCN@cellulase was cross-linked with glutaraldehyde (PCN@cellulase/Glu). Finally, the primary amino group of PCN was modified with glutaraldehyde, and the cellulase was immobilized onto this support via covalent attachment (PCN/Glu@cellulase). Each cellulase preparation was assessed for its optimal pH, temperature conditions, thermal stability, and enzyme kinetics. The optimal pH was 5.5 for all cellulase preparations, while the optimal temperature was 45 °C for free cellulase and 55 °C for all immobilized cellulase preparations. Thermal stability of PCN@cellulase, PCN@cellulase/Glu, and PCN/Glu@cellulase increased by 2.1-, 2.7-, and 3.7-fold, respectively, compared to the free cellulase. PCN/Glu@cellulase showed a 1.4-fold higher catalytic efficiency than the free cellulase and retained 80% of its initial activity after 10 reuses. This work highlights PCN as a green, metal-free, and easy-to-prepare support for enzyme immobilization, thereby opening new possibilities for sustainable bioprocessing applications.

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  İncele
• MakaleYalnız künye2026/r/gumushane/13616
  Purification of catalase enzyme from Thymus nummularius and examination of the effects of varying glucose concentrations on catalase activity

  Toprak, Esma; Güleşci, Nuri

  Catalase (EC 1.11.1.6), an antioxidant enzyme, breaks down reactive oxygen species, hydrogen peroxide (H2O2), into water and oxygen. In this study, the partial purification of catalase was obtained from Thymus nummularius M. Bieb. through ammonium sulfate (NH4)2SO4 precipitation, dialysis, and desalting/buffer exchange by using a PD-10 Sephadex G-25 M column. The isolated enzyme had a specific activity of 1294.45 U/mg protein and a purification fold of 7.80. The SDS-PAGE analysis indicated a molecular weight ranging between 37 and 50 kDa. The optimal pH and temperature for catalase activity were determined to be pH 8.0 and 25 °C, respectively. The kinetic parameters, maximum velocity (Vmax) 277.78 U/mL and Michaelis constant (KM) 34.17 mM were estimated from Lineweaver-Burk plots. Furthermore, catalase activity was evaluated at glucose concentrations ranging between 25 and 500 ppm. Enzyme activity increased at 25–100 ppm, significantly decreased at 250 ppm, and then increased again at 500 ppm. These results suggest that glucose may modulate catalase activity in a concentration-dependent manner. Even though the exact regulatory mechanism remains unclear, this effect could have potential implications for glucose-sensitive metabolic systems.

  İncele
• MakaleYalnız künye2026/r/gumushane/13472
  Effects of sunlight ripening process on the biological activities of persimmon (Diospyros kaki L.) peel and pulp extracts

  Kardil, Uğur; Akar, Zeynep; Düzgün, Azer Özad

  The aim of the study was to evaluate the biological properties of the peel and pulp extracts of persimmons, with consideration of the impact of different ripening conditions (B: on-branch ripened and S: sunlight ripened). The data demonstrated that the sunlight ripened persimmon peel (S. peel) extract exhibited a higher total phenolic and flavonoid content, with 157 and 7.3 µg/mL GAE respectively. The S. peel extract exhibited the highest antioxidant activity, exhibiting 1.1578 mg/mL IC50, 54.095 and 0.0262 µM Trolox equivalent (TE)/g fresh weight (FW), as determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH•) radical scavenging assay, ferric reducing antioxidant power (FRAP) and cupric reducing antioxidant capacity (CUPRAC) respectively. LC-MS/MS analysis revealed that the peel and pulp phenolic composition of persimmon ripening process different conditions changed. The activity of protocatechuic, chlorogenic, caffeic and ferulic acids identified in persimmon extracts was determined by HPLC-DAD-FRAP assay. ICP-OES analysis revealed that potassium exhibited the highest mineral content of persimmon, with values ranging from 575.680 to 2031.360 mg/kg. The S. peel extract was more inhibitory activity against bovine carbonic anhydrase (BCA) and α-glucosidase then other extracts. Moreover, the S. peel extract was found to demonstrate the highest level of antibiofilm activity, reducing the strong biofilm formation capacity of the A. baumannii isolate to negative, both qualitatively and quantitatively. The study suggests that the ripening of persimmon fruit in sunlight may increase biological activity and may be useful in the prevention and treatment of diseases associated with oxidative damage, diabetes and bacterial infections.

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  İncele
• MakaleAçık Erişim2026/r/gumushane/12273
  Antibacterial Efficiency and Osteoblast Viability of Ag/AgO/Ag2O Nanoparticles on Microarc-Oxidized TiO2

  Aktas, Sitki; Durdu, Salih; Bird, Toby W.; Ozcan, Kadriye; Yigitturk, Gurkan; Aktug, Salim Levent; Usta, Metin; Acet, Tuba; Pratt, Andrew

  Infections associated with titanium-based medical and dental implants present a major clinical challenge, as they can compromise osseointegration and long-term implant stability. Silver-based nanoparticles (NPs) are widely recognized for their strong antimicrobial properties, and when combined with titanium, they hold significant promise for developing infection-resistant and biocompatible implant surfaces. In this study, Ag/AgO/Ag2O NPs were deposited onto highly porous TiO2 layers formed on the Ti6Al4V alloy by microarc oxidation (MAO), with the aim of simultaneously enhancing antibacterial performance and supporting osteoblast activity. The NPs exhibited a predominant size of 8.7 ± 0.1 nm, with smaller particles oxidized to AgO and Ag2O, and larger particles (∼10 nm) composed of metallic Ag. SEM evaluation revealed that the NPs were homogeneously dispersed across the oxide surfaces without altering the rough and porous morphology of TiO2. The MAO-treated surfaces initially showed hydrophobic behavior (contact angle of 94.1 ± 0.3°), which shifted to hydrophilic after Ag/AgO/Ag2O NP deposition due to increased hydroxyl group formation. Antibacterial assays against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) revealed a significant enhancement in antibacterial activity, particularly for surfaces with the highest Ag/AgO/Ag2O NP density. Meanwhile, osteoblast cell viability assays demonstrated no reduction in metabolic activity after 72 h, and SEM images confirmed cell adhesion and proliferation. Overall, these findings highlight the potential of Ag/AgO/Ag2O NP-modified TiO2 surfaces as multifunctional coatings that combine infection resistance with osteoblast compatibility, offering promising applications in dental and orthopedic implants.

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