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- Uzun, Sevda(79)
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Yayınlar
- MakaleAçık Erişim2021Investigation the Different Extraction Temperature Effect of Artvin Savsat Region Propolis PBS Extracts on Antioxidant Properties and Eryhrocyte Hemolysis Inhibition
Canbolat, Deniz; Turan, Ibrahim; Küpeli, Yunus Emre; Kilinç, Sedanur; Piliç, Sevim
Propolis, which has been used in traditional medicine for hundreds of years all over the world, is a resinous natural product with a complex content obtained by honey bees by mixing the buds of plants and pollen grains with enzymes they secrete. Propolis may have different contents due to the gathering region, plant source, bee variety and climate of the place where it is collected. Although there are many studies related to different regions, so far the propolis of the Savsat region in Artvin have not been studied yet. The aim of this study is to determine the antioxidant properties (determination of iron reducing power, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, total phenolic and total flavonoid content) of propolis extracts of Artvin Savsat region prepared with phosphate buffer salt solution (PBS) prepared at different temperatures (45 and 60 degrees C) and to determine the erythrocyte hemolysis inhibition properties of the extracts. Total phenolic (11.91 +/- 0.5-24.14 +/- 1.38 mg gallic acid equivalent to g propolis) and total flavonoid (1.79 +/- 0.03-2.13 +/- 0.07 mg quercetin equivalent to g propolis) content of PBS extracts, iron power determination (12.80 +/- 0.36-27.15 +/- 0.12 mg ascorbic acid equivalent to g propolis), 2,2-diphenyl-1-picrilhydrazyl (DPPH) radical scavenging activity (%22.86 +/- 0.5-31.24 +/- 1.33) and erythrocyte hemolysis inhibition (%55.58 +/- 0.57-96.37 +/- 0.02) were determined using spectrophotometric methods. As a result of the experiments, it was determined that the extract with PBS obtained at a temperature of 60 degrees C was higher than the extract obtained at 45 degrees C, in terms of antioxidant properties and erythrocyte hemolysis inhibition ratio. Further studies are required to identify molecules that inhibit erythrocyte hemolysis in extracts and have antioxidant properties.
AtıfWoS4OpenAlex9TR Dizin5
İncele - MakaleAçık Erişim2021A Research on The Relationship Between Social Media Disorder, Religiosity and Moral Disengagement In Adolescents
Hacikelesoglu, Hizir
Moral disengagement is a phenomenon that is at the centre of life in terms of being frequently referred to in social life. The fact that young people (as moral agents) are at the centre of criticism on moral issues makes it necessary to examine the areas in which young people are engaged and affected during this period. In this context, the present study aims to examine the relationship between social media addiction, religiosity and moral disengagement on a sample group of individuals aged 13-18. For this purpose, the research was designed according to the relational screening model, one of the quantitative research methods. The research data were collected through a sample group consisting of 415 people selected by the convenience sampling method. In the analysis of the obtained data, correlation and regression analyzes were performed by using SPSS 21. As a result of the research, there is a positive relationship between social media addiction and moral disengagement. On the other hand, a negative relationship was found between religiousness and moral disengagement. It has been determined that social media addiction and religiousness predict moral disengagement in opposite directions. In addition, it has been observed that religiosity is not a determining factor on social media addiction.
AtıfWoS5OpenAlex20TR Dizin15İncele - MakaleAçık Erişim2021A Sociological Criticism of the Global Health Discourse: The Pandemic as a Metaphor of Contemporary Culture
Demir, Sertac Timur
This article argues that a clear correlation exists between disease and the prevailing social functioning. In this respect, every disease can be seen as a metaphor for the age and society in which it emerges. In other words, every period carries a form of disease that bears traces of the dominant lifestyle. This study approaches the epidemic as a kind of sociological projection in the context of studying modern culture and continues the discussion along the lines critically opened by Susan Sontag (2005). lust as Sontag examined disease as a metaphor, this article debates the discourses on masks, social distancing, and hygiene within the scope of COVID-19 along a specific sociological axis around the concepts of speed, control, information, hyper-medicalization, and death as the dominant indicators of contemporary culture. For this purpose, the study seeks answers to the following questions through the leading social theorists of the field such as Bauman, Baudrillard, Turner, Furedi and Chul-Han: How does the global epidemic and the current health discourse embodied in it appear within the sociological context? What thoughts and tendencies emerge when examining the pandemic portrait as a social metaphor? For example, what kind of relationship exists between hygiene and cultural fears; among distance, social isolation, and avoidance; and between masks and the superficial idea of death concealed behind quantification? Undoubtedly, the pandemic is a critical breaking point in the history of modern medicine and has forced not only global health practices but also many value judgments to both paradoxically be accepted and questioned.
AtıfOpenAlex1TR Dizin1İncele - BildiriAçık Erişim2021Automatic Sleep Scoring System Based On Autoregressive Model
Melek, Mesut
Electroencephalography (EEG) signals recorded during sleep are divided into 30-second segments and analyzed by experts and classified into sleep stages, and in this way, diagnosis and treatment of diseases are made. Computer-assisted sleep scoring systems can effectively reduce the burden of experts by classifying sleep stages. In this study, after preprocessing of the EEG signals, four features were obtained for each EEG band (20 features in total) with the autoregressive model and then classified with three different classifiers common in machine learning. The proposed method was tested on the data set called ISRUC sleep (Subgroup 3, ISRUC3) and the results were compared with the results of other studies. The results show that the proposed method is more successful than other existing methods, despite the use of fewer features.
AtıfOpenAlex1İncele - MakaleYalnız künye2021Scopus SJRQ3Time interval between E and E′ waves can predict complicated clinical course in patients with acute pulmonary embolism
Acar, Emrah; Kilicgedik, Alev; Izci, Servet; Inanir, Mehmet; Yilmaz, Mehmet Fatih; Gokce, Mustafa; Izgi, Ibrahim Akin; Kirma, Cevat
Purpose Acute pulmonary embolism is a life-threatening cardiothoracic emergency leading to right ventricle systolic and diastolic dysfunction. In the present study, we investigated the right ventricle diastolic function and its predictive value in patients with acute pulmonary embolism. Material and methods Were prospectively recruited in this study 621 patients diagnosed with acute pulmonary embolism between December 2015 and June 2019. Among them, 173 were excluded, leaving 448 patients for follow-up. Transthoracic echocardiography was performed for the evaluation of the right ventricle systolic and diastolic indices. At 30-day follow-up, the patients were allocated either into the benign or in the complicated clinical course group. Results The group with complicated clinical course had higher value of pulmonary artery systolic pressure (PASP), right/left ventricle diameter ratio, E-wave velocity, E/A ratio, A ' wave velocity, E/E ' ratio, and time interval between E and E ' waves (P < .05), but lower values of tricuspid annular plane systolic excursion, A-wave velocity, isovolumetric relaxation time, deceleration time, E ', and E '/A ' (P < .05). Complicated clinical course was associated with shorter isovolumetric relaxation time (r = .564, P < .001), E/E ' (r = .495, P < .001), and TE-E ' (r = .596, P < .001). Receiver operator characteristic curve analysis showed that TE-E ' had the largest area under curve (TE-E ' 0.82, IVRT 0.77, E/E ' 0.72). A cut-off value of TE-E ' = 70 milliseconds had an 81.1% sensitivity and 71.4% specificity for the prediction of the complicated clinical course. Conclusion The assessment of the right ventricle diastolic function could predict the complicated clinical course in patients with acute pulmonary embolism.
AtıfWoS3OpenAlex3
İncele - MakaleYalnız künye2021Scopus SJRQ1Rationally decreasing the number of drugs seems to be a useful therapeutic approach in older adults: 6-month follow-up study
Idil, Eral; Aydin, Ali Ekrem; Bulut, Esra Ates; Isik, Ahmet Turan
Aims: Older adults are at risk for polypharmacy, which has multidimensional safety, clinical and economic implications. Therefore, the optimization of drug therapy is one of the critical components of geriatrics clinical practice. This study is aimed to investigate the effect of drug rationalization on comprehensive geriatric assessment(CGA) parameters. Materials and Methods: The study was a retrospective and longitudinal study examining the effect of change in drug number on functionality and physical performance. A total of 515 patients were included in the study. Detailed medication history, laboratory findings, CGA parameters were recorded in the first admission. Polypharmacy was accepted as concurrent usage of five or more drugs. Medications of each patient were reviewed with the guidance of CGA and Beers Criteria. Results: The mean age of patients was 74.13 +/- 7.29 years, and 68.7% were female. The baseline mean number of drugs was 5.11 +/- 3.34. The polypharmacy group(269 patients) had a higher rate of geriatric syndromes and lower CGA scores in the first admission. After optimization of medications, the mean drug number decreased to 4.76 +/- 2.72. Depression, mobility and nutritional scores improved at the end of six months in the patients whose total number of drugs decreased, while global cognition, activities of daily living scores, and gait speed were preserved. Increasing the number of drugs was associated with lower mobility and functionality. Conclusion: Drug rationalization guided with CGA improves the nutritional, physical, and psychosocial status of geriatric patients. Thus, medication reviews have key importance in the management of older patients.
AtıfWoS17OpenAlex19İncele - MakaleYalnız künye2021Scopus SJRQ2Osteoclastic activity in chronic otitis media with cholesteatoma-related bone destruction
Özgur, A.; Yemis, T.; Basbulut, E.; Turgut, N. F.; Özdemir, D.; Akgul, G.; Mehel, D. M.; Celebi, M.
Background Cholesteatoma-related bone destruction is the cause of many complications due to chronic otitis media. This study aimed to evaluate osteoclastic activity in cholesteatoma-related bone destruction using tartrate-resistant acid phosphatase 5b, an enzyme specific to osteoclastic activity. Method Seventy-two patients diagnosed with chronic otitis media were included in this study and were divided into two groups: with and without bone destruction. The blood serum and tissue tartrate-resistant acid phosphatase 5b levels from both groups were compared. Results There were no significant differences in the level of serum enzymes between both groups. However, in tissue samples, tartrate-resistant acid phosphatase 5b levels were significantly lower in the bone destruction group than the group without bone destruction. Conclusion This study determined that the level of tartrate-resistant acid phosphatase 5b, a specific enzyme for osteoclastic activity in cholesteatoma-related bone destruction, is locally decreased. This data suggests that osteoclastic activity may decrease in cholesteatoma-related bone destruction. However, further experimental and clinical studies are required to clarify this highly complex mechanism.
AtıfWoS4OpenAlex4İncele - MakaleYalnız künye2021Scopus SJRQ3Comparison of the effects of operating microscopes with light emitting diode and halogen light source on the eye: a rabbit study
Aydin, Bahir; Ozgur, Armagan; Ozdemir, Huseyin Baran; Inan, Mehmet Arda; Atalay, Hatice Tuba; Bayrakceken, Kemal; Ozmen, Mehmet Cuneyt; Ucgul, Ahmet Yucel; Gocun, Pinar Uyar
Purpose To evaluate the potential toxicity of operation microscopes with halogen and light emitting diode (LED) light source on the rabbit eyes. Materials and methods Thirty-two eyes of 16 male New Zealand pigmented rabbits were involved in the study. The rabbits were divided into two groups according to the type of light source applied. Only one eye of each rabbit was exposed to illumination light, unexposed fellow eyes served as the control group. Experimental groups included group 1 exposed to halogen light for 2 h and evaluated 1 day and 1 week after the illumination, group 2 exposed to LED light for two hours and evaluated 1 day and 1 week after the illumination. On the first and seventh days after exposing the light, we evaluated the rabbit corneas using in vivo confocal microscopy (IVCM). At the end of the seventh day, the Hematoxylin-eosin staining and TUNEL staining were performed to investigate the presence of apoptosis in the retina and retina pigment epithelium. Results Early IVCM findings revealed corneal epithelial cell ovalization and indistinct intercellular borders in the halogen light group. We also observed more increase in the keratocyte density index (23.7% vs 14.1%, p = 0.001, respectively) and the Bowman reflectivity index (12.4% vs 4.1%, p = 0.001, respectively) at first day of the light exposure in halogen light group compared to LED light group. However, late IVCM indicated that these findings disappeared one week later. No apoptosis was observed in the corneal and retinal layers in early and late examination groups. Conclusion The present experimental study demonstrated that both halogen and LED lights, which were commonly used for microscopic eye surgery, had no sustained adverse effect on the cornea and retina of the rabbits; however, halogen light had a temporary adverse effect on corneal epithelium and stroma, which resolved within 1 week.
AtıfWoS2OpenAlex5İncele - MakaleAçık Erişim2021Urologists' Role and Attitude in the Systemic Treatment of Urologic Cancers
Madendere, Serdar; Deger, Muslim Dogan; Demirkiran, Engin Denizhan; Yildiz, Huseyin Alperen
Objective: The goal of this study was to investigate Turkish urologists' role and attitude toward the systemic treatment of urologic cancers. Materials and Methods: An 18-item survey was e-mailed to 2305 certified Turkish urologists. The survey included questions designed to evaluate urologists' knowledge of chemotherapy procedures and their ability to manage complications, as well as how many of them perform systemic therapies and believe urologists should perform these therapies for urologic cancers. Results: We evaluated 305 responses. Most urologists (89.6%) perform hormonotherapy for prostate cancers. Further, the majority refer patients to medical oncologists for chemotherapy. Moreover, 65.9%, 70.8%, and 72.1% of the urologists believe that only medical oncologists should deliver chemotherapy for prostate, bladder, and testicular cancers, respectively. Only 23.9% of urologists believe they are competent to perform chemotherapy, while 16.7% believe they are capable of dealing with chemotherapy complications. Conclusion: Turkish urologists have a lack of performance and interest in administering systemic therapies in urologic cancers. We want to emphasize that urology is more than just surgery. Urologists should be involved in all stages of cancer treatment.
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2021Scopus SJRQ3Treating surgical site infection following posterior instrumentation with free-style deepithelialized propeller flap: A case report
Datli, Asli; Karasoy, Ismail; Zeynal, Mete
Surgical site infection is a challenging situation for all types of surgeons. Extensive debridement with or without implant removal can create soft tissue defects. A well-vascularized, adequate soft tissue is needed to cover the wound and to fill the dead space for proper healing. Herein, we describe our approach to a large posterior trunk defect with dead space and our solution to manage an intraoperative complication using a free-style deepithelialized propeller flap.
- Derleme MakaleAçık Erişim2021Scopus SJRQ4The New Disease of the Modern Age: What Is the Fear of Missing Out FOMO? A Review
Erdogan, Ali; Yilmaz, Yavuz; Hocaoglu, Cicek
Social networks have become a very important part of human life in recent years. This situation has led to new definitions such as the Fear of Missing Out (FOMO). FOMO can be defined as the concern that others can have a good experience when the person is absent and therefore the person wants to stay on social networks constantly to avoid missing anything. It is especially common in young people. Problematic internet use, psychosocial factors, social network use and anxiety are blamed in its etiology. Family conflicts, loneliness, depression, and low self-efficacy can be said as risk factors. People constantly want to spend time on social networks, daily life activities are blocked and the person's productivity decreases. It has no place in diagnostic classifications. For FOMO, the fear of missing out scale developed by Przybylski can be used. It is reported that FOMO has a significant positive relationship with nomophobia. There is no specific treatment method. There is a need for extensive research on FOMO.
AtıfWoS2OpenAlex3İncele - MakaleAçık Erişim2021The Effect of Rosa pimpinellifolia Extract on the Proliferation of Human Tumor Cells
Demir, Elif Ayazoglu; Demir, Selim; Türkmen, Nihal; Turan, Ibrahim
The aim of this study was to evaluate the antioxidant properties of R. pimpinellifolia and its cytotoxic effect against human colon (WiDr), liver (HepG2) and lung (A549) cancer cells compared with a normal fibroblast (BJ) cell line. The antioxidant properties of extract was determined using spectrophotometric methods, while the cytotoxic effect of extract was evaluated using MTT assay. The total phenolic content, total flavonoid content and reducing power values of extract were calculated as 16.4 +/- 0.4 mg gallic acid equivalent, 5.2 +/- 0.2 mg quercetin equivalent and 34.3 +/- 2.4 mg trolox equivalent per g sample, respectively. Although the extract exhibits selective cytotoxic effect on three cancer cell lines in a dose-dependent manner compared to BJ cells, the highest selectivity index value (2.7-fold) was obtained for the WiDr cell line. In conclusion, this is the first study to demonstrate the cytotoxic effect of R. pimpinellifolia on cancer cells. To demonstrate the molecular mechanism of this cytotoxic effect and to carry out in vivo studies may be a guide for future clinical studies.
AtıfWoS3OpenAlex5TR Dizin1İncele - MakaleAçık Erişim2021Evaluation of Cytotoxic Effect of Onosma armeniacum Extract on Various Cancer Cells
Demir, Selim; Ayazoglu Demir, Elif; Turan, Ibrahim; Özgen, Ufuk
The aim of this study was to investigate the antioxidant properties of the root extract of Onosma armeniacum and its cytotoxic effect against human liver (HepG2), lung (A549) and colon (WiDr) cancer cell lines compared with a normal fibroblast cell line. Antioxidant properties of the extract was determined using the colorimetric methods. The cytotoxic effect of the extract were investigated using MTT assay. The total phenolic content and reducing power values of extract were 26.1 +/- 0.4 mg gallic acid equivalent and 52.6 +/- 1.1 mg trolox equivalent per g sample, respectively. The extract exhibited selective cytotoxic effect in all studied cancer cell lines, especially HepG2 (3.6-fold). The results of this study reveal that O. armeniacum, which has been found to have acceptable antioxidant and cytotoxic effects, should be examined with more comprehensive studies.
AtıfWoS8OpenAlex12TR Dizin1İncele - MakaleAçık Erişim2021Men's Choice of Contraception Method
Ozcan, Handan; Yigitbas, Cagla; Karaca, Mucahit Talha
Objective: The aim of this study is to examine the contraception choices of men, aged between 18-60 and living in the center of a province in the Gumushane. Methods: The study is of a descriptive type. As a data collection form, an Individual Information Form consisting of a total of 32 questions was used. This form questions the demographic-physical-biological-social-health histories of the participants and their knowledge, attitudes, behaviors about contraception methods. Averages were given together with standard deviations. Results: 20.8 % of the participants are aged between 26-33. It was seen that 25.3% of the participants had knowledge about contraception methods and 64.7% did not use any methods. When the variables of the age and the marital status are approached in terms of having sufficient knowledge about contraception and still using contraception methods, there is a statistical significance between the variable of 'is the use of contraception methods harmful to health?' with the status of still using contraception methods. A statistical significance is also found between the variable of being sexually active with the status of having sufficient knowledge about contraception and still using contraception methods (p<0.05). Conclusion: In this study, It has been determined that men who had sufficient information about contraceptions had higher age and higher education levels, were sexually active and married. It has been seen that the age, the marital status, the perception of contraception as harmful to health, the status of being sexually active did not affect receiving any training about contraception.
- BildiriAçık Erişim2021Investigation of In-Vitro Properties of NiTi Alloy After Micro Arc Oxidation
Süküroglu, Suleyman; Totik, Yapr; Süküroglu, Ebru Emine; Küçükosman, Ridvan
As material science is integrated into medical science as in other fields, the variety, development and usage areas of biomaterials increase. One of the biomaterials in this variety is NiTi alloys. This study was focused on the coating of TiO2 layer by using the method of Micro Ark Oxidation with the aim of the improvement of surface and mechanical properties of Shapedmemory and bio material NiTi alloy. Structural properties of the coatings were analysed by of SEM and XRD. In vitro ability was investigated by soaking the coated NiTi samples in simulated body fluid (SBF) at temperature 37 degrees C for various time periods. After soaking, Ni+2 release was applied to the media where coated and uncoated shape-memory NiTi samples are available, and its control was made by means of ICP-MS device. The results also show that Toxic and carcinogenic effects of Ni+2 release is significantly reduced by the TiO2 coating. Thus, it is observed that the properties that limit the use of NiTi alloys has been substantially fixed by MAO coating. It was found that the bioactive properties of the TiO2 coated NiTi substrate increased by MAO method and at the end of the 72 hour, there was no statistically any cytotoxicity in cell viability compared to the NiTi substrate.
AtıfWoS3OpenAlex2İncele - MakaleYalnız künye2021Scopus SJRQ1Challenges of Setting up a Lower Extremity Reconstruction Practice in a Constrained Environment
Datli, Asli; Karasoy, Ismail; Genc, Yucel; Pilanci, Ozgur
Background Microsurgical lower extremity reconstruction remains challenging, especially when resources are limited such as lack of proper equipment, human resources, administrative support, and located in a remote area far from tertiary care. Nevertheless, reconstructive solutions are required, especially when in urgent trauma situations. In this article, we evaluate ways of overcoming challenges and issues that should be considered in a newly established unit by sharing our initial lower extremity reconstruction experience. Methods We report a local hospital's initial lower extremity reconstruction experience in February 2017 to January 2018. Through a total of seven patients, we tried to enhance the environment, instruments, nurses' contribution, and perspective of the peers and community in terms of factors related to the surgeon, hardware, environment, supporting faculty, reimbursement, and patients. Results Four patients underwent reconstruction with a freestyle propeller flap and three with an anterolateral thigh flap; in one case, a superficial circumflex iliac artery perforator flap was chosen to salvage partial flap necrosis. Increased experience of the surgeon, new equipment, continuing nurse/patient education, and collaborating with other departments allowed us to choose more challenging flaps and be more meticulous while decreasing the operation time and hospital stay. Conclusion To start a lower extremity reconstruction practice in a resource-poor environment, the surgeon needs to evaluate the relevant factors; moreover, he or she should continuously improve them until a working methodology is achieved. Despite all the challenges, the adaptations learned at this center can be applied to other local hospitals around the world to set up a lower extremity reconstruction practice and improve its outcomes.
AtıfWoS4OpenAlex4İncele - MakaleAçık Erişim2021Effect of precautionary and normalization steps on course of COVID-19 pandemic in Turkey
Bostan, Sedat; Agac, Gokhan; Sahinöz, Saime
Aim: The COVID-19 pandemic began in China and has now spread across the whole world, and many countries such as Turkey are still fighting against this pandemic. The aim of this study was to investigate the impact of precautionary and normalization steps taken by the Turkish government on the number of confirmed cases, current cases, and deaths due to the COVID-19 in Turkey. Materials and Methods: The study used exponential regression models to estimate the number of confirmed cases, deaths, and current cases. The study data were collected from the Turkish Ministry of Health, Turkish Ministry of Internal Affairs, and the national public broadcaster of Turkey. Results: The precautions taken during the COVID-19 pandemic have caused the exponentially increasing number of cases to be brought under control and to decrease exponentially. The normalization steps taken paused the exponential decrease in the number of cases and caused the number of cases to remain flat during the summer months and then rise again. If the normalization steps were not implemented and the precautions taken continued in the same way, it was calculated that the numbers of COVID-19 current cases would be reset on June 26, 2020. The total number of deaths would remain at 4423 and the total number of confirmed cases would be 150586. Discussion: As a result, the impact of precautionary and normalization steps on the course of the COVID-19 pandemic was examined. It has been observed that the impact of these steps on the pandemic is exponential. The results provide guidelines for health authorities and administrators to take necessary precautions.
AtıfWoS1OpenAlex2İncele - MakaleAçık Erişim2021Diabetes Risk Assessment with Blood Parameters of The First Degree Relatives of Patients with Type-2 Diabetes Mellitus
Demirag, Hatice; Boyraz, Sakine
Objective: This study was conducted to evaluate the diabetes risk in first degree relatives of Type-2 diabetic patients who were not diagnosed with diabetes and test the validity of the Finnish Diabetes Risk Score (FINDRISK) in determining the risk of type-2 diabetes. Methods: First degree relatives of patients who were hospitalized in Izmir Katip Celebi University Ataturk Training and Research Hospital, who were not diagnosed with diabetes before, were included in this cross-sectional study. The sample of the research consisted of 200 people determined by power analysis. Data were collected by a structured question form and the FINRISK scale. Participants' height, weight, waist circumference were measured by the researcher, and venous fasting blood glucose (FBG) with Glycosylated Hemoglobin (HbA1c) were taken by the researcher. Results: The average age of the participants was 46.93 +/- 14.83 (18-86). It was determined that the vast majority of the individuals participating in the study were female (65%), 63% were married, 50.5% received high school or higher education, and 59% worked in an income-generating job. The findings was indicated that 41.5% of the participants were in the 'high-risk group' for type-2 diabetes according to the FINDRISK score scale. Sensitivity of FINDRISK score to FBG was 100% and specificity was 60%. Conclusion: As a result of findings in this study indicate that It was determined that the risk of DM was high in the first degree relatives of the patients hospitalized with Type-2 DM and the FINDRISK score scale was a good scale in predicting new asymptomatic Type 2 diabetes.
AtıfWoS1OpenAlex1TR Dizin2İncele - MakaleAçık Erişim2021Scopus SJRQ3Erectile dysfunction treatment with Phosphodiesterase-5 Inhibitors: Google trends analysis of last 10 years and COVID-19 pandemic
Deger, Muslim Dogan; Madendere, Serdar
Objectives: We aimed to analyze the trend change of the most popular Phosphodiesterase-5 Inhibitors (PDE5i) over time and geography by using Google Trends (GT) data in 10 years period and COVID-19 pandemic. Materials and methods: GT is able to generate a line-graph, showing how interest has increased or decreased over a period within specific territories. The search values for specific terms are indexed as relative search volume (RSV), which is presented on a scale from 0-100. Avarage annual percentage change (AAPC) and RSV were analyzed to evaluate gain or loss of interest in trends. Search terms were generated for Food and Drug Administration (FDA)-approved PDE5i; tadalafil, sildenafil, vardenafil, avanafil, and their most-used brand names. The data was within worldwide from 1 January 2010, to 31 December 2020, using the global query category. Results: The overall interest in PDE5i has doubled. Sildenafil has become the most trend PDE5i of today with a regular increase (AAPC: 0.016, p < 0.01). Although the search trend of tadalafil remained almost constant until 2014, the rate of increase in the last 6 years raised and tadalafil has become the 2nd most popular PDE5i recently (AAPC: 0.007, p < 0.01). For vardenafil there has been a decreased interest (AAPC: -0.009, p < 0.01). There is no significant change in avanafil trend (AAPC: 0.000, p: 0.5). All PDE5i interest on GT decreased notably from February to June 2020. But after June, search trends reached the level before the COVID-19 period in a month. Conclusions: These findings show us, with its increasing prevalence, erectile dysfunction (ED) has become a major public health problem. People from different geographies search the Internet for ED treatment options. Patients should be informed that ED may be the first sign of many comorbid diseases, and patients with ED should be referred to a health institution for diagnosis and treatment.
AtıfWoS11OpenAlex13İncele - MakaleAçık Erişim2021Relationship between androgen levels and neutrophil/lymphocyte ratio in patients diagnosed with hirsutism
Sayilan, Samet; Mert, Meral; Kulakac, Nursen
Aim: Hirsutism is a disease involving increased terminal hair growth in women with a male-type distribution pattern in androgen-sensitive areas such as the chin, upper lip, chest, abdomen, back, and thighs. Our review of the available literature revealed no previous studies concerning the role of the peripheral blood neutrophil/lymphocyte ratio (NLR), an easily calculated and noninvasive marker, in hirsutism. The purpose of this research was to determine the relationship between androgen levels and NLR in female patients diagnosed with hirsutism. Material and Methods: The files of 392 patients presenting to the Bakirkoy Dr. Sadi Konuk Education and Research Hospital due to hirsutism between 2018 and 2020 were included in this cross-sectional, retrospective study. Patients' hirsutism and menstrual cycles, age at menarche, number of pregnancies in the case of married women, number of living children, and history of infertility were investigated. Hyperandrogenemia findings, such as hair loss and acne, were also recorded. Patients' biochemical and complete blood count parameters were evaluated. Results: The mean age of the participants was 26.27 +/- 6.37 years (min-max: 16-48), and their androgen levels were statistically significantly associated with high-density lipoprotein, hemoglobin, hematocrit, 17-hydroxyprogesterone, and HbA1c levels (p<0.05). However, no significant relationship was found between patients' androgen levels and NLR values (p>0.05). Discussion: No significant relationship was determined in this study between androgen levels and NLR values in women diagnosed with hirsutism. Due to the limited numbers of previous similar studies, further research with larger patient numbers is now needed.
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