Yazarlar
- Uzun, Sevda(79)
- Kulakaç, Nurşen(40)
- Turan, Ibrahim(33)
- Demir, Selim(32)
- Türkkan, Tuğba(24)
- Aydin, Aydanur(23)
- Topal, Fevzi(22)
- Aliyazicioglu, Yuksel(21)
- Tuncer, Metin(21)
- Bayrakdaroglu, Serdar(19)
- Demirağ, Hatice(19)
- Hintistan, Sevilay(18)
- Topal, Meryem(18)
- Yılmaz, Coşkun(18)
- Bayrakdaroğlu, Serdar(15)
- Yilmaz, Coskun(15)
- Mentese, Ahmet(14)
- Reis, Hatice Catal(14)
- Demir Doğan, Melike(13)
- Emirza, Elif Güzide(13)
- Memetoglu, Mehmet Erdem(13)
- Tuncer, Gülsüm Zekiye(13)
- Bülbül, Kenan(12)
- Cin, Aynur(12)
- Düzgün, Azer Özad(12)
- Koçak, Tevfik(12)
- Odaci, Hatice(12)
- Oğuzhan, Hatice(12)
- Tonkaz, Duygu Erkal(12)
- Tonkaz, Mehmet(12)
- Turk, Veysel(12)
- Ceylan, Halil Ibrahim(11)
- Kilinc, Kagan(11)
- Köse, Aslı(11)
- Merdan, Mehmet(11)
- Acet, Tuba(10)
- Aksoy, Bahar(10)
- Aydin Sayilan, Aylin(10)
- Baltaci, Cemalettin(10)
- Deger, Orhan(10)
Yayınlar
- MakaleAçık Erişim2025Scopus SJRQ1Investigation of perceived parental attitude in children exposed to sexual abuse: A case-control study
Bayrak, Nurten Gülsüm; Emirza, Elif Güzide; Uzun, Sevda
Background: The enduring impact of children being subjected to sexual abuse is characterized by lasting traumatic effects. Aims: This study aims to assess the influence of perceived parental attitudes on the incidence of sexual abuse in children who have experienced such abuse, comparing them with a control group. Methods: The research took place at the Child Advocacy Center (CAC) of a hospital in northern Turkey and in the pediatric outpatient clinics of the same institution. The study evaluated 101 children who were exposed to sexual abuse and 100 children who were not. Data collection took place between November 2022 and August 2023. The study employed a ‘Descriptive Information Form’ and the ‘Parental Attitude Scale’ for both case and control groups. The t-test for independent samples, descriptive statistics, and logistic regression analysis were used for data analysis. Results: Analysis of scores from the Parental Attitude Scale revealed significantly lower mean scores in acceptance-involvement and strictness-supervision in the case group (p <.05). The mean scores for ‘acceptance-involvement’ (X¯ = 22.82 ± 6.26, X¯ = 25.71 ± 3.89) were highest in the case and control groups. Neglectful attitude (38.6%) was more prevalent in the case group, while the control group exhibited a higher frequency of democratic attitude (37%). In terms of predictors, acceptance-involvement (OR = 1.091, p =.005) and maternal employment (OR = 4.410, p <.001) were identified as the most significant predictors of exposed to sexual abuse. The study’s Cronbach’s alpha value for the scale was α =.743. Conclusion: The study’s findings on parental attitudes suggest a potential connection between children’s exposure to sexual abuse and inadequate parental acceptance, involvement, supervision, and control.
- MakaleAçık Erişim2025Scopus SJRQ1An Examination of Relationships Between Postural Habits and Awareness of Fatigue and Musculoskeletal Discomfort in Nurses
Tuncer, Metin; Tuncer, Gülsüm Zekiye; Turan, Şeyma; Khorshtd, Leyla
Introduction: Prolonged fatigue, caused by the hospital's demanding workload and physical demands, can increase strain on the musculoskeletal system, leading to musculoskeletal issues that may negatively impact nurses' job performance and quality of life. High postural awareness, on the other hand, can help nurses develop correct posture and movement habits, reducing the risk of experiencing discomfort, thus preserving their physical health and supporting workforce sustainability. Therefore, it is of particular importance to determine the relationship of postural awareness to fatigue and musculoskeletal discomfort in nurses working in a hospital environment with heavy working conditions and many ergonomic risks. Aim: The aim of this study was to describe the postural habits, awareness, occupational fatigue levels and musculoskeletal disorders of nurses working in hospitals and to examine the relationships between these factors. Method: This study used a quantitative cross-sectional design. The study sample consisted of 132 nurses working in a hospital in Türkiye. The data for the study were collected between July and October 2023 using the Occupational Fatigue Exhaustion/Recovery Scale (OFER), Cornell Musculoskeletal Discomfort Questionnaire (CMDQ) and Postural Habits and Awareness Scale (PHAS). Results: A significant positive, low-level correlation was found between the Recovery subscale of the OFER scale and the Postural Habits subscale of the PHAS scale (r = 0.277, p < 0.05). A significant negative, moderate-level correlation was observed between the Chronic Fatigue subscale of the OFER scale and the Postural Habits subscale of the PHAS scale (r = −0.311, p < 0.001). Additionally, a significant negative, moderate-level correlation was found between the Acute Fatigue subscale of the OFER scale and the Postural Habits subscale of the PHAS scale (r = −0.326, p < 0.001). Conclusion: This study found that as nurses' correct postural habits improved, both acute and chronic fatigue decreased, whereas recovery increased. It is suggested that interventions aimed at enhancing postural awareness and promoting correct postural habits in nurses may also positively influence occupational fatigue and exhaustion.
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İncele - MakaleYalnız künye2025Scopus SJRQ2“I Am Learning to Protect Myself with Mika”: An Evaluation of Self-Protection Behaviors of Turkish Preschoolers
Yılmaz Irmak, Türkan; Kızıltepe, Rukiye; Eslek, Duygu; Kütük, Bahtım; Güney, Onuray
Child sexual abuse (CSA) prevention programs contribute to increases in children’s knowledge and skills to protect themselves from CSA. However, there is a paucity of research investigating self-protection behaviors among children to demonstrate whether relevant CSA knowledge and skills are transferable in risky situations. We aimed to examine the effectiveness of the “I am learning to protect myself with Mika” program on preschool children’s self-protection behaviors. The sample included 51 preschool children (54.9% girls) from Izmir, Turkey and their parents. The mean age of the children was 65.57 months (SD = 7.21). The present study employed a posttest-only control group design, and the classrooms were randomly assigned to the intervention and wait-list comparison groups. The participating teachers implemented the program over a five-week period. Then, children’s self-protection behavior was assessed with children from both groups using a role-play scenario involving a request from a stranger. Accordingly, we tested whether children in the intervention group were more likely to demonstrate self-protection behaviors compared to those in the comparison group. The findings showed that the intervention group (77.3%) rejected the offer from strangers and behaved more safely than did the wait-list comparison group (24.2%; χ2(1) = 13.879, p < 0.001). “I am learning to protect myself with Mika” was found to be effective in contributing to preschoolers’ self-protective behaviors. The promising results obtained in this study may encourage further exploration of the behavioral outcomes of sexual abuse prevention programs.
- MakaleAçık Erişim2025Scopus SJRQ1Development and psychometric evaluation of the father-preterm infant bonding scale
Gül, Uğur; EFE, Emine; Bektaş, Murat
Objective: The purpose of this study is to describe the development process of the Father-Preterm Infant Bonding Scale (F-PIBS) and to report the results of its psychometric evaluation. Methods: A methodological, correlational, comparative, and cross-sectional design was employed. The study was conducted between June 2023 and September 2024 and included 182 fathers with preterm infants hospitalized in the Neonatal Intensive Care Unit (NICU). Exploratory and confirmatory factor analyses were performed to evaluate the reliability of the scale, and validity was tested using Cronbach's alpha reliability coefficient, split-half reliability, item-total correlations, and Hotelling's T-squared test. Results: The scale comprises 10 items distributed across two sub-dimensions. The content validity ratios of the scale items ranged from 0.80 to 1.00. Cronbach's alpha values for the total scale and sub-dimensions were 0.878, 0.796, and 0.845, respectively. Conclusion: F-PIBS is reliable, valid, and appropriate for evaluating father-preterm newborn bonding levels in the NICU.
AtıfScopus4WoS3OpenAlex3İncele - MakaleAçık Erişim2025Scopus SJRQ1Psychosocial problems experienced by intensive care nurses regarding sleep pattern within the scope of working conditions: A phenomenological study
Atasayar, Belgin Şen; Emirza, Elif Güzide; Uzun, Sevda
Background: Nurses working in intensive care units experience insomnia and accompanying psychosocial problems due to working conditions. Aim: This study explores with a phenomenological approach the psychosocial problems experienced by intensive care nurses regarding sleep patterns within the scope of working conditions. Study Design: In this phenomenological study, semi-structured in-depth interviews were conducted with 16 nurses working in the surgical intensive care unit of a state hospital in Türkiye. Criterion sampling method, one of the purposive sampling methods, was used to reach the sample group. Researchers' interviews continued until they reached data saturation. All interviews were recorded on a voice recorder after obtaining the necessary permissions from the nurses and then transcribed. The study data were evaluated using thematic analysis. The current manuscript was reported following the COREQ checklist. Results: Data analysis revealed three main themes (how working as an intensive care nurse changes sleep patterns, the relationship between shift work, work performance, patient care and how working as an intensive care nurse changes individual life and coping strategies) and nine subthemes (mental, physical, social, work performance, patient care, nutrition, family life, social life and coping). Conclusion: The study's findings revealed that nurses working in intensive care experienced psychosocial difficulties related to sleep patterns and had trouble coping. In particular, it was determined that sleep problems of intensive care nurses cause difficulties in family life, nutrition and social life. It is recommended that the number of personnel in workplaces be increased, overtime hours should be limited, and professional development and training on the importance of sleep for all nurses should be provided. Relevance to Clinical Practice: Nurses working in intensive care units may experience psychosocial problems due to working conditions, which may negatively change their coping skills. Therefore, organizing the working conditions of nurses positively changes their coping skills.
AtıfScopus6WoS6OpenAlex6İncele - MakaleAçık Erişim2025Scopus SJRQ2Investigation of Nonstandard Finite Difference for Fractional Order Covid-19 Model
Merdan, Mehmet; Acikgoz, Pınar
This article examines a mathematical model of the Covid-19 type. We demonstrate how the population is impacted by immigration, protection, the mortality, exposure, curing, and interactions between sick and healthy individuals. There are five classifications in our model: exposed, susceptible, infected, quarantined, and recovered. The model is subjected to numerical and fractional analysis in this instance. The numerical analysis is performed using the fractional order non-standard finite difference (NSFD) scheme. The Grunwald-Letnikov numerical approximation technique is used for fractional analysis. The findings are evaluated by simulations using the Matlab tool.
AtıfScopus3WoS2OpenAlex2
İncele - MakaleYalnız künye2025Scopus SJRQ3Factors Affecting Separation Anxiety Disorder in Adolescent Earthquake Survivors: The Case of Kahramanmaraş Earthquakes (2023)
Kiymis, Ibrahim; Dogan, Ahsen Aydin
Objective The Kahramanmaras Earthquakes (2023) are the largest and most devastating earthquakes in the history of the Republic. The effects of these earthquakes are particularly deeply felt among younger generations and trigger various psychological factors. Therefore, the aim of this study is to measure the levels of post-traumatic stress disorder (PTSD), social phobia (SP), generalized anxiety disorder (GAD), and depression on separation anxiety disorder (SAD) among adolescent earthquake survivors affected by the Kahramanmaras Earthquakes (2023). Methods In the study, the data were obtained using a survey method. A total of 605 adolescent earthquake survivors exposed to the Kahramanmaras earthquakes were reached. The research was analyzed using structural equation modeling (SEM). Results Surprisingly, according to the research findings, there was no significant and positive relationship between SP (β = -0.006, P > 0.05) and Depression (β = -0.117, P > 0.05) on SAD. Conclusions Consequently, while PTSD and GAD had significant and positive effects on SAD in those adolescent earthquake survivors affected by the Kahramanmaras Earthquakes (2023), SP and Depression did not have significant and positive effects on SAD. Therefore, it is recommended that future studies examine the effects of SP and Depression on SAD more comprehensively and in detail through qualitative research.
AtıfOpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ2The biological activity and phenolic content of endemic Astragalus baibutensis
Ozcan, Kadriye; Acet, Tuba; Yiğittürk, Gürkan
Astragalus baibutensis, is a plant endemic to Turkey, belonging to Fabaceae family, that is used as a folk medicine and food in this country. The purpose of this study is to find out the biological activities such as antioxidant, antimicrobial, enzyme inhibitory and DNA protective activity and also analyse the phenolic contents of the plant. To determine of antioxidant activity ABTS and DPPH assays were performed. Disc diffusion and microdilution methods were used to evaluate the antimicrobial activity. Additionally, enzyme inhibitory activities such as α-amylase, α-glucosidase, and tyrosinase were determined by using spectrophotometric methods. DNA protective activity was detected using pUC19 Plazmid DNA. The antiproliferative effect on SKOV-3 human ovarian cancer cells was examined by WST-8 assay. In addition, the phenolic contents were analysed by using HPLC. The biological activity of ethyl acetate extract of the root was found to be higher than those of other extracts. This extract had the highest amount of apigenin as phenolic compound. On the other hand, extracts showed moderate inhibition against the tested microorganism and antiproliferative properties in a concentration-dependent manner toward ovarian cancer cells. According to the results, Astragalus baibutensis has the potential for pharmaceutical and food additive usage.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ1Patients' Experiences With Complementary and Alternative Treatments to Manage Chemotherapy Symptoms: A Phenomenological Study
Özmaya, Esma; Uzun, Sevda
This phenomenological study aims to explore the experiences of individuals undergoing chemotherapy, focusing on their symptoms and the use of complementary and alternative treatments to cope with these challenges. Thirteen individuals diagnosed with cancer in a city in the central region of Turkey were interviewed using a semi-structured, in-depth approach in this phenomenological study. The criterion sampling method was employed to select participants, and interviews continued until data saturation was achieved. Thematic analysis was applied to the audio-recorded and transcribed interviews. The study adhered to the COREQ checklist for reporting qualitative research. The data analysis revealed 2 main categories (effects of cancer and chemotherapy on individuals, the use of complementary and alternative treatments to cope with the symptoms of patients receiving chemotherapy) and 6 themes (psychological effects, social impacts, physical effects, social practices, psychological practices, and physical practices). The study demonstrated that individuals faced significant psychological, physical, and social challenges due to cancer, posing difficulties in coping. The symptoms had a substantial negative impact on individuals. The research identified the use of various alternative methods, such as yoga, the Mediterranean diet, and music therapy, as coping strategies. It is recommended that individuals undergoing chemotherapy explore complementary and alternative treatment methods to effectively manage symptoms.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ3Comparison of drop table and diversified chiropractic techniques in patients with non-specific neck pain; [Comparação das técnicas quiropráticas drop table e diversified em pacientes com dor cervical inespecífica]
Kızıltoprak, Dünya Tajik; Hatıp, Sefa Haktan; Kızıl, Ömer Dicle; Aydın, Emine Büşra
Introduction: Neck pain is a common musculoskeletal disorder associated with pain, reduced cervical mobility, and decreased muscle strength, often leading to functional limitations. Chiropractic manipulation is widely used as a conservative treatment, yet the comparative effects of different techniques remain unclear. ## Objective To compare the effects of the diversified and drop table chiropractic techniques on pain, cervical range of motion, and muscle strength in individuals with non-specific neck pain. ## Methods This randomized controlled clinical trial included 45 participants with non-specific neck pain, randomly assigned to three groups: diversified (DG; n = 15), drop table (DTG; n = 15), and control (CG; n = 15). Interventions were applied twice weekly for four weeks. The primary outcome measure was pain level assessed using the McGill Pain Questionnaire. Secondary outcome measures were cervical joint range of motion assessed with a goniometer and isometric neck muscle strength assessed using a microFET2 dynamometer. Outcomes were assessed pre- and post-intervention. ## Results Both DG and DTG demonstrated significant increases in cervical range of motion compared with the CG. Pain levels significantly decreased in both intervention groups. DG showed significant improvements across all isometric muscle strength measures, while DTG demonstrated selective improvements in flexion and right lateral flexion. CG showed no significant changes, except a decrease in extensor strength. ## Conclusion Chiropractic interventions effectively reduce pain and enhance cervical function in individuals with non-specific neck pain. The diversified technique provided broader muscle strength improvements, while the drop table technique showed more selective effects, emphasizing the need for individualized technique selection in clinical practice. Open access and CC-BY licensed.
- MakaleAçık Erişim2025Scopus SJRQ1Evaluation of Antioxidant and Enzyme Inhibition Properties of Siran Propolis: Correlations With Phenolic Content Determined by LC–MS/MS
Balci, Neslihan; Aslan, Kubra; Erturk, Adem; Gulcin, Ilhami
This study evaluates the antioxidant activity, enzyme inhibition potential, and phenolic composition of ethanolic Siran propolis extract. Antioxidant capacity was measured using reducing power (CUPRAC, FRAP, and Fe3+-reducing) and radical scavenging (DPPH·, ABTS·+, and DMPD·+) assays. The extract showed strong reducing ability, surpassing standard antioxidants in CUPRAC and FRAP assays, correlating with high ferulic acid (40.40 mg/g) and p-coumaric acid (88.60 mg/g) levels identified by LC–MS/MS. While it demonstrated notable DPPH· scavenging (IC50: 30.14 μg/mL), ABTS·+ activity was weaker (IC50: 272.44 μg/mL). Enzyme inhibition assays indicated effective inhibition of α-glycosidase, AChE (IC50: 2.15 μg/mL), hCA I, and hCA II. Notably, AChE inhibition was stronger than the standard tacrine inhibitor (IC50: 8.82 μg/mL), suggesting neuroprotective potential. The observed bioactivities are attributed to synergistic effects of phenolic acids and flavonoids, including quercetin, luteolin, taxifolin, and resveratrol. These findings highlight Siran propolis as a promising natural antioxidant and enzyme inhibitor source with potential therapeutic applications and food formulations.
AtıfScopus12WoS12OpenAlex11İncele - MakaleAçık Erişim2025Scopus SJRQ2Volumetric and microstructural changes in the Hippocampus and cingulum in children with west syndrome
PALANCI, Özgür; KAMAŞAK, Tülay; AYDIN KASAP, Zeliha; EYÜBOĞLU, İlker; DİLBER, Beril; CANSU, Ali
Purpose: We aimed to investigate structural changes in the hippocampus using automated segmentation techniques to evaluate the anatomy and function of the hippocampus in patients with West syndrome (WS). Methods: The study included 48 participants (24 with WS and 24 healthy controls) aged 0‐4 years. Automated segmentation methods were used to measure hippocampal volume and evaluate diffusion tensor imaging (DTI) parameters such as fractional anisotropy (FA) and mean diffusivity (MD). Bonferroni correction was applied for multiple comparisons, setting the adjusted significance threshold at p < 0.0033. Results: Children with WS exhibited significantly reduced total hippocampal volume and diminished volumes in the CA2–CA3, CA4-dentate gyrus (CA4-DG), and SR-SL-SM regions compared to healthy controls (padj <0.0033). After correction, no significant differences were found in the CA1 and subiculum regions (padj >0.0033). Although initial comparisons between ongoing WS and seizure-controlled WS suggested increased volumes in several hippocampal regions in the seizure-controlled group, these differences did not remain significant after adjustment and must be interpreted with caution. Notably, patients with seizure-controlled WS displayed larger hippocampal volumes, higher FA, and lower MD values, indicating a possible link between seizure activity and structural alterations. Additionally, DTI analysis of the cingulum revealed lower FA and higher MD values in WS patients, suggesting compromised microstructural integrity. Conclusions: These findings emphasize the potential role of hippocampal alterations in the pathophysiology of WS and suggest that DTI parameters may serve as useful measures for monitoring disease progression and treatment response.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2025Scopus SJRQ2Parents’ experiences on the management of the process after sexual abuse of their children in northern region of Turkey: Qualitative study
Bayrak, Nurten G.; Uzun, Sevda
Background: Child abuse is a universal problem with medical, legal, and psychosocial dimensions that every child is at risk of encountering all over the world. Aim: The aim of this study was to evaluate the experiences of parents regarding the management of the process after sexual abuse of their children using a qualitative approach. Methods: In this qualitative study, semi-structured in-depth interviews were conducted with the parents of 15 children who were exposed to qualified sexual abuse living in a city in Northern Turkey. Criterion sampling method, one of the purposive sampling methods, was used to reach the sample group. Interviews continued until data saturation was achieved. All interviews were audio recorded and then transcribed. The data of the study were evaluated using thematic analysis. The study was conducted and reported according to the consolidated criteria for reporting qualitative research (COREQ) checklist. Results: In the analysis of the data, three themes (effects of child sexual abuse on the family, sexual abuse and process management, and attitudes and approaches to the child after sexual abuse), and nine sub-themes (mental, physical, social, reactions, difficulties experienced, coping, cognitive dimension, emotional dimension, behavioral dimension) were identified. Conclusion: As a result of the study, it was determined that parents were negatively affected psychologically by the sexual abuse of their children. This study reveals that the concept of family is very important in all aspects of the sexual abuse of children. As a result of the study, it was determined that families were not very effective in process management and some parents blamed themselves for the incident they experienced.
AtıfScopus1WoS2OpenAlex2İncele - MakaleYalnız künye2025Scopus SJRQ2First evaluation and ecological risk of potentially toxic elements in the formations of Akçakale cave (Gümüşhane-NE-Türkiye)
Saydam Eker, Çiğdem; Külekçi, Gökhan; Uçak, Gül
In this study, the potential toxic element levels (PTEs) and adverse health effects of Akçakale cave formations were evaluated using geochemical parameters such as enrichment factor (EF), geo-accumulation index (Igeo), contamination factor (CF), ecological risk factor (Eri), potential ecological risk index (PERI), and non-carcinogenic hazard index (HI). Water does not pose a pollution risk, as the concentrations of potentially toxic elements in all samples are within the permissible limits for drinking water. According to the calculated geochemical parameters, all the samples were polluted with As, Co, Ni, Cu, V, and Pb. Ni, As, Cu, and Pb show very high ecological risk (PER > 320) in all samples, except Cu and Pb in T2T. The PERI values of the PTEs were more than 600 in all samples, indicating a very high potential ecological risk. The HI > 1 values for Co and As in all samples for both adults and children suggested potential non-carcinogenic health risks from exposure to these elements in the cave environment. The PTEs in the Akçakale cave formation were most likely linked to lithogenic, geogenic (Pb–Zn-Cu mineralization), and anthropogenic (agricultural activities) processes, per the findings of the data analysis using multivariate statistics (PCA and PCC). These data obtained are the first findings regarding the potential toxic element content of Akçakale cave.
AtıfScopus2WoS2OpenAlex3İncele - MakaleAçık Erişim2025Scopus SJRQ1A multi-stage fusion deep learning framework merging local patterns with attention-driven contextual dependencies for cancer detection
Catal Reis, Hatice; Turk, Veysel
Cancer is a severe threat to public health. Early diagnosis of disease is critical, but the lack of experts in this field, the personal assessment process, the clinical workload, and the high level of similarity in disease classes make it difficult. In recent years, deep learning-based artificial intelligence models have shown promise, with the potential to increase diagnosis speed and accuracy. These models attract attention with their automatic learning and adaptation capabilities. In this study, the deep learning-based PADBSRNet model and the PADBSRNet-Vision Transformer (ViT) hybrid method are proposed for the detection of brain tumors and skin and lung cancers. PADBSRNet is a comprehensive deep neural network architecture that integrates separable and traditional convolution layers, multiple attention mechanisms, bidirectional recurrent neural networks, and cross-connections/multi-stage feature fusion strategies. This architecture offers significant advantages in terms of effectively extracting local-global, contextual features and accurately modeling long-term dependencies in image classification tasks. The second proposed approach developed a hybrid method that combines the advantages of the PADBSRNet model and the ViT model. Experimental analysis on medical datasets such as the Figshare Brain Tumor Dataset, IQ-OTH/NCCD Dataset, and Skin Cancer: Malignant vs. Benign Dataset has evaluated the proposed models' performances. According to the experimental results, the PADBSRNet model has shown successful performance with 95.24 %, 99.55 %, and 88.61 % accuracy rates, respectively. The experimental findings show that the proposed deep learning model can effectively learn the complex relationships and hidden patterns of cancer disease, thus producing applicable and effective results in cancer diagnosis.
AtıfScopus3OpenAlex2İncele - MakaleAçık Erişim2025Scopus SJRQ1Protective effect of tarantula cubensis extract on ischemia-reperfusion injury in rat ovaries: Immunohistochemical, biochemical and histopathological evaluations
Paksoy, Zahid; Ozturk Sarikaya, Sevim Beyza; Yumusak, Nihat
Ischemia-reperfusion (IR) injury is a common pathology affecting the ovary. This study aimed to investigate the effect of Tarantula cubensis extract (TCE) on ovarian IR injury. Forty-two female rats were used and randomly divided into 7 groups: Control, Sham, IR, Ischemia+TCE+Reperfusion, TCE+IR, Ischemia+Ethanol+Reperfusion and Ethanol+IR. The control and sham groups did not receive any treatment. All other groups were subjected to 3 h of ischemia + 3 h of reperfusion. A single dose of TCE (0.2 ml Theranekron) was administered subcutaneously either before or after ischemia in the treatment groups. In the last 2 groups, ethanol was applied before or after ischemia. After reperfusion, blood samples were collected and analyzed for biochemical parameters. Additionally, the ovarian tissue was evaluated histopathologically and immunohistochemically. The IR group exhibited more marked hyperemia, hemorrhage, and necrosis. Both treatment groups showed histopathological improvement. Moreover, the recovery rate was greater in the animals given theranekron before ischemia. IR injury caused oxidative stress in the rats. However, Theranekron did not significantly reduce the MDA levels (p > 0.05). On the other hand, SOD levels were significantly increased in the treatment groups (p < 0.01). Compared to the control and sham groups, the IL-1β, IL-6 and TNF-α levels were very high in the IR group. Conversely, the immunoreactivity of these cytokines was further reduced in the animals given theranekron before ischemia. Our findings suggest that TCE may be beneficial in the treatment of ovarian IR damage, especially when Theranekron is given before ischemia.
AtıfScopus3WoS3OpenAlex3İncele - MakaleYalnız künye2025Scopus SJRQ1ChatGPT-4 in Nursing Research: A Methodological Evaluation of Bias Risk in Randomized Controlled Trials
Tuncer, Metin; Tuncer, Gülsüm Zekiye
Background: Conducting bias assessments in systematic reviews is a time-consuming process that involves subjective judgments. The use of artificial intelligence (AI) technologies to perform these assessments can potentially save time and enhance consistency. Nevertheless, the efficacy of AI technologies in conducting bias assessments remains inadequately explored. Aim: This study aims to evaluate the efficacy of ChatGPT-4o in assessing bias using the revised Cochrane RoB2 tool, focusing on randomized controlled trials in nursing. Methods: ChatGPT-4o was provided with the RoB2 assessment guide in the form of a PDF document and instructed to perform bias assessments for the 80 open-access RCTs included in the study. The results of the bias assessments conducted by ChatGPT-4o for each domain were then compared with those of the meta-analysis authors using Cohen's weighted kappa analysis. Results: Weighted Cohen's kappa values showed better agreement in bias in the measurement of the outcome (D4, 0.22) and bias arising from the randomization process (D1, 0.20), while negative values in bias due to missing outcome data (D3, −0.12) and bias in the selection of the reported result (D5, −0.09) indicated poor agreement. The highest accuracy was observed in D5 (0.81), and the lowest in D1 (0.60). F1 scores were highest in bias due to deviations from intended interventions (D2, 0.74) and lowest in D3 (0.00) and D5 (0.00). Specificity was higher in D5 (0.93) and D3 (0.82), while sensitivity and precision were low in these domains. Conclusions: The agreement between ChatGPT-4o and the meta-analysis studies in the same RCT assessments is generally low. This indicates that ChatGPT-4o requires substantial enhancements before it can be used as a reliable tool for bias risk assessments. Clinical Relevance: The AI–based tools have the potential to expedite bias assessment in systematic reviews. However, this study demonstrates that ChatGPT-4o, in its current form, lacks sufficient consistency, indicating that such tools should be integrated cautiously and used under continuous human oversight, particularly in evidence-based evaluations that inform clinical decision-making.
AtıfScopus1İncele - MakaleAçık Erişim2025Scopus SJRQ3Chemical composition of essential oils and comparative analysis of enzyme inhibitory, antioxidant and antimicrobial activities in essential oils of endemic Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N. Kilian
Fidan, Muhammed Said; Baltacı, Cemalettin; Akmeşe, Osman; Sefalı, Abdurrahman; Aygül, İmdat; Öz, Mehmet
In this study, essential oil from the aerial parts of Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N. Kilian was extracted via hydrodistillation using a Clevenger apparatus. GC-MS/FID analysis determined aldehydes (28.31%) as the dominant group, with eucalyptol (8.71%) as the main constituent. Antioxidant activities were exhibited using DPPH, ABTS, and FRAP assays, with the essential oil demonstrating relatively higher antioxidant properties. The essential oil also showed higher levels of bioactive components, including total antioxidant capacity (160.26 mg AA eq./100 mL), total phenolic content (21.57 mg GA eq./100 mL), and total flavonoid content (14.85 mg QE eq./100 mL). While G. sericea essential oil demonstrated some antioxidant activity, it was significantly lower compared to the reference standard ascorbic acid (AA). The antimicrobial results showed relatively higher antimicrobial activity compared to most bacterial and fungal strains, as evidenced by lower MIC and MBC values and larger inhibition zones. Nevertheless, chloramphenicol (CH) and nalidixic acid (NA) continually showed superior antimicrobial efficacy, with the lowest MIC and MBC values and the largest inhibition zones. The essential oil also demonstrated potent enzyme inhibitory activity, especially against CA-II, AChE, and BChE, with the lowest IC50 value observed for CA-II, highlighting its potential as a potent enzyme inhibitor. However, the essential oil exhibited comparatively greater inhibition against AChE, BChE and α-amylase but was less effective overall. These findings suggest that the G. sericea essential oil has important antioxidant potential and enzyme inhibitory activity, while the essential oil shows varying efficacy across different enzymes.
- MakaleAçık Erişim2025Scopus SJRQ1The evaluation of the mediation role of life engagement in resilience and trauma levels of individuals experiencing the earthquake in Kahramanmaraş, Türkiye
Özmaya, Esma; Erkoç, Beyza; Kalaycı, Sami; Uzun, Sevda; Lotfi, Sayra
The aim of this study is to evaluate the mediation role of life engagement in resilience and trauma levels of individuals experiencing the earthquake on February 6, 2023 in the city of Kahramanmaraş in Türkiye. The sample of this descriptive and correlational study included 1406 individuals. The questionnaire data was obtained through Google Forms and other data collection tools were Socio-demographic Information Form, Trauma Level Determination Scale, Short Resilience Scale and Life Engagement Scale. To analyse the data, frequency (percentage, arithmetic mean) and correlation analyses were used. Depending on the findings of the study, the resilience and trauma levels were negatively correlated, whereas the resilience and life engagement levels were positively correlated. Furthermore, the life engagement levels were negatively correlated with trauma levels while they were positively correlated with resilience. It was found that the life engagement played an mediation role in resilience and trauma levels of individuals experiencing the earthquake in Kahramanmaraş, Türkiye. In this study, we found that the life engagement has an important role in resilience and trauma levels of individuals. We are of the opinion that the findings of this study might help researchers and conductors to plan and perform effective strategies for post-impact phase of an earthquake.
AtıfScopus1WoS1OpenAlex1İncele - MakaleYalnız künye2025Scopus SJRQ2Hand grip strength in young adults: association with obesity-related anthropometric variables
Doğan, Gökcen; Tokaç Er, Nida; Öztürk, Meryem Elif; Meriç, Çağdaş Salih; Yilmaz, Hacı Ömer; Yabanci Ayhan, Nurcan
Aim: The aims of this study were to evaluate hand grip strength in young adults, to examine its relationship with anthropometric values, and to determine which values are predictive. Subject and methods: This prospective, cross-sectional study was conducted with 913 healthy young adults aged 18–30 years. A questionnaire form was administered in face-to-face interviews, and anthropometric measurements including height, body weight, waist circumference (WC), hip circumference (HC), mid-upper arm circumference (MAC), neck circumference (NC), triceps skinfold thickness (TSF), and hand grip strength (kg) were performed for each participant. Results: Hand grip strength was significantly higher for men than for women (p < 0.001), and was also higher in obese and overweight people compared to underweight participants (p < 0.001). Hand grip strength was correlated with weight, height, body mass index, MAC, TSF, WC, and NC (p < 0.001). The predictive ability of anthropometric measurements in estimating hand grip strength was thus demonstrated in a large population of healthy young adults. Significant regression was found, with an R2 value of 0.556. Hand grip strength increased by 0.282 kg for each centimeter of height and by 0.135 kg for each centimeter of MAC. The hand grip strength of male participants was 0.424 kg greater than that of females. Height, MAC, TSF, and sex were significant predictors of hand grip strength. Conclusion: According to our results, variability in hand grip strength among healthy subjects can be explained by height, MAC, TSF, WC, HC, age, and sex. The estimation of hand grip strength could be established based on these demographic and anthropometric variables.
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