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- Uzun, Sevda(79)
- Kulakaç, Nurşen(40)
- Turan, Ibrahim(33)
- Demir, Selim(32)
- Türkkan, Tuğba(24)
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- Hintistan, Sevilay(18)
- Topal, Meryem(18)
- Yılmaz, Coşkun(18)
- Bayrakdaroğlu, Serdar(15)
- Yilmaz, Coskun(15)
- Mentese, Ahmet(14)
- Reis, Hatice Catal(14)
- Demir Doğan, Melike(13)
- Emirza, Elif Güzide(13)
- Memetoglu, Mehmet Erdem(13)
- Tuncer, Gülsüm Zekiye(13)
- Bülbül, Kenan(12)
- Cin, Aynur(12)
- Düzgün, Azer Özad(12)
- Koçak, Tevfik(12)
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- Tonkaz, Duygu Erkal(12)
- Tonkaz, Mehmet(12)
- Turk, Veysel(12)
- Ceylan, Halil Ibrahim(11)
- Kilinc, Kagan(11)
- Köse, Aslı(11)
- Merdan, Mehmet(11)
- Acet, Tuba(10)
- Aksoy, Bahar(10)
- Aydin Sayilan, Aylin(10)
- Baltaci, Cemalettin(10)
- Deger, Orhan(10)
Yayınlar
- MakaleAçık Erişim2025Inhibition Effect of Diosmin Flavanoid on Some Metabolic Enzymes and Investigation of Antioxidant Properties
Balci, Neslihan
Diosmin is a natural flavonoid obtained by dehydrating flavanone glycoside hesperidin. This study evaluated the inhibition effects of diosmin flavonoid on human carbonic anhydrases (hCA I and hCA II) and acetylcholinesterase (AChE) enzymes, which are linked to various health issues, and compared the results with standard drugs. The antioxidant potential was assessed using five assays, namely DPPH, ABTS, FRAP, CUPRAC and Fe3+ reducing assays. The results determined that diosmin didn’t exhibit strong antioxidant activity. Additionally, the inhibition effects of diosmin on hCA I, hCA II, and AChE enzymes were examined. It effectively inhibited hCA I and hCA II enzymes with Ki values of 3.84±0.63 nM and 15.64±1.90 nM, respectively (Table 1). For comparison, the Ki values of the standard drug AZA were 1.44 ± 0.32 nM for hCA I and 3.66 ± 0.25 nM for hCA II. On the other hand, diosmin effectively inhibited AChE enzymes with Ki values of 9.31±2.40 nM. The Ki values of the standard drug Tacrine was 6.22±1.95 nM for AChE. These findings suggest that diosmin may serve as a selective enzyme inhibitor, particularly for hCA I, but has limited antioxidant capacity. Diosmin exhibited relatively weak antioxidant activity compared to standard antioxidants.
- MakaleAçık Erişim2025Scopus SJRQ2A Safe and Efficient Brain–Computer Interface Using Moving Object Trajectories and LED-Controlled Activation
Aydin, Sefa; Melek, Mesut; Gökrem, Levent
Nowadays, brain–computer interface (BCI) systems are frequently used to connect individuals who have lost their mobility with the outside world. These BCI systems enable individuals to control external devices using brain signals. However, these systems have certain disadvantages for users. This paper proposes a novel approach to minimize the disadvantages of visual stimuli on the eye health of system users in BCI systems employing visual evoked potential (VEP) and P300 methods. The approach employs moving objects with different trajectories instead of visual stimuli. It uses a light-emitting diode (LED) with a frequency of 7 Hz as a condition for the BCI system to be active. The LED is assigned to the system to prevent it from being triggered by any involuntary or independent eye movements of the user. Thus, the system user will be able to use a safe BCI system with a single visual stimulus that blinks on the side without needing to focus on any visual stimulus through moving balls. Data were recorded in two phases: when the LED was on and when the LED was off. The recorded data were processed using a Butterworth filter and the power spectral density (PSD) method. In the first classification phase, which was performed for the system to detect the LED in the background, the highest accuracy rate of 99.57% was achieved with the random forest (RF) classification algorithm. In the second classification phase, which involves classifying moving objects within the proposed approach, the highest accuracy rate of 97.89% and an information transfer rate (ITR) value of 36.75 (bits/min) were achieved using the RF classifier.
AtıfScopus4WoS5OpenAlex3
İncele - MakaleYalnız künye2025Scopus SJRQ2Disease Burden and Sexual Life in Patients with Fibromyalgia: A Phenomenological Study
Demir Çam, Sevgi; Uzun, Sevda; Koyunoğlu, Bedriye Cansu
The aim of this study was to evaluate the burden of disease and sexual life experiences in patients with fibromyalgia using a phenomenological approach. In the study using phenomenological research method, semi-structured in- depth interviews were conducted with 20 fibromyalgia patients who applied to the neurology outpatient clinic of a state hospital in a province in southern Turkey. Criterion sampling method, one of the purposive sampling methods, was used to reach the sample group. Interviews continued until data saturation was achieved. All interviews were recorded on a voice recorder after obtaining the necessary permissions from the patients and then transcribed. The data of the study were evaluated using thematic analysis. The study was conducted and reported according to the COREQ checklist. Data analysis revealed two main themes (effects of the disease and sexual problems and coping) and five sub-themes (mental, physical, social, problems and coping). As a result of the study, it was determined that the patients experienced serious physical, mental and social problems due to and their sexual life was also negatively affected. Individuals experience significant problems related to sexual life due to fibromyalgia. Since fibromyalgia is a multifaceted disease, professional evaluation of sexual life in patients and diagnosis of sexual dysfunctions are of great importance in terms of improving quality of life.
AtıfScopus1OpenAlex1İncele - MakaleYalnız künye2025Scopus SJRQ3The interaction between the Mediterranean diet, obesity, and disease severity: A case–control study on psoriatic patients
Konyalıgil Öztürk, Nurefşan; Kurtbeyoğlu, Emine; Atuk Kahraman, Tutku; Çiçek, Betül; Çınar, Salih Levent; Borlu, Murat
Background: Psoriasis is a chronic inflammatory disease that can be influenced by nutritional status and dietary habits. In particular, adherence to the Mediterranean diet, known for its anti-inflammatory properties, is increasingly being investigated in relation to disease severity and nutritional status. Aims: This case–control study, including 50 psoriatic patients and 40 healthy controls, aimed to examine the correlation between adherence to the Mediterranean diet and disease severity, nutritional status, and disease presence in patients with psoriasis. Methods: The clinical severity of psoriasis was assessed using the Psoriasis Area and Severity Index (PASI) score. Anthropometric measurements were taken, and body composition was determined using bioelectrical impedance analysis. All participants’ Mediterranean Diet Adherence Screener (PREDIMED) scores and 24-h food consumption records were evaluated. Results: The body weight (BW), waist circumference (WC), hip circumference (HC), and fat mass (FM) values of psoriatic patients were found to be significantly higher than those of the healthy control group (p < 0.05). The PREDIMED score of psoriatic patients was found to be significantly lower than that of the control group (p < 0.001). A negative correlation was observed between the PREDIMED score and BW, FM, and HC (p < 0.05). PASI levels decreased as PREDIMED scores increased (r = −0.314, p = 0.048). According to logistic regression analysis, after adjusting for age and sex, the likelihood of being healthy was approximately 6.363 times higher in those with high adherence to the Mediterranean diet (p < 0.001). Conclusion: When psoriatic patients were compared with healthy controls, significant differences were observed in PREDIMED scores. Notably, greater adherence to the Mediterranean diet was associated with reduced disease severity, suggesting a potential mitigating effect even in the presence of obesity.
AtıfScopus1İncele - MakaleAçık Erişim2025Scopus SJRQ2The Efficacy of Nurse-Delivered Psychosocial and Psychotherapeutic Interventions for Individuals With Mental Health Issues: A Meta-Analysis of Randomised Controlled Trials
Uzun, Sevda; Emirza, Elif Güzide; Gülırmak Güler, Kübra
Background: Nurses are among the most interactive professionals in society, providing both care and psychosocial and psychotherapeutic interventions for individuals with mental health issues. Nurse-centred approaches have demonstrated a positive impact on addressing mental health issues. Aim: This study aimed to evaluate the effectiveness of psychosocial and psychotherapeutic interventions administered by nurses in managing mental health issues. Methods: For this meta-analysis, data were gathered through a comprehensive search of databases, including PubMed, Web of Science, EBSCOhost, Google Scholar and the YÖK Thesis Center, with no restrictions on publication year. Following the review process, a total of 25 studies were included in the analysis. The PRISMA checklist was employed to guide our study. Results: The meta-analysis revealed that interventions implemented by nurses in the context of mental health were effective. Specifically, the psychosocial and psychotherapeutic interventions significantly reduced depression levels in individuals (SMD: −0.918, 95% CI: −1.350 to −0.486; Z = −4.161; p < 0.05) and anxiety levels (SMD: −0.61, 95% CI: −1.190 to −0.029; Z = −2.59; p < 0.05). Additionally, these interventions were associated with an improvement in individuals' quality of life (SMD: 0.673, 95% CI: 0.303–1.403; Z = 3.56; p < 0.05). Conclusion: Nurses can play a pivotal role in addressing mental health issues, effectively contributing to the reduction of anxiety and depression levels while enhancing the overall quality of life for individuals.
AtıfScopus5WoS6OpenAlex6İncele - MakaleYalnız künye2025Scopus SJRQ2Coronavirus anxiety, fear level, and awareness of nursing students starting face-to-face education
Demir Doğan, Melike; Uludağ, Elanur
Aims: This study was designed to determine the coronavirus-associated anxiety, fear, and awareness of nursing students who will start face-to-face education. Methods: In this descriptive and cross-sectional study, the data were collected using the socio-demographic characteristics form, Fear of COVID-19 Scale, Coronavirus Anxiety Scale-Short Form, and COVID-19 Awareness Scale between 29 November 2021 and 1 January 2022. The sample consisted of 344 nursing students. Results: The mean age of the students participating in the study was 20.49±1.78. It was determined that there was a significant difference between gender and the total score of Fear of COVID-19 Scale and the total score of COVID-19 Awareness Scale. Individuals having a nuclear family had significantly higher levels of fear of COVID-19 than those having an extended family. There was a positive and significant relationship between number of vaccinations, age, total score of the Coronavirus anxiety scale, total score of the COVID-19 awareness scale, total score of the hygiene subscale, total score of distance subscale, and total score of mask subscale. It was determined that there was a negative significant correlation between age and the total score of COVID-19 awareness scale and the total score of the Coronavirus anxiety scale. Conclusion: It was determined that women’s levels of fear of COVID-19 and coronavirus awareness levels were significantly higher compared to their male counterparts. The fear of COVID-19 increased as the number of vaccination, age. As the fear of COVID-19 increased, the level of COVID-19 awareness also increased.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ1Protocol for an umbrella review of systematic reviews evaluating the efficacy of digital health solutions in supporting adult cancer survivorship care
Keane, Danielle; Calbimonte, Jean-Paul; Pawlowska, Ewa; Kassianos, Angelos P.; Medina, Joan C.; Gregório, Joao; Serra-Blasco, Maria; Celebic, Aleksandar; Di Meglio, Antonio; Asadi-Azarbaijani, Babak
Introduction The growing number of people living with, through and beyond cancer poses a new challenge for sustainable survivorship care solutions. Digital health solutions which incorporate various information and communication technologies are reshaping healthcare; offering huge potential to facilitate health promotion, support healthcare efficiencies, improve access to healthcare and positively impact health outcomes. Digital health solutions include websites and mobile applications, health information technologies, telehealth solutions, wearable devices, AI-supported chatbots and other technologically assisted provision of health information, communication and services. The breadth and scope of digital health solutions necessitate a synthesis of evidence on their use in supportive care in cancer. This umbrella review will identify, synthesise, and compare systematic reviews which have evaluated the efficacy or effectiveness of digital solutions for adult cancer survivorship care with a particular focus on surveillance and management of physical effects, psychosocial effects, new cancer/ recurring cancers and supporting health promotion and disease prevention.Methods and analysis An umbrella review of published systematic reviews will be undertaken to explore the types of digital health solutions used, their efficacy or effectiveness as a form of supportive care, and the barriers and enablers associated with their implementation. The umbrella review will be reported according to the Preferred Reporting Items for Overviews of Reviews (PRIOR) checklist. A search will be conducted across key databases. Records will be assessed independently by two review authors for eligibility against predefined criteria and will undergo two stage title, abstract and full text screening. All systematic reviews that meet the inclusion criteria will be assessed for quality using the AMSTAR 2 checklist with quality assessment and data extraction by two reviewers. The degree of publication overlap of primary studies across the included reviews will also be calculated and a mapping of the evidence will also be presented.Ethics and dissemination As this research proposes using systematic reviews that are already published, ethical approval is not required. Results from this umbrella review will be published in a peer-reviewed journal where any significant deviations from the protocol will be justified.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ2Real-world comparison of doxorubicin-ifosfamide versus gemcitabine-docetaxel regimens in metastatic uterine leiomyosarcoma: a multicenter retrospective study
Tunbekici, Salih; Sahin, Gokhan; Yuksel, Haydar Cagatay; Acar, Caner; Akin, Imge; Aslanhan, Hasan; Isci, Mert; Kabaoglu, Ceren; Bal, Hamit; Sakin, Abdullah
BackgroundUterine leiomyosarcoma is a rare and aggressive malignancy with limited responsiveness to standard therapies. We conducted a real-world, multicenter study to compare the clinical efficacy and safety of two commonly used first-line chemotherapy regimens-doxorubicin-ifosfamide and gemcitabine-docetaxel-in patients with metastatic uterine leiomyosarcoma.MethodsThis retrospective cohort included 271 patients with advanced or metastatic uterine leiomyosarcoma treated between 2010 and 2023 across 30 centers in Turkey. Patients received either doxorubicin-ifosfamide (n = 142) or gemcitabine-docetaxel (n = 129) as first-line therapy. The primary endpoint was overall survival; secondary endpoints included progression-free survival, objective response rate, disease control rate, and safety. Adverse events were graded according to the Common Terminology Criteria for Adverse Events version 5.0, while survival outcomes were estimated using the Kaplan-Meier method and further analyzed with Cox proportional hazards models.ResultsMedian overall survival was 19.7 months with doxorubicin-ifosfamide and 20.2 months with gemcitabine-docetaxel (P = .26). Median progression-free survival was 5.5 months with doxorubicin-ifosfamide and 7.0 months with gemcitabine-docetaxel (P = .62). The objective response rate was numerically higher with gemcitabine-docetaxel (35% vs. 26%), although not statistically significant (P = .11). Grade 3-4 neutropenia (16% vs. 12%) and febrile neutropenia (7% vs. 6%) were more frequent with doxorubicin-ifosfamide.ConclusionsIn this largest-to-date real-world cohort of metastatic uterine leiomyosarcoma, doxorubicin-ifosfamide and gemcitabine-docetaxel demonstrated comparable survival outcomes. Gemcitabine-docetaxel, however, was associated with a more favorable hematologic safety profile. These findings support the clinical utility of both regimens while underscoring the need for prospective, biomarker-driven studies to refine treatment selection and improve personalization in this rare malignancy.
AtıfOpenAlex2İncele - MakaleAçık Erişim2025Scopus SJRQ1Regorafenib Treatment for Recurrent Glioblastoma Beyond Bevacizumab-Based Therapy: A Large, Multicenter, Real-Life Study
Tünbekici, Salih; Yuksel, Haydar cagatay; Acar, Caner; Sahin, Goekhan; Orman, Seval; Majidova, Nargiz; Coskun, Alper; Seyyar, Mustafa; Dilek, Mehmet siddik; Kara, Mahmut
Background/Objectives: In the REGOMA trial, regorafenib demonstrated an overall survival advantage over lomustine, and it has become a recommended treatment for recurrent glioblastoma in guidelines. This study aimed to evaluate the effectiveness and safety of regorafenib as a third-line treatment for patients with recurrent glioblastoma who progressed while taking bevacizumab-based therapy. Methods: This retrospective, multicenter study in Turkey included 65 patients treated between 2021 and 2023 across 19 oncology centers. The main inclusion criteria were histologically confirmed isocitrate dehydrogenase (IDH)-wildtype glioblastoma, progression after second-line bevacizumab-based treatment, and an Eastern Cooperative Oncology Group (ECOG) performance status score of <= 2. Patients received regorafenib 160 mg once daily for the first 3 weeks of each 4-week cycle. Results: The median age of the patients was 53 years (18-67 years), with a median progression-free survival of 2.5 months (95% Confidence Interval: 2.23-2.75) and a median overall survival of 4.1 months (95% CI: 3.52-4.68). The median overall survival was improved in patients who received subsequent therapy after regorafenib treatment compared with those who did not (p = 0.022). Progression-free survival was longer in patients with ECOG 0-1 than in those with ECOG 2 (p = 0.042). The safety profile was consistent with that of the REGOMA trial, with no drug-related deaths observed. Conclusions: Regorafenib shows good efficacy and safety as a third-line treatment for recurrent glioblastoma after bevacizumab-based therapy. This study supports the use of regorafenib and emphasizes the need for further randomized studies to validate its role and optimize treatment strategies.
AtıfWoS6OpenAlex11İncele - MakaleAçık Erişim2025Scopus SJRQ1Circulating Extracellular Vesicles as Putative Mediators of Cardiovascular Disease in Paediatric Chronic Kidney Disease
Behrens, Felix; Holle, Johannes; Chen, Chia-Yu; Ginsbach, Laura F.; Krause, Benjamin C.; Bruning, Ulrike; Kriegel, Fabian L.; Kaiser, Toralf; Szijarto, Istvan A.; Anandakumar, Harithaa
Cardiovascular disease (CVD) is the leading cause of mortality in chronic kidney disease (CKD). However, the pathogenesis of CVD in CKD remains incompletely understood. Endothelial extracellular vesicles (EC-EVs) have previously been associated with CVD. We hypothesized that CKD alters EV release and cargo, subsequently promoting vascular remodelling. We recruited 94 children with CKD, including patients after kidney transplantation and healthy donors, and performed EV phenotyping and functional EV analyses in the absence of age-related comorbidities. Plasma EC-EVs were increased in haemodialysis patients and decreased after kidney transplantation. Thirty microRNAs were less abundant in total CKD plasma EVs with predicted importance in angiogenesis and smooth muscle cell proliferation. In vitro, CKD plasma EVs induced transcriptomic changes in angiogenesis pathways and functionally impaired angiogenic properties, migration and proliferation in ECs. High shear stress, as generated by arterio-venous fistulas, and uremic toxins were considered as potential drivers of EV release, but only the combination increased EV generation from venous ECs. The resulting EVs recapitulated miRNA changes observed in CKD in vivo. In conclusion, CKD results in the release of EVs with altered miRNA profiles and anti-angiogenic properties, which may mediate vascular pathology in children with CKD. EVs and their miRNA cargo may represent future therapeutic targets to attenuate CVD in CKD.
AtıfWoS7OpenAlex5İncele - MakaleAçık Erişim2025Scopus SJRQ2Low Serum and Urine Fetuin-A Levels and High Composite Dietary Antioxidant Index as Risk Factors for Kidney Stone Formation
Icer, Mehmet Arif; Koçak, Tevfik; Icer, Yusuf; Kocyigit, Emine; Agagündüz, Duygu; Gezmen-Karadag, Makbule; Yesil, Suleyman; Budán, Ferenc
Background: Fetuin-A prevents the precipitation of hydroxyapatite in supersaturated solutions of calcium and phosphate; however, its relationship with nephrolithiasis has yet to be clarified. The aim of this study was to investigate the protective and predictive roles of serum and urine fetuin-A levels in nephrolithiasis and their relationships with the composite dietary antioxidant index (CDAI). Methods: This study involved 75 adult patients with kidney stone disease and 71 healthy adults without kidney stone disease in the control group. Participants had specific anthropometric measurements taken, and three-day food records were kept. The CDAI was calculated by summing six standard antioxidants, including vitamins A, C, and E, manganese, selenium, and zinc, representing participants' antioxidant profile. In addition to some analyzed serum and urine parameters of the participants, fetuin-A levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Results: In patients with kidney stones, both serum and urine fetuin-A levels (676.3 +/- 160.14 ng/mL; 166.6 +/- 128.13 ng/mL, respectively) were lower than in the control group (1455.6 +/- 420.52 ng/mL; 2267.5 +/- 1536.78 ng/mL, respectively) (p < 0.00001). In contrast, the CDAI was higher in patients with kidney stones compared to those without kidney stones (p < 0.001). Besides, several dietary parameters had significant positive correlations with serum and/or urinary fetuin-A. Conclusions: The present study suggests that serum and urinary fetuin-A levels may serve as protective factors against kidney stones and could potentially be used as predictive markers for the development of nephrolithiasis. Furthermore, our results suggest that the CDAI above a certain level may increase the risk of stone formation and that some dietary parameters may affect the levels of this biomarker in serum and urine.
AtıfScopus6WoS5OpenAlex7İncele - MakaleAçık Erişim2025Scopus SJRQ2Inspiratory muscle training in natural bodybuilders: adaptations in diaphragm muscle thickness and maximal strength
Güler, Iskender; Yilmaz, Coskun; Soylu, Hakan Hueseyin; Birinci, Muersit Ceyhun; Arslan, Ayla; Ocak, Hakan; Çayir, Huseyin; Kavuran, Korhan; Saç, Ajlan; Uçar, Mine Akkus
Background: The effect of inspiratory muscle training on diaphragm muscle thickness (DT) and one repetition maximal (1RM) in professional natural bodybuilders is still unclear. The aim of the study was to investigate the effect of inspiratory muscle training on diaphragm muscle thickness and 1RM in professional natural bodybuilders. Methods: The study comprised a total of 22 athletes who participated in bodybuilding competitions. Each athlete had undergone a minimum of 5 years of training, with a minimum weekly commitment of 5 hours. Participants were randomly divided into two groups: inspiratory muscle training (IMT) and control (CON). The CON continued their normal training regime, while the IMT group also performed inspiratory muscle training with a 10% weekly increase by setting the resistance setting of the PowerBreathe (R) Classic device to 40% of the participant's maximum inspiratory pressure (MIP). Prior to and during the 4-week training period, 1RM bench press measurements and diaphragm muscle thickness measurements were obtained. Results: In the comparison of 1RM power values before and after training, it was determined that the IMT group (%: 11.20) had 6.3% more post-activation performance enhancement compared to the CON group (%: 4.9) (p < 0.001). In the study, it was determined that a higher level of significant post-activation performance enhancement was obtained in the IMT group compared to the CON group in the diaphragm muscle thickness inspiratory phase (DT ins) and ekspiratory phase (DT eks) parameters at 20.36% and 19.46%, respectively. Conclusion: In conclusion, we determined that the addition of progressive loading inspiratory muscle training to preparation programmes in natural bodybuilders will improve diaphragm muscle thickness, 1RM physical performance. In particular, it shows that the diaphragm muscle should be considered not only as a muscle that supports respiration, but also as a muscle that contributes to power generation by optimising intra-abdominal pressure.
AtıfScopus5WoS5OpenAlex5İncele - MakaleAçık Erişim2025Scopus SJRQ1Judo exercises increase emotional expression, self-control, and psychological resilience
Köroglu, Mihrac; Yilmaz, Coskun; Tan, Cetin; Çelikel, Baha Engin; Budak, Cemalettin; Kavuran, Korhan; Susuz, Yunus Emre; Barut, Yasar; Ceylan, Tulay; Soyer, Fikret
Background: The extant research on judo sports has principally concentrated on the physiological effects of training. Conversely, there has been limited attention paid to studies on psychological resilience, self-control, and emotional expression levels. The present study examined the effects of Judo exercises on psychological resilience, self-control, and emotional expression levels in healthy male subjects. Methods: The present study comprised 50 healthy, sedentary male subjects. The subjects were randomly divided into two groups: one group participated in judo training (JT) and the other group served as the control group (CON). The sample sizes for the JT and CON groups were both 25. The JT group underwent judo training, while the CON group maintained their usual lifestyle. The Brief Psychological Resilience Scale, the Multidimensional Brief Self-Control Scale, and the Berkeley Emotion Expression Scale were administered prior to and following the 6-week training period. Results: The study demonstrated that a 6-week judo training regimen exerted a significant effect on the psychological resilience score (e.s. = 1.047, p < 0.001), while no such effect was observed in the Control group (e.s. = 0.0091, p = 0.751). In the context of self-control levels, an effect was observed on the Initiation sub-dimension (e.s. = 1, 739, p < 0.001), yet no effect was found on the Inhibition dimension (e.s. = 0.052, p = 0.892). In the control group, a significant decrease was identified in the Initiation sub-dimension (e.s. = 0, 785, p = 0.001) and Inhibition sub-dimension (e.s. = 1, 861, p < 0.001). The findings indicate that impulse power (e.s. = 0.395) and concealment (e.s. = 0.428) exerted a negligible influence on the emotional expression sub-dimensions. Conversely, psychological resilience (e.s. = 0.886) demonstrated a substantial impact. Conclusions: The judo exercises demonstrated a favorable impact on psychological resilience, self-control, and emotional expression levels in healthy male subjects. The findings of this study may offer significant insights into the impact of judo exercises on psychological resilience, self-control, and emotion expression levels. These findings could serve as a guide for the development of future interventions and program design in the domain of sport psychology.
AtıfScopus9WoS10OpenAlex11İncele - MakaleAçık Erişim2025Scopus SJRQ3Investigation of the relationship between apelin hormone response and some physiological parameters in enzootic bovine leukosis virus infected cattle
Sait, A.; Bayraktar, B.; Korkmaz, S.; Genç, M.; Bayraktar, S.; Kotan, G. C.; Aydemir, S.; Takma, C.; Bülbül, A. S.; Aksakal, V
Apelin is a hormone with lymphangiogenesis potential, associated with tumor growth and lymph node metastasis, and is reported to stimulate tumor vascularization. This study aimed to investigate the response of the apelin hormone in cattle with and without Enzootic Bovine Leukosis (EBL) infection, based on physiological parameters such as breed, age, and body condition score (BCS). A total of 120 Simmental and Montafon cattle of varying ages (<2, 2-8, and >8) and BCS categories (<2, 3-3.5, and >= 4) were included in the study. Serum apelin hormone levels were measured using the ELISA technique in blood samples collected from the neck vein ( Vena jugularis) of the animals. The analysis of mean serum apelin (ng/mL) values revealed that, among EBL-positive cattle, the highest value was 2.77 ng/mL in Simmental cattle aged 2-8 years with a BCS of 3-3.5, while a value of 2.69 ng/mL was observed in Montafon cattle aged >8 years with a BCS of 3-3.5. For EBL-negative cattle, the highest mean serum apelin value was 2.24 ng/mL, recorded in Simmental cattle aged 2-8 years with a BCS of 3-3.5, whereas it was 1.45 ng/mL in Montafon cattle aged >8 years with the same BCS. In conclusion, this study demonstrated for the first time the effect of apelin hormone levels in cattle with or without EBL, depending on physiological parameters such as age, breed, and BCS. It is suggested that the apelin hormone, which is involved in neoplastic lymphocyte cell infiltration in the lymphoreticular tissues of cattle, and plays a role in regulating tumor growth in EBL, a malignant tumor disease, may contribute to eradication programs. Moreover, the evaluated parameters may prove valuable for disease prevention and control strategies.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ3ACTN3, IL-6 AND PPARA GENE POLYMORPHISMS AND ANAEROBIC PERFORMANCE IN VOLLEYBALL PLAYERS
Ön, Sadi; Can, Ibrahim; Bayrakdaroglu, Serdar; Sever, Mehmet Onur; Diker, Gurkan; Özkamçi, Huseyin; Zileli, Raif; Söyler, Mehmet; Yilmaz, Ozlem Ozge; Polat, Tolga
The aim of this study is to determine the relationship between ACTN3 rs1815739, IL-6 rs1800795, and PPARA rs4253778 gene polymorphisms and anaerobic test parameters among volleyball players. A total of 22 volleyball players voluntarily participated in the study. DNA isolation from buccal epithelial cell samples were performed using a PureLink DNA isolation kit, following the manufacturer's instructions. The genotyping of ACTN3 rs1815739, IL-6 rs1800795, and PPARA rs4253778 gene polymorphisms were determined using the real-time polymerase chain reaction technique. Statistical analysis of the test results was performed using the SPSS 23 software package. Homogeneity of variance was assessed with the Levene test, and normal distribution was evaluated using the Shapiro-Wilk test. The One-Way ANOVA test was applied for the analysis of all parameters, and significance was set at p < 0.05. When the data were evaluated, no statistically significant differences were observed between PPARA rs4253778 and ACTN3 rs1815739 gene polymorphisms and anaerobic performance parameters (p>0.05). Statistically significant differences were observed between the IL-6 rs1800795 gene polymorphism and anaerobic performance parameters of back strength (p> 0.05). In conclusion, in volleyball, PPARA rs4253778 andACTN3 rs1815739 gene polymorphisms did not cause differentiation in anaerobic performance parameters. However, IL-6 gene polymorphism caused differentiation only in the back strength parameter. Additionally, the good performance of athletes with different prevalent level of genotypes in the studied performance criteria does not fully reveal which performance outcomes are influenced by the gene or genotype distributions. It is understood that further studies are needed to better determine the gene-performance relationship.
- MakaleAçık Erişim2025Scopus SJRQ1Exploring how cognitive-behavioral physical activity links ruminative thinking and mental wellbeing in sports high school adolescents
Derelioglu, Mehmet; Vural, Mustafa; Çimen, Erkan; Saki, Unal; Yagiz Saracoglu, Yusuf; Karatas, Baykal; Saç, Ajlan; Yamaner, Emre; Halmatov, Medera; Yilmaz, Coskun
Introduction: This study examined the associations among ruminative thinking style (RTS), subjective wellbeing (SWB), and cognitive-behavioral physical activity (CBPA) in a sample of 1,326 adolescents (aged 14-18) from sports high schools. Method: Using validated self-report measures, data were analyzed through bootstrapped mediation models. Results: RTS was negatively associated with SWB (beta = -0.1792, p < 0.001), while CBPA showed a partial mediating effect in this relationship (indirect beta = 0.0779, p < 0.001). Discussion: These results suggest that cognitive-behavioral orientations toward physical activity may buffer the negative impact of rumination on wellbeing. Consistent with cognitive-behavioral therapy (CBT) principles, CBPA could provide adolescents with self-regulatory strategies that support mental health. However, the cross-sectional and self-report design, as well as the focus on sports high school students, limit causal inference and generalizability. Future longitudinal and cross-cultural studies are needed to confirm these findings. Overall, the study provides preliminary evidence that CBPA-informed approaches may hold promise for promoting adolescents' mental wellbeing.
AtıfScopus12WoS10OpenAlex11İncele - MakaleAçık Erişim2025Scopus SJRQ1Sulfonamide-Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME/T Profiling and Molecular Docking Study
Lolak, Nebih; Akocak, Suleyman; Topal, Meryem; Koçyigit, Umit Muhammet; Isik, Mesut; Türkes, Cuneyt; Topal, Fevzi; Durgun, Mustafa; Beydemir, Sukru
The research and design of new inhibitors for the treatment of diseases such as Alzheimer's disease and glaucoma through inhibition of cholinesterases (ChEs; acetylcholinesterase, AChE and butyrylcholinesterase, BChE) and carbonic anhydrase enzymes are among the important targets. Here, a series of novel sulfonamide-bearing pyrazolone derivatives (1a-f and 2a-f) were successfully synthesized and characterized by using spectroscopic and analytical methods. The inhibitory activities of these newly synthesized compounds were evaluated both in vitro and in silico for their effect on carbonic anhydrases (hCA I and hCA II isoenzymes) and ChEs. The in vitro studies showed that these novel compounds demonstrated potential inhibitory activity, with K-I values covering the following ranges: 18.03 +/- 2.86-75.54 +/- 4.91 nM for hCA I, 24.84 +/- 1.57-85.42 +/- 6.60 nM for hCA II, 7.45 +/- 0.98-16.04 +/- 1.60 nM for AChE, and 34.78 +/- 5.88-135.70 +/- 17.39 nM for BChE. Additionally, many of these compounds showed promising inhibitory activity, and some showed higher potency than reference compounds. While the in silico studies have also identified the potential binding positions of these compounds, using the crystal structures of hCA I, II, AChE and BChE receptors. The varying affinities demonstrated by these designed compounds for ChEs and hCA isoenzymes show that these compounds could hold promise as potential alternative agents for selectively inhibiting ChEs and hCAs in the treatment of diseases such as Alzheimer's disease and glaucoma.
AtıfScopus21WoS22OpenAlex21İncele - MakaleAçık Erişim2025Scopus SJRQ2Maximizing performance in child footballers: chronotype and time of day study
Kaba, Ilknur; Engin Celikel, Baha; Adanur, Oguzhan; Yilmaz, Coskun; Yonca Sezer, Sureyya; Tan, Cetin; Durhan, Tebessum Ayyildiz; Özer, Ugur; Ceylan, Tulay
Background A limited number of studies have investigated the effects of circadian rhythm-based running exercise interventions on physical fitness in child athletes. This study aimed to investigate the effects of an eight-week morning and evening running program on lower extremity strength, agility and respiratory function in 10-12-year-old male footballers.Methods Participants visited the laboratory three times, with one-day intervals before and after the training program. The assessments included maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio. Additionally, agility and functional performance tests (FPTs) were conducted for both the dominant and non-dominant legs.Results The findings indicated that morning running was more effective than evening running in enhancing respiratory function. Morning running also showed superior results in lower extremity strength tests, particularly in the single-leg (SL) and triple-leg (THD) crossover hop for distance tests (CHDs) and the 6-m timed-hop test (6 m THT). Furthermore, the agility performance of the morning running group was significantly better than that of the evening and control groups.Conclusion Consequently, morning running interventions had a positive impact on key physical fitness parameters, including respiratory muscle strength, respiratory function, agility, and lower extremity strength in child footballers.
- MakaleYayıncıda açık erişim2025Scopus SJRQ2Could Different Doses of Dexmedetomidine Be as Effective as Amifostine Against Radiotherapy-Induced Liver Injury in Rats? Evidence from Mitotic, Apoptotic, Oxidative, and Neurogenic Insights
Beyazal Polat, Hatice; Yilmaz, Hamit; Demir, Kasim; Kilinc, Kagan; Gülhan, Belemir; Rakici, Sema Yilmaz; Tumkaya, Levent
Background/Objectives: Radiotherapy (RT) induces oxidative stress and structural damage in solid tissues, including the liver. This study aimed to investigate the histological and immunohistochemical effects of dexmedetomidine (DEX) and amifostine on their potential protective and regenerative properties against liver injury induced by radiation therapy. Methods: This study consisted of five randomized groups: control, RT, RT-D100, RT-D200, and RT-A (Amifostine). A total of 100 mu g/kg DEX, 200 mu g/kg DEX, and 200 mu g/kg amifostine were administered before radiotherapy as per the experimental design. After RT, liver specimens were analyzed for histological alterations, including periportal and perisinusoidal fibrosis, vacuolization, and pyknotic nuclei. Furthermore, immunohistochemistry investigations were conducted to evaluate apoptosis, mitosis, oxidative stress, and neural regeneration in non-neuronal liver tissue following radiotherapy and subsequent treatment. Results: The control group's liver tissue exhibited standard histological architecture, whereas the RT group displayed severe cellular degeneration, periportal and perisinusoidal fibrosis, cytoplasmic vacuolization, and an increase in pyknotic nuclei. The apoptotic index was markedly reduced in the RT-D100 and RT-D200 groups relative to the RT group. Furthermore, caspase-3 immunoactivity was negligible in the control group, while a significant increase was observed in the RT group. The administration of amifostine significantly increased GAP-43 levels. Conclusions: DEX mitigates RT-induced hepatic injury chiefly through antioxidant and anti-apoptotic pathways, whereas amifostine promotes hepatic regeneration by modulating GAP-43.
- MakaleAçık Erişim2025Scopus SJRQ2Effect of Inspiratory Muscle Training on Diaphragm and Abdominal Wall Muscle Thickness with Fatty Liver Density in Elderly Women: A Randomized Controlled Trial
Gökçelik, Eda; Yilmaz, Coskun; Budak, Cemallettin; Soylu, Hakan Huseyin; Bayrakdaroglu, Serdar; Ceylan, Halil Ibrahim; Muntean, Raul Ioan; Küçük, Hamza; Ceylan, Levent
Background and Objectives: Post-menopausal estrogen decline is considered a contributing factor to sarcopenia, and inspiratory muscle training (IMT) may provide benefits in this demographic. This study examined the impact of a four-week IMT program on diaphragm thickness, abdominal wall muscle thickness (AWMT; transversus abdominis, internal oblique, and external oblique), and liver fat percentage in healthy elderly women. Materials and Methods: Twenty-six women aged 60-80 years were randomly assigned to an IMT group (n = 13) or a control group (n = 13). The IMT group used the PowerBreathe (R) Classic device at 40% of maximal inspiratory pressure (MIP), with weekly increments of 10%. Training was performed twice daily, five days per week, with 30 breathing cycles per session (60 per day). The control group maintained their usual routines. AWMT, diaphragm thickness (DT), and fatty liver density (FLD) were measured by a radiologist before and after the intervention. Results: After four weeks, the IMT group showed significant improvements in all parameters compared to controls. Mid-diaphragm thickness (MDT) increased by 11.44% (effect size (ES) = 0.358, p < 0.001) versus 0.76% in controls (p = 0.271). Posterior diaphragm thickness (PDT) improved by 7.48% (ES = 0.282, p < 0.001) versus 0.38% (p = 0.564). Right AWMT increased by 12.7% (ES = 0.492, p < 0.001) compared to 0.10% (p = 0.872), and left AWMT increased by 9.93% (ES = 0.395, p < 0.001) versus 2.64% (p = 0.014). FLD improved by 11.79% (ES = 0.959, p < 0.001) in the IMT group, while the control group showed no meaningful change (-0.13%, p = 0.847). Conclusions: A short-term IMT protocol significantly enhanced diaphragm and AWMT and reduced liver fat in elderly women. These findings support the use of IMT as a simple, non-invasive intervention to preserve musculoskeletal and metabolic health in aging populations.
AtıfScopus4WoS4OpenAlex6İncele
