Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Demir, Selim(12)
- Turan, Ibrahim(11)
- Aliyazicioglu, Yuksel(8)
- Topal, Meryem(7)
- Şengül, Mustafa(6)
- Baltaci, Cemalettin(5)
- Topal, Fevzi(5)
- Öz, Mehmet(5)
- Ürkek, Bayram(5)
- Akar, Zeynep(4)
- Alwasel, Saleh H.(4)
- Durmaz, Lokman(4)
- Gulcin, Ilhami(4)
- Gülçin, Ilhami(4)
- Akmeşe, Osman(3)
- Bingol, Zeynebe(3)
- Gören, Ahmet C.(3)
- Karatas, Seyda Merve(3)
- Misir, Sema(3)
- Turan, İbrahim(3)
- Yapıcı, İsmail(3)
- Yildiz, Hilal(3)
- Aliyazicioglu, Yüksel(2)
- Altay, Kadriye(2)
- Baltacı, Cemalettin(2)
- Deger, Orhan(2)
- Fidan, Muhammed Said(2)
- Gocer, Hulya(2)
- Gül, Abdulkadir(2)
- Gültekin, Ergün(2)
- Gülçin, İlhami(2)
- Kalin, Pinar(2)
- Kiziltas, Hatice(2)
- Kose, Leyla Polat(2)
- Küçük, Murat(2)
- Okan, Onur Tolga(2)
- Sarikaya, S. Beyza Öztürk(2)
- Ucuncu, Osman(2)
- Şengül, Memnune(2)
- AKMEŞE, Osman(1)
Yayınlar
- MakaleYalnız künye2018Scopus SJRQ3In vitro antioxidant and antimicrobial activities of the five different solvent extracts of Centaurea pulcherrima var. Freynii from Turkey
Ozcan, Kadriye; Acet, Tuba
Various extracts of Centaurea pulcherrima var. freynii were investigated for total phenolic, flavonoid, antioxidant and antimicrobial activities. The antioxidant properties of plant extracts were evaluated by free radical scavenging assays (DPPH and ABTS). Antimicrobial activities were examined using disc diffusion methods. According to the results of antioxidant capacity assays, the plant showed moderately antioxidant activity in test methods. It was found that ethyl acetate extract showed the most effective activity including total phenolic, flavonoid, antioxidant and antimicrobial activities.
AtıfScopus11WoS10
İncele - MakaleAçık Erişim2017Evaluation of Antioxidant and Cytotoxic Properties of Primula vulgaris Leaf Extract
Turan, Ibrahim; Demir, Selim; Aliyazicioglu, Rezzan; Aliyazicioglu, Yuksel
Primula vulgaris belongs to the genus Primula and this genus is frequently used in traditional medicine. Numerous studies reported the antioxidant and cytotoxic effects of various extracts of different Primula species but, there were limited studies of the antioxidant and cytotoxic effect of P. vulgaris. The aim of this study was to determine the antioxidant properties and cytotoxic effects of dimethyl sulfoxide extract of leaves of P. vulgaris. The total polyphenolic content (TPC), total flavonoid content (TFC) and reducing antioxidant power of extract were evaluated using spectrophotometric procedures. The cytotoxic effects of extract were revealed on human lung (A549), liver (HepG2), breast (MCF-7), prostate (PC-3), and colon (WiDr) cancer cell lines and normal fibroblast cells using thiazolyl blue tetrazolium bromide (MTT) assay. TPC and FRAP values were 1890.1 +/- 11.2 mg gallic acid equivalents and 3233.1 +/- 176.2 mg trolox equivalents per 100 g sample, respectively. The extract showed selective cytotoxic effects on all studied cancer cell lines compared to normal fibroblast cells and IC50 values ranged from 133.3-253.8 mu g/mL. This is the first study to reveal the antioxidant properties of P. vulgaris leaf extract and its cytotoxic effect on cancer cell lines. Further studies are now needed to identify the antioxidant and cytotoxic molecules in the extract and their mechanisms.
AtıfWoS15OpenAlex6İncele - MakaleAçık Erişim2017Scopus SJRQ3Cytotoxic effect of Laurocerasus officinalis extract on human cancer cell lines; [Laurocerasus officinalis ekstraktının İnsan kanser hücre serileri üzerindeki sitotoksik etkisi]
Demİr, Selim; Turan, İbrahim; Demİr, Feyza; Ayazoğlu Demİr, Elif; Alıyazicioğlu, Yuksel
Laurocerasus officinalis Roem. (Prunus laurocerasus L.), also locally known as “karayemis or taflan”, is a popular black summer fruit belonging to the genus Prunus and the family Rosaceae. L. officinalis exhibits numerous biological activities, such as anti-inflammatory, antinociceptive, antioxidant, neuroprotective, and antidiabetic effects. The aim of this study was to determine the total phenolic content and cytotoxic effect of dimethyl sulfoxide extract of L. officinalis (DEL). The total phenolic content and cytotoxic effect of DEL were investigated using the Folin-Ciocalteu method and thiazolyl blue tetrazolium bromide (MTT) assay, respectively. Total phenolic content value was 33.7±0.13 mg gallic acid equivalent per g sample. DEL exhibited selective cytotoxic effects against four human cancer (lung, colon, liver, and cervix) cell lines. The most selective cytotoxic effect of the extract was observed in colon cancer cells (IC50=265.2±8.1 μg/mL) compared to normal fibroblast cells. These data demonstrate that L. officinalis extract exhibits selective cytotoxicity towards some cancer cells. Further studies are now needed to clarify the molecules involved and their mechanisms.
AtıfScopus17WoS21OpenAlex34TR Dizin14
İncele - MakaleAçık Erişim2017Scopus SJRQ3Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands
Ayvaz, Melekcol; Turan, Ibrahim; Dural, Bayram; Demir, Selim; Karaoglu, Kaan; Aliyazicioglu, Yuksel; Serbest, Kerim
Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) transition metal complexes of 2-hydroxy-5-[(E)-(4-phenyl) diazenyl] benzaldehyde oxime and 2-hydroxy-5-[(E)-(4-nitrophenyl) diazenyl] benzaldehyde oxime ligands were synthesized and characterized through NMR, IR, ESI mass, and UV analysis. DNA binding abilities of the complexes were revealed using a UV-Vis spectrophotometer with the absorption titration and competitive binding techniques. Hydrolytic and oxidative DNA cleavage activities under different conditions were also proved. Topoisomerase I inhibition efficiencies and in vitro free radical scavenging activities of all complexes were examined. Finally, the selective cytotoxic potentials of all complexes were evaluated in human colon cancer, normal colon, and fibroblast cell lines using the water-soluble tetrazolium salt (WST-1) assay. The complexes had the ability to intercalate into stacked base pairs of DNA and topoisomerase I activity was reasonably inhibited in their presence in 0.4 mM concentrations. The abilities for scavenging of DPPH and hydroxyl radicals were found to be higher than those of known standard antioxidants (ascorbic acid, butylated hydroxyanisole, and mannitol). The results obtained from the cytotoxicity experiments are especially promising for further research, which must be carried out for the evaluation of the studied complexes as anticancer drugs.
AtıfScopus8WoS8OpenAlex8TR Dizin2İncele - MakaleAçık Erişim2017Scopus SJRQ2Accumulation of phenolics in natural and micropropagated plantlets of Thymus pseudopulegioides Klokov & Des.-Shost. with their antioxidant potentials
Günaydin, Mustafa; Laghari, Abdul Hafeez; Bektas, Ersan; Sökmen, Munevver; Sökmen, Atalay
Thymus pseudopulegioides plantlets were propagated in vitro via direct organogenesis by using Murashige and Skoog (MS) media containing kinetin, thidiazuron, and 6-benzyladenine (BA) individually. Methanol extracts obtained both from plantlets and wild plants were analyzed for their total phenolics and flavonoid contents, then quantified by HPLC. The highest total phenolic (8.83 mg/g as gallic acid equivalent) and total flavonoid (0.92 mg/mL as rutin equivalent) values were from the MS media supplemented with 1.0 mg/L kinetin and 0.5 mg/L BA, respectively. The plantlets grown in those media also showed remarkable antioxidant activities with an IC50 value of 4.77 mu g/mL in DPPH and 100% inhibition in beta-carotene assays, respectively. HPLC analysis proved the production of protocatechuic, caffeic, vanillic, rosmarinic, ferulic, and o-coumaric acids and rutin. Rosmarinic acid production was predominant in natural samples (115.2 mg/100 g dry weight), while the aforesaid phenolic acids were prevalent in plantlets grown on MS media supplemented with KIN or BA at various concentrations. Rutin production was the highest (50.74 mg/100 g dry weight) in the plantlets grown on MS medium containing kinetin (1.0 mg/L). As an economically important chemical, rosmarinic acid was selected as the target chemical and a novel method was introduced to achieve its selective isolation.
AtıfScopus6WoS5OpenAlex9TR Dizin2İncele - MakaleYalnız künye2016Scopus SJRQ1Application of response surface methodology for optimizing the recovery of phenolic compounds from hazelnut skin using different extraction methods
Odabaş, Halil İbrahim; Koca, Ilkay
Hazelnut skin which is a rich source of phenolic compounds is a by-product of hazelnut roasting process. In present study, ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE) and supercritical carbon dioxide extraction (SCE) methods were applied for recovery of phenolic compounds from hazelnut skin. Response surface methodology was used to estimate optimum extraction conditions. Extraction studies were performed according to Box-Behnken Design. Temperature (UAE)/power (MAE), time and ethanol concentration were independent variables for UAE and MAE. The independent variables selected for SCE were temperature, time and pressure. The optimum extraction conditions were 45 min and 67.2–67.6% ethanol concentration, 600 W, 6 min and 55.03–56.23% ethanol concentration and 42.72–49.10 °C, 59.83–60.00 min and 10.01–11.48 bar, for UAE, MAE and SCE respectively. Total phenolic content, FRAP and 1/EC50 values at the optimum conditions were 122.99–123.01 mg GAE/g, 612.20–613.25 mmol Fe(II)/g and 4.36 mL/mg for UAE, 111.53–111.55 mg GAE/g, 582.44–582.52 mmol Fe(II)/g and 2.48 mL/mg for MAE and 69.59–72.64 mg GAE/g, 426.25–465.52 mmol Fe(II)/g and 2.18–2.27 mL/mg for SCE, respectively. Maceration was performed for comparison with novel methods. UAE was found to be the best method of the extraction of phenolic compounds from hazelnut skin with the highest total phenolic content and antioxidant activity values.
AtıfScopus89WoS78OpenAlex97İncele - BildiriYalnız künye2016Scopus SJRQ4Comparison of the antioxidant properties of some onion and garlic cultivars grown in Turkey
Koca, I.; Tekguler, B.; Odabas, H.I.; Gokce, A.F.
Garlic and onions are widely consumed among the vegetables in Turkey. The objective of this study was to determine the antioxidant properties of red, yellow and white onions, and Chinese and Taşköprü garlics grown in Turkey. The color, dry matter, total soluble solids, total phenolics and antioxidant activity values of the samples were determined. Total phenolic content was studied by the Folin-Ciocalteu method expressed as mg gallic acid equivalents g-1 dry weight (mg GAE g-1 DW), while antioxidant activity was analysed using two different methods as ferric reducing antioxidant power (FRAP, mmol Fe2+ g-1 DW) and, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Red onions had the highest total phenolic contents ranged from 6.60 to 9.85 mg GAE g-1 DW (8.40±1.06 mg GAE g-1 DW). The total phenolic contents of yellow onions, white onions, Chinese garlics and Taşköprü garlics were found as 4.41-9.55 mg GAE g-1 DW (7.19±1.96 mg GAE g-1 DW), 1.73-3.09 mg GAE g-1 DW (2.16±0.47 mg g-1 DW), 2.05-3.34 mg GAE g-1 DW (2.64±0.45 mg g-1 DW) and 1.05 to 2.08 mg GAE g-1 DW (1.59±0.38 mg GAE g-1 DW), respectively. Also, red onions had the highest antioxidant activity at 8.50±4.85 mmol Fe2+ g-1 DW and 69.68±15.95% for FRAP and DPPH assays, respectively. FRAP values of yellow onions, white onions, Chinese garlics and Taşköprü garlics were found as 3.84±2.02 mmol Fe2+g-1 DW, 1.46±0.43 mmol Fe2+ g-1 DW, 2.03±0.57 mmol Fe2+ g-1 DW and 1.26±0.32 mmol Fe+2 g-1 DW, respectively. DPPH radical scavenging activity (the percentage of DPPH reduced by 14.3 mg mL-1 extract) of yellow onions (42.25±8.32%) was higher than white onions (11.57±0.71%). DPPH radical scavenging activity of the garlic extracts (14.3 mg mL-1) was found to be less than 2%. In the present study, the highest antioxidant activity and total phenolics were found in red onions, while the lowest values was Taşköprü garlics.
AtıfScopus3WoS3OpenAlex6İncele - MakaleAçık Erişim2016Scopus SJRQ2Antioxidant activity of taxifolin: An activity-structure relationship
Topal, Fevzi; Nar, Meryem; Gocer, Hulya; Kalin, Pinar; Kocyigit, Umit M.; Gülçin, Ilhami; Alwasel, Saleh H.
Taxifolin is a kind of flavanonol, whose biological ability. The objectives of this study were to investigate the antioxidants and antiradical activities of taxifolin by using different in vitro bioanalytical antioxidant methods including DMPD•+, ABTS•+, and DPPH•-scavenging effects, the total antioxidant influence, reducing capabilities, and Fe2+-chelating activities. Taxifolin demonstrated 81.02% inhibition of linoleic acid emulsion peroxidation at 30 μg/mL concentration. At the same concentration, standard antioxidants including trolox, α-tocopherol, BHT, and BHA exhibited inhibitions of linoleic acid emulsion as 88.57, 73.88, 94.29, and 90.12%, respectively. Also, taxifolin exhibited effective DMPD•+, ABTS•+, and DPPH•-scavenging effects, reducing capabilities, and Fe2+-chelating effects. The results obtained from this study clearly showed that taxifolin had marked antioxidant, reducing ability, radical scavenging and metal-chelating activities. Also, this study exhibits a scientific shore for the significant antioxidant activity of taxifolin and its structure-activity insight.
AtıfScopus290WoS255OpenAlex306
İncele - MakaleAçık Erişim2016Scopus SJRQ2Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.)
Topal, Meryem; Gocer, Hulya; Topal, Fevzi; Kalin, Pinar; Köse, Leyla Polat; Gulçin, Ilhami; Çakmak, Kader C.; Küçük, Murat; Durmaz, Lokman; Gören, Ahmet C.
Cynarin is a derivative of hydroxycinnamic acid and it has biologically active functional groups constituent of some plants and food. We elucidated the antioxidant activity of cynarin by using different in vitro condition bioanalytical antioxidant assays like DMPD•+, ABTS•+, DPPH• and H2O2 scavenging effects, the total antioxidant influence, reducing capabilities, Fe2+ chelating and anticholinergic activities. Cynarin demonstrated 87.72% inhibition of linoleic acid lipid peroxidation at 30 g/mL concentration. Conversely, some standard antioxidants like trolox, tocopherol, butylated hydroxytoluene (BHT), and butylated hydroxyanisole (BHA) exhibited inhibitions of 90.32, 75.26, 97.61, 87.30%, and opponent peroxidation of linoleic acid emulsion at the identical concentration, seriatim. Also, cynarin exhibited effective DMPD•+, ABTS•+, DPPH•, and H2O2 scavenging effects, reducing capabilities and Fe2+ chelating effects. On the contrary, IC50 and Ki parameters of cynarin for acetylcholinesterase enzyme inhibition were determined as 243.67 nM (r2: 0.9444) and 39.34 ± 13.88 nM, respectively. This study clearly showed that cynarin had marked antioxidant, anticholinergic, reducing ability, radical-scavenging, and metal-binding activities.
AtıfScopus169WoS156OpenAlex169İncele - MakaleAçık Erişim2016Scopus SJRQ3Physicochemical and bioactive properties of cakes incorporated with gilaburu fruit (Viburnum opulus) pomace
Şeker, I.T.; Ertop, M.H.; Hayta, M.
In this study the valorisation of a gilaburu (Viburnum opulus) fruit pomace, a waste product remaining after juice extraction, was investigated. The pomace was incorporated into cake formulation at the level of 0, 5, 10 and 15%, based on wheat flour weight. Results indicated that the batter viscosity increased and pH decreased by the increasing of the concentration of pomace level in cake formulation. Depending on incorporation level, reduction on the volume and height of the cake samples were observed. The hardness values increased whereas the chewiness and gumminess values of the cake samples decreased with an increasing of pomace incorporation level. Gilaburu pomace addition caused significant (P<0.05) changes on L*, a*, and b* values of crumb, whereas no significant differences have been determined on the L* and b* values of crust of the samples. In sensory analyses, 5% gilaburu pomace added cake sample had the highest overall acceptability score. The total phenolic content and radical-scavenging activity values of cake samples increased proportionally with the level of pomace incorporation. According to the study, evaluation of gilaburu pomace waste as ingredient in developing alternative functional and/or value-added products by the food industry could be suggested.
AtıfScopus13WoS12OpenAlex16İncele - MakaleYalnız künye2016Scopus SJRQ3Selective cytotoxic effect of Rhododendron luteum extract on human colon and liver cancer cells
Demir, Selim; Turan, Ibrahim; Aliyazicioglu, Yuksel
Purpose: The genus Rhododendron is distributed entirely in the world with the exception of South and Central America and Africa, growing in a large diversity of climatic conditions. This genus is a rich source of phenolic compounds, especially flavonoids, essential oils, chromones, terpenoids, and steroids. It has many biological properties such as antioxidant, anti-inflammatory, antiviral, antibacterial, anticancer, antidiabetic, immunomodulatory, cardioprotective and hepatoprotective among others due to their polyphenolic constituents. The objective of the current study was to evaluate the antioxidant properties and cytotoxic activity of dimethyl sulfoxide extract of flowers of Rhododendron luteum (DEFR) for the first time. Methods: The total polyphenolic contents (TPC), total flavonoid contents (TFC) and ferric reducing antioxidant power (FRAP) of the extract were evaluated using spectrophotometry procedures. The cytotoxic activity of the extract on three cancers (human breast, colon and liver carcinoma) and human foreskin fibroblast cells was determined using the MTT assay. Results: TPC and FRAP values were found 54.2+.0.38 mg gallic acid equivalents and 164.2±1.77 mg trolox equivalents per to g sample, respectively. R. luteum extract exhibited selective cytotoxicity against colon and liver cancer cells compared to normal fibroblast cells, while this selective cytotoxicity was not observed in breast cancer cells. Conclusion: Our results demonstrate that the Rhododendron luteum may be a great source of antioxidant and antitumor natural agents due to their capability of decreasing cancer cells proliferation.
AtıfScopus25WoS29İncele - MakaleAçık Erişim2015Scopus SJRQ1Acethylcholinesterase inhibitory potential and antioxidant properties of pyrogallol
Ozturk Sarikaya, S. Beyza
Pyrogallol is found naturally in crops and fruits of many plants. It is also an active ingredient of many pharmaceuticals. For this reason, we employed different in vitro antioxidant assays such as cupric ion Cu2+ reducing power, Fe3+ reducing power, total antioxidant activity by ferric thiocyanate method, ABTS radical scavenging, DMPD radical scavenging, DPPH • scavenging, Fe2+ chelating, O2•- scavenging and H2O2 scavenging activities of pyrogallol. Pyrogallol inhibited 77.95% lipid peroxidation of linoleic acid emulsion at 30 μg/mL concentration. BHA, BHT, α-tocopherol and trolox exhibited inhibitions of 89.88, 89.97, 83.82 and 91.85% against peroxidation of linoleic acid emulsion at the same concentration, respectively. In addition, pyrogallol was an effective of all the scavenging and reducing power results. In this study, pyrogallol was also evaluated as potential inhibitor for acethycholinesterse enzyme. The results showed that pyrogallol exhibited potent acetylcholinesteras inhibitory activity with IC50 and Ki values 10.2 and 8.6 μM, respectively.
AtıfScopus71WoS62OpenAlex76İncele - MakaleAçık Erişim2015Scopus SJRQ3Synthesis and biological evaluation of a new series of 4-alkoxy-2-arylquinoline derivatives as potential antituberculosis agents
Tosun, Gonca; Arslan, Tayfun; Iskefiyeli, Zeynep; Küçük, Murat; Karaoʇlu, Şengül Alpay; Yayli, Nurettin
Three new series of 33 quinolone compounds, 2-(2-, 3-, and 4-fluorophenyl)-4-O-alkyl(C5-15)quinolines (7a-k, 8a-k, and 9a-k), were synthesized from 2-(2-, 3-, and 4-fluorophenyl)-2,3-dihydroquinolin-4(1H )-one (4, 5, and 6) by the reaction of alkyl halides under basic conditions in DMF. The new compounds 7a-k, 8a-k, and 9a-k were synthesized from flavonones 4-6, which can be considered new precursors for quinoline synthesis through a one-step reaction. All the target compounds (7a-k, 8a-k, and 9a-k) were evaluated for their in vitro antimicrobial activity against nine test microorganisms. They showed the most activity against Mycobacterium smegmatis with minimum inhibitory concentrations (MIC) of 62.5-500 μg/mL, indicating their potential uses as antituberculosis agents. Among them 8a-k (m-fluoride) were the most active compounds against M. smegmatis (MIC, 62.5-125 μg/mL). The newly synthesized title compounds were also evaluated for their in vitro antioxidant activities using DPPH• radical scavenging and FRAP tests. They showed at a low concentration (mg/mL) a range of SC50 values of 0.03-12.48 mg/mL (DPPH•) and 0-722 μM (FRAP), respectively. The antioxidant results of compounds 7a-k, 8a-k, and 9a-k revealed that the length of the alkyl chain was negatively correlated with antioxidant capacity.
AtıfScopus7WoS7OpenAlex11İncele - MakaleAçık Erişim2015Scopus SJRQ2Cytotoxic effect of Turkish propolis on liver, colon, breast, cervix and prostate cancer cell lines
Turan, Ibrahim; Demir, Selim; Misir, Sema; Kilinc, Kagan; Mentese, Ahmet; Aliyazicioglu, Yuksel; Deger, Orhan
Purpose: To investigate the total polyphenolic and flavonoid contents, antioxidant power and cytotoxic activity of ethanol extracts of Turkish propolis (EEP). Methods: The total polyphenolic and flavonoid contents of EEP were determined by spectrometric methods. Antioxidant power and cytotoxic activity of EEP were evaluated using ferric reducing antioxidant power (FRAP) and MTT assays, respectively. Results: The total polyphenolic and flavonoid contents, and FRAP value of EEP were 124.6 ± 1.5 mg gallic acid/g sample dry weight, 42.0 ± 0.8 mg quercetin/g sample dry weight and 311.0 ± 2.5 mg trolox/g sample dry weight, respectively. EEP exhibited powerful cytotoxic effects against the five human cancer cell lines. The highest cytotoxic activity of Turkish EEP was demonstrated on PC-3 cell line (IC50 = 20.7±3.4 μg/mL). Conclusion: The results demonstrate that EEP is a good source of antioxidant and a natural antitumor agent capable of reducing cancer cell proliferation.
AtıfScopus64WoS60OpenAlex71İncele - MakaleYalnız künye2015Scopus SJRQ1Preliminary assessment of a yoghurt-like product manufactured from hazelnut slurry: Study using response surface methodology
Ilyasoğlu, Huri; Yilmaz, Firat; Burnaz, Nesibe Arslan; Baltaci, Cemalettin
The aim of this study was to evaluate the possibility of using hazelnut slurry in manufacture of yoghurt. A yoghurt-like product was prepared from hazelnut slurry fortified with skimmed milk powder. The effects of the total solids content of the hazelnut slurry (TSCHS, 8-16g100g-1) and the content of milk powder (CMP, 6-9g100g-1) on the proximate composition, physicochemical and sensorial properties, fatty acid composition, total phenolic content (TPC) and antioxidant activity of the product were evaluated using response surface methodology. Both the TSCHS and the CMP had a significant effect on the total solids content, b value, syneresis, palmitic and oleic acid content, and FRAP value. Only the TSCHS showed a significant effect on the protein and fat content, a value, water-holding capacity, TPC and ABTS values. Only the CMP showed a significant effect on the carbohydrate and ash content and the acidity. The characteristics of the product generally appeared to be compatible with those of yoghurt. The product was rich in unsaturated fatty acids. Therefore, using hazelnut slurry in manufacture of yoghurt may be proposed to enhance the health benefits of yoghurt.
AtıfScopus24WoS22OpenAlex26İncele - MakaleAçık Erişim2015Scopus SJRQ1Synthesis and determination of some biological activities of novel 2,4-dinitrophenyl derivatives
Öztürk Sarikaya, Sevim B.; Kaya, Afşin A.; Kaya, Elif C¸elenk; Şentürk, Murat
The antioxidant and radical scavenging activities of the synthesized compounds 3, 5, and 6 were determined by various in vitro assays such as 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid radical (ABTS.+) scavenging, ferric ion (Fe3+) reducing power and ferrous ion (Fe2+) chelating activities. Moreover, these activities were compared to those of standard antioxidants such as butylated hydroxyanisole, butylated hydroxytoluene, and trolox. The results showed that the new compounds (3, 5, and 6) had potential antioxidant activity. Besides, inhibition of the two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I and II with some nitrobenzene compounds was investigated. Compounds 1-6 showed Ki values in the range of 4.88-193.4 μM and 5.295-54.75 μM for hCA I and hCA II, respectively.
AtıfScopus5WoS3OpenAlex4İncele - MakaleYalnız künye2014Scopus SJRQ3Antioxidant and antimicrobial activities of pomegranate (Punica granatum L.) sour sauce extracts
Yildiz, Hilal; Sengul, Memnune; Cetin, Bulent; Karatas, Neva; Ercisli, Sezai; Okcu, Zuhal; Dzubur, Ahmed; Hadziabulic, Semina
In this study, nine-pomegranate sour sauce (PSS) obtained from market in Turkey was tested for their total phenolic content (TPC), antioxidant and antimicrobial activity and selected physico-chemical properties. Methanolwater extracts of PSS were found more effective than water extracts against microorganisms. In particular, Pseudomonas pseudoalkaligenes BC3445 and Staphylococcus aureus ATCC 29213 showed the greatest sensitivity to the extracts. Total soluble solids, total sugar, reducing sugar, sucrose, ash, pH, titratable acidity, colour (L, a, b) of PSS were determined between 69.5-73.3° Brix, 21.89-53.44 g/100 g, 20.97-50.62 g/100 g, 0.75-2.81 g/100 g, 0.05-0.58 g/100g, 2.64-2.91, 4.30-7.97, 16.58-55.38, (+3.94)-(+38.54), (-6.98)-(-38.36). β-carotene bleaching assay indicated that PSS possessed considerable antioxidantactivities. The higher antioxidant capacities of PSS implied that they might be potential resources for the development of functional food.
AtıfScopus1İncele - MakaleYalnız künye2014Scopus SJRQ3An investigatio n of the antioxidant activities and some physicochemical characteristics of strawberr y added yogurt
Engül, M.S.; Erkaya, T.; Yildiz, H.
The effect of adding strawberry pulp to yogurt on its physicochemical properties, antioxidant activity and sensory characteristics was studied. For this purpose, experimental yogurts were produced by the addition of strawberry pulp (at 8, 12 and 16%) to plain yogurt and analyses were carried out through 14 days of cold storage. The titratable acidity and viscosity values of yogurts increased with the increasing of strawberry pulp concentration. Conversely, the total solid, fat, protein, ash, pH and syneresis values decreased. Antioxidant activity (β-caroten bleaching assay) and IC50 (DPPH radical scavenging assay) in yogurts ranged from 77.71 to 86.12%, 205.70 to 2241.09 μg /mL during storage, respectively. For the sensory properties of yogurts, yogurt including 16% of strawberry pulp received the highest overall acceptability score on the first day of storage.
AtıfScopus10WoS8İncele - MakaleAçık Erişim2014Scopus SJRQ1The effect of cooking on total polyphenolic content and antioxidant activity of selected vegetables
Şengül, Memnune; Yildiz, Hilal; Kavaz, Arzu
The aim of this study to investigate the effect of different cooking methods (boiling, steaming, stir-frying, and microwaving) on the total polyphenolic content and total antioxidant activity of selected vegetables (beet, red cabbage, broccoli, white cabbage, black radish, kale, turnip, and red radish) from Turkey. A wide variation on total phenolic content was observed in raw vegetables, ranging from 44.94 ± 0.47 (beet, Beta vulgaris L. subsp. vulgaris) to 350.94 ± 5.18 (red radish, Raphanus sativus L.) μg gallic acid equivalent/mg of sample. Considering uncooked vegetables, the order of total antioxidant activity determined by β-carotene bleaching assay was beet > red cabbage > broccoli > white cabbage > black radish > kale > turnip > red radish. In DPPH• assay, kale had an exceptionally high antioxidant activity followed by red cabbage, broccoli, turnip, black radish, beet, white cabbage, and red radish.
AtıfScopus58WoS50OpenAlex66İncele - MakaleYalnız künye2013Scopus SJRQ2Radical scavenging and antioxidant capacity of serotonin
Sarikaya, S. Beyza Öztürk; Gülçin, Ilhami
Serotonin is a monoamine neurotransmitter and biochemically derived from tryptophan. The present paper examines the in vitro antioxidant and radical scavenging capacity of serotonin using different in vitro methodologies. For the determination of antioxidant activity of serotonin, 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH) scavenging, 2,2́-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging activity, total antioxidant activity determination by ferric thiocyanate, total reducing ability determination by Fe3+-Fe2+ transformation method, superoxide anion radical scavenging by riboflavin-methionine-illuminate system, H2O2 scavenging and ferrous ions (Fe +) chelating activities of serotonin were performed. Also, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), α-tocopherol and trolox, a water-soluble analog of α-tocopherol, were used as the reference antioxidant radical scavenger compounds. Serotonin completely inhibited lipid peroxidation of a linoleic acid emulsion at 15 μg/mL concentration. On the other hand, the above mentioned standard antioxidants displayed inhibition of 92.2, 99.6, 84.6 and 95.6% on peroxidation of linoleic acid emulsion, respectively at the 45 μg/mL concentration. In addition, serotonin was effective in DPPH· scavenging, ABTS•+ radical scavenging, superoxide anion radical scavenging, H2O2 scavenging, ferric ions (Fe3+) reducing power and metal chelating on ferrous ions (Fe+) activities. Also, those various antioxidant activities were compared to BHA, BHT α-tocopherol and trolox as references antioxidant compounds.
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