Gümüşhane ÜniversitesiGümüşhane ÜniversitesiAçık Erişim Arşivi · RDL Open

Synthesis and determination of some biological activities of novel 2,4-dinitrophenyl derivatives

MakaleAçık Erişim
  • SDG 3 · Sağlık ve Kaliteli Yaşam

Özet

The antioxidant and radical scavenging activities of the synthesized compounds 3, 5, and 6 were determined by various in vitro assays such as 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid radical (ABTS.+) scavenging, ferric ion (Fe3+) reducing power and ferrous ion (Fe2+) chelating activities. Moreover, these activities were compared to those of standard antioxidants such as butylated hydroxyanisole, butylated hydroxytoluene, and trolox. The results showed that the new compounds (3, 5, and 6) had potential antioxidant activity. Besides, inhibition of the two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I and II with some nitrobenzene compounds was investigated. Compounds 1-6 showed Ki values in the range of 4.88-193.4 μM and 5.295-54.75 μM for hCA I and hCA II, respectively.

Anahtar Kelimeler

Antioxidant activityCarbonic anhydraseEnzyme inhibitorNitrobenzene
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/gumushane/13172Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.1002/ardp.201400330Yayıncı resmi DOI adresi
Tam Kayıt
AlanDeğerDil
dc.contributor.authorÖztürk Sarikaya, Sevim B.
dc.contributor.authorKaya, Afşin A.
dc.contributor.authorKaya, Elif C¸elenk
dc.contributor.authorŞentürk, Murat
dc.date.accessioned2026-10-22T10:21:01.092448742Z
dc.date.available2026-10-22T10:21:01.092448742Z
dc.date.issued2015
dc.description.abstractThe antioxidant and radical scavenging activities of the synthesized compounds 3, 5, and 6 were determined by various in vitro assays such as 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid radical (ABTS.+) scavenging, ferric ion (Fe3+) reducing power and ferrous ion (Fe2+) chelating activities. Moreover, these activities were compared to those of standard antioxidants such as butylated hydroxyanisole, butylated hydroxytoluene, and trolox. The results showed that the new compounds (3, 5, and 6) had potential antioxidant activity. Besides, inhibition of the two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I and II with some nitrobenzene compounds was investigated. Compounds 1-6 showed Ki values in the range of 4.88-193.4 μM and 5.295-54.75 μM for hCA I and hCA II, respectively.
dc.description.sponsorshipGumushane University (BAP) [13.B0110.02.1]
dc.identifier.doi10.1002/ardp.201400330
dc.identifier.eissn1521-4184
dc.identifier.endpage220
dc.identifier.issn0365-6233
dc.identifier.issue3
dc.identifier.pmid25644396
dc.identifier.scopus2-s2.0-84923833870
dc.identifier.startpage214
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/gumushane/13172
dc.identifier.volume348
dc.identifier.wosWOS:000350502100006
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.relation.ispartofArchiv der Pharmazie
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant activity
dc.subjectCarbonic anhydrase
dc.subjectEnzyme inhibitor
dc.subjectNitrobenzene
dc.subject.classificationChemistry, Medicinal
dc.subject.classificationChemistry, Multidisciplinary
dc.subject.classificationPharmacology & Pharmacy
dc.subject.classificationChemistry
dc.subject.otherAntioxidants
dc.subject.otherCarbonic Anhydrase I
dc.subject.otherCarbonic Anhydrase II
dc.subject.otherCarbonic Anhydrase Inhibitors
dc.subject.otherDinitrobenzenes
dc.subject.otherDrug Design
dc.subject.otherHumans
dc.subject.otherMolecular Structure
dc.subject.otherStructure-Activity Relationship
dc.subject.other(2,4 dinitrophenyl)[[4 (prop 1 en 2 yl)cyclohex 1 enyl]methyl]sulfane
dc.subject.other2,4 dinitrophenol
dc.subject.otheracetazolamide
dc.subject.otherbutylated hydroxyanisole
dc.subject.otherbutylcresol
dc.subject.othercarbonate dehydratase I
dc.subject.othercarbonate dehydratase II
dc.subject.otherferrous ion
dc.subject.othernitrobenzene derivative
dc.subject.otherresveratrol
dc.subject.othertrolox C
dc.subject.otherunclassified drug
dc.subject.other[(2 chloro 7,7 dimethylbicyclo[2.2.1]heptan 1 yl)methyl] (2,4 dinitrophenyl)sulfane
dc.subject.other[(6,6 dimethylbicyclo[3.1.1]hept 2 en 2 yl)methyl] (2,4 dinitrophenyl)sulfane
dc.subject.otherantioxidant
dc.subject.othercarbonate dehydratase inhibitor
dc.subject.otherABTS radical scavenging assay
dc.subject.otherantioxidant activity
dc.subject.otherArticle
dc.subject.otherbiological activity
dc.subject.othercarbon nuclear magnetic resonance
dc.subject.otherchelation
dc.subject.othercolumn chromatography
dc.subject.othercompetitive inhibition
dc.subject.otherdrug determination
dc.subject.otherdrug synthesis
dc.subject.otherenzyme activity
dc.subject.othererythrocyte
dc.subject.otherhuman
dc.subject.otherhuman cell
dc.subject.otherpriority journal
dc.subject.otherproton nuclear magnetic resonance
dc.subject.otherstructure activity relation
dc.subject.otherantagonists and inhibitors
dc.subject.otherchemical structure
dc.subject.othercomparative study
dc.subject.othermetabolism
dc.subject.othersynthesis
dc.titleSynthesis and determination of some biological activities of novel 2,4-dinitrophenyl derivatives
dc.typeArticle
dspace.entity.typePublication
rdl.citation.openalex4
rdl.citation.scopus5
rdl.citation.wos3
rdl.departmentEngineering and Natural Sciences Faculty, Food Engineering Department, Gumushane University, Gumushane, Turkey
rdl.oa.statusgreen
rdl.oa.statuspreprint
rdl.oa.urlhttps://hdl.handle.net/20.500.12501/1053
rdl.sdgSDG03
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)
rdl.wos.indexIndex Chemicus (IC)