Yazarlar
- Uzun, Sevda(79)
- Kulakaç, Nurşen(40)
- Turan, Ibrahim(33)
- Demir, Selim(32)
- Türkkan, Tuğba(24)
- Aydin, Aydanur(23)
- Topal, Fevzi(22)
- Aliyazicioglu, Yuksel(21)
- Tuncer, Metin(21)
- Bayrakdaroglu, Serdar(19)
- Demirağ, Hatice(19)
- Hintistan, Sevilay(18)
- Topal, Meryem(18)
- Yılmaz, Coşkun(18)
- Bayrakdaroğlu, Serdar(15)
- Yilmaz, Coskun(15)
- Mentese, Ahmet(14)
- Reis, Hatice Catal(14)
- Demir Doğan, Melike(13)
- Emirza, Elif Güzide(13)
- Memetoglu, Mehmet Erdem(13)
- Tuncer, Gülsüm Zekiye(13)
- Bülbül, Kenan(12)
- Cin, Aynur(12)
- Düzgün, Azer Özad(12)
- Koçak, Tevfik(12)
- Odaci, Hatice(12)
- Oğuzhan, Hatice(12)
- Tonkaz, Duygu Erkal(12)
- Tonkaz, Mehmet(12)
- Turk, Veysel(12)
- Ceylan, Halil Ibrahim(11)
- Kilinc, Kagan(11)
- Köse, Aslı(11)
- Merdan, Mehmet(11)
- Acet, Tuba(10)
- Aksoy, Bahar(10)
- Aydin Sayilan, Aylin(10)
- Baltaci, Cemalettin(10)
- Deger, Orhan(10)
Yayınlar
- MakaleYalnız künye2023Scopus SJRQ1Psychometric validation of the Persian version of optimism scale in university students
Saeighi Mameghani, Shiva; Yilmaz, Müge; Balcı Çelik, Seher; Karimi, Kambiz
Right now, more than ever in our lives, we need to remain optimistic. The present study aimed to examine the validity and reliability of The Optimism Scale, developed by Balcı & Yılmaz (2002), among Iranian university students and to adapt to Iranian culture. The scale is a single-factor scale with 24 items. The participants were selected using an appropriate sampling method, and the sample consisted of 600 Iranian university students (360 females and 240 males) from Tehran and Tabriz cities. Participants’ age ranged from 18 to 24 years (M = 21.58, SD = 1.75). The study findings suggested similarities between Iran and Turkey culture (e.g., religion, language, neighborhood relations). The optimism scale revealed a good construct validity in the Goodness of fit index indicators. The Cronbach alpha internal consistency coefficient for the scale was 0.76 and Convergent validity with happiness was 0.38. In future studies, the scale’s factor structure can be investigated in different samples, such as adolescents and adults.
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İncele - MakaleAçık Erişim2023Scopus SJRQ1Multi-criteria evaluation of medical waste management process under intuitionistic fuzzy environment: A case study on hospitals in Turkey
Çelik, Sefa; Peker, İskender; Gök-Kısa, A. Cansu; Büyüközkan, Gülçin
Waste management has come to the fore in the whole world with the increasing impact of the Covid-19 pandemic along with concerns about human health, environmental threats, and socio-economic factors, etc. Medical waste is one of the waste types that need special management processes including particularly collection, storage, separation, and disposal. Healthcare activities create a great amount of medical waste deriving from the hospitals. This study aims to determine the hospital that carries out medical waste management in the most effective way in Erzurum, Turkey. To handle intense uncertainty in the evaluation process, the case is analyzed by Intuitionistic Fuzzy Multi-Criteria Decision-Making (IFMCDM) methods. The present study contributes to the literature by focusing on a real case problem under IF environment in a Group Decision-Making (GDM) framework. Additionally, based on the literature review and expert judgments, the evaluation criteria relevant to the case are defined in this paper. To this end, a four-phased integrated methodology that involves Intuitionistic Fuzzy Weighted Averaging (IFWA), IF Analytical Hierarchy Process (IFAHP), IF Technique for Order Preference by Similarity to Ideal Solution (IFTOPSIS) and One-Dimensional Sensitivity Analysis, is conducted. Firstly, IFWA is aimed to express the significance levels of decision makers (DMs) based on their knowledge, qualifications and experiences. Secondly, IFAHP is used to calculate the importance weights of the decision criteria and IFTOPSIS is preferred to rank the available hospitals. Then, sensitivity analysis is employed to display robustness. According to the results, the most important criteria are Qualified personnel, Health institution infrastructure, and Control of waste, respectively and the most efficient hospital is determined.
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İncele - MakaleAçık Erişim2023Scopus SJRQ1Attitudes of parents in the role of a father in Turkey toward child sex education and their sexual communication with their children
Apaydin Cirik, Vildan; Aksoy, Bahar; Bulut, Elif
Background and purpose: The study aimed to evaluate the attitudes of parents in the role of a father in Turkey toward child sex education and their sexual communication with their children. Methods: This descriptive and cross-sectional study was conducted with the fathers of children in the pediatric outpatient clinic at a state hospital between December 30, 2021, and April 15, 2022. The study was reported based on STROBE. The data were collected from 297 fathers using the Descriptive Information Form, the Attitudes Scale Toward Sex education (ASTSE), and the Sexual Communication Scale for Parents(SCSP). Results: Sample statistics demonstrate that 67.7% of the participants did not receive sex education in their childhood, and 57.4% stated that their children received sex education only from their mothers. Higher attitudes toward sexual education were found in the fathers with a university or higher education degree (χ2 = 15.396; p < 0.01), and those giving sex education to their children (χ2 = 18.388;p < 0.001). Higher total scores were obtained on the sexual communication scale by fathers with university and higher education degrees (χ2 = 12.898;p < 0.01) and those who received sex education in their childhood (t = 2.330;p = 0.021). There is a highly significant positive correlation between the mean scores of the role of a parent subscale of the ASTSE and the mean total score of the SCSP (r = 0.81;p < 0.001). Conclusions: There is a positive correlation between fathers' parental role attitudes toward sex education and their sexual communication with their children. Practice implications: Supporting fathers' sexual communication with their children can positively affect fathers' attitudes and communication toward sex education.
AtıfScopus14WoS11OpenAlex16İncele - MakaleYalnız künye2023Scopus SJRQ1Increased heat tolerance and transcriptome analysis of Salmonella enterica Enteritidis PT 30 heat-shocked at 42 ℃
Qiu, Yan; Ozturk, Samet; Cui, Xinyao; Qin, Wen; Wu, Qingping; Liu, Shuxiang
In this study, we compared the heat tolerance parameter (D65℃) values of Salmonella enterica serovar Enteritidis PT 30 (S. Enteritidis ) heat adapted at different degrees (at 42 ℃ for 20–180 min) and cultivated using two methods. The treated group with the highest D65℃ value (LP-42 ℃-60 min) and the untreated groups (Control-TSB and Control-TSA) were subjected to transcriptome analysis. Heat-adaptation increased the D65℃ values of S. Enteritidis by 24.5–60.8%. The D65℃ values of the LP-42 ℃-60 min group (1.85 ± 0.13 min, 7.7% higher) was comparable to that of the Control-TSA. A total of 483 up- and 443 downregulated genes of S. enteritidis were identified in the LP-42 ℃-60 min group (log2fold change > 1, adjusted p-value < 0.05). Among these genes, 5 co-expressed and 15 differentially expressed genes in the LP-42 ℃-60 min and Control-TSA grops possibly contributed to the high D65℃ values of S. Enteritidis. The Rpo regulon was involved in the heat adaptation of S. Enteritidis, as evidenced by the significant upregulation of rpoS, rpoN, and rpoE. KEGG enrichment pathways, such as biosynthesis of secondary metabolites, tricarboxylic acid, and ribosomes were identified and mapped to reveal the molecular mechanisms of S. enteritidis during heat adaptation. This study quantified the enhanced heat tolerance of S. Enteritidis heat adapted at different degrees of heat-adaptation. The results of this study may serve as a basis for elucidating the molecular mechanisms underlying the enhanced heat tolerance at the transcriptome level.
AtıfScopus9WoS9OpenAlex10İncele - MakaleAçık Erişim2023Detection of COVID-19 infection from CT images using the medical photogrammetry technique
Çatal Reis, Hatice; Türk, Veysel; Kaya, Serhat
Medical data such as computed tomography (CT), magnetic resonance imaging (MRI), and Ultrasound images are used in medical photogrammetry. CT images have been used frequently in recent years for the diagnosis of COVID-19 disease, which has contagious and fatal symptoms. CT is an effective method for early detection of lung anomalies due to COVID-19 infection. Machine learning (ML) techniques can be used to detect and diagnose medical diseases. In particular, classification methods are applied for disease diagnosis and diagnosis. This study proposes traditional machine learning algorithms Random Forest, Logistic Regression, K-Nearest Neighbor and Naive Bayes, and an ensemble learning model to detect COVID-19 anomalies using CT images. According to the experimental findings, the proposed ensemble learning model produced an accuracy of 96.71%. This study can help identify the fastest and most accurate algorithm that predicts CT images with Covid-19 during the epidemic process. In addition, machine learning-based approaches can support healthcare professionals and radiologists in the diagnostic phase.
- MakaleAçık Erişim2023Scopus SJRQ3The Distinguishing Factor in Soccer Players is Aerobic Performance, not the ACTN3 Gene; [El Factor Distintivo en los Jugadores de Fútbol es el Rendimiento Aeróbico y no el gen ACTN3]
Zileli, Raif; Söyler, Mehmet; Diker, Gürkan; Özkamçı, Hüseyin; Bayrakdaroglu, Serdar; Sever, Mehmet Onur; Can, Ibrahim; Ön, Sadi; Aslan, Beste Tacal; Ulucan, Korkut
SUMMARY: The purpose of this study was to reveal the differences between ACTN3 genotype (RR, RX, XX) and aerobic performance [Yo-Yo IRT1 (m), VO2 max (ml/kg/min)] in professional and regional amateur league soccer players and to reveal which of these parameters was a distinctive factor in these athletes.71 professional soccer players (age: 23.66 ±4.11 years; body height: 1.79 ± 6.99 m; body weight: 76.02 ± 6.76 kg; body fat: 11.59±3.11 %) and 62 regional amateur soccer players (age: 23.63 ±3.77 years; body height: 1.81 ± 5.77 m; body weight: 76.36 ± 7.53 kg; body fat: 15.60±4.65 %) volunteered for the study. After DNA extraction from buccal epithelial cells via a commercial kit was performed for the genetic background of the athletes, Real-Time PCR was carried out for genotyping. Furthermore, Yo-Yo IRT1 test was performed to determine the aerobic performance of the soccer players. SPSS 23 (SPSS Inc., Chicago, IL, USA) package program was used for the statistical analysis of the data obtained in the tests. Shapiro-Wilk test for normality and Levene's test for homogeneity of variance were performed. Chi-Square, Independent Sample T Test and One Way ANOVA test were used in the analysis of the parameters. Statistical significance was set as p<0.05. In the study, there found no meaningful statistical significance in terms of the rs1815739 polymorphism in the ACTN3 gene between the groups (p>0.05); however, there was a statistical significance in favor of professional soccer players in terms of aerobic parameters (p<0.05). Consequently, it can be said that aerobic performance is the distinguishing factor, not the ACTN3 gene, in soccer players.
AtıfScopus3OpenAlex2İncele - MakaleYalnız künye2023Scopus SJRQ3Determination of the Antioxidant Capacity of Puerarin and Its Effect on Cholinesterases by in vitro and in silico Methods
İnan Ergün, Aslı; Topal, Meryem
Puerarin, which was used as a natural isoflavone in this study, was obtained from the Kudzu plant. The inhibitory effect of puerarin on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes was investigated. The IC50 values of AChE (177.73 nM) and BChE (315.07 nM) were determined. The binding mechanism of puerarin, which has a high inhibitory effect on the active site of the enzyme, was demonstrated by the molecular docking method. The antioxidant activity was evaluated for the same molecule. For this purpose, Fe3+-Fe2+ reducing capacity, ABTS radical scavenging activity, CUPRAC method, DPPH⋅ scavenging activity and DMPD radical scavenging method were used. The percentage (%) inhibition amount of puerarin molecule was calculated as 99.33 % for ABTS radical scavenging activity, which is the more preferred method for natural products. The absorbtion value of iron reduction of Puerarin was 0.122±0.010, and the value of copper reduction was 0.633±0.026. Our research efforts include uncovering the potent antioxidant potential of puerarin and, simultaneously, a comparative study of tacrine, primarily emphasizing its inhibitory effects against AChE and BChE enzymes. The puerarin is expected to be a guide for drug discovery against many problems, especially oxidative cell damage in Alzheimer's disease, mitochondrial dysfunction (MD), cancer, and cardiovascular diseases.
AtıfScopus11WoS5OpenAlex9İncele - MakaleAçık Erişim2023Scopus SJRQ2Detection of virulence factor genes, antibiotic resistance genes and biofilm formation in clinical Gram-negative bacteria and first report from Türkiye of K.oxytoca carrying both bla OXA-23 and bla OXA-51 genes
Özad Düzgün, Azer; Yüksel, Gamze
The Gram-negative bacteria were isolated from various samples and antibiotic susceptibility testing were performed. The strains were screened by PCR for class 1 integron, virulence and antibiotic resistance genes. blaOXA-23 and blaOXA-51 genes positive samples were cloned into the pGEM-T vector and the plasmids were sent for DNA sequence analysis. The isolates were showed resistance to quinolone, cephalosporin, aminoglycoside, carbapenem and penicillin group antibiotics. Virulence factor genes were identified in 121 strain. The most common virulence gene was determined to be aer (29.78%), followed by sfa (28.19%), afa (27.12%), cnf (21.27%), pap (12.76%) and hly (12.76%). In addition, 34 different virulence patterns were observed. Plasmid-mediated quinolone resistance genes were detected 15 of67 quinolone-resistant isolates. Among carbapenem resistant strains, blaOXA-23 gene was detected in 16 and blaOXA-51 gene in 19 isolates. The strains producing OXA-23 and OXA-51 were Klebsiella oxytoca, Acinetobacter baumannii, E.coli and P.mirabilis. In this study, clinical isolate K. oxytoca carrying both blaOXA-23 and blaOXA-51 genes were identified first time from Türkiye. A high predominance (88.82%) of class 1 integron was detected. In addition, determined that 46.27% of the isolates had the ability to form biofilms. In conclusion since the limited treatment options of antibiotic-resistant Gram-negative pathogens that cause serious infections are an important problem in terms of public health it is important to investigate antibiotic resistance, virulence factor genes and biofilm formation in these pathogens.
AtıfScopus4WoS3OpenAlex4İncele - BildiriYalnız künye2023An Efficient 1D Autoencoder-Based Approach for R-Peaks Detection in Electrocardiogram Signals
Dogan, Ramazan Ozgur; Dogan, Hulya; Kayikcioglu, Temel
Electrocardiogram (ECG) signal which is composition of multiple segments such as P-wave, QRS complex and T-wave plays a crucial role in evaluating human heart cardiac diagnosis. For an analysis of cardiac diagnosis, it is required that clinicians scan the ECG signal for R-peaks (the highest peak of the QRS complex) detection, which relies on their expertise and takes enormous time. In order to provide more realistic treatment of cardiovascular diseases in the ECG signal with noises and different characteristics, computer-based R-peaks detection approaches have been actively developed in the research article for many years and generally compose of two major operations; preprocessing and decision. Contrary to previous approaches which require high computational costs and complexity, appropriate initial parameters, a novel CNN based approach is presented for R-peaks detection in this paper. Both qualitative and quantitative analysis are performed in the real ECG signal taken from typical MIT-BIH arrhythmia database. In order to validate the success of the recommended approach, total 18 different R-peaks detection approaches reported in the literature are compared by utilizing performance evaluation metrics. Average values of sensitivity, positive predictivity, error rate, accuracy and f-score are computed as 99,96%, 99,95%, 0,09%, 99,90% and 99,95% respectively, which are the best values among well-established studies for R-peaks detection. It is demonstrated with qualitative and quantitative results that better performance is achieved by our suggested approach.
AtıfScopus2OpenAlex2İncele - MakaleYalnız künye2023Scopus SJRQ2Worry about Climate Change of Outdoor Recreation Participants: A Case Study in Türkiye
Aslan, Ramazan; Köçer, Musab Süleyman; Mizrak, And Sefa
Anthropogenic climate change (ACC) is considered to be one of the biggest threats to humanity in this century, with severe direct or indirect impacts on people’s lives. Such a significant threat causes serious concern, which can motivate low-level proenvironmental behavior and lead to serious health problems at high levels. Therefore, determining the level of this concern is crucial. Outdoor recreation participants, who are constantly in contact with nature, can closely witness the effects of ACC due to these interactions. Therefore, evaluating their ACC worry is essential. In this study, the aim was to determine the ACC worry levels of outdoor recreation participants. The research data were collected through an online survey from a sample reached through convenience sampling method throughout Türkiye. The data were analyzed using analysis of moment structures (AMOS) and Statistical Package for the Social Sciences (SPSS) software. The relationship between independent variables and ACC concern was revealed through ordinal logistic regression. The research found that the participants had a high level of concern about ACC, with a score of 3.50. It was also determined that this level of concern was influenced by variables such as the type of outdoor recreation, the duration of participation in outdoor recreation, and exposure to the effects of ACC. Considering that ACC can motivate proenvironmental behaviors, the research suggests that outdoor recreational participants with high levels of concern about ACC should not be ignored in the adaptation process.
AtıfScopus4WoS4OpenAlex5İncele - MakaleAçık Erişim2023Scopus SJRQ2Mobile care app development process: using the ADDIE model to manage symptoms after breast cancer surgery (step 1)
Aydin, Aydanur; Gürsoy, Ayla; Karal, Hasan
The use of mobile applications is widespread in patient monitoring or education today. This study aims to describe the design and development process of a mobile app that supports patient self-care after breast cancer surgery. We used the ADDIE model to develop and test the mobile app. ADDIE (Analysis, Design, Development, Implementation, Evaluation) is a systematic approach based on a standard instructional design model for creating training materials. The model consists of five phases, each with its own set of steps. Once the steps within each phase are completed, the model progresses to the next phase, ultimately resulting in a “usable” product. Different team collaborations were established within each phase, and support was obtained from multiple experts during the design process. Thanks to this model, the information that patients need was transformed into a technological product. This article, which explains the stages of the product design process for mobile applications, provides information that may be helpful to researchers working on similar products.
AtıfScopus34WoS28OpenAlex36İncele - MakaleYalnız künye2023Scopus SJRQ1Microwave decontamination processing of tahini and process design considerations using a computational approach
Topcam, Huseyin; Coskun, Eda; Son, Ezgi; Kutuk, Dilay; Aytac, S. Aykut; Mert, Behic; Ozturk, Samet; Erdogdu, Ferruh
Tahini, as a low moisture food product, is linked to several outbreaks of Salmonella recently even though a high temperature roasting (of sesame seeds) through its production is involved. Therefore, a final decontamination approach might be required for safety. Considering its higher oil content and lower thermophysical properties, conventional approaches are not easy to apply while preserving the quality attributes. Therefore, microwave heating was used for decontamination purpose. For this purpose, a computational mathematical model was developed first to determine the temperature distribution of tahini during microwave heating, and microbial inactivation studies for Salmonella enteritidis (ATCC 13076) were carried out. Changes in color and peroxide values were evaluated, and the experimentally validated model was further used to design an industrial process to achieve a 5-log cycle reduction as an efficient decontamination processing. The target temperature over 80 °C within the sample was demonstrated to achieve such a process, and industrial scale process conditions were presented for 262 kg/h process capacity.
AtıfScopus9WoS7OpenAlex10İncele - MakaleAçık Erişim2023Scopus SJRQ1Effect of individual characteristics, risk perception, self-efficacy and social support on willingness to relocate due to floods and landslides
Mızrak, Sefa; Turan, Melikşah
People may have to leave their home, environment, region and country because of disasters or disaster risks. Effective and efficient disaster risk reduction activities involving the community can reduce disaster risks and enable people to reside more safely and peacefully in their environment. The objective of this study was to investigate whether individual characteristics, risk perception, self-efficacy and perceived social support were correlated with the willingness to relocate due to floods and landslides. The data were collected from 947 people residing in Gümüşhane Province (Türkiye) using a survey. In the study, a total of ten models were tested with the help of ordinal logistic regression analysis. Consequently, the participants' willingness to relocate due to landslides was determined to be higher than the willingness to relocate due to floods. University students and people with chronic diseases and flood and landslide experiences had a greater willingness to relocate. Residence duration and informal social support were negatively correlated with relocation willingness. Those who believed that they could protect themselves in the event of a flood and landslide were more likely to relocate. Among risk perceptions, probability increased relocation willingness mostly due to floods, while fear increased relocation willingness mostly due to landslides. This study attempted to provide policy makers and scientists insight into disaster risk reduction and disaster risk communication related to relocation.
AtıfScopus37WoS32OpenAlex43İncele - MakaleAçık Erişim2023Scopus SJRQ1Evaluation of moral sensitivity and moral courage in intensive care nurses in Turkey during the COVID-19 pandemic
Goktas, Sonay; Aktug, Cemile; Gezginci, Elif
Background: During the COVID-19 pandemic, intensive care nurses may experience ethical issues related to fear of transmission, limited resources, and increased workload. Nurses' moral sensitivity and courage may have a role in dealing with these problems. Aim: The purpose of this study was to assess intensive care nurses' moral sensitivity and moral courage during the COVID-19 pandemic. Design: Descriptive cross-sectional survey. Methods: A total of 362 nurses working in the intensive care units of pandemic hospitals in Turkey participated in the study between January and March 2021. Data were obtained using a personal information form, the Moral Sensitivity Questionnaire, and the Nurses' Moral Courage Scale. A link to the online data collection tools was sent to the management of participating institutions, who forwarded it to nurses. Reporting followed the CHERRIES guidelines. Results: In this study, the response rate of nurses was 89%. The nurses' total mean moral sensitivity score was 90.70 ± 28.89 and their mean moral courage score was 82.08 ± 13.51. A weak inverse correlation was found between the nurses' moral sensitivity and moral courage scores (r = −.176, p =.001). Total moral sensitivity score differed significantly according to years of Intensive care unit (ICU) experience (p =.007). Total moral courage scores increased significantly with education level (p =.012), years of nursing experience (p =.016), and willingness to work in the ICU (p <.001). Conclusion: The study suggests that nurses working in the intensive care unit during the pandemic had moderate moral sensitivity and high levels of moral courage. Nurses' sociodemographic characteristics and ICU work conditions may affect their moral sensitivity and moral courage. Relevance to Clinical Practice: The results of this study can help guide efforts to improve moral courage and sensitivity and address ethical issues among ICU nurses.
AtıfScopus42WoS37OpenAlex46İncele - MakaleYayıncıda açık erişim2023Scopus SJRQ1DEVELOPMENT OF THE THIRST DISCOMFORT SCALE: A VALIDITY AND RELIABILITY STUDY
Çiftçi, Bahar; Yıldız, Güzel Nur; Avşar, Gülçin; Köse, Sema; Aydın, Esra; Doǧan, Sevgi; Çelik, Şeymanur
Background Thirst is a sensation associated with a dry mouth and the desire or craving to drink water. Surgical patients are among those hospitalized individuals who are at high risk of developing both osmotic and hypovo-lemic thirst. Objectives To develop a new measurement tool for evaluating the thirst-related discomfort of surgical patients and to assess its validity and reliability. Methods The study population consisted of patients admitted to the surgical clinics of a research hospital in Turkey between January and March 2022. The new measurement tool was developed in several stages: a pilot implementation phase with 51 patients and the main implementation phase with 198 patients. Data were col-lected by means of face-to-face interviews with patients. Exploratory factor and confirmatory factor analyses were performed using IBM SPSS Statistics, version 22, and IBM SPSS Amos. Results The final Thirst Discomfort Scale consisted of 12 items in 3 subdimensions. The Cronbach α values of the scale subdimensions ranged from 0.787 to 0.848, and the Cronbach α value for the scale as a whole was 0.886. The scale explained 66.237% of the total variance of the data. Conclusion The Thirst Discomfort Scale consisting of 12 items and 3 subdimensions is a valid and reliable measurement tool for evaluating thirst-related discomfort of surgical patients.
AtıfScopus8WoS10OpenAlex11İncele - MakaleYalnız künye2023Scopus SJRQ1Immunogenic evaluation of multi-epitope peptide-loaded PCPP microparticles as a vaccine candidate against Toxoplasma Gondii
Yilmaz-Ozturk, Rabia; Calik, Hilal; Yaman, Serkan; Ustun-Karatop, Eslin; Cakir-Koc, Rabia
Toxoplasmosis is a major health problem and socioeconomic burden, affecting around 30–50% of the global population. Poly(dicarboxylatophenoxy)phosphazene (PCPP) polymer was chosen as adjuvant for the immunogenic peptide antigen. Peptide-loaded PCPP microparticles were synthesized via the coacervation method and the characterization studies of microparticles were conducted to determine their size, charge, morphology, encapsulation efficacy, and loading capacity. To evaluate in vivo efficacy of the vaccine candidate, Balb/c mice were immunized with the formulations. Brain and spleen tissues were isolated from animals to investigate cytokine levels, lymphocyte proliferation, and brain cyst formation. As a result, antibody and cytokine responses in groups immunized with peptide-loaded PCPP microparticles were found to be significantly higher when compared to the control group. In conclusion, our novel multi-epitope peptide-loaded PCPP microparticle-based vaccine formulation demonstrated considerable humoral and cellular immune responses against T. gondii and protected mice against T. gondii infection during Toxoplasmosis.
AtıfScopus3WoS2OpenAlex3İncele - MakaleAçık Erişim2023Scopus SJRQ4Hypoglycaemia after Initiation of CFTR Modulator Therapy in a Cystic Fibrosis Patient without Diabetes
Yskout, Marie; Vliebergh, Joke; Bor, Hakan; Dupont, Lieven; Lorent, Natalie; Van Bleyenbergh, Pascal; Gillard, Pieter; Van Der Schueren, Bart; Mertens, Ann; Mathieu, Chantal
Introduction. Cystic fibrosis transmembrane regulator (CFTR) modulator therapies improve respiratory function and glycaemic control in patients with cystic fibrosis (CF). The direct effect of CFTR modulator therapies on pancreatic function in patients without preexisting diabetes remains unclear. Case Presentation. An 18-year-old female with CF caused by F508del/F508del mutation, who had no diabetes, developed postprandial hypoglycaemias 6 months after initiation of elexacaftor, tezacaftor, and ivacaftor combination therapy (ETI). Symptoms were persisted after brief discontinuation of ETI, but her symptoms and time-in-hypoglycaemia had improved remarkably by avoiding high glycaemic index-foods. Discussion. This case of hypoglycaemia associated with CFTR modulator therapy in a patient without preexisting diabetes suggests that CFTR modulator therapy has the potential to directly affect glucose homeostasis. There might be an improvement in insulin secretion as well as a reduction in systemic insulin resistance. Conclusion. Treatment of CF patients without diabetes with CFTR modulator therapies can cause recurrent hypoglycaemic episodes which resolve with dietary measures.
AtıfScopus2WoS2OpenAlex1İncele - MakaleAçık Erişim2023Determining Levels of Search and Rescue Team’s Knowledge on Avalanche Search and Rescue
Kaya, Nahsan; Atalay, Ezgi; Demir Doğan, Melike
Avalanches kill more than 150 people every year, although no one knows the exact figure. Additionally, the mortality rate in avalanche incidents may reach up to 70% due to factors such as the lack of knowledge, experience, and organization of search and rescue personnel. This cross-sectional study was conducted to determine the awareness on avalanche and the level of knowledge on search and rescue among personnel who respond to avalanche incidents and participate in search and rescue activities. The sample consisted of 304 individuals who agreed to participate in the study between June and July 2021. Data were collected using an information form on socio-demographic characteristics and a survey prepared by the researchers upon the relevant literature review. It was found that while 65.8% of the participants were female, 34.2% were male. Their mean age was 29.69±8.50 years. The rate of those participating in search and rescue activities in case of a disaster was 44.1 %. The participants had a moderate level of knowledge on avalanche search and rescue as well as on-site medical management of avalanche victims. Those who participated in search and rescue activities in case of a disaster had a higher level of knowledge on avalanche search and rescue than those who did not. Those who were trained on avalanche search and rescue (preparedness, response) had higher levels of knowledge on avalanche search and rescue and on-site medical management of avalanche victims when compared to those who were not. As a consequence, it was determined that participation in search and rescue activities in a disaster increased the personnel’s level knowledge. Also, the related training elevated the levels of knowledge on both avalanche search and rescue and on-site medical management of avalanche victims.
AtıfScopus1
İncele - MakaleYayıncıda açık erişim2023Scopus SJRQ1MediNet: transfer learning approach with MediNet medical visual database
Reis, Hatice Catal; Turk, Veysel; Khoshelham, Kourosh; Kaya, Serhat
The rapid development of machine learning has increased interest in the use of deep learning methods in medical research. Deep learning in the medical field is used in disease detection and classification problems in the clinical decision-making process. Large amounts of labeled datasets are often required to train deep neural networks; however, in the medical field, the lack of a sufficient number of images in datasets and the difficulties encountered during data collection are among the main problems. In this study, we propose MediNet, a new 10-class visual dataset consisting of Rontgen (X-ray), Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Ultrasound, and Histopathological images such as calcaneal normal, calcaneal tumor, colon benign colon adenocarcinoma, brain normal, brain tumor, breast benign, breast malignant, chest normal, chest pneumonia. AlexNet, VGG19-BN, Inception V3, DenseNet 121, ResNet 101, EfficientNet B0, Nested-LSTM + CNN, and proposed RdiNet deep learning algorithms are used in the transfer learning for pre-training and classification application. Transfer learning aims to apply previously learned knowledge in a new task. Seven algorithms were trained with the MediNet dataset, and the models obtained from these algorithms, namely feature vectors, were recorded. Pre-training models were used for classification studies on chest X-ray images, diabetic retinopathy, and Covid-19 datasets with the transfer learning technique. In performance measurement, an accuracy of 94.84% was obtained in the traditional classification study for the InceptionV3 model in the classification study performed on the Chest X-Ray Images dataset, and the accuracy was increased 98.71% after the transfer learning technique was applied. In the Covid-19 dataset, the classification success of the DenseNet121 model before pre-trained was 88%, while the performance after the transfer application with MediNet was 92%. In the Diabetic retinopathy dataset, the classification success of the Nested-LSTM + CNN model before pre-trained was 79.35%, while the classification success was 81.52% after the transfer application with MediNet. The comparison of results obtained from experimental studies observed that the proposed method produced more successful results. Graphical abstract: [Figure not available: see fulltext.]
AtıfScopus16WoS14OpenAlex18İncele - MakaleYalnız künye2023Scopus SJRQ1The Association Between Personal, Affective, and Cognitive Factors and Suicide Risk Among Muslims in Turkey
Yazıcı Çelebi, Gülin; Kaya, Feridun
This study was conducted to examine the association of various personal, affective, and cognitive factors with suicide risk. The study group consisted of a total of 423 individuals, including 341 (74%) females and 82 (26%) males, who lived in Turkey and declared that they were Muslims. The data of the study, in which a cross-sectional design was employed, were collected between October and December 2022. The mean age of the participants was 26.84 years (SD = 9.88, min–max = 18–64). The data collection measures included the Psychological Distress Scale, the Perception of God Scale, the Two-Dimensional Self-Esteem Scale, the Suicide Probability Scale, and a personal information form. Pearson correlation analysis and Hierarchical Multiple Linear Regression analysis were employed in the analysis of the data obtained from the research. In the study, it was found that gender, age, suicide attempt, communication with the mother, communication with the father, psychological distress, self-esteem, and perception of God explained 58% of the variance in suicide risk. Psychological distress had the strongest positive association with suicide risk (β = 0.136, p < 0.001), while self-esteem had the strongest negative relation (β = − 0.454, p < 0.001). In conclusion, it was determined that the female gender, suicide attempt, and psychological distress increased the risk of suicide, but that age, positive communication with parents, self-esteem, and positive perception of God decreased it. The findings of the research were discussed in light of the literature.
AtıfScopus2WoS2OpenAlex4İncele
