Yazarlar
- Uzun, Sevda(79)
- Kulakaç, Nurşen(40)
- Turan, Ibrahim(33)
- Demir, Selim(32)
- Türkkan, Tuğba(24)
- Aydin, Aydanur(23)
- Topal, Fevzi(22)
- Aliyazicioglu, Yuksel(21)
- Tuncer, Metin(21)
- Bayrakdaroglu, Serdar(19)
- Demirağ, Hatice(19)
- Hintistan, Sevilay(18)
- Topal, Meryem(18)
- Yılmaz, Coşkun(18)
- Bayrakdaroğlu, Serdar(15)
- Yilmaz, Coskun(15)
- Mentese, Ahmet(14)
- Reis, Hatice Catal(14)
- Demir Doğan, Melike(13)
- Emirza, Elif Güzide(13)
- Memetoglu, Mehmet Erdem(13)
- Tuncer, Gülsüm Zekiye(13)
- Bülbül, Kenan(12)
- Cin, Aynur(12)
- Düzgün, Azer Özad(12)
- Koçak, Tevfik(12)
- Odaci, Hatice(12)
- Oğuzhan, Hatice(12)
- Tonkaz, Duygu Erkal(12)
- Tonkaz, Mehmet(12)
- Turk, Veysel(12)
- Ceylan, Halil Ibrahim(11)
- Kilinc, Kagan(11)
- Köse, Aslı(11)
- Merdan, Mehmet(11)
- Acet, Tuba(10)
- Aksoy, Bahar(10)
- Aydin Sayilan, Aylin(10)
- Baltaci, Cemalettin(10)
- Deger, Orhan(10)
Yayınlar
- MakaleAçık Erişim2023Scopus SJRQ1Leveraging blockchain in response to a pandemic through disaster risk management: an IF-MCDM framework
Peker, Iskender; Ar, Ilker Murat; Erol, Ismail; Searcy, Cory
The COVID-19 pandemic has underscored the necessity for strategic approaches to manage global catastrophes. This study argues that disaster risk management (DRM) is an essential approach to mitigate the impact of global calamities, such as a pandemic. However, due to the uncertainty emerging from variables such as time and demand, managing DRM effectively involves high complexity. Blockchain technology (BcT) can be implemented to help address these challenges due to its potential to build trust, transparency, and accountability in complex operations. However, no research has quantitatively examined the applicability of BcT in the sub-dimensions of DRM to address the COVID-19 pandemic. The goal and scope of this study is to explore the role of BcT in DRM operations during the COVID-19 pandemic through an Intuitionistic Fuzzy Multi-Criteria Decision Making (IF-MCDM) framework. More specifically, the Intuitionistic Fuzzy Analytic Network Process (IF-ANP) method was utilized to calculate the weights of key criteria (i.e., BcT benefits), while Intuitionistic Fuzzy VIKOR (IF-VIKOR) was used to prioritize the alternatives (i.e., the sub-dimensions of DRM). The findings of this study are threefold. First, supporting effective coordination turned out to be the most essential benefit of BcT to build resilience in response to the COVID-19 pandemic. Second, disaster management was found to be the most appropriate DRM sub-dimension for possible BcT implementation during the COVID-19 pandemic. Lastly, eleven distinct activities involved in disaster management and governance and financial protection were discovered to be the most applicable for BcT. The findings of this study could assist disaster risk managers to assess whether (or not) BcT is suitable for the sub-dimensions of DRM to build national and organizational resilience in the wake of the COVID-19 pandemic.
AtıfScopus27WoS22OpenAlex34
İncele - MakaleAçık Erişim2023Scopus SJRQ1The psychological dimension of menopause: a phenomenological study: Being menopause in Turkey: a qualitative study
Uzun, Sevda; Ozcan, Handan; Jones, Duygu
This study aims to determine the perceptions of women in menopause living in Turkey regarding this period and associated problems, which has shown that some women are negatively affected by the menopause period and have difficulty coping with the effects of menopause. The study has a basic qualitative research design, and the sample was determined by using the criterion sampling method, one of the purposeful sampling methods. The effects and characteristics of menopause themes are included in the category of perception of menopause among women, and the themes of positive and negative perspectives are included in the category of perspective on menopause. It is reported that women experience feelings of fear, uncertainty, irritability, anxiety/worry, introversion, relaxation, and happiness during menopause. Our study has shown that some women are negatively affected by the menopause period and have difficulty coping with the effects of menopause.
AtıfScopus4WoS6OpenAlex6İncele - MakaleAçık Erişim2023First report of qnr and blaVIM-4-like producing clinical Alcaligenes faecalis isolated in Türkiye; [Türkiye'den izole edilen qnr ve blaVIM-4-like üreten klinik Alcaligenes faecalis’in ilk raporu]
Akyildiz, Esma; Saral Sariyer, Ayşegül; Köse, Tuba; Arslan, Mikail; Beriş, Fatih Şaban; Özad Düzgün, Azer
The study set out to look at the clinical strain of A. faecalis's antibiotic susceptibility pattern. Both biochemical and molecular approaches were used to identify A.faecalis. The VITEK compact system was used to analyze the strain's antibiotic susceptibility profile. The use of PCR was evaluated to determine the presence of resistance genes. It was also determined whether resistance determinants could be transferred. It was determined that A. feacalis showed resistance to imipenem, cefepime, ceftazidime, gentamicin, amikacin, netilmicin, tobramicin, ciprofloxacin, and levofloxacin. The blaVIM-4-like gene was present in this strain, according to the results of the PCR and DNA sequencing studies. In contrast to VIM-4, this blaVIM-4-like gene showed one amino acid change (Ala265Val).Filter-mating experiments showed that the blaVIM-4-like gene cannot be transferred from A. faecalis to E. coli. In this study, This research, demonstrated the presence of the blaVIM-4-like gene for the first time in A. faecalis from Turkey.
- MakaleYalnız künye2023Scopus SJRQ1The Effect of Burnout and Moral Sensitivity Levels of Surgical Unit Nurses on Job Satisfaction
Kulakaç, Nurşen; Uzun, Sevda
Purpose: This study was carried out to determine the effect of burnout and moral sensitivity levels of surgical unit nurses on their job satisfaction. Design: A descriptive and correlational design study. Methods: The population consisted of 268 nurses working in health institutions in the Eastern Black Sea Region of Turkey. The data were collected online between 1 and 30 April, 2022 using a sociodemographic data form, the Maslach Burnout Inventory, the Minnesota Job Satisfaction Scale, and the Moral Sensitivity Scale. Pearson correlation analysis and logistic regression analysis were used to evaluate the data. Findings: The nurses' moral sensitivity scale mean score was 105.2 ± 18.8, and the Minnesota job satisfaction scale mean score was 3.3 ± 0.7. The participants' mean emotional exhaustion score was 25.4 ± 7.3, the depersonalization score average was 15.7 ± 4.6, and the personal accomplishment mean score was 20.5 ± 6.7. The factors affecting the job satisfaction of nurses were found to be moral sensitivity, personal accomplishment, and satisfaction with the unit they worked. Conclusions: Nurses had high levels of burnout due to emotional exhaustion, one of the subdimensions of burnout, and moderate levels of burnout due to depersonalization and personal accomplishment. The moral sensitivity and job satisfaction of nurses are moderate. As the nurses' accomplishment and ethical sensitivity levels increased and their emotional exhaustion levels decreased, their job satisfaction levels increased.
AtıfScopus11WoS9OpenAlex16
İncele - MakaleAçık Erişim2023Scopus SJRQ1Breast cancer-related apps in Google Play and App store: evaluate their functionality and quality
Aydin, Aydanur; Gursoy, Ayla
Aim: This study aimed to evaluate the functionality and quality of breast cancer apps that can be accessed from Turkey. Methods: In this study, a systematic search strategy was used to identify free mobile apps on breast cancer available in the App and Google Play stores. According to the study’s PRISMA flowchart, 707 apps met the inclusion criteria. The Mobile App Rating Scale (MARS) assessed the quality of the apps. Results: Mobile apps focused on the categories of communication, education, and treatment order/plan. The mean MARS quality score for all apps was 3.4, and according to the mean score of the subscales, they were categorized as functionality, aesthetics, information quality, and participation. In addition, the mean scores of the subscales were listed on MARS as functionality, aesthetics, knowledge quality, and participation. Conclusion: Nowadays, “e-health” apps are attracting attention in the treatment of health problems. While the apps in download stores appear to provide basic information about breast cancer, they offer limited and personalized problem management related to prevention, early detection, and screening. Support from healthcare professionals and further efforts can be made to develop innovative technologies and apps that include evidence-based informational content about breast cancer. Implications for Cancer Survivors: In the process of breast cancer information, survivors can be encouraged to manage this process using e-health services.
AtıfScopus6WoS6OpenAlex13İncele - Derleme MakaleYalnız künye2023Scopus SJRQ1A Comprehensive Review of Computer-based Techniques for R-Peaks/QRS Complex Detection in ECG Signal
Dogan, Hulya; Dogan, Ramazan Ozgur
Electrocardiogram (ECG) signal, which is composite of multiple segments such as P-wave, QRS complex and T-wave, plays a crucial role in the treatment of cardiovascular disease. For an analysis of cardiac diagnosis, it is required that clinicians scan the ECG signal for QRS complex or R-peaks (the highest peak of the QRS complex) detection, which relies on their expertise and takes enormous time. In order to provide more realistic treatment of cardiovascular diseases, so many computer-based techniques detecting R-peaks/QRS complex in the ECG signal with noises and different characteristics have been actively developed in research article for many years. Moreover, researchers have created various data sets for R-peaks/QRS complex detection. Although R-peaks/QRS complex detection is one of the notable research areas with so many computer-based techniques and ECG data sets, no comprehensive review paper have been published recently. The main aim of this study is to present a wide range of computer-based techniques proposed for detection of R-peaks/QRS complex. First of all, in this study, computer-based techniques proposed in the literature for the detection of R-peaks/QRS complex and their stages are introduced in detail. The generalization ability of these techniques is investigated deeply. Details are given about the most preferred ECG data sets produced in the literature for the analysis of computer-based techniques. Finally, the performances of computer-based techniques and generalization abilities are analyzed for each data set created in the literature by giving the results of the evaluation metrics.
AtıfScopus30WoS21OpenAlex30İncele - MakaleAçık Erişim2023Scopus SJRQ4The Effect of a Musical Toy on Preschool Children’s Pain and Anxiety During Blood Collection; [Okul Öncesi Dönem Çocuklarında Kan Alma İşlemi Sırasında Işıklı Dönen Müzikli Oyuncağın Ağrı ve Anksiyeteye Etkisi]
Kurudirek, Fatma; Demir İmamoğlu, Zeynep; Ekici, Sümeyye
Objective: This study examined the effect of providing a lighted, rotating musical toy on preschool children’s pain and anxiety during a blood collection procedure. Methods: The randomized controlled study was conducted on a sample of children aged 4-6 years who applied to the blood collection unit of a state hospital in Turkey from July 1 through August 1, 2022. The data were obtained from 95 children who met the research criteria (48 in the control group and 47 in the intervention group). Stratification and block randomization methods were used to determine the experimental and control groups. The variables of gender and fear of interference were used in the stratification of the children. The Family and Child Information Form, Child Fear and Anxiety Inventory, and Wong–Baker Facial Expression Rating Scale were used to collect the data. Results: The pain scores of the children in the experimental group were found to be lower (1.42 ± 1.05) than those in the control group (2.81 ± 1.23), and the result was statistically significant (P < .001). During the procedure, the mean Child Fear and Anxiety Inventory score of the children in the experimental group (1.21 ± 0.97) was lower than that of the control group (2.72 ± 1.10), and the difference was statistically significant (P < .001). Conclusion: This study found that providing a lighted, rotating musical toy to children aged 4-6 during blood collection effectively reduced their pain and anxiety. In line with these results, it is recommended that nurses and parents use such a toy in blood collection units to reduce pain and anxiety in children.
AtıfScopus4WoS3OpenAlex2TR Dizin1
İncele - MakaleYayıncıda açık erişim2023Scopus SJRQ4Postoperative symptom management perceptions and coping experiences of individuals with prostate cancer
Kazımoğlu, Hatem; Ulutaşdemir, Nilgün; Kulakaç, Nurşen; Uzun, Sevda
Objective: This study aims to examine in depth the perceptions of postoperative symptom management and coping experiences of individuals with prostate cancer. Material-Method: The study was conducted with 15 individuals with prostate cancer using a phenomenological research design, which is a qualitative research design. Interviews were conducted via the WhatsApp application. Results: The data were analysed using Colaizzi's phenomenological method. In the data analysis, two categories, five main themes, and 15 sub-themes emerged. In the category of symptom management perception, there are themes of pain management processes, the use of complementary and alternative therapies and practices to cope with symptoms and improve quality of life. In the category of coping experiences, the themes of individual coping, interpersonal relations, and productivity were obtained. Conclusion: Our study suggests that individuals with prostate cancer have difficulty in symptom management in the postoperative coping process, but they managed them effectively with the support of their spouse, family, and health care professionals.
AtıfScopus1WoS1OpenAlex1İncele - MakaleYalnız künye2023Scopus SJRQ2LC-HRMS Profiling and Phenolic Content, Cholinesterase, and Antioxidant Activities of Terminalia citrina
Özler, Ebubekir; Topal, Fevzi; Topal, Meryem; Öztürk Sarıkaya, Sevim Beyza
Terminalia citrina (T. citrina) belongs to the Combretaceae family and is included in the class of medicinal plants in tropical countries such as Bangladesh, Myanmar, and India. The antioxidant activities of lyophilized water (WTE) and alcohol extracts (ETE) of T. citrina fruits, their phenolic content by LC-HRMS, and their effects on cholinesterases (ChEs; AChE, acetylcholinesterase, and BChE, butyrylcholinesterase) were investigated. Especially ten different analytical methods were applied to determine the antioxidant capacity. Compared with similar studies for natural products in the literature, it was determined that both WTE and ETE exhibited strong antioxidant capacity. Syringe and ellagic acids were higher than other acids in ETE and WTE. IC50 values for ETE and WTE in DPPH radical and ABTS⋅+ scavenging activities were calculated as 1.69–1.68 μg mL−1 and 6.79–5.78 μg mL−1, respectively. The results of the biological investigations showed that ETE and WTE had an inhibition effect against ChEs, with IC50 values of 94.87 and 130.90 mg mL−1 for AChE and 262.55 and 279.70 mg mL−1 for BChE, respectively. These findings indicate that with the prominence of herbal treatments, T. citrina plant may guide the literature in treating Alzheimer's Disease, preventing oxidative damage, and mitochondrial dysfunction.
AtıfScopus13WoS8OpenAlex14İncele - MakaleAçık Erişim2023Scopus SJRQ3Agreement Between Nurses’ Anxiety And Depression Levels And Their Compliance With Isolation Measures During The Covid 19 Pandemic: An Online Cross-Sectional Study
Demir Doğan, Melike; Aydin Sayilan, Aylin; Sayilan, Samet
Aims: The purpose of this study was to determine the relationship between nurses’ anxiety and depression levels and their compliance with isolation measures during the COVID-19 pandemic. Background: The global COVID-19 pandemic has had severe psychological impacts on nurses. Methods: Following receipt of the requisite approvals, data were collected actively from 289 nurses consenting to participate in the study through an online questionnaire using theinternet/ social media. Results: Mean stress, anxiety, and depression scores were higher among carers for COVID-19 patients than in non-Covidcarers. Analysis revealed significant positive correlation between Isolation Precautions Compliance Scale scores and stress, anxiety, depression, and burnout. Conclusion: Burnout increased while compliance with isolation precautions decreased in this study as stress, anxiety, and depression increased.
AtıfScopus12WoS9OpenAlex5İncele - MakaleYalnız künye2023Scopus SJRQ2Endemic Mountain Tea (Sideritis dichotoma Huter): Antioxidant and Antibacterial Activities, Mineral Content by ICP-MS and Phytochemical Content by LCHR-MS
Öztürk Sarıkaya, Sevim Beyza; Zehiroğlu, Cuma
Endemic Sideritis dichotoma Huter, herbal tea, is used for colds, coughs and digestive ailments. Since at least 25 % of the active ingredients of pharmacological drugs are obtained from plants, it is important to investigate many plants, both traditionally used and whose potential hasnt yet been discovered, before they disappear. When the results compared to other Sideritis species, it has better antioxidant activity in DPPH⋅ scavenging activity, Fe3+ and Cu2+ reducing capacity methods and is also rich in minerals, necessary for human body, K, Mg, Ca, P, S. Zone values (10–19,5 mm) obtained on S. aureus, P. aeruginosa, E. coli, S.enteritidis, E. faecalis, P. putida and K. pnemoniae strains are an indication that the plant has antibacterial activity. 27 secondary metabolites were identified by LC-HRMS. Verbascoside, pharmacologically active compound known to have antitumor effect, cytotoxic selectivity and anticancer activity, is the most abundant phenolic in ethanol extract (49297.13 mg/kg).
AtıfScopus7WoS6OpenAlex8İncele - Kitap BölümüYalnız künye2023Grains and Pulses in Diets of the Middle East and a Focus on Buckwheat
Yılmaz, Hacı Ömer; Meriç, Çağdaş Salih
Buckwheat (Fagopyrum esculentum Moench and Fagopyrum tataricum (L.) Gaertn.) is believed to have originated in central Asia. Chiefly cultivated in India, Nepal, China, North Korea, Russia, and Japan, it is a pseudocereal containing high protein, dietary fiber, vitamins and minerals, polyunsaturated fatty acids, and important antioxidants and phenolic compounds. In addition to its high protein bioavailability and economic value, it is an important alternative food with high nutritional value, suitable for the diet of celiac patients because it does not contain gluten. Buckwheat has gained worldwide importance because of the presence of some important bioactive constituents such as rutin, orientin, vitexin, quercetin, isovitexin, and isoorientin; other essential components like fagopyritols find vast potential for glycemic control in type 2 diabetics, positive cardiovascular effects, treatment of celiac disease, prevention of gallstones, and several hormone-dependent tumors. Currently, various products of buckwheat like flour, bread, biscuits, cookies, muffins, cakes, pasta, noodles, crackers, chips, and various fermented products and desserts are available in the market. Buckwheat has attracted worldwide attention, especially from food scientists, for its healing effects over chronic diseases. This chapter focuses on buckwheat in diets of the Middle East and its important effects on health.
AtıfScopus2OpenAlex2İncele - MakaleAçık Erişim2023Scopus SJRQ1Identification of the drivers of and barriers to COVID-19 vaccine intake behavior using a mixed-method design: implications from a developing country
Kordestani, Arash; Oghazi, Pejvak; Izmir, Onur; Oypan, Oguz; Ozer, Serhat
Various COVID-19 vaccines are available across the world. However, short phases of clinical trials for emergency use and myriad rumors about and misinformation on vaccines spread through different media sources, induce confusion and trigger vaccine hesitancy behavior. Although clinical trials demonstrated promising results in the ability of vaccines to protect, social endeavor is required for vaccines to succeed. Mitigation of the pandemic is only possible through widespread acceptance of the vaccine. Thus, identifying the factors that impact vaccine intake is crucial. This study determined factors that affect intentions toward vaccination using a mixed-method approach, in which qualitative and quantitative analyses were conducted together. Analysis of variance (ANOVA) is used in the quantitative study, and content analysis is employed in the qualitative study. The final sample of this mixed-method study consists of 568 participants for the quantitative study and 237 for the qualitative study. They were selected using an online questionnaire. Findings suggest that social, psychological, attitudinal, perceptual, and informational factors play a crucial role in shaping people's intentions toward vaccines, ultimately influencing their decision to accept or reject vaccination. Results of both the qualitative and quantitative studies, in parallel with each other, indicated similar barriers against and drivers toward vaccine intake behavior, providing strong insights into the reasons behind vaccine acceptance and hesitancy. Based on the insights gained in this study, a set of recommendations were compiled for policymakers.
AtıfScopus10WoS9OpenAlex11İncele - MakaleAçık Erişim2023Scopus SJRQ4The Effect of Different Physical Education Class Hours Applied in Secondary Education on Certain Physiological and Physical Parameters
Sever, Mehmet Onur; Söyler, Mehmet; Çingöz, Yunus Emre; Barkin, Emrah
This study investigates the effects of different physical education lesson hours applied to secondary school students on some physical and physiological parameters. A total of 36 secondary school students voluntarily participated in the study: respectively, 18 from Group 1 and 18 from Group 2 (age: 14.94±0.41 / 14±0.34 years; height: 175.22±7.62 / 169.33±6.95 cm; weight: 61.95±9.07 / 56.83±6.33 kg). While Group 1 students received 8 hours of physical education lessons per week, Group 2 students were given 2 hours of physical education lessons according to the Ministry of National Education curriculum. Body weight (kg) and body fat percentage (%) were determined using the Inbody 270 professional body analysis device. A portable dynamic balance device was used to determine the students' balance. The test results were analyzed using the SPSS Statistics software. Non-parametric tests were employed since the data did not show a normal distribution. The Mann-Whitney U test was used to test the significance of the difference in balance and body fat percentage (BFP) level averages between the two independent groups. Upon evaluating our data, it was statistically ascertained that the dynamic balance (Balance) values of Group 1 secondary school students were significantly higher when compared to Group 2 students. However, no statistically significant difference was found in body fat percentage (BFP) values between Group 1 and Group 2. As a result, it is seen that increasing physical education lesson hours in secondary education contributes to some physical development of young individuals.
- Derleme MakaleAçık Erişim2023Scopus SJRQ1“Who am I?” A qualitative meta-synthesis of Chemotherapy‐induced alopecia and body image perception in breast cancer patients
Kocan, Sema; Aktug, Cemile; Gursoy, Ayla
Background: Since alopecia may be the first physical evidence and sign of cancer diagnosis and treatment, it may have a more serious and challenging effect on a woman than the loss of breast tissue. Objective: The purpose of this study was to summarize the current qualitative research which explores the body image perceptions of breast cancer patients with chemotherapy-induced alopecia. Material and methods: We searched three electronic databases and reviewed studies from December 2011 to December 2021 for qualitative results analysing the experiences of women with breast cancer and chemotherapy-induced alopecia. The Joanna Briggs Institute critical (JBI) appraisal tool was used to assess the quality of the targeted studies. The Meta-synthesis process developed by Sandelowski and Barroso was used to collect and analyse the data. Results: We discovered two main and five sub-themes from the meta-synthesis findings of 11 qualitative studies involving 225 women. The main themes were “I am not comfortable in this body” and “Who am I?”. The first main theme revealed patients’ intense reactions to their hair loss: “I'm in emotional chaos”, “I am looking for a place to hide” and “I knew it and now I’m experiencing it”.The second main theme of “Who am I?” contained two sub-themes: “What did my hair take from my femininity when it was gone?” and “Will I lose my partner after my hair?”. Conclusion: Meta-synthesis provided an up-to-date and integrated interpretation of scientific results about the experiences of women with breast cancer, alopecia, and their body image perceptions. This interpretation will facilitate a more comprehensive understanding of the alopecia-body image relationship. Thus, the aim of the meta-synthesis results is that these will contribute to nurses’ understanding of how alopecia, although a temporary symptom, affects women's perceptions of body image.
AtıfScopus27WoS24OpenAlex23İncele - MakaleAçık Erişim2023Scopus SJRQ2Vaccination status of COVID-19 patients followed up in the ICU in a country with heterologous vaccination policy: A multicenter national study in Turkey
Yildirim, Suleyman; Erkoyun, Erdem; Alpdog, Ozcan; Yilmaz, Huseyin Oguz; Yilmaz, Baris; Dönmez, Gul Erdal; Saritas, Aykut; Gökmen, Necati; Ergan, Begum; Bayrak, Vecihe
Objective: Vaccination against severe acute respiratory syndrome coronavirus-2 (SARS-2) prevents the development of serious diseases has been shown in many studies. However, the effect of vaccination on outcomes in COVID-19 patients requiring intensive care is not clear.Methods: This is a retrospective multicenter study conducted in 17 intensive care unit (ICU) in Turkey between January 1, 2021, and December 31, 2021. Patients aged 18 years and older who were diagnosed with COVID-19 and followed in ICU were included in the study. Patients who have never been vaccinated and patients who have been vaccinated with a single dose were considered unvaccinated. Logistic regression models were fit for the two outcomes (28-day mortality and in-hospital mortality).Results: A total of 2968 patients were included final analysis. The most of patients followed in the ICU during the study period were unvaccinated (58.5%). Vaccinated patients were older, had higher Charlson comorbidity index (CCI), and had higher APACHE-2 scores than unvaccinated patients. Risk for 28-day mortality and in-hospital mortality was similar in across the year both vaccinated and unvaccinated patients. However, risk for in-hospital mortality and 28-day mortality was higher in the unvaccinated patients in quarter 4 adjusted for gender and CCI (OR: 1.45, 95% CI: 1.06-1.99 and OR: 1.42, 95% CI: 1.03-1.96, respectively) compared to the vaccinated group.Conclusion: Despite effective vaccination, fully vaccinated patients may be admitted to ICU because of disease severity. Unvaccinated patients were younger and had fewer comorbid conditions. Unvaccinated patients have an increased risk of 28-day mortality when adjusted for gender and CCI.
AtıfWoS2OpenAlex3İncele - MakaleAçık Erişim2023Scopus SJRQ3Relationship of progranulin response with some physio-biochemical parameters in Akkaraman sheep
Bayraktar, Buelent; Tekce, Emre; Genç, Murat; Kaya, Hacer; Özcan, Gulbahar Boyuk; Aydemir, Seyma; Kotan, Goksad Cemil; Takma, Cigdem; Ürüsan, Hilal; Aksakal, Vecihi
Progranulin (PGRN) is a multifunctional protein that is critical in the retention of embryos in the endometrium of the uterus and the protection of cervical tissue during fetal growth. In case of PGRN release and dysfunction, cervical tissue may remodel (regeneration) and lead to the risk of abortion. Serum PGRN level in sheep and its variation according to different physiological periods and its relationship with some biochemical parameters are unknown. In this study, the relationship between early lactation, early and late pregnancy serum PGRN levels and some biochemical parameters in Akkaraman sheep was investigated for the first time. In the literature search, no similar studies were found on the relationship between early lactation, early and late pregnancy serum PGRN levels and some biochemical parameters in Akkaraman sheep. The research was carried out on 90 Akkaraman sheep reared in the same herd under the same care and feeding conditions. In the study, Akkaraman ewe were divided into 3 groups as early lactation, early pregnancy and late pregnancy. 1st group is early lactation period ewe (first 60 days of lactation), (n = 30), 2nd group is in the first period of pregnancy (on the 0-90th day of the first pregnancy (n = 30)), 3rd group is in the late pregnancy of pregnancy (100-150 days of pregnancy (n = 30)) was created. Blood samples from vena jugularis were taken before morning feeding from the animals that formed the study groups. PGRN levels in serum were determined by ELISA method. In addition, glucose, calcium (Ca), magnesium (Mg), phosphorus (P), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), very low density lipoprotein (VLDL) levels were analyzed in biochemistry autoanalyzer. As a result of the study, lactation and early pregnancy and late pregnancy mean serum PGRN levels were determined as 1.93, 1.78, 1.33 ng mL-1, respectively. The serum PGRN, glucose, Ca, Mg, P, TC, TG, LDL, HDL and VLDL levels of sheep with late pregnancy, early lactation and early pregnancy periods, which constitute the study groups, were found to be statistically significant (P<0.05). Our results have shown that due to the physiological role of PRGN in keeping the embryo in the endometrium of the uterine and in preserving the cervical tissue during fetal growth, there may be a useful parameter in the pursuit of the pregnancy process.
AtıfScopus4WoS4OpenAlex3İncele - MakaleAçık Erişim2023Scopus SJRQ1Determining the coronavirus awareness of the Turkish society and the anxiety stress levels
Aydin, Aydanur; Aktug, Cemile; Koçan, Sema; Erkaya, Reyhan; Yasak, Kubra; Cengiz, Burcu; Çalik, Kiymet Yesilcicek; Güler, Sevil; Erden, Sevilay; Karabulutlu, Ozlem
The aim of the study is to determine the awareness of the Turkish society in COVID-19, and determine the anxiety stress levels. Research two months after the start of the outbreak in Turkey has reached 2163 individuals completed the online platform. The Integrated Anxiety Stress Scale significantly changed according to age, gender, marital status and working status after the pandemic. According to the results of multiple binary logistic regression analysis, individuals aged 50 and over, female gender, being single and not working after the pandemic for anxiety; female gender, being married, and post-pandemic study were found to be risk factors for Covid awareness. It is recommended that epidemic awareness studies and information sharing on controlled healing measures are planned considering the anxiety levels.
AtıfScopus2WoS2OpenAlex3İncele - MakaleAçık Erişim2023Scopus SJRQ1An Investigation of the Protective Effect of Rhododendron luteum Extract on Cisplatin-Induced DNA Damage and Nephrotoxicity and Biochemical Parameters in Rats
Turan, Ibrahim; Canbolat, Deniz; Demir, Selim; Kerimoglu, Gokcen; Colak, Fatih; Alemdar, Nihal Turkmen; Mentese, Ahmet; Aliyazicioglu, Yuksel
The nephrotoxicity mechanisms caused by cisplatin (CP), which is used in the treatment of different types of cancer, include several processes, such as DNA damage, apoptosis, inflammation, and oxidative stress. This study investigated the protective effects of Rhododendron luteum leaf extract (RLE) in a rat model of CP -induced nephrotoxicity. Dimethyl sulfoxide extract of RLE was prepared, and its contents were clarified using liquid chromatography-mass spectrometry (LC-MS -MS). Thirty female Wistar Albino rats were divided into five different groups and sacrificed on the seventh day. Biochemical and histopathological analyses were then performed. The presence of quercitrin, quinic acid, chlorogenic acid, protocatechic acid, isoquercitrin, and quercetin was detected in the RLE. While CP significantly increased the levels of oxidative stress, inflammation, and apoptosis markers in the rat kidney tissue and blood samples, treatment with RLE significantly reversed the levels of these parameters in a dose-dependent manner. Total antioxidant status (TAS) values and glutathione (GSH) levels increased significantly in the serum samples from the treatment group compared to the CP group, while blood urea nitrogen (BUN), creatinine, oxidative stress index (OSI), tumor necrosis factor-alpha (TNF-alpha), malondialdehyde (MDA) and total oxidant status (TOS) values decreased significantly. GSH levels increased significantly in the treatment group compared to the CP group, while TNF-alpha, caspase-3 (Casp-3), 8-hydroxy-2'-deoxyguanosine (8-OHdG), OSI, TOS, MDA levels, and damage scores decreased significantly at histopathological examination. In conclusion, RLE exhibited strong protective effects against nephrotoxicity and oxidative damage caused by CP in rats.
AtıfScopus34WoS32OpenAlex25İncele - MakaleAçık Erişim2022Covid-19 Pandemi Sürecinin Sağlık Sektörü Çalışanları Üzerindeki Psikososyal Yansımaları: Nitel Bir Araştırma
Gökçe, Ahmet
2019 yılının Aralık ayında başlayarak günümüze kadar geçen sürede Covid-19 salgını dünya çapında milyonlarca insanı etkilemiş, ekonomik ve sosyal problemleri de beraberinde getirmiştir. Covid-19 salgını ile mücadelede ön hatlarda yer alan sağlık çalışanları ise bu süreçte üzerine en fazla yük düşen kesim olmuş, fiziksel ve ruhsal açıdan önemli ölçüde yıpranmışlardır. Bu noktadan hareketle, bu çalışmanın amacı, Covid-19 Pandemi sürecinin sağlık çalışanları üzerinde oluşturduğu psikososyal etkileri tespit etmektir. Bu amaçla, yarı yapılandırılmış görüşme yöntemi kullanılarak 25 sağlık çalışanı ile görüşme gerçekleştirilmiştir. Bu sağlık çalışanlarının 9’u doktor, 5’i hemşire, 5’i paramedik ,2’si ebe, 2’si tıbbi sekreter ve 2’si ise temizlik personeldir ebedir. Araştırma sonuçlarına göre psikososyal etkiler stres/depresyon/kaygı, tükenmişlik ve dışlanma olarak belirginlik kazanırken, çalışma ortamı ve koşullarının bu süreçte önemli bir etkiye sahip olduğu görülmüştür. Bu doğrultuda, Covid-19 döneminde çalışma ortamı ve koşullarının araştırmaya katılan sağlık çalışanlarını olumsuz etkileyerek onlarda stres ve kaygı bozukluklarına yol açtığı, depresyon belirtilerinin oluşmasına neden olduğu gözlemlenmiştir. Ayrıca sadece mesleklerinden dolayı araştırmaya katılan sağlık çalışanlarına yönelik olarak yoğun bir sosyal dışlanmanın olduğu tespit edilirken, tüm bu etkenlerin ise bireylerde tükenmişlik duygusuna yol açtığı belirlenmiştir.
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