Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(46)
- Kulakaç, Nurşen(21)
- Aydin, Aydanur(16)
- Demir, Selim(16)
- Tuncer, Metin(16)
- Topal, Fevzi(15)
- Turan, Ibrahim(15)
- Yilmaz, Coskun(14)
- Bayrakdaroglu, Serdar(12)
- Koçak, Tevfik(11)
- Aliyazicioglu, Yuksel(10)
- Gulcin, Ilhami(10)
- Ozturk, Samet(10)
- Topal, Meryem(10)
- Ceylan, Halil Ibrahim(9)
- Ceylan, Levent(9)
- Kilinc, Kagan(9)
- Mentese, Ahmet(9)
- Ozdes, Duygu(9)
- Tuncer, Gülsüm Zekiye(9)
- Duran, Celal(8)
- Emirza, Elif Güzide(8)
- Yaman, Serap Ozer(8)
- Yılmaz, Coşkun(8)
- Baltacı, Cemalettin(7)
- Demirağ, Hatice(7)
- Hintistan, Sevilay(7)
- Kaya, Feridun(7)
- Küçük, Murat(7)
- Ürkek, Bayram(7)
- Şengül, Mustafa(7)
- Bayrakdaroğlu, Serdar(6)
- Deger, Orhan(6)
- Genc, Berna(6)
- Gül, Abdulkadir(6)
- Gülçin, Ilhami(6)
- Günen, Mehmet Akif(6)
- Gürsoy, Ayla(6)
- Kurnaz, Muammer(6)
- Supuran, Claudiu T.(6)
Yayınlar
- Derleme MakaleYalnız künye2026Scopus SJRQ1Virtual reality as a non-pharmacological adjuvant for anxiety in oncology care: a systematic review and meta-analysis
Aydin, Aydanur; Bağcivan, Gülcan; Özkan, Aleyna
Background: Despite its growing presence in healthcare settings, research on the effectiveness of virtual reality (VR) interventions for symptom experience of patients with cancer remains varied and requires a comprehensive synthesis to reach definitive conclusions. Objective: This systematic review and meta-analysis aimed to assess the effectiveness of VR interventions in managing anxiety among individuals diagnosed with cancer. Methods: A comprehensive search of Ovid MEDLINE, PubMed, CINAHL, Web of Science, and Scopus databases was conducted for studies published from 2000 to November 2025. Publications were evaluated by independent reviewers for inclusion. The methodological quality of the included studies was assessed via Joanna Briggs Institute (JBI) critical appraisal tools for randomized controlled trials and quasi-experimental studies. Results: Twenty-one publications satisfied the requirements for review inclusion. The meta-analysis demonstrated that VR-based interventions were significantly effective in the management of patients’ anxiety, yielding a moderate-to-high effect size (SMD = −0.793, 95% CI = −1.403 to −0.184; Z = −2.551; p = 0.011). Most studies reported statistically significant decreases in anxiety scores across various cancer types, including breast, prostate, and ovarian cancers. No major side effects were reported, although minor instances of cyber sickness were managed by adjusting session durations. User satisfaction was exceptionally high, with satisfaction scores reaching 4.47/5 and 7.35/10. Implications for practice: The results support the use of VR as an effective and safe non-pharmacological intervention for anxiety management. The findings highlight the potential for VR to be integrated into routine oncology nursing and palliative care to improve the patient experience during stressful treatments like chemotherapy. Conclusion: VR-based interventions are an effective, safe, and highly acceptable approach for managing anxiety in patients with cancer. Further research is needed to support wider clinical implementation and to investigate the potential benefits of VR for other physical and psychological symptoms over longer follow-up periods. Trial registration: PROSPERO International Prospective Register of Systematic Reviews CRD42022351573.
- MakaleAçık Erişim2026Scopus SJRQ1Protecting the Privacy of Patients With Impaired Consciousness in Intensive Care: A Qualitative Study
Tuncer, Metin; Özalp, Cemal; Keskin, Azra
Background: Maintaining privacy in intensive care units (ICUs) is challenging because of high workload, invasive procedures, continuous monitoring and shared care environments. Patients with impaired consciousness may be particularly vulnerable because their ability to express privacy preferences, assert personal boundaries and advocate for themselves is limited. Aim: To explore intensive care nurses' experiences of protecting privacy when caring for patients with impaired consciousness. Study Design: A descriptive qualitative study was conducted with 20 intensive care nurses in Türkiye between March and April 2026. Data were collected through semi-structured online interviews and analysed using inductive thematic analysis. The study was reported in accordance with the Consolidated Criteria for Reporting Qualitative Research guidelines. Findings: Four themes were identified: the marginalisation of privacy under clinical priorities; structural and process-related constraints on privacy in intensive care; loss of subjectivity and the mechanisation of care in patients with impaired consciousness; and ethical and psychosocial implications of privacy violations. Conclusions: Privacy in intensive care is shaped not only by individual ethical awareness but also by workload, environmental conditions, care routines and communication practices. Patients with impaired consciousness have the same rights to privacy and dignity as other patients; however, their reduced ability to express preferences, assert personal boundaries and advocate for themselves may make privacy violations less visible and increase their dependence on nurses for protection. Relevance to Clinical Practice: Protecting the privacy of patients with impaired consciousness in ICUs requires structured care routines, standardised bedside communication, minimisation of unnecessary exposure during procedures and targeted ethical awareness training to support dignity in everyday practice.
- MakaleYalnız künye2026Scopus SJRQ2Assessment of gamma-ray attenuation properties in advanced ceramics incorporating colemanite, pyrophyllite, and plastic clay
Uysal, Turan; Kaya, Selim
This study investigates the gamma-ray and neutron shielding performance of advanced ceramic composites containing colemanite, pyrophyllite, and plastic clay as environmentally friendly alternatives to conventional lead-based shielding materials. Gamma-ray attenuation properties were evaluated over the energy range of 59.54–2000 keV using theoretical calculations from WinXCOM and Monte Carlo simulations performed with the EGS4 code. Excellent agreement between the two methods confirmed the reliability of the simulation results. The mass attenuation coefficient (μ/ρ) decreased with increasing photon energy due to the transition from photoelectric absorption to Compton scattering and pair production mechanisms. Correspondingly, the half-value layer (HVL) and mean free path (MFP) increased, while radiation protection efficiency (RPE) decreased with photon energy. The effective atomic number (Zeff) exhibited an energy-dependent decline, reflecting changes in dominant photon–matter interaction processes. Neutron shielding performance improved with increasing colemanite content owing to the presence of boron-rich phases, and Sample-5 exhibited the highest fast neutron removal cross-section (ΣR = 0.11062 cm−1). The same sample also showed the highest gamma-ray kerma coefficients, indicating enhanced energy absorption capability. Overall, the results demonstrate that colemanite-enriched ceramic composites provide effective combined gamma-ray and neutron shielding and represent promising, sustainable, and non-toxic alternatives for radiation protection applications.
- MakaleAçık Erişim2026Scopus SJRQ1Match success in football: insights from raw and possession-normalized key performance indicators in the Turkish professional league
Sever, Ozan; Öncü, Çağdaş; Öztaşyonar, Yunus; Aksoy, Ömer; Bayrakdaroğlu, Serdar
Background: Match-performance indicators are widely used to explain success in football; however, traditional analyses based solely on absolute key performance indicators (KPIs) may overlook contextual factors such as ball possession and phase of play. This study aimed to examine match-performance indicators associated with winning in Turkish professional football using two complementary approaches: a raw KPI model based on absolute match actions and a possession- and phase-of-play–normalized KPI model accounting for contextual opportunity. Methodology: Match data were obtained from a validated event-based database covering six consecutive seasons, yielding 2,728 team observations from 1,364 win–loss matches. Descriptive comparisons between winning and losing teams were conducted, followed by multivariate binary logistic regression analyses to identify performance indicators independently associated with match success under both modeling approaches. Results: At the descriptive level, winning teams demonstrated higher values for shots, shots on target, accurate passes, opponent-half accurate passes, accurate crosses (%), and opponent-half accurate passes (%), whereas total possession and total passes did not differ significantly between groups. In terms of disciplinary indicators, losing teams received significantly more yellow and red cards, whereas fouls committed were significantly higher in winning teams (p = 0.014). However, the normalized indicator (fouls committed per out-of-possession) did not differ significantly between groups. In the raw KPI model, positive predictors of match success included shots on target (OR = 1.58), accurate crosses (OR = 1.10), opponent-half accurate passes (OR = 1.01), and fouls committed (OR = 1.04). Negative predictors were total crosses (OR = 0.92), yellow cards (OR = 0.89), and red cards (OR = 0.49). In the possession-normalized model, significant positive predictors were shots on target per possession, accurate crosses per possession, and fouls committed per out-of-possession. Significant negative predictors included crosses per possession, accurate crosses (%), yellow cards per out-of-possession, and red cards per out-of-possession. Conclusions: The findings indicate that combining absolute performance indicators with context-sensitive normalized metrics may provide a more comprehensive perspective on match success in football. Offensive efficiency and disciplinary control emerged as key correlates of winning, particularly when evaluated relative to possession and phase-of-play contexts. These findings suggest the potential value of integrating contextualized performance analysis into match evaluation and performance analysis frameworks.
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ2Computational prioritization of multi-target inhibitors: explainable QSAR and docking-based discovery of dual AChE/BACE1 chemotypes
Bozkır, İsa; İbişoğlu, Merve Seda; Kayıkçıoğlu Bozkır, İlknur; Güler, Halil İbrahim
The discovery of dual acetylcholinesterase (AChE) and β-secretase (BACE1) inhibitors remains a promising strategy against multifactorial Alzheimer’s disease. Here, rigorously curated ChEMBL-derived data were used to develop explainable QSAR (Quantitative structure–activity relationship) models for dual-inhibition prioritization. Molecules were standardized, near-duplicates were removed using a Tanimoto similarity threshold (≥ 0.80), and physicochemical outliers were filtered prior to modeling. Multiple classifiers (including Light Gradient-Boosting Machine, eXtreme Gradient Boosting, Random Forest, Support Vector Machine, k-Nearest Neighbors and Gradient Boosting Decision Trees) and fingerprints (e.g., RDKit fingerprints, Extended Connectivity Fingerprint) were benchmarked under scaffold-based nested cross-validation to prevent data leakage. Class imbalance was handled with SMOTETomek applied strictly within training folds. Model selection relied on F-Score, Area Under the Precision–Recall Curve, Matthews Correlation Coefficient (MCC), and Recall, and performance was accompanied by bootstrap confidence intervals, calibration curves, and Y-randomization controls. In classification, the top model (GBDT + ECFP6) achieved strong generalization (Recall ≈ 1.00, PR-AUC ≈ 0.84, MCC ≈ 0.81, F1 Score ≈ 0.84). Shapley Additive Explanations (SHAP) analysis highlighted aromatic and hydrogen-bonding substructures as key positive contributors. Prospective candidates (e.g., CHEMBL5082250, CHEMBL1651126, CHEMBL1651127) were evaluated by active-site-focused docking against AChE (PDB: 4EY7) and BACE1 (PDB: 2G94) with essential waters retained; docking scores (ΔG, kcal·mol⁻1) were used for relative ranking of the ligands. SwissADME/pkCSM profiling suggested CNS-relevant properties (e.g., MPO, logBB, P-gp liability) and acceptable oral drug-likeness. Collectively, the workflow provides a reproducible and transparent pipeline for prioritizing dual AChE/BACE1 chemotypes and nominates testable scaffolds for experimental validation.
AtıfScopus2WoS2OpenAlex5İncele - MakaleAçık Erişim2026Scopus SJRQ1Process Intensification Sonocatalytic Degradation of Malachite Green Wastewater over Hydrothermally Engineered M-ZLT@Co3O4 Nanocatalyst: Structure–Activity Relationships, Radical-Mediated Mechanism and Degradation Pathways
Kıranşan, Murat
This study reports the sonocatalytic degradation of malachite green (MG) in media using synthesized Co3O4 nanoparticles and a CTAB-modified zeolite supported Co3O4 hybrid nanocatalyst (M-ZLT@Co3O4). The catalysts were characterized by XRD, FT-IR, SEM-EDX, TEM, XRF, N2 adsorption–desorption, BET, and BJH analyses, verifying crystalline Co3O4 formation, successful immobilization on the modified zeolite support, porous architecture, morphology and elemental distribution. Under optimized conditions of 1 g L−1 catalyst dosage, 20 mg L−1 MG concentration, natural pH, and 300 W L−1 ultrasonic power, M-ZLT@Co3O4 achieved 99.31% ± 0.45% degradation within 120 min. Decreasing the MG concentration to 5 mg L−1 increased the efficiency to 99.96% ± 0.64%, confirming high activity at low pollutant loading. The degradation followed pseudo-first-order kinetics, with kapp values of 0.0042–0.0595 min−1 depending on catalyst dosage, 0.0046–0.0667 min−1 for initial MG concentration, and 0.0117–0.0620 min−1 under pH conditions. Water matrix inhibition followed distilled water (99.31%) > tap water (96.08%) > river water (88.84%) > lake water (86.90%), whereas higher ultrasonic power increased degradation from 91.98% at 200 W L−1 to 99.90% at 500 W L−1. Dye degradation followed MG (99.31%) > CR (95.78%) > BY2 (92.15%) > MV (90.24%) > AO7 (85.62%) > RB19 (82.49%). Comparative tests demonstrated performance for US/M-ZLT@Co3O4 (99.31%) compared with US/Co3O4 nanoparticles (78.48%), US/ZLT (72.86%), and US/MG alone (35.71%). The best activity was obtained at 0.8–2 g L−1 catalyst dosage and 5–20 mg L−1 MG concentration, while reusability tests showed a decrease from 99.31% to 78.82% after six cycles, indicating promising stability.
- MakaleAçık Erişim2026Scopus SJRQ1Turkish Adaptation, Psychometric Validity and Measurement Invariance of the Reasons for Implicit Rationing of the Nursing Care Scale
Özalp, Cemal; Gerçek, Abdullah; Tuncer, Metin
Aim: This study aimed to adapt the Reasons for Implicit Rationing of Nursing Care Scale into Turkish and evaluate its validity, reliability and measurement invariance among nurses in Türkiye. Background: Implicit rationing of nursing care may compromise care quality and patient safety and is influenced by organizational, resource-related and communication factors. A culturally valid instrument is needed to identify the factors contributing to implicit rationing of nursing care within the Turkish healthcare context. Design: A methodological, cross-sectional psychometric validation study. Method: Data were collected between July and December 2025 from nurses working in a public hospital in Türkiye. The source population comprised 900 nurses and 411 nurses were included in the final sample using convenience sampling. Data were collected using the Personal Information Form and the Reasons for Implicit Rationing of Nursing Care Scale. Construct validity was examined using exploratory and confirmatory factor analyses on randomly divided samples. Convergent and discriminant validity and gender-based measurement invariance were assessed. Reliability was evaluated using Cronbach's alpha, McDonald's omega and the intraclass correlation coefficient. Results: The Kaiser–Meyer–Olkin value was 0.936, indicating that the data were suitable for factor analysis. Exploratory factor analysis revealed a two-factor structure consistent with the original scale, explaining 74.30% of the total variance. Confirmatory factor analysis demonstrated acceptable model fit. Convergent validity was supported, whereas the heterotrait–monotrait ratio value indicated borderline discriminant validity. Measurement invariance across genders was largely supported at the configural, metric and scalar levels. The scale demonstrated high internal consistency and temporal stability, with a Cronbach's alpha value of 0.941, a McDonald's omega value of 0.932 and an intraclass correlation coefficient value of 0.873. Conclusion: The Turkish version of the Reasons for Implicit Rationing of Nursing Care Scale is a valid, reliable and gender-invariant instrument. It can be confidently used in Turkish clinical settings to assess factors contributing to implicit rationing of nursing care.
- MakaleAçık Erişim2026Scopus SJRQ1Psychosocial dimension of adolescent pregnancy: a phenomenological study on life experiences
Ediz, Çiçek; Uzun, Sevda
Aim: This study aimed to assess the lived experiences of adolescent pregnant young women, with a specific focus on the psychosocial aspect of adolescent pregnancy, using a phenomenological approach. Design: Employing the phenomenological research method, semi-structured in-depth interviews were conducted between 3 August and 18 August 2023 with 15 young women (mean age = 21.86 years; SD = 1.06) living in a province in eastern Turkey who had undergone adolescent pregnancy 3–5 years before. Methods: The criterion sampling method, a form of purposive sampling, was used to form the sample group. Interviews were carried out until data saturation was reached. All interviews were recorded and transcribed, and thematic analysis was utilised to analyse the data. The study adhered to the COREQ checklist for reporting. Results: Through data analysis, three main categories (reflections on adolescent pregnancy, challenges due to adolescent pregnancy, and effects of adolescent pregnancy) and nine sub-themes (emotions, roles and responsibilities, perception of social support, cognitive, emotional, behavioural, mental, physical, and social) emerged. Conclusion: Our study highlights the adverse psychosocial impact of adolescent pregnancy on young women. Young women who got married at an early age before attaining full physical, social, and psychological maturity grappled with the substantial burdens of adolescent pregnancy and adjusting to their new roles. The study’s implications are significant, emphasising the necessity of addressing the psychosocial facets of adolescent marriage and pregnancy, and gaining valuable insights for the future.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2026Scopus SJRQ1Weight self-stigma, weight bias internalization, and eating attitudes in relation to body appreciation
Koçak, Tevfik; Kocyigit, Emine; Demirel Ozbek, Yagmur; Celik, İsa
Objective: This study aimed to investigate the relationships between weight self-stigma, weight bias internalization, eating attitudes, and body appreciation in young adults, and to ascertain the distinct impact of these variables on body appreciation. Methods: A cross-sectional study was carried out including young adults aged 19 to 35 years, comprising 69.6% females and 30.4% males. Participants completed a questionnaire evaluating weight self-stigma, internalization of weight bias, eating attitudes, and body appreciation. Hierarchical multiple regression analyses were used to assess the additional impacts of weight-related stigma and eating attitudes on body appreciation, while adjusting for demographic and anthropometric factors. Results: Weight self-stigma, particularly the internalization of weight bias, showed a significant negative association with body appreciation. Weight self-stigma and its subdimensions (self-devaluation and fear of enacted stigma) had substantial negative correlations with body appreciation. These correlations encompassed the subdimensions of body appreciation, specifically general body appreciation and body image investment. While eating attitudes did not show a significant correlation with body appreciation at the bivariate level, they became a significant predictor in the hierarchical regression model, suggesting a conditional (suppression) effect after accounting for weight-related stigma and BMI. Conclusion: The findings emphasize the important function of weight-related stigma in diminishing body appreciation among young adults and stress the necessity of examining eating attitudes in conjunction with stigma-related factors. Interventions designed to enhance positive body image should focus on both internalized weight stigma and maladaptive eating-related attitudes.
AtıfScopus1WoS1OpenAlex1İncele - MakaleYalnız künye2026Scopus SJRQ2The effect of dance intervention on cognitive functions and quality of life in patients with Chronic Stroke: A single-blind, randomized controlled trial
Cin, Aynur; Demirağ, Hatice; Hintistan, Sevilay
Objective This study aimed to determine the effect of dance interventions on cognitive functions and quality of life in chronic stroke patients. Methods This research used a single-blind randomized controlled trial design involving 40 chronic stroke patients at X State Hospital who were divided into a dance intervention group and a control group. The dance group was given 60 min of sessions three times a week for 12 weeks under the guidance of a dance instructor. Both groups were pre-tested and post-tested using the Stroke Specific Quality of Life Scale (SS-QOL) and Montreal Cognitive Assessment (MoCA). Results The dance intervention group experienced significant improvements in SS-QOL sub-dimensions (energy activities, personality, social and family roles, thinking, language, mood) as well as MoCA scores compared to the control group which had deteriorated over time ( p < 0.001). Conclusion Dance interventions can significantly improve cognitive function and quality of life among chronic stroke patients. The study was registered on Clinical Trials (NCT06145503).
- MakaleAçık Erişim2026Scopus SJRQ1Valorization of pomegranate peel waste through pyrolysis-liquid-assisted ultrasound extraction: antioxidant, antibacterial and targeted phytochemical characterization
Gül, Abdulkadir; Aydoğmuş, Ercan; Özgen, İnanç; Yılmaz, Fırat; Deniz, Sermin; Arslanoğlu, Hasan
Background: Pomegranate (Punica granatum L.) peel is a phenolic-rich processing by-product, but its valorization commonly relies on conventional solvents. This study examined an integrated approach in which pomegranate peel pyrolysis liquid (PP-PL) was repurposed as the extraction medium for ultrasound-assisted extraction (UAE) of the same biomass. The methodological originality lies specifically in using biomass-derived PP-PL in UAE. Results: PP-PL-assisted extract (PP-E) and an aqueous control extract (AQ-E), prepared from the same peel batch under identical UAE conditions, were compared. The apparent gravimetric recovery of PP-E was 202.5 g kg−1. PP-E showed approximately two-fold higher total phenolic and flavonoid contents than AQ-E. In vitro agar well diffusion screening revealed the largest inhibition zone for PP-E against Staphylococcus aureus at 80 g L−1 (22.65 ± 1.50 mm), whereas AQ-E produced no detectable inhibition zones against the tested strains at the same concentration. PP-E achieved DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS+ (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) radical-scavenging values of 92.42 ± 0.25% and 97.00 ± 0.17%, respectively, and showed pronounced total antioxidant capacity and iron(III) ion (Fe3+)- and copper(II) ion (Cu2+)-reducing capacities. Targeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) using authentic standards quantified six phenolics, with ellagic acid as the predominant analyte (2015.10 mg kg−1 extract). Conclusion: Integration of pomegranate peel pyrolysis with PP-PL-assisted UAE generated an extract exhibiting in vitro antioxidant properties and antibacterial potential in agar well diffusion screening, providing an alternative route for pomegranate peel valorization. This strategy supports the further development of biomass-derived extraction media for recovering value-added compounds from agro-industrial residues.
- MakaleAçık Erişim2026Scopus SJRQ2Fully automated 3D volumetric analysis of masticatory muscles in a pediatric population: A CT-based normative morphometric study
Kanber Uzun, Özlem; Ertemoğlu Öksüz, Canan; Kalkışım, Şahi Nur; Palancı, Özgür; Yıldırım, Yusuf İslam
The masticatory muscles play a fundamental role in craniofacial growth and development, yet normative volumetric data encompassing all four muscles across the full pediatric age range remain poorly characterized. The aim of this study was to establish age- and sex-specific normative reference values for the volumetric development of masticatory muscles in a normal pediatric population (0–17 years) using a fully automated 3D segmentation method. This retrospective, cross-sectional study included 258 normal pediatric individuals stratified into four age groups based on biomechanical milestones (0–5, 6–9, 10–13, and 14–17 years). Bilateral volumes of the masticatory muscles were automatically calculated using TotalSegmentator in the 3D Slicer environment. Two-way analysis of variance and Bonferroni post-hoc tests were applied. All muscles showed significant volume increases with age (p < 0.001), with the masseter demonstrating the greatest increase (199%). No sex differences were observed in 0–5 years; significant male-favoring differentiation began from 6 to 9 years. The temporalis muscle exhibited a biphasic sex differentiation pattern, with no significant difference at 10–13 years despite significance at 6–9 and 14–17 years. The highest sex-related effect sizes were observed in the pterygoid muscles (medial pterygoid ηp² = 0.176; lateral pterygoid ηp² = 0.160). Bilateral asymmetry analyses revealed left-sided favoring in the masseter, a lateralization trend in the temporalis (exploratory), right-sided favoring in the medial pterygoid, and sex-specific lateralization in the lateral pterygoid. These findings provide a large-scale CT-based normative reference for pediatric masticatory muscles, demonstrating muscle-specific volumetric patterns and variable sex differentiation, with normative ranges supporting clinical decision-making in dentistry, craniofacial surgery, and pediatric radiology.
- MakaleAçık Erişim2026Scopus SJRQ1Comparative Mechanical and Thermal Performance of Graphene- and Silver Nanoparticle-Reinforced PLA Fabricated by FDM 3D Printing
Karabudak, Filiz
The increasing demand for high-performance and multifunctional polymer materials has driven interest in improving the mechanical properties of polymer components produced through additive manufacturing. This study aims to systematically investigate and comparatively evaluate the effects of low-content nanofiller incorporation on the structural, thermal, and mechanical performance of PLA-based materials produced via fused deposition modeling (FDM), with a focus on identifying filler-dependent behavior under different loading conditions. In this study, polylactic acid (PLA) composites reinforced with 0.5 wt.% graphene (Gr) and 0.5 wt.% silver (Ag) nanoparticles, added separately, were produced using fused deposition modeling (FDM) and comparatively investigated. Each nanofiller was incorporated individually into PLA-based filaments, and standard test specimens were fabricated via 3D printing. Structural, thermal, and mechanical properties were evaluated using tensile, compressive, and three-point bending tests, along with SEM, EDS, XRD, FTIR, DSC, and TGA analyses. The results showed that pure PLA exhibited typical brittle behavior and a single-stage thermal degradation profile. The tensile strength of pure PLA was 41.93 MPa, and the flexural strength was 70.76 MPa. The addition of 0.5 wt.% graphene led to noticeable improvements, particularly in flexural properties, while only a minimal (almost negligible) increase was observed in tensile strength, with tensile strength increasing to 42.24 MPa (+0.74%) and flexural strength increasing to 110.78 MPa (+56.6%). In contrast, 0.5 wt.% Ag exhibited mixed and load-dependent mechanical behavior, with slight improvements in flexural strength but reductions in tensile and compressive properties, where tensile strength decreased to 22.13 MPa (−47.2%) while flexural strength increased to 112.06 MPa (+58.3%). Structural and thermal analyses indicated that both nanofillers did not significantly alter the PLA matrix chemically, while contributing to controlled changes in material properties primarily through physical interactions. The novelty of this work lies in the comparative evaluation of graphene and silver nanoparticle reinforcement at a fixed low loading level within FDM-processed PLA, combined with a comprehensive and correlated analysis of mechanical, structural, and thermal behavior on the same specimen sets, enabling a clearer understanding of filler-dependent performance mechanisms in additively manufactured nanocomposites. Overall, it was concluded that low-rate nanofiller additions, when properly dispersed, may lead to selective improvements in the performance of PLA-based composites depending on filler type and loading mode, and show potential for advanced engineering applications such as lightweight structural components, functional sensors, and additive-manufactured parts requiring tailored mechanical performance and multifunctionality.
- MakaleAçık Erişim2026Scopus SJRQ1Cortical thickness and volume alterations in patients with high myopia: a magnetic resonance imaging study
Aydin, Emre; Palanci, Ozgur
Background: The retina and optic nerve are integral components of the visual system and maintain direct anatomical and functional connections with the brain. Both structures are markedly affected in high myopia (HM). Accordingly, characterizing brain structural alterations associated with HM may provide important insights into its underlying neurobiological mechanisms. Using brain magnetic resonance imaging (MRI), this study aimed to evaluate regional gray matter (GM) and white matter (WM) volume changes, their relative percentages, and cortical thickness alterations in individuals with HM. Methods: High-resolution structural MRI, together with visual acuity (VA), intraocular pressure (IOP), refractive error, axial length (AL), and anterior chamber depth (ACD), was used to compare 30 adults with HM and 22 healthy controls (HC). Regional brain volumes and cortical thickness were analyzed in the fusiform gyrus (FuG), inferior temporal gyrus (ITG), middle temporal gyrus (MTG), superior temporal gyrus (STG), and occipital subregions including the calcarine cortex (Calc), cuneus (Cun), lingual gyrus (LiG), inferior occipital gyrus (IOG), middle occipital gyrus (MOG), and superior occipital gyrus (SOG). Results: Compared with HCs, HM patients demonstrated significant volumetric increases in the ITG and MTG regions (all p < 0.05), with the left ITG remaining significant after false discovery rate (FDR) correction. No significant volumetric differences were observed in the fusiform or occipital regions. In contrast, cortical thickness analyses revealed significant thinning in the fusiform gyrus and bilateral occipital subregions, including the calcarine cortex, cuneus, lingual gyrus, and middle occipital gyrus (p = 0.000–0.026, FDR-corrected). Cortical thickness in the fusiform and occipital regions showed negative correlations with AL and ACD and positive correlations with spherical equivalent. Conclusions: High myopia is associated with region-specific brain structural alterations, characterized by volumetric increases in temporal regions and cortical thinning in fusiform and occipital areas, indicating that HM-related neuroanatomical changes extend beyond the ocular system to involve central nervous system structures. Trial registration: Not applicable.
AtıfScopus1WoS1İncele - MakaleYayıncıda açık erişim2026Scopus SJRQ1Effects of different conditioning activities performed after soccer-specific warm-up on post-activation performance enhancement
Kartal, Alper; Ilhan, Muhammet Taha; Ergin, Esin; Pancar, Zarife; Karaca, Burak; Yildiz, Yasin; Gulsen, Doğukan Batur Alp; Bayrakdaroğlu, Serdar
The post-activation performance enhancement (PAPE) effect has been widely studied; however, studies conducted under real-world conditions remain limited. Furthermore, investigations into how different conditioning activities (CAs) influence PAPE responses are also scarce. Therefore, this study investigates the acute effects of high-intensity barbell hip thrust (BHT) and back squat (BS) exercises, performed after a soccer-specific warm-up (Wup), on physical performance in soccer players. Seventeen male amateur soccer players participated in the study (mean age: 22.29 ± 3.60 years; height: 1.78 ± 0.06 m; body weight: 73.18 ± 8.44 kg). Participants attended 5 experimental sessions. In the first session, after anthropometric assessments, participants were familiarized with the exercises and tests. In the second session, one-repetition maximum (1RM) was tested for BS and HT exercises. In the following three sessions, two PAPE protocols and one traditional (TRAD) protocol were performed in a randomized order. In the TRAD protocol, players performed physical performance tests including countermovement jump (CMJ), 10-m and 30-m sprint, and zigzag agility 16 minutes after a soccer-specific Wup. In the PAPE protocols, players performed CAs (e.g., hip thrust or back squat) at 85% of 1RM for 2 sets of 3 repetitions following a soccer-specific Wup, and completed the tests 8 minutes later. Results from the linear mixed-effects models revealed no significant effect of protocol on any performance variable, including CMJ (F(2,32) = 1.554, p = 0.227), 10 m sprint (F(2,32) = 0.242, p = 0.786), 30 m sprint (F(2,32) = 0.453, p = 0.640), and change of direction (COD) performance (F(2,32) = 0.946, p = 0.399). Marginal R² values indicated that the protocol explained only a minimal proportion of variance in performance outcomes (0.005–0.030), whereas conditional R² and ICC values suggested that between-participant differences accounted for a substantial proportion of variance, particularly for CMJ and 30 m sprint performance. Bonferroni-adjusted pairwise comparisons further showed no significant differences between PAPEBHT, PAPEBS, and TRAD protocols for CMJ, 10 m sprint, 30 m sprint, or COD performance (all p > 0.05). In conclusion, neither PAPE protocol performed after a soccer-specific warm-up significantly enhanced or impaired subsequent CMJ, sprint, or COD performance compared with the traditional warm-up. These findings suggest that adding PAPEBHT or PAPEBS protocols after a soccer-specific warm-up may maintain subsequent performance without inducing measurable decrements; however, their ergogenic effectiveness may depend on individual factors such as players’ strength levels, recovery capacity, training status, and physical characteristics.
AtıfScopus1WoS1OpenAlex1İncele - Derleme MakaleYalnız künye2026Scopus SJRQ1Effectiveness of ShotBlocker for Pain in Adult Needle-Related Procedures: Systematic Review and Meta-Analysis
Korkmaz, Emine; Uzun, Sevda; Aydın, Esra
Objectives This study was conducted to evaluate the effect of ShotBlocker use on pain levels during needle-related procedures in adults. Design Systematic review and meta-analysis. Data sources Studies were searched in the PubMed, Web of Science, ScienceDirect, Google Scholar, and Higher Education Council (YÖK) Thesis Center databases without any year restrictions. Review/Analysis methods The search and study selection were conducted in accordance with the PRISMA 2020 guidelines, and 18 studies meeting the inclusion criteria were included in the analysis. Data extraction and methodological quality assessment were performed using the Joanna Briggs Institute (JBI) critical appraisal tools. Findings were evaluated using meta-analysis and narrative synthesis methods. Results In this systematic review and meta-analysis, ShotBlocker was found to be effective in reducing pain levels in adults (SMD = −1,011; 95% CI: −1.390 to −0.631; Z = −5,221; p < .001; I² = 91.4%). However, substantial heterogeneity was observed among the included studies (I² = 91.4%). Conclusions This study demonstrates that ShotBlocker may be an effective nonpharmacological method for reducing pain levels during needle-related procedures in adults. However, the results should be interpreted with caution because of the substantial heterogeneity among the included studies.
- MakaleAçık Erişim2026Scopus SJRQ3Investigation of the enzyme-inhibitory, antibacterial, and anticancer properties of metal phthalocyanines
Topal, Meryem; Topal, Fevzi; Yilmaz, Fırat; Bulut Atalay, Esra; Koçyiğit, Ümit Muhammet; Güzel, Emre
In this study, the enzyme inhibitory, antibacterial, and anticancer activities of a phthalonitrile derivative and its metal phthalocyanines (Pcs; indium, zinc, copper, cobalt, and manganese; 1–6) were investigated. The cobalt and manganese Pcs were synthesized for the first time in this study. The inhibitory activities of the symmetric Pcs, which were expected to interact with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) via their 4-(isopropylbenzyl)oxy substituents through host–guest interactions, were investigated. More selective inhibition of AChE than BChE was observed for these compounds. For AChE, CoPc was identified as the most potent inhibitor (IC50 = 14.81 nM), whereas for BChE, InPc was identified as the most potent inhibitor (IC50 = 56.35 nM). The Ki values indicated that most compounds exhibited competitive inhibition; copper phthalocyanine (CuPc) showed particularly strong inhibition against AChE (Ki = 3.08 nM ± 1.12), whereas the lowest Ki value against BChE was observed for MnPc (Ki = 25.98 ± 1.97 nM). Most compounds exhibited competitive inhibition; however, CuPc showed competitive inhibition toward AChE but a noncompetitive inhibition pattern toward BChE. Dual inhibition of AChE and BChE by these compounds may be promising for addressing cholinergic deficits associated with Alzheimer’s disease. In addition, the acceptability of compounds 1–6 with respect to pharmacological drug-likeness criteria was assessed based on predicted absorption, distribution, metabolism, excretion (ADME) outcomes. In antibacterial tests, varying levels of inhibition were observed against selected bacterial strains. In anticancer assays, all compounds exhibited high cytotoxicity against the MCF-7 breast cancer cell line. Higher antiproliferative activity was observed for CuPc than for the other compounds. Morphological changes were induced in cancer cells by CuPc and MnPc. Overall, these compounds may have potential as enzyme inhibitors and as antibacterial and anticancer agents.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2026Scopus SJRQ2Comparative study of magnetic and electric quadrupole moments in boron (5B) isotopes
Ali, Ahmed H.; Tfiha, Amir D.; Zakaly, Hesham M. H.; Jarallah, Naz T.; Issa, Shams A. M.; Abdulqader, Abdulqader S.; Çelik, Necati; Bhuyan, M.
The magnetic moments and electric quadrupole moments of the B-5 isotopes were calculated using different nuclear interactions and sets of effective charges. Instead of relying on core polarization, the effective charges were adopted through a microscopic theoretical approach. The one-body density matrix (OBDM) elements for these isotopes were calculated using the NuShellX@MSU code. The calculations were carried out within the shell model framework, using both the p- and psd-model spaces (MS). These model spaces were selected for nuclei with proton number Z = 5 and neutron number N > 3. The theoretical results for magnetic and quadrupole moments were compared with available experimental data. Theoretical magnetic moments of the B-8,B-10,B-11,B-12,B-13 isotopes showed good agreement with experiment when using the p-MS with the pwt interaction, and the psd-MS with the psdmwk interaction. Similarly, the theoretical electric quadrupole moments reasonably well with the experimental values when using the p-MS with the pkuo interaction, and the psd-MS with the psdmwk interaction.
- MakaleAçık Erişim2026Scopus SJRQ1Inspiratory muscle training enhances jumping power and shooting performance in elite air pistol athletes
Aydin, Ahmet Serhat; Yilmaz, Coskun; Söyler, Mehmet; Güney, Gamze; Eyüboglu, Ender; Karakulak, Izzet; Ceylan, Tulay; Altug, Tolga; Burac, Daniela Giconda; Sahinler, Yunus
Background Inspiratory muscle training (IMT) has been shown to enhance respiratory efficiency, postural stabilization, and neuromuscular coordination in athletic populations. However, its effects in precision sports such as air pistol shooting remain insufficiently explored. This study investigated the impact of a 4-week IMT program on respiratory muscle strength, explosive lower-limb performance, reaction time, and shooting accuracy in competitive air pistol athletes. Methods Twenty trained male air pistol athletes (age 18-35 years) were randomly assigned to an IMT group (n = 10) or a control group (n = 10). The IMT group performed supervised inspiratory muscle training twice daily (30 breaths/session), six days per week, for four weeks, using a threshold-loading device set initially at 40% of maximal inspiratory pressure (MIP), with progressive overload applied weekly. Both groups maintained their regular shooting training routines. Pre- and post-intervention assessments included countermovement jump (CMJ) and squat jump (SJ) performance (OptoJump), visual and auditory reaction time (Cognitech), and shooting performance evaluated via the SCATT system. A two-way repeated-measures ANOVA (group & times; time) was used for statistical analysis. Results Significant group & times; time interactions were observed for CMJ height (p < 0.001, eta & sup2;p = 0.618), CMJ power (p = 0.007, eta & sup2;p = 0.345), SJ height (p = 0.050, eta & sup2;p = 0.184), and SJ power (p = 0.050, eta & sup2;p = 0.181), indicating meaningful improvements in explosive performance in the IMT group. Shooting accuracy demonstrated a large and statistically significant interaction effect (p < 0.001, eta & sup2;p = 0.532), with substantial improvement observed only in the IMT group. Reaction time variables showed favourable but non-significant trends (p > 0.05). Conclusion A short-term IMT intervention significantly enhanced lower-limb explosive performance and shooting accuracy in competitive air pistol athletes without altering overall training load. These findings suggest that IMT may represent an effective, low-cost adjunct strategy to improve neuromuscular stability and fine-motor precision in precision-sport athletes.
- MakaleAçık Erişim2026Scopus SJRQ1A multi-evidence computational and experimental strategy for Silene nerimaniae: combining phytochemical characterization, bioactivity assessment, and ADEFRank-HCT-116-based metabolite prioritization
Erharman, Ahmet; Yagi, Sakina; Uba, Abdullahi Ibrahim; Nikolic, Filip; Gasic, Uros; Acar, Mikail; Dogan, Nurettin; Koyuncu, Ismail; Yapici, Ismail; Gulcin, Ilhami
This study presents the first comprehensive evaluation of the phytochemical composition, antioxidant properties, enzyme inhibitory effects, and cytotoxic potential of Silene nerimaniae G.E.Gen & ccedil;, Kandemir & & Idot;.Gen & ccedil; (family Caryophyllaceae). Ethyl acetate, acetone, 70% acetone, and aqueous extracts were obtained from the aerial parts of the plant through maceration. Among the tested extracts, the acetone extract contained the highest total phenolic (24.37 mg GAE per g) and flavonoid (24.64 mg RE per g) contents. LC-MS analysis identified 52 bioactive constituents, including sugars, organic acids, phenolic acids, flavonoids, and fatty acids. The aqueous extract demonstrated the strongest radical scavenging activity against DPPH (23.02 mg TE per g) and ABTS (55.76 mg TE per g), as well as the highest Fe3+ reducing power (37.53 mg TE per g). In combination with the acetone extract, it also exhibited notable Cu2+ reducing activity (47.78 mg TE per g). Regarding enzyme inhibition, the ethyl acetate, acetone, and hydroacetone extracts displayed the strongest inhibitory activities against acetylcholinesterase (1.87 mg GALA per g), butyrylcholinesterase (2.92 mg GALA per g), and tyrosinase (60.44 mg KAE per g), respectively. All three extracts also inhibited alpha-amylase activity within the range of 0.73-0.77 mmol ACAE per g (p >= 0.05). In addition, the hydroacetone extract showed considerable inhibition of human carbonic anhydrase isoenzymes I (IC50 = 38.78 mu g mL-1) and II (IC50 = 19.59 mu g mL-1). The ethyl acetate extract exhibited the strongest cytotoxic effect against the colorectal cancer cell line HCT-116, with an IC50 value of 0.639 mu g mL-1 and a selectivity index of 1.7. To contextualize this HCT-116-associated activity at the metabolite level, an ADEFRank-HCT116 (abundance-domain-evidence fusion ranking) workflow was applied by integrating EtOAc abundance, HCT-116-oriented QSAR evidence, applicability-domain confidence, and structure-assignment reliability. This analysis prioritized diosmetin, luteolin, eriodyctiol, acacetin, and isorhamnetin as core candidates for structure-based follow-up. Molecular docking screening predicted favorable docking profiles for the prioritized candidates, while 100 ns molecular dynamics simulations were used to assess the dynamic stability of the representative luteolin-PI3K alpha, diosmetin-AKT1, and isorhamnetin-GSK-3 beta complexes. Taken together, these results indicate that S. nerimaniae may represent a valuable source of active compounds for various functional nutraceutical, cosmetic and pharmaceutical uses.