Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(46)
- Kulakaç, Nurşen(21)
- Aydin, Aydanur(16)
- Demir, Selim(16)
- Tuncer, Metin(16)
- Topal, Fevzi(15)
- Turan, Ibrahim(15)
- Yilmaz, Coskun(14)
- Bayrakdaroglu, Serdar(12)
- Koçak, Tevfik(11)
- Aliyazicioglu, Yuksel(10)
- Gulcin, Ilhami(10)
- Ozturk, Samet(10)
- Topal, Meryem(10)
- Ceylan, Halil Ibrahim(9)
- Ceylan, Levent(9)
- Kilinc, Kagan(9)
- Mentese, Ahmet(9)
- Ozdes, Duygu(9)
- Tuncer, Gülsüm Zekiye(9)
- Duran, Celal(8)
- Emirza, Elif Güzide(8)
- Yaman, Serap Ozer(8)
- Yılmaz, Coşkun(8)
- Baltacı, Cemalettin(7)
- Demirağ, Hatice(7)
- Hintistan, Sevilay(7)
- Kaya, Feridun(7)
- Küçük, Murat(7)
- Ürkek, Bayram(7)
- Şengül, Mustafa(7)
- Bayrakdaroğlu, Serdar(6)
- Deger, Orhan(6)
- Genc, Berna(6)
- Gül, Abdulkadir(6)
- Gülçin, Ilhami(6)
- Günen, Mehmet Akif(6)
- Gürsoy, Ayla(6)
- Kurnaz, Muammer(6)
- Supuran, Claudiu T.(6)
Yayınlar
- MakaleAçık Erişim2021Scopus SJRQ2Relationship of Cachexia with Self-Care Agency and Quality of Life in Cancer Patients: The Case of Turkey
Demirag, Hatice; Kulakaç, Nurşen; Hintistan, Sevilay; Çilingir, Dilek
Objective: This study aims to determine the effects of cachexia, causing major problems in the world and Turkey, on self-care agency and quality of life in cancer patients. Methods: The population of this cross-sectional and relationship-seeking study consisted of cancer patients in Turkey from April 1 to April 20, 2021. Using the snowball sampling method, 174 patients were sampled. 'Patient Information Form,' 'The European Organization for Research and Treatment of Cancer C30 Cancer Quality of Life Scale,' and 'Exercise of Self-Care Agency Scale' were used as data collection tools. Results: In the study, 52 patients (29.9%) were found to have cachexia. Function, general well-being, symptom (except insomnia), and self-care agency, which are subdimensions of the quality-of-life scale, were found to be significantly lower in patients with cachexia than patients without cachexia (P < 0.001). It was determined that there was a significant negative correlation between the cachexia status of the patients and the five basic functions in the functional scale (physical, role, emotional, cognitive, and social function), general well-being, and self-care agency, and there was a significant positive correlation between the cachexia status of the patients and the symptom scale (P < 0.001). According to the results of multiple linear regression analysis, it was found that the factor that significantly affected the cachexia status of the patients was their self-care agency (P < 0.001). Conclusions: It was determined that cachexia caused significantly lower self-care agency and quality of life in cancer patients. Furthermore, quality of life was related to self-care agency.
AtıfScopus5WoS6OpenAlex6İncele - MakaleAçık Erişim2021Scopus SJRQ2Prevalence of overweight, obesity and abdominal obesity in Health Sciences Faculty students
Tokaç Er, Nida; Doğan, Gökcen; Meriç, Çağdaş Salih; Yılmaz, Hacı Ömer; Öztürk, Meryem Elif; Ayhan, Nurcan Yabancı
Objectives: This study was carried out in order to determine the prevalence of obesity among the students of the Faculty of Health Sciences and to evaluate the anthropometric measurements of the students. Materials and methods: The population of the study was in total 984 volunteering undergraduate students from Ankara University Faculty of Health Sciences, Child Development, Midwifery, Nursing, Health Management and Social Work departments. The sociodemographic characteristics of the students were obtained with the help of the questionnaire and the anthropometric measurements by the researchers. SPSS package program was used for descriptive statistics, chi-square test and multiple logistic regression analysis for assessment of data. Results: 16.5% of the students participating in the study were overweight and 4.5% were obese. Approximately half of the students who are overweight and obese reported staying in the dormitory. Average BMI value in males is 23.1 kg/m2 and 22.3 kg/m2 in females. 29.1% of females are at risk in terms of abdominal obesity and 30.6% of males in terms of waist/height ratio. Male gender and presence of an obese person in the family increases the risk of being overweight or obese. Conclusions: Risky health behaviors are observed among university students and in order to avoid such behaviors, it is necessary to provide training especially on subjects such as nutrition and physical activity. Adopting the right nutritional habits and healthy lifestyle is important in individuals who will be the future healthcare professionals, for both their and future generations' health.
AtıfScopus7WoS5OpenAlex11İncele - MakaleYalnız künye2021Scopus SJRQ2The effect of homocysteine on the expression of CD36, PPARγ, and C/EBPα in adipose tissue of normal and obese mice
Mentese, Ahmet; Dogramaci, Seniz; Demir, Selim; Yaman, Serap Ozer; Ince, Imran; Altay, Diler Us; Erdem, Mehmet; Turan, Ibrahim; Alver, Ahmet
The purpose of this study was to investigate the effect of homocysteine (Hcy) on CD36, PPARγ, and C/EBPα gene and protein expression in adipose tissue obtained from normal and high-calorie diet obesity models. CD36, PPARγ, and C/EBPα gene expression and protein levels in adipose tissue specimens were determined using the RT-PCR and ELISA methods, respectively. Significantly increased CD36 gene expression was observed in adipose tissue from obese mice, while Hcy significantly reduced CD36 gene expression in adipose tissue from normal and obese mice. PPARγ and C/EBPα gene expression levels decreased significantly in all groups compared to the normal group. In addition, levels of both PPARγ and C/EBPα gene expression were lower with Hcy supplementation compared to their own controls. In conclusion, Hcy’s reduction of CD36 gene expression in adipose tissue may be one probable factor in hyperhomocysteinemia representing an independent risk factor for cardiovascular diseases.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2021Scopus SJRQ1Diagnosis of COVID-19 and non-COVID-19 patients by classifying only a single cough sound
Melek, Mesut
In the last month of 2019, a new virus emerged in China, spreading rapidly and affecting the whole world. This virus, which is called corona, is the most contagious type of virus that humanity has ever encountered. The virus has caused a huge crisis worldwide as it leads to severe infections and eventually death in humans. On March 11, 2020, it was announced by the World Health Organization that a COVID-19 outbreak has occurred. Computer-aided digital technologies, which eliminate many problems and provide convenience in people's lives, did not leave humanity alone in this regard and rushed to provide a solution for this unfortunate event. One of the important aspects in which computer-aided digital technologies can be effective is the diagnosis of the disease. Reverse transcription-polymerase chain reaction (RT-PCR), which is a standard and precise technique for diagnosing the disease, is an expensive and time-consuming method. Moreover, its availability is not the same all over the world. For this reason, it can be very attractive and important to distinguish the COVID-19 disease from a cold or flu through a cough sound analysis via smartphones which have entered into the lives of many people in recent years. In this study, we proposed a machine learning-based system to distinguish patients with COVID-19 from non-COVID-19 patients by analyzing only a single cough sound. Two different data sets were used, one accessible for the public and the other available on request. After combining the data sets, the features were obtained from the cough sounds using the mel-frequency cepstral coefficients (MFCCs) method, and then, they were classified with seven different machine learning classifiers. To determine the optimum values of hyperparameters for MFCCs and classifiers, the leave-one-out cross-validation (LOO-CV) strategy was implemented. Based on the results, the k-nearest neighbors classifier based on the Euclidean distance (kNN Euclidean) with the accuracy rate, sensitivity of COVID-19, sensitivity of non-COVID-19, F-measure, and area under the ROC curve (AUC) of 0.9833, 1.0000, 0.9720, 0.9799, and 0.9860, respectively, is more successful than other classifiers. Finally, the best and most effective features were determined for each classifier using the sequential forward selection (SFS) method. According to the results, the proposed system is excellent compared with similar studies in the literature and can be easily used in smartphones and facilitate the diagnosis of COVID-19 patients. In addition, since the used data set includes reflex and unconscious coughs, the results showed that conscious or unconscious coughing has no effect on the diagnosis of COVID-19 patients based on the cough sound.
AtıfScopus38WoS26OpenAlex45İncele - MakaleAçık Erişim2021Scopus SJRQ1A Two-Phase Approach using Mask R-CNN and 3D U-Net for High-Accuracy Automatic Segmentation of Pancreas in CT Imaging
Dogan, Ramazan Ozgur; Dogan, Hulya; Bayrak, Coskun; Kayikcioglu, Temel
Background and objective: The size, shape, and position of the pancreas are affected by the patient characteristics such as age, sex, adiposity. Owing to more complex anatomical structures (size, shape, and position) of the pancreas, specialists have some difficulties in the analysis of pancreatic diseases (diabetes, pancreatic cancer, pancreatitis). Therefore, the treatment of the disease requires enormous time and depends on the experience of specialists. In order to decrease the rate of pancreatic disease deaths and to assist the specialist in the analysis of pancreatic diseases, automatic pancreas segmentation techniques have been actively developed in the research article for many years. Methods: Although the rapid growth of deep learning and proving satisfactory performance in many medical image processing and computer vision applications, the maximum Dice Similarity Coefficients (DSC) value of these techniques related to automatic pancreas segmentation is only around 85% due to complex structure of the pancreas and other factors. Contrary to previous techniques which are required significantly higher computational power and memory, this paper suggests a novel two-phase approach for high-accuracy automatic pancreas segmentation in computed tomography (CT) imaging. The proposed approach consists of two phases; (1) Pancreas Localization, where the rough pancreas position is detected on the 2D CT slice by adopting Mask R-CNN model, (2) Pancreas Segmentation, where the segmented pancreas region is produced by refining the candidate pancreas region with 3D U-Net on the 2D sub-CT slices generated in the first phase. Both qualitative and quantitative assessments of the proposed approach are performed on the NIH data set. Results: In order to evaluate the achievement of the recommended approach, a total of 16 different automatic pancreas segmentation techniques reported in the literature are compared by utilizing performance assessment procedures which are Dice Similarity Coefficient (DSC), Jaccard Index (JI), Precision (PRE), Recall (REC), Pixel Accuracy (ACC), Specificity (SPE), Receiver Operating Characteristics (ROC) and Area under ROC curve (AUC). The average values of DSC, JI, REC and ACC are computed as 86.15%, 75.93%, 86.27%, 86.27% and 99.95% respectively, which are the best values among well-established studies for automatic pancreas segmentation. Conclusion: It is demonstrated with qualitative and quantitative results that our suggested two-phase approach creates more favorable results than other existing approaches.
AtıfScopus70WoS55OpenAlex68İncele - MakaleYalnız künye2021Scopus SJRQ1The Effect of Progressive Muscle Relaxation Exercises on Pain on Patients with Sickle Cell Disease: Randomized Controlled Study
Kazak, Aysun; Ozkaraman, Ayse
Purpose: The study aimed to evaluate the effect of progressive muscle relaxation exercises on pain in patients with sickle cell disease. Materials-Method: This randomized controlled interventional study was conducted in a hospital in Mersin, Turkey between October 2017 and July 2018. The study sample comprised 58 patients who were aged >18 years, conscious, had sickle cell disease, reported pain, and were treated with non-opioid or weak opioid analgesic based on the physician's recommendation (treatment group = 29, control group = 29). Data were collected by the individual presentation form and visual analog scale. During the study, both groups were treated with analgesics prescribed by the physician for three days. In addition to the analgesics, the treatment group was performed progressive muscle relaxation exercises for 30 minutes whereas the control group was rested. Pain level of both groups was evaluated at three time points every day for three days. In the study, frequency distributions and descriptive statistics were presented for categorical and numerical variables, respectively. Chi-square analysis, independent samples t-test, Mann–Whitney U test, three-way ANOVA, and Sidak test were used to analyze the difference between the variables. Results: The mean age of the patients was 29.59 ± 6.94 years, and 53.4% of the patients were female and 69% were single. The mean pain score of the treatment group at the third time point on days 1, 2, and 3 was significantly lower than the control group (p <.05). There was no statistically significant difference between the two groups in terms of coping methods for pain, pain location, and complaints accompanying pain (p >.05). Conclusion: Progressive muscle relaxation exercises were found to be effective in the pain management of patients with sickle cell anemia.
AtıfScopus7WoS5OpenAlex16İncele - MakaleYalnız künye2021Scopus SJRQ2From Turkey: First Report of KPC-3-and CTX-M-27-Producing Multidrug-Resistant Klebsiella pneumoniae ST147 Clone Carrying OmpK36 and Ompk37 Porin Mutations
Özad Düzgün, Azer
Aim: The aim of this study was to identify antimicrobial resistance genes, virulence factor genes, and porin loss or mutations exhibited by the multidrug-resistant Klebsiella pneumoniae strain. Materials and Methods: Whole-genome sequencing was done via the Illumina NovaSeq 6000 platform. Strain identification and antibiotic susceptibility testing of strains were performed by the Vitek 2 automated system. Multilocus sequence typing analysis was carried out using seven conserved housekeeping genes. Results: The strain was resistant to penicillins, cephalosporins, carbapenems, aminoglycosides, fluoroquinolones, fosfomycin, and trimethoprim/sulfamethoxazole. The isolate was found to carry KPC-3, CTX-M-27, SHV-11, SHV-67, and TEM-1 β-lactamases. The clonal subtype of the isolate was ST147, and it possessed wzi64 and wzc38 alleles. Fifteen different point mutations (N49S, L59V, R146H, V178P, G189T, F198Y, V202L, F207Y, A217S, T222L, D223G, H235N, A280V, N304E, and S346N) were detected in the OmpK36 porin. A frame shift was observed in OmpK35 and two different point mutations (I70M and I128M) were found in the OmpK37 porin, in addition to seven mutations observed on the AcrR. Conclusions: This study demonstrated for the first time that the ST147 clone produced CTX-M-27 as well as KPC-3. In addition, new mutations were detected in the outer membrane proteins. These mutations together with the production of extended-spectrum β-lactamase and carbapenemase were found to contribute to the resistance of the ST147 clone to carbapenem and other antibiotics.
AtıfScopus11WoS11OpenAlex9İncele - MakaleYalnız künye2021Scopus SJRQ2Preparation of melon peel biochar/CoFe2O4 as a new adsorbent for the separation and preconcentration of Cu(II), Cd(II), and Pb(II) ions by solid-phase extraction in water and vegetable samples
Ozdes, Duygu; Duran, Celal
The present research describes the successful preparation of melon peel biochar modified with CoFe2O4 (MPBC/CoFe2O4) followed by its usage as a new sorbent to separate, preconcentrate, and determine the toxic heavy metal ions by magnetic solid-phase extraction. The metal ion desorption was performed by 0.1 M HCl solution with a volume of 5.0 mL. Flame atomic absorption spectrometry (FAAS) was utilized for detection of the analyte levels. SEM–EDX, TEM, XRD, and FTIR techniques were carried out to illuminate the structure of MPBC/CoFe2O4. The fundamental variables affecting the adsorption and elution efficiencies of the analyte ions including solution pH, MPBC/CoFe2O4 amount, type and concentration of eluent, adsorption and desorption equilibrium time, and sample volume were optimized. The detection limits were calculated as 0.41, 1.82, and 3.16 µg L−1 for Cu2+, Cd2+, and Pb2+ ions, respectively, with the relative standard deviation of lower than 4.2%. There were no substantial interference effects on the analyte ion recovery due to the presence of foreign ions at high levels. Five minutes of contact time was adequate to attain the adsorption equilibrium. The adsorption capacity of MPBC/CoFe2O4 was obtained as 106.4, 65.4, and 188.7 mg g−1 for Cu2+, Cd2+, and Pb2+ ions, respectively, by utilizing Langmuir isotherm model. The pseudo-second order model is favorable to identify the adsorption kinetics. The method was validated by spike/recovery test, and then, it was successfully implemented to determine the aforementioned analyte levels in sea and stream water, pepper, black cabbage, eggplant, and tomato samples.
AtıfScopus40WoS38OpenAlex39İncele - MakaleYalnız künye2021Scopus SJRQ2Inhibition Profiles of Some Symmetric Sulfamides Derived from Phenethylamines on Human Carbonic Anhydrase I, and II Isoenzymes
Topal, Fevzi; Aksu, Kadir; Gulcin, Ilhami; Tümer, Ferhan; Goksu, Süleyman
In this work, the inhibitory effect of some symmetric sulfamides derived from phenethylamines were determined against human carbonic anhydrase (hCA) I, and II isoenzymes, and compared with standard compound acetazolamide. IC50 values were obtained from the Enzyme activity (%)-[Symmetric sulfamides] graphs. Also, Ki values were calculated from the Lineweaver-Burk graphs. Some symmetric sulfamides compounds (11–18) demonstrated excellent inhibition effects against hCA I, and II isoenzymes. These compounds demonstrated effective inhibitory profiles with IC50 values in ranging from 21.66–28.88 nM against hCA I, 14.44–30.13 nM against hCA II. Among these compounds, the best Ki value for hCA I (Ki: 8.34±1.60 nM) and hCA II (Ki: 16.40±1.00 nM) is compound number 11. Besides, the IC50 value of acetazolamide used as a standard was determined as hCA I, hCA II 57.75 nM, 49.50 nM, respectively. Moreover, in silico ADME-Tox study showed that all synthesized compounds (11–18) had good oral bioavailability in light of Jorgensen's rule of three, and of Lipinski's rule of five.
AtıfScopus13WoS12OpenAlex14İncele - MakaleYalnız künye2021Scopus SJRQ1The effects of noise levels on pain, anxiety, and sleep in patients
Aydın Sayılan, Aylin; Kulakaç, Nurşen; Sayılan, Samet
Background: Intensive care is a noisy environment for patients and one that affects pain, anxiety levels, and sleep quality. Aims and objectives: To determine the relationship between noise levels and pain, anxiety, and sleep levels in patients in intensive care units. Design: A descriptive and observational study design was used. Methods: This study was conducted between June and December 2018 in a public hospital and included 111 patients admitted to surgical critical care for at least 24 hours. Three Benetech Gm1351 manual sound level metres were used to measure noise. A Patient Information Form, a pain Visual Analog Scale (VAS), the Spielberger State-Trait Anxiety Inventory, and the Richards Campbell Sleep Questionnaire (RCSQ) were used for data collection. Results: The mean age of the patients was 57.29 years. The mean noise level detected in the intensive care unit was 66.52 dB (dB). Patients' mean pain VAS score was 3.79 ± 1.72, the mean State Anxiety Inventory score was 39.74 ± 2.98, and the mean total RCSQ score was 25.10 ± 13.17. Our findings show that patients in the intensive care unit are exposed to high noise levels and that, while this has no effect on pain, it significantly impacts anxiety and quality of sleep. Conclusions: Noise levels in intensive care units significantly exceed recommended thresholds, and this adversely affects patients' anxiety levels and sleep quality. It is important for suitably restful conditions to be provided for patients, to be aware of the potential for anxiety, and for these factors to be borne in mind when planning nursing interventions. Relevance to clinical practice: Further studies on the effects of noise levels on pain, anxiety, and sleep levels in patients admitted to intensive care units are needed.
AtıfScopus72WoS64OpenAlex83İncele - MakaleAçık Erişim2021Scopus SJRQ2The effect of COVID-19 anxiety levels of healthcare professionals on the quality of working life and related factors
Aydın, Aykut; Kulakaç, Nurşen; Aydın Sayılan, Aylin
Aim: This study aims to determine the effect of COVID-19 anxiety levels of healthcare professionals on their working life quality. Method: The sample of the descriptive, cross-sectional and correlational study consisted of healthcare professionals working in two university hospitals in western Turkey between May and July 2021. We used the “Personal Information Form, Coronavirus Anxiety Scale, and Working Life Quality Scale” as data collection tools. We used numbers and percentage calculations, arithmetic mean, median (25th–75th percentile), Mann–Whitney U test, Spearmen correlation analysis and Linear Regression analysis to analyse the data. Results: The mean score on the Quality of Life Scale of healthcare professionals was 3.74 ± 0.28, and the mean score on the Coronavirus Anxiety Scale (CAS) was 9.66 ± 6.06 (min. 0; max. 20). We found a negative and weakly significant relationship between the mean score of the CAS of healthcare professionals and the mean score of the employee quality of life scale. According to the results of the multiple linear regression analysis, we found the factors significantly affecting the anxiety states of healthcare professionals related to the Coronavirus are the quality of working life, age, sex and the state of caring for a patient with COVID-19. Conclusion: As a conclusion of this study, it was determined that healthcare professionals experienced anxiety, and anxiety decreased as ages, working years and the number of children they have increased. In addition, it was determined that as the anxiety of healthcare professionals increased, the quality of working life decreased.
AtıfScopus9WoS6İncele - MakaleAçık Erişim2021Scopus SJRQ1Land subsidence and its relations with sinkhole activity in karapınar region, turkey: A multi-sensor insar time series study
Orhan, Osman; Oliver-Cabrera, Talib; Wdowinski, Shimon; Yalvac, Sefa; Yakar, Murat
The Karapinar basin, located in the Central Anatolian part of Turkey, is subjected to land subsidence and sinkhole activity due to extensive groundwater withdrawal that began in the early 2000s. In this study, we use Interferometric Synthetic Aperture Radar (InSAR), Global Navigation Satellite System (GNSS), and groundwater level data to monitor and better understand the relations between groundwater extraction, land subsidence, and sinkhole formation in the Karapinar basin. The main observations used in the study are InSAR-derived subsidence velocity maps calculated from both Sentinel-1 (2014–2018) and COSMO-SkyMed (2016–2017) SAR data. Our analysis reveals broad areas of subsidence with rates exceeding 70 mm/yr. The InSAR-derived subsidence was compared with GNSS data acquired by a continuously operating GNSS station located in the study area, which show a similar rate of subsidence. The temporal characteristic of both InSAR and GNSS time series indicate a long-term subsidence signal superimposed by seasonal variability, which follows the overall groundwater level changes, with over 80% cross-correlation consistency. Our results also indicate that sinkhole activity is limited to slow subsidence areas, reflecting strong cohesion of near-surface rock layers that resist subsidence but yield to collapse in response to aquifer system deformation induced by groundwater extraction.
AtıfScopus63WoS55OpenAlex70İncele - MakaleYalnız künye2021Scopus SJRQ1Determination of START triage skill and knowledge levels of Prehospital Emergency Medical Staff: A cross sectional study
Aslan, Ramazan; Şahinöz, Saime; Şahinöz, Turgut
Background: Emergency medical staff working in pre-hospital (PH-staff) may encounter mass casualty incident (MCI) events. In these events these medical personnel should perform triage. The objective of this study is to determine the skill and knowledge levels of PH-staff about Simple Triage and Rapid Treatment (START) triage. Methods: With this cross-sectional, observational study we analyzed data from 127 PH-staff. Data was collected with the survey tool (response rate = 74.7%). Kruskal-Wallis H Test, Mann-Whitney U Test, and Spearman's Correlation analyzes were used in the data analysis by means of SPSS Software. Results: Of the participants, 63% were men, the median age was 24 years, 88 PH-staff (69.3%) intervened in MCI events, and 37 PH-staff (29.1%) applied START triage. The skill score was 60% and the knowledge score was 72.5%. There was a weak positive correlation between knowledge and skill scores (r = 0.337, p < 0.01). The knowledge level of the emergency medical technicians (EMTs) and paramedics was higher than those from the other professions. Conclusions: The triage knowledge and skill levels of the PH-staff were not low contrary to the expectations. The triage knowledge and skill levels of professions that did not have pre-hospital training such as paramedics and EMTs were low.
AtıfScopus7WoS6OpenAlex15İncele - MakaleYalnız künye2021Scopus SJRQ2Exopolysaccharide of Anoxybacillus pushchinoensis G11 has antitumor and antibiofilm activities
Genc, Berna; Taskin, Mesut; Adiguzel, Ahmet
Exopolysaccharides (EPS/EPSs) possess several various applications in the food and pharmaceutical industries. This study was performed to investigate the biological (antibiofilm and antitumor), rheological (temperature, shear rate, and density) and chemical (solubility, carbohydrate and protein content, composition, molecular weight, functional group analysis, thermal analysis, X-ray diffraction pattern and scanning electron microscopy) properties of the EPS, which was purified from the locally isolated thermophilic bacterium Anoxybacillus pushchinoensis G11 (MN720646). EPS was found to have antibiofilm and antitumor [lung (A-549) and colon (Caco-2 and HT-29) cancer] activities. The viscosity of EPS showing Newtonian flow was temperature dependent. As chemical properties, the EPS was found to be a heteropolysaccharide containing arabinose (57%), fructose (26%), glucose (12%), and galactose (5%). EPS contained 93% carbohydrates and 1.08% protein. The molecular weight of EPS was determined as 75.5 kDa. The FTIR analysis confirmed the presence of sulfate ester (band at 1217 cm−1), an indication of the antitumor effect. The EPS was semi-crystalline. It could maintain 36% of its weight at 800 °C and crystallization and melting temperatures were 221 and 255.6 °C. This is the first report on the EPS production potential and the biological activity of A. pushchinoensis.
AtıfScopus22WoS21OpenAlex25İncele - MakaleAçık Erişim2021Scopus SJRQ2In vitro glycemic index, antioxidant capacity and some physicochemical characteristics of deep-fried sorghum based gluten free chips
Kaplan, Mahmut; Yüksel, Ferhat; Karaman, Kevser
In this study, deep fried gluten free chips were manufactured using sorghum flour at different concentrations (5, 20, 35 and 50 g/100 g) and in vitro glycemic index, total antioxidant capacity and some physicochemical characteristics (dry matter, ash, oil, protein and color) and overall acceptability of the samples were investigated. Protein, oil and total dietary fiber levels of the samples ranged between 5.39–8.28, 23.58–29.10 and 5.59–6.60 g/100 g, respectively and increase in sorghum flour level resulted in an increase in these studied quality parameters of the chips samples. Ferric reducing antioxidant activity and DPPH radical scavenging performance were affected positively by the addition of sorghum flour. Total starch hydrolysis index and estimated glycemic index values were affected by the sorghum flour addition negatively due to the increased total dietary fiber content of the chips samples. All chips samples enriched with sorghum flour showed similar overall acceptability and increased sorghum concentration decreased the preference scores slightly. All these results could be considered for the manufacturing of the gluten free deep fried sorghum based chips samples.
AtıfScopus11WoS9OpenAlex11İncele - MakaleYayıncıda açık erişim2021Scopus SJRQ2An automatic EEG-based sleep staging system with introducing NAoSP and NAoGP as new metrics for sleep staging systems
Melek, Mesut; Manshouri, Negin; Kayikcioglu, Temel
Different biological signals are recorded in sleep labs during sleep for the diagnosis and treatment of human sleep problems. Classification of sleep stages with electroencephalography (EEG) is preferred to other biological signals due to its advantages such as providing clinical information, cost-effectiveness, comfort, and ease of use. The evaluation of EEG signals taken during sleep by clinicians is a tiring, time-consuming, and error-prone method. Therefore, it is clinically mandatory to determine sleep stages by using software-supported systems. Like all classification problems, the accuracy rate is used to compare the performance of studies in this domain, but this metric can be accurate when the number of observations is equal in classes. However, since there is not an equal number of observations in sleep stages, this metric is insufficient in the evaluation of such systems. For this purpose, in recent years, Cohen’s kappa coefficient and even the sensitivity of NREM1 have been used for comparing the performance of these systems. Still, none of them examine the system from all dimensions. Therefore, in this study, two new metrics based on the polygon area metric, called the normalized area of sensitivity polygon and normalized area of the general polygon, are proposed for the performance evaluation of sleep staging systems. In addition, a new sleep staging system is introduced using the applications offered by the MATLAB program. The existing systems discussed in the literature were examined with the proposed metrics, and the best systems were compared with the proposed sleep staging system. According to the results, the proposed system excels in comparison with the most advanced machine learning methods. The single-channel method introduced based on the proposed metrics can be used for robust and reliable sleep stage classification from all dimensions required for real-time applications.
AtıfScopus13WoS9OpenAlex16İncele - MakaleAçık Erişim2021Scopus SJRQ2An Investigation of the Effect of COVID-19 on OCD in Youth in the Context of Emotional Reactivity, Experiential Avoidance, Depression and Anxiety
Seçer, İsmail; Ulaş, Sümeyye
In addition to the serious physical and medical effects on individuals, the COVID-19 pandemic is likely to have short- and long-term psycho-social consequences, especially for young people. Nowadays, with psychological problems becoming more widely recognized in adolescents, it is possible that the fear and anxiety caused by the pandemic will trigger various anxiety disorders, OCD and similar negative outcomes. Considering that psychological qualities such as emotional reactivity and experiential avoidance observed in adolescents may increase the risk of such psycho-social disorders, in this study the relationship between fear of COVID-19 and OCD was investigated in a Turkish sample of 598 adolescents, and the mediating role of emotional reactivity, experiential avoidance and depression-anxiety in this relationship was examined. The data collection was performed online rather than in person because of the COVID-19 threat. A structural equation model was used to determine the direct and indirect predictive effects between variables in data analysis. The results of the study show that the effect of COVID-19 fear on OCD is mediated by emotional reactivity, experiential avoidance and depression-anxiety.
AtıfScopus97WoS98OpenAlex142İncele - Derleme MakaleAçık Erişim2021Scopus SJRQ1Microbulb and plantlet formation of a native bulbous flower, Lilium monodelphum M. Bieb, var. Armenum, through tissue culture propagation
AZERİ, F.N.; Öztürk, G.
The plant Lilium monadelphum M. Bieb. var. armenum (Mıscz. Ex Grossh) Davis et Henderson recognized as the caucasian lily grows in the Eastern Black Sea Region and is a perennial bulbous species belonging to the Liliaceae family. Its flowers, bulbs, and volatile oils are used in the perfume industry, as a folk medicine to treat eczema and abscess therapy, and as a tranquilizer among regional people respectively. Hence, it is commonly collected from the wild and could become endangered. In this study, we explored the optimal hormone treatment for efficient and rapid induction and production of this species in tissue culture. Explants taken from bulbs were cultured in Murashige and Skoog medium (MS medium, 1962) and modified with TDZ (thidiazuran) (0.5; 1.0; 2.0; 3.0; 5.0 mg/L), after which adventitious buds used for explants during the second stage were subcultured 4 different media supplemented with different concentrations of PAC (paclobutrazol) (0.1; 0.5; 1.0; 2.0 mg/L) to induce microbulbs formation. Microbulbs were cultured in a rooting medium containing IBA (0.5;1.0 mg/L). The highest bud regeneration was observed in medium containing 3.0 mg/L TDZ, 0.25 mg/L NAA and 0.1 mg/L GA3; the highest microbulb formation was observed in medium containing 2.0 mg/L PAC, 0.2 mg/L NAA, and 0.1 mg/L GA3. Besides, plant development from the microbulb was successful for roots in a medium containing 0.5 mg/I IBA and all of the plantlets obtained in tissue culture survived when transferred to the soil.
AtıfScopus16İncele - MakaleYalnız künye2021Scopus SJRQ2Effects of GSM 1800 band radiation on composition, structure and bioactivity of exopolysaccharides produced by yoghurt starter cultures
Karatas, Seyda Merve; Ekici, Lutfiye; Develi, Ibrahim; Dertli, Enes; Sagdic, Osman
In this study, the effects of GSM 1800 band radiation on composition, structure and bioactivity of exopolysaccharides (EPSs) produced by Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus were determined. For this, GSM 1800 band radiation was applied to both cultures and characteristics of EPSs extracted from the control groups (K) and the radiation stressed groups (R) were determined. An alteration in the chemical composition of the EPSs was observed and EPS production levels and molecular weights of the EPSs increased following the GSM 1800 band radiation application. Alterations in the functional groups, thermal and morphological characteristics of EPSs following the GSM 1800 band radiation application were confirmed by FTIR, TGA and SEM analysis, respectively. Importantly no alterations in the antioxidant and antibacterial activity of the EPSs were observed following the radiation application. These results suggested the effects of the GSM radiation on final characteristics of EPSs from yogurt starter cultures.
AtıfScopus8WoS5İncele - MakaleAçık Erişim2021Scopus SJRQ2Burnout levels and sleep quality of COVID-19 heroes
Aydin Sayilan, Aylin; Kulakaç, Nurşen; Uzun, Sevda
Purpose: This study was carried out to determine the burnout levels and sleep quality of nurses in the coronavirus disease-2019 process. Design and Methods: The population of this descriptive and cross-sectional study consisted of all nurses working in hospitals in Turkey. Findings: Nurses' mean scores were compared by gender. The emotional burnout and personal achievement scores of male nurses were higher than those of female nurses. Single nurses had significantly higher emotional exhaustion and depersonalization scores than married individuals. Nurses mostly experienced emotional exhaustion, and burnout levels increased in line with insomnia. Implications for Nursing Practice: Nurses struggling on the frontline during the pandemic were determined to be at risk of insomnia and burnout.
AtıfScopus66WoS62OpenAlex97İncele