Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(46)
- Kulakaç, Nurşen(21)
- Aydin, Aydanur(16)
- Demir, Selim(16)
- Tuncer, Metin(16)
- Topal, Fevzi(15)
- Turan, Ibrahim(15)
- Yilmaz, Coskun(14)
- Bayrakdaroglu, Serdar(12)
- Koçak, Tevfik(11)
- Aliyazicioglu, Yuksel(10)
- Gulcin, Ilhami(10)
- Ozturk, Samet(10)
- Topal, Meryem(10)
- Ceylan, Halil Ibrahim(9)
- Ceylan, Levent(9)
- Kilinc, Kagan(9)
- Mentese, Ahmet(9)
- Ozdes, Duygu(9)
- Tuncer, Gülsüm Zekiye(9)
- Duran, Celal(8)
- Emirza, Elif Güzide(8)
- Yaman, Serap Ozer(8)
- Yılmaz, Coşkun(8)
- Baltacı, Cemalettin(7)
- Demirağ, Hatice(7)
- Hintistan, Sevilay(7)
- Kaya, Feridun(7)
- Küçük, Murat(7)
- Ürkek, Bayram(7)
- Şengül, Mustafa(7)
- Bayrakdaroğlu, Serdar(6)
- Deger, Orhan(6)
- Genc, Berna(6)
- Gül, Abdulkadir(6)
- Gülçin, Ilhami(6)
- Günen, Mehmet Akif(6)
- Gürsoy, Ayla(6)
- Kurnaz, Muammer(6)
- Supuran, Claudiu T.(6)
Yayınlar
- MakaleAçık Erişim2020Scopus SJRQ2Educating children through their parents to prevent child sexual abuse in Turkey
Apaydın Cırık, Vildan; Efe, Emine; Velipaşaoğlu, Sevtap
Purpose: The aims of this study were to train parents to recognize and prevent child sexual abuse (CSA); evaluate the problems encountered by parents; and evaluate the overall effectiveness of the CSA training program. Design and Methods: The study used a pretest/posttest design. The study was conducted with a sample of 58 children (aged 3-6 years) and 64 parents. Findings: Children who received CSA prevention education from their parents demonstrated improved knowledge about private parts and about what they should do if they suspect sexual abuse. The parents stated that they encountered some problems (other family members objected to the child being given such training). Practise Implications: Children's risk of abuse may be reduced if their parents teach them about CSA correctly.
AtıfScopus26WoS23OpenAlex36İncele - MakaleAçık Erişim2020Scopus SJRQ1The Effect of the Fear of COVID-19 on Healthcare Professionals’ Psychological Adjustment Skills: Mediating Role of Experiential Avoidance and Psychological Resilience
Seçer, I; smail; Ulaş, Sümeyye; Karaman-Özlü, Zeynep
As the COVID-19 outbreak is rapidly spreading all over the world, it’s secondary consequences will negatively affect both societies and individuals. The target group, expected to be exposed to the secondary negative consequences most intensely during the pandemic process and afterward, is undoubtedly the healthcare professionals. In this research, the impact of the fear that healthcare professionals in Turkey developed against the outbreak of COVID-19 on their psychological adjustment skills is examined, and in this context, the mediating role of experiential avoidance and psychological resilience is examined. In this context, an answer was sought for the question “Does experiential avoidance and psychological resilience have a mediating role in the impact of COVID-19 fear on psychological adjustment skills of healthcare professionals?” The research was carried out with a total of 370 healthcare professionals reached via online data collection method. Structural equation modeling was used in the data analysis process, and as a result, it was determined that the fear of COVID-19 had a negative effect on the psychological adjustment in healthcare professionals; however, psychological resilience was found to have a protective function that limits this effect, and experiential avoidance has a risk factor that aggravates this effect. Findings obtained from the research are discussed in the context of the literature.
AtıfScopus54WoS47OpenAlex75İncele - MakaleAçık Erişim2020Scopus SJRQ1The Mediator Role of Academic Resilience in the Relationship of Anxiety Sensitivity, Social and Adaptive Functioning, and School Refusal With School Attachment in High School Students
Seçer, İsmail; Ulaş, Sümeyye
School has an important function in providing the environment for young people to acquire many skills and knowledge required by contemporary life, but the problems of attachment to school and problematic attendance all over the world reveal an increasing statistic. It is thought that some negative processes such as anxiety sensitivity, social and adaptive functioning, and school refusal can affect this problem. On the other hand, it is considered that the academic resilience of young people has an important protective function in terms of these risk factors. For this purpose, the mediator role of academic resilience between anxiety sensitivity, social and adaptive functioning, and school refusal and school attachment were examined in a Turkish sample of 452 high school students. In the process of data collection, the school refusal assessment scale, social and adaptive functioning scale, and academic resilience scale were adapted and used in the Turkish culture. In the data analysis, the structural equation model was used to determine the direct and indirect predictive effects between the variables. The results of the study showed that academic resilience fully mediated the relationship between anxiety sensitivity and school attachment, whereas it partially mediated the relationship between social and adaptive functioning and school refusal and school attachment. Based on the results of the study, it was evaluated that high academic resilience has a strong protective function against the problems of negative school attachment and problematic school absenteeism among young people, and this finding was discussed within the context of literature.
AtıfScopus45WoS22OpenAlex54İncele - MakaleYalnız künye2020Scopus SJRQ2Rosa canina Extract has Antiproliferative and Proapoptotic Effects on Human Lung and Prostate Cancer Cells
Kilinc, Kagan; Demir, Selim; Turan, Ibrahim; Mentese, Ahmet; Orem, Asim; Sonmez, Mehmet; Aliyazicioglu, Yuksel
Although several studies have investigated the cytotoxic effects of different Rosa species, there has been only limited research into the cytotoxic effect of Rosa canina. The purpose of this research was to evaluate the antioxidant properties, phenolic characterization, and cytotoxic effects of R. canina on human lung (A549) and prostate (PC-3) cancer cells and the possible mechanisms involved. The antioxidant properties and phenolic characterization of the extract were determined using spectrophotometric methods and RP-HPLC, respectively. The cytotoxic activity of the extract was determined using the MTT assay. The mechanism involved in the extract’s cytotoxic effect was then evaluated in terms of apoptosis, the cell cycle, mitochondrial membrane potential (MMP), and caspase activity using fluorometric and luminometric methods. The TPC value of the extract was 58.97 ± 2.22 mg gallic acid equivalents per gram sample, and ascorbic acid and p-coumaric acid were detected as major phenolics in the extract. R. canina extract exhibited a selective cytotoxic effect on A549 and PC-3 cells compared to normal fibroblast cells. The extract induced cell cycle arrest at the G1 phase and apoptosis via reduced MMP and increased caspase activity in these cells. Phytomedical applications of R. canina may represent promising approaches in the treatment of cancer.
AtıfScopus36WoS34OpenAlex40İncele - MakaleAçık Erişim2020Scopus SJRQ1An assessment of phenolic profiles, fatty acid compositions, and biological activities of two Helichrysum species: H. plicatum and H. chionophilum
Acet, Tuba; Ozcan, Kadriye; Zengin, Gokhan
In the present study, we aimed to search and compare the biological activities of the ethanol (EtOH), methanol (MeOH), and ethylacetate (EtOAc) solvent extracts of the flower, stem, and root parts of two Helichrysum plants (H. chionophilum (Hc) and H. plicatum subsp. plicatum (Hp)). The antioxidant properties were determined by using (2,2-diphenyl-1-picrylhydrazyl) (DPPH) and ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The enzyme inhibitory effects of the extracts were investigated on butyrylcholinesterase (BChE), acetylcholinesterase (AChE), α-glucosidase, and α-amylase. Palmitic acid (C 16:0) was also determined as major fatty acids in the tested oils (31.21%–67.68%). In both plants, it was found that the EtOAc extracts of the flowers had a strong antioxidant and enzyme inhibitory effect. In conclusion, the results obtained in the present study showed that H. chionophilum and H. plicatum can be seen as a promising source for the natural bioactive compounds that can be used in therapeutic applications. Practical applications: The members of the genus Helichrysum have been widely taken for therapeutic purposes in traditional medicine as well as food. In this context, we investigated the chemical characterization and biological activities of two Helichrysum species extracts (H. chionophilum and H. plicatum subsp. plicatum). Antioxidant capacity, enzyme inhibition and anti-microbial effects were tested for biological activities. Chemical characterization was identified by high performance liquid chromatography (HPLC) (for phenolic) and gas chromatography-flame ioanization detector (GC-FID) (for fatty acids). Based on our findings, the species may be valuable for designing novel food products.
AtıfScopus13WoS10OpenAlex24İncele - MakaleYalnız künye2020Scopus SJRQ1The Effect of Laughter Therapy on Anxiety: A Meta-Analysis
Demir Doǧan, Melike
This meta-Analysis was conducted to determine the effect of laughter therapy on anxiety. Randomized controlled clinical trials were reviewed on Google Scholar, PubMed, and ISI Web of Sciences databases. Four randomized controlled trials consisting of 157 participants were included in the meta-Analysis. Hedge's g test statistics were used to show the common effect between the laughter therapy and control groups in the meta-Analysis. Laughter therapy can decrease anxiety levels (standardized mean difference =-1.144; 95% CI,-1.950 to-0.338). Laughter therapy is an effective complementary method to decrease anxiety.
AtıfScopus38WoS30OpenAlex63İncele - MakaleYalnız künye2020Scopus SJRQ1Effects of kinesio tape application on pain, anxiety, and menstrual complaints in women with primary dysmenorrhea: A randomized sham-controlled trial
Toprak Celenay, Seyda; Kavalci, Basak; Karakus, Aysenur; Alkan, Afra
Aim: To investigate the effects of kinesio tape (KT) application on pain, anxiety, and menstrual complaints in women with PD and compare this application with control and sham tape (ST). Methods: Fifty-one women with PD were randomized into three groups: KT, ST, and control groups. No tape application was performed in the control group. KT was applied on the sacral and suprapubic regions with the ligament technique in the KT group, while it was applied on the trochanter major with no technique in the ST group. Pain, anxiety level, and menstrual complaints were assessed before and after the applications. Results: The decreases in pain, anxiety levels, and some menstrual complaints after the application were higher in the KT group than those in the other two groups (p < 0.05). Conclusion: KT application seems to be an effective method in decreasing pain, anxiety level, and some menstrual complaints in women with PD.
AtıfScopus23WoS18OpenAlex28İncele - MakaleYalnız künye2020Scopus SJRQ2Discovery and evaluation of inhibitory activity and mechanism of arylcoumarin derivatives on Theileria annulata enolase by in vitro and molecular docking studies
Yakarsonmez, Sinem; Danis, Ozkan; Mutlu, Ozal; Topuzogullari, Murat; Sariyer, Emrah; Yuce-Dursun, Basak; Turgut-Balik, Dilek
Abstract: In this study, the inhibition potential of 3- and 4-arylcoumarin derivatives on Theileria annulata enolase (TaENO) was assessed for the first time in the literature. Firstly, protein stabilization analyses of TaENO were performed and it was found that the enzyme remains stable with the addition of 6 M ethylene glycol at + 4 °C. Inhibitor screening analyses were carried out using 25 coumarin derivatives on highly purified TaENO (> 95%), and four coumarin derivatives [4-(3,4-dimethoxyphenyl)-6,7-dihydroxy-2H-chromen-2-one (C8); 4-(3,4-dihydroxyphenyl)-7,8 dihydroxy-2H-chromen-2-one (C9); 4-(3,4-dihydroxyphenyl)-6,7-dihydroxy-2H-chromen-2 one (C21); and 3-(3,4-dihydroxyphenyl)-7,8-dihydroxy-2H-chromen-2-one (C23)] showed the highest inhibitory effects with the IC50 values of 10.450, 13.170, 8.871 and 10.863 µM, respectively. The kinetic results indicated that these compounds inhibited the enzyme by uncompetitive inhibition. In addition, the successful binding of the most potent inhibitor (C21) into TaENO was confirmed by using MALDI-TOF mass spectrophotometry. Molecular docking analyses have predicted that C8 and C21 coumarin derivatives which showed high inhibitory effects on TaENO were interacted with high affinity to the potential regions out of the active site. Taken together, these coumarin derivatives (C8, C9, C21 and C23) are first known potent, nonsubstrate, uncompetitive inhibitors of TaENO and these results will facilitate further in vitro and in vivo analysis toward structure-based drug design studies. Graphic abstract: [Figure not available: see fulltext.]
AtıfScopus5WoS5OpenAlex6İncele - MakaleYalnız künye2020Scopus SJRQ2Synthesis of Microwave-Assisted Fluorescence Carbon Quantum Dots Using Roasted–Chickpeas and its Applications for Sensitive and Selective Detection of Fe3+ Ions
Başoğlu, Aysel; Ocak, Ümmühan; Gümrükçüoğlu, Abidin
A simple method for the green synthesis of fluorescent carbon quantum dots (CQDs) has been developed by using roasted chickpea as carbon source in one-step without using any chemical. Interestingly, not only the carbon source of CQDs and the whole synthesis procedure are environmentally friendly, but also the synthesized CQDs have shown many advantageous properties such as high fluorescence intensity, excellent photostability, and good water solubility. CQDs which were firstly synthesized from roasted–chickpeas by a microwave-assisted pyrolysis have been characterized using UV-vis absorption spectroscopy, fluorescence spectroscopy, fourier transform infrared spectroscopy (FTIR) spectroscopy, X-ray diffraction (XRD) technique and transmission electron microscopy (TEM). In addition, the details of the structure have been revealed by the electron diffraction (SAED; selected-area electron diffraction) method based on the TEM images. The synthesized CQDs emits blue fluorescence under UV light (at 365 nm). A microwave oven (350 watts) was used to prepare CQDs in 120 s. The effect of various metal ions on the fluorescence intensity of CQDs was investigated in order to determine its utality in the detection of metal ions. It was determined that 1.38 mg/L of Fe3+ ions quenched the fluorescence intensity of the CQDs by 65%. The linear range is observed between 11.25 and 37.50 μM with limit of detection (LOD) and limit of quantification (LOQ) of 2.74 μM and 8.22 μM, respectively. CQDs which are highly selective and sensitive for Fe3+ ions was used to determine Fe3+ ions in certified reference material (CRM-SA-C). Fe3+ ions concentration was determined with precision values of more than 95% as intra-day and inter-day relative standard deviation (RSD%) is 5 at room temperature.
AtıfScopus123WoS107OpenAlex127İncele - MakaleYalnız künye2020Scopus SJRQ1The effect of expressed breast milk, swaddling and facilitated tucking methods in reducing the pain caused by orogastric tube insertion in preterm infants: A randomized controlled trial
Apaydin Cirik, Vildan; Efe, Emine
Background: Orogastric tube feeding is used to support the nutrition of preterm infants. Although nonpharmacological methods are effective in reducing the pain caused by orogastric tube insertion, only limited studies have been found addressing this pain. No study has used combined nonpharmacological methods to reduce this orogastric tube insertion pain. Objective: This randomized controlled study aims to compare the effects of expressed breast milk, swaddling, facilitated tucking, expressed breast milk+swaddling, expressed breast milk+facilitated tucking and routine care methods on preterm infant pain and the physiological parameters (i.e., heart rate, oxygen saturation) before, during and after orogastric tube insertion procedures. Design: Randomised controlled trial. Setting: Three level III neonatal intensive care units in Turkey. Method: Preterm infants born at 32–34 weeks gestation were randomly assigned to six groups: routine care (n = 33), swaddling (n = 30), facilitated tucking (n = 32), expressed breast milk (n = 31), swaddling+expressed breast milk group (n = 30), and facilitated tucking+expressed breast milk group (n = 31). Orogastric tube insertion included four phases: baseline (the last one minute of 30 min without stimuli), the insertion, recovery (one minute after insertion), and recovery (two minutes after insertion). The four phases were videotaped. Premature infant pain profile score, heart rate and oxygen saturation were assessed by two independent evaluators who were blinded to the purpose of the study. Data were assessed by analysis of variance for the multiple repeated measurements, bonferroni and generalised estimating equation logistic regression. Results: There was a significant main effect of the intervention groups for all the pain and physiological parameters (heart rate: F = 3.99, p = 0.001; oxygen saturation: F = 5.22, p<0.001; pain profile 1 score: F = 9.55, p<0.001; pain profile 2 score: F = 9.74, p<0.001). The use of the nonpharmacological methods combined or alone was more effective in reducing infants’ pain profile score and physiological variables than routine care. Infants receiving swaddling+expressed breast milk had significantly lower pain profile scores during the insertion (phase2) (5.2 ± 1.7) than those receiving routine care (9.5 ± 3.6), swaddling (8.8 ± 2.9), facilitated tucking (7.2 ± 3.2), expressed breast milk (7.9 ± 2.6), facilitated tucking+expressed breast milk (6.6 ± 2.3) (p<0.001). The breast milk group had 6.195 times more pain than the swaddling+expressed breast milk, while the facilitated tucking group had 6.301, the facilitated tucking+expressed breast milk group had 3.107, the control group had 13.015, and the swaddling group had 7.892 times more pain. Conclusion: The swaddling+expressed breast milk method is clinically better pain relief nonpharmalogical option and is the recommended method to nurses for the orogastric tube insertion procedures, preterm infants.
AtıfScopus49WoS40OpenAlex71İncele - MakaleYalnız künye2019Scopus SJRQ2Psychrotolerant bacteria isolated from the leaf apoplast of cold-adapted wild plants improve the cold resistance of bean (Phaseolus vulgaris L.) under low temperature
Tiryaki, Deniz; Aydın, İhsan; Atıcı, Ökkeş
We have isolated psychrotolerant bacteria from the leaf apoplast of cold-adapted wild plants and aimed to investigate their effect on the cold resistance of bean (Phaseolus vulgaris L.). Based on the findings of 16S rRNA gene sequence analysis, 20 isolates belonging to 5 bacteria species (Pseudomonas fragi, P. chloropaphis, P. fluorescens, P. proteolytica and Brevibacterium frigoritolerans) were identified in the leaf apoplastic fluid of Draba nemorosa, Galanthus gracilis, Colchicum speciousum, Scilla siberica, Erodium cicutarium, respectively. We have determined that 6 of the 20 isolates have exhibited ACC (1-aminocyclopropane-1-carboxylate) deaminase activity and secreted different extracellular proteins under cold condition (+4 °C) compared to normal growth condition (28 °C). The six isolates were then inoculated independently of each other to the leaves of 10-day-old bean seedlings growing under normal conditions (25/22 °C, 16/8 h photoperiod), and the inoculated and uninoculated (control) seedlings were transferred to cold (9/5 °C, 16/8 h photoperiod) for 3 days. The bacterial inoculations have decreased freezing injury, ice nucleating activity and lipid peroxidation content in parallel with the decrease of reactive oxygen species level such as O2.- and H2O2 in the inoculated seedlings compared to the control. In addition, the inoculations of the isolates have stimulated the activity of apoplastic antioxidant enzymes including superoxide dismutase, catalase, peroxidase, and glutathione reductase. The results show that the inoculations improve the cold resistance of bean seedlings and the psychrotolerant bacterial isolates can be evaluated within the group of plant growth promoting bacteria (PGPB) which can increase tolerance of cold-sensitive crops.
AtıfScopus92WoS66OpenAlex98İncele - MakaleYalnız künye2019Scopus SJRQ1Ethical sensitivity, burnout, and job satisfaction in emergency nurses
Palazoğlu, Cansu Atmaca; Koç, Zeliha
Background: Rising levels of burnout and decreasing job satisfaction can inhibit healthcare professionals from providing high-quality care due to a corresponding decrease in their ethical sensitivity. Aim: This study aimed to determine the relationship between the level of ethical sensitivity in emergency service nurses and their levels of burnout and job satisfaction. Research design: This research employed a descriptive and cross-sectional design. Participants and research context: This study was conducted with a sample of 236 nurses, all of whom worked in emergency service between 24 July 2015 and 28 April 2016. Data were collected using the Moral Sensitivity Questionnaire, Maslach Burnout Inventory, and Minnesota Job Satisfaction Scale. Ethical considerations: This study was approved by the Institutional Ethics Review Board of Ondokuz Mayıs University. Findings: There was a weak and negative correlation (r = –0.158, p = 0.015) between Moral Sensitivity Questionnaire and Maslach Burnout Inventory scores. There was also a weak and negative correlation (r = –0.335, p < 0.001) between the Maslach Burnout Inventory and Minnesota Job Satisfaction Scale scores. Discussion and conclusion: Decreased job satisfaction and increased burnout levels among emergency service nurses might result in them indulging in improper practices, frequently facing ethical problems, and a decrease in the overall quality of service in hospitals. In order for emergency service nurses to recognize ethical problems and make the most accurate decisions, a high level of ethical sensitivity is critical. In this respect, it is suggested that continuing education after graduation and training programs should be organized.
AtıfScopus73WoS64OpenAlex86İncele - MakaleYalnız künye2019Scopus SJRQ1A novel endo-β-1,4-xylanase from Pediococcus acidilactici GC25; purification, characterization and application in clarification of fruit juices
Adiguzel, Gulsah; Faiz, Ozlem; Sisecioglu, Melda; Sari, Bilge; Baltaci, Ozkan; Akbulut, Sumeyya; Genc, Berna; Adiguzel, Ahmet
A novel extracellular xylanase was purified and characterized from Pediococcus acidilactici GC25 (GenBank number: MF289522). The purification was 4.6-fold with a yield of 43.61% through acetone precipitation, Q-Sepharose, and CM-Sepharose ion change chromatography. The molecular weight of the enzyme was 48.15 kDa, and the optimum pH and temperature were 7.0 and 40 °C, respectively. The maximum activity was observed between 20 and 50 °C. Although it was active within a wide pH range (pH 2.0–9.0), it retained over 85% of its activity after 24 h incubation; and over 70% of its activity after 168 h incubation in neutral and alkaline pH. It was observed that the enzyme showed high stability with K+, Ba2+, Cd2+, Co2+, Sr2+, Mg2+, Ca2+, Al3+, Zn2+, and Ni2+ ions. The Km and Vmax for the xylanase were 3.10 mg mL−1 and 4.66 U/mg protein, respectively. It was determined that treatment of different fruit juices with P. acidilactici GC25 xylanase improved the clarification. The highest increase in the reducing sugar amount and decrease in the turbidity was 24.47 ± 1.08 and 21.22 ± 0.58 for peach juice at 0.15 U/mL enzyme concentration. These results showed that the xylanase purified from P. acidilactici GC25 may have a wide potential in biotechnological processes of the food and baking industry.
AtıfScopus61WoS47OpenAlex61İncele - MakaleAçık Erişim2019Scopus SJRQ1Application of multi pass high pressure homogenization to improve stability, physical and bioactive properties of rosehip (Rosa canina L.) nectar
Saricaoglu, Furkan T.; Atalar, Ilyas; Yilmaz, Volkan A.; Odabas, Halil I.; Gul, Osman
The effect of high pressure homogenization (HPH) on physical and bioactive properties of rosehip nectar was investigated. Rosehip nectar has a sedimentation problem while waiting on the market shelf during the sale, for solving this problem, nectars were passed 1, 2 and 3 times through 75, 100 and 125 MPa pressures. Mean particle size decreased as pressure and pass number increased (p < 0.05), whereas zeta potential did not change (p > 0.05). Microstructural images revealed that HPH treatment disrupted the cells and caused to release of cell materials to serum. HPH treatment increased the ΔE values (from 2.48 to 6.03). HPH treated samples showed no sedimentation during storage for 15 days. All samples showed shear thinning behavior and were characterized as weak gel network (G′ > G″). Total phenolic content and ascorbic acid results were decreased by HPH treatments due to increasing outlet temperatures of product, however, antioxidant capacity of nectars increased after treatment due to increasing total carotenoid content. This study indicated that HPH treatment could solve the sedimentation problem during shelf life with minimally affecting bioactive and physical properties of rosehip nectar.
AtıfScopus49WoS39OpenAlex54İncele - MakaleAçık Erişim2019Scopus SJRQ2The Impact of Education About Cervical Cancer and Human Papillomavirus on Women's Healthy Lifestyle Behaviors and Beliefs: Using the PRECEDE Educational Model
Koç, Zeliha; Özdeş, Emel Kurtoǧlu; Topatan, Serap; Çinarli, Tuǧba; Şener, Asuman; Danaci, Esra; Palazoǧlu, Cansu Atmaca
Background Early detection of cervical cancer improves the chances of successful treatment. Objective The aim of this study was to determine the effect of education about cervical cancer and human papillomavirus on the healthy lifestyle, behavior, and beliefs of Turkish women who were without cancer, using the PRECEDE education model. Methods This qualitative and quantitative study was conducted as a prospective, randomized, 2-group (intervention and control) trial at a community training center in north Turkey. A total of 156 Turkish women who were without cancer participated in this study. The semistructured interview form, the SF-36 Health Status Questionnaire, the Health Belief Model Scale for Cervical Cancer and Pap Smear Test, and the Healthy Lifestyle Behavior Scale II were used. Results The subdimension scores of the Health Belief Model Scale for Cervical Cancer and Pap Smear Test were found to be higher among women in the study group (cervical cancer seriousness, P =.001; health motivation, P =.001) as compared with the control group after the education program. The SF-36 Health Status Questionnaire domain scores for physical role limitations, mental role limitations, and general health perceptions increased in the study group after the intervention. Conclusion The posteducation health motivation of women in the study group was improved, the women's perceptions of obstacles to Papanicolaou testing decreased, and through increased knowledge and awareness, the rate of Papanicolaou testing increased. Implications for Practice Educational programs aimed at motivating women to increase their awareness of cervical cancer, preventing cervical cancer, and having Papanicolaou testing are necessary and beneficial in this sample.
AtıfScopus30WoS30OpenAlex34İncele - MakaleYalnız künye2019Scopus SJRQ2Dimethyl Sulfoxide Extract of Dianthus carmelitarum Induces S Phase Arrest and Apoptosis in Human Colon Cancer Cells
Turan, Ibrahim; Demir, Selim; Aliyazicioglu, Rezzan; Kilinc, Kagan; Ozer Yaman, Serap; Akbulut Cakiroglu, Kubra; Kanbolat, Seyda; Ayazoglu Demir, Elif; Mentese, Ahmet; Aliyazicioglu, Yuksel
Although several studies have investigated the cytotoxic effects of different Dianthus species, there has been only limited research into the cytotoxic effect of Dianthus carmelitarum. The purpose of this research was to evaluate the phenolic characterization and the cytotoxic effect of D. carmelitarum on human colon cancer (WiDr) cells and the possible mechanisms involved. Total polyphenolic contents (TPC) and phenolic characterization of the extract were evaluated using the Folin-Cioceltau method and reversed-phase high performance liquid chromatography (RP-HPLC), respectively. The cytotoxic activity of the extract was determined using the methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay. The mechanism involved in the extract’s cytotoxic effect was then evaluated in terms of apoptosis and the cell cycle using flow cytometry, while mitochondrial membrane potential (MMP) was investigated using the fluorometric method. The TPC value of the extract was 784.8 ± 40.3 mg gallic acid equivalent per 100 g sample, and sinapic acid and benzoic acid were detected as major phenolics in the extract. D. carmelitarum extract exhibited a selective cytotoxic effect (3.6-fold) on WiDr cells compared to normal colon cells. The extract induced cell cycle arrest at the S phase and apoptosis via reduced MMP in WiDr cells. Phytomedical and nutraceutical applications of D. carmelitarum may represent promising approaches in the treatment of cancer.
AtıfScopus12WoS13OpenAlex15İncele - Derleme MakaleAçık Erişim2019Scopus SJRQ2The importance of antioxidants and place in today’s scientific and technological studies
Zehiroglu, Cuma; Ozturk Sarikaya, Sevim Beyza
Antioxidants have become scientifically interesting compounds due to their many benefits such as anti-aging and anti-inflammatory. Today, it is still used in many areas. In food technology, antioxidants are added to many foodstuffs in order to enrich the foods and eliminate the problems. Therefore, studies to determine the antioxidant activities of natural foods and their components are also continuing rapidly. Antioxidants have also been replaced in the encapsulation studies used for the preservation and stabilization of food components. Of course, preservation of foods is as important as their production. The latest packaging techniques for food preservation are edible films and coatings. The protective function of edible films and coatings can be improved by the addition of antioxidants. Unlike these, studies on plants and animals have been investigated in vivo in terms of how the antioxidant activity changes as a result of metabolic activities. The role of antioxidant enzymes in these studies is quite large. Many results have been found for the elimination of diseases by either in vivo or in vitro studies regarding antioxidants. Thus, the importance of antioxidants increased with the use in pharmacology, cosmetics and medicine. In this study, we tried to bring a current perspective to antioxidants played an active role in many fields by combining the technological applications and scientific studies of antioxidants. In order to further customize the issue, we have done this especially for the food and health field and we have tried to emphasize the importance of antioxidants in this way.
AtıfScopus252WoS190OpenAlex273İncele - MakaleAçık Erişim2019Scopus SJRQ3Employees’ opinions on critical success factors and performance criteria in disaster and emergency management
Sahinoz, Saime; Yaprak, Unal; Sahinoz, Turgut
Objective: To evaluate the critical success factors at disaster and emergency management and to analyse their impact on performance to guide the managers and decision makers. Methods: This was a cross-sectional study. It included all staff working in the fire brigade, 112 Emergency, Disaster and Emergency Management Authority and Red Crescent institutions serving in emergency situations in five provinces (Rize, Artvin, Trabzon, Gümüşhane, Bayburt) in the Eastern Black Sea region of Turkey. One province (Gümüşhane) was selected by cluster sampling method. Questionnaire which is the data collection method in the study was applied between 08/01/2016-02/02/2016 to all of the staff working in the fire brigade, 112 Emergency, Disaster and Emergency Management Authority and Red Crescent institutions serving in emergency situations in Gümüşhane province. Results: It has been found out that there is a significant and positive relationship between all of the critical success factors, planning, response and recovery criteria, and performance variance. Conclusions: The presence of well-planned emergency aid systems in the institutions or organizations involved in this area is an element of success. For this reason, this factor should be given more importance.
AtıfScopus2WoS2OpenAlex2İncele - MakaleYalnız künye2019Scopus SJRQ1Examining the effect of “Shotblocker” in relieving pain associated with intramuscular injection
Aydin, Esra; Avşar, Gülçin
This study was conducted in order to examine the effect of “Shotblocker” in relieving pain associated with intramuscular injection. The population of the study consisted of all the patients who were hospitalized in the hospital and received intramuscular diclomec treatment. In order to eliminate the individual pain differences, each patient constituted their own control group. Patient Information Form, Visual Analogue Scale (VAS), and Shotblocker were used to collect the data. Pain level of the patients was measured by using VAS within the first minute after the injection. The pain mean score of the patients was 1.22 ± 0.62 in the experimental group and 2.48 ± 1.12 cm in the control group and the difference between them was statistically significant (p < 0.001). Shotblocker was determined to be effective on relieving pain associated with intramuscular injection.
AtıfScopus29WoS21OpenAlex32İncele - MakaleYalnız künye2019Scopus SJRQ1Effects of Kefir on Quality of Life and Sleep Disturbances in Postmenopausal Women
Özcan, Handan; Oskay, Ümran; Bodur, Ali Fuat
The aim of this study is to identify the effects of kefir, an alternative treatment method, on quality of life and sleep disturbances in postmenopausal women. In this study, it is seen that kefir has positive effects on sleep disturbances, depression, and quality of life in postmenopausal women.
AtıfScopus19WoS17OpenAlex22İncele