Yazarlar
- Uzun, Sevda(79)
- Kulakaç, Nurşen(40)
- Turan, Ibrahim(33)
- Demir, Selim(32)
- Türkkan, Tuğba(24)
- Aydin, Aydanur(23)
- Topal, Fevzi(22)
- Aliyazicioglu, Yuksel(21)
- Tuncer, Metin(21)
- Bayrakdaroglu, Serdar(19)
- Demirağ, Hatice(19)
- Hintistan, Sevilay(18)
- Topal, Meryem(18)
- Yılmaz, Coşkun(18)
- Bayrakdaroğlu, Serdar(15)
- Yilmaz, Coskun(15)
- Mentese, Ahmet(14)
- Reis, Hatice Catal(14)
- Demir Doğan, Melike(13)
- Emirza, Elif Güzide(13)
- Memetoglu, Mehmet Erdem(13)
- Tuncer, Gülsüm Zekiye(13)
- Bülbül, Kenan(12)
- Cin, Aynur(12)
- Düzgün, Azer Özad(12)
- Koçak, Tevfik(12)
- Odaci, Hatice(12)
- Oğuzhan, Hatice(12)
- Tonkaz, Duygu Erkal(12)
- Tonkaz, Mehmet(12)
- Turk, Veysel(12)
- Ceylan, Halil Ibrahim(11)
- Kilinc, Kagan(11)
- Köse, Aslı(11)
- Merdan, Mehmet(11)
- Acet, Tuba(10)
- Aksoy, Bahar(10)
- Aydin Sayilan, Aylin(10)
- Baltaci, Cemalettin(10)
- Deger, Orhan(10)
Yayınlar
- MakaleAçık Erişim2018Babalar ve Gebelik Süreci
Özcan, Handan; Çakır, Abdullah; Arar, İbrahim
Amaç: Çalışma, Gümüşhane’de yaşayan babaların, gebeliksürecinde yaşadıkları duygular ve eşlerine destek olma durumlarınıbelirlemek amacıyla planlanmıştır.Gereç ve Yöntemler: Araştırma tanımlayıcı niteliktedir. Çalışmaevrenini Gümüşhane Devlet Hastanesine başvuru yapanbabalar, örneklemi ise 15.02.2017-15.03.2017 tarihleri arasındaulaşılan ve çalışmaya gönüllü olarak katılmayı kabul edenbabalar oluşturmuştur (N:400). Verilerin analizinde frekans veki kare testleri kullanılmıştır.Bulgular: Babaların yaş ortalaması 44,11±10,55’dir. Katılımcıların%54.2’si baba olduğunu duyunca çok heyecanlandığını,%34.5’i ise çok gururlu olduğunu ifade etmiştir. Katılımcıların%65.5’i gebelik kontrollerine eşle birlikte gittiğini, %76.4’ü gebeliksürecinde ev işlerinde eşlerine yardım ettiklerini, %41.4’ü anneyekarşı empatik yaklaştığını, %79.8’i annenin yaşadığını fizyolojikdeğişikliklerden rahatsız olmadığını ifade etmiştir. Babaların%41.8’i gebelik ve doğum sürecinde babalık rolünü en çok bebeğiilk defa kucaklarına aldıklarında hissettiklerini belirtmişlerdir.Babaların %54.1’inin doğum süreciyle ilgili herhangi bir eğitimalmadıkları belirlenmiştir. Ailelerin gelir durumunun artmasıyla,gebelik döneminde erkeklerin eşlerine daha fazla empatikyaklaştıkları bulunmuştur. Yine eğitim durumunun artmasıile erkeklerin eşle birlikte kontrollere daha fazla gittiği, bebekbakımı ve gebelik sürecinde eşlere daha fazla destek olduklarıayrıca eşle bu sürecin daha fazla paylaşıldığı belirlenmiştir.Sonuç: Gebelik ve doğum sırasında babaların sürece katılımı,çocukların daha iyi zihinsel-sosyal-emosyonel gelişime ve maternalsağlığın iyileşmesine sebep olmaktadır. Sağlıklı bir toplumve gelecek için prenatal sürece babanın da dahil edilmesigerekmektedir.
- MakaleAçık Erişim2018Competencies of Healthcare Managers in Public Hospitals
Köse Ünal, Aslı; Aydoğan, Enver
Competencies are becoming more important for healthcare organizations. The aim of this study is to determine the managerial competencies of healthcare managers. In this study, a questionire prepared by using Healthcare Executives Competencies Assessment Tool which was translated to Turkish by Erigüç, Kurul ve Tekin Numanoğlu 2014). ACHE for the purpose of using self-assessment tool for healthcare managers. The questionnaire have been applied a total of 400 healthcare managers in public hospitals. From the competencies of the healthcare managers, who participated in the research, competency level of leadership is determined as the highest area of competency while level of knowledge in healthcare sector is the lowest area of competency. Knowledge level of the healthcare managers having different job roles in healthcare sector is the lowest area of competency because 82% of the healthcare managers did not receive the training on healthcare management. A statistical significance between the competencies and managerial statuses of the healthcare managers within the scope of the research could not be found. When the differences in the competency areas according to genders of the healthcare managers are evaluated, it is determined that communication and interpersonal relations management competency level of female managers is higher than the level of male managers.
- MakaleAçık Erişim2018Picea orientalis kozalağının antioksidan ve antiradikal özelliklerinin belirlenmesi
Topal, Meryem
Metabolizmada oluşan reaktif oksijen türleri engellenmediği sürece, DNA, protein, karbohidrat ve lipitlerde yapısal bozulmalar meydana getirir. Buna bağlı olarak hücre membranının hem stabilizesi ve hem de fonksiyonları bozulur ve birçok dejeneratif hastalıklar meydana gelir. Önceki çağlarda insanlar sağlık sorunlarını çözmek için de bitkisel tedavilere başvurmuştur. Günümüzde özellikle bilimsel olarak çalışmalar artmış özellikle alternatif tıp olarak da yaygınlık göstermiştir. Fenolik bileşik içeren bitkiler doğal antioksidan olarak genellikle kullanılmaktadır. Bu bileşikler serbest radikallerin yol açtığı reaksiyonları durdurarak veya engelleyerek kalp, kanser, ve akciğer hastalıkları gibi hastalıkların oluşumuna engellerler. Antioksidanlar, biyomoleküllerin oksidasyonunu engelleyen veya tamamen durduran maddeler olarak bilinir ve oldukça yaygın bir kullanım alanına sahiptirler. Doğu ladin, çamgiller familyasında bulunan bilimsel adı P. orientalis’dir. Yapılan bu çalışmada doğu ladin kozalağının etanol ekstreleri kullanılarak antioksidan kapasitesinin belirlenmesi hedeflenmiştir. Bu amaçla demir indirgeme kapasiteleri ve bakır indirgeme kapasiteleri, ABTS radikal giderme aktiviteleri ve DPPH radikal giderme aktiviteleri, total fenolik bileşik miktarlarını ve flavonoit bileşik miktarlarını belirleme gibi in vitro şartlarda farklı biyoanalitik metotlar ile antioksidan ve antiradikal özellikleri belirlendi. P. orientalis kozalağının DPPH radikal giderme aktivitesi için IC 50 değeri 24,75 μg mL -1 , ABTS radikal giderme aktivitesi için ise 13,42 μg mL -1 olarak tespit edildi. Buna göre yapılan metotlarda yüksek antioksidan kapasitesine sahip olduğu belirlendi.
- MakaleAçık Erişim2018Antidiabetic Potential: Effect of Resorcinol on α-Glycosidase and α-Amylase Enzymes
Topal, Fevzi
The vast majority of the carbohydrates in the biomolecule class are formed by photosynthesis using sunlight. One of the important enzymes in this class is α-glycosidase. This enzyme converts complex carbohydrates to monosaccharides. On the other hand, another important enzyme species is the α-amylase enzyme. Which directly related to starch. Starch is a type of polymer formed by the oxygen binding of glucose units to each other at the C1 position with glycosidic bonds. α-Amylase is an enzyme that catalyzes the hydrolysis of glycosidic bonds in starch, and this enzyme is purified from a wide variety of animals, plants, and microorganisms. Resorcinol, a phenol derivative, is an important organic chemical substance in the production of textile, medicine, hair dye, plastic and agricultural products of many industrial materials. Resorcinol, a phenol derivative, is present as white crystals, and resorcinol consists of two hydroxyl molecules attached to the benzene ring, and also was defined as α-glycosidase and α-amylase inhibitor to detect antidiabetic properties. Resorcinol was used as 𝛼-glycosidase and 𝛼-amylase inhibitor. Accordingly, IC50 values of α-amylase and α-glycosidase were calculated as 1.34 μM and 77.00 nM, respectively. On the other hand, Ki value for α-glycosidase was found as 30.16 nM. It has been observed that α-amylase and α-glycosidase enzymes can inhibit by resorcinol compound. It has the properties of inhibiting carbohydrate absorption by inhibiting α-glycosidase enzymes in the small intestine. For both metabolic enzymes, resorcinol may be preferred as an inhibitor. In this case, resorcinol may be used as an inhibitor against to healty problems like Diabetes mellitus and antiobesity.
- MakaleAçık Erişim2018Investigation of Antibiotic Resistance Genes and Class 1 Integron in Multi-Drug Resistant P. aeruginosa and E. coli Strains
Sarıyer, Aysegül Saral; Düzgün, Azer Özad
P. aeruginosa and E. coli are resistant to many antibiotics, so the treatment of infections of these pathogens has become difficult. Therefore, searching for the presence of antibiotic resistance genes in clinical isolates is of great importance. The purpose of this study is to investigate the presence of beta-lactam resistance genes and class 1 integron in multi-drug resistant P. aeruginosa and E. coli clinical strains. Vitek 2 Compact automatization system were used for identification and antibiogram of 2 P. aeruginosa and 2 E. coli isolates which were isolated from blood, urine and sputum specimens of patients whom were hospitalized in Gümüşhane State Hospital intensive care unit. Total DNA isolation was done by boiling DNA method. PCR were performed using primers of class 1 integron gene cassette, blaVIM, blaNDM, blaIMP, blaGES, blaCTXM-1, blaCTXM-2, blaOXA-58, blaOXA-23, blaOXA-51, blaOXA-40 and blaKPC. All amplification samples were performed on 1% agarose gel and subsequently visualized under UV light. According to the results of the antibiogram, P. aeruginosa isolates showed resistance against all used antibiotics except gentamicin. The E. coli isolates were found to be resistant to cephalosporin antibiotics and susceptible to carbapenems. blaCTXM-1-class A beta lactamase genes was found in 3 strains of 4, while no blaCTXM-2, blaGES and blaKPC genes were detected in the strains. The presence of the investigated class B and class D beta lactamase genes was not observed in any sample. The presence of class 1 integron was detected in 3 strains. According to the result of the DNA sequence analysis, it was determined that three integron positive samples had the dfrA1/AadA5 gene cassettes.
- MakaleAçık Erişim2018The Detection of the Relationship Between Depression and Malnutrition in Cancer Patients
Ünlü, Ayşe; Sancar Bekircan, Esra
Objective: The disease of cancer and the treatments administered might cause malnutrition and depression in patients. This research aims to assess the risk of depression and malnutrition in cancer patients and analyse the relationship between two diseases. Material and Method: The supplementary research conducted face-to-face interview method with 82 patients who applied to Gaziantep University Şahinbey Research and Application Hospital with cancer diagnosed and Adult Oncology Clinic and Polyclinic between the dates 4 April-4 September 2018 and volunteered to participate in the research. Depression case was assessed with Beck’s Depression Inventory (BDI) and nutrition cases were assessed with Nutrution Risk Screening (NRS2002). SPSS 17 (Statistical Package for the Social Sciences) programme was used to anaylse the data. Results: Participants received 28.98±10.10 points on average. According to the scores of the participants, 37.8% percent of them have moderate depression. They received 2.22±0.72 points on average from NRS-2002. It was revelaled that 43.9% percent of the participants had moderate malnutrition. A further analysis (LSD) conducted to detect which depression level the difference resulted from showed that NRS-2002 scores of the participants with severe depression are higher than the ones with moderate mood disorders, clinical depression and moderate depression. According to BDI, the difference between NRS-2002 scores is statistically meaningful. Furthermore, it has been revealed that the NRS-2002 scores of the participants with severe depression are higher than the ones with moderate mood disorders, clinical depression and moderate depression. Conclusion: The problems of oncologic patients related to nutrition and depression should be diagnosed earlier and treated soon.
- MakaleAçık Erişim2018Güç motivasyonunun iş sevgisine etkisinde geribildirim arama davranışının düzenleyici rolü
Aslan, Sevil; Antalyalı, Omer Lütfı
Bu çalışmanın amacı, güç motivasonuyla iş sevgisi ilişkisinde geribildirim arama motivasyonlarının düzenleyici rolünün araştırılmasıdır. Alanda yapılan çalışmalarda, çalışanların iş sevgisinin birçok etmenin yanında temel motivasyon kaynakları ve geribildirim arama motivasyonlarıyla ilişkili olduğu görülmüştür. İşyerinde var olan performansla ilgili bilgilere erişimi sağlayan geribildirim arama, belirsizliklerin azalmasında etkili olduğundan iş sevgisiyle oldukça ilişkilidir. Bunun yanında, bireyin etkin olma isteğini niteleyen güç ihtiyacının karşılanması sonucunda iş sevgisinin pozitif yönde etkilendiği bilinmektedir. Buradan hareketle bu çalışmada, bireylerin güç motivasyonlarının iş sevgisine etkisi ve geribildirim arama motivasyonlarının bu ilişkideki rolüne odaklanılmıştır. Bu amaçla çalışma, özel hastanelerde çalışan 219 hemşireye ulaşılarak gerçekleştirilmiştir. Katılımcıların temel motivasyon kaynakları, iş sevgileri ve geribildirim arama davranışlarını ölçmek amacıyla 3 farklı ölçekten oluşan anket kullanılmıştır. Anket sonucunda elde edilen veriler SPSS ve AMOS programlarıyla analiz edilerek değerlendirmeye tabi tutulmuştur. Analiz sonucunda hemşirelerin geribildirime kayıtsızlık düzeyinin, güç motivasyonunun iş sevgisine etkisinde düzenleyici rolü olduğu saptanmıştır. Buna göre bireyin geribildirime kayıtsızlık düzeyi arttıkça güç ihtiyacının iş sevgisine etkisinin artış gösterdiği tespit edilmiştir. Buna karşın geribildirime defansif yaklaşma düzeylerinin, güç motivasyonunun iş sevgisine etkisinde herhangi bir etkisinin olmadığı görülmüştür.
- MakaleAçık Erişim2018Ergonomic risk perception of women working in metal industry: a survey
Aytaç, Sevinç Serpil; Tüfekçi, Ülviye; Gökçe, Ahmet; Yamankaradeniz, Nurettin; Akalp, Hüsre Gizem; Cankaya, Oguzhan; Özok, Ahmet Fahri
In this study, it is aimed to evaluate the ergonomic risk perceptions of women working in metal industry in terms of Occupational Health and Safety. For this purpose, 1918 female workers working in the metal industry in our province were measured by ergonomic risk perception, fatalism perception and safety awareness in a workplace. In this questionnaire, using the scale of ergonomic risk perception created by the researchers, the scale of security awareness and fatalism used in other studies were used. The data were analyzed by using SPSS package program and their perceptions about ergonomic risks were analyzed by using factor analysis, correlation and t tests. In this study, musculoskeletal problems emerged as the first priority in women workers as ergonomic risk factors by considering the characteristics of women's work.
- MakaleAçık Erişim2018Investigation of lsepamicin, Chloramphenicol and Minocycline Sensitivity in Carbapenem-Resistant Enterobacteriaceae
Karakullukçu, Asiye; Borsa, Baris Ata; Kuskucu, Mert Ahmet; Bakir, Esra; Taner, Zeynep; Özalp, Veli Cengiz; Aygün, Gokhan
Objective: In this study, we aimed to determine the resistance mechanisms of carbapenem-resistant Enterobacteriaceae (CRE), and evaluate the prospective alternative treatment options. Methods: Between October 2014 and July 2015, rectal swabs routinely obtained from hospitalized patients were included in the study. The isolated Gram-negative enteric bacteria were identified to the species level by using standard conventional microbiological methods. Determined carbapenem resistance in enteric bacteria was confirmed by using meropenem Etest (R) (bioMerieux, Marcy l'Etoile, France), and the resistance mechanisms were investigated with MAST-ID (TM) Discs (Mast Diagnostics Ltd, Bootle, Merseyside, UK). Antibiotic susceptibilities of the CRE were determined by disk diffusion method using isepamicin, chloramphenicol, and minocycline disks (Oxoid, Basingstoke, Hampshire, UK). Results: Of the 3,323 rectal swabs sent to the laboratory during the study period, totally 84 (2.5%) CRE were isolated with one strain from each patient. Of the 84 CRE, 74 (88%) were Klebsiella pneumoniae and 10 (12%) were Escherichia coli. Among the 84 CRE, 66 (78.5%) with OXA-48, 11 (13.1%) with OXA48 + metallo-beta-lactamase (MBL), 1 (1.2%) with only MBL and 1 (1.2%) with AmpC + porin loss were detected, none of the strains were positive for KPC. In 5 (6%) strains, none of the resistance mechanisms were found. Of the 84 CRE, 80 (95.2%), 77 (91.6%) and 14 (16.6%) were found to be susceptible to isepamicin, chloramphenicol and minocycline, respectively. Conclusions: The OXA-48 type, endemic in Turkey, was also the most commonly detected carbapenemase in the study. It has been observed that isepamicin and chloramphenicol can be the potential antibiotics in the treatment of KDE-related infections.
- MakaleYalnız künye2018Evaluation of acute kidney injury (AKI) with RIFLE, AKIN, CK, and KDIGO in critically ill trauma patients
Ülger, F.; Küçuk, M. Pehlivanlar; Kucuk, A. O.; Ilkaya, N. K.; Murat, N.; Bilgiç, B.; Abanoz, H.
The aim of our study was to evaluate the effects of AKI development on mortality with four different classification systems (RIFLE, AKIN, CK, KDIGO) in critically ill trauma patients followed in the intensive care unit. A retrospective review of 2034 patients in our intensive care unit was conducted between July 2010 and August 2013. A total of 198 patients with primary trauma were included in the study to evaluate the development of AKI. When the presence of AKI was investigated according to the four criteria (RIFLE, AKIN, CK, and KDIGO), the highest incidence of AKI was found according to the KDIGO classification (74.2%), followed by AKIN (72.2%), RIFLE (69.7%), and CK (59.1%). It was observed that more AKI developed according to KDIGO in patients with multiple trauma and thoracic trauma (p = 0.031, p = 0.029). Sixty-two (31%) of the 198 trauma patients monitored in the intensive care unit died; mortality was frequently found high in AKI stage 2 and 3 patients. According to the CK classification, there was a significant increase in mortality in patients with AKI on the first day (p = 0.045). AKI classifications by RIFLE, AKIN, CK, and KDIGO were independently associated with the risk of in-hospital death. In this study, the presence of AKI was found to be an independent risk factor in the development of in-hospital mortality according to all classification systems (RIFLE, AKIN, CK, and KDIGO) in critically traumatic patients followed in ICU, and the compatibility between RIFLE, AKIN, and KDIGO was the highest among the classification systems.
- MakaleAçık Erişim2018Are extramedian symptoms associated with peripheral causes in patient with carpal tunnel syndrome? Electrodiagnostic and ultrasonographic study
Mansiz-Kaplan, Basak; Akdeniz-Leblecicier, Merve; Yagci, Ilker
Objective: To evaluate the relationship between extramedian spreading of sensorial symptoms and median and ulnar nerve cross-sectional area (CSA) and to compare the ultrasonographic and electrophysiological findings in patients with carpal tunnel syndrome (CTS) with or without extramedian sensory symptoms. Design: Cross-sectional study. Materials and methods: Patients with CTS were divided into two groups as with or without extramedian symptoms and were assessed clinically, electrophysiologically and ultrasonographically by three blind investigators. In electrophysiological tests, median and ulnar nerve conduction studies were performed. Nerve cross-sectional areas were measured at hook of hamate, psiform bone, radio-ulnar joint, one-third distal part of forearm, and medial epicondyle by ultrasonography. Findings: The study was completed with 61 patients (108 hands). Extramedian symptoms were present in 31 patients (54 hands). Finger grip strength was lower, pain values evaluated with visual analogue scale were higher in patients with extramedian symptoms (p < 0.05). There was no statistically significant difference in electrophysiological and ultrasonographic parameters. Conclusion: According to our results, extramedian symptoms are not related to nerve conduction studies or nerve ultrasonography, these symptoms may be explained with central sensitization in patient with CTS. (C) 2017 Elsevier Ltd. All rights reserved.
- EditoryalAçık Erişim2018A rare coincidence of hypoplasia of the posterior mitral leaflet and the bicuspid aortic valve
Demirel, Muhittin; Acar, Emrah; Sivri, Serkan; Sökmen, Erdogan; Özbek, Sinan Cemgil
- MakaleAçık Erişim2018Comparison of Different Dynamic Contrast Enhanced-Magnetic Resonance Imaging Descriptors and Clinical Findings Among Breast Cancer Subtypes Determined Based on Molecular Assessment
Dogan, Serap; Ozmen, Soner; Oz, Bahadir; Imamoglu, Hakan; Kahriman, Guven; Zararsiz, Gokmen; Ozturk, Mustafa
Background: Breast cancer is a heterogeneous disease with different molecular and histologic subtypes, clinical behaviors and prognosis. The same stage of disease and similar histopathological characteristics may show different treatment responses. Identification of breast cancer subtypes has become important for planning the targeted therapy and personalized management of patients. Objectives: To compare the clinicopathologic findings, dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) characteristics and associated MRI findings among breast cancer molecular subtypes. Patients and Methods: 267 pathologically proven invasive breast cancers in 263 patients were included. Clinicopathological findings, DCE-MRI findings and associated MRI findings were retrospectively evaluated and compared among breast cancer subtypes. Results: Invasive ductal carcinoma was the most common histological tumor type (87.6%). There were 222 (83.1%) masses and 45 (16.9%) non-mass enhancements. The molecular subtypes were luminal A in 174 (65.1%), luminal B in 45 (16.9%), human epidermal growth factor receptor 2 (HER2) positive in 24 (9%) and triple negative (TN) in 24 (9%) of the lesions. Spiculated mass margin was significantly associated with luminal A breast cancer (45.2%) and irregular shape was significantly more common in luminal A (86.3%) and luminal B lesions (95.1%) (P < 0.001). Larger mass size (P= 0.027), non-mass enhancement (P= 0.005), perilesional+ prepectoral edema and skin + perilesional+ prepectoral edema were significantly associated with HER2 positive breast cancer (P= 0.001). Higher histological grade, oval mass shape, circumscribed mass margin, intratumoral high/very high signal intensity on T2 weighted image (T2WI) were significantly associated with TN breast cancer (P < 0.001). Conclusion: Histological grade, size and morphological features of masses on DCE-MRI, intratumoral signal intensity on T2WI and edema pattern would be helpful to distinguish breast cancer subtypes.
- MakaleAçık Erişim2018Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression
Turan, Ibrahim; Demir, Selim; Kilinc, Kagan; Yaman, Serap Ozer; Misir, Sema; Kara, Hanife; Genc, Berna; Mentese, Ahmet; Aliyazicioglu, Yuksel; Deger, Orhan
Rosa canina is a member of the genus Rosa that has long been used for medical objectives. Several studies have reported cytotoxic effects of different Rosa species, but there has been only limited investigation of the cytotoxic effect of R. canina. The purpose of the current study was to examine the potential effect of R. canina extract on cell viability, the cell cycle, apoptosis, and the expression of telomerase in human colon cancer (WiDr) cells. The cytotoxic effect of the extract was determined using MTT assay. The mechanism involved in the cytotoxic effect of the extract was then evaluated in terms of apoptosis and the cell cycle using flow cytometry. Mitochondrial membrane potential (MMP) was investigated using the fluorometric method, and expression levels of telomerase were studied using RT-PCR. R. canina extract exhibited a selective cytotoxic effect on WiDr cells compared with normal colon cells. The extract induced cell cycle arrest at the S phase and apoptosis via reduced MMP in WiDr cells. R. canina extract significantly repressed telomerase expressions at treatment times of 48 and 72 h in WiDr cells. Our results suggest that R. canina may have considerable potential for development as a novel natural product-based anticancer agent.
- MakaleAçık Erişim2018Antioxidant properties and protective effect of Turkish propolis on t-BHP-induced oxidative stress in foreskin fibroblast cells
Misir, Sema; Aliyazicioglu, Yuksel; Demir, Selim; Turan, Ibrahim; Yaman, Serap Ozer; Deger, Orhan
Objective: Propolis is an important bee product, rich in polyphenolic compounds. It has antitumoral, antioxidant, antimutagenic, and other useful activities. Biological activities of propolis are generally attributed to its substance of polyphenolic compounds. The aim of this study was to investigate the in vitro antioxidant properties and reduction amount of intracellular reactive oxygen species (ROS) in human normal foreskin fibroblast cells by Turkish propolis ethanolic extract (EEP). Method: Total phenolic and flavonoid contents, reducing power, radical scavenging capacity, and iron chelating activity of EEP were determined using spectrophotometric methods. Intracellular ROS levels were determined by spectrofluorometric analysis with CM-H2 DCFDA. Results: Our results indicated that antioxidant activity was correlated with the higher total phenolic and flavonoid contents of EEP. The generated ROS levels were significantly decreased by EEP compared to only t-BHP group. Conclusion: Ethanolic propolis extract may be evaluated as a potency antioxidant resource and/or a novel natural agent in food and drug industries.
- MakaleYalnız künye2018Prediction of the antimicrobial activity of walnut (Juglans regia L.) kernel aqueous extracts using artificial neural network and multiple linear regression
Kavuncuoglu, Hatice; Kavuncuoglu, Erhan; Karatas, Seyda Merve; Benli, Büsra; Sagdic, Osman; Yalcin, Hasan
The mathematical model was established to determine the diameter of inhibition zone of the walnut extract on the twelve bacterial species. Type of extraction, concentration, and pathogens were taken as input variables. Two models were used with the aim of designing this system. One of them was developed with artificial neural networks (ANN), and the other was formed with multiple linear regression (MLR). Four common training algorithms were used. Levenberg–Marquardt (LM), Bayesian regulation (BR), scaled conjugate gradient (SCG) and resilient back propagation (RP) were investigated, and the algorithms were compared. Root mean squared error and correlation coefficient were evaluated as performance criteria. When these criteria were analyzed, ANN showed high prediction performance, while MLR showed low prediction performance. As a result, it is seen that when the different input values are provided to the system developed with ANN, the most accurate inhibition zone (IZ) estimates were obtained. The results of this study could offer new perspectives, particularly in the field of microbiology, because these could be applied to other type of extraction, concentrations, and pathogens, without resorting to experiments.
- MakaleYayıncıda açık erişim2018Choosing safe and suitable bicycle routes to integrate cycling and public transport systems
Saplıoğlu, M.; Aydın, M.M.
Bicycle utilization has become an important transportation mode in various cities during the past decade. It has brought a rapid growth as an important transport mode in many countries by providing several benefits for traffic, health and cost. However, the growing in bicycle utilization demand causes many problems such as safety, effectiveness etc. For this reason, other effective parameters on urban transport should be considered when planning new safe bicycle paths in the spatial platform. In this study, it was aimed to examine all these negative and positive effective parameters on safety and choice while integrating cycling with a public transport (bus link) system. To determine effective parameters on route choice, a Questionnaire Survey (QS) was carried out on 460 participants who are cycling for a long time in Isparta City/Turkey. It was obtained from the QS that Accident Prone Areas (APA) are the most important factor on cycling and public transport integration. The other parameters are determined as Bus Lane (BL), Road Side Car Park (RSCP), Bicycle Parks (BP), Road Grade (RG), Signalization (S), Traffic Capacity (TC), Connected Bike Lane (CBL) and Separated Bike Lane (SBL) according to their importance. In order to determine safer and serviceable bicycle routes selection problem, accident-prone locations (using Accident Reports and Geographic Information Systems-GIS), bus lines and survey data has been used in GIS. Also, a multi-criteria decision making approach Analytic Hierarchy Process (AHP) method is implemented to analyze survey data and decide effective parameters on safer and serviceable bicycle routes. It was found that safer and serviceable bicycle routes can be determined by the utilization of QS, GIS and AHP methods with together. Also, it was concluded that Accident Prone Areas, Bus Lanes and Road Side Car Parks are the most important factors while integrating cycling with a public transport system.
- MakaleAçık Erişim2018Next-generation sequencing of plasmid carrying blaOXA-48 in Klebsiella pneumoniae from Turkey
Düzgün, Azer Özad; Saral, Ayşegül
A carbapenem-resistant Klebsiella pneumoniae strain was isolated in Turkey in 2012 and blaNDM-1 and blaOXA-48 genes were observed in this strain. The aim of this study was to investigate transferability of plasmid bearing blaOXA-48 in K. pneumoniae and to use whole-genome sequencing in order to understand the genetic context of plasmid. K. pneumoniae strain was used as donor in conjugation experiments. Antibiotic susceptibility profile of selected transconjugant was determined. Plasmid was isolated from transconjugant colony and was named as pKPT. Complete sequencing of the pKPT was conducted using a next-generation sequencing. Annotation of the contigs was performed using the Geneious R9, followed by finding open reading frames (ORFs) with selected web-based tools. BLAST analysis was performed at the NCBI BLAST server to determine genes showing more than 90% similarity with these ORFs. Results of antibiotic susceptibility test showed that transconjugant colony was resistant to ampicillin/ sulbactam, piperacillin, and piperacillin/tazobactam. The pKPT plasmid had a length of 45,217 bp and an average G + C content of 49%. Blast analysis revealed that pKPT was included in the IncL/M incompatibility group. The pKPT was found to contain blaOXA-48 within Tn1999.2 transposon without any other antibiotic resistance gene.
- MakaleYalnız künye2018The effect of reiki on pain: A meta-analysis
Demir Doğan, Melike
Objective: Pain is one of the most common symptoms and may lead to important psychological, mental, and physiological problems in individuals. According to data by The Center for Reiki Research, Reiki is an effective approach to decrease the levels of pain, depression, and anxiety. Therefore, the aim of this meta-analysis was to investigate the effect of Reiki on pain level. Methods: Randomized controlled clinical trials in databases of Pubmed, ISI Web of Sciences, and Google Scholar were investigated. 4 randomized controlled studies involving 212 participants were included in the meta-analysis. Results: The result obtained after the final Reiki application was evaluated in VAS pain score. When Reiki (n = 104) group was compared with control group (n = 108), standardized mean difference was observed to be −0.927 (95% CI: −1.867 to 0.0124). Reiki was observed to cause a statistically significant decrease in VAS score. Conclusion: Consequently, this meta-analysis revealed that Reiki was an effective approach in relieving the pain.
- MakaleAçık Erişim2018The relationship between university students' music preferences and drug abuse tendencies and personality traits
Altun, Zühal Dinç; Bülbül, Kenan; Türkkan, Tuğba
The purpose of this study is to determine whether music preferences differ in terms of drug abuse tendencies and personality traits with regard to the type of music that music teacher candidates listen to. The research group of the study was comprised of 141 university students. Research data were collected using the Substance Use Tendency Scale, the Adjective-Based Personality Test (ABPT), and the Personal Information Form developed by the researchers. Pop music (93.6%) was determined to be the music type most listened to, and Heavy Metal music (21.3%) music the type least listened to. While the students were determining their music preferences, they indicated that the moods (99.3%) and the melody of the music (98.6%) were primarily important. The results of the analysis show that there are significant differences in music preferences based on the tendency for drug abuse and on personality traits. Findings have been discussed in the light of the relevant literature, and proposals have been made to professionals working in the fields of research, music therapy and music education.
