Yazarlar
- Uzun, Sevda(79)
- Kulakaç, Nurşen(40)
- Turan, Ibrahim(33)
- Demir, Selim(32)
- Türkkan, Tuğba(24)
- Aydin, Aydanur(23)
- Topal, Fevzi(22)
- Aliyazicioglu, Yuksel(21)
- Tuncer, Metin(21)
- Bayrakdaroglu, Serdar(19)
- Demirağ, Hatice(19)
- Hintistan, Sevilay(18)
- Topal, Meryem(18)
- Yılmaz, Coşkun(18)
- Bayrakdaroğlu, Serdar(15)
- Yilmaz, Coskun(15)
- Mentese, Ahmet(14)
- Reis, Hatice Catal(14)
- Demir Doğan, Melike(13)
- Emirza, Elif Güzide(13)
- Memetoglu, Mehmet Erdem(13)
- Tuncer, Gülsüm Zekiye(13)
- Bülbül, Kenan(12)
- Cin, Aynur(12)
- Düzgün, Azer Özad(12)
- Koçak, Tevfik(12)
- Odaci, Hatice(12)
- Oğuzhan, Hatice(12)
- Tonkaz, Duygu Erkal(12)
- Tonkaz, Mehmet(12)
- Turk, Veysel(12)
- Ceylan, Halil Ibrahim(11)
- Kilinc, Kagan(11)
- Köse, Aslı(11)
- Merdan, Mehmet(11)
- Acet, Tuba(10)
- Aksoy, Bahar(10)
- Aydin Sayilan, Aylin(10)
- Baltaci, Cemalettin(10)
- Deger, Orhan(10)
Yayınlar
- MakaleYalnız künye2019Ethical sensitivity, burnout, and job satisfaction in emergency nurses
Palazoğlu, Cansu Atmaca; Koç, Zeliha
Background: Rising levels of burnout and decreasing job satisfaction can inhibit healthcare professionals from providing high-quality care due to a corresponding decrease in their ethical sensitivity. Aim: This study aimed to determine the relationship between the level of ethical sensitivity in emergency service nurses and their levels of burnout and job satisfaction. Research design: This research employed a descriptive and cross-sectional design. Participants and research context: This study was conducted with a sample of 236 nurses, all of whom worked in emergency service between 24 July 2015 and 28 April 2016. Data were collected using the Moral Sensitivity Questionnaire, Maslach Burnout Inventory, and Minnesota Job Satisfaction Scale. Ethical considerations: This study was approved by the Institutional Ethics Review Board of Ondokuz Mayıs University. Findings: There was a weak and negative correlation (r = –0.158, p = 0.015) between Moral Sensitivity Questionnaire and Maslach Burnout Inventory scores. There was also a weak and negative correlation (r = –0.335, p < 0.001) between the Maslach Burnout Inventory and Minnesota Job Satisfaction Scale scores. Discussion and conclusion: Decreased job satisfaction and increased burnout levels among emergency service nurses might result in them indulging in improper practices, frequently facing ethical problems, and a decrease in the overall quality of service in hospitals. In order for emergency service nurses to recognize ethical problems and make the most accurate decisions, a high level of ethical sensitivity is critical. In this respect, it is suggested that continuing education after graduation and training programs should be organized.
- MakaleAçık Erişim2019Anticholinergic and antidiabetic effects of isoeugenol from clove (Eugenia caryophylata) oil
Topal, Fevzi
Isoeugenol (2-methoxy-4-(prop-1-en-1-yl)phenol), a component of from clove (Eugenia caryophylata) oil, is a starting material for both the biotechnological and synthetic production of vanillin and vanillic acid. In this article, the isoeugenol showed excellent inhibitory effects against some metabolic enzymes such as acetylcholinesterase (AChE) enzymes, α-glycosidase, and α-amylase. Isoeugenol has the IC50 values of 411.5 for α-amylase, 19.25 nM for α-glycosidase and 77.00 nM for AChE. Ki values of isoeugenol were found as 21 ± 9 nM and 16 ± 3 nM against α-glycosidase and AChE, respectively. On the other hand, tacrine as standard AChE inhibitor exhibited IC50 value of 20.38 nM. α-Glycosidase inhibitors, commonly referred to as starch blockers, are anti-diabetic drugs that help reduce edible blood glucose levels. AChE inhibitors are used for the treatment of some neurologic degenerational diseases, which involve Alzheimer’s disease. Also, there is a growing interest and the need to search for newer effective and safe AChE, α-amylase, and α-glycosidase inhibitors for the treatment of some metabolic disorder.
- MakaleAçık Erişim2019Investigation of certain nutritional properties of noodle enriched with raw flaxseed
Yuksel, F.
In this study, traditional homemade noodles were enriched with raw flaxseed and some nutritional properties such as resistant starch (RS), total starch, total dietary fibre (TDF), estimated glycaemic index (eGI) and major mineral composition of final products were investigated. Flaxseed was supplemented into the noodle mixture at three different concentrations (10, 15 and 20 g/100 g). RS content of the samples was in the range of 0.61-2.14 g/100 g and the highest RS was found for the sample having 10% flaxseed. Maximum TDF value was determined to be 8.28% for the noodle sample enriched with 20% of flaxseed while that of control was 1.68%. Estimated eGI of the samples was not significantly affected by the flaxseed fortification while mineral composition of noodle samples was significantly affected by the flaxseed addition (P < 0.05). The major mineral compounds present in the samples were sodium, potassium, magnesium and phosphorus. It could be concluded that the noodle enriched with 10% of flaxseed would be a healthier alternative product for consumption.
- MakaleAçık Erişim2019The inhibition profile of sesamol against α-glycosidase and acetylcholinesterase enzymes
Topal, Meryem
Sesamol (1,3-benzodioxol-5-ol) is found in the oilseed product, sesame. In our study, the inhibitory effects of sesamol compound on acetylcholinesterase and α-glycosidase enzymes were evaluated. Another aim of this study was to compare the inhibitory effects of sesamol to acarbose for α-glycosidase enzyme and tacrine for acetylcholinesterase (AChE). Sesamol exhibited non-competitive inhibition for both metabolic enzymes. IC50 values for AChE and α-glycosidase enzymes were calculated as 86.63 nM and 99.00 nM, respectively. On the other hand, Ki values were calculated as 46.68 nM and 75.33 nM for AChE and α-glycosidase enzymes, respectively. According to the obtained results showed effective inhibition at low concentrations.
- MakaleAçık Erişim2019The Impact of Education About Cervical Cancer and Human Papillomavirus on Women's Healthy Lifestyle Behaviors and Beliefs: Using the PRECEDE Educational Model
Koç, Zeliha; Özdeş, Emel Kurtoǧlu; Topatan, Serap; Çinarli, Tuǧba; Şener, Asuman; Danaci, Esra; Palazoǧlu, Cansu Atmaca
Background Early detection of cervical cancer improves the chances of successful treatment. Objective The aim of this study was to determine the effect of education about cervical cancer and human papillomavirus on the healthy lifestyle, behavior, and beliefs of Turkish women who were without cancer, using the PRECEDE education model. Methods This qualitative and quantitative study was conducted as a prospective, randomized, 2-group (intervention and control) trial at a community training center in north Turkey. A total of 156 Turkish women who were without cancer participated in this study. The semistructured interview form, the SF-36 Health Status Questionnaire, the Health Belief Model Scale for Cervical Cancer and Pap Smear Test, and the Healthy Lifestyle Behavior Scale II were used. Results The subdimension scores of the Health Belief Model Scale for Cervical Cancer and Pap Smear Test were found to be higher among women in the study group (cervical cancer seriousness, P =.001; health motivation, P =.001) as compared with the control group after the education program. The SF-36 Health Status Questionnaire domain scores for physical role limitations, mental role limitations, and general health perceptions increased in the study group after the intervention. Conclusion The posteducation health motivation of women in the study group was improved, the women's perceptions of obstacles to Papanicolaou testing decreased, and through increased knowledge and awareness, the rate of Papanicolaou testing increased. Implications for Practice Educational programs aimed at motivating women to increase their awareness of cervical cancer, preventing cervical cancer, and having Papanicolaou testing are necessary and beneficial in this sample.
- MakaleYalnız künye2019Dimethyl Sulfoxide Extract of Dianthus carmelitarum Induces S Phase Arrest and Apoptosis in Human Colon Cancer Cells
Turan, Ibrahim; Demir, Selim; Aliyazicioglu, Rezzan; Kilinc, Kagan; Ozer Yaman, Serap; Akbulut Cakiroglu, Kubra; Kanbolat, Seyda; Ayazoglu Demir, Elif; Mentese, Ahmet; Aliyazicioglu, Yuksel
Although several studies have investigated the cytotoxic effects of different Dianthus species, there has been only limited research into the cytotoxic effect of Dianthus carmelitarum. The purpose of this research was to evaluate the phenolic characterization and the cytotoxic effect of D. carmelitarum on human colon cancer (WiDr) cells and the possible mechanisms involved. Total polyphenolic contents (TPC) and phenolic characterization of the extract were evaluated using the Folin-Cioceltau method and reversed-phase high performance liquid chromatography (RP-HPLC), respectively. The cytotoxic activity of the extract was determined using the methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay. The mechanism involved in the extract’s cytotoxic effect was then evaluated in terms of apoptosis and the cell cycle using flow cytometry, while mitochondrial membrane potential (MMP) was investigated using the fluorometric method. The TPC value of the extract was 784.8 ± 40.3 mg gallic acid equivalent per 100 g sample, and sinapic acid and benzoic acid were detected as major phenolics in the extract. D. carmelitarum extract exhibited a selective cytotoxic effect (3.6-fold) on WiDr cells compared to normal colon cells. The extract induced cell cycle arrest at the S phase and apoptosis via reduced MMP in WiDr cells. Phytomedical and nutraceutical applications of D. carmelitarum may represent promising approaches in the treatment of cancer.
- MakaleYalnız künye2019Cancer risk analysis of some drinking water resources in Gümüşhane, Turkey
Karabıdak, Salih M.; Kaya, A.; Kaya, S.
Water; it is the basic necessity of living things that exist in the world like air and food. An adult person consumes an average of 2 L of water per day by drinking. This consumed water contains a number of radionuclides. For this reason, it is important to determine the effect of these radionuclides on human biological structure. In studies up to now, researchers calculate activity concentrations of radionuclides in drinking water and calculate annual equivalent doses based on these activity concentrations. However, it is always overlooked that this consumption is constant in calculations. This results in the inability of drinking water to fully determine the effect on human health. In this study, a new and comprehensive perspective was introduced in the gamma analysis of drinking water. This viewpoint includes the activity concentration, the annual equivalent dose, lifetime average annual dose, and lifetime cancer risk assessment depending on age groups. Thus, it is aimed that the radionuclides present in water can make more reliable calculations on affecting human health and water cleaning in terms of radiation. The proposed model was applied to some drinking water sources in Gümüşhane. We found out that the obtained values of annual effective dose equivalent in all samples do not exceed the WHO recommended levels. The risk of cumulative cancer at the end of the 70th year of a person using these drinking water sources has been about determined as 1 in 100,000. Positive correlations were obtained between 226Ra, 232Th, and 40K concentrations versus pH. In addition, a negative correlation was obtained 40K concentration with conductivity.
- MakaleAçık Erişim2019Employees’ opinions on critical success factors and performance criteria in disaster and emergency management
Sahinoz, Saime; Yaprak, Unal; Sahinoz, Turgut
Objective: To evaluate the critical success factors at disaster and emergency management and to analyse their impact on performance to guide the managers and decision makers. Methods: This was a cross-sectional study. It included all staff working in the fire brigade, 112 Emergency, Disaster and Emergency Management Authority and Red Crescent institutions serving in emergency situations in five provinces (Rize, Artvin, Trabzon, Gümüşhane, Bayburt) in the Eastern Black Sea region of Turkey. One province (Gümüşhane) was selected by cluster sampling method. Questionnaire which is the data collection method in the study was applied between 08/01/2016-02/02/2016 to all of the staff working in the fire brigade, 112 Emergency, Disaster and Emergency Management Authority and Red Crescent institutions serving in emergency situations in Gümüşhane province. Results: It has been found out that there is a significant and positive relationship between all of the critical success factors, planning, response and recovery criteria, and performance variance. Conclusions: The presence of well-planned emergency aid systems in the institutions or organizations involved in this area is an element of success. For this reason, this factor should be given more importance.
- MakaleAçık Erişim2019Centaurea hypoleuca DC: Phenolic content, antimicrobial, antioxidant and enzyme inhibitory activities
Özcan, Kadriye; Acet, Tuba; Çorbacı, Cengiz
Centaurea hypoleuca is one of the plants have been traditionally used in treatments of many diseases in folk medicine in Turkey. In the present study, ethanol, methanol, and ethyl acetate extracts of the plant's aerial parts were examined and their antioxidant, antimicrobial, and enzyme inhibition activities were determined for the first time. The antioxidant assays were performed in vitro using ABTS and DPPH methods, whereas the antimicrobial efficiency was determined using disc diffusion and microdilution methods. Moreover, the enzyme inhibition activity was analyzed using calorimetric methods targeting the key enzymes used in the treatment of Alzheimer's disease (cholinesterase) and diabetes (glucosidase and amylase). Also, the phenolic contents were analyzed using HPLC. The biological activity of flower ethyl acetate extract was found to be significantly higher than those of other extracts. This extract was more prominent because of its strong antimicrobial activity with the MIC value of 8 µg mL−1 against MRSA. Moreover, the main components of the extract were determined to be catechin and chlorogenic acid. In conclusion, these results indicate that C. hypoleuca can be pharmaceutically used as herbal remedies for its antioxidant, antimicrobial, and enzyme inhibitor effects.
- MakaleYalnız künye2019Examining the effect of “Shotblocker” in relieving pain associated with intramuscular injection
Aydin, Esra; Avşar, Gülçin
This study was conducted in order to examine the effect of “Shotblocker” in relieving pain associated with intramuscular injection. The population of the study consisted of all the patients who were hospitalized in the hospital and received intramuscular diclomec treatment. In order to eliminate the individual pain differences, each patient constituted their own control group. Patient Information Form, Visual Analogue Scale (VAS), and Shotblocker were used to collect the data. Pain level of the patients was measured by using VAS within the first minute after the injection. The pain mean score of the patients was 1.22 ± 0.62 in the experimental group and 2.48 ± 1.12 cm in the control group and the difference between them was statistically significant (p < 0.001). Shotblocker was determined to be effective on relieving pain associated with intramuscular injection.
- MakaleYalnız künye2019Effects of Kefir on Quality of Life and Sleep Disturbances in Postmenopausal Women
Özcan, Handan; Oskay, Ümran; Bodur, Ali Fuat
The aim of this study is to identify the effects of kefir, an alternative treatment method, on quality of life and sleep disturbances in postmenopausal women. In this study, it is seen that kefir has positive effects on sleep disturbances, depression, and quality of life in postmenopausal women.
- MakaleAçık Erişim2019Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma
Demirci, M.; Tokman, H.B.; Uysal, H.K.; Demiryas, S.; Karakullukcu, A.; Saribas, S.; Cokugras, H.; Kocazeybek, B.S.
Introduction and objectives: The amounts of Akkermansia muciniphila and Faecalibacterium prausnitzii in gut microbiota are reduced in patients with allergic diseases compared to healthy controls. We aimed to quantify levels of A. muciniphila and F. prausnitzii amounts using real-time quantitative PCR (qPCR) in the gut microbiota of children with allergic asthma and in healthy controls. Materials and methods: In total, 92 children between the ages of three and eight who were diagnosed with asthma and 88 healthy children were included in the study and bacterial DNA was isolated from the stool samples using the stool DNA isolation Kit. qPCR assays were studied with the microbial DNA qPCR Kit for A. muciniphila and microbial DNA qPCR Kit for F. prausnitzii. Results: Both bacterial species showed a reduction in the patient group compared to healthy controls. A. muciniphila and F. prausnitzii were found to be 5.45 ± 0.004, 6.74 ± 0.01 and 5.71 ± 0.002, 7.28 ± 0.009 in the stool samples of the asthma and healthy control groups, respectively. Conclusions: F. prausnitzii and A. muciniphila may have induced anti-inflammatory cytokine IL-10 and prevented the secretion of pro-inflammatory cytokines like IL-12. These findings suggest that A. muciniphila and F. prausnitzii may suppress inflammation through its secreted metabolites.
- MakaleAçık Erişim2019Is there prejudice against obese persons among health professionals? A sample of student nurses and registered nurses
Yılmaz, Hacı Ömer; Yabancı Ayhan, Nurcan
Purpose: The aim of this study was to assess whether there is prejudice toward obese persons among student nurses and registered nurses. Design and Method: A total of 379 participants were included (190 student nurses, 189 registered nurses). The Fat Phobia Scale and Belief About Obese Persons Scale were used to determine the prejudice. Findings: Registered nurses were found to have more negative prejudices toward obese persons than those of student nurses. These prejudices were determined to be influenced by the nurses' body mass index and having an obese person in the family. Practical Implications: Both groups had negative prejudices toward obese persons, there was a higher level of prejudice among the registered nurses. These prejudices can have a negative impact on healthcare practices.
- MakaleYalnız künye2019Inhibition profiles of Voriconazole against acetylcholinesterase, α-glycosidase, and human carbonic anhydrase I and II isoenzymes
Topal, Fevzi
In this work, the inhibitory activity of Voriconazole was measured against some metabolic enzymes, including human carbonic anhydrase (hCA) I and II isoenzymes, acetylcholinesterase (AChE), and α-glycosidase; the results were compared with standard compounds including acetazolamide, tacrine, and acarbose. Half maximal inhibition concentration (IC50) values were obtained from the enzyme activity (%)-[Voriconazole] graphs, whereas Ki values were calculated from the Lineweaver-Burk graphs. According to the results, the IC50 value of Voriconazole was 40.77 nM for α-glycosidase, while the mean inhibition constant (Ki) value was 17.47 ± 1.51 nM for α-glycosidase. The results make an important contribution to drug design and have pharmacological applications. In addition, the Voriconazole compound demonstrated excellent inhibitory effects against AChE and hCA isoforms I and II. Voriconazole had Ki values of 29.13 ± 3.57 nM against hCA I, 15.92 ± 1.90 nM against hCA II, and 10.50 ± 2.46 nM against AChE.
- MakaleAçık Erişim2019Determination of antibiotic resistance genes and virulence factors in Escherichia coli isolated from Turkish patients with urinary tract infection
Özad Düzgün, Azer; Okumuş, Funda; Saral, Ayşegül; Çopur Çiçek, Ayşegül; Cinemre, Sedanur
Introduction: Escherichia coli ranks among the most common sources of urinary tract infections (UTI). Methods: Between November 2015 and August 2016, 90 isolates of E. coli were isolated from patients at Rize Education and Research Hospital in Turkey. Antibiotic susceptibility was determined for all isolates using the Kirby-Bauer disk diffusion method. These E. coli isolates were also screened for virulence genes, β-lactamase coding genes, quinolone resistance genes, and class 1 integrons by PCR. Results: With respect to the antibiotic resistance profile, imipenem and meropenem were effective against 98% and 90% of isolates, respectively. A high percentage of the isolates showed resistance against β lactam/β lactamase inhibitor combinations, quinolones, and cephalosporins. PCR results revealed that 63% (57/90) of the strains carried class 1 integrons. In addition, a high predominance of extended-spectrum β-lactamases (ESBLs) was observed. The qnrA, qnrB, and qnrS genes were found in 24 (26.6%), 6 (6.6%), and 3 (3.3%), isolates, respectively. The most common virulence gene was fim (82.2%).The afa, hly, and cnf1 genes were detected in 16.6%, 16.6%, and 3.3% of isolates, respectively. Moreover, we observed eleven different virulence patterns in the 90 E. coli isolates. The most prevalent pattern was fim, while hly-fim, afa-aer-cnf-fim, aer-cnf, afa-aer, and afacnf- fim patterns were less common. Conclusions: Most of the E. coli virulence genes investigated in this study were observed in E. coli isolates from UTI patients. Virulence genes are very important for the establishment and maintenance of infection.
- MakaleAçık Erişim2019Prostate volume effect on Gleason score upgrading in active surveillance appropriate patients
Çamur, Emre; Coskun, Alper; Kavukoglu, Ovunc; Can, Utku; Kara, Onder; Çamur, Arzu Develi; Sarica, Kemal; Narter, Kamil Fehmi
Introduction: Gleason Score (GS) upgrading rates in the literature are reported to be around 33-45%. The relationship between prostate volume and GS upgrading should be defined, aiming to reduce upgrading rates in patients with low risk groups who are eligible for active surveillance (AS) or minimally invasive treatment, by varying biopsy cores, or lengths of cores according to prostate volumes. In this regard, the aim of our study was to establish the relationship between prostate volume and GS upgrading. Materials and methods: We retrospectively analyzed the medical records of 78 patients, who were appropriate for AS between 2011-2016 at our hospital. Inclusion criteria were patient age under 65 years, PSA level under 10 ng/ml, GS (3 + 3) or (3 + 4), and 3 or less positive cores, clinical stages <= T2. GS increase in radical prostatectomy specimen was considered as 'upgrading' and in addition, score reported by biopsy as 3 + 4 but in surgical specimen as 4 + 3 were also considered as 'upgrading'. The effect of prostate volume on Gleason grade upgrading was examined by calculating upgrading rates separately for patients with prostate volume 30 ml or less, those with 30 to 60 ml, and those over 60 ml. Results: As a result of the analysis of the data, upgrading was seen in 35 (44.8%) of 78 patients included in the study. In the cohort mean prostate volume was 49.8 (+/- 26.3) ml. Twenty-two patients (28.2%) had prostate volume 30 ml or less, 34 (43.6%) 30 to 60 ml, and 22 (28.2%) 60 ml or more. The patients were divided into two groups as those with and without GS upgrading. Between the groups prostate volume and prostate volume range (0-30/31-60/> 60) were not significantly different (p value > 0.05). Conclusions: Gleason grade upgrading causes patients to be classified in a lower risk group than they actually are, and may lead to inappropriate treatment. This condition has a direct effect on the decision of active surveillance. Therefore, it is important to define the factors that can predict GS upgrading in active surveillance appropriate patients. In this study, we found that prostate volume has no significant effect on upgrading in active surveillance appropriate patients.
- MakaleAçık Erişim2019Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS
Gulcin, Ilhami; Kaya, Ruya; Goren, Ahmet C.; Akincioglu, Hulya; Topal, Meryem; Bingol, Zeynebe; Cakmak, Kader Cetin; Sarikaya, Sevim B. Ozturk; Durmaz, Lokman; Alwasel, Saleh
Ethanolic (EEC) and aqueous (WEC) extracts of cinnamon (Cinnamomum verum) were evaluated for their antioxidant profiles by eight distinguished bioanalytical antioxidant methods. Their inhibitory effects were tested against some enzymes including acetylcholinesterase, butyrylcholinesterase, alpha-glycosidase and alpha-amylase, which linked to different diseases. Additionally, the antioxidant properties were determined and polyphenolic compositions of the both extracts were evaluated by LC-MS/MS analysis. According to the LC-MS/MS experiments, thirteen compounds were found in WEC and EEC. Also, p-hydroxybenzoic acid (321.1 mg/kg extract), p-coumaric acid (291.4 mg/kg extract), and pyrogallol (142.4 mg/kg extract) were found to be the most abundant ingredients in the WEC. On the other hand, pyrogallol (264.3 mg/kg extract), ferulic acid (224.7 mg/kg extract) and p-coumaric acid (170.2 mg/kg extract) were found as the most plentiful chemicals in the EEC. For the estimation of the antioxidant capacities of the both extracts (WEC and EEC), DPPH center dot and ABTS(center dot+) scavenging activities, as well as Fe3+-Fe2+, and Cu2+-Cu+ reducing assays were studied. The IC50 values of the WEC and EEC indicated that they were potent effective DPPH center dot (21. 25 and 15.71 mu g/mL) and ABTS(center dot+) (6.52 and 5.79 mu g/mL) scavengers, as well as AChE (221.33 and 110.26 mu g/mL), BChE (461.69 and 94.93 mu g/mL), alpha-glycosidase (206.86 and 220.00 mu g/mL) and alpha-amylase (189.86 and 200.86 mu g/mL) inhibitors. As a conclusion, both EEC and WEC had rich phenolic contents and demonstrated effective anticholinergic, antidiabetic and antioxidant effects.
- MakaleYalnız künye2019A novel niosome formulation for encapsulation of anthocyanins and modelling intestinal transport
Fidan-Yardimci, Melike; Akay, Seref; Sharifi, Fatemeh; Sevimli-Gur, Canan; Ongen, Gaye; Yesil-Celiktas, Ozlem
The bioavailability of drugs can be improved by regulating the structural properties, particularly lipoid systems, such as niosomes, can increase cellular uptake. Herein, we optimized double emulsion and niosomal formulations for encapsulating anthocyanin-rich black carrot extract. Nanoparticles obtained by selected formulation were characterized in terms of morphology, particle size, drug encapsulation efficiency, in vitro release and cytotoxicity. The optimum conditions for niosomal formulation were elicited as 30 mg of cholesterol, 150 mg of Tween 20 and feeding time of 1 min at a stirring rate of 900 rpm yielding the lowest average particle size of 130 nm. In vitro release data showed the majority of the encapsulated anthocyanins were released at the end of 10 h. A mathematical model was developed to estimate the absorption of anthocyanins released from niosomes and cytotoxicity was assessed against neuroblastoma. Overall, these findings suggest that niosomal vesicles might be suitable delivery systems for anthocyanins.
- MakaleYalnız künye2018İmalat Sanayisinde İş Sağlığı ve Güvenliği Üzerine Bir Araştırma: Erzincan İli Mobilya İşletmeleri Örneği
Komut, Osman; Yasar, Sekip Sadiye
Türkiye mobilya sektörü, ihracatı ithalatından yüksek olan az sayıdaki sektörden birisidir. Yıllık ihracat rakamı 2,2 milyar doları bulan sektörün AB pazar payında son dönemde daralma görülmektedir. Günümüzde global pazarlarda kullanılan önemli rekabet araçları arasına daha iyi kalite ve standartlarda iş güvenliği politikalarının uygulanması da eklenmiştir. İş sağlığı ve güvenliği düzenlemeleri, çalışanların iş kazası ve meslek hastalıklarından korunmasının yanı sıra ürün yaşam döngüsü ve çalışma koşullarının kalitesinin iyileştirilmesine de katkı sağlamaktadır. Bu çalışmada, mobilya üretim sektöründe çalışanların iş sağlığı ve güvenliği farkındalığı ile demografik faktörler ve işletme içi etkenlerin bu konuya ilişkin görüşlerine etkisinin tespit edilmesi amaçlanmıştır. Bu kapsamda, Erzincan ilinde bulunan 35 adet işyerinde toplam 84 çalışana yüz yüze görüşme esasına dayalı anket uygulaması yapılmıştır. Araştırma sonunda, mobilya üretim işletmelerinde iş kazasına maruz kalma oranının %61 olduğu ve bu çalışanların %50’sinin en az iki kez iş kazasına maruz kaldığı tespit edilmiştir. Diğer yandan, çalışanların yaşı, eğitim durumu, çalıştığı departman, çalışma süresi, iş değiştirme sıklığı ve makine-ekipman bakım sıklığı değişkenlerinin çalışanlar arasında istatistiksel anlamlı (p<0,05) görüş farklılıklarına neden olduğu anlaşılmıştır. Ayrıca, makine-ekipmandaki güvenlik donanımı yetersizliği, güvensiz davranışlar, iş sağlığı ve güvenliğine ilişkin eğitim yetersizliği, kişisel nedenler ve aşırı iş yükünün çalışanlar tarafından en önemli iş kazası nedeni olarak görüldüğü tespit edilmiştir.
- MakaleAçık Erişim2018Enhancement of bioavailable micronutrients and reduction of antinutrients in foods with some processes
Hendek, Muge; Bektaş, Müberra
The most of plant foods, nuts and cereals contain antinutrient compounds. They reduce to mineralbioavailability and protein absorption of foods thanks to their chelating properties. They causes tomicronutrient malnutrition and mineral deficiencies. The micronutrient malnutrition is a widespreadglobal health problem not only in developing but also in many countries. Increasing micronutrientintake in food through food processing based approaches is a sustainable method of prevention ofmicronutrient malnutrition which should be achieved through food diversification. There are traditionaland technological methods that provide reducing of antinutrient compounds.The pretreatmentand processing techniques as soaking, fermentation, germination, debranning, and autoclaving areeven traditional methods which use generally in consumption of foods.Removing antinutrients, thebioavailability of some cation (Ca, Fe and Zn) and the absorption of proteins make to increase andconsequently nutrition value of food increase. It is possible to reduce antinutrient factors by usingdomestic or industrial basic food processing techniques alone or in combination.This review focusedon various methods to reduce antinutrients in food such as phytic acid, tannin, and oxalate in foodgrain to improve nutritional quality of foods.
