SDG 3 · Sağlık ve Kaliteli Yaşam · SDG · Gümüşhane Üniversitesi

Yazarlar

Yayınlar

Yeniden eskiye Eskiden yeniye

MakaleYalnız künye2020Scopus SJRQ3/r/gumushane/16405
Potential therapeutic effects of ethyl pyruvate and N-acetyl cysteine in an experimental rat model of corrosive esophageal
Tatli, Ozgur; Pasli, Sinan; Imamoglu, Melih; Cicek, Mustafa; Yadigaroglu, Metin; Sahin, Aynur; Dilaver, Irem; Yulug, Esin; Karaca, Yunus
Background and study aims: Esophageal burns due to ingestion of corrosive substances are frequently seen in both children and adults. However, there is no standard method of treatment to prevent associated mortality and morbidity. Therefore, this study aimed to evaluate the effects of known antioxidants, namely N-acetyl cysteine and ethyl pyruvate, on esophageal damage due to sodium hydroxide-induced corrosive burns. Materials and methods: Thirty-five female rats were randomly assigned to five equal groups. Group 1 was the sham group, while Group 2 was the control group. Group 3 received N-acetyl cysteine, Group 4 received ethyl pyruvate, and Group 5 received both N-acetyl cysteine and ethyl pyruvate. Rats in the burn groups were gavage-fed with 0.2mL of 25% NaOH. All esophagi were extracted on day 4 for histopathological evaluation. Results: Total histopathological damage scores were evaluated at the end of the study. Groups 3 and 5 were significantly different from the control group in terms of total histopathological scores (p = 0.001), while no significant difference was seen with Group 4. Stenosis index results in groups 3 and 5 were similar to those seen with total histopathological scores (p = 0.004). Conclusion: N-acetyl cysteine, alone or in combination with ethyl pyruvate, may be useful in the treatment of esophageal damage associated with corrosive substances and in achieving histopathological improvement in an experimental setting. (C) 2020 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved.
AtıfWoS4OpenAlex3
İncele
MakaleAçık Erişim2020/r/gumushane/16306
The examination of Yo-Yo intermittent recovery test performance of young soccer players at different playing positions
Bayrakdaroglu, Serdar; Ari, Erdal; Özkamçi, Huseyin; Can, Ibrahim
Purpose: The aerobic fitness in soccer is an important performance component. The aerobic endurance level of players may positively effect performance of critical match activities. The examination of Yo-Yo intermittent recovery test (YYIRT) performance of young soccer players at different playing positions was aimed in this study. Material: The research group was consisted of 75 young soccer players playing at U-21 category of professional soccer teams at different leagues. The soccer players at 5 different playing positions participated in study voluntarily (centerback: n=15, fullback: midfielder: n=15, winger: n=15, forward: n=15). The YYIRT (level 1) was performed for determination aerobic endurance parameters (covered distance during test, maximum oxygen uptake (VO2max) and maximal aerobic speed (MAS) of players. The one-way ANOVA analysis was used for comparison between playing positions of YYIRT parameters. Results: It was determined that difference between YYIRT parameters of players at different playing positions was non-significant (p>0.05). However, the midfielders covered more distance (2425,33 +/- 440,42 m) than forward (2146,67 +/- 339,64 m), winger (2137,33 +/- 615,18 m), fullback (2056,00 +/- 512,43 m) and centerback (1960,00 +/- 313,51 m) players. The positional requirements of midfielders may be decisive on covered distance during YYIRT. Conclusions: Consequently, it may be said that the young soccer players at different playing positions had similar YYIRT performance and the playing position effect on YYIRT performance could vary depending on league level and individual features of players.
AtıfWoS1OpenAlex6
İncele
MakaleAçık Erişim2020/r/gumushane/16288
Bladder Sparing Surgical Treatment in a Patient with Pelvic Lipomatosis
Tarhan, Fatih; Kayukoglu, Ovunc; Can, Utku; Özgül, Aydin
Pelvic lipomatosis is an uncommon benign disease characterized by the excessive growth of mature fat tissue in the perivesical and perirectal areas. A 61-year-old male patient, who was admitted with voiding difficulty, underwent bladder-sparing surgery with excision of adipose tissue for pelvic lipomatosis. The case is presented and discussed with the relevant literature.
İncele
MakaleAçık Erişim2020/r/gumushane/16280
The Healing Effect of Resveratrol on Ischemic Tissue Injury in an Experimental Carbon Monoxide Poisoning Model
Sahin, Aynur; Pasli, Sinan; Cicek, Mustafa; Karahan, Suleyman Caner; Mentese, Ahmet; Yulug, Esin; Karaca, Yunus; Tatli, Ozgur
Purpose: To investigate the healing effect of resveratrol on ischemia, inflammation and oxidative injury in brain and heart tissue of rats in an experimentally induced carbonmonoxide (CO) intoxication model. Methods: Twenty-eight mature female Spraque Dawley rats were randomized into four groups of seven animals each. Groups I and II inhaled room air for 60 minutes. Groups III and IV inhaled a high concentration of a 5000 ppm CO gas mixture at 4 L/min until loss of consciousness. Blood CO levels were measured from 1 mL blood specimens collected from the tail vein. Groups I and III received 1 mL of normal saline while groups II and IV received 25 mg/kg resveratrol intraperitoneally. At the end of 48 hour, the rats were sacrified and later blood, brain and heart tissue samples were taken for histopathological and biochemical evaluation. Neuron damage scores, percentages of degenerate neurons and apoptosis rates in the cortex and hypothalamus were calculated in brain tissues. Myocyte degeneration, vascular congestion and myocyte apoptosis rates were calculated in heart tissues. Total antioxidant (TAS), total oxidant (TOS) and oxidative stress index (OSI) levels were also calculated from the tissue samples. Results: Histopathological evaluation revealed that resveratrol significantly reduced tissue damage in the brain when groups III and IV were compared (p<0.05). Resveratrol also reduced cardiac myocyte degeneration and myocyte apoptosis rate in heart tissue (p=0.004 and p=0.002). No positive effect was determined at analysis of antioxidant parameters. Conclusion: The results of this study investigated that resveratrol administration in experimental setting may be beneficial in healing injury secondary to CO intoxication in brain and heart tissue.
AtıfWoS2OpenAlex2
İncele
Derleme MakaleAçık Erişim2020/r/gumushane/16114
Vaccination Studies Against COVID-19 Agent: Current Status
Hintistan, Sevilay; Kazak, Aysun
The emergence of the new pathogenic viral strains is a constant threat to global health. The latest new coronavirus strain coronavirus-2019 (COVID-19) is the best-known example of this. COVID-19, caused by the severe acute respiratory syndrome-CoV-2 virus has quickly spread around the globe. The applications of drug and vaccine practices, and the identification of potential candidates are of high importance against this pandemic. On healthy adults, a proper evaluation of potential vaccines in parallel with vaccination studies on animal models and an enlargement of production capacity will benefit minimum risk and accelerated COVID-19 vaccine studies for human subjects. The purpose of this review is to contribute to the analysis of vaccine development strategies, vaccine development stages, phase studies and the difficulties, production stages and current status of potential vaccine studies developed to prevent COVID-19.
AtıfOpenAlex2
İncele
MakaleAçık Erişim2020/r/gumushane/16089
Knowing and Use Situations of Hemovigilance System in the Scope of Blood Transfusion Safety of Nurses: Rural Example
Demirag, Hatice; Hintistan, Sevilay
Objective: This study was carried out to determine the nurses' knowledge of the hemovigilance system and their use of it, within the scope of blood transfusion safety. Methods: The sample of this descriptive and cross-sectional study consisted of all nurses (n=65) working at Gumushane State Hospital. The data were collected with Structured Question Form Number, percentage, mean, Continuity Correction, Pearson Chi-Square and Fisher Exact tests were used to evaluate the data. Results: Of the nurses, 90.8% were women, the average age was 27.01 +/- 5.16 (20-48) years and 86.1% had undergraduate or higher education. Of the nurses, 84.6% knew that they were supervised by a hemovigilance nurse. Nurses (43.1%) who received training on the hemovigilance system had higher levels of knowing that each unit of blood taken from the donor follows the final destination (100.0%) than the nurses who did not receive training (p <0.05). The nurses who knew that they were supervised during transfusion related processes performed the following steps at a higher rate than those who did not know that they were inspected (p <0.05): Wearing gloves before the application (100.0%), using appropriate branches in children (87.3%), obtaining written consent before blood transfusion (100.0%), and completing the blood transfusion within a maximum of four hours (87.3%) were higher than nurses who did not know that they were supervised (p <0.05). Also; the majority of nurses (90.8%) were determined to use the current procedures for blood transfusions. Conclusion: In line with the findings of the study, it was stated that the nurses who were educated about the hemovigilance system and who knew that they were supervised by the hemovigilance nurse, had high hemovigilance system usage.
AtıfWoS2OpenAlex9TR Dizin2
İncele
MakaleYayıncıda açık erişim2020/r/gumushane/16029
Complementary and Alternative Medicine Methods Used for Sleep Disturbance in Menopause
Özcan, Handan; Çakmak, Suzan; Salman, Ebru
Objective: One of the most common complaints observed during the menopausal period is sleep disorders, affecting 40%-60% women. In this study, we aimed to determine complementary and clternative medicine (CAM) for menopausal women experiencing sleep disturbances, and the prevalence and influencing factors of sleep disturbance. Materials and Methods: In this descriptive cross-sectional study, we included menopausal women experiencing sleeplessness [>= 4 degree of discomfort according to the Visual Analog Scale (VAS)] (n=201). A questionnaire and the CAM Scale were used to collect data. The necessary institutional and ethical committee permissions were obtained. Results: The mean age of the menopausal women was 47.23 +/- 4.53 [minimum (min)- maximum (max), 30-60] years, and their mean VAS for insomnia was 5.20 +/- 1.12 (min-max, 4-9). The following methods were used by the women to overcome insomnia: herbal supplements (96.6%), dietary supplements (98.8%), religious practices (95.7%), and mind-body practices (76.9%). The most common methods were fruits and vegetables, milk and dairy products, honey, linden tea, rosehip, prayer, pray, and music. Approximately 70.5% women expressed that the method they used was effective. Conclusion: Almost all menopausal women used any method of CAM. Further studies on the effectiveness of these methods as well as the training to be provided and the information dissemination by healthcare professionals are recommended.
AtıfWoS7OpenAlex12TR Dizin4
İncele
MakaleAçık Erişim2020/r/gumushane/16025
Evaluation of Patients Infected with Human Immunodeficiency Virus Followed in Our Clinic
Kurt, Esma Kepenek; Kandemir, Bahar; Erayman, Ibrahim; Bulut, Rukiyye; Bitirgen, Mehmet
Introduction: The number of people infected with human immunodeficiency virus (HIV) in our country is increasing day by day. In this study, epidemiological, clinical, laboratory features, treatment regimens and side effects of HIV/AIDS cases followed in our clinic were evaluated. Materials and Methods: Fifty-four patients who were followed up with HIV infection in our clinic between 2000-2018 were examined retrospectively. Results: Of the 54 patients, 18 (33.3%) were females and 36 (66.7%) were males. Mean age was 42.0 +/- 15.2 (18-70) years. Mean duration of the disease was median 3 (0.5-28) and the duration of clinical follow-up was 3.3 +/- 2.7 (0.5-10) years. A total of 44 (88%) patients had risky sexual contact, and nine women were infected by her husband. The first complaint of the patients for admission to our clinic was weakness (22.2%) and fever (9.3%). Patients were diagnosed most frequently during routine examinations (48%). Mean CD4 count of the patients at the time of admission was 317.2 +/- 247.7 (7-918) cell/mm(3), and HIV-RNA was median 61000 (0-30000000) copy/mL. The most frequent treatment was tenofovir disoproxil fumarate-emtricitabine and lopinavir/ritonavir (TDF-FTC and LPV/r) in 24.4% of the patients. Treatment was changed in 14 (25.9%) patients. In five patients, noncompliance to treatment and in five patients, side effects were encountered, and treatment was changed. Hyperlipidemia was the most common side effect (52.9%) in patients receiving treatment. Prophylaxis was given to 50% of the patients in terms of opportunistic infections at the beginning of treatment. One patient had gonococcal urethritis and one patient had HPV infection in the cervix. Four patients discontinued treatment and 46 patients continued treatment. One female patient was exitus. Conclusion: The number of HIV/AIDS patients, a chronic disease, is increasing also in our country. Early diagnosis of these patients should be made, and the disease should be controlled by providing access to treatment and suppression of viral load.
AtıfWoS2OpenAlex2
İncele
MakaleAçık Erişim2020Scopus SJRQ3/r/gumushane/16017
The Effects of Boron (Orthoboric Acid) Supplementation into Diets on Serum Lipid and Protein Profiles of Hens During Late Laying Period
Kaya, Hacer; Macit, Muhlis
This study was carried out to determine the effects of boron addition into the diets on serum parameters of hens. A total of 288 Lohman laying commercial hybrid chickens of 62 weeks were fed for 12 weeks with four different rations containing basal feed 0 (B0), 50 (B50), 75 (B75) and 150 (B150) mg / kg B. Each group was replicated in 18 cages, four hens per cage. During the study, 16 hours lighting program was applied, feed and water were given as ad-libitum. The effect of boron supplementation was not significant on the rates of diacylglycerol and hydrocarbon+cholesterol esters (P>0.05) but the rates of polarlipid, triacylglycerol (P<0.05), and serum total cholesterol (P<0.01) were found significant. Lipid peroxidation values of groups fed with diets including 75 and 150 mg/kg B were determined lower than others. Addition of ration B affected different molecular weight proteins at different levels. In conclusion, it has been determined that the addition of B at different levels into the diets of laying hens during late laying period significantly influenced the serum lipid peroxidation, serum lipid and serum protein profile, but further researches are needed to clarify the changes related to the effects of B addition into diets on mentioned parameters of laying hens.
AtıfTR Dizin1
İncele
MakaleAçık Erişim2020/r/gumushane/15846
Lymphedema Information and Prevention Practices of Women After Breast Cancer Surgery
Aydin, Aydanur; Gürsoy, Ayla
AIM: This study was carried out to determine women's knowledge about lymphedema precautions and their practice status. The sample of this descriptive and correlationally designed study included 107 women who underwent surgery. METHOD: This descriptive study's data were collected using a questionnaire form developed by the researcher. The data were structured on a 3-point Likert-typescale.The one-way analysis of variance, correlations, and the Kolmogorov-Smirnov test were used in the statistical analysis. RESULTS: Three-quarters of the women knew that they should do arm exercises, keep the arm above the heart level while resting, and that blood pressure should not be measured, and jewelry not be worn. However, it was found that the percentage of women who did not know that the arm circumference should be measured at regular intervals or how to evaluate the arm circumference measurements and what to do in case of an injury was the same. It was determined that the precautions that the majority of women took in measuring lymphedema consisted of not measuring blood pressure, not wearing tight jewelry, and wearing an appropriate bra. CONCLUSION: It is thought that patients should be informed about the development of lymphedema after breast cancer surgery because their compliance with taking the precautions will be important in reducing the incidence, degree, and effects of lymphedema.
AtıfWoS7OpenAlex8
İncele
MakaleYalnız künye2020Scopus SJRQ2/r/gumushane/14974
Effect of Turkish Propolis on miRNA Expression, Cell Cycle, and Apoptosis in Human Breast Cancer (MCF-7) Cells
Misir, Sema; Aliyazicioglu, Yüksel; Demir, Selim; Turan, Ibrahim; Hepokur, Ceylan
Enriched in flavonoid compounds, phenol acids, and terpene derivatives, propolis has been shown to regulate apoptosis signaling pathways and alter the expression of microRNAs (miRNAs). In the present study, it has been aimed to examine the effects of Turkish propolis on miRNA levels of breast cancer (MCF-7) cells, and its relationship with cell proliferation and apoptosis. Cytotoxic activity of ethanolic propolis extract (EEP) was evaluated using MTT assay. Mechanisms involved in the cytotoxic action of Turkish propolis in MCF-7 cells were investigated with regard to apoptosis and cell cycle using flow cytometry and western blot. Mitochondrial membrane potential (MMP) were evaluated by spectrofluorometric method. miRNA levels were detected by qRT-PCR method. EEP exhibited selective toxicity against MCF-7 cells compared to normal fibroblast cells. EEP increased the cell cycle arrest at the G1 phase. EEP elevated the apoptotic cell death through increasing pro-apoptotic protein levels (p21, Bax, p53, p53-Ser46, and p53-Ser15), decreasing MMP and altering the expression levels of specific tumor suppressors (miR-34, miR-15a, and miR-16-5p) and oncogenic (miR-21) miRNAs. These data support that Turkish propolis may be evaluated as a potential natural agent for new anticancer drugs in future.
AtıfScopus42WoS43OpenAlex56
İncele
MakaleAçık Erişim2020/r/gumushane/14895
RP-HPLC-UV Analysis of the Phenolic Compounds, Antimicrobial Activity Against Multi-Drug Resistant Bacteria and Antioxidant Activity of Fruit and Seed of Diospyros lotus L.
Akar, Zeynep; Karakurt, Aylin; Okumus, Funda; Cinemre, Sedanur; Duzgun, Azer Ozad; Akar, Bulent; Can, Zehra
The object of the present study was to investigate the antioxidant, antimicrobial activity and phenolic compounds of fruit and seeds of Diospyros lotus L. The fruits consumed by humans as nutrients were harvested from the plants that grow naturally in the province of Trabzon-Akçaabat, Eastern Black Sea Region of Turkey. The antioxidant activities of fruit and seeds of Diospyros lotus were determined by using four methods (% DPPH radical scavenging activity, FRAP antioxidant power determination, CUPRAC reducing antioxidant activity and total phenolic content (TPC) in five different proportion of methanol-water extracts. All extracts of fruit and seeds of D. lotus analyzed through whole antioxidant analysis methods showed significant antioxidant activity. In addition, antimicrobial activity of fruit and seeds extracted with DMSO was determined against seven standard bacteria and three multi-drug resistance clinical strains. Although fruit extracts did not have the antimicrobial activity against bacteria, seeds showed antimicrobial effect to both standard strains (Gram-negative and Gram-positive) and antibiotic resistance clinical isolates (Klebsiella pneumoniae carrying blaKPC, Acinetobacter baumannii, harboring blaOXA-23 gene and resistance to colistin, and multi-drug resistant Pseudomonas aeruginosa). MICs’ value of plant seed extracts for standard strains was 0.75-25 mg/mL and antibiotic resistant clinical bacteria were 12.5 and 25 mg/mL. Additionally, phenolic compounds in methanol extracts of fruit and seeds were also determined in by HPLC using 19 standards. Gallic acid and chrysin phenolic compounds were the major phenolic compounds in fruit and seeds, respectively.
AtıfScopus8OpenAlex9TR Dizin3
İncele
MakaleAçık Erişim2020Scopus SJRQ3/r/gumushane/14871
Investigation of healthy living strategies in elderly who achieved to live long and healthy
Sahinoz, Turgut; Sahinoz, Saime
Objective: To determine the lifestyles, healthy living strategies and socio-cultural characteristics of elderly people who lived long and healthy. Methods: This study was a cross-sectional study. This study was conducted on 472 elderly patients, aged 80 years and over, selected by random sampling method. The socio-demographic characteristics and daily living activities of the elderly were determined by face to face interview technique using the “Elderly Questionnaire” developed by the researchers in 2018. Chi-square test was used for statistical analysis. Results: Based on the average age (84) of the elderly in the research group, it was seen that they were able to exceed the average life expectancy of their fathers (72) and mothers (73). It has been found that the participants live 11-12 years longer than their parents. It was also found that more than half (51.9%) of the elderly have the habit of walking regularly every day. It was determined that the elderly mostly consumed vegetables and fruits (88.5%), milk and dairy products and meat, respectively. Conclusion: The elderly stated that natural and healthy nutrition, working and staying away from stress in the top three places as the reason of their long and healthy life.
AtıfScopus6WoS5OpenAlex9
İncele
MakaleAçık Erişim2020Scopus SJRQ1/r/gumushane/14799
Effect of cellulose nanofiber-based coating with chitosan and trans-cinnamaldehyde on the microbiological safety and quality of cantaloupe rind and fresh-cut pulp. Part 1: Microbial safety
Zhang, Jin; Ozturk, Samet; Singh, Rakesh K.; Kong, Fanbin
This study aimed to evaluate the effect of cellulose nanofiber (CNF)-based coating containing chitosan (CHI) and trans-cinnamaldehyde (TC) on microbial growth of foodborne pathogens and spoilage microorganisms on cantaloupe rind and fresh-cut pulp. Coated/uncoated cantaloupe rind and pulp samples were inoculated with Salmonella enterica, Escherichia coli O157:H7 and Listeria monocytogenes and subsequently subjected to storage for 20 d at 4 °C or 12 d at 22 °C. Results showed that coating with only CNF (0.5%, dry-base) was effective in the elimination of S. enterica and E. coli O157:H7. Adding CHI (1%, w/w) and TC (1%, w/w) into CNF-based coating enhanced film formation on the surface and increased the antimicrobial activity on rind sample, but the reduction effect was less significant on pulp samples. The CNF (0.5%, dry-base) +CHI (1%, w/w) +TC (1%, w/w) coating resulted in 2.23, 2.43 and 3.22 log10 CFU/cm3 reduction of S. enterica, E. coli O157:H7 and L. monocytogenes, respectively, on pulp samples after 20 d at 4 °C. The formulation also significantly inhibited the growth of natural spoilage microorganisms, and no growth was observed up to 18 d at 4 °C. Results indicated that CNF-based coating significantly improved microbial safety of cantaloupe rind and fresh-cut pulp during storage by forming a physical barrier reducing activities of oxygen-dependent microorganisms.
AtıfScopus13WoS9OpenAlex10
İncele
MakaleAçık Erişim2020Scopus SJRQ3/r/gumushane/14792
Illness perception, perceived social support and quality of life in patients with diagnosis of cancer
Aydın Sayılan, Aylin; Demir Doğan, Melike
Introduction: Research has shown that social support has a significant impact on quality of life. The purpose of this cross-sectional study was to determine the relationship between perceived social support, perception of disease and quality of life, and the factors affecting these, in patients with cancer in Turkey. Methods: The study data were collected from two hospitals. Data were collected using the face-to-face interview method from patients diagnosed with cancer between March and August 2018. No sampling was performed, and the entire population was studied. Results: The mean age of the patients in the study was 61.37 ± 14.89 years. Married patients had better social support than single individuals (t = 2.129; p = 0.035). Significant negative correlation was found between the illness perception scale and total quality of life scale score (r = −0.163; p = 0.026), and physical well-being (r = −0.224; p = 0.002) and social well-being (r = −0.199; p = 0.006) subscales. Conclusion: Patients’ social support and quality of life were at moderate levels. Married participants had better social support than single participants, and operated participants had better social support than unoperated participants. As illness perception decreased, quality of life, physical well-being and social well-being increased.
AtıfScopus51WoS42OpenAlex43
İncele
MakaleAçık Erişim2020Scopus SJRQ3/r/gumushane/14786
The impact of dietary tarragon (Artemisia dracunculus) on serum apelin, brain-derived neurotrophic factor, cardiac troponin concentrations and histopathology of liver tissue in laying hens housed at different stocking densities
Bayraktar, Bulent; Tekce, Emre; Kaya, Hacer; Karaalp, Musa; Turunc, Eylul
Due to its association with several other stress factors (poultry house gases, inadequate ventilation, heat, cold and poor hygiene), the high stocking density is a major stress factor that adversely affects the health and performance of poultry and the quality of the poultry products. Therefore, this experimental study was aimed at analysing the impact of different doses of dietary tarragon (Artemisia dracunculus) on the serum apelin, plasma brain-derived neurotrophic factor (p-BDNF), and cardiac troponin I (cTnI) concentrations, and the correlation between these indicators in laying hens housed at different stocking densities. The aim of this study is to investigate the effects of adding tarragon in different ratios to laying hen rations in the 2ndovulation period on the cTnI, apelin, and BDNF hormone concentrations and the liver histopathology. The experiment was carried out over a period of eight weeks, with 192 Lohman Brown commercial hybrids at 50 weeks of age. Eight groups (four replicates each), composed of laying hens of equal body weight, which were housed at stocking densities of 580 cm2/hen and 810 cm2/hen and received 0, 1, 5 and 10 mmol/kg of tarragon (Artemisia dracunculus) in the feed, were established. At the end of the trial, 96 of the housed egg-laying hens (3 birds in each subgroup, a total of 12 birds in each group) were randomly selected and blood samples were taken from the vena subcutanea ulnaris. The samples collected were analysed for the apelin, p-BDNF, and cTnI contents. The analysis results demonstrated that tarragon supplementation had no effect on the serum apelin, p-BDNF and cTnI concentrations (P > 0.05). The Sub-Groups ST1, ST1.2, and ST6 presented with severe hyperaemia of the sinusoidal, portal and acinar blood vessels, whilst the hyperaemia of these blood vessels was moderate in Sub-Group ST12. Apelin, BDNF, and cTnI can act as protective factors against negative consequences of stress (e.g., stocking density or heat stress).
AtıfScopus5WoS7OpenAlex2
İncele
MakaleAçık Erişim2020Scopus SJRQ2/r/gumushane/14688
The Costs of Disability in Turkey
İpek, Egemen
In this study, the additional economic cost of disability for households is calculated using a standard of living approach (SoL) for Turkey. Firstly, the Standard of Living (SoL) index is determined using principal components analysis through the Household Budget Survey data for the year 2014. The cost of disability is estimated using ordered logit method by dividing the index into three income groups such as low, middle and high. As a result of the analysis, it is estimated that households with disabilities need additional financial support of at least 9.1% of household income in order to reach the same standard of living as those without disabled individuals. In addition, two different levels of disability, which are working life disability and daily life disability, are considered in estimating the cost of disability. While the cost caused by individuals’ disabilities in working life is 14.6% of their household's income, the ratio is 9.1% for the individuals’ disabilities in daily life.
AtıfScopus16WoS12OpenAlex19
İncele
MakaleAçık Erişim2020Scopus SJRQ2/r/gumushane/14670
Biological activities and phytochemical screening of ethanol extracts from adonis paryadrica (Ranunculaceae)
Ucuncu, Osman; Baltaci, Cemalettin; Akar, Zeynep; Duzgun, Azer Ozad; Cuce, Mustafa; Kandemir, Ali
In this study, secondary metabolite profiles of flower, leaf and root of Adonis paryadrica ethanolic extracts were performed by using a newly developed and validated LC-MS/MS method. For this purpose, the LC-MS/MS system was used for the quantitative and qualitative analysis of 37 phytochemicals. The main component of the flower, leaf and root extracts was the quinic acid (160, 111 and 64 mg/kg, respectively). Antioxidant activities were determined using methods such as DPPH (SC50, mg/mL), FRAP (µM TEAC), CUPRAC (µM TEAC), ABTS (SC50, mg/mL) and TPC (GAE, µg/mL). While the highest antioxidant activity value for FRAP, CUPRAC, ABTS and TPC methods was determined in the leaf part of the plant, this value was determined in the flower part for DPPH. The antibacterial effects of the plant extracts were determined by liquid microdilution and agar diffusion methods. As a result, antimicrobial effect of flowers, leaf and all sections of plant extracts were determined except plant root extracts which did not display any activity against bacteria. Antimicrobial activity of the plant flower extract was found to be higher especially against to P. vulgaris with 3.5 mg/mL MIC.
AtıfScopus11WoS8OpenAlex17
İncele
MakaleYalnız künye2020Scopus SJRQ2/r/gumushane/14666
Phytochemical profile and biological activity of a therapeutic orchid from Anatolia: Dactylorhiza romana subsp. georgica
Kotiloğlu, Deniz; Acet, Tuba; Özcan, Kadriye
In Anatolia, the tubers of Dactylorhiza romana subsp. georgica orchid are consumed as food and frequently used in folk medicine to alleviate the symptoms of some disorders. However, these properties have not been scientifically studied until the present day. In this research, we aimed to identify phenolic profile of the orchid tubers and determine their several features and functions. Among these, there are the antioxidant and antimicrobial effects and the inhibitory effect against diabetes related enzymes (α-amylase and α-glucosidase). In this sense, total phenolic content (Folin–Cicalteu assay), total antioxidant capacity (Phosphomolybdate method), antioxidant (ABTS and DPPH assays) and enzyme inhibition effects of tuber extracts obtained with different solvents (chloroform, ethyl acetate, methanol, ethanol, or hexane) were determined by using spectrophotometric methods, and the phenolic profile was also analysed by HPLC. In addition, antimicrobial activity of the extracts against 3 g (+) and 3 g (−) bacteria and 2 forms of yeasts was determined by disc diffusion and micro dilution methods. Based on our findings, the total phenolic content and antioxidant properties of ethyl acetate extract were considerably higher than the others. The most abundant among the screened phenolic standards was found to be benzoic acid. The highest α-amylase and α-glucosidase enzyme inhibition was measured in methanol and chloroform extracts, respectively. The highest antibacterial (B. cereus) and anticandidal (C. tropicalis and C. albicans) activities were detected in the chloroform and ethyl acetate extracts, respectively. In short, it was clearly seen that the D. romana subsp. georgica tuber had a great potential for being used in food and drug industries as a source of bioactive compounds.
AtıfScopus16WoS10OpenAlex16
İncele
MakaleAçık Erişim2020Scopus SJRQ4/r/gumushane/14619
The mediating role of self-compassion in the relationship between perceived COVID-19 threat and death anxiety; [Algılanan COVID-19 tehdidi ve ölüm kaygısı arasındaki ilişkide öz şefkatin aracı rolü]
Kavaklı, Mehmet; Ak, Mehmet; Uğuz, Faruk; Türkmen, Osman Oğulcan
Objective: The COVID-19 pandemic is a new and highly detrimental event that has influenced the world over. Besides the obvious health risks, COVID-19 has also affected people psychologically. The high risk of contamination can increase the perceived COVID-19 threat and death anxiety in individuals. The aim of the present study was to investigate the mediating role of self-compassion in the relationship between perceived COVID-19 threat and death anxiety. Additionally, the study also investigated the role of gender, profession and income level in the perceived COVID-19 threat and death anxiety. Method: The research sample was composed of 562 individuals from the community. The data was gathered by using personal information form and the Perceived COVID-19 Threat Form, Self-Compassion Scale and Turkish Death Anxiety Scale. Results: The relationship between perceived COVID-19 threat and death anxiety was partially mediated by self-compassion. Moreover, people in the high income group had a lower level of perceived COVID-19 threat and death anxiety score compared to the low-income group. Perceived COVID-19 threat levels were lower among health care professionals compared to unemployed individuals. Female participants had a higher level of perceived COVID-19 threat and death anxiety score compared to male participants. Discussion: Self-compassion may be an essential variable to help cope with problems related to perceived COVID-19 threat and death anxiety. Improving our understanding of the psychological impacts of COVID-19 is necessary and essential.
AtıfScopus57WoS56OpenAlex41TR Dizin23
İncele