Gümüşhane ÜniversitesiGümüşhane ÜniversitesiAçık Erişim Arşivi · RDL Open

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  • MakaleAçık Erişim2026
    Ethical Principles and Frameworks in Dementia Care: A Scoping Review

    Serrat, Rodrigo; Lauridsen, Sigurd; Bobrowicz-Campos, Elzbieta; Brandao, Tania; Brites, Rute; Cannella, Valentina; Celdrán, Montserrat; Chacur-Kiss, Karima; Cin, Aynur; Fabà, Josep

    Providing ethical care for people living with dementia is essential for safeguarding their rights, dignity, and well-being. However, ethical decision-making in dementia care is complex, often involving tensions between competing moral claims such as autonomy, beneficence, nonmaleficence, justice, and non-discrimination. This scoping review aimed to map and describe the ethical principles, related normative considerations, and ethical frameworks discussed in the scientific literature on dementia care, and to identify how these have been conceptualized. Following the methodological guidance of Arksey and O'Malley (2005), Levac et al. (2010), and Peters et al. (2021, 2022), a comprehensive search across five databases (Web of Science, Scopus, CINAHL, Medline/PubMed, and PsycInfo) identified peer-reviewed papers published in English. In total, 388 papers published between 1981 and 2024 were included. The results revealed a wide range of ethical principles and related normative considerations frequently cited in the literature, although they were typically discussed in an isolated way without reference to other principles or broader ethical frameworks. In contrast, ethical frameworks were mentioned far less often, and when they were, they mostly reflected traditional approaches such as principlism. Four gaps were identified: the plurality of ethical frameworks and limited conceptual integration underpinning dementia care research and practice; insufficient attention to ethnic and socioeconomic diversity among people living with dementia; limited consideration of diverse care settings and geographical regions; and the limited inclusion of people living with dementia themselves in the studies reviewed. These findings underscore the need for conceptually integrative, inclusive, and context-sensitive approaches to dementia care ethics that can better inform both ethical reflection and care practices.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • DüzeltmeAçık Erişim2026
    Ethical Principles and Frameworks in Dementia Care: A Scoping Review (vol 19, 29, 2026)

    Serrat, Rodrigo; Lauridsen, Sigurd; Bobrowicz-Campos, Elzbieta; Brandao, Tania; Brites, Rute; Cannella, Valentina; Celdrán, Montserrat; Chacur-Kiss, Karima; Cin, Aynur; Faba, Josep

    Unfortunately, this article was published online with errors—the blinded names were not replaced. The corrected sentence is shown below. FROM: Step 2: Identifying Relevant Studies With the support of BLINDED FOR REVIEW, a professional librarian at the University of BLINDED FOR REVIEW, we developed and refined our search strategy through an iterative process involving the selection of both keywords and databases. TO: Step 2: Identifying Relevant Studies With the support of Joan Pons-Vila, a professional librarian at the University of Barcelona, we developed and refined our search strategy through an iterative process involving the selection of both keywords and databases.

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  • MakaleAçık Erişim2026
    Comparative study of magnetic and electric quadrupole moments in boron (5B) isotopes

    Ali, Ahmed H.; Tfiha, Amir D.; Zakaly, Hesham M. H.; Jarallah, Naz T.; Issa, Shams A. M.; Abdulqader, Abdulqader S.; Çelik, Necati; Bhuyan, M.

    The magnetic moments and electric quadrupole moments of the B-5 isotopes were calculated using different nuclear interactions and sets of effective charges. Instead of relying on core polarization, the effective charges were adopted through a microscopic theoretical approach. The one-body density matrix (OBDM) elements for these isotopes were calculated using the NuShellX@MSU code. The calculations were carried out within the shell model framework, using both the p- and psd-model spaces (MS). These model spaces were selected for nuclei with proton number Z = 5 and neutron number N > 3. The theoretical results for magnetic and quadrupole moments were compared with available experimental data. Theoretical magnetic moments of the B-8,B-10,B-11,B-12,B-13 isotopes showed good agreement with experiment when using the p-MS with the pwt interaction, and the psd-MS with the psdmwk interaction. Similarly, the theoretical electric quadrupole moments reasonably well with the experimental values when using the p-MS with the pkuo interaction, and the psd-MS with the psdmwk interaction.

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  • MakaleAçık Erişim2026
    Inspiratory muscle training enhances jumping power and shooting performance in elite air pistol athletes

    Aydin, Ahmet Serhat; Yilmaz, Coskun; Söyler, Mehmet; Güney, Gamze; Eyüboglu, Ender; Karakulak, Izzet; Ceylan, Tulay; Altug, Tolga; Burac, Daniela Giconda; Sahinler, Yunus

    Background Inspiratory muscle training (IMT) has been shown to enhance respiratory efficiency, postural stabilization, and neuromuscular coordination in athletic populations. However, its effects in precision sports such as air pistol shooting remain insufficiently explored. This study investigated the impact of a 4-week IMT program on respiratory muscle strength, explosive lower-limb performance, reaction time, and shooting accuracy in competitive air pistol athletes. Methods Twenty trained male air pistol athletes (age 18-35 years) were randomly assigned to an IMT group (n = 10) or a control group (n = 10). The IMT group performed supervised inspiratory muscle training twice daily (30 breaths/session), six days per week, for four weeks, using a threshold-loading device set initially at 40% of maximal inspiratory pressure (MIP), with progressive overload applied weekly. Both groups maintained their regular shooting training routines. Pre- and post-intervention assessments included countermovement jump (CMJ) and squat jump (SJ) performance (OptoJump), visual and auditory reaction time (Cognitech), and shooting performance evaluated via the SCATT system. A two-way repeated-measures ANOVA (group & times; time) was used for statistical analysis. Results Significant group & times; time interactions were observed for CMJ height (p < 0.001, eta & sup2;p = 0.618), CMJ power (p = 0.007, eta & sup2;p = 0.345), SJ height (p = 0.050, eta & sup2;p = 0.184), and SJ power (p = 0.050, eta & sup2;p = 0.181), indicating meaningful improvements in explosive performance in the IMT group. Shooting accuracy demonstrated a large and statistically significant interaction effect (p < 0.001, eta & sup2;p = 0.532), with substantial improvement observed only in the IMT group. Reaction time variables showed favourable but non-significant trends (p > 0.05). Conclusion A short-term IMT intervention significantly enhanced lower-limb explosive performance and shooting accuracy in competitive air pistol athletes without altering overall training load. These findings suggest that IMT may represent an effective, low-cost adjunct strategy to improve neuromuscular stability and fine-motor precision in precision-sport athletes.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2026
    A multi-evidence computational and experimental strategy for Silene nerimaniae: combining phytochemical characterization, bioactivity assessment, and ADEFRank-HCT-116-based metabolite prioritization

    Erharman, Ahmet; Yagi, Sakina; Uba, Abdullahi Ibrahim; Nikolic, Filip; Gasic, Uros; Acar, Mikail; Dogan, Nurettin; Koyuncu, Ismail; Yapici, Ismail; Gulcin, Ilhami

    This study presents the first comprehensive evaluation of the phytochemical composition, antioxidant properties, enzyme inhibitory effects, and cytotoxic potential of Silene nerimaniae G.E.Gen & ccedil;, Kandemir & & Idot;.Gen & ccedil; (family Caryophyllaceae). Ethyl acetate, acetone, 70% acetone, and aqueous extracts were obtained from the aerial parts of the plant through maceration. Among the tested extracts, the acetone extract contained the highest total phenolic (24.37 mg GAE per g) and flavonoid (24.64 mg RE per g) contents. LC-MS analysis identified 52 bioactive constituents, including sugars, organic acids, phenolic acids, flavonoids, and fatty acids. The aqueous extract demonstrated the strongest radical scavenging activity against DPPH (23.02 mg TE per g) and ABTS (55.76 mg TE per g), as well as the highest Fe3+ reducing power (37.53 mg TE per g). In combination with the acetone extract, it also exhibited notable Cu2+ reducing activity (47.78 mg TE per g). Regarding enzyme inhibition, the ethyl acetate, acetone, and hydroacetone extracts displayed the strongest inhibitory activities against acetylcholinesterase (1.87 mg GALA per g), butyrylcholinesterase (2.92 mg GALA per g), and tyrosinase (60.44 mg KAE per g), respectively. All three extracts also inhibited alpha-amylase activity within the range of 0.73-0.77 mmol ACAE per g (p >= 0.05). In addition, the hydroacetone extract showed considerable inhibition of human carbonic anhydrase isoenzymes I (IC50 = 38.78 mu g mL-1) and II (IC50 = 19.59 mu g mL-1). The ethyl acetate extract exhibited the strongest cytotoxic effect against the colorectal cancer cell line HCT-116, with an IC50 value of 0.639 mu g mL-1 and a selectivity index of 1.7. To contextualize this HCT-116-associated activity at the metabolite level, an ADEFRank-HCT116 (abundance-domain-evidence fusion ranking) workflow was applied by integrating EtOAc abundance, HCT-116-oriented QSAR evidence, applicability-domain confidence, and structure-assignment reliability. This analysis prioritized diosmetin, luteolin, eriodyctiol, acacetin, and isorhamnetin as core candidates for structure-based follow-up. Molecular docking screening predicted favorable docking profiles for the prioritized candidates, while 100 ns molecular dynamics simulations were used to assess the dynamic stability of the representative luteolin-PI3K alpha, diosmetin-AKT1, and isorhamnetin-GSK-3 beta complexes. Taken together, these results indicate that S. nerimaniae may represent a valuable source of active compounds for various functional nutraceutical, cosmetic and pharmaceutical uses.

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  • MakaleAçık Erişim2026
    Comparison of plyometric repeated sprint and plyometric aerobic training on physical performance in youth soccer players

    Selmi, Mohamed Amin; Hammami, Raouf; Ceylan, Halil Ibrahim; Duncan, Michael; Sassi, Radhouane Haj; Morgans, Ryland; Bayrakdaroglu, Serdar; Bragazzi, Nicola Luigi

    High-intensity interval training (HIIT) and repeated-sprint sets (RSS) are established conditioning methods in soccer, yet their integration with plyometric training among highly trained youth soccer players remains underexplored. This study investigated the effects of an 8-week program combining plyometric training with either RSS (PLYO-RSS) or HIIT (PLYO-HIIT) on physical fitness in young soccer players. Twenty-nine male players (14-15 years) were randomly assigned to PLYO-RSS (n = 14) or PLYO-HIIT (n = 15). Both interventions lasted 20 minutes per session and replaced part of regular soccer training. Physical fitness assessments included countermovement jump (CMJ), 15-s repeated vertical jumps (15''RJ), five-jump test (5JT), 10 m and 30 m sprint, maximal aerobic speed (MAS), VO2max, and repeated sprint performance (total sprint time, best sprint, fatigue index). Physiological markers (lactate, rating of perceived exertion, and HRmax) were also monitored. Significant improvements over time were observed in muscle power, sprint speed, aerobic capacity, and repeated-sprint ability (p <= 0.001; eta & sup2;p = 0.339-0.489). However, no main effects or group & times; time interaction effects were observed, indicating no evidence of differential responses between the two training modes. In conclusion, integrating plyometric training with either RSS or HIIT effectively enhances physical fitness in highly trained youth soccer players, offering flexible options for training prescription.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2026
    Chemical profiling, biological evaluation, and QSAR-informed metabolite prioritization of Hypericum ekerii: a first report on antioxidant, enzyme inhibitory, and cytotoxic activities

    Zengin, Gokhan; Yagi, Sakina; Cetiz, Mehmet Veysi; Uba, Abdullahi Ibrahim; Nikolic, Filip; Gasic, Uros; Balos, Mehmet Maruf; Erharman, Ahmet; Dogan, Nurettin; Koyuncu, Ismail

    Hypericum ekerii Y & uuml;ce and Ayta & ccedil;, first described in 2017, remains poorly characterized in terms of its phytochemical composition and biological properties. This study investigated aerial-part extracts of H. ekerii prepared with ethyl acetate, acetone, 70% acetone-water, and water. The hydroacetone extract showed the highest total phenolic and flavonoid contents. LC/MS analysis enabled the annotation of 99 constituents, including phenolic acids, flavonoids, xanthones, anthraquinones, and acylphloroglucinols. The hydroacetone extract exhibited the strongest radical-scavenging and reducing activities, whereas acetone and ethyl acetate extracts showed the highest metal-chelating capacity. In enzyme assays, hydroacetone was the most active extract against acetylcholinesterase, tyrosinase, and hCA II, while ethyl acetate showed greater inhibition of butyrylcholinesterase and hCA I. The aqueous extract was the most active against alpha-glucosidase, and hydroacetone and ethyl acetate showed comparable alpha-amylase inhibition. Cytotoxicity remained limited overall; the lowest IC50 value was observed for the ethyl acetate extract against HCT-116 cells (95.09 & micro;g mL-1), with weak selectivity (SI = 1.2). A QSAR-informed prioritization framework identified myricetin as the leading cross-layer candidate, p-coumaric acid as a target-specific priority metabolite, and ellagic acid, quercetin, and caffeic acid as antioxidant-priority candidates. Molecular docking supported favorable binding profiles for selected metabolites, while molecular dynamics simulations were used to assess the stability of representative complexes. Overall, H. ekerii appears to be a chemically diverse species with notable antioxidant and enzyme-inhibitory potential, providing a focused basis for future compound-level validation.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleYalnız künye2026
    Geochemical signature, detrital zircon U-Pb, and mica Ar-Ar age systematics from the Karadere Basement Unit of the İstanbul-Zonguldak Terrane (NW, Türkiye): evidence for an Avalonian-Cadomian active continental margin

    Çimen, Okay; Gücer, Mehmet Ali; Göncüoglu, Mehmet Cemal; Akal, Cuneyt; Arslan, Mehmet; Simonetti, Antonio; Karaoglan, Fatih

    The & Idot;stanbul-Zonguldak Terrane is located in northwest Anatolia and includes several outcrops with pre-Cambrian basement units. The Karadere Basement Unit represents the easternmost basement of this terrane and is composed of paragneiss, quartzite, and orthogneiss. The paragneiss and quartzite are cut by orthogneisses and disconformably overlain by Lower Ordovician to Middle Devonian cover units. Its pre-Cambrian to Palaeozoic tectonic evolution remains poorly understood, and therefore, this study reports whole-rock trace element signatures, detrital zircon U-Pb, and muscovite Ar-Ar age data for samples of paragneiss, quartzite, amphibolite, and orthogneiss. The whole-rock geochemical data indicate that the protoliths of the paragneiss and quartzite samples investigated here could have been derived from arc-related felsic magmatic units located in an active continental margin. The protoliths of amphibolites and orthogneiss samples are gabbro and granite, respectively, and their geochemical signatures are akin to those from continental arc igneous suites. The detrital zircon U-Pb data are characterized by predominantly Mesoproterozoic (84%) and lesser amount of Palaeoproterozoic and Neoproterozoic ages and suggest an early Tonian (youngest peak age of 915 +/- 18 Ma) maximum depositional age. Moreover, zircon U-Pb dating analyses from an orthogneiss sample yielded an age of 603 +/- 2 Ma, indicating the occurrence of mid-Ediacaran arc magmatism. This represents one of the oldest Ediacaran ages obtained from the metamagmatic basement rocks of the & Idot;stanbul-Zonguldak Terrane. Ar-Ar dating of muscovite from ortho- and paragneiss samples yielded ages of 533 +/- 25 Ma and 530 +/- 9 Ma, respectively, which are interpreted as early Cambrian cooling ages. Overall, the combined results reported here reveal that the Karadere Basement Unit is markedly different from NE African basement units but displays similarities to the basement rocks of both Avalonian and Amazonian terranes. It may have been formed and metamorphosed in an Avalonian-Cadomian active continental margin during the mid- to late Neoproterozoic and early Cambrian.

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  • MakaleAçık Erişim2026
    Long-term decline of Chernobyl-derived 137Cs in mosses and lichens from the Eastern Black Sea region of Türkiye

    Çevik, Ugur; Çelik, Necati; Uzun, Kubra K.; Çelik, Ahmet; Koz, Bahadir; Özen, Songul A.; Yesilkanat, Cafer M.; Hacisalihoglu, Aylin; Özkalayci, Fatih; Kaya, Selim

    This study presents the third consecutive assessment of 13 Cs activity concentrations in the same 50 moss (7 species) and lichen (2 species) sampling points in Ordu province, T & uuml;rkiye, one of the most heavily contaminated areas following the Chernobyl accident. Samples were collected from exactly the same locations used in the 1997 and 2007 studies and analyzed by high-resolution gamma spectrometry. In 2025, detectable 13 Cs was found in 14 of 30 moss sites (47%) and 3 of 20 lichen sites (15%). For samples below the minimum detectable activity (MDA), a value of MDA/2 (0.93 Bq kg-1) was substituted for lichens, while moss samples below the MDA were excluded from regression. The ecological half-life (Teco) for the 2007-2025 period was 4.38 +/- 1.05 years for mosses and 4.18 +/- 0.61 years for lichens. For mosses, this is nearly identical to the 1997-2007 mean (4.4 years), while for lichens it decreased from 5.6 to 4.18 years, suggesting a slight acceleration in environmental removal. All Teco values remain far shorter than the physical half-life of 13 Cs (30 years), confirming that environmental removal processes dominate over radioactive decay. Residual 13 Cs is concentrated in higher-altitude areas, reflecting the original deposition pattern and slower removal in cooler, more humid microenvironments. Nearly 39 years after the accident, the radiological risk posed by residual trace levels is negligible. This 28-year dataset provides one of the longest continuous records of 13 Cs in epiphytic bioindicators and serves as a valuable baseline for future contamination events.

    • SDG 15 · Karasal Yaşam
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  • MakaleAçık Erişim2026
    Mono- and Bis-Ureido Sulfapyridines as Nanomolar Dual Cholinesterase Inhibitors: Enzyme Kinetics, Molecular Docking, and ADME/Tox Insights

    Yapar, Gonul; Akocak, Suleyman; Lolak, Nebih; Topal, Meryem; Türkes, Cuneyt; Topal, Fevzi; Durgun, Mustafa; Koçyigit, Umit Muhammet; Isik, Mesut; Beydemir, Sukru

    A series of mono- and bis-ureido sulfapyridine derivatives (SP-1-SP-10) were synthesized and evaluated as dual cholinesterase inhibitors targeting acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). All compounds exhibited nanomolar inhibition. The most potent AChE inhibitors were SP-8 (K-i = 5.25 +/- 0.73 nM), SP-9 (5.09 +/- 0.44 nM), and SP-10 (5.74 +/- 0.55 nM), significantly outperforming tacrine (K-i = 105.03 +/- 8.85 nM) under identical conditions. For BChE, SP-9 showed the strongest inhibition (K-i = 26.38 +/- 2.07 nM) compared with tacrine (172.03 +/- 32.42 nM). Kinetic analyses revealed competitive inhibition toward AChE for all derivatives, whereas BChE inhibition displayed both competitive and noncompetitive patterns depending on structural features. Glide XP docking using AChE (PDB: 7XN1) and BChE (PDB: 4BDS), complemented by MM-GBSA binding free energy calculations, supported favorable ligand accommodation within the catalytic pockets and highlighted the importance of aromatic and hydrophobic interactions. In silico ADME/Tox analysis revealed a potency-drug-likeness trade-off: mono-ureido derivatives complied with Lipinski's rule of five and showed high predicted oral absorption, whereas bis-ureido derivatives, despite superior enzymatic potency, exhibited multiple drug-likeness violations. These findings identify the ureido-sulfapyridine scaffold as a potent enzymatic dual cholinesterase inhibitory framework, warranting further structural optimization to improve pharmacokinetic properties.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2026
    YOLOv8 computer vision for automated offside detection in professional football validated through supervised learning

    Abdel-Fattah, Abdul-Rahman; Belhaouari, Samir Brahim; Ceylan, Halil Ibrahim; Bayrakdaroglu, Serdar; Muntean, Raul Ioan; Dhahbi, Wissem; Dergaa, Ismail; Omri, Abdelfatteh El

    Offside calls are integral to maintaining fairness and competitive integrity in football, yet current officiating processes are constrained by limitations in accuracy despite technological advancements. This investigation developed and validated an automated offside detection system using YOLOv8 object detection architecture to address documented limitations of Video Assistant Referee (VAR) systems in offside decision accuracy. Supervised learning validation employed 400 annotated instances from professional match footage. The YOLOv8 medium variant was configured for four-class detection, with a focus on extreme player positions, reducing computational complexity by approximately 70% relative to comprehensive player tracking while accepting accuracy trade-offs in marginal scenarios. The system was optimized for computational efficiency through highly accurate tracking of player positions. Data were partitioned into 40% (n = 160) for training and 60% (n = 240) for testing, with 5-fold cross-validation. The automated system achieved robust performance metrics across 240 test instances: overall accuracy of 83.0%, precision of 85.0%, recall of 87.0%, and F1-score of 86.0%. Confusion matrix analysis revealed true positives (n = 130), true negatives (n = 70), false positives (n = 22), and false negatives (n = 18). Individual case analysis demonstrated 80% agreement with ground truth classifications. System performance significantly exceeded the random classification baseline (p < 0.001). The strategic extreme player tracking approach achieved substantial computational efficiency while maintaining decision accuracy across diverse match scenarios. A YOLOv8-based offside detection system demonstrates proof-of-concept feasibility for decision-support applications in football officiating. Performance (83% accuracy, 95% CI: 79-87%) on 240 test instances remains below professional benchmarks (> 93%), with single-camera constraints and limited dataset size restricting generalizability to proof-of-concept validation rather than operational deployment.

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  • MakaleAçık Erişim2026
    Short-Term Inspiratory Muscle Training Enhances Functional and Metabolic Health in Older Adults

    Konca, Erkan; Yilmaz, Coskun; Bayrakdaroglu, Serdar; Ceylan, Halil Ibrahim; Arslan, Ayla; Ocak, Hakan; Karakulak, Izzet; Sari, Rifat; Uzun, Recep Nur; Soylu, Hakan Huseyin

    Background: Age-related declines in respiratory muscle strength and ventilatory efficiency can impair functional capacity and metabolic health in older adults. Inspiratory muscle training (IMT) has been proposed as a practical intervention to counteract these changes, yet its systemic effects remain unclear. This study aimed to examine the effects of short-term IMT on functional capacity, diaphragm thickness, and liver tissue characteristics in healthy elderly men. Methods: Thirty community-dwelling men aged 60-80 years were randomly assigned to an IMT or control group. The IMT group performed four weeks of breathing exercises using a POWERbreathe (R) device at 40% of maximal inspiratory pressure, with a weekly 10% increase in pressure. Pre- and post-intervention assessments included the six-minute walk test (6MWT), diaphragm thickness and liver density via computed tomography, and quality of life (QoL; SF-12). Results: Four weeks of inspiratory muscle training significantly improved diaphragm thickness (11.7%), fatty liver density (FLD) (+16.7%), and six-minute walk performance (+5.3%), with large time x group effects favoring the IMT group. While the physical quality of life showed modest, comparable improvements, mental health outcomes demonstrated a moderate, time-dependent improvement without a significant group-by-time interaction. Conclusions: Short-term IMT improved diaphragmatic function and functional capacity in older men and was associated with favorable changes in a liver-related biomarker; however, given that only a single liver-related metric was assessed, these findings should not be interpreted as evidence of overall improvements in liver health.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleYayıncıda açık erişim2026
    The mediating role of mental fatigue awareness in the relationship between perceived stress and psychological well-being among combat athletes

    Yilmaz, Taner; Öz, Faik; Gül, Oguzhan; Dal, Suzan; Kara, Tayfun; Akkoç, Orkun; Küçük, Hamza; Fort, Patricia Roxana; Çitozi, Robert; Kadi, Mustafa Nurullah

    Background Combat athletes face unique psychological demands, and stress may influence both their cognitive experiences and psychological well-being. This study aimed to examine the mediating role of mental fatigue awareness in the relationship between perceived stress and psychological well-being among combat athletes, thereby contributing to a clearer understanding of a potential cognitive mechanism linking stress to well-being in this population.Methods A total of 303 combat athletes voluntarily participated. Participants completed the Perceived Stress Scale, Mental Fatigue Awareness Scale, and Psychological Well-being Scale. Statistical analyses assessed the direct effects of perceived stress on psychological well-being, the effect of stress on mental fatigue awareness, and the potential mediating role of mental fatigue awareness.Results Perceived stress significantly increased mental fatigue awareness (b = 0.732, SE = 0.064, beta = 0.549, p = 0.001) and directly decreased psychological well-being (b = - 0.488, SE = 0.166, beta = - 0.191, p = 0.004). Mental fatigue awareness negatively affected psychological well-being (b = - 0.374, SE = 0.124, beta = - 0.195, p = 0.003) and partially mediated the relationship between stress and well-being (indirect effect: b = - 0.274, SE = 0.115, beta = - 0.107, p = 0.003; 95% CI = - 0.504 to - 0.049).Conclusion Perceived stress was associated with psychological well-being both directly and indirectly through increased mental fatigue awareness. These findings suggest that mental fatigue awareness may represent a relevant cognitive pathway linking stress perceptions to well-being. Accordingly, stress management and strategies aimed at regulating mental fatigue may be considered as potentially beneficial components in efforts to support psychological well-being among combat athletes.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleYalnız künye2026
    Chemical characterization and bioactivity assessment of Erodium cedrorum subsp. salmoneum extracts supported by in silico analysis

    Yagi, Sakina; Zengin, Gokhan; Zoltan, Cziaky; Jeko, Josef; Ivashchanka, Yahor; Turecka, Katarzyna; Halasa, Rafal; Gucwa, Magdalena; Kochan-Jamrozy, Kinga; Stefanowicz-Hajduk, Justyna

    The growing interest in natural products, particularly as food additives and pharmaceutical raw materials, is making research into discovering new sources especially important. Erodium cedrorum subsp. salmoneum (family Geraniaceae) is used traditionally to cure many ailments like diabetes and gastro-intestinal diseases. Within this background, the current study was designed to investigate, for the first time, the chemical composition, antioxidant and enzyme inhibitory poroperties of different extracts from the aerial parts and roots of E. cedrorum. Results revealed that the aqueous extract of the aerial parts accumulated the highest total phenolic (85.35 mg GAE/g) and flavonoids (28.65 mg RE/g) contents. A total of 61 and 45 compounds, belonging mainly to phenolic acids and flavonoids, were tentatively identified in the aerial parts and roots extracts respectively. The aqueous extract from the aerial parts exerted the highest antiradical, ions reducing and chelation properties. The EtOH and 70% EtOH extracts of the two organs recorded the best anti-acetylcholinesterase activity (2.18 -2.41 mg GALAE/g; p >= 0.05) while those of the roots recorded respectively the best anti-butyrylcholinesterase and antityrosinase activities. The most potent antibacterial activity was exhibited by the 70% EtOH extracts from aerial parts and the pure EtOH extracts from roots. In contrast, ethyl acetate extracts from both plant parts showed only marginal activity. Among the tested strains, the highest susceptibility was observed against C. sporogenes ATCC 19404, C. bifermentans ATCC 638, S. aureus ATCC 6538, S. aureus ATCC 43300 (MRSA), C. diphtheriae PCM 506, and H. pylori ATCC 43504. The extracts were also examined for their anti-cancer potential on the HeLa, AGS and SKOV-3 cell lines, as well as a non-cancerous cell line. The ethyl acetate extract of the roots exhibited the most potent anti-cancer activity, with the lowest IC50 values. In addition, selected top-ranked complexes against AChE, alpha-amylase, representative bacterial and oncogenic targets were further evaluated by molecular docking and 100 ns molecular dynamics (MD) simulations, indicating overall conformational stability and persistent binding. In conclusion, these results position E. cedrorum as a valuable natural source of antioxidant and enzyme-inhibitory agents, meriting further exploration for drug development purposes.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2026
    Effects of wrestling training on psychological well-being, anxiety, and resilience in adolescent boys

    Özkan, Ridvan; Yilmaz, Coskun; Uzun, Recep Nur; Bayrakdaroglu, Serdar; Akar, Ozge Orhan; Öz, Faik; Çiçekli, Atif; Çiçekli, Aylin; Dal, Suzan; Ursu, Vasile Emil

    Background Wrestling is a physically and mentally demanding combat sport that requires discipline, focus, and emotional control. Although its physiological effects are well documented, its psychological benefits in adolescents remain underexplored. This study aimed to examine whether a short-term, non-competitive wrestling program could enhance psychological well-being, reduce sport anxiety, and strengthen resilience in adolescent boys. Methods Thirty sedentary male adolescents (aged 12-15 years) were randomly assigned to a wrestling training group (n = 15) or a control group (n = 15). The intervention consisted of six weeks of supervised wrestling sessions performed three times per week. Psychological well-being (WHO-5), sport anxiety (SAS-2), and resilience (BPRS) were assessed before and after the intervention using the validated Turkish versions of the scales. Two-way repeated-measures ANOVA was used to analyze group & times; time interactions. Results Participants in the wrestling group demonstrated significant improvements in well-being (p < 0.001) and resilience (p < 0.001), alongside marked reductions in total sport anxiety and its subdimensions (p < 0.001), compared with the control group. All effects were large (eta p & sup2; = 0.52-0.94). Conclusion A structured six-week wrestling program produced meaningful psychological benefits in adolescent boys. Regular participation in non-competitive wrestling may serve as an effective approach to promote well-being, emotional stability, and adaptive coping skills during early adolescence, supporting the preventive and developmental role of combat sports in youth mental health.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleYalnız künye2026
    Building Resilience in Global Tourism: A Theoretical and Empirical Analysis of Indicators for Sustainable Development

    Erol, Ismail; Dogru, Tarik; Oztel, Ahmet; Bilgihan, Anil; Peker, Iskender; Neuhofer, Irem Onder

    The primary perspective of this study is the global tourism industry (GTI) as an interconnected supply chain network, encompassing both tourism firms (e.g., hotels, airlines, and operators) and destinations (e.g., local communities and ecosystems). This industry-level focus allows for analyzing resilience indicators that bridge firm-specific capabilities with destination-wide vulnerabilities, rather than isolating one over the other. Using a mixed-method approach, this research conceptualizes resilience through various management theories. First, it identifies critical resilience indicators across institutional, societal, economic, and ecological dimensions. Second, these indicators are analyzed with a novel Spherical Fuzzy Interpretive Structural Modeling and Cross-Impact Matrix Multiplication Applied to Classification framework, utilizing expert opinions to uncover complex interdependencies among indicators. The findings of this study highlight that effective government policies, robust incentive mechanisms, advanced digital infrastructure, dynamic capabilities, and ecologically sustainable tourism practices are key drivers of resilience. However, socioeconomic impacts, tourist satisfaction, and price competitiveness emerge as highly dependent outcomes influenced by these drivers. This study also introduces the Adaptive Global-Local Interaction Theory, a new framework that integrates global influences with local realities to enhance tourism resilience. By offering a comprehensive framework and practical guidelines, this research equips policymakers and stakeholders with actionable strategies to bolster the industry's capacity to anticipate, adapt to, and recover from crises, promoting sustainable development amidst volatile global conditions.

    • SDG 8 · İnsana Yakışır İş ve Ekonomik Büyüme
    • SDG 9 · Sanayi, Yenilikçilik ve Altyapı
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  • MakaleYalnız künye2026
    Comparison of automated subcortical segmentation methods: VolBrain vs. 3D Slicer in brain volumetry

    Acer, Niyazi; Palanci, Ozgur; Ipekten, Funda; Erdogan, Furkan Mert; Yarar, Burhan; Ozyasar, Ali Faruk

    Objective:Accurate volume measurements of subcortical brain structures are essential in neuroimaging studies. This study aimed to compare two automated segmentation algorithms, 3D Slicer and VolBrain, for subcortical brain volumetry. Method:Subcortical volume measurements obtained using 3D Slicer and VolBrain were compared using the Neurofeedback Skull-stripped (NFBS) dataset. Statistical analyses included the coefficient of determination (R2) and Bland-Altman (B-A) plots. Volumetric measurements from both tools were evaluated across multiple subcortical brain regions. Results:Strong agreement was observed for the caudate nucleus, thalamus, and hippocampus, while notable discrepancies were identified in the amygdala, globus pallidus, and nucleus accumbens. Both constant and proportional systematic errors were detected in certain regions, with greater variability observed in 3D Slicer measurements. Intraclass Correlation Coefficient (ICC) analysis demonstrated weak agreement for the accumbens and amygdala, and moderate agreement for the hippocampus and thalamus, highlighting region-specific differences in performance Conclusion:Both VolBrain and 3D Slicer are effective tools for subcortical brain volumetry. VolBrain provides a fully automated workflow, whereas 3D Slicer allows greater flexibility through detailed corrections. Method selection should be guided by research objectives, regions of interest, and image quality. Further validation across diverse datasets is warranted to improve clinical applicability, particularly in regions showing lower agreement.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2026
    Modeling Long-Term Postseismic Deformation Following the 2020 Mw 7.0 Samos Earthquake Using Campaign and Continuous GNSS Observations

    Solak, Halil Ibrahim; Tiryakioglu, Ibrahim; Gezgin, Cemil; Aladogan, Kayhan; Yalvaç, Sefa; Aktug, Bahadir; Yigit, Cemal Ozer; Dönmez, Ergin; Demirelli, Ertugrul; Eyübagil, Eda Esma

    Highlights What are the main findings? What are the implications of the main findings?Highlights What are the main findings? What are the implications of the main findings?Abstract Postseismic deformation provides fundamental insights into earthquake-cycle processes, lithospheric rheology, and stress redistribution following large earthquakes. Although the 2020 Mw 7.0 Samos earthquake has been extensively investigated in terms of coseismic deformation and early postseismic behavior, the long-term evolution of deformation following the event remains poorly constrained. This study characterizes the long-term spatiotemporal evolution of postseismic deformation associated with the 2020 Mw 7.0 Samos earthquake using combined campaign and continuous GNSS observations. A total of 18 GNSS stations were analyzed over an approximately 4.5-year period following the earthquake. Pre-earthquake GNSS velocities were incorporated as prior constraints, while postseismic deformation was modeled using linear, logarithmic, exponential, and combined logarithmic-exponential functions. The preferred model for each station component was identified using the corrected Akaike Information Criterion (AICc), and model-selection robustness was evaluated through 1000 Monte Carlo observation-perturbation simulations. The results reveal a spatially heterogeneous postseismic deformation field with station-dependent temporal behavior. Among the nonlinear solutions passing the Monte Carlo and goodness-of-fit criteria, the seven single-process LOG and EXP solutions yielded characteristic relaxation times ranging from 182.6 to 730.5 days, with a median of 438.3 days. The two LOGEXP solutions additionally contained a logarithmic timescale of 109.6 days and exponential timescales of 292.2-438.3 days. These findings demonstrate that campaign GNSS observations, when integrated with continuous GNSS data and an objective statistical framework, can provide meaningful constraints on the long-term evolution of postseismic deformation despite sparse temporal sampling. More broadly, the results emphasize the strongly time-dependent nature of postseismic deformation and the critical role of observation timing in capturing its spatiotemporal evolution.

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  • MakaleYalnız künye2026
    Petrogenetic constraints and phase equilibria modelling on amphibole-bearing high-grade metamafic rocks from the Maku ophiolite (NW Iran): implications for metamorphism along the central Neo-Tethyan suture

    Modjarrad, Monir; Uysal, Ibrahim; Yara, Irfan O. M. A.; Sen, Ahmet Dundar; Xin, Guangyao; Müller, Dirk

    We present an integrated petrological, mineral-chemical, whole-rock geochemical, microstructural, and phase-equilibrium study of the West Maku metamafics (WMM), an ophiolite-related mafic unit in NW Iran. The WMM comprises garnet amphibolites and amphibole-bearing high-grade metamafic rocks containing almandine-rich garnet, tschermakite-ferro-tschermakite, andesine, epidote/zoisite, annite, muscovite-phengite, spinel, ilmenite, chlorite, quartz, and K-feldspar. Immobile element systematics indicate a tholeiitic, MORB-like basaltic protolith; LILE and crust-sensitive element enrichment likely reflect inherited crustal/sediment-derived components and metamorphic redistribution during subduction-accretion and/or m & eacute;lange assembly. P-T modelling defines four relative stages: M1, upper greenschist-facies metamorphism at ca. 6.4 kbar and 360 degrees C; M2, prograde heating to 8.0-8.4 kbar and 700-720 degrees C; M3, peak upper-amphibolite- to granulite-facies conditions at 9.0-9.8 kbar and up to 810 degrees C, with localized anatexis; and M4, retrogression at ca. 3.8 kbar and 520 degrees C. The clockwise path records the burial and heating of MORB-derived crust in a subduction-accretionary setting, followed by collision-related thermal relaxation/crustal thickening and subsequent uplift. Regional comparisons indicate thermally heterogeneous evolution along the central Neo-Tethyan suture across Armenia, SE T & uuml;rkiye, NE Iraq and NW Iran.

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  • MakaleAçık Erişim2026
    Designing an industrial-scale radio frequency decontamination process for peanut butter

    Coskun, Eda; Ozturk, Samet; Tasci, Caner; Kahraman, Kubra; Liu, Shuxiang; Li, Rui; Wang, Shaojin; Mert, Behic; Marra, Francesco; Erdogdu, Ferruh

    Centers for Disease Control and Prevention (CDC) has reported outbreaks of Salmonella, particularly associated with low-moisture foods including peanut butter. Even though roasting is included along the processing line, the presence of these safety issues indicates the requirement of process following the packaging of the samples. Because of the lower thermal diffusivity of the peanut butter, a conventional thermal process is expected to be challenging with expected temperature non-uniformities. Therefore, radio frequency (RF) heating was considered in this study for thermal processing of peanut butter samples. For this purpose, a computational model was developed to determine the temperature change of peanut butter samples. Experimental studies for model validation were completed in a 10 kW - 27.12 MHz RF system at 3300 and 4000 V electrode potentials. Following the model validation, a comparison to the conventional thermal processing was presented, and industrial scale thermal processing studies were applied where up to 30 packaged samples were placed within the RF cavity. Process efficiency was determined with the process time decrease, temperature uniformity and decontamination effects. Science4Impact: This study demonstrated RF processing for an efficient thermal decontamination with uniform temperature distribution attained within the samples in an industrial scale process.

    • SDG 2 · Açlığa Son
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