Gümüşhane ÜniversitesiGümüşhane ÜniversitesiAçık Erişim Arşivi · RDL Open

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  • MakaleYalnız künye2026
    Nurses’ Experiences in Preventing or Reducing Sensory Deprivation and Sensory Overload in Intensive Care Patients: A Phenomenological Study

    Uzun, Sevda; Aslan, Çimen

    This study aimed to assess nurses’ experiences in preventing or reducing sensory deprivation and sensory overload in intensive care unit (ICU) patients, utilizing a phenomenological approach. The qualitative research involved face-to-face, semi-structured, in-depth interviews with 15 nurses working in a general ICU in the southern region of our country. Data collection continued until data saturation was achieved, and all interviews were audio recorded and transcribed. Colaizzi’s phenomenological analysis method was employed for data analysis, and adherence to the COREQ checklist was ensured throughout the study. The data analysis revealed 2 main categories (reflection on situations that may cause sensory deprivation and sensory overload in intensive care units and practices and coping experiences of nurses to avoid sensory deprivation and overload) and 6 themes (environment, disease, and its effects, being separated from the family environment and loved ones, challenges encountered, coping, and psychosocial applications). The results indicated that patients undergo sensory deprivation or sensory overload in the intensive care environment, with nurses playing a pivotal role in addressing these situations. It was observed that nurses encountered challenges in coping with sensory deprivation or sensory overload issues in patients. Nurses are advised to regularly assess training programs to ensure the ongoing promotion of safe nursing practices aimed at minimizing sensory deprivation or sensory overload in patients.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleAçık Erişim2026
    Whole-genome characterization of clinical Enterococcus faecalis and Staphylococcus epidermidis Isolates reveals mecA-positive E. faecalis and a shared lnu(A)–rep7a resistance plasmid in Türkiye

    Ejder, Nebahat; Özad Düzgün, Azer

    Background: This study aimed to genomically characterize clinical Enterococcus faecalis and Staphylococcus epidermidis isolates obtained from aspirate and sputum samples at Bayburt State Hospital, focusing on antimicrobial resistance genes, virulence factors, and mobile genetic elements. Methods: Whole-genome sequencing (WGS) was performed on the isolates, and antimicrobial resistance genes, virulence determinants, multilocus sequence types (MLST), plasmid replicons, and mobile genetic elements were identified using bioinformatics tools. Results: The E. faecalis E5 (ST64) isolate, recovered from an aspirate sample, carried multiple antimicrobial resistance genes, including mecA, vanT, erm(B), tet(M), and qacA, along with a diverse virulence gene repertoire (cyl, ebp, ace, and agg), mobile genetic elements (Tn6009, ISL1a3), and four plasmid replicons (rep19C, rep9C, repUS43, and rep7a). The E. faecalis E184 and E187 isolates (ST124), obtained from sputum samples, harbored fewer acquired resistance genes but shared gyrA (T672A) and parC (V307I) mutations associated with fluoroquinolone resistance. The S. epidermidis ST59 isolate carried resistance genes lnu(A), fosB, and qacD, together with the plasmid replicon rep7a and insertion sequence ISSau4. The co-occurrence of lnu(A) and the rep7a plasmid in both species suggests a potential pathway for interspecies transmission of resistance determinants. Conclusions: This study reports the genomic detection of mecA in an E. faecalis isolate from Türkiye based on WGS analysis. However, this finding is based solely on genomic data and lacks phenotypic or experimental validation. The detection of a shared plasmid-associated resistance element (lnu(A)–rep7a) in both E. faecalis and S. epidermidis highlights the potential for interspecies resistance gene flow within the hospital environment.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleYalnız künye2026
    A dynamic predictive model for Bacillus cereus growth from spores under temperature abuse conditions

    Juneja, Vijay K.; Osoria, Marangeli; Gao, Juan; Kapoor, Harsimran Kaur; Ozturk, Samet; Purohit, Anuj; Mishra, Abhinav

    Bacillus cereus, a common foodborne pathogen, can cause emetic and diarrheal food poisoning. The associated outbreaks are commonly caused by temperature abuse during food cooling, storage, and transportation. This study developed a model to predict B. cereus growth from spores based on isothermal growth data collected at 10–54.4 °C in tryptic soy broth. A four-strain spore cocktail was heated at 80 °C for 10 min and inoculated at an initial level of ∼2 log CFU/mL. Growth curves at temperatures showing growth (15–50 °C) were fitted using the Baranyi model. The average h0 value was 3.04. The temperature dependence of the maximum specific growth rate was characterized using the modified Ratkowsky model. The estimated theoretical minimum and maximum growth temperatures were 8.94 °C and 54.11 °C, respectively. The lag phase duration was related to temperature using a hyperbolic function. All models showed good agreement with the observed data, with satisfactory fit statistics (R2 = 0.953–0.998 and RMSE = 0.073–0.904). The Baranyi differential equations were solved numerically using a fourth-order Runge–Kutta method to build the dynamic model. Model validation was conducted under two sinusoidal non-isothermal temperature profiles (10–30 °C for 30 h and 25–45 °C for 23 h). The accuracy factor (Af) and bias factor (Bf) values were 1.2117 and 1.2117 for the 10–30 °C profile, and 1.1359 and 1.1288 for the 25–45 °C profile, respectively. These results demonstrated that the dynamic model could precisely predict B. cereus growth and be used as a baseline reference for food system research and risk assessment.

    • SDG 2 · Açlığa Son
    İncele
  • MakaleYalnız künye2026
    Emergency Nurses’ Experiences of Digital Silence: A Qualitative Study

    Bal, Betül; Kulakaç, Nurşen

    This study aimed to explore emergency department nurses’ perceptions and experiences of digital silence. A qualitative study was conducted with 14 emergency department nurses from two public hospitals in Turkey. Data were collected through semistructured in-person interviews and analyzed using the Framework Method for qualitative data analysis. Four overarching themes were identified: (i) awareness of digital silence, (ii) types of digital silence, (iii) causes of digital silence, and (iv) strategies for prevention. Digital silence manifests in several forms, including failure or partial completion of data entry, the use of alternative communication channels in place of official digital systems, and disregard for system alarms or alerts. The reasons underlying digital silence stem from both individual factors and organizational factors. Strategies to reduce digital silence involved training, development of user-friendly systems, establishment of nonpunitive reporting environments, and workload management. The results revealed that digital silence extends beyond individual attitudes, representing a multidimensional phenomenon closely associated with institutional structures, organizational culture, and the design features of digital systems. Enhancing system usability, reinforcing technical infrastructure, and promoting digital literacy were identified as key strategies for reducing digital silence behaviors.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleYalnız künye2026
    Integrating Artificial Intelligence Into Nursing Care Planning: A Comparative Evaluation of Psychosocial Care for Patients With a Stoma

    Kulakaç, Nurşen; Tuncer, Metin

    This methodological study evaluated and compared the content quality and appropriateness of nursing care plans developed by nurses and artificial intelligence (AI) for addressing the psychosocial problems of patients with stomas. Two nursing care plans addressing the psychosocial needs of a patient with a stoma were developed: 1 generated by nurses and 1 generated by an AI system. The content quality and appropriateness of the care plans were independently evaluated by 12 experts, including nursing academics and clinical nurses, using the DISCERN measurement tool. Inter-rater reliability was assessed using the intraclass correlation coefficient (ICC). The mean DISCERN score of the nurse-generated care plan was significantly higher than that of the AI-generated care plan (P=.008). Inter-rater agreement demonstrated good agreement. The findings indicate that nurse-generated care plans demonstrate superior content quality and overall integrity compared to AI-generated plans. AI-generated care plans exhibit potential as supportive tools in nursing care planning.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleYayıncıda açık erişim2026
    The Effect of Music-Repeating Robotic Parrot Therapy and Different Instrumental Live Music Therapies on Anxiety and Fatigue Levels in Hemodialysis Patients: A Randomized Controlled Trial

    Demirağ, Hatice; Cin, Aynur; Aktepe Coşar, Dilan; Uzun, Sevda; Türkmen, Osman Oğulcan

    Aim: This study aimed to evaluate the effects of three different music-based interventions on anxiety and fatigue levels in patients undergoing hemodialysis, compared to a concurrent control group receiving standard care. Methods: This randomized controlled trial involved 64 patients receiving maintenance hemodialysis. They were randomly assigned to four equal groups (n = 16 each): live music, live ney sound therapy (using a traditional reed flute known for its soothing, breath-like tones), a music-repeating robotic parrot therapy (an interactive robotic parrot that repeats music or sounds provided by the patient), or a control group (no intervention). The experimental groups received 30-min sessions 3 days per week for 2 months. The “Beck Anxiety Scale” and “Fatigue Severity Scale” were used to measure anxiety and fatigue, respectively. Assessments were performed before the intervention, immediately after the 2-month intervention period, and at 2 months after the end of the intervention period. Results: Before the intervention, there were no significant differences in anxiety or fatigue scores across the four groups (p > 0.05). After the interventions, all three groups exposed to music therapy showed significant reductions in both anxiety and fatigue scores compared to the control group (p < 0.001). Conclusion: All three therapies were effective in managing anxiety and fatigue symptoms in hemodialysis patients. Among them, music-repeating robotic parrot therapy demonstrated the most superior and longest-lasting effects in reducing both anxiety and fatigue levels. Trial Registration: ClinicalTrials.gov identifier: NCT07238374.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleAçık Erişim2026
    A comparative interventional study on the effectiveness of acceptance and commitment therapy, emotion-focused therapy, and attachment-based therapy in improving emotion regulation among adolescents with digital game addiction

    Güngör, Sunay

    Background: Digital game addiction is a rapidly developing social and mental health concern that is closely related to emotion regulation difficulties. The present study aimed to compare the effectiveness of acceptance and commitment therapy (ACT), emotion-focused therapy (EFT), and attachment-based therapy (ABT) in improving emotion regulation among adolescents with digital game addiction. Methods: The present study was an interventional study employing a pretest–posttest design and a control group. The sample included 100 adolescents aged 13–18 years who were diagnosed with gaming disorder according to the 11th Revision of the International Classification of Diseases (ICD-11) criteria. Participants were selected using purposive sampling and were assigned to four groups of 25 individuals each, including three experimental groups and one wait-list control group. The 7-item Digital Game Addiction Scale (DGAS-7) and the Regulation of Emotions Questionnaire among Adolescents (REQ-A) were used to gather data. ACT and EFT were administered in eight sessions, whereas ABT was delivered in 10 sessions. Data were analyzed using repeated measures ANOVA in SPSS. Results: It was found that the three therapeutic strategies produced a significant increase in functional emotion regulation scores (internal and external) and a significant decrease in dysfunctional emotion regulation scores compared to the control group (p < 0.001). However, the effect sizes for the ACT and EFT groups were very large compared to the ABT group. There was no significant difference between ACT and EFT; nevertheless, both interventions were significantly more effective compared to ABT at both the posttest and follow-up stages. Conclusion: ACT and EFT are more effective interventions for improving emotion regulation among adolescents with digital game addiction because of their emphasis on psychological flexibility and emotionally profound processing. Although ABT was found to be moderately effective, it can be used as an adjunctive therapy, particularly in cases involving relational problems.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleYalnız künye2026
    Germination as a Pre-isolation Modification Method for Common Buckwheat Protein Isolate

    Gülbahar, Esma; Tunç, Merve Tuğçe; Akdoğan, Arda; Baltacı, Cemalettin; Sarıcaoğlu, Furkan Türker; Parlak, Mahmut Ekrem; Aydın, Engin; Odabaş, Halil İbrahim

    This study investigated germination as a pre-isolation modification method to enhance the techno-functional and nutritional properties of common buckwheat (Fagopyrum esculentum Moench) protein. Germination was conducted at two different temperatures (20 and 30 °C) for 24, 48, and 72 h, and isolated proteins were analyzed for their chemical, structural, and functional properties. Results showed that the highest protein yield was achieved at 30 °C for 24 h, though durations exceeding 48 h reduced purity. SDS-PAGE and FTIR analyses confirmed that endogenous protease activity degraded high-molecular-weight proteins and increasing random coil proportions, indicating partial unfolding. SEM imaging revealed that germination transformed the dense protein surface into a porous morphology. Increasing germination time and temperature led to decreased lightness (L*) and hue angle, along with moderate increases in redness (a*), indicating notable changes in the visual appearance of the protein isolates. DSC results showed a decrease in thermal stability (Td) due to structural changes. In addition, germination significantly improved solubility, emulsifying activity, foaming capacity, and water/oil absorption, particularly at the 24 h of germination. Most notably, germination at 30 °C for 24 h increased in vitro protein digestibility from 75.67 to 82.19%. The results show that the germination is a promising approach to enhance the functionality and digestibility of buckwheat protein for potential application in food industry.

    • SDG 2 · Açlığa Son
    İncele
  • Editöre MektupAçık Erişim2026
    Reply to the Letter to the Editor: Assessing the Predictive Value of Kolmogorov–Arnold Networks for the No–Reflow Phenomenon in ST–Segment Elevation Myocardial Infarction: A Comparative Machine Learning Study; [Editöre Mektup Yanıtı: ST Segment Yükselmesi Miyokard Enfarktüsünde No–Reflow Fenomeni için Kolmogorov–Arnold Ağlarının Öngörü Değerinin Değerlendirilmesi: Karşılaştırmalı Makine Öğrenimi Çalışması]

    Taşolar, Hakan; Bayramoğlu, Adil; Günen, Mehmet Akif; Levent, Sümeyye; Güral, Yunus; Halisdemir, Nurhan

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleAçık Erişim2026
    The Effect of Fatigue During Search and Rescue Efforts in Debris on the Quality of Cardiopulmonary Resuscitation

    Çavuş, Kadir; Tiryaki, Oğuzhan; Tiryaki, Elif; Çelik, Suat; Saçar, Hüseyin Bora

    Objectives: Cardiopulmonary resuscitation (CPR), which is used in cases of life-threatening cardiopulmonary arrest, is a physically exhausting procedure. Adding to that, sometimes, even before performing CPR, interventions to rescue the injured person from a challenging environment have caused significant fatigue. In this study, taking a novel research approach, we generated a scenario of fatigue during a rescue from earthquake debris and aimed to measure the effect of that fatigue on the quality of CPR performed by paramedics. Methods: The research followed an experimental design with 2 groups (experimental/control) and 2 measurements (pretest/post-test). The study population was selected using power analysis. The sample, consisting of 84 paramedic students, was randomly divided into 42 control and 42 experimental participants. Current American Heart Association (AHA 2020) and European Resuscitation Council (ERC 2021) guidelines were strictly followed when performing CPR. In order to assess the accuracy of CPR, a General Doctor GD-CPR200S-A (2010 standard) simulator was utilized. The participants were fatigued by practicing the process of extracting and transporting earthquake victims from rubble. A personal information form with 20 questions and a CPR measurement form were used to obtain the data. Results: In the analysis performed to measure the differences between the CPR indicators for the control and experimental groups in the post-test and pretest, the difference in compression (control: 6.5 ± 50.1 and experimental: −10.3 ± 46.0) was not significant. Meanwhile, we found that the difference in ventilation (control: 0.3 ± 5.4 vs. experiment: 8.1 ± 4.6) and the difference in CPR completion times (control: 0.2 ± 1.2 vs. experiment: −0.7 ± 0.7) between the post-test and pretest were significant. Conclusions: There was no significant difference in correct compressions between the control and experimental groups, but there was a significant difference in ventilation and CPR completion times. For this reason, it is recommended to focus on the effect of fatigue on CPR quality, especially on the ventilation process. It is also recommended to include fatigue scenarios in CPR trainings.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleYalnız künye2026
    Phytochemical profiling, biological activities, and molecular docking analysis of Dorycnium pentaphyllum subsp. haussknechtii

    Ayna, Adnan; Hakan, Oguzhan; Yapıcı, İsmail; İzol, Ebubekir; Yılmaz, Mustafa Abdullah; Necip, Adem; Yapar, Yakup

    BACKGROUND: In the current study, the biological activity fingerprint of Dorycnium pentaphyllum subsp. haussknechtii was investigated by an interdisciplinary approach through analysis of its phytochemical content, antioxidant capacity, enzyme inhibitory potential and molecular docking. RESULTS: The analysis of the phytochemical content by liquid chromatography–tandem mass spectrometry was characterized by the presence of flavan-3-ols, such as epicatechin, epigallocatechin, and catechin, as well as quercetin-derived flavonoids such as isoquercitrin. Analysis of the antioxidant capacity by 2,2-diphenyl-1-picrylhydrazyl, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), ferric reducing antioxidant power, Fe3+–Fe2+ reducing and cupric reducing antioxidant capacity methods indicated the strong antioxidant capacity of the plant extract. In addition, the plant extract was able to modulate biological enzyme activity effectively, with IC50 values of 111.78 μg mL−1 for acetylcholinesterase, 22.07 μg mL−1 for butyrylcholinesterase, 1.39 μg mL−1 for α-glucosidase, 7.34 μg mL−1 for carbonic anhydrase I, and 17.41 μg mL−1 for carbonic anhydrase II. To have a better understanding of the molecular mechanism for the plant extract's properties, the major phenolic compounds present in the plant extract were investigated for molecular docking with their respective enzymes. As such, the results revealed a strong binding affinity and conformational stability, with strong hydrogen bonding and π–π interactions. CONCLUSION: Generally, the properties revealed by the plant extract indicate that the phenolic content, strong antioxidant properties, and enzyme inhibition activity of D. pentaphyllum subsp. haussknechtii have shown great potential for being a useful natural source for therapeutic lead compounds.

    İncele
  • MakaleAçık Erişim2026
    Synthesis, Characterization, Biological Properties, and Sensor Applications of Novel Thiosemicarbazone Derivatives

    Gezegen, Hayreddin; Özbek, Oguz; Topal, Meryem; Şahin, Hatice; Koçyiğit, Ümit M.

    In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and acetylcholinesterase (AChE). The hCA I II, and AChE were efficiently inhibited by synthesized thiosemicarbazone derivatives, with Ki values in the range of 0.293–1.666 µM for hCA I, 0.298–1.332 µM for hCA II, and 52.51–138.63 µM for AChE, respectively. Finally, the sensor properties of the synthesized thiosemicarbazone derivatives were investigated. The newly synthesized thiosemicarbazone derivative molecules exhibited high selectivity towards Pb2+ ions. The sensor prepared with 5a from these molecules had a Nernstian behavior of 28.8 ± 1.5 mV/decade and a low detection limit of 2.86 × 10−6 M in a wide concentration range of 1.0 × 10−1–1.0 × 10−5 M. The newly proposed sensor also had a wide pH working range (5.0–10.0), a very fast response time (5 s), and good reproducibility. The newly fabricated sensors were used as indicator electrodes for the potentiometric titration of Pb2+ ions with ethylenediaminetetraacetic acid (EDTA) and were successfully applied for the determination of Pb2+ ion content in different water samples.

    İncele
  • MakaleAçık Erişim2026
    Factors affecting hospital personnel’s disaster management performance

    Kaya, Burak; Mızrak, Sefa

    Background: Hospital personnel with strong disaster management skills will work effectively and efficiently during disasters, ensuring better health services for staff, patients, and injured individuals. Purpose: This study aimed to investigate the factors affecting the hospital personnel disaster management performance (HPDMP) of Giresun Training and Research Hospital (Türkiye) according to the opinions of all hospital personnel. Method: In this study, survey data were collected from 797 hospital personnel between July and August 2023. HPDMP was employed as a dependent variable. Demographic characteristics, working conditions of personnel, disaster education, awareness of hospital disaster plans, and hospital disaster plan duty were used as independent variables. In addition, the arrangement of the hospital in relation to disaster risks, personnel self-efficacy, personnel coordination, coordination with other institutions, and disaster preparedness were also employed as independent variables. Results: The hospital’s disaster management performance was good. Personnel who received sufficient disaster education and had more knowledge about hospital disaster plans believed that HPDMP was greater. According to hospital personnel, disaster preparedness and coordination with other institutions were the factors that most strongly increased HPDMP. Conclusion: This study will provide insight for scientists, decision makers, and practitioners working in the field of hospital disaster planning and management.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleYalnız künye2026
    Financial Simulation of Remote Healthcare Implementation Strategies in Türkiye: A Monte Carlo Analysis Based on Specialty-Specific Eligibility

    Demir, Hüseyin; Akar, Tuncay; Mertoğlu, Süleyman; Burmaoğlu, Serhat; Tekinarslan, Merve

    The expansion of universal health coverage in Türkiye has intensified pressure on public healthcare providers through high outpatient volumes that strain capacity and financial sustainability. Remote healthcare delivery has emerged as a potential strategy to improve efficiency and access. However, limited evidence exists on how remote outpatient care should be implemented across medical specialties within a universal payer system, or how alternative implementation strategies perform financially. This study evaluates the specialty-specific feasibility and financial impact of remote outpatient care using comprehensive administrative data from a large public training and research hospital in Izmir, supplemented by qualitative input from clinical specialists. The analysis includes 577,984 outpatient visits recorded in 2022 across major medical specialties. Eligibility for remote delivery is identified using observable clinical proxies—imaging requests, laboratory tests, and prescription issuance—to capture visits not requiring physical examination or procedural intervention. Results show that 121,248 visits (21.0%) are suitable for remote delivery, accounting for 16.2% of expenditures ($0.68 million out of $4.20 million). Remote eligibility varies substantially across specialties, with high suitability in dermatology and infectious diseases but limited applicability in device-dependent fields such as pulmonology. Four implementation scenarios are simulated over a 10-year horizon: Regulatory Compliance, Evidence-Based Specialty-Specific, Follow-Up Only, and Hybrid Progressive. The Regulatory Compliance scenario yields the shortest break-even period (3 years) and highest ROI (1185%). The Hybrid Progressive scenario, incorporating phased specialty expansion and AI-supported triage, requires higher upfront costs but generates the largest cumulative net savings ($1.39 million). The findings demonstrate that financially sustainable remote outpatient care can be achieved through carefully designed, specialty-specific implementation strategies.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • Derleme MakaleAçık Erişim2026
    Postbiotics in Dairy: A Comprehensive Review of Applications and Health Impacts

    Kaya, Yasemin; Aktaş, Haktan; Meral-Aktaş, Hacer; Ürkek, Bayram; Gürbüz-Kaçan, Zeynep; Çiftçi, Esengül; Erkaya-Kotan, Tuba; Şengül, Mustafa; Çetin, Bülent

    Purpose of Review: This review aims to provide a comprehensive overview of postbiotics—defined as non-viable microbial cells, cell components, and microbial metabolites—and their emerging role in dairy products. It focuses on their functional, technological, and health-promoting properties in various dairy matrices, including yoghurt, cheese, kefir, fermented milk, and ice cream. Additionally, the review highlights the potential of postbiotics as stable and safe alternatives to probiotics in the development of functional dairy foods. Recent Findings: Recent evidence demonstrates that postbiotics such as exopolysaccharides (EPS), bacteriocins, short-chain fatty acids (SCFAs), bioactive peptides, and organic acids significantly enhance both the nutritional value and technological quality of dairy products. These compounds have been shown to improve texture, sensory attributes, shelf life, and microbial safety while exerting biological activities, including antimicrobial, antioxidant, immunomodulatory, and gut health–promoting effects. Compared with probiotics, postbiotics offer greater stability during processing and storage as well as reduced safety concerns, particularly for vulnerable populations. Summary: Postbiotics represent a promising strategy for advancing functional and sustainable dairy products by combining health benefits with technological improvements. Their applications in functional food formulation, biopreservation, and bioactive compound delivery are rapidly expanding. However, challenges remain regarding standardised production processes, accurate quantification of bioactive components, and clinical validation of health claims. Future research should focus on optimising postbiotic production and strengthening evidence for their physiological effects to support their broader incorporation into next-generation dairy products.

    • SDG 2 · Açlığa Son
    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleYalnız künye2026
    In sepsis-associated cardiotoxicity, remifentanil reduces oxidative stress, inflammation, and apoptosis to maintain mitochondrial biogenesis by inhibiting NFkB and cas-3 immunoexpressions and enhancing SIRT1 upregulation

    Tepebaşi, Muhammet Yusuf; Aşci, Halil; Selçuk, Esma; Uysal, Dinçer; Bindal, Ahmet; Yüksel, Duygu; Özmen, Özlem

    Objective: Sepsis-induced cardiotoxicity (SIC) is a critical complication characterized by inflammation, oxidative stress, and apoptosis, leading to myocardial dysfunction. The short-acting opioid analgesic remifentanil (REMI) possesses antioxidant and anti-inflammatory properties. This study aimed to evaluate the cardioprotective effects of REMI on lipopolysaccharide (LPS)-induced SIC by examining inflammation, oxidative stress, apoptosis, and mitochondrial function. Materials and methods: Thirty-two female Wistar albino rats were divided into four groups: control, lipopolysaccharide (LPS), LPS+REMI, and REMI. Myocardial and aortic tissues were analyzed for histopathology, immunoexpression of Caspase-3 (Cas-3), nuclear factor kappa beta (NF-κB), and tumor necrosis factor alpha (TNF-α). Oxidative stress markers, including total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI), were measured. Mitochondrial apoptosis-related gene expression of AMP-activated protein kinase (AMPK), BCL2 Associated X (BAX), B-cell lymphoma 2 (BCL-2), Sirtuin 1 (SIRT1), and Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) was assessed. Results: LPS administration induced severe histopathological damage, increased oxidative stress (elevated TOS and OSI), and upregulated apoptotic (Cas-3, BAX/BCL-2 imbalance) and inflammatory (NF-κB, TNF-α) markers. REMI treatment significantly alleviated myocardial and aortic injury, reducing the histopathological score. It markedly decreased Cas-3, NF-κB, and TNF-α expression, lowered TOS and OSI levels, and modulated the BAX/BCL-2. Furthermore, REMI restored the expression of AMPK, SIRT1, and PGC-1α genes, indicating a protective effect on mitochondrial biogenesis and energy metabolism. Conclusions: REMI exhibits significant cardioprotective effects in LPS-induced SIC by attenuating inflammation, oxidative stress, and apoptosis while preserving mitochondrial homeostasis.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleAçık Erişim2026
    Effects of psychosocial interventions on sexual function, quality of life, and stress in women with gynecologic cancer: a systematic review and meta-analysis

    Aydın, Esra; Özcan, Handan; Karakaş, Sevda; Uzun, Sevda

    Objectives: To evaluate the effects of psychosocial interventions on sexual function, quality of life, and stress levels in women with gynecologic cancer. Methods: This systematic review and meta-analysis was conducted in accordance with the PRISMA 2020 guidelines. PubMed, Web of Science, EBSCOhost, Google Scholar, and the YÖK Thesis Center were searched between June and July 2024 without year restriction. Randomized controlled and quasi-experimental studies evaluating psychosocial interventions were included. Data were synthesized using meta-analysis and narrative synthesis. Outcomes were synthesized separately for sexual function, quality of life, and stress. Results: Seven studies were included in the analysis. Psychosocial interventions significantly improved sexual function (SMD: 0.868; 95% CI: 0.021 to 1.715; Z = 2.008; p = 0.045; I2 = 89.97%) and quality of life (SMD: 0.709; 95% CI: 0.060 to 1.358; Z = 2.142; p = 0.032; I2 = 88.61%) in women with gynecologic cancer. However, psychosocial interventions did not demonstrate a significant effect on stress levels (SMD: − 1.126; 95% CI: − 2.649 to 0.397; Z = − 1.449; p = 0.147; I2 = 95.65%). Conclusion: This systematic review and meta-analysis indicates that psychosocial interventions are associated with improvements in sexual function and quality of life among women with gynecologic cancer, whereas no statistically significant reduction in stress was observed. Although substantial between-study heterogeneity was present, the overall evidence supports the integration of psychosocial approaches into supportive oncology nursing care.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleAçık Erişim2026
    Biochemical Profiles of Three Bryophytes: Sphagnum papillosum, Rhytidiadelphus triquetrus, and Ditrichum gracile

    Okan, Onur Tolga; Baltaci, Cemalettin

    This study compared Sphagnum papillosum, Rhytidiadelphus triquetrus, and Ditrichum gracile in terms of total phenolic content (TPC), total flavonoid content (TFC), antioxidant activities (DPPH, ABTS, ferric reducing antioxidant power [FRAP]), phenolic profiles, fatty acid compositions, and mineral contents. S. papillosum had the highest TPC (986.11 mg GAE/kg) and ABTS activity (9732.14 mg Trolox/kg). R. triquetrus showed the highest TFC (874.01 mg QE/kg) and was rich in protocatechuic (18 803 mg/g) and 4-hydroxybenzoic acids (23.219 mg/g). Although D. gracile had lower antioxidant activity, it contained high lipid (6.71%) and ash (27.66%) levels, along with substantial potassium (73 573.86 mg/kg) and calcium (26 135.94 mg/kg) accumulation. Palmitic acid (C16:0) was the dominant fatty acid in all species. These results demonstrate significant biochemical variation among the studied mosses, underlining their potential as sources of natural antioxidants, bioindicators of environmental stress, and candidates for bioremediation.

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  • MakaleYalnız künye2026
    Surrogate Trauma in Nurses Providing Pediatric Palliative Care: A Phenomenological Study

    Oğuzhan, Hatice; Akay, Gamze; Uzun, Sevda; Koç, Elif Simay; Öncer, Aysun

    The aim of this study was to deeply examine the experiences of proxy grief among nurses providing pediatric palliative care. This qualitative phenomenological study was conducted with 16 nurses working in the pediatric ward of a hospital located in the northern region of the country. Data were analyzed using Colaizzi’s phenomenological analysis method. The analysis revealed 3 themes (challenges experienced while caring for children in palliative care; secondary trauma and coping processes; proxy trauma and professional resilience) and 9 sub-themes (emotional strain during care, establishing an empathetic bond, emotional exhaustion, traumatic experiences, seeking psychological support, religious coping methods, developing a professional approach, resilience and acceptance, and motivation to continue in the profession). The study found that nurses providing pediatric palliative care experienced significant psychosocial stress. Pediatric nurses were particularly challenged emotionally when caring for palliative patients. In this context, it is important to develop stress-coping skills to help nurses manage vicarious trauma. Strengthening nurses psychologically and spiritually will positively impact their professional lives, which in turn will enhance the quality of care they provide.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleAçık Erişim2026
    Between Survival and Sacrifice: Marital Experiences of Patients Undergoing Hemodialysis

    Çakmak, Seher; Karataş, Hicran

    The study aimed to explore the lived experiences of married dialysis patients on the national organ waiting list, focusing on the interplay between illness, familial roles, and societal norms. This research is a qualitative study using semi-structured interviews and participant observation. The study involved 23 marriage-experienced hemodialysis-dependent patients (13 women, 10 men) on the national organ waiting list, recruited between August 16 and November 11, 2022. Data were collected through interviews and observations and were analyzed thematically to identify recurring patterns. Chronic kidney disease (CKD) poses significant physical, psychological, and social burdens, particularly for hemodialysis-dependent patients. Five main themes emerged from this study: (1) When Care Becomes a Test, (2) Dealing with Social Isolation, (3) Sacrifices to Sustain the Marriage, (4) Uninvited voices, (5) Resentful but Thankful. These findings highlight the need for family-centered care that considers diverse family structures and social contexts, while also demonstrating the impact of prolonged hemodialysis (HD) and marital strain on emotional and sexual intimacy.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele