Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(46)
- Kulakaç, Nurşen(21)
- Aydin, Aydanur(16)
- Demir, Selim(16)
- Tuncer, Metin(16)
- Topal, Fevzi(15)
- Turan, Ibrahim(15)
- Yilmaz, Coskun(14)
- Bayrakdaroglu, Serdar(12)
- Koçak, Tevfik(11)
- Aliyazicioglu, Yuksel(10)
- Gulcin, Ilhami(10)
- Ozturk, Samet(10)
- Topal, Meryem(10)
- Ceylan, Halil Ibrahim(9)
- Ceylan, Levent(9)
- Kilinc, Kagan(9)
- Mentese, Ahmet(9)
- Ozdes, Duygu(9)
- Tuncer, Gülsüm Zekiye(9)
- Duran, Celal(8)
- Emirza, Elif Güzide(8)
- Yaman, Serap Ozer(8)
- Yılmaz, Coşkun(8)
- Baltacı, Cemalettin(7)
- Demirağ, Hatice(7)
- Hintistan, Sevilay(7)
- Kaya, Feridun(7)
- Küçük, Murat(7)
- Ürkek, Bayram(7)
- Şengül, Mustafa(7)
- Bayrakdaroğlu, Serdar(6)
- Deger, Orhan(6)
- Genc, Berna(6)
- Gül, Abdulkadir(6)
- Gülçin, Ilhami(6)
- Günen, Mehmet Akif(6)
- Gürsoy, Ayla(6)
- Kurnaz, Muammer(6)
- Supuran, Claudiu T.(6)
Yayınlar
- MakaleAçık Erişim2025Scopus SJRQ2Inspiratory muscle training in natural bodybuilders: adaptations in diaphragm muscle thickness and maximal strength
Güler, Iskender; Yilmaz, Coskun; Soylu, Hakan Hueseyin; Birinci, Muersit Ceyhun; Arslan, Ayla; Ocak, Hakan; Çayir, Huseyin; Kavuran, Korhan; Saç, Ajlan; Uçar, Mine Akkus
Background: The effect of inspiratory muscle training on diaphragm muscle thickness (DT) and one repetition maximal (1RM) in professional natural bodybuilders is still unclear. The aim of the study was to investigate the effect of inspiratory muscle training on diaphragm muscle thickness and 1RM in professional natural bodybuilders. Methods: The study comprised a total of 22 athletes who participated in bodybuilding competitions. Each athlete had undergone a minimum of 5 years of training, with a minimum weekly commitment of 5 hours. Participants were randomly divided into two groups: inspiratory muscle training (IMT) and control (CON). The CON continued their normal training regime, while the IMT group also performed inspiratory muscle training with a 10% weekly increase by setting the resistance setting of the PowerBreathe (R) Classic device to 40% of the participant's maximum inspiratory pressure (MIP). Prior to and during the 4-week training period, 1RM bench press measurements and diaphragm muscle thickness measurements were obtained. Results: In the comparison of 1RM power values before and after training, it was determined that the IMT group (%: 11.20) had 6.3% more post-activation performance enhancement compared to the CON group (%: 4.9) (p < 0.001). In the study, it was determined that a higher level of significant post-activation performance enhancement was obtained in the IMT group compared to the CON group in the diaphragm muscle thickness inspiratory phase (DT ins) and ekspiratory phase (DT eks) parameters at 20.36% and 19.46%, respectively. Conclusion: In conclusion, we determined that the addition of progressive loading inspiratory muscle training to preparation programmes in natural bodybuilders will improve diaphragm muscle thickness, 1RM physical performance. In particular, it shows that the diaphragm muscle should be considered not only as a muscle that supports respiration, but also as a muscle that contributes to power generation by optimising intra-abdominal pressure.
AtıfScopus5WoS5OpenAlex5
İncele - MakaleAçık Erişim2025Scopus SJRQ1Judo exercises increase emotional expression, self-control, and psychological resilience
Köroglu, Mihrac; Yilmaz, Coskun; Tan, Cetin; Çelikel, Baha Engin; Budak, Cemalettin; Kavuran, Korhan; Susuz, Yunus Emre; Barut, Yasar; Ceylan, Tulay; Soyer, Fikret
Background: The extant research on judo sports has principally concentrated on the physiological effects of training. Conversely, there has been limited attention paid to studies on psychological resilience, self-control, and emotional expression levels. The present study examined the effects of Judo exercises on psychological resilience, self-control, and emotional expression levels in healthy male subjects. Methods: The present study comprised 50 healthy, sedentary male subjects. The subjects were randomly divided into two groups: one group participated in judo training (JT) and the other group served as the control group (CON). The sample sizes for the JT and CON groups were both 25. The JT group underwent judo training, while the CON group maintained their usual lifestyle. The Brief Psychological Resilience Scale, the Multidimensional Brief Self-Control Scale, and the Berkeley Emotion Expression Scale were administered prior to and following the 6-week training period. Results: The study demonstrated that a 6-week judo training regimen exerted a significant effect on the psychological resilience score (e.s. = 1.047, p < 0.001), while no such effect was observed in the Control group (e.s. = 0.0091, p = 0.751). In the context of self-control levels, an effect was observed on the Initiation sub-dimension (e.s. = 1, 739, p < 0.001), yet no effect was found on the Inhibition dimension (e.s. = 0.052, p = 0.892). In the control group, a significant decrease was identified in the Initiation sub-dimension (e.s. = 0, 785, p = 0.001) and Inhibition sub-dimension (e.s. = 1, 861, p < 0.001). The findings indicate that impulse power (e.s. = 0.395) and concealment (e.s. = 0.428) exerted a negligible influence on the emotional expression sub-dimensions. Conversely, psychological resilience (e.s. = 0.886) demonstrated a substantial impact. Conclusions: The judo exercises demonstrated a favorable impact on psychological resilience, self-control, and emotional expression levels in healthy male subjects. The findings of this study may offer significant insights into the impact of judo exercises on psychological resilience, self-control, and emotion expression levels. These findings could serve as a guide for the development of future interventions and program design in the domain of sport psychology.
AtıfScopus9WoS10OpenAlex11İncele - MakaleAçık Erişim2025Scopus SJRQ1Exploring how cognitive-behavioral physical activity links ruminative thinking and mental wellbeing in sports high school adolescents
Derelioglu, Mehmet; Vural, Mustafa; Çimen, Erkan; Saki, Unal; Yagiz Saracoglu, Yusuf; Karatas, Baykal; Saç, Ajlan; Yamaner, Emre; Halmatov, Medera; Yilmaz, Coskun
Introduction: This study examined the associations among ruminative thinking style (RTS), subjective wellbeing (SWB), and cognitive-behavioral physical activity (CBPA) in a sample of 1,326 adolescents (aged 14-18) from sports high schools. Method: Using validated self-report measures, data were analyzed through bootstrapped mediation models. Results: RTS was negatively associated with SWB (beta = -0.1792, p < 0.001), while CBPA showed a partial mediating effect in this relationship (indirect beta = 0.0779, p < 0.001). Discussion: These results suggest that cognitive-behavioral orientations toward physical activity may buffer the negative impact of rumination on wellbeing. Consistent with cognitive-behavioral therapy (CBT) principles, CBPA could provide adolescents with self-regulatory strategies that support mental health. However, the cross-sectional and self-report design, as well as the focus on sports high school students, limit causal inference and generalizability. Future longitudinal and cross-cultural studies are needed to confirm these findings. Overall, the study provides preliminary evidence that CBPA-informed approaches may hold promise for promoting adolescents' mental wellbeing.
AtıfScopus12WoS10OpenAlex11İncele - MakaleAçık Erişim2025Scopus SJRQ1The effects of sub-components of economic freedom on load capacity factor: Empirical analysis for MENA countries
Senturk, Nazli Keyifli; Bayraktar, Yuksel; Recepoglu, Mursit; Ozyilmaz, Ayfer; Balsalobre-Lorente, Daniel
This study investigates the effects of economic freedom sub-components on load capacity factor (LCF) in 12 MENA countries for 2017-2022. The 12 sub-components of the economic freedom index were used as independent variables, and the load capacity factor was used as the dependent variable. In the study, four-panel data models were created using the subcomponents of the economic freedom index, and a two-stage System-GMM was used. According to the study, while property rights reduce the load capacity factor, Judicial Effectiveness increases it. The effect of Government Integrity on the load capacity factor is statistically insignificant. While Government spending negatively affects the load capacity factor, Tax Burden and Fiscal Health are statistically insignificant. Business freedom affects the load capacity factor positively, but monetary freedom affects it negatively. Labour freedom is statistically insignificant. On the other hand, trade freedom and investment freedom have a positive impact on the load capacity factor, while financial freedom has a negative effect.
AtıfScopus8WoS7OpenAlex8İncele - MakaleAçık Erişim2025Scopus SJRQ1Sulfonamide-Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME/T Profiling and Molecular Docking Study
Lolak, Nebih; Akocak, Suleyman; Topal, Meryem; Koçyigit, Umit Muhammet; Isik, Mesut; Türkes, Cuneyt; Topal, Fevzi; Durgun, Mustafa; Beydemir, Sukru
The research and design of new inhibitors for the treatment of diseases such as Alzheimer's disease and glaucoma through inhibition of cholinesterases (ChEs; acetylcholinesterase, AChE and butyrylcholinesterase, BChE) and carbonic anhydrase enzymes are among the important targets. Here, a series of novel sulfonamide-bearing pyrazolone derivatives (1a-f and 2a-f) were successfully synthesized and characterized by using spectroscopic and analytical methods. The inhibitory activities of these newly synthesized compounds were evaluated both in vitro and in silico for their effect on carbonic anhydrases (hCA I and hCA II isoenzymes) and ChEs. The in vitro studies showed that these novel compounds demonstrated potential inhibitory activity, with K-I values covering the following ranges: 18.03 +/- 2.86-75.54 +/- 4.91 nM for hCA I, 24.84 +/- 1.57-85.42 +/- 6.60 nM for hCA II, 7.45 +/- 0.98-16.04 +/- 1.60 nM for AChE, and 34.78 +/- 5.88-135.70 +/- 17.39 nM for BChE. Additionally, many of these compounds showed promising inhibitory activity, and some showed higher potency than reference compounds. While the in silico studies have also identified the potential binding positions of these compounds, using the crystal structures of hCA I, II, AChE and BChE receptors. The varying affinities demonstrated by these designed compounds for ChEs and hCA isoenzymes show that these compounds could hold promise as potential alternative agents for selectively inhibiting ChEs and hCAs in the treatment of diseases such as Alzheimer's disease and glaucoma.
AtıfScopus21WoS22OpenAlex21İncele - MakaleAçık Erişim2025Scopus SJRQ2Maximizing performance in child footballers: chronotype and time of day study
Kaba, Ilknur; Engin Celikel, Baha; Adanur, Oguzhan; Yilmaz, Coskun; Yonca Sezer, Sureyya; Tan, Cetin; Durhan, Tebessum Ayyildiz; Özer, Ugur; Ceylan, Tulay
Background A limited number of studies have investigated the effects of circadian rhythm-based running exercise interventions on physical fitness in child athletes. This study aimed to investigate the effects of an eight-week morning and evening running program on lower extremity strength, agility and respiratory function in 10-12-year-old male footballers.Methods Participants visited the laboratory three times, with one-day intervals before and after the training program. The assessments included maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio. Additionally, agility and functional performance tests (FPTs) were conducted for both the dominant and non-dominant legs.Results The findings indicated that morning running was more effective than evening running in enhancing respiratory function. Morning running also showed superior results in lower extremity strength tests, particularly in the single-leg (SL) and triple-leg (THD) crossover hop for distance tests (CHDs) and the 6-m timed-hop test (6 m THT). Furthermore, the agility performance of the morning running group was significantly better than that of the evening and control groups.Conclusion Consequently, morning running interventions had a positive impact on key physical fitness parameters, including respiratory muscle strength, respiratory function, agility, and lower extremity strength in child footballers.
- MakaleYayıncıda açık erişim2025Scopus SJRQ2Could Different Doses of Dexmedetomidine Be as Effective as Amifostine Against Radiotherapy-Induced Liver Injury in Rats? Evidence from Mitotic, Apoptotic, Oxidative, and Neurogenic Insights
Beyazal Polat, Hatice; Yilmaz, Hamit; Demir, Kasim; Kilinc, Kagan; Gülhan, Belemir; Rakici, Sema Yilmaz; Tumkaya, Levent
Background/Objectives: Radiotherapy (RT) induces oxidative stress and structural damage in solid tissues, including the liver. This study aimed to investigate the histological and immunohistochemical effects of dexmedetomidine (DEX) and amifostine on their potential protective and regenerative properties against liver injury induced by radiation therapy. Methods: This study consisted of five randomized groups: control, RT, RT-D100, RT-D200, and RT-A (Amifostine). A total of 100 mu g/kg DEX, 200 mu g/kg DEX, and 200 mu g/kg amifostine were administered before radiotherapy as per the experimental design. After RT, liver specimens were analyzed for histological alterations, including periportal and perisinusoidal fibrosis, vacuolization, and pyknotic nuclei. Furthermore, immunohistochemistry investigations were conducted to evaluate apoptosis, mitosis, oxidative stress, and neural regeneration in non-neuronal liver tissue following radiotherapy and subsequent treatment. Results: The control group's liver tissue exhibited standard histological architecture, whereas the RT group displayed severe cellular degeneration, periportal and perisinusoidal fibrosis, cytoplasmic vacuolization, and an increase in pyknotic nuclei. The apoptotic index was markedly reduced in the RT-D100 and RT-D200 groups relative to the RT group. Furthermore, caspase-3 immunoactivity was negligible in the control group, while a significant increase was observed in the RT group. The administration of amifostine significantly increased GAP-43 levels. Conclusions: DEX mitigates RT-induced hepatic injury chiefly through antioxidant and anti-apoptotic pathways, whereas amifostine promotes hepatic regeneration by modulating GAP-43.
- MakaleAçık Erişim2025Scopus SJRQ2Effect of Inspiratory Muscle Training on Diaphragm and Abdominal Wall Muscle Thickness with Fatty Liver Density in Elderly Women: A Randomized Controlled Trial
Gökçelik, Eda; Yilmaz, Coskun; Budak, Cemallettin; Soylu, Hakan Huseyin; Bayrakdaroglu, Serdar; Ceylan, Halil Ibrahim; Muntean, Raul Ioan; Küçük, Hamza; Ceylan, Levent
Background and Objectives: Post-menopausal estrogen decline is considered a contributing factor to sarcopenia, and inspiratory muscle training (IMT) may provide benefits in this demographic. This study examined the impact of a four-week IMT program on diaphragm thickness, abdominal wall muscle thickness (AWMT; transversus abdominis, internal oblique, and external oblique), and liver fat percentage in healthy elderly women. Materials and Methods: Twenty-six women aged 60-80 years were randomly assigned to an IMT group (n = 13) or a control group (n = 13). The IMT group used the PowerBreathe (R) Classic device at 40% of maximal inspiratory pressure (MIP), with weekly increments of 10%. Training was performed twice daily, five days per week, with 30 breathing cycles per session (60 per day). The control group maintained their usual routines. AWMT, diaphragm thickness (DT), and fatty liver density (FLD) were measured by a radiologist before and after the intervention. Results: After four weeks, the IMT group showed significant improvements in all parameters compared to controls. Mid-diaphragm thickness (MDT) increased by 11.44% (effect size (ES) = 0.358, p < 0.001) versus 0.76% in controls (p = 0.271). Posterior diaphragm thickness (PDT) improved by 7.48% (ES = 0.282, p < 0.001) versus 0.38% (p = 0.564). Right AWMT increased by 12.7% (ES = 0.492, p < 0.001) compared to 0.10% (p = 0.872), and left AWMT increased by 9.93% (ES = 0.395, p < 0.001) versus 2.64% (p = 0.014). FLD improved by 11.79% (ES = 0.959, p < 0.001) in the IMT group, while the control group showed no meaningful change (-0.13%, p = 0.847). Conclusions: A short-term IMT protocol significantly enhanced diaphragm and AWMT and reduced liver fat in elderly women. These findings support the use of IMT as a simple, non-invasive intervention to preserve musculoskeletal and metabolic health in aging populations.
AtıfScopus4WoS4OpenAlex6İncele - MakaleAçık Erişim2025Scopus SJRQ1Taekwondo exercises for women improve quality of life, physical self-defence skills, and psychological resilience
Yikilmaz, Ahmet; Yilmaz, Coskun; Çiçekli, Atif; Eryilmaz, Onder; Budak, Cemalettin; Uyar, Musa; Ceylan, Tulay; Güler, Ozkan; Sahin, Fatma Nese
Background: The extant research on Taekwondo has focused primarily on the physiological effects of training, with limited interest in psychological resilience, self-defence and quality of life levels. The present study examined the effects of Taekwondo exercises on psychological resilience, self-defence and quality of life levels in healthy female subjects. Methods: The present study comprised 30 healthy, sedentary female subjects. The subjects were randomly divided into two groups: one group participated in Taekwondo training (TG), while the other group served as the control group (CG). The sample sizes for both the TG and CG groups were 15. The TT group underwent conventional Taekwondo instruction, while the CG group maintained their habitual routine and refrained from sporting pursuits. The Brief Psychological Resilience Scale, the Physical Self-Defence Scale for Women, and the SF-12 Quality of Life Scale were administered before and after the six-week training period. Results: The 6-week Taekwondo training programme led to significant improvements in both physical health (PH) (p = 0.049) and mental health (MH) (p < 0.01) scores in female participants. It did not produce a significant change in psychological resilience (PR) scores (p > 0.05). It produced significant improvements in self-defence against simple physical attacks (SP) (p = 0.004) and self-defence against dangerous physical attacks (DP) (p = 0.041) scores. Conclusion: The positive effects of Taekwondo training on psychological resilience, physical self-defence and quality of life levels have been demonstrated in healthy female subjects. This study provides valuable insights into the impact of Taekwondo exercises on psychological resilience, physical self-defence and quality of life levels. The findings of this study can guide future intervention and programme design in the context of sports psychology.
AtıfScopus2WoS4OpenAlex4İncele - MakaleAçık Erişim2025Scopus SJRQ1Short-term resistance training enhances functional and physiological markers in older women: implications for biomechanical and health interventions in aging
Uçar, Mine Akkus; Yilmaz, Coskun; Soylu, Hakan Huseyin; Sariakçali, Baris; Budak, Cemalettin; Kavuran, Korhan; Durmusoglu, Mehmet Vakif; Ceylan, Levent
Background: The impact of resistance training extends beyond the enhancement of muscle strength, encompassing improvements in physical performance, postural stability, and overall functional capacity. This study aimed to investigate the effects of a 4-week resistance training program on functional capacity, respiratory muscle strength, diaphragm thickness, and liver density in healthy older women. Methods: The study included 30 healthy women aged 60-80 years and was designed as a randomized controlled experimental trial. Participants were randomly assigned to a resistance training (RT) group or a control (CON) group. Each participant attended the laboratory on three occasions: during the initial visit, the study procedures were explained; the second visit involved baseline assessments (6MWT, diaphragm thickness and liver fat via ultrasound, and respiratory muscle strength); and final measurements were conducted after the 4-week training programme during the third visit. Results: When pre- and post-training measurements were compared, the resistance training (RT) group demonstrated a significantly greater improvement (8.02%) in the Six-Minute Walk Test (6MWT) distance compared to the control group (p < 0.001). In terms of diaphragm thickness (DT), the RT group showed a 16.66% increase, whereas the control group exhibited a 1.13% decrease (p < 0.001). Maximal inspiratory pressure (MIP) increased by 12.30% in the RT group, while it decreased by 7.25% in the control group, indicating a 19.55% greater improvement in the RT group (p < 0.001). Regarding maximal expiratory pressure (MEP), a significant improvement of 21.48% was observed in the RT group, whereas a 0.75% decrease was recorded in the control group, resulting in a 22.23% greater enhancement in the RT group (p < 0.001). Finally, liver density (LD) increased by 12.30% in the RT group, while it decreased by 7.25% in the control group (p < 0.001). Conclusion: As a result of resistance training, greater improvement was observed in functional capacity, respiratory muscle strength, diaphragm thickness and liver density in the training group compared to the control group.
AtıfScopus2WoS1İncele - MakaleYayıncıda açık erişim2025Scopus SJRQ2Serum neopterin and kynurenine as predictive and prognostic biomarkers in prostate cancer: the role of dietary inflammatory index and biomarker interactions
Icer, Mehmet Arif; Koçak, Tevfik; Acar-Tek, Nilufer; Yesil, Suleyman; Icer, Yusuf
Background It has been shown that neopterin levels in various body fluids can help predict the diagnosis of different malignancies. Although many studies have investigated the roles of serum neopterin concentrations, tryptophan metabolism, and the dietary inflammation index (DII) in various cancers, the connection between these factors and prostate cancer (PC) remains uncertain. The aim of this study was to investigate the predictive and prognostic roles of serum neopterin, and kynurenine levels, along with the kynurenine-to-tryptophan ratio (KTR) and DII in prostate cancer. Methods This study was conducted with 57 newly diagnosed prostate cancer patients, 55 benign prostate hyperplasia patients, and 56 healthy male individuals in the control group, all aged 40 years and older. Participants had specific anthropometric measurements taken, and three-day food records were kept. DII was calculated based on data for thirty-four available nutrients by using food records. Serum levels of neopterin, kynurenine, tryptophan, tumor necrosis factor alpha (TNF-alpha), and interferon-gamma (IFN-gamma) were measured using an enzyme-linked immunosorbent assay (ELISA) method. Results Serum neopterin (11.79 +/- 6.09), kynurenine (1655.48 +/- 1122.04), TNF-alpha (221.59 +/- 232.06) and IFN-gamma (137.68 +/- 107.11) levels were higher in the malignant group than in both the control (2.72 +/- 0.76, 352.40 +/- 69.33, 223.94 +/- 226.67, and 23.03 +/- 7.28, respectively) and benign groups (3.17 +/- 0.74, 377.94 +/- 109.05, 179.61 +/- 224.36, and 25.63 +/- 7.50, respectively) (p < 0.05). Another result of our study is that in the malignant group, serum neopterin levels exhibited significant positive correlations with serum kynurenine (r = 0.80, p < 0.0001), IFN-gamma (r = 0.86, p < 0.0001) and TNF-alpha levels (r = -0.27, p = 0.0453) and DII (r = 0.30, p = 0.0229), while they exhibited weak correlations with serum PSA, and other diet parameters. Additionally, kynurenine was the only parameter showing significant differences in mean values concerning surgical margins (p < 0.05). Conclusions The findings of this study support the hypothesis that serum neopterin and specific tryptophan catabolites (e.g., kynurenine), could serve as predictive and prognostic biomarkers for prostate cancer diagnosis. However, our results do not support the hypothesis that DII and certain dietary factors play a direct role in the development or diagnosis of prostate cancer.
AtıfScopus3WoS3OpenAlex2İncele - MakaleAçık Erişim2025Scopus SJRQ1Muay Thai exercises improve quality of life, love of life and self-control
Sahin, Oktay; Yilmaz, Coskun; Sezer, Sureyya Yonca; Sahin, Fatma Nese; Ceylan, Levent; Çelikel, Baha Engin; Tan, Cetin; Uçar, Mine Akkus; Kirikoglu, Nagihan
Background The existing research on Muay Thai sports has focused predominantly on the physiological effects of training, with limited attention devoted to the study of quality of life, love of life and self-control. The present study examined the effects of Muay Thai exercises on quality of life, love of life and self-control scores in healthy male subjects. Methods The present study comprised 50 healthy sedentary male subjects. The subjects were randomly divided into two groups: one group engaged in Muay Thai training (MTT), while the other group served as a control group (CON). The sample sizes for the MTT and CON groups were both 25. The MTT group participated in basic Muay Thai training, while the CON group continued their normal life regime. The SF-12 quality of life scale, love of life scale and multidimensional self-control scale were administered before and after the six-week training period. Results The study concluded that the six-week Muay Thai training program had a significant effect on quality of life levels, with 13.23% (p = 0.003) and 21.93% (p < 0.001) of participants demonstrating improvements in physical and mental scores, respectively. In terms of self-control levels, the program was found to have a significant effect on initiation and inhibition scores, with increases of 23.78% (p = 0.001) and 24.69% (p < 0.001), respectively. It was concluded that had a significant effect on the sub-dimensions of the Love of Life scale with increases of Positive Attitude Toward Life (PAWL) 18.63% (p < 0.001), Happy Results of the Love of Life (HRLL) 20.11% (p < 0.001) and Meaningfulness of Life (ML) 15.62% (p < 0.001), respectively. However, no significant differences were detected in any of the scales within the control group. Conclusion Muay Thai exercises had a positive effect on quality of life, love of life and self-control levels in healthy male subjects. By providing valuable insights into how Muay Thai exercise affects quality of life, love of life, and self-control, this research can guide future intervention and program design in the context of sport psychology.
AtıfScopus7WoS9OpenAlex8İncele - Derleme MakaleAçık Erişim2025Scopus SJRQ1Synergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review
Cherappurath, Nafih; Navaf, Muhammed; Ceylan, Halil Ibrahim; Elayaraja, Masilamani; Sunooj, Kappat Valiyapeediyekkal; Satheesan, Saranya T.; Thoompenthodi, Muhammed Ali; Perumbalath, Shamshadali; Bayrakdaroglu, Serdar; Muntean, Raul Ioan
Background/Objectives: Lifestyle-related diseases such as obesity, diabetes, hypertension, metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis disproportionately affect women due to hormonal, metabolic, and socio-cultural factors. Emerging evidence suggests that combining structured exercise with nano-curcumin, a bioavailable phytochemical formulation with potent antioxidant and anti-inflammatory properties, may provide synergistic benefits. This scoping review systematically synthesizes available evidence on the combined effects of nano-curcumin supplementation and exercise interventions on health outcomes in women with lifestyle-related diseases. Methods: Following the Joanna Briggs Institute methodology and the PRISMA-ScR framework, a comprehensive database search was conducted in March 2025 and updated in June 2025. Records were retrieved from Scopus (n = 30), Web of Science (n = 22), PubMed (n = 18), and other sources (n = 71), yielding a total of 141 studies. After screening and deduplication, eight studies met the inclusion criteria and were included in this review. All the studies were conducted in Iran with small sample sizes (12-53 participants) and short intervention durations (6-16 weeks). Therefore, the current evidence is geographically and demographically limited. Results: Across the included trials, the combined interventions produced additive or synergistic improvements in oxidative stress markers, inflammatory cytokines, lipid and glucose metabolism, cardiovascular function, pulmonary capacity, muscle fitness, and psychological outcomes (e.g., depression). When paired with nano-curcumin supplementation at different concentrations, high-intensity interval training, aerobic exercise, Pilates, and resistance training consistently outperformed exercise or supplementation alone in modulating antioxidant defenses, reducing systemic inflammation, and improving metabolic risk factors. Conclusions: The integration of exercise and nano-curcumin supplementation appears to confer superior benefits for women with lifestyle-related diseases compared with either approach alone. These findings highlight the potential of combining phytochemicals with lifestyle interventions to optimize women's health outcomes. However, most available evidence originates from small, short-term studies in single geographic regions. Large-scale, multicenter, randomized controlled trials with diverse populations are warranted to establish standardized protocols and optimal dosing strategies, and to assess long-term safety and efficacy.
AtıfScopus2WoS2OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ2Could GSTP1, PTEN and NKX3.1 gene expression be novel markers in the relationship between prostate cancer and epigenetics?
Koçak, Tevfik; Acar-Tek, Nilufer; Yesil, Suleyman; Ergün, Mehmet Ali; Icer, Yusuf
Background: Although numerous treatment modalities exist for Prostate Cancer (PCa) with a complex pathophysiology, a significant worldwide health concern for males, early identification remains the paramount factor influencing disease prognosis. Proposed new biomarkers, including GSTP1, PTEN, and NKX3.1, may provide predictive and prognostic functions, hence enhancing the efficacy of PSA in diagnosing prostate cancer. Epigenetic variables associated with nutrition influence the blood gene expression levels of the new biomarkers GSTP1, PTEN, and NKX3.1. This study aimed to elucidate the correlation between nutrition-related epigenetic variables and the expression of the tumor suppressor genes GSTP1, PTEN, and NKX3.1 in benign prostate and prostate cancer patients. Methods: This study was conducted with 41 newly diagnosed prostate cancer and 42 benign prostate patients, all aged 40 years and older. Participants had specific anthropometric measurements taken, and seven-day food records were kept. Serum levels of novel biochemical markers GSTP1, PTEN, and NKX3.1 were measured using an Enzyme-Linked Immunosorbent Assay (ELISA) method. Expression analyses of tumor-protective GSTP1, PTEN, and NKX3.1 genes were performed on prostate tissues obtained from fresh prostate biopsies taken from the groups and were associated with nutritional status. Results: A significant relationship was found between the serum levels of GSTP1, PTEN, and NKX3.1, which are important in the formation and treatment of prostate cancer, and Gleason grade, tumor stage, and surgical margin status (p < 0.05). However, significant relationships were found between many macro and micronutrients obtained from the dietary pattern and effective in epigenetic pathways and GSTP1, PTEN, and NKX3.1 gene expressions (p < 0.05). Conclusions: The findings of this investigation corroborated the notion that prospective novel markers, including GSTP1, PTEN, and NKX3.1, may serve predictive and prognostic functions in prostate cancer, hence enhancing the efficacy of PSA in its diagnosis. Dietary trends may influence the optimization of many epigenetic processes. Targeted therapeutic nutritional interventions designed to enhance gene expression will facilitate the formulation of prostate cancer prevention methods.
- MakaleAçık Erişim2025Scopus SJRQ1A Dose-Dependent Study Examining Dexmedetomidine's Possible Effects Against Oxidative, Fibrotic, and Apoptotic Damage Induced by Radiation Exposure in Spleen Tissue
Beyazal Polat, Hatice; Yilmaz, Hamit; Kilinc, Kagan; Gülhan, Belemir; Yilmaz Rakici, Sema; Tümkaya, Levent
Objective: This study aimed to investigate the potential splenic tissue damage induced by radiotherapy (RT) and the potential protective effect of different doses of dexmedetomidine on this damage at the histopathological, immunohistochemical, and biochemical levels. Materials and Methods: In our study, Sprague Dawley rats were randomly divided into four groups: Control, Radiotherapy (RT; 8 Gy), RT + Dexmedetomidine 100 mu g/kg (RT-D100), and RT + Dexmedetomidine 200 mu g/kg (RT-D200). A single dose of 8 Gy radiotherapy was administered to each RT group. Spleen tissues were examined histologically with hematoxylin-eosin and immunohistochemically with anti-Caspase-3, anti-TGF-beta 1, and anti-TGF-beta 3 using light microscopy. TBARS and total thiol levels were also analyzed to assess oxidative stress and antioxidant capacity. Results: Histopathological results showed a significant decrease in white pulp diameter, decreased cellular density, and increased congestion in the red pulp in the RT group. Significant fibrosis, sinusoidal dilatation, vacuolization, and amyloid deposition were detected in the white pulp in the RT group. Regarding anti-caspase-3 immunoreactivity, strong positivity increased in the red pulp in the RT group, while a significant increase was observed in the white pulp in both the RT-D100 and RT groups. While the proportion of TGF-beta 1 immunopositive cells did not change significantly in the RT group, they increased significantly in both dexmedetomidine groups (especially RT-D200). TGF-beta 3 expression increased significantly only in the RT-D100 group. In biochemical analyses, TBARS levels increased significantly in the RT-D100 group. Total thiol levels decreased in the RT group and increased in the dexmedetomidine-treated groups. Conclusions: While RT caused histopathological damage and increased oxidative stress in spleen tissue, dexmedetomidine reduced this damage in a dose-dependent manner. The different immunohistochemical profiles of TGF-beta 1 and TGF-beta 3 suggest that these cytokines may have different functions in the spleen. 100 mu g/kg dexmedetomidine stimulates a regenerative response through TGF-beta 3, while 200 mu g/kg dexmedetomidine may provide immune regulation and antioxidative defense through TGF-beta 1.
AtıfScopus3WoS3OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ1FinTech driven green energy transition foreign direct investment and ecological footprint in BRICST countries
Ayaydin, Hasan; Ergün, Tolga; Barut, Abdulkadir; Erdem, Azad; Pilatin, Abdulmuttalip
The increasing emphasis on climate change and environmental sustainability worldwide has brought about the convergence and increased focus on financial technologies (FinTech) and green energy initiatives. In light of this, the study's objective is to investigate how FinTech moderates the relationship between the ecological footprint (EF) and green energy transition (GTE) in the BRICS-T nations between 1990 and 2021. This study examines how fintech moderated the GTE and EF in the BRICS-T from 1990 to 2021. We applied the Fully Modified Ordinary Least Squares (FMOLS) and used Dynamic Ordinary Least Squares (DOLS) as the main estimators for longitudinal analysis. In contrast, Driscoll-Kraay was used to verify the robustness of the results under cross-sectional dependence and heteroskedasticity. The results reveal that FinTech indirectly hinders EF by facilitating GTE. The outcomes also show that FinTech significantly constrains EF, while GDP and industrialization worsen EF. The results also confirm the important role of GTE and foreign direct investment (FDI) in reducing CO2 emissions in BRICS-T countries. Lastly, the paper offers policymakers useful recommendations for lowering EF in light of these outcomes. The study suggests establishing appropriate policies and strategies that encourage FinTech platforms to invest in green energy projects, including financial technology, promoting energy-efficient and low-carbon foreign direct investment, and encouraging GTE.
AtıfScopus13WoS12OpenAlex12İncele - Derleme MakaleAçık Erişim2025Scopus SJRQ1Therapeutic Bioactivity Exerted by the Apis mellifera Bee Venom and Its Major Protein Melittin: A Scoping Review
Erdogan, Perihan Mutlu; Bilgili-Tetikoglu, Funda; Çelik-Uzuner, Selcen; Yildiz, Oktay; Kolayli, Sevgi; Mossialos, Dimitris
Honey bee (Apis mellifera) products have been extensively utilized in traditional medicine. Bee venom (BV) is one of the major bee products with a high concentration of the small peptide melittin (MEL) and exerts bioactivity ranging from anti-microbial to anti-inflammatory and anti-cancer. This scoping review aims to sum up research articles on the bioactivity exerted by BV and MEL published in PubMed and Scopus from 2010 onwards. PRISMA guidelines were implemented to analyze the relevant literature; we ended up with 425 research articles. Bioactivity of BV and MEL was grouped as (i) anti-inflammatory (85), (ii) immunomodulatory (37), (iii) anti-microbial (179), (iv) anti-cancer (170), and (v) anti-oxidant (32). Although there is a significant body of research on the anti-cancer and anti-microbial activity of BV and MEL, their anti-oxidant, anti-inflammatory and immunomodulatory properties have received comparatively less attention. Many studies on the immunomodulatory effects of BV or MEL have focused on cancer. However, the effects on Parkinson's and Alzheimer's disease have not been extensively studied regarding the anti-inflammatory effects. Given the critical role of the immune system and inflammatory response in cancer, neurodegenerative diseases, senescence and against infections, it is paramount to further explore the immunomodulatory and anti-inflammatory potential of BV and MEL.
AtıfScopus8WoS7OpenAlex8İncele - MakaleAçık Erişim2025Scopus SJRQ2Exploring the acute recovery effects of dry cupping therapy and electrical stimulation on anaerobic performance metrics in active individuals: A quasi-experimental crossover study
Can, Ibrahim; Yerlikaya, Gokhan; Yalçin, Seda; Bayrakdaroglu, Serdar; Kayhan, Recep Fatih; Uluç, Ender Ali; Stefanica, Valentina; Ceylan, Halil Ibrahim
Background:This quasi-experimental crossover study aimed to examine the acute effects of dry cupping therapy (DCT) and neuromuscular electrical stimulation (NMES) on fatigue and perceived exertion in anaerobic performance among physically active individuals.Methods:Twelve male participants (mean age: 24.1 +/- 2.37 years), all students from the Faculty of Sports Sciences, were recruited to participate voluntarily. Anaerobic performance parameters, including peak power, mean power (MP), and fatigue index (FI), were assessed using a Monark 839E cycling ergometer under 3 distinct conditions: NMES, DCT, and a control condition (no intervention), with each session separated by a 48-hour rest period. Perceived exertion was evaluated immediately following each test session using Borg's rate of perceived exertion (RPE) scale. Both NMES and DCT were administered bilaterally to the hamstring (m. hamstring) and quadriceps femoris (m. quadriceps femoris) muscles for 20 minutes before testing.Results:The results revealed no statistically significant differences in peak power and MP across the conditions. However, significant effects were identified for FI (F(2, 22) = 4.08, P = .031, eta p(2) = 0.27) and RPE (F(2, 22] = 8.88, P = .0015, eta p(2) = 0.45). Post hoc pairwise comparisons indicated that NMES significantly reduced FI compared to the control condition (P = .0311), with a small to medium effect size (Cohen's d = 0.44). In terms of RPE, DCT significantly lowered values compared to both the control (P = .0018) and NMES conditions (P = .0005), demonstrating medium (Cohen's d = 0.74) and small to medium (Cohen's d = 0.37) effect sizes, respectively.Conclusions:While NMES and DCT did not elicit acute improvements in peak or mean anaerobic power, both interventions effectively mitigated fatigue and reduced perceived exertion during maximal anaerobic exercise. These findings suggest that NMES and DCT may serve as valuable recovery modalities for mitigating fatigue in sports characterized by high anaerobic demands. Future research should investigate the chronic effects of these interventions and explore their utility among trained athletes to determine their broader applicability in enhancing athletic performance.
- MakaleAçık Erişim2024Scopus SJRQ1Isometric Shoulder and Hip Strength Impact on Throwing Velocity and Reactive Strength
Kayhan, Recep Fatih; Terzi, Esranur; Bayrakdaroglu, Serdar; Ceylan, Halil Ibrahim; Biyikli, Turker
The aim of the study is to examine relationships between shoulder extension-flexion and internal-external rotation strength of professional male handball players with throwing velocity, and the hip extension-flexion strength with horizontal and vertical reactive strength index. Fifteen professional male handball players participating in 1 st League matches took part in the study. The results showed that isometric shoulder flexion and extension strength significantly predicted stable throwing velocity (r (2 )=between 0.27-0.73) and dynamic throwing velocity (r( 2) =between 0.30-0.62). In addition, isometric internal and external rotation strength significantly predicted stable throwing velocity (r (2) =between 0.32-0.54) and dynamic throwing velocity (r (2) =between 0.31-0.44). Moreover, isometric hip extension and flexion strength significantly predicted vertical reactive strength index (r( 2) =between 0.31-0.45) and horizontal reactive strength index (r (2) =between 0.26-0.42). In conclusion, it was observed that shoulder strength has an enhancing effect on handball players' throwing velocity, while hip strength is a determining factor for the reactive strength index. In this context, it is assumed that shoulder weakness during throwing will affect the accuracy and velocity of throwing by disrupting the angular momentum, while weakness in the hip during the jump phase of the throwing motion will negatively affect the explosive power by limiting stabilization during landing.
AtıfWoS4OpenAlex6İncele - MakaleAçık Erişim2024Scopus SJRQ2The effect of motivational interviewing on quality of life and self-efficacy behaviors of individuals with chronic illness: A meta-analysis study
Uzun, Sevda; Guerhan, Nermin
ObjectiveThis study aims to reveal the effect of the motivational interviewing on the quality of life and self-efficacy behaviors of individuals with chronic diseases.Material-methodFor this meta-analysis study, PubMed, Web of Science, EBSCOhost, Google Scholar, and Y & Ouml;K Theses databases were searched in January-May 2021 without year limitation. As a result, 38 studies were included in the study: 23 for the quality of life variable, and 21 for the self-efficacy behaviors variable (in 6 studies, both variables were examined together). The data were synthesized with meta-analysis and narrative methods. The total sample size of the studies is 25,425.ResultsThis meta-analysis study showed that the motivational interviewing applied to individuals with chronic diseases changed their quality of life (SMD: 0.296, %95 CI: 0.054-0.537, Z = 2.402, p = .016, I2 = %95). The type of chronic disease, measurement tool, sample group, disease group, age range, and whether the motivational interviewer was a nurse or not changed the effect size of the motivational interviewing on the quality of life. The self-efficacy score average of the experimental group to which motivational interviewing was applied was statistically similar to that of the control group (SMD: 0.141, %95 CI: -0.065, 0.347; Z = 1.346, p = .178, I2 = %87).ConclusionsAs a result of the meta-analysis, it was determined that the use of motivational interviewing increased the quality of life level of individuals with chronic diseases. However, it is thought that more research is needed because some studies were conducted with small sample size and prepost test design. The results of the study may provide guidance on the interventions to be used in improving the quality of life of individuals with chronic diseases.
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