Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(15)
- Tuncer, Metin(8)
- Kulakaç, Nurşen(7)
- Topal, Meryem(5)
- Emirza, Elif Güzide(4)
- Topal, Fevzi(4)
- Tuncer, Gülsüm Zekiye(4)
- Balci, Neslihan(3)
- Yapıcı, İsmail(3)
- Öztürk Sarıkaya, Sevim Beyza(3)
- Ürkek, Bayram(3)
- Akdoğan, Arda(2)
- Akmeşe, Osman(2)
- Aktepe Coşar, Dilan(2)
- Aliyazicioglu, Yüksel(2)
- Altay, Ahmet(2)
- Arslan Burnaz, Nesibe(2)
- Aslan, Osman Nuri(2)
- Aydin Sayilan, Aylin(2)
- Aydın, Kemal(2)
- Balcı, Neslihan(2)
- Baltacı, Cemalettin(2)
- Bayrak, Nurten Gülsüm(2)
- Bursal, Ercan(2)
- Büyük, Ersin(2)
- Demir Çam, Sevgi(2)
- Demir, Selim(2)
- Demirağ, Hatice(2)
- Ediz, Çiçek(2)
- Gulcin, Ilhami(2)
- Gültekin, Ergün(2)
- Gülçin, İlhami(2)
- Kalay, Erbay(2)
- Khorshtd, Leyla(2)
- Köksal, Ekrem(2)
- Sünnetçi, Kadir(2)
- Turan, İbrahim(2)
- Turan, Şeyma(2)
- Ulutaşdemir, Nilgün(2)
- Zehiroğlu, Cuma(2)
Yayınlar
- MakaleYalnız künye2021Scopus SJRQ2In vitro Antioxidant and Cytotoxic Activities of Extracts of Endemic Tanacetum erzincanense Together with Phenolic Content by LC-ESI-QTOF-MS
Yapıcı, İsmail; Altay, Ahmet; Öztürk Sarıkaya, Beyza; Korkmaz, Mustafa; Atila, Alptuğ; Gülçin, İlhami; Köksal, Ekrem
In this study, phenolic composition, and in vitro biological activities of ethyl acetate (EAE) and methanol (ME) extracts obtained from the aerial parts of endemic Tanacetum erzincanense were investigated. Total phenolic and flavonoid content of the extracts were determined by Folin-Ciocalteu and aluminum chloride colorimetric methods, respectively. Antioxidant capacity of the extracts was evaluated over radical scavenging (DPPH and ABTS) and metal ion reducing power (FRAP and CUPRAC) tests. Individual phenolic compounds in ME was analyzed by high-performance liquid chromatography coupled to electrospray ionization quadrupole time-of-flight mass spectrometry (LC-ESI-QTOF/MS). Cell inhibitory potential of the extracts was tested against colorectal adenocarcinoma (HT-29), breast adenocarcinoma (MCF-7), and hepatocarcinoma (HepG2) cells by 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay. The results showed that ME contains higher TPC (64.4 mg GAE/g) and TFC (62.2 mg QE/g) than those of EAE (41.5 mg GAE/g and 40.0 mg QE/g). LC-ESI-QTOF/MS analysis revealed that ME is rich in phenolic compounds, namely, chlorogenic acid, apigenin, quercetin, luteolin, and diosmetin. Antioxidant assay results indicated that ME possess stronger activity than EAE and a power that competes with synthetic antioxidants. XTT assay results demonstrated that although both extracts displayed a considerable cytotoxicity against the tested cancer cell lines in a time and dose-dependent manner, ME expressed its selective inhibitory action towards MCF-7 cells with an IC50 value of 20.4 μg/mL for 72 h. These results may serve as a basis for further in vivo studies to examine the potential applications of T. erzincanense in food and pharmaceutical industries.
- MakaleYalnız künye2021Scopus SJRQ1Mineral content, fatty acid composition, and volatile compounds of gluten-free tarhana formulated with different cereal and pulse flours
Çalışkan Koç, Gülşah; Tekgül, Yeliz; Erten, Edibe Seda; Akdoğan, Arda
Abstract: This research was intended to determine the effect of different cereal and pulse flours and commercial gluten-free flour on the mineral content, fatty acid composition, and volatile compounds of the gluten-free tarhana (cereal-based fermented dry soup). In order to produce the gluten-free tarhana, white bean (BF), chickpea (CF), commercial gluten-free (GWF), yellow lentil (LF), and rice (RF) flours were used. The Mg, K, Al, and Mn contents of tarhanas obtained using different pulse and cereal flours were found to be quite high compared to tarhanas produced with commercial GWF. The utilization of different cereal and pulse flours in the tarhana formulation resulted in an increase in the percentage (30.37–51.47%) of the total polyunsaturated fatty acid (TPUFA). The highest (452.4 µg/g) and the lowest (241.17 µg/g) total concentration of all compounds were detected in BF and GWF, respectively. The highest number (21) of compounds belonged to terpenes and terpenoids, followed by acids, hydrocarbons, alcohols, aldehydes, esters, ketones, and alkanes. Practical Application: This study shows that cereal and pulse flours can be used to produce acceptable tarhana with improved nutritional quality in terms of mineral and fatty acid contents. The results of the current study may be useful and applicable to food manufacturers producing gluten-free products for celiac patients.
- MakaleYalnız künye2021Scopus SJRQ2On the absolute stable difference scheme for the space-wise dependent source identification problem for elliptic-telegraph equation
Ashyralyev, Allaberen; Al-Hammouri, Ahmad; Ashyralyyev, Charyyar
The present paper is devoted to study the first order of accuracy absolute stable difference scheme for the approximate solution of the space identification problem for the elliptic-telegraph equation in Hilbert spaces with the self-adjoint positive definite operator. The main theorem on the stability of the difference scheme is established. In applications, theorems on the stability of difference schemes for two types of the space identification problems for multidimensional elliptic-telegraph partial differential equations are proved. Numerical analysis is provided.
- MakaleYayıncıda açık erişim2021Scopus SJRQ1Factors affecting nurses' professional commitment during the COVID-19 pandemic: A cross-sectional study
Duran, Secil; Celik, Isa; Ertugrul, Bekir; Ok, Serife; Albayrak, Sevil
Aim: This study aims to investigate the factors affecting nurses' professional commitment during the COVID-19 pandemic. Background: Commitment to a profession requires doing the best for that profession. In the case of the nursing profession, professional commitment gains greater importance in times of crisis, like the COVID-19 pandemic. Methods: This cross-sectional study was conducted with 389 nurses in the Turkish state hospital. Institutional permissions, ethical approval and written consents from the participants were obtained before carrying out the study. Results: The participants’ mean Perceived Organizational Obstruction Scale score was 20.07 ± 8.06 (min = 5.0, max = 35.0), and their mean Nursing Professional Commitment Scale score was 71.20 ± 11.94 (min = 30.0, max = 103.0). Socio-demographic variables and perception of organisational obstruction predicted 36.7% of the variance in the professional commitment (p <.001). Conclusion: A road map based on the study results was developed for hospitals and nurse managers to maintain and increase nurses' professional commitment. Implications for Nursing Management: The results of this study may help institutions and nurse managers understand the factors affecting professional commitment during the pandemic as a whole, as well as determine primary strategies based on the importance of these factors.
- MakaleAçık Erişim2021Scopus SJRQ2Constrained adaptive backstepping control of a semi-active suspension considering suspension travel limits
Yıldız, Ali Suat; Sivrioğlu, Selim
In this article, a new constrained adaptive backstepping control design is presented for vibration suppression of the quarter car suspension system equipped with a magnetorheological (MR) damper. In the controller design, parametric uncertainties related to suspension parameter and the semi-active actuator are considered. Also, the proposed controller is investigated, along with the designed road profiles based on the International Standard Organization (ISO) 8608 classification and tested under different speed conditions. The effectiveness of the proposed controller has been validated through comparisons with uncontrolled, passive, and separately designed adaptive control cases. According to the simulation and experimental results, the proposed control approach improves ride comfort and ride safety without violating suspension rattle space constraint despite the uncertainties in suspension parameters.
- MakaleYalnız künye2021Scopus SJRQ2Inhibition Profiles of Some Symmetric Sulfamides Derived from Phenethylamines on Human Carbonic Anhydrase I, and II Isoenzymes
Topal, Fevzi; Aksu, Kadir; Gulcin, Ilhami; Tümer, Ferhan; Goksu, Süleyman
In this work, the inhibitory effect of some symmetric sulfamides derived from phenethylamines were determined against human carbonic anhydrase (hCA) I, and II isoenzymes, and compared with standard compound acetazolamide. IC50 values were obtained from the Enzyme activity (%)-[Symmetric sulfamides] graphs. Also, Ki values were calculated from the Lineweaver-Burk graphs. Some symmetric sulfamides compounds (11–18) demonstrated excellent inhibition effects against hCA I, and II isoenzymes. These compounds demonstrated effective inhibitory profiles with IC50 values in ranging from 21.66–28.88 nM against hCA I, 14.44–30.13 nM against hCA II. Among these compounds, the best Ki value for hCA I (Ki: 8.34±1.60 nM) and hCA II (Ki: 16.40±1.00 nM) is compound number 11. Besides, the IC50 value of acetazolamide used as a standard was determined as hCA I, hCA II 57.75 nM, 49.50 nM, respectively. Moreover, in silico ADME-Tox study showed that all synthesized compounds (11–18) had good oral bioavailability in light of Jorgensen's rule of three, and of Lipinski's rule of five.
- MakaleAçık Erişim2021Scopus SJRQ2The effect of COVID-19 anxiety levels of healthcare professionals on the quality of working life and related factors
Aydın, Aykut; Kulakaç, Nurşen; Aydın Sayılan, Aylin
Aim: This study aims to determine the effect of COVID-19 anxiety levels of healthcare professionals on their working life quality. Method: The sample of the descriptive, cross-sectional and correlational study consisted of healthcare professionals working in two university hospitals in western Turkey between May and July 2021. We used the “Personal Information Form, Coronavirus Anxiety Scale, and Working Life Quality Scale” as data collection tools. We used numbers and percentage calculations, arithmetic mean, median (25th–75th percentile), Mann–Whitney U test, Spearmen correlation analysis and Linear Regression analysis to analyse the data. Results: The mean score on the Quality of Life Scale of healthcare professionals was 3.74 ± 0.28, and the mean score on the Coronavirus Anxiety Scale (CAS) was 9.66 ± 6.06 (min. 0; max. 20). We found a negative and weakly significant relationship between the mean score of the CAS of healthcare professionals and the mean score of the employee quality of life scale. According to the results of the multiple linear regression analysis, we found the factors significantly affecting the anxiety states of healthcare professionals related to the Coronavirus are the quality of working life, age, sex and the state of caring for a patient with COVID-19. Conclusion: As a conclusion of this study, it was determined that healthcare professionals experienced anxiety, and anxiety decreased as ages, working years and the number of children they have increased. In addition, it was determined that as the anxiety of healthcare professionals increased, the quality of working life decreased.
- MakaleYalnız künye2021Scopus SJRQ3Determination of Angelica archangelica’s Antioxidant Capacity and Mineral Content
Topal, Meryem; Ozturk Sarıkaya, S. Beyza; Topal, Fevzi
The aim of this study was to determine the mineral contents by ICP-MS and the antioxidant capacity of Angelica archangelica plant, which is not well known in the literature. For this purpose, ethyl alcohol extracts of the branches and leaves of the plant; different bioanalytical methods such as reducing capacity by Fe3+−Fe2+ transformation method, Fe3+-TPTZ reducing capacity by FRAP method, Cu2+-Cu+ reducing capacity by CUPRAC method, the ferric ions (Fe2+) chelating activity by using bipyridyl reagent, DPPH (1,1-diphenyl-2-picryl-hydrazyl) free radical, DMPD (N,N-dimethyl-p-phenylenediamine), ABTS (2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical scavenging activities, total antioxidant activity determination according to thiocyanate method, total phenolic and total flavonoid activity were used. As standard, BHT, BHA, α-Tocopherol, Trolox were used. A. archangelica branches and leaves demonstrated 88.13 % and 93.90 % inhibition of linoleic acid emulsion peroxidation at 20 mg mL−1 concentration. Also, it was determined that both leaves and branches of A. archangelica plant were dense with P, Mg, Ca and K minerals with ICP-MS device. It is considered that the results of the manuscript will guide the antioxidant studies, medicine, cosmetics, pharmacology and food sector.
- MakaleAçık Erişim2021Scopus SJRQ2Burnout levels and sleep quality of COVID-19 heroes
Aydin Sayilan, Aylin; Kulakaç, Nurşen; Uzun, Sevda
Purpose: This study was carried out to determine the burnout levels and sleep quality of nurses in the coronavirus disease-2019 process. Design and Methods: The population of this descriptive and cross-sectional study consisted of all nurses working in hospitals in Turkey. Findings: Nurses' mean scores were compared by gender. The emotional burnout and personal achievement scores of male nurses were higher than those of female nurses. Single nurses had significantly higher emotional exhaustion and depersonalization scores than married individuals. Nurses mostly experienced emotional exhaustion, and burnout levels increased in line with insomnia. Implications for Nursing Practice: Nurses struggling on the frontline during the pandemic were determined to be at risk of insomnia and burnout.
- MakaleAçık Erişim2021Scopus SJRQ2The relationship between anxiety levels and anger expression styles of nurses during COVID-19 pandemic
Bayrak, Nurten Gülsüm; Uzun, Sevda; Kulakaç, Nurşen
Objective: This study was carried out in a cross-sectional and correlational design to explore the relationship between anxiety levels and anger expression styles of nurses during the COVID-19 pandemic. Methods: The sample of this cross-sectional and correlational type of study consisted of 618 nurses calculated with the snowball sampling method. The data were collected using a questionnaire developed by the researchers, the state anxiety inventory, and the trait anger and anger expression scale and was conducted between May 10 and 20, 2020 using an online questionnaire form. Percentage, mean, standard deviation, the Mann–Whitney U test, Kruskal–Wallis test, Spearman correlation analysis, and multiple linear regression analysis were used to evaluate the data. Results: The mean age of nurses was 34.98 ± 8.36 years (min: 20; max: 53), 87.4% were women, and 81.7% experienced a high level of anxiety. The anger scores of the participants were found to be 20.04 ± 4.43, the anger-in score was 15.55 ± 3.34, the anger-out score was 14.01 ± 2.87, and the anger control score was 22.93 ± 3.6. Being married, the presence of chronic disease, living in the Marmara region, working shifts, presence of an individual over 65 years of age at home, and having a COVID-19 test were found to be risk factors that significantly increase nurses' anxieties. A significant positive relationship was found between the anxiety scores, trait anger (r = 0.249, p = 0.000), anger-in (r = 0.174, p = 0.000) and anger-out (r = 0.205, p = 0.000) scores of nurses, and a significant negative relationship was found between the anxiety scores and anger control (r = 0.249, p = 0.000) score. Conclusion: The study revealed that in the COVID-19 pandemic the anxiety levels of the nurses were high and that the high anxiety level negatively affected the style of anger expression, but the nurses were successful in maintaining anger control. In line with these results, it is important that nurses develop effective coping strategies to reduce their anxiety levels and that they receive increased levels of support in managing anger expression.
- MakaleYalnız künye2015Scopus SJRQ2Equilibrium, kinetics, and thermodynamic evaluation of mercury (II) removal from aqueous solutions by moss (Homalothecium sericeum) biomass
Ozdes, Duygu; Duran, Celal
In the present research, Homalothecium Sericeum was utilized for the first time as an effective and readily available adsorbent in removal of Hg(II) ions from aqueous solutions through a batch adsorption technique. The effects of initial solution pH, contact time, initial Hg(II) and adsorbent concentration, temperature, and ionic strengths were evaluated on the removal efficiency of Hg(II) ions, after being characterized of H. sericeum by different techniques. The maximum Hg(II) adsorption was obtained as 128.2 mg g-1 at initial pH 6.0 with an equilibrium time of 60 min, adsorbent dosage of 5.0 g L-1 and initial Hg(II) concentration range of 50-750 mg L-1. The adsorption behaviors of Hg(II) ions onto H. sericeum were investigated in terms of kinetics (pseudo-first order, pseudo-second order, and intraparticle diffusion models), isotherms (Langmuir, Freundlich, and Dubinin Radushkevich models), and thermodynamics evaluation. Both the Langmuir and Freundlich isotherm models were found to be suitable to describe the adsorption equilibrium while the adsorption kinetics followed by the pseudo-second order model. Thermodynamic parameters including the Gibbs free energy (ΔG), enthalpy (ΔH), and entropy (ΔS) changes indicated that the adsorption of Hg(II) ions onto H. sericeum was feasible, spontaneous, and endothermic in nature.
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