Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(64)
- Merdan, Mehmet(47)
- Baltaci, Cemalettin(35)
- Kulakaç, Nurşen(28)
- Duran, Celal(27)
- Ozdes, Duygu(24)
- Turan, Ibrahim(24)
- Demir, Selim(23)
- Türkkan, Tuğba(22)
- Bayrakdaroglu, Serdar(21)
- Topal, Fevzi(21)
- Öztürk, Serkan(21)
- Ürkek, Bayram(21)
- Gücer, Mehmet Ali(20)
- Akar, Zeynep(19)
- Kaygusuz, Abdullah(19)
- Topal, Meryem(19)
- Anaç, Halil(18)
- Aydin, Aydanur(18)
- Batan, Nevzat(18)
- Erata, Hüseyin(18)
- Tuncer, Metin(18)
- Akyürek, Suat(17)
- Baltacı, Cemalettin(17)
- Karimullah, Suud Sarim(17)
- Acet, Tuba(16)
- Akar, Bülent(16)
- Ashyralyyev, Charyyar(16)
- Düzgün, Azer Özad(16)
- Hintistan, Sevilay(16)
- Yılmaz, Coşkun(16)
- Aliyazicioglu, Yuksel(15)
- Kaya, Hacer(15)
- Kurnaz, Muammer(15)
- Kurt, Kemal(15)
- Ozden, Talat(15)
- Yilmaz, Coskun(15)
- Yuksel, Ferhat(15)
- Yücel, Cem(15)
- Öz, Mehmet(15)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ1Match success in football: insights from raw and possession-normalized key performance indicators in the Turkish professional league
Sever, Ozan; Öncü, Çağdaş; Öztaşyonar, Yunus; Aksoy, Ömer; Bayrakdaroğlu, Serdar
Background: Match-performance indicators are widely used to explain success in football; however, traditional analyses based solely on absolute key performance indicators (KPIs) may overlook contextual factors such as ball possession and phase of play. This study aimed to examine match-performance indicators associated with winning in Turkish professional football using two complementary approaches: a raw KPI model based on absolute match actions and a possession- and phase-of-play–normalized KPI model accounting for contextual opportunity. Methodology: Match data were obtained from a validated event-based database covering six consecutive seasons, yielding 2,728 team observations from 1,364 win–loss matches. Descriptive comparisons between winning and losing teams were conducted, followed by multivariate binary logistic regression analyses to identify performance indicators independently associated with match success under both modeling approaches. Results: At the descriptive level, winning teams demonstrated higher values for shots, shots on target, accurate passes, opponent-half accurate passes, accurate crosses (%), and opponent-half accurate passes (%), whereas total possession and total passes did not differ significantly between groups. In terms of disciplinary indicators, losing teams received significantly more yellow and red cards, whereas fouls committed were significantly higher in winning teams (p = 0.014). However, the normalized indicator (fouls committed per out-of-possession) did not differ significantly between groups. In the raw KPI model, positive predictors of match success included shots on target (OR = 1.58), accurate crosses (OR = 1.10), opponent-half accurate passes (OR = 1.01), and fouls committed (OR = 1.04). Negative predictors were total crosses (OR = 0.92), yellow cards (OR = 0.89), and red cards (OR = 0.49). In the possession-normalized model, significant positive predictors were shots on target per possession, accurate crosses per possession, and fouls committed per out-of-possession. Significant negative predictors included crosses per possession, accurate crosses (%), yellow cards per out-of-possession, and red cards per out-of-possession. Conclusions: The findings indicate that combining absolute performance indicators with context-sensitive normalized metrics may provide a more comprehensive perspective on match success in football. Offensive efficiency and disciplinary control emerged as key correlates of winning, particularly when evaluated relative to possession and phase-of-play contexts. These findings suggest the potential value of integrating contextualized performance analysis into match evaluation and performance analysis frameworks.
AtıfWoS1OpenAlex1
İncele - MakaleAçık Erişim2026Scopus SJRQ2Computational prioritization of multi-target inhibitors: explainable QSAR and docking-based discovery of dual AChE/BACE1 chemotypes
Bozkır, İsa; İbişoğlu, Merve Seda; Kayıkçıoğlu Bozkır, İlknur; Güler, Halil İbrahim
The discovery of dual acetylcholinesterase (AChE) and β-secretase (BACE1) inhibitors remains a promising strategy against multifactorial Alzheimer’s disease. Here, rigorously curated ChEMBL-derived data were used to develop explainable QSAR (Quantitative structure–activity relationship) models for dual-inhibition prioritization. Molecules were standardized, near-duplicates were removed using a Tanimoto similarity threshold (≥ 0.80), and physicochemical outliers were filtered prior to modeling. Multiple classifiers (including Light Gradient-Boosting Machine, eXtreme Gradient Boosting, Random Forest, Support Vector Machine, k-Nearest Neighbors and Gradient Boosting Decision Trees) and fingerprints (e.g., RDKit fingerprints, Extended Connectivity Fingerprint) were benchmarked under scaffold-based nested cross-validation to prevent data leakage. Class imbalance was handled with SMOTETomek applied strictly within training folds. Model selection relied on F-Score, Area Under the Precision–Recall Curve, Matthews Correlation Coefficient (MCC), and Recall, and performance was accompanied by bootstrap confidence intervals, calibration curves, and Y-randomization controls. In classification, the top model (GBDT + ECFP6) achieved strong generalization (Recall ≈ 1.00, PR-AUC ≈ 0.84, MCC ≈ 0.81, F1 Score ≈ 0.84). Shapley Additive Explanations (SHAP) analysis highlighted aromatic and hydrogen-bonding substructures as key positive contributors. Prospective candidates (e.g., CHEMBL5082250, CHEMBL1651126, CHEMBL1651127) were evaluated by active-site-focused docking against AChE (PDB: 4EY7) and BACE1 (PDB: 2G94) with essential waters retained; docking scores (ΔG, kcal·mol⁻1) were used for relative ranking of the ligands. SwissADME/pkCSM profiling suggested CNS-relevant properties (e.g., MPO, logBB, P-gp liability) and acceptable oral drug-likeness. Collectively, the workflow provides a reproducible and transparent pipeline for prioritizing dual AChE/BACE1 chemotypes and nominates testable scaffolds for experimental validation.
AtıfScopus2WoS2OpenAlex5İncele - MakaleAçık Erişim2026Scopus SJRQ1Process Intensification Sonocatalytic Degradation of Malachite Green Wastewater over Hydrothermally Engineered M-ZLT@Co3O4 Nanocatalyst: Structure–Activity Relationships, Radical-Mediated Mechanism and Degradation Pathways
Kıranşan, Murat
This study reports the sonocatalytic degradation of malachite green (MG) in media using synthesized Co3O4 nanoparticles and a CTAB-modified zeolite supported Co3O4 hybrid nanocatalyst (M-ZLT@Co3O4). The catalysts were characterized by XRD, FT-IR, SEM-EDX, TEM, XRF, N2 adsorption–desorption, BET, and BJH analyses, verifying crystalline Co3O4 formation, successful immobilization on the modified zeolite support, porous architecture, morphology and elemental distribution. Under optimized conditions of 1 g L−1 catalyst dosage, 20 mg L−1 MG concentration, natural pH, and 300 W L−1 ultrasonic power, M-ZLT@Co3O4 achieved 99.31% ± 0.45% degradation within 120 min. Decreasing the MG concentration to 5 mg L−1 increased the efficiency to 99.96% ± 0.64%, confirming high activity at low pollutant loading. The degradation followed pseudo-first-order kinetics, with kapp values of 0.0042–0.0595 min−1 depending on catalyst dosage, 0.0046–0.0667 min−1 for initial MG concentration, and 0.0117–0.0620 min−1 under pH conditions. Water matrix inhibition followed distilled water (99.31%) > tap water (96.08%) > river water (88.84%) > lake water (86.90%), whereas higher ultrasonic power increased degradation from 91.98% at 200 W L−1 to 99.90% at 500 W L−1. Dye degradation followed MG (99.31%) > CR (95.78%) > BY2 (92.15%) > MV (90.24%) > AO7 (85.62%) > RB19 (82.49%). Comparative tests demonstrated performance for US/M-ZLT@Co3O4 (99.31%) compared with US/Co3O4 nanoparticles (78.48%), US/ZLT (72.86%), and US/MG alone (35.71%). The best activity was obtained at 0.8–2 g L−1 catalyst dosage and 5–20 mg L−1 MG concentration, while reusability tests showed a decrease from 99.31% to 78.82% after six cycles, indicating promising stability.
- MakaleAçık Erişim2026Scopus SJRQ1Turkish Adaptation, Psychometric Validity and Measurement Invariance of the Reasons for Implicit Rationing of the Nursing Care Scale
Özalp, Cemal; Gerçek, Abdullah; Tuncer, Metin
Aim: This study aimed to adapt the Reasons for Implicit Rationing of Nursing Care Scale into Turkish and evaluate its validity, reliability and measurement invariance among nurses in Türkiye. Background: Implicit rationing of nursing care may compromise care quality and patient safety and is influenced by organizational, resource-related and communication factors. A culturally valid instrument is needed to identify the factors contributing to implicit rationing of nursing care within the Turkish healthcare context. Design: A methodological, cross-sectional psychometric validation study. Method: Data were collected between July and December 2025 from nurses working in a public hospital in Türkiye. The source population comprised 900 nurses and 411 nurses were included in the final sample using convenience sampling. Data were collected using the Personal Information Form and the Reasons for Implicit Rationing of Nursing Care Scale. Construct validity was examined using exploratory and confirmatory factor analyses on randomly divided samples. Convergent and discriminant validity and gender-based measurement invariance were assessed. Reliability was evaluated using Cronbach's alpha, McDonald's omega and the intraclass correlation coefficient. Results: The Kaiser–Meyer–Olkin value was 0.936, indicating that the data were suitable for factor analysis. Exploratory factor analysis revealed a two-factor structure consistent with the original scale, explaining 74.30% of the total variance. Confirmatory factor analysis demonstrated acceptable model fit. Convergent validity was supported, whereas the heterotrait–monotrait ratio value indicated borderline discriminant validity. Measurement invariance across genders was largely supported at the configural, metric and scalar levels. The scale demonstrated high internal consistency and temporal stability, with a Cronbach's alpha value of 0.941, a McDonald's omega value of 0.932 and an intraclass correlation coefficient value of 0.873. Conclusion: The Turkish version of the Reasons for Implicit Rationing of Nursing Care Scale is a valid, reliable and gender-invariant instrument. It can be confidently used in Turkish clinical settings to assess factors contributing to implicit rationing of nursing care.
- MakaleAçık Erişim2026Scopus SJRQ4Identification of Problems Faced by Individuals with Epilepsy in Health Communication
Bingöl, Nuray; Aktepe Coşar, Dilan; İşcan Ayyıldız, Neşe
Objective: Individuals with epilepsy often face challenges with medication adherence and health monitoring because communication difficulties that hinder self-expression and information exchange, thereby complicating effective disease management. This study aimed to examine the health communication problems experienced by individuals with epilepsy. Methods: This descriptive, cross-sectional study was conducted among 172 individuals with epilepsy who presented to the neurology outpatient clinic in eastern and northern Türkiye between August 2023 and August 2024. Study data were collected using the descriptive data form and the health communication problems scale. The independent groups t-test, one-way ANOVA, and Tukey test were used to evaluate the data. Results: On the health communication problems scale, individuals with epilepsy had mean scores of 2.41 ± 0.53 for the effective communication problems sub-dimension, 2.88 ± 0.80 for the social communication problems sub-dimension, and 2.68 ± 0.72 for the communication barriers sub-dimension. No significant differences were detected in the mean scores for health communication problems among individuals with epilepsy by sex, health expenditure, seizure type, or seizure characteristics (p > 0.05). Conclusion: The study revealed that individuals with epilepsy experienced moderate difficulty with health communication. Those who were married, had higher educational attainment, were unemployed, had lower income levels, and were receiving polytherapy experienced greater communication challenges with healthcare professionals.
- MakaleAçık Erişim2026Scopus SJRQ1Psychosocial dimension of adolescent pregnancy: a phenomenological study on life experiences
Ediz, Çiçek; Uzun, Sevda
Aim: This study aimed to assess the lived experiences of adolescent pregnant young women, with a specific focus on the psychosocial aspect of adolescent pregnancy, using a phenomenological approach. Design: Employing the phenomenological research method, semi-structured in-depth interviews were conducted between 3 August and 18 August 2023 with 15 young women (mean age = 21.86 years; SD = 1.06) living in a province in eastern Turkey who had undergone adolescent pregnancy 3–5 years before. Methods: The criterion sampling method, a form of purposive sampling, was used to form the sample group. Interviews were carried out until data saturation was reached. All interviews were recorded and transcribed, and thematic analysis was utilised to analyse the data. The study adhered to the COREQ checklist for reporting. Results: Through data analysis, three main categories (reflections on adolescent pregnancy, challenges due to adolescent pregnancy, and effects of adolescent pregnancy) and nine sub-themes (emotions, roles and responsibilities, perception of social support, cognitive, emotional, behavioural, mental, physical, and social) emerged. Conclusion: Our study highlights the adverse psychosocial impact of adolescent pregnancy on young women. Young women who got married at an early age before attaining full physical, social, and psychological maturity grappled with the substantial burdens of adolescent pregnancy and adjusting to their new roles. The study’s implications are significant, emphasising the necessity of addressing the psychosocial facets of adolescent marriage and pregnancy, and gaining valuable insights for the future.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2026Scopus SJRQ2A novel decision-making approach based on regret theory under bipolar Z-number information
Altun, Fatma; Köseoğlu, Ali; Şahin, Rıdvan
This study introduces a new set theory called bipolar fuzzy Z-number set that makes it possible to express an information both bipolar from positive and negative perspectives, and with the reliability of it. Then, besides basic set-theoretical operations and the score function, a new distance measure is also presented. Furthermore, a decision method integrating with regret theory is proposed. Additionally, to compute the weights of criteria under bipolar Z-number information, a method in which objective and subjective criterion weights are considered simultaneously is introduced by combining the weights found by SWARA and MEREC. Also, a model with standard deviation is developed to obtain decision maker’s weights. Finally, the problem of selection of paper raw material is handled to demonstrate stability and advantage of the proposed method.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ1Weight self-stigma, weight bias internalization, and eating attitudes in relation to body appreciation
Koçak, Tevfik; Kocyigit, Emine; Demirel Ozbek, Yagmur; Celik, İsa
Objective: This study aimed to investigate the relationships between weight self-stigma, weight bias internalization, eating attitudes, and body appreciation in young adults, and to ascertain the distinct impact of these variables on body appreciation. Methods: A cross-sectional study was carried out including young adults aged 19 to 35 years, comprising 69.6% females and 30.4% males. Participants completed a questionnaire evaluating weight self-stigma, internalization of weight bias, eating attitudes, and body appreciation. Hierarchical multiple regression analyses were used to assess the additional impacts of weight-related stigma and eating attitudes on body appreciation, while adjusting for demographic and anthropometric factors. Results: Weight self-stigma, particularly the internalization of weight bias, showed a significant negative association with body appreciation. Weight self-stigma and its subdimensions (self-devaluation and fear of enacted stigma) had substantial negative correlations with body appreciation. These correlations encompassed the subdimensions of body appreciation, specifically general body appreciation and body image investment. While eating attitudes did not show a significant correlation with body appreciation at the bivariate level, they became a significant predictor in the hierarchical regression model, suggesting a conditional (suppression) effect after accounting for weight-related stigma and BMI. Conclusion: The findings emphasize the important function of weight-related stigma in diminishing body appreciation among young adults and stress the necessity of examining eating attitudes in conjunction with stigma-related factors. Interventions designed to enhance positive body image should focus on both internalized weight stigma and maladaptive eating-related attitudes.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ4Understanding Loyalty in the Aviation Sector: The Mediating Role of Perceived Value between Brand Equity and Loyalty
Okan, Serdar
This research examines the mediating role of perceived value in the relationship between brand equity and passenger loyalty, focusing on Turkish Airlines. Data were gathered from 569 passengers of Turkish Airlines and were analyzed by using EFA in SPSS and CFA in SmartPLS. The results indicate that brand equity significantly has an indirect impact on passenger loyalty (β = 0.112, P = 0.011). In addition, although brand equity has a positive effect on perceived value (β = 0.240, P < 0.001), perceived value also has a positive effect on loyalty (β = 0.493, P < 0.001). The results also indicate that perceived value partially mediates the effect of brand equity on loyalty (β = 0.118, P < 0.001). Such findings imply that post-flight communication with the company, passengers’ feedback opportunities and efficient service problem resolution might result in an increase of perceived value fostering customer loyalty. There appears to be a significant underestimation of the importance of the direct effect and of its impact on the indirect effects of brand equity. This study bridges the research gap by analyzing perceived value as a mediator between brand equity and loyalty, focusing on Turkish Airlines.
- MakaleAçık Erişim2026Scopus SJRQ2A Non-Newtonian Extension of Laplace–Sumudu–Elzaki Transforms
Yalcin, Numan
Classical Laplace-, Sumudu-, and Elzaki-type transforms are formulated within additive analytical frameworks and do not naturally accommodate multiplicative scaling structures arising in non-Newtonian calculus. Motivated by this limitation, this study introduces a non-Newtonian Laplace–Sumudu–Elzaki transform (NNLSET) based on logarithmic scaling mechanisms, multiplicative measures, and power-type kernels. The proposed framework is constructed by replacing the classical measure dt with the multiplicative measure (Formula presented.) and the linear scaling structure (Formula presented.) with the nonlinear scaling structure (Formula presented.). Using the logarithmic transformation (Formula presented.), a canonical kernel representation of the form (Formula presented.) is derived, establishing a correspondence between multiplicative power-type kernels and weighted exponential structures in the logarithmic domain. Within an admissible weighted function framework, several analytical properties of the transform are established, including existence, boundedness, stability, uniqueness, restricted recoverability, and a logarithmic derivative representation associated with expressions of the form (Formula presented.). A comparative analysis with the classical Laplace–Sumudu–Elzaki framework, together with illustrative differential-equation examples, a representative nonlinear MEMS oscillator, and a numerical computation, is presented. The obtained results demonstrate that the NNLSET provides a mathematically consistent framework for the analysis of multiplicative structures, logarithmic scaling phenomena, and logarithmically structured differential equations. Its applicability is further illustrated through the analysis of a representative nonlinear MEMS oscillator.
- MakaleAçık Erişim2026Scopus SJRQ1Citizen-Science Data Reveal Global Diversity Patterns in the Gecko Genus Hemidactylus
Kurnaz, Muammer; Berber, Ahmet Ali; Akbulut, Cansu
Understanding how species richness is distributed across space is a central goal of macroecology and biogeography. The gecko genus Hemidactylus ranks among the most speciose and broadly distributed of all squamate genera, with species spanning tropical and subtropical environments on most continents. Yet the large-scale structure of its diversity has rarely been examined at a global scale. Here we assembled georeferenced occurrence data for the genus from the Global Biodiversity Information Facility (GBIF Access data is 14 March 2026) and, following cleaning and quality control, retained 143,858 records covering 157 currently recognized species (approximately 79% of the genus) to characterize broad-scale biodiversity patterns. Our analyses addressed the latitudinal diversity gradient, the distribution of species range sizes, continental richness, spatial clustering of diversity, and regional beta diversity. Richness declined steadily from the tropics toward the poles, producing a pronounced latitudinal diversity gradient (Pearson r = −0.71, p < 0.001). A generalized additive model captured a strong non-linear association between latitude and richness (deviance explained = 98.1%), consistent with tropical regions acting as principal centers of diversity. Range-size distributions were markedly right-skewed, with the majority of species restricted to comparatively small areas; however, these estimates co-varied strongly with per-species sampling effort (r = 0.90) and warrant cautious interpretation. We found only a weak, marginally significant association between range size and latitudinal midpoint, offering little support for Rapoport’s rule in the genus. At the continental scale, Hemidactylus diversity was overwhelmingly concentrated in Afro-Asian tropical regions (Asia, 93 species; Africa, 66), whereas Europe and Oceania supported few species (four each). Spatial analyses indicated significant autocorrelation in richness (Moran’s I = 0.56, p < 0.001) and well-defined diversity hotspots in East Africa, the Indian subcontinent, and Southeast Asia, and regional beta diversity was high (Jaccard dissimilarity up to 0.97), reflecting pronounced faunal turnover among continents.
- MakaleAçık Erişim2026Scopus SJRQ1Valorization of pomegranate peel waste through pyrolysis-liquid-assisted ultrasound extraction: antioxidant, antibacterial and targeted phytochemical characterization
Gül, Abdulkadir; Aydoğmuş, Ercan; Özgen, İnanç; Yılmaz, Fırat; Deniz, Sermin; Arslanoğlu, Hasan
Background: Pomegranate (Punica granatum L.) peel is a phenolic-rich processing by-product, but its valorization commonly relies on conventional solvents. This study examined an integrated approach in which pomegranate peel pyrolysis liquid (PP-PL) was repurposed as the extraction medium for ultrasound-assisted extraction (UAE) of the same biomass. The methodological originality lies specifically in using biomass-derived PP-PL in UAE. Results: PP-PL-assisted extract (PP-E) and an aqueous control extract (AQ-E), prepared from the same peel batch under identical UAE conditions, were compared. The apparent gravimetric recovery of PP-E was 202.5 g kg−1. PP-E showed approximately two-fold higher total phenolic and flavonoid contents than AQ-E. In vitro agar well diffusion screening revealed the largest inhibition zone for PP-E against Staphylococcus aureus at 80 g L−1 (22.65 ± 1.50 mm), whereas AQ-E produced no detectable inhibition zones against the tested strains at the same concentration. PP-E achieved DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS+ (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) radical-scavenging values of 92.42 ± 0.25% and 97.00 ± 0.17%, respectively, and showed pronounced total antioxidant capacity and iron(III) ion (Fe3+)- and copper(II) ion (Cu2+)-reducing capacities. Targeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) using authentic standards quantified six phenolics, with ellagic acid as the predominant analyte (2015.10 mg kg−1 extract). Conclusion: Integration of pomegranate peel pyrolysis with PP-PL-assisted UAE generated an extract exhibiting in vitro antioxidant properties and antibacterial potential in agar well diffusion screening, providing an alternative route for pomegranate peel valorization. This strategy supports the further development of biomass-derived extraction media for recovering value-added compounds from agro-industrial residues.
- MakaleAçık Erişim2026Scopus SJRQ2Carbon footprint assessment and reduction strategies of a university campus in Turkey
Türle, İbrahim; Celen, Pınar
As key institutions and significant energy consumers, universities have a critical responsibility to lead efforts in energy efficiency and renewable energy use to reduce their environmental impact. In this regard, the Gümüşhane University carbon probe has produced the first study that makes it possible to identify the sources of greenhouse gas emissions and provides the opportunity to track, measure, and suggest reduction strategies in the years to come. The carbon footprint of Gümüşhane University from 2017 to 2023 has been calculated and examined in this paper. The IPCC and DEFRA conversion factors served as the foundation for the computations. The results showed that the university's use of natural gas and electricity was responsible for almost all of its carbon emissions. According to the IPCC and DEFRA, the 2017 emissions were 4999.93 and 4667 tCO2e, respectively. Following a move to online instruction in 2020, emissions decreased to 3894 tCO2e under DEFRA and 4365.44 tCO2e under IPCC. However, as campus life resumed its pre-pandemic pace in 2022 and 2023, emissions rose again, surpassing 5252.04 tonnes of CO₂e by 2023 using the IPCC method and 4042 tonnes of CO₂e using the DEFRA method. These results suggest that universities need to focus on their energy consumption patterns in order to reduce their carbon emissions, for example by placing greater emphasis on renewable energy sources, energy efficiency, and balanced consumption. The outcomes of this research will act as a guideline not only for Gümüşhane University to help it reach its sustainability goals, but also for other university administrations when formulating effective carbon reduction strategies, and for institutions seeking to measure or benchmark their environmental performance.
- MakaleAçık Erişim2026Scopus SJRQ3Chemical Profiling of Essential Oils and Evaluation of Enzyme Inhibition, Antioxidant, and Antimicrobial Activities in Both Methanol Extract and Essential Oils of Centaurea oltensis
Aygül, İmdat; Akşit, Berfin
The phytochemical composition and biological activities of Centaurea oltensis, an endemic species in Türkiye, were studied. GC–MS/FID analysis identified 128 compounds representing 99.2% of the EO, with decanoic acid (15.1%), α-pinene (7.9%), and sabinyl acetate (5.4%) as the principal constituents. GC–MS/FID analysis identified 128 compounds representing 99.2% of the essential oil (EO), with decanoic acid (15.1%), α-pinene (7.9%), and sabinyl acetate (5.4%) as the principal constituents. LC–MS/MS analysis of the methanol extract (ME) revealed high concentrations of ferulic acid (2410 µg/g dw) and chlorogenic acid (1170 µg/g dw), together with caffeic, salicylic, and 4-hydroxybenzoic acids. The ME exhibited potent carbonic anhydrase-II inhibition (IC₅₀ = 0.028 µg/mL) and significant α-glucosidase inhibition (IC₅₀ = 0.255 mg/mL). The EO showed strong acetylcholinesterase and butyrylcholinesterase inhibitory activities, with IC₅₀ values of 0.0145 µg/mL and 0.204 µg/mL, respectively. Antioxidant assays, including DPPH, ABTS, and FRAP, demonstrated superior activity of the ME, correlating with its higher phenolic and flavonoid contents. The EO displayed remarkable antibacterial activity against Staphylococcus aureus (MIC = 0.02 mg/mL) and moderate antifungal activity against Candida albicans. Overall, C. oltensis demonstrated considerable chemical diversity and promising antioxidant, antimicrobial, neuroprotective, and enzyme inhibitory potential for future pharmacological and therapeutic applications.
- MakaleAçık Erişim2026Scopus SJRQ3Institutional Determinants of Regional Poverty in Turkey: Evidence from Advanced Causality Analysis
Çiçen, Yıldırım Beyazıt
Poverty continues to be one of the major issues in Turkey, as in many other countries, with a large portion of the population – especially in rural areas – living below the poverty line. Those living in poverty have limited access to key public services such as education, healthcare and housing, which consequently exacerbates social and economic inequalities within society. The gap between wealthy and impoverished groups within society is continually expanding, primarily due to institutional factors that perpetuate this inequality. Drawing on data from 2009 to 2019, this study offers an empirical analysis of the role of institutions in shaping poverty in Turkey. The study applies the panel causality test developed by Juodis et al. (2021) to assess the influence of institutional structures on regional disparities. Infant mortality rates, the number of associate and bachelor’s degree graduates and the number of convicts are considered key indicators of institutional performance. The statistical analysis reveals a significant correlation between these variables and the 50% poverty rate. The findings suggest that strengthening the institutional framework is essential for addressing regional poverty in Turkey.
AtıfOpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ2Enhanced Computational Efficiency in Solving Delay Fractional Partial Differential Equations Through the Yang Decomposition Method
Ali, Mustafa Ahmed; Merdan, Mehmet
This study presents the Yang Transform Adomian Decomposition Method (YTADM), a semi-analytical framework for solving one-dimensional linear and nonlinear delay fractional partial differential equations involving the Caputo fractional derivative. The proposed method combines the Yang transform with the Adomian decomposition method to construct recursive solution series while efficiently handling delayed nonlinear terms. The applicability of the proposed framework is demonstrated through several examples, including proportional-delay Burgers-type equations, and its convergence properties are analyzed. The obtained results show that YTADM yields rapidly convergent semi-analytical approximations and provides an effective framework for solving one-dimensional delay fractional partial differential equations.
- MakaleAçık Erişim2026Scopus SJRQ2Fully automated 3D volumetric analysis of masticatory muscles in a pediatric population: A CT-based normative morphometric study
Kanber Uzun, Özlem; Ertemoğlu Öksüz, Canan; Kalkışım, Şahi Nur; Palancı, Özgür; Yıldırım, Yusuf İslam
The masticatory muscles play a fundamental role in craniofacial growth and development, yet normative volumetric data encompassing all four muscles across the full pediatric age range remain poorly characterized. The aim of this study was to establish age- and sex-specific normative reference values for the volumetric development of masticatory muscles in a normal pediatric population (0–17 years) using a fully automated 3D segmentation method. This retrospective, cross-sectional study included 258 normal pediatric individuals stratified into four age groups based on biomechanical milestones (0–5, 6–9, 10–13, and 14–17 years). Bilateral volumes of the masticatory muscles were automatically calculated using TotalSegmentator in the 3D Slicer environment. Two-way analysis of variance and Bonferroni post-hoc tests were applied. All muscles showed significant volume increases with age (p < 0.001), with the masseter demonstrating the greatest increase (199%). No sex differences were observed in 0–5 years; significant male-favoring differentiation began from 6 to 9 years. The temporalis muscle exhibited a biphasic sex differentiation pattern, with no significant difference at 10–13 years despite significance at 6–9 and 14–17 years. The highest sex-related effect sizes were observed in the pterygoid muscles (medial pterygoid ηp² = 0.176; lateral pterygoid ηp² = 0.160). Bilateral asymmetry analyses revealed left-sided favoring in the masseter, a lateralization trend in the temporalis (exploratory), right-sided favoring in the medial pterygoid, and sex-specific lateralization in the lateral pterygoid. These findings provide a large-scale CT-based normative reference for pediatric masticatory muscles, demonstrating muscle-specific volumetric patterns and variable sex differentiation, with normative ranges supporting clinical decision-making in dentistry, craniofacial surgery, and pediatric radiology.
- MakaleAçık Erişim2026Scopus SJRQ1Comparative Mechanical and Thermal Performance of Graphene- and Silver Nanoparticle-Reinforced PLA Fabricated by FDM 3D Printing
Karabudak, Filiz
The increasing demand for high-performance and multifunctional polymer materials has driven interest in improving the mechanical properties of polymer components produced through additive manufacturing. This study aims to systematically investigate and comparatively evaluate the effects of low-content nanofiller incorporation on the structural, thermal, and mechanical performance of PLA-based materials produced via fused deposition modeling (FDM), with a focus on identifying filler-dependent behavior under different loading conditions. In this study, polylactic acid (PLA) composites reinforced with 0.5 wt.% graphene (Gr) and 0.5 wt.% silver (Ag) nanoparticles, added separately, were produced using fused deposition modeling (FDM) and comparatively investigated. Each nanofiller was incorporated individually into PLA-based filaments, and standard test specimens were fabricated via 3D printing. Structural, thermal, and mechanical properties were evaluated using tensile, compressive, and three-point bending tests, along with SEM, EDS, XRD, FTIR, DSC, and TGA analyses. The results showed that pure PLA exhibited typical brittle behavior and a single-stage thermal degradation profile. The tensile strength of pure PLA was 41.93 MPa, and the flexural strength was 70.76 MPa. The addition of 0.5 wt.% graphene led to noticeable improvements, particularly in flexural properties, while only a minimal (almost negligible) increase was observed in tensile strength, with tensile strength increasing to 42.24 MPa (+0.74%) and flexural strength increasing to 110.78 MPa (+56.6%). In contrast, 0.5 wt.% Ag exhibited mixed and load-dependent mechanical behavior, with slight improvements in flexural strength but reductions in tensile and compressive properties, where tensile strength decreased to 22.13 MPa (−47.2%) while flexural strength increased to 112.06 MPa (+58.3%). Structural and thermal analyses indicated that both nanofillers did not significantly alter the PLA matrix chemically, while contributing to controlled changes in material properties primarily through physical interactions. The novelty of this work lies in the comparative evaluation of graphene and silver nanoparticle reinforcement at a fixed low loading level within FDM-processed PLA, combined with a comprehensive and correlated analysis of mechanical, structural, and thermal behavior on the same specimen sets, enabling a clearer understanding of filler-dependent performance mechanisms in additively manufactured nanocomposites. Overall, it was concluded that low-rate nanofiller additions, when properly dispersed, may lead to selective improvements in the performance of PLA-based composites depending on filler type and loading mode, and show potential for advanced engineering applications such as lightweight structural components, functional sensors, and additive-manufactured parts requiring tailored mechanical performance and multifunctionality.
- MakaleAçık Erişim2026Scopus SJRQ1Cortical thickness and volume alterations in patients with high myopia: a magnetic resonance imaging study
Aydin, Emre; Palanci, Ozgur
Background: The retina and optic nerve are integral components of the visual system and maintain direct anatomical and functional connections with the brain. Both structures are markedly affected in high myopia (HM). Accordingly, characterizing brain structural alterations associated with HM may provide important insights into its underlying neurobiological mechanisms. Using brain magnetic resonance imaging (MRI), this study aimed to evaluate regional gray matter (GM) and white matter (WM) volume changes, their relative percentages, and cortical thickness alterations in individuals with HM. Methods: High-resolution structural MRI, together with visual acuity (VA), intraocular pressure (IOP), refractive error, axial length (AL), and anterior chamber depth (ACD), was used to compare 30 adults with HM and 22 healthy controls (HC). Regional brain volumes and cortical thickness were analyzed in the fusiform gyrus (FuG), inferior temporal gyrus (ITG), middle temporal gyrus (MTG), superior temporal gyrus (STG), and occipital subregions including the calcarine cortex (Calc), cuneus (Cun), lingual gyrus (LiG), inferior occipital gyrus (IOG), middle occipital gyrus (MOG), and superior occipital gyrus (SOG). Results: Compared with HCs, HM patients demonstrated significant volumetric increases in the ITG and MTG regions (all p < 0.05), with the left ITG remaining significant after false discovery rate (FDR) correction. No significant volumetric differences were observed in the fusiform or occipital regions. In contrast, cortical thickness analyses revealed significant thinning in the fusiform gyrus and bilateral occipital subregions, including the calcarine cortex, cuneus, lingual gyrus, and middle occipital gyrus (p = 0.000–0.026, FDR-corrected). Cortical thickness in the fusiform and occipital regions showed negative correlations with AL and ACD and positive correlations with spherical equivalent. Conclusions: High myopia is associated with region-specific brain structural alterations, characterized by volumetric increases in temporal regions and cortical thinning in fusiform and occipital areas, indicating that HM-related neuroanatomical changes extend beyond the ocular system to involve central nervous system structures. Trial registration: Not applicable.
AtıfScopus1WoS1İncele - MakaleAçık Erişim2026Scopus SJRQ3Chemical Profiling and Biological Activities of Methanol Extracts and Essential Oils From Ferulago Platycarpa Boiss. & Balansa (Endemic): Enzyme Inhibition, Antioxidant, and Antimicrobial Properties
Aygül, İmdat; Öz, Mehmet; Fidan, Muhammed Said; Baltacı, Cemalettin; Akmeşe, Osman; Sefalı, Abdurrahman
This study aimed to evaluate the phytochemical composition and biological activities of Ferulago platycarpa methanol extract (ME) and essential oil (EO). The EO was obtained via hydrodistillation and analyzed by GC-MS, revealing sesquiterpene hydrocarbons as the dominant class, with caryophyllene (65.8%) and α-pinene (9.65%) as the major constituents. The methanol extract was subjected to LC-MS/MS analysis, which identified eleven phenolic compounds, with chlorogenic acid as the most abundant. The extract showed significantly higher total phenolic (1196.22±11.64 mg GAE/100g) and antioxidant (1870.00±17.69 mg QEE/100g) contents compared to the ME. In vitro enzyme inhibition assays demonstrated that the methanol extract exhibited potent inhibitory activity against carbonic anhydrase II (CA-II, ICSO= 0.023 pg/mL), acetylcholinesterase (AChE, ICSO= 110 pg/mL), and butyrylcholinesterase (BChE, IC50= 390 pg/mL). In contrast, the EO showed higher inhibition against α-amylase (IC50= 5920±10.45 pg/mL) and BChE (IC50= 1.32±0.65 pg/mL), while its α-glucosidase showed no inhibition. Antioxidant assays indicated superior activity for the methanol extract compared to the EO. Furthermore, antimicrobial testing revealed that the EO demonstrated broader and more effective antimicrobial action, exhibiting lower MIC and MBC values against several bacterial and fungal strains. Collectively, these results highlight F. platycarpa as a valuable source of bioactive compounds with promising applications in antidiabetic, neuroprotective, antioxidant, and antimicrobial therapies.
