Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(64)
- Merdan, Mehmet(47)
- Baltaci, Cemalettin(35)
- Kulakaç, Nurşen(28)
- Duran, Celal(27)
- Ozdes, Duygu(24)
- Turan, Ibrahim(24)
- Demir, Selim(23)
- Türkkan, Tuğba(22)
- Bayrakdaroglu, Serdar(21)
- Topal, Fevzi(21)
- Öztürk, Serkan(21)
- Ürkek, Bayram(21)
- Gücer, Mehmet Ali(20)
- Akar, Zeynep(19)
- Kaygusuz, Abdullah(19)
- Topal, Meryem(19)
- Anaç, Halil(18)
- Aydin, Aydanur(18)
- Batan, Nevzat(18)
- Erata, Hüseyin(18)
- Tuncer, Metin(18)
- Akyürek, Suat(17)
- Baltacı, Cemalettin(17)
- Karimullah, Suud Sarim(17)
- Acet, Tuba(16)
- Akar, Bülent(16)
- Ashyralyyev, Charyyar(16)
- Düzgün, Azer Özad(16)
- Hintistan, Sevilay(16)
- Yılmaz, Coşkun(16)
- Aliyazicioglu, Yuksel(15)
- Kaya, Hacer(15)
- Kurnaz, Muammer(15)
- Kurt, Kemal(15)
- Ozden, Talat(15)
- Yilmaz, Coskun(15)
- Yuksel, Ferhat(15)
- Yücel, Cem(15)
- Öz, Mehmet(15)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ2Experimental and Modeling Study of Fluidity in Ductile Iron (GGG40)
Coşar, Mehmet; Şüküroğlu, Ebru Emine; Güngör, Kadir; Çolak, Murat
Ductile irons (spheroidal graphite cast irons, SGI) are widely used in automotive and energy systems due to their high strength, ductility, and excellent machinability. The casting quality of these alloys largely depends on the flow and filling behavior of the molten metal, namely its fluidity. In this study, the effects of pouring temperature, filling time, and metallurgical quality on the fluidity of GGG40 ductile iron were investigated through both experimental and numerical approaches. Experimental trials were conducted at pouring temperatures of 1350 °C, 1400 °C, and 1450 °C; metallurgical quality levels of 10%, 50%, and 90%; and filling times of 5 s and 10 s. The fluidity lengths were measured and statistically evaluated. The results revealed that increasing the pouring temperature and metallurgical quality significantly improved fluidity, while shorter filling times allowed the molten metal to travel longer distances before solidification. Modeling studies performed using a commercial casting simulation software showed strong correlation with the experimental data. Microstructural examinations indicated that higher pouring temperatures and improved metallurgical quality led to a more homogeneous distribution of graphite nodules and an increased ferrite fraction in the matrix. The findings provide valuable insights into the influence of process parameters on the fluidity behavior of ductile iron and offer critical design data for enhancing casting quality and productivity in industrial foundry applications.
AtıfScopus1
İncele - MakaleAçık Erişim2026Scopus SJRQ3The Effect of Teamwork Attitudes on Job Performance: A Study Among Nurses; [Ekip Performansı Tutumunun İş Performansına Etkisi: Hemşireler Örnekleminde Bir Araştırma]
Köse, Aslı
Aim: To evaluate the impact of nurses’ teamwork attitudes on their job performance. Method: A descriptive, correlational quantitative research design was employed. The sample consisted of 350 nurses who worked at a city hospital in Turkey and voluntarily participated. Data were analyzed using SPSS 25 to assess differences in teamwork attitudes and job performance according to nurses’ educational levels and years of professional experience. Results: The analysis revealed no statistically significant differences in teamwork attitudes or job performance based on educational level. The mean total score for teamwork attitudes was (3.27±0.80), while the mean total score for job performance was 3.25 (SD=0.82). A strong positive correlation was found between teamwork attitudes and job performance (r = 0.764; p < 0.001). A strong positive correlation was found between teamwork attitudes and job performance, with the former accounting for 58.4% of the variance in the latter. Conclusion: This study found that nurses working in a city hospital exhibited moderate attitudes toward teamwork and moderate job performance, and that these two measures were strongly positively correlated.
- MakaleAçık Erişim2026Scopus SJRQ2Motion-Robust Optical Granulometry for Comminution Circuits: A Multi-Stream Temporal Deep Learning Framework
Hasozdemir, Kursat; Meral, Mert; Kahraman, Muhammet Mustafa
Accurate near-real-time granulometry is critical for optimizing energy efficiency in comminution circuits, yet standard optical monitoring systems fail under the harsh conditions of industrial mining. High conveyor velocities induce motion blur, while heavy dust loads occlude particle boundaries, leading to severe under-counting of fine fractions and an overestimation of product coarseness. This paper proposes a novel tracking framework to overcome these limitations. The method integrates a five-frame temporal rolling buffer with a multi-stream augmentation architecture that decouples motion and texture features. Experimental validation on the feed of a secondary conical crusher at an operational facility demonstrates that the proposed framework recovers significant particle data lost by baseline models, correcting the measured D80 and D50 values of the crushed material. This correction reveals a finer true load, enabling more precise closed-loop control of crusher settings and reducing unnecessary energy consumption.
- MakaleAçık Erişim2026Scopus SJRQ3Greenwashing in Wood Substitute Products: The Case of PVC Window Frames
Top, Yener
Wood is a renewable material, and advancements in machinery have made it possible to produce wood-based products in large quantities. This has led to environmental problems, which in turn have increased consumers’ environmental concern. This concern has caused consumers to prefer environmental-friendly products. Alongside green products and green marketing, greenwashing practices, which are not actually green but exploit consumer sensitivity, have also become widespread. These deceptive claims confuse consumers and provide an unfair competitive advantage against genuinely environmentally friendly products. Polyvinyl chloride (PVC) windows, which can be used as a substitute for wood windows, were chosen as a research focus, and the greenwashing practices of enterprises manufacturing PVC window were investigated. The research was conducted using deductive content analysis. The corporate websites of the enterprises were examined in terms of greenwashing. Artificial intelligence was used, but identified greenwashing types were checked by the researcher. The study found that PVC window manufacturers most frequently resorted to greenwashing involving no proof, vagueness, and hidden trade-off approaches. Greenwashing types were also examined by topics, revealing that “general environmental benefits” is the most common type.
- MakaleAçık Erişim2026Scopus SJRQ1Detrital zircon ages, Lu-Hf isotopes of zircon grains, Sr-Nd isotopes on whole rock and geochemistry of Campanian turbidites in the Eastern Pontides (NE Türkiye): A provenance assessment and Gondwana records
Eker, Çiğdem Saydam; Yücel, Cem; Kaygusuz, Abdullah; Aydınçakır, Emre; Jeong, Youn-Joong; Yılmazer, Sinan; Sünnetçi, Kadir
Detrital zircons are crucial stand-ins for the history of continental crust growth and disintegration, as well as the dispersal and assembly of supercontinents. Detrital zircons are effectively used to assess crustal history because sediments transport zircons from source rocks that are no longer at the surface. This study presents detailed Lu-Hf isotopic, U-Pb geochronological analyses of zircon, Sr-Nd isotopic analyses and whole-rock geochemical results from sandstone, volcanically derived sandstone and tuff samples of the Campanian-aged Bozbent Member in the Eastern Pontide Orogen belt of the Sakarya Zone. Sedimentological analyses show that the Bozbent Member was transported and deposited by turbidite currents, while petrographic and geochemical analyses show that the sandstones range from greywacke to litharenite. In this study, U-Pb ages of detrital zircon obtained from Campanian sandstones are presented, along with in situ εHf data. A magmatic origin is indicated by the majority of zircons' oscillatory zoning and by Th/U ratios ranging from 0.2 to 1.5. The ages of detrital zircons range from 2819 to 78 Ma, with most of these zircons being Proterozoic (552–994 Ma). Proterozoic zircons are detrital zircons associated with the Gondwana and the African Craton. The whole-rock geochemical data and Sr-Nd isotope compositions of the sandstones are consistent with local Carboniferous felsic plutons, Jurassic mafic and felsic plutons, Jurassic volcanic rocks, Jurassic clastic rocks and clastic material from Precambrian recycled sediments. It was calculated that more than 90% of the detrital zircons had crystallisation ages older than their depositional ages (CA-DA > 150 Ma, indicative of an extensional basin model). These findings indicate that the Campanian-aged Bozbent Member turbiditic sequence in the Eastern Pontides was deposited in an extensional fore-arc basin and therefore exhibits the petrographic and geochemical characteristics of passive margin sandstones.
- MakaleAçık Erişim2026Scopus SJRQ3Investigation of the enzyme-inhibitory, antibacterial, and anticancer properties of metal phthalocyanines
Topal, Meryem; Topal, Fevzi; Yilmaz, Fırat; Bulut Atalay, Esra; Koçyiğit, Ümit Muhammet; Güzel, Emre
In this study, the enzyme inhibitory, antibacterial, and anticancer activities of a phthalonitrile derivative and its metal phthalocyanines (Pcs; indium, zinc, copper, cobalt, and manganese; 1–6) were investigated. The cobalt and manganese Pcs were synthesized for the first time in this study. The inhibitory activities of the symmetric Pcs, which were expected to interact with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) via their 4-(isopropylbenzyl)oxy substituents through host–guest interactions, were investigated. More selective inhibition of AChE than BChE was observed for these compounds. For AChE, CoPc was identified as the most potent inhibitor (IC50 = 14.81 nM), whereas for BChE, InPc was identified as the most potent inhibitor (IC50 = 56.35 nM). The Ki values indicated that most compounds exhibited competitive inhibition; copper phthalocyanine (CuPc) showed particularly strong inhibition against AChE (Ki = 3.08 nM ± 1.12), whereas the lowest Ki value against BChE was observed for MnPc (Ki = 25.98 ± 1.97 nM). Most compounds exhibited competitive inhibition; however, CuPc showed competitive inhibition toward AChE but a noncompetitive inhibition pattern toward BChE. Dual inhibition of AChE and BChE by these compounds may be promising for addressing cholinergic deficits associated with Alzheimer’s disease. In addition, the acceptability of compounds 1–6 with respect to pharmacological drug-likeness criteria was assessed based on predicted absorption, distribution, metabolism, excretion (ADME) outcomes. In antibacterial tests, varying levels of inhibition were observed against selected bacterial strains. In anticancer assays, all compounds exhibited high cytotoxicity against the MCF-7 breast cancer cell line. Higher antiproliferative activity was observed for CuPc than for the other compounds. Morphological changes were induced in cancer cells by CuPc and MnPc. Overall, these compounds may have potential as enzyme inhibitors and as antibacterial and anticancer agents.
AtıfScopus2WoS2OpenAlex2
İncele - MakaleAçık Erişim2026Scopus SJRQ2Evaluation of antioxidant and antiproliferative activities of shogaol and its modulatory effects on key metabolic enzymes
Yapıcı, İsmail; Gülçin, İlhami
Phenolic compounds are versatile bioactive molecules, particularly in food applications. In this study, the antioxidant capacity of Shogaol, a member of the phenolic class, was evaluated using several methods. Additionally, its inhibitory effects on human carbonic anhydrase I and II (hCA I and II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glycosidase, and α-amylase enzymes, as well as its antiproliferative effects on A-549 lung cancer, HT-29 colon cancer, MCF-7 and MDA-MB-453 breast cancer cell lines, and the 3T3-L1 mouse fibroblast normal cell line, were investigated. To determine the antioxidant capacity of Shogaol, DPPH and ABTS radical scavenging assays, as well as Cu²⁺, Fe³⁺, and FRAP reduction methods, were employed. Its inhibitory effects on hCA I and II, AChE, BChE, α-glycosidase, and α-amylase enzymes were examined. Furthermore, cell counting was performed using the TBE method, and cell viability was measured with the XTT assay to assess the antiproliferative effects of Shogaol on A-549, HT-29, MCF-7, MDA-MB-453, and 3T3-L1 cell lines. Shogaol demonstrated higher antioxidant capacity than BHA, BHT, and Trolox in the FRAP assay (60 µg/mL), higher than BHT in the DPPH scavenging assay, and higher than Trolox in the ABTS, Cu²⁺, and Fe³⁺ reduction assays. Shogaol also exhibited significant inhibitory effects against hCA I, hCA II, AChE, BChE, and α-glycosidase, with IC₅₀ values of 75.91, 47.04, 37.44, 24.11, and 35.72 nM, respectively. Moreover, Shogaol showed a more potent antiproliferative effect than the standard chemotherapeutic drug Carboplatin in A-549 lung cancer and HT-29 colon cancer cell lines, and greater efficacy than Docetaxel in the MCF-7 breast cancer cell line.
AtıfOpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ3Preferences for mechanical ventilation modes among intensivists in Türkiye: a nationwide point-prevalence study
Yildirim, Suleyman; Kilinçözgün, Nurhayat; Alpdogan, Ozcan; Uçar, Huseyin; Taskiran, Imren; Ata, Adnan; Özcan, Ozhan; Öncü, Kivanc; Acarbay, Saba Mukaddes; Güner, Temel
Background/aim: Invasive mechanical ventilation (IMV) is a fundamental intervention for patients with respiratory failure in intensive care units (ICUs). This nationwide, multicenter point-prevalence study aimed to describe current mechanical ventilation mode preferences (conventional, adaptive, and biphasic) in Turkish ICUs and to report associated clinical outcomes descriptively, without assessing causal relationships. Materials and methods: A nationwide, multicenter point-prevalence study was conducted on 17 April 2024 and included adult patients (>= 18 years) who had been receiving IMV for more than 24 h. Data on patient demographics, ventilation mode distribution, ventilatory parameters, and descriptive clinical outcomes on day 28 (weaning status, tracheostomy, and mortality) were recorded without comparative outcome analysis. Results: A total of 426 patients were included. Conventional modes were used in 84.5% of patients, adaptive modes in 10.6%, and biphasic modes in 4.9%. Synchronized intermittent mandatory ventilation (SIMV) was the most commonly used conventional mode. The primary indication for IMV was acute respiratory failure (61%), with pneumonia being the leading cause. Among the 350 orotracheally intubated patients, 25.6% were in the weaning phase on the study day. A total of 59 (16.9%) patients were extubated, 150 (42.9%) underwent tracheostomy, and 64 (18.2%) remained intubated on day 28. Overall, 185 (43.4%) patients died during their ICU stay, 152 (35.7%) remained in the ICU, and 89 (20.9%) were successfully discharged from the ICU. Conclusion: Conventional ventilation modes, particularly SIMV, were more commonly used in Turkish intensive care units (ICUs), whereas adaptive modes were less frequently applied. These patterns may reflect factors such as clinician familiarity, institutional practices, and equipment availability rather than definitive preferences. Although the impact of ventilation modes on clinical outcomes was not comparatively evaluated in this study, the choice of ventilation mode may still influence patient outcomes. Therefore, further prospective and comparative studies are warranted to better elucidate this relationship.
- MakaleAçık Erişim2026Scopus SJRQ1Ethical Principles and Frameworks in Dementia Care: A Scoping Review
Serrat, Rodrigo; Lauridsen, Sigurd; Bobrowicz-Campos, Elzbieta; Brandao, Tania; Brites, Rute; Cannella, Valentina; Celdrán, Montserrat; Chacur-Kiss, Karima; Cin, Aynur; Fabà, Josep
Providing ethical care for people living with dementia is essential for safeguarding their rights, dignity, and well-being. However, ethical decision-making in dementia care is complex, often involving tensions between competing moral claims such as autonomy, beneficence, nonmaleficence, justice, and non-discrimination. This scoping review aimed to map and describe the ethical principles, related normative considerations, and ethical frameworks discussed in the scientific literature on dementia care, and to identify how these have been conceptualized. Following the methodological guidance of Arksey and O'Malley (2005), Levac et al. (2010), and Peters et al. (2021, 2022), a comprehensive search across five databases (Web of Science, Scopus, CINAHL, Medline/PubMed, and PsycInfo) identified peer-reviewed papers published in English. In total, 388 papers published between 1981 and 2024 were included. The results revealed a wide range of ethical principles and related normative considerations frequently cited in the literature, although they were typically discussed in an isolated way without reference to other principles or broader ethical frameworks. In contrast, ethical frameworks were mentioned far less often, and when they were, they mostly reflected traditional approaches such as principlism. Four gaps were identified: the plurality of ethical frameworks and limited conceptual integration underpinning dementia care research and practice; insufficient attention to ethnic and socioeconomic diversity among people living with dementia; limited consideration of diverse care settings and geographical regions; and the limited inclusion of people living with dementia themselves in the studies reviewed. These findings underscore the need for conceptually integrative, inclusive, and context-sensitive approaches to dementia care ethics that can better inform both ethical reflection and care practices.
AtıfWoS1İncele - DüzeltmeAçık Erişim2026Scopus SJRQ1Ethical Principles and Frameworks in Dementia Care: A Scoping Review (vol 19, 29, 2026)
Serrat, Rodrigo; Lauridsen, Sigurd; Bobrowicz-Campos, Elzbieta; Brandao, Tania; Brites, Rute; Cannella, Valentina; Celdrán, Montserrat; Chacur-Kiss, Karima; Cin, Aynur; Faba, Josep
Unfortunately, this article was published online with errors—the blinded names were not replaced. The corrected sentence is shown below. FROM: Step 2: Identifying Relevant Studies With the support of BLINDED FOR REVIEW, a professional librarian at the University of BLINDED FOR REVIEW, we developed and refined our search strategy through an iterative process involving the selection of both keywords and databases. TO: Step 2: Identifying Relevant Studies With the support of Joan Pons-Vila, a professional librarian at the University of Barcelona, we developed and refined our search strategy through an iterative process involving the selection of both keywords and databases.
- MakaleAçık Erişim2026Scopus SJRQ2Comparative study of magnetic and electric quadrupole moments in boron (5B) isotopes
Ali, Ahmed H.; Tfiha, Amir D.; Zakaly, Hesham M. H.; Jarallah, Naz T.; Issa, Shams A. M.; Abdulqader, Abdulqader S.; Çelik, Necati; Bhuyan, M.
The magnetic moments and electric quadrupole moments of the B-5 isotopes were calculated using different nuclear interactions and sets of effective charges. Instead of relying on core polarization, the effective charges were adopted through a microscopic theoretical approach. The one-body density matrix (OBDM) elements for these isotopes were calculated using the NuShellX@MSU code. The calculations were carried out within the shell model framework, using both the p- and psd-model spaces (MS). These model spaces were selected for nuclei with proton number Z = 5 and neutron number N > 3. The theoretical results for magnetic and quadrupole moments were compared with available experimental data. Theoretical magnetic moments of the B-8,B-10,B-11,B-12,B-13 isotopes showed good agreement with experiment when using the p-MS with the pwt interaction, and the psd-MS with the psdmwk interaction. Similarly, the theoretical electric quadrupole moments reasonably well with the experimental values when using the p-MS with the pkuo interaction, and the psd-MS with the psdmwk interaction.
- MakaleAçık Erişim2026Scopus SJRQ1Inspiratory muscle training enhances jumping power and shooting performance in elite air pistol athletes
Aydin, Ahmet Serhat; Yilmaz, Coskun; Söyler, Mehmet; Güney, Gamze; Eyüboglu, Ender; Karakulak, Izzet; Ceylan, Tulay; Altug, Tolga; Burac, Daniela Giconda; Sahinler, Yunus
Background Inspiratory muscle training (IMT) has been shown to enhance respiratory efficiency, postural stabilization, and neuromuscular coordination in athletic populations. However, its effects in precision sports such as air pistol shooting remain insufficiently explored. This study investigated the impact of a 4-week IMT program on respiratory muscle strength, explosive lower-limb performance, reaction time, and shooting accuracy in competitive air pistol athletes. Methods Twenty trained male air pistol athletes (age 18-35 years) were randomly assigned to an IMT group (n = 10) or a control group (n = 10). The IMT group performed supervised inspiratory muscle training twice daily (30 breaths/session), six days per week, for four weeks, using a threshold-loading device set initially at 40% of maximal inspiratory pressure (MIP), with progressive overload applied weekly. Both groups maintained their regular shooting training routines. Pre- and post-intervention assessments included countermovement jump (CMJ) and squat jump (SJ) performance (OptoJump), visual and auditory reaction time (Cognitech), and shooting performance evaluated via the SCATT system. A two-way repeated-measures ANOVA (group & times; time) was used for statistical analysis. Results Significant group & times; time interactions were observed for CMJ height (p < 0.001, eta & sup2;p = 0.618), CMJ power (p = 0.007, eta & sup2;p = 0.345), SJ height (p = 0.050, eta & sup2;p = 0.184), and SJ power (p = 0.050, eta & sup2;p = 0.181), indicating meaningful improvements in explosive performance in the IMT group. Shooting accuracy demonstrated a large and statistically significant interaction effect (p < 0.001, eta & sup2;p = 0.532), with substantial improvement observed only in the IMT group. Reaction time variables showed favourable but non-significant trends (p > 0.05). Conclusion A short-term IMT intervention significantly enhanced lower-limb explosive performance and shooting accuracy in competitive air pistol athletes without altering overall training load. These findings suggest that IMT may represent an effective, low-cost adjunct strategy to improve neuromuscular stability and fine-motor precision in precision-sport athletes.
- MakaleAçık Erişim2026Scopus SJRQ1A multi-evidence computational and experimental strategy for Silene nerimaniae: combining phytochemical characterization, bioactivity assessment, and ADEFRank-HCT-116-based metabolite prioritization
Erharman, Ahmet; Yagi, Sakina; Uba, Abdullahi Ibrahim; Nikolic, Filip; Gasic, Uros; Acar, Mikail; Dogan, Nurettin; Koyuncu, Ismail; Yapici, Ismail; Gulcin, Ilhami
This study presents the first comprehensive evaluation of the phytochemical composition, antioxidant properties, enzyme inhibitory effects, and cytotoxic potential of Silene nerimaniae G.E.Gen & ccedil;, Kandemir & & Idot;.Gen & ccedil; (family Caryophyllaceae). Ethyl acetate, acetone, 70% acetone, and aqueous extracts were obtained from the aerial parts of the plant through maceration. Among the tested extracts, the acetone extract contained the highest total phenolic (24.37 mg GAE per g) and flavonoid (24.64 mg RE per g) contents. LC-MS analysis identified 52 bioactive constituents, including sugars, organic acids, phenolic acids, flavonoids, and fatty acids. The aqueous extract demonstrated the strongest radical scavenging activity against DPPH (23.02 mg TE per g) and ABTS (55.76 mg TE per g), as well as the highest Fe3+ reducing power (37.53 mg TE per g). In combination with the acetone extract, it also exhibited notable Cu2+ reducing activity (47.78 mg TE per g). Regarding enzyme inhibition, the ethyl acetate, acetone, and hydroacetone extracts displayed the strongest inhibitory activities against acetylcholinesterase (1.87 mg GALA per g), butyrylcholinesterase (2.92 mg GALA per g), and tyrosinase (60.44 mg KAE per g), respectively. All three extracts also inhibited alpha-amylase activity within the range of 0.73-0.77 mmol ACAE per g (p >= 0.05). In addition, the hydroacetone extract showed considerable inhibition of human carbonic anhydrase isoenzymes I (IC50 = 38.78 mu g mL-1) and II (IC50 = 19.59 mu g mL-1). The ethyl acetate extract exhibited the strongest cytotoxic effect against the colorectal cancer cell line HCT-116, with an IC50 value of 0.639 mu g mL-1 and a selectivity index of 1.7. To contextualize this HCT-116-associated activity at the metabolite level, an ADEFRank-HCT116 (abundance-domain-evidence fusion ranking) workflow was applied by integrating EtOAc abundance, HCT-116-oriented QSAR evidence, applicability-domain confidence, and structure-assignment reliability. This analysis prioritized diosmetin, luteolin, eriodyctiol, acacetin, and isorhamnetin as core candidates for structure-based follow-up. Molecular docking screening predicted favorable docking profiles for the prioritized candidates, while 100 ns molecular dynamics simulations were used to assess the dynamic stability of the representative luteolin-PI3K alpha, diosmetin-AKT1, and isorhamnetin-GSK-3 beta complexes. Taken together, these results indicate that S. nerimaniae may represent a valuable source of active compounds for various functional nutraceutical, cosmetic and pharmaceutical uses.
- MakaleAçık Erişim2026Scopus SJRQ1Comparison of plyometric repeated sprint and plyometric aerobic training on physical performance in youth soccer players
Selmi, Mohamed Amin; Hammami, Raouf; Ceylan, Halil Ibrahim; Duncan, Michael; Sassi, Radhouane Haj; Morgans, Ryland; Bayrakdaroglu, Serdar; Bragazzi, Nicola Luigi
High-intensity interval training (HIIT) and repeated-sprint sets (RSS) are established conditioning methods in soccer, yet their integration with plyometric training among highly trained youth soccer players remains underexplored. This study investigated the effects of an 8-week program combining plyometric training with either RSS (PLYO-RSS) or HIIT (PLYO-HIIT) on physical fitness in young soccer players. Twenty-nine male players (14-15 years) were randomly assigned to PLYO-RSS (n = 14) or PLYO-HIIT (n = 15). Both interventions lasted 20 minutes per session and replaced part of regular soccer training. Physical fitness assessments included countermovement jump (CMJ), 15-s repeated vertical jumps (15''RJ), five-jump test (5JT), 10 m and 30 m sprint, maximal aerobic speed (MAS), VO2max, and repeated sprint performance (total sprint time, best sprint, fatigue index). Physiological markers (lactate, rating of perceived exertion, and HRmax) were also monitored. Significant improvements over time were observed in muscle power, sprint speed, aerobic capacity, and repeated-sprint ability (p <= 0.001; eta & sup2;p = 0.339-0.489). However, no main effects or group & times; time interaction effects were observed, indicating no evidence of differential responses between the two training modes. In conclusion, integrating plyometric training with either RSS or HIIT effectively enhances physical fitness in highly trained youth soccer players, offering flexible options for training prescription.
- MakaleAçık Erişim2026Scopus SJRQ1Chemical profiling, biological evaluation, and QSAR-informed metabolite prioritization of Hypericum ekerii: a first report on antioxidant, enzyme inhibitory, and cytotoxic activities
Zengin, Gokhan; Yagi, Sakina; Cetiz, Mehmet Veysi; Uba, Abdullahi Ibrahim; Nikolic, Filip; Gasic, Uros; Balos, Mehmet Maruf; Erharman, Ahmet; Dogan, Nurettin; Koyuncu, Ismail
Hypericum ekerii Y & uuml;ce and Ayta & ccedil;, first described in 2017, remains poorly characterized in terms of its phytochemical composition and biological properties. This study investigated aerial-part extracts of H. ekerii prepared with ethyl acetate, acetone, 70% acetone-water, and water. The hydroacetone extract showed the highest total phenolic and flavonoid contents. LC/MS analysis enabled the annotation of 99 constituents, including phenolic acids, flavonoids, xanthones, anthraquinones, and acylphloroglucinols. The hydroacetone extract exhibited the strongest radical-scavenging and reducing activities, whereas acetone and ethyl acetate extracts showed the highest metal-chelating capacity. In enzyme assays, hydroacetone was the most active extract against acetylcholinesterase, tyrosinase, and hCA II, while ethyl acetate showed greater inhibition of butyrylcholinesterase and hCA I. The aqueous extract was the most active against alpha-glucosidase, and hydroacetone and ethyl acetate showed comparable alpha-amylase inhibition. Cytotoxicity remained limited overall; the lowest IC50 value was observed for the ethyl acetate extract against HCT-116 cells (95.09 & micro;g mL-1), with weak selectivity (SI = 1.2). A QSAR-informed prioritization framework identified myricetin as the leading cross-layer candidate, p-coumaric acid as a target-specific priority metabolite, and ellagic acid, quercetin, and caffeic acid as antioxidant-priority candidates. Molecular docking supported favorable binding profiles for selected metabolites, while molecular dynamics simulations were used to assess the stability of representative complexes. Overall, H. ekerii appears to be a chemically diverse species with notable antioxidant and enzyme-inhibitory potential, providing a focused basis for future compound-level validation.
- MakaleAçık Erişim2026Scopus SJRQ2Long-term decline of Chernobyl-derived 137Cs in mosses and lichens from the Eastern Black Sea region of Türkiye
Çevik, Ugur; Çelik, Necati; Uzun, Kubra K.; Çelik, Ahmet; Koz, Bahadir; Özen, Songul A.; Yesilkanat, Cafer M.; Hacisalihoglu, Aylin; Özkalayci, Fatih; Kaya, Selim
This study presents the third consecutive assessment of 13 Cs activity concentrations in the same 50 moss (7 species) and lichen (2 species) sampling points in Ordu province, T & uuml;rkiye, one of the most heavily contaminated areas following the Chernobyl accident. Samples were collected from exactly the same locations used in the 1997 and 2007 studies and analyzed by high-resolution gamma spectrometry. In 2025, detectable 13 Cs was found in 14 of 30 moss sites (47%) and 3 of 20 lichen sites (15%). For samples below the minimum detectable activity (MDA), a value of MDA/2 (0.93 Bq kg-1) was substituted for lichens, while moss samples below the MDA were excluded from regression. The ecological half-life (Teco) for the 2007-2025 period was 4.38 +/- 1.05 years for mosses and 4.18 +/- 0.61 years for lichens. For mosses, this is nearly identical to the 1997-2007 mean (4.4 years), while for lichens it decreased from 5.6 to 4.18 years, suggesting a slight acceleration in environmental removal. All Teco values remain far shorter than the physical half-life of 13 Cs (30 years), confirming that environmental removal processes dominate over radioactive decay. Residual 13 Cs is concentrated in higher-altitude areas, reflecting the original deposition pattern and slower removal in cooler, more humid microenvironments. Nearly 39 years after the accident, the radiological risk posed by residual trace levels is negligible. This 28-year dataset provides one of the longest continuous records of 13 Cs in epiphytic bioindicators and serves as a valuable baseline for future contamination events.
- MakaleAçık Erişim2026Scopus SJRQ3Mono- and Bis-Ureido Sulfapyridines as Nanomolar Dual Cholinesterase Inhibitors: Enzyme Kinetics, Molecular Docking, and ADME/Tox Insights
Yapar, Gonul; Akocak, Suleyman; Lolak, Nebih; Topal, Meryem; Türkes, Cuneyt; Topal, Fevzi; Durgun, Mustafa; Koçyigit, Umit Muhammet; Isik, Mesut; Beydemir, Sukru
A series of mono- and bis-ureido sulfapyridine derivatives (SP-1-SP-10) were synthesized and evaluated as dual cholinesterase inhibitors targeting acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). All compounds exhibited nanomolar inhibition. The most potent AChE inhibitors were SP-8 (K-i = 5.25 +/- 0.73 nM), SP-9 (5.09 +/- 0.44 nM), and SP-10 (5.74 +/- 0.55 nM), significantly outperforming tacrine (K-i = 105.03 +/- 8.85 nM) under identical conditions. For BChE, SP-9 showed the strongest inhibition (K-i = 26.38 +/- 2.07 nM) compared with tacrine (172.03 +/- 32.42 nM). Kinetic analyses revealed competitive inhibition toward AChE for all derivatives, whereas BChE inhibition displayed both competitive and noncompetitive patterns depending on structural features. Glide XP docking using AChE (PDB: 7XN1) and BChE (PDB: 4BDS), complemented by MM-GBSA binding free energy calculations, supported favorable ligand accommodation within the catalytic pockets and highlighted the importance of aromatic and hydrophobic interactions. In silico ADME/Tox analysis revealed a potency-drug-likeness trade-off: mono-ureido derivatives complied with Lipinski's rule of five and showed high predicted oral absorption, whereas bis-ureido derivatives, despite superior enzymatic potency, exhibited multiple drug-likeness violations. These findings identify the ureido-sulfapyridine scaffold as a potent enzymatic dual cholinesterase inhibitory framework, warranting further structural optimization to improve pharmacokinetic properties.
- MakaleAçık Erişim2026Scopus SJRQ1YOLOv8 computer vision for automated offside detection in professional football validated through supervised learning
Abdel-Fattah, Abdul-Rahman; Belhaouari, Samir Brahim; Ceylan, Halil Ibrahim; Bayrakdaroglu, Serdar; Muntean, Raul Ioan; Dhahbi, Wissem; Dergaa, Ismail; Omri, Abdelfatteh El
Offside calls are integral to maintaining fairness and competitive integrity in football, yet current officiating processes are constrained by limitations in accuracy despite technological advancements. This investigation developed and validated an automated offside detection system using YOLOv8 object detection architecture to address documented limitations of Video Assistant Referee (VAR) systems in offside decision accuracy. Supervised learning validation employed 400 annotated instances from professional match footage. The YOLOv8 medium variant was configured for four-class detection, with a focus on extreme player positions, reducing computational complexity by approximately 70% relative to comprehensive player tracking while accepting accuracy trade-offs in marginal scenarios. The system was optimized for computational efficiency through highly accurate tracking of player positions. Data were partitioned into 40% (n = 160) for training and 60% (n = 240) for testing, with 5-fold cross-validation. The automated system achieved robust performance metrics across 240 test instances: overall accuracy of 83.0%, precision of 85.0%, recall of 87.0%, and F1-score of 86.0%. Confusion matrix analysis revealed true positives (n = 130), true negatives (n = 70), false positives (n = 22), and false negatives (n = 18). Individual case analysis demonstrated 80% agreement with ground truth classifications. System performance significantly exceeded the random classification baseline (p < 0.001). The strategic extreme player tracking approach achieved substantial computational efficiency while maintaining decision accuracy across diverse match scenarios. A YOLOv8-based offside detection system demonstrates proof-of-concept feasibility for decision-support applications in football officiating. Performance (83% accuracy, 95% CI: 79-87%) on 240 test instances remains below professional benchmarks (> 93%), with single-camera constraints and limited dataset size restricting generalizability to proof-of-concept validation rather than operational deployment.
- MakaleAçık Erişim2026Scopus SJRQ1Short-Term Inspiratory Muscle Training Enhances Functional and Metabolic Health in Older Adults
Konca, Erkan; Yilmaz, Coskun; Bayrakdaroglu, Serdar; Ceylan, Halil Ibrahim; Arslan, Ayla; Ocak, Hakan; Karakulak, Izzet; Sari, Rifat; Uzun, Recep Nur; Soylu, Hakan Huseyin
Background: Age-related declines in respiratory muscle strength and ventilatory efficiency can impair functional capacity and metabolic health in older adults. Inspiratory muscle training (IMT) has been proposed as a practical intervention to counteract these changes, yet its systemic effects remain unclear. This study aimed to examine the effects of short-term IMT on functional capacity, diaphragm thickness, and liver tissue characteristics in healthy elderly men. Methods: Thirty community-dwelling men aged 60-80 years were randomly assigned to an IMT or control group. The IMT group performed four weeks of breathing exercises using a POWERbreathe (R) device at 40% of maximal inspiratory pressure, with a weekly 10% increase in pressure. Pre- and post-intervention assessments included the six-minute walk test (6MWT), diaphragm thickness and liver density via computed tomography, and quality of life (QoL; SF-12). Results: Four weeks of inspiratory muscle training significantly improved diaphragm thickness (11.7%), fatty liver density (FLD) (+16.7%), and six-minute walk performance (+5.3%), with large time x group effects favoring the IMT group. While the physical quality of life showed modest, comparable improvements, mental health outcomes demonstrated a moderate, time-dependent improvement without a significant group-by-time interaction. Conclusions: Short-term IMT improved diaphragmatic function and functional capacity in older men and was associated with favorable changes in a liver-related biomarker; however, given that only a single liver-related metric was assessed, these findings should not be interpreted as evidence of overall improvements in liver health.
AtıfScopus1WoS1OpenAlex3İncele - MakaleAçık Erişim2026Scopus SJRQ1Effects of wrestling training on psychological well-being, anxiety, and resilience in adolescent boys
Özkan, Ridvan; Yilmaz, Coskun; Uzun, Recep Nur; Bayrakdaroglu, Serdar; Akar, Ozge Orhan; Öz, Faik; Çiçekli, Atif; Çiçekli, Aylin; Dal, Suzan; Ursu, Vasile Emil
Background Wrestling is a physically and mentally demanding combat sport that requires discipline, focus, and emotional control. Although its physiological effects are well documented, its psychological benefits in adolescents remain underexplored. This study aimed to examine whether a short-term, non-competitive wrestling program could enhance psychological well-being, reduce sport anxiety, and strengthen resilience in adolescent boys. Methods Thirty sedentary male adolescents (aged 12-15 years) were randomly assigned to a wrestling training group (n = 15) or a control group (n = 15). The intervention consisted of six weeks of supervised wrestling sessions performed three times per week. Psychological well-being (WHO-5), sport anxiety (SAS-2), and resilience (BPRS) were assessed before and after the intervention using the validated Turkish versions of the scales. Two-way repeated-measures ANOVA was used to analyze group & times; time interactions. Results Participants in the wrestling group demonstrated significant improvements in well-being (p < 0.001) and resilience (p < 0.001), alongside marked reductions in total sport anxiety and its subdimensions (p < 0.001), compared with the control group. All effects were large (eta p & sup2; = 0.52-0.94). Conclusion A structured six-week wrestling program produced meaningful psychological benefits in adolescent boys. Regular participation in non-competitive wrestling may serve as an effective approach to promote well-being, emotional stability, and adaptive coping skills during early adolescence, supporting the preventive and developmental role of combat sports in youth mental health.
AtıfScopus3WoS5OpenAlex10İncele