Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(64)
- Merdan, Mehmet(47)
- Baltaci, Cemalettin(35)
- Kulakaç, Nurşen(28)
- Duran, Celal(27)
- Ozdes, Duygu(24)
- Turan, Ibrahim(24)
- Demir, Selim(23)
- Türkkan, Tuğba(22)
- Bayrakdaroglu, Serdar(21)
- Topal, Fevzi(21)
- Öztürk, Serkan(21)
- Ürkek, Bayram(21)
- Gücer, Mehmet Ali(20)
- Akar, Zeynep(19)
- Kaygusuz, Abdullah(19)
- Topal, Meryem(19)
- Anaç, Halil(18)
- Aydin, Aydanur(18)
- Batan, Nevzat(18)
- Erata, Hüseyin(18)
- Tuncer, Metin(18)
- Akyürek, Suat(17)
- Baltacı, Cemalettin(17)
- Karimullah, Suud Sarim(17)
- Acet, Tuba(16)
- Akar, Bülent(16)
- Ashyralyyev, Charyyar(16)
- Düzgün, Azer Özad(16)
- Hintistan, Sevilay(16)
- Yılmaz, Coşkun(16)
- Aliyazicioglu, Yuksel(15)
- Kaya, Hacer(15)
- Kurnaz, Muammer(15)
- Kurt, Kemal(15)
- Ozden, Talat(15)
- Yilmaz, Coskun(15)
- Yuksel, Ferhat(15)
- Yücel, Cem(15)
- Öz, Mehmet(15)
Yayınlar
- MakaleAçık Erişim2011Breast Conserving Surgery and Modified Radical Mastectomy in Turkish Women with Breast Cancer: A Prospective Analysis of Quality of Life
Kement, Metin; Gezen, Cem; Asik, Ayla; Karaöz, Alev; Ustaalioglu, Basak Oven; Bilici, Ahmet; Öncel, Mustafa
Objective: The aim of this study is to compare the postoperative quality of life of the patients who underwent breast conserving surgery followed by radiotherapy (BCT) and the patients who underwent modified radical mastectomy (MRM) in our clinic. Material and Methods: The patients who were operated on with diagnosis of breast cancer in our clinic between January 2006 and January 2008 were included in the study. Those who received neoadjuvant therapy and who required radiotherapy after modified radical mastectomy and those in ASA classes 3 and 4 were excluded. The patients who were treated with modified radical mastectomy were included in the first group (Group MRM) and the patients who were treated with breast conserving therapy and radiotherapy thereafter were included in the second group (Group BCT). Quality of life of the patients were assessed using Medical Outcome Syudy-Short Form 36 (MOS SF-36) form six months after their treatment (surgery, radiotherapy, chemotherapy) was completed. Results: There were no significant differences between two groups in terms of age, evaluated socioeconomic parameters (education, income, marital status) and clinical parameters (stage, complications, adjuvant chemotherapy). Quality of life of the patients who underwent BCT (n=27) was worse than that of general Turkish population in six of eight (except vitality and social function) SF-36 scale and worse than mean values of normal individuals in NSABP BCPT trial in seven of eight (except vitality) scales. Besides, while physical component score was worse than that of general population (45.3 vs 52.6), mental component score (MCS) was relatively similar to general population (53.4 vs 51.7). When quality of life of the patients who underwent MRM (n=23) and BCT were compared, mean values of BCT group were found to be better in all scales and the difference was found to be statistically significant in six out of eight (except vitality and social function) scales (p<0.05). Conclusion: It can be stated that quality of life of the patient who underwent BCT due to breast cancer is impaired in terms of physical status, however did not change in terms of mental status. It can also be stated that quality of life of the patients who underwent breast conserving therapy were better than the ones who underwent modified radical mastectomy in terms of both physical and mental status.
- MakaleAçık Erişim2011A Different Cause of Trauma: Injury by a Mole Gun
Türkmen, Suha; Aktas, Aydin; Karaca, Yunus; Türedi, Suleyman; Gündüz, Abdulkadir
Although injuries caused by the home-made weapons such as mole guns, which are intended to fight off moles, are rare in Turkey they do still happen. They generally involve minor accidents and cause simple injuries to the hand. In this case we present a patient who involves a trauma to the left hand with fragmental fracture of the first metacarpal caused while checking whether a mole gun had fired or not. This injury is an example of an accident related to primitive, home- made weapons, used particularly in rural areas.
- MakaleAçık Erişim2011On the numerical solution of the model for HIV infection of CD4+ T cells
Merdan, Mehmet; Gökdogan, Ahmet; Yildirim, Ahmet
In this article, a variational iteration method (VIM) is performed to give approximate and analytical solutions of nonlinear ordinary differential equation systems such as a model for HIV infection of CD4(+) T cells. A modified VIM (MVIM), based on the use of Fade approximants is proposed. Some plots are presented to show the reliability and simplicity of the methods. (C) 2011 Elsevier Ltd. All rights reserved.
- MakaleAçık Erişim2011Bay laurel (Laurus nobilis L.) in Japanese quails feeding 1. Performance and egg quality parameters
Karaalp, Musa; Elmasta, Mahfuz; Genc, Nusret; Sezer, Metin; Yavuz, Musa; Ozkan, Mehmet
The aim of this study was to evaluate the effect of supplemented bay laurel (Laurus nobilis L.) leaves to a conventional diet of laying Japanese quail on the performance and some egg quality. A total number of 60 and 54 days old laying type quails were distributed into individual cages for three different treatments. The control diet did not containLaurus nobilis (LN) leaves (LNG) and the other diets were supplemented with 2 g (LN2) and 4 g (LN4) leaves kg-1, respectively. The trial lasted for a total of 10 weeks. Supplemented leaves of LN (2 or 4 g kg-1 feed) had no effect on any performance parameters, external and internal egg quality traits of quails. The diets have not changed the amount of egg yolk total cholesterol at 121 days old. However, egg yolk triglyceride concentration of quails fed LN4 diet was lower (p<0.01) than quails fed with the other diets at 121 days old. Besides, the amount of total cholesterol and triglyceride of egg yolk increased (p<O.01) in all of the groups with age. In egg yolk in the group receiving diet LN4, the level of palmitic acid was lower (p<0.05) and oleic acid was higher (p<0.05) than those of the other 2 groups at 118 days. Besides at that age, the level of pahnitic acid was lower and oleic acid was >55, 76 and 97 days. There was no change in the other fatty acids. The changes in total saturated and total monounsaturated fatty acids were parallel with palmitic acid and oleic acid, respectively. Total polyunsaturated fatty acid content in the present study did not change with diet and age. The results of this study demonstrated that supplemented a conventional diet with LN could change some biochemical parameters of quail egg yolk.
- MakaleAçık Erişim2011Stability properties of certain durum wheat genotypes for major quality characteristics; [Makarnalik buĝday genotiplerinin temel kalite kriterleri bakimindan stabilite özellikleri]
Sakin, Mehmet Ali; Düzdemir, Oral; Sayaslan, Abdulvahit; Yüksel, Ferhat
Many ecological regions of Turkey are suitable for the production of durum wheat, and therefore the yield and quality of this wheat should be improved. In this study, stability properties associated with the pasta quality of 25 durum wheat (Triticum durum Desf.) genotypes grown in 3 dif erent locations (Tokat-Kazova, Diyarbaki{dotless}r, and Sivas-Ulaş) for 2 years (2005-2006, 2006-2007) were investigated. Durum wheat genotypes were composed of 12 registered varieties and 13 advanced experimental lines. Field trials were conducted in a randomized complete block design with 3 replications. Protein content, gluten index, sedimentation and specif c sedimentation volumes, yellow pigment content, and lipoxygenase activity of the durum wheats were measured as major quality characteristics. T e regression coef cient (bi) and mean square of deviation from regression (S2 d) were employed as the stability parameters. Genotypes, growing environments, and their interactions were found to be statistically signif cant (P < 0.01) for all investigated quality characteristics. No cultivars were determined to be simultaneously stable for all of the quality characteristics, yet some of the genotypes prevailed for certain quality characteristics. T e genotypes with the same origin took part in the same group as judged by the cluster analysis. Of the advanced experimental durum wheat lines, Line - 1, Line - 7, Line - 20, and Gdem - 12, which displayed better quality characteristics than the overall means, can be used as breeding materials. Of the registered varieties, Aydin - 93, Çeşit - 1252, and Gidara were determined to be stable by both parameters in certain quality characteristics.
- MakaleAçık Erişim2011Solving a fractional order model of HIV infection of CD4+ T cells
Gokdogan, Ahmet; Yildirim, Ahmet; Merdan, Mehmet
In this paper, a multi-step differential transform method (MsDTM) is performed to give approximate and analytical solutions of nonlinear fractional order ordinary differential equation systems such as a model for HIV infection of CD4+ T cells. The numerical solutions obtained from the proposed method indicate that the approach is easy to implement and accurate when applied to systems of fractional differential equations. Some figures are presented to show the reliability and simplicity of the methods.
- MakaleAçık Erişim2011Geochemical and Sr-Nd isotopic characteristics of post-collisional calc-alkaline volcanics in the eastern pontides (NE Turkey); [Doǧu Pontidlerde (KD Türkiye) Çarpişma Sonrası Kalk-Alkalen Volkanizmanın Jeokimyası ve Sr-Nd İzotopik Karakterleri]
Kaygusuz, Abdullah; Arslan, Mehmet; Siebel, Wolfgang; Şen, Cüneyt
Major, trace element, K -Ar age and Sr-Nd isotopic data are presented for the Eocene Torul volcanics in the eastern Pontide orogenic belt (NE Turkey). The studied rocks are composed of basaltic andesitic, andesitic, trachyandesitic, and minor trachydacitic lavas associated with their pyroclastics. These rocks contain plagioclase (An2-44), hornblende (Mg#= 0.78-0.98), clinopyroxene (Wo43-46 En41-43 Fs10-15), biotite, quartz, and minor sanidine phenocrysts. K-Ar ages on hornblendes ages range from 43.99 (±2.59) to 33.45 (±2.32) Ma, within the Middle to Late Eocene. The volcanic rocks show calc-alkaline affinities and have medium to high K contents. They are enriched in large ion lithophile (LILE) and light rare earth elements (LREE), with pronounced depletion of high field strength elements (HFSE). The chondrite-normalized REE patterns (Lacn/Lucn= 4.0-9.8) show low to medium enrichment, indicating similar sources for the rock suite. Initial 87Sr/86Sr values vary between 0.70457 and 0.70511 and initial 143Nd/144Nd values between 0.51264 and 0.51278. The main solidification processes involved in the evolution of the volcanics consist of fractional crystallization with minor amounts of crustal contamination ± magma mixing. All evidence supports the conclusion that the parental magma(s) of the rocks probably derived from an enriched upper mantle, previously modified by subduction- induced metasomatism in a post-collisional geodynamic setting.
- MakaleAçık Erişim2011Heparin for adhesion prevention: Comparison of three different dosages with Seprafilm in a murine model
Kement, Metin; Censur, Zafer; Oncel, Mustafa; Buyukokuroglu, Mehmet E.; Gezen, Fazli C.
Background: This study aimed to assess the safety and effectiveness of different dosages of heparin for adhesion prevention by comparing with Seprafilm®, in a murine model. Materials and methods: Seventy five Balb/c mice were randomized into five groups. Group C were reserved as controls, and 62.5 IU, 125 IU, 250 IU of heparin, and Seprafilm® were intraperitoneally applied in studied groups. The severity and locations of adhesions were assessed after the sacrification on day 14. The cause of death was investigated to evaluate the side effects of the drugs. Results: The death of 2 subjects due to peritonitis (1 in Group C, 1 in Group H62.5) left 14 subjects in Group C and Group H62.5 (P ≥ 0.05), and no hemorrhage related death was observed. The use of the products significantly reduced the severity score of adhesion and the number of animals, had adhesions in different locations of the abdominal cavity, when the results were compared with the control group (P < 0.05 for all comparisons). Higher dosages of heparin seemed to be more effective. The results in group S, groups H250 and H125 were quite similar. Conclusions: Relatively high doses (125 IU and 250 IU) of intra-abdominal heparin may be comparable in safety and effectiveness to Seprafilm® in adhesion prevention in mice.
- BildiriAçık Erişim2011Core competences in non-governmental organizations: A case study
Besler, Senem; Sezerel, Hakan; Ozsahin, M
The aim of this study is to suggest the importance of core competences in the success of nongovernmental organizations. Accordingly, an answer is searched regarding with which activities successful non-governmental organizations can sustain their lives, and whether the core competencies are influential in this success. Çaǧdas. Drama Derneǧi (Contemporary Drama Association), a nongovernmental organization which has continued its activities by competing with profit organizations in the field of creative drama in Turkey for twenty years has been examined in depth with the sample case method. The examination has been conducted through interviews, archive scanning and participant observation. The works of the association have been observed on-site and by participating in the activities, the obtained data have been evaluated within the scope of the research. Its core competence, decision making groups of the society in the domain of education and arts, its other nongovernmental organizations, led by higher education institutions have come forth as establishing result-oriented relationships and relationship management. It is considered that the core competency of the organization, as differentiating competitive ability and competitive power, has provided a competitive edge over its competitors.
- MakaleAçık Erişim2011The first record of the genus Odiellus (opiliones, phalangiidae) in Turkey with some SEM studies on its morphology
Kurt, K.; Erman, O. Köksal
The harvestmen species Odiellus lendli (Soerensen, 1894), with its genus Odiellus Roewer, 1923, was found in Anatolia. It represents a new record of Turkish harvestmen fauna. The characteristic features of this species are described and illustrated. Scanning electron microscopy (SEM) studies on the dorsal integument, ventral habitus, chelicerae, pedipalpus, trident, the ocularium and legs of female specimens are also presented. Localities of the collecting sites are photographed and plotted on a map.
- MakaleAçık Erişim2011Early abyssal- and late SSZ-type vestiges of the Rheic oceanic mantle in the Variscan basement of the Sakarya Zone, NE Turkey: Implications for the sense of subduction and opening of the Paleotethys
Dokuz, Abdurrahman; Uysal, Ibrahim; Kaliwoda, Melanie; Karsli, Orhan; Ottley, Chris J.; Kandemir, Raif
The boundary between the Gondwana and Laurussia, or a terrane separated from it, is traced by a suture recording the closure of the Rheic ocean in the Pulur, Beyçam and Kurtoǧlu areas of the eastern Sakarya Zone of Turkey. Pulur lherzolite has a lower Cr# [100Cr/(Cr+Al)=5-37] of the spinel and slightly enriched flat medium-heavy rare earth element (M-HREE) whole-rock pattern typical for those of the fertile abyssal-type lherzolite. By contrast, the Beyçam harzburgite displays the mineralogical and geochemical features of a moderately depleted residue at a supra subduction zone (SSZ). Some of spinels from the Beyçam peridotites show TiO2 contents (0.15-0.48wt.%) identical to a later interaction with a melt of island-arc tholeiite (IAT) composition. Meta-basalt from the Beyçam area is the representative of such a melt and displays the whole-rock M-HREE pattern of a complementary product of the Beyçam harzburgite. Data presented in this study support the primarily northward directed closure of the Rheic ocean, but suggest that the Variscan basement in the eastern part of the Sakarya Zone consists of mantle peridotites formed in a south-vergent SSZ. This dual polarity of subduction in the Rheic ocean, at least in the second half of its closure, is also favored by the geological structure and lithological diversity of the Variscan rocks. These are: (1) spatial distribution of the peridotites, e.g., SSZ-type harzburgites to the north and abyssal-type lherzolites to the south, (2) lack of high-pressure metamorphic rocks, (3) decrease in the degree of Variscan metamorphism toward the north, and (4) emplacement of Variscan syn-collisional magmatism into the low grade metamorphic rocks to the north. Paleotethys was the other ocean of the region created in the Late Paleozoic. Northward subduction of the Rheic ocean from Early Devonian to Early Carboniferous appears to be the most plausible mechanism responsible for the opening of Paleotethys. In this scenario the Paleotethys is envisaged as a back-arc basin opened to the north in the wake of separated terranes from Laurussia. Onset of trench-Rheic mid-ocean ridge collision in the Early Devonian along the northern margin of Laurussia has been proposed to account for the initiation of SSZ-type subduction to the south. The short duration of this subduction appears insufficient to open a fully developed back-arc basin to the south because the elimination of Rheic mid-ocean ridge to the north accelerated the oceanic closure.
- MakaleAçık Erişim2011Frequency optimization of laminated skewed open cylindrical shells
Topal, Umut; Uzman, Ümit
This paper deals with frequency optimization of symmetrically laminated skewed open cylindrical shells. The design objective is the maximization of the fundamental frequency and the design variable is the fiber orientations. The firstorder shear deformation theory (FSDT) is used for the finite element solution of the shells. The modified feasible direction (MFD) method is used for the optimization routine. For this purpose, a program based on FORTRAN is used. Finally, the numerical analysis is carried out to investigate the effect of skew angles, length to radius ratios, subtended angle and boundary conditions on, the optimal designs and the results are compared.
- MakaleAçık Erişim2011Modelling and mapping third dimension in a spatial database
Döner, F.; Biyik, C.
In this paper, an overview of phases for modelling and mapping third dimension of spatial objects in a database is presented based on a selected spatial database management system (DBMS). These phases include (1) defining a spatial reference system for representing three-dimensional (3D) objects with real-world coordinates, (2) geometric modelling of 3D objects in the database, (3) 3D spatial indexing for fast accessing/querying the 3D data, 3D spatial queries and representation of 3D data. Then, a case study is performed to assess needs, possibilities and potential limitations of 3D data modelling in the spatial database.
- MakaleAçık Erişim2011Mild conditions for oxidation/epoxidation of styrene
Kazanci, A.; Saribiyik, O.Y.; Serin, S.
In this study, in order to obtain novel support materials for immobilization of transition metals, polymeric Schiff bases were synthesized using a poly-condensation reaction between ortho(o-)phthalaldehyde tere(t-)phthalaldehyde, oxaldehyde and diamines like, e.g., ethylene-p- phenylene- and o-phenylenediamine. Additionally, catalytic activity of polymeric Schiff base metal on oxidation/epoxidation of styrene complexes were investigated. The products have been characterized on the basis of analytical and spectral method, Fourier transform infrared spectroscopy, 1H- and 13C-nuclear magnetic resonance, gel-permeation chromatography, elemental analysis, thermogravimetric analysis, atomic adsorbtion spectrometry, gas chromatography and gas chromatography mass spectrometry.
- MakaleAçık Erişim2011Factors of land use/cover change: A case study from Turkey
Sivrikaya, Fatih; Çakir, Günay; Akay, Abdullah Emin
Land use/cover change impacts ecosystem services and functions such as forest health, biodiversity, and water production. Monitoring and assessing land use/cover changes provides an effective and accurate evaluation of human impact on the forest ecosystems. This study aims to determine spatial and temporal changes in land use/cover at a particular time period in a typical forest ecosystem of Turkey using geographical information systems (GIS). Specifically, the objective of this study is to analyze the main factors driving land use/cover change and the impacts of such changes in local and global perspective. Results showed that the total forested areas decreased from 5089 ha (41% of the study area) to 4426 ha (36% of the study area) during a 21 year period, which figures a net decrease of 663 ha (5%) forest areas and the average annual deforestation rate was 32 ha. Conifer forest (161 ha) completely transitioned to other cover types over 21-year period. Three major factors including distance from villages, distance from roads, and ground elevation were considered in evaluating forest disturbance. The results showed that these factors influence the reforestation/deforestation rates. Besides, forest disturbance was found to be closely related to distance from villages, distance from roads, and elevation.
- MakaleAçık Erişim2011Nonlinear earthquake behaviour of highway tunnels
Sevim, B.
This paper describes the Arhavi Highway Tunnel which has two tubes, its geometrical properties, finite element model, and the nonlinear earthquake behaviour under a huge ground motion considering soil-structure interaction. The Arhavi Highway Tunnel is one of the tallest tunnels constructed in the Black Sea region of Turkey as part of the Coast Road Project. The tunnel has two tubes and each of them is about 1000 m tall. In the study, the modal analyses of the tunnel considering soil-structure interaction are performed and natural frequencies and mode shapes are obtained. Then, nonlinear transient analysis of the tunnel using Drucker-Prager criteria is performed applying acceleration components of 1992 Erzincan, Turkey earthquake's ground motion. In the time history analyses, Rayleigh damping coefficients are calculated using main natural frequency obtained from modal analysis. Element matrices are computed using the Gauss numerical integration technique. The Newmark method is used in the solution of the equation of motion. Because too much memory for the analyses is required, the first 7.5 s of the ground motions, which is the most effective duration, is taken into account in calculations. The displacement and stress results are observed to be the allowable level of the concrete material.
- MakaleAçık Erişim20114-[2-(Cyclohexa-1,4-dien-1-yl)ethoxy]-benzene-1,2-dicarbonitrile
Keleşoǧlu, Zeynep; Çelenk Kaya, Elif; Kaya, Afşin Ahmet; Kantekin, Halit; Büyükgüngör, Orhan
In the title compound, C16H14N2O, the dihedral angle between the aromatic rings is 70.23 (6)°. The linking chain has a zigzag conformation. In the crystal, molecules are linked by weak inter-molecular C - H⋯N hydrogen bonds, forming a zigzag chain along the c axis.
- MakaleAçık Erişim2011Effect of Turkish propolis extracts on proteome of prostate cancer cell line
Barlak, Yaşam; Deǧer, Orhan; Çolak, Meltem; Karatayli, Senem C.; Bozdayi, Abdurrahman M.; Yücesan, Fulya
Background: Propolis is a natural, resinous hive product that has several pharmacological activities. Its composition varies depending on the vegetation, climate, season and environmental conditions of the area from where it was collected. Surface enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOF MS) is a proteomic approach which has been used in cancer proteomics studies. Prostate cancer is one of the most commonly diagnosed cancers in men. It has shown that nutritional supplements rich in polyphenolic compounds such as propolis play a significant role in prostate cancer chemoprevention. The aim of this study is to evaluate if protein expression profile in PC-3 prostate cancer cell lines could be differentiated when incubated with dimethyl sulfoxide and water extracts of Turkish propolis.Results: The antioxidant potentials of dimethyl sulfoxide and water extracts of propolis were found in correlation with the amount of total phenolic compounds of them. Dimethyl sulfoxide and water extracts of propolis of 20 μg/mL reduced the cell viability to 24.5% and 17.7%, respectively. Statistically significant discriminatory peaks between control PC-3 cells and dimethyl sulfoxide extract of propolis-treated PC-3 cells were found to be the proteomic features at m/z 5143, 8703, 12661, 20184 and 32794, detected by CM10 ProteinChip, and the peak at m/z 3772, detected by Q10 ProteinChip. Between control PC-3 cells and water extract of propolis-treated PC-3 cells, statistically significant discriminatory peaks were found to be the proteomic features at m/z 15846, 16052 and 24658, detected by CM10 ProteinChip and the peaks at m/z 10348, 10899 and 11603, detected by Q10 ProteinChip.Conclusions: It was concluded that dimethyl sulfoxide and water extracts of Turkish propolis may have anti-proliferative activity through differentiating protein expression profile in PC-3 prostate cancer cell lines along with their antioxidant capacity.
- MakaleAçık Erişim2011Arc magmatism as a window to plate kinematics and subduction polarity: Example from the eastern Pontides belt, NE Turkey
Eyuboglu, Yener; Santosh, M.; Bektas, Osman; Ayhan, Seda
The Eastern Pontides orogenic belt in the Black Sea region of Turkey offers a critical window to plate kinematics and subduction polarity during the closure of the Paleotethys. Here we provide a brief synthesis on recent information from this belt. We infer a southward subduction for the origin of the Eastern Pontides orogenic belt and its associated late Mesozoic-Cenozoic magmatism based on clear spatial and temporal variations in Late Cretaceous and Cenozoic arc magmatism, together with the existence of a prominent south-dipping reverse fault system along the entire southern coast of the Black Sea. Our model is at variance with some recent proposals favoring a northward subduction polarity, and illustrates the importance of arc magmatism in evaluating the geodynamic milieu associated with convergent margin processes.
- MakaleAçık Erişim2011The relationship between the peroxisome proliferator-activated receptor gamma 2 gene polymorphism, lipids and adipokines in patients with major depression; [Majör depresyonlu hastalarda peroksizom çoǧaltici-aktive edici reseptör gama 2 gen polimorfizmi, lipidler ve adipokinlerle ilişkisi]
Aliyazicioglu, Rezzan; Deǧer, Orhan; Vanizor Kural, Birgül; Hocaoǧlu, Çiçek; Çolak, Meltem; Balaban Yücesan, Fulya
Objective: Peroxisome proliferator-activated receptor gamma (PPARγ), lipids, lipoproteins, and adipokines have recently been shown to be associated with psychiatric diseases. Our major aim is to investigate the contribution of the PPARγ gene polymorphism, adipokines, lipids, and lipoproteins to the development of major depression. Material and Methods: The frequency of Pro12Ala in exon 2 and C478T in exon 6 of the PPARγ gene, lipids and adipokines in major depression (n = 78) and control subjects (n= 64) were analyzed. Genotypes of PPARy gene polymorphisms were examined. Serum leptin, adiponectin, and resistin were studied by enzyme-linked immunosorbent assay (ELISA). Serum apo A1, apo B, and Lp(a) levels were determined by immunonephelometry. Serum total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol levels were analyzed by enzymatic methods. Results: The genotypes of exon 2 and exon 6 distribution did not differ between the control subjects and patients with major depression. Frequencies of genotypes of Pro12Ala, and Ala12Ala in exon 2 in overweight and obese patients with major depression were higher than those of overweight and obese controls. C478T polymorphism was highest in overweight and obese patients with major depression. Pro12Ala and Ala12Ala genotypes in exon 2 of PPARγ gene in patients were found to be associated with triglyceride and HDL-cholesterol. There were significant differences regarding glucose, total cholesterol, LDL-cholesterol, apo B, Lp(a), adiponectin and resistin levels between patient and control subjects. Conclusion: PPARγ exon gene polymorphisms, alterations in lipid profile and adipokines may be associated with the development of major depression.