Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(11)
- Gül, Abdulkadir(10)
- Baltacı, Cemalettin(9)
- Kaya, Selim(9)
- Kurnaz, Muammer(9)
- Ozturk, Samet(9)
- Çelik, Necati(9)
- Tuncer, Metin(8)
- Altuner, Elif Esra(7)
- Aydin, Aydanur(7)
- Barut, Abdulkadir(7)
- Cin, Aynur(7)
- Günen, Mehmet Akif(7)
- Ozdes, Duygu(7)
- Zaman, Tolga(7)
- Araz, Onur(6)
- Baltaci, Cemalettin(6)
- Bayrakdaroglu, Serdar(6)
- Bozbeyoglu, Pinar(6)
- Demirağ, Hatice(6)
- Karpuz, Ömer(6)
- Liu, Shuxiang(6)
- Merdan, Mehmet(6)
- Yilmaz, Coskun(6)
- Duran, Celal(5)
- Gulcin, Ilhami(5)
- Koçak, Tevfik(5)
- Pala, Fahrettin(5)
- Pilatin, Abdulmuttalip(5)
- Söyler, Mehmet(5)
- Topal, Fevzi(5)
- Tuncer, Gülsüm Zekiye(5)
- Türkkan, Tuğba(5)
- Uysal, Turan(5)
- Yapici, Ismail(5)
- Zengin, Gokhan(5)
- Çam, Alper Veli(5)
- Öztürk, Serkan(5)
- Şan, Murat(5)
- Şimşek, Ahmet Bahadır(5)
Yayınlar
- MakaleYalnız künye2026Scopus SJRQ3Improving conservation breeding: a molecular approach to sex determination in Northern bald ibises (G. eremita)
Yi̇ği̇n, Akin; Bozkaya, Faruk; Gürler, Şükrü; Yılmaz, Bestami; Demi̇rci̇oğlu, İsmai̇l; Yilmaz, Rahşan; Ekti̇ren, Reşat; Ekici, Seda
Introduction: Bald ibises (G. eremita) are migratory birds that have been listed as near extinction by the International Union for Conservation of Nature since 1994 due to a dramatic decline in population size. As this species does not exhibit sexual dimorphism, reliable sex determination requires the use of molecular genetic techniques. The aim of this study was to establish an effective and practical molecular method for sex identification in bald ibises. Materials and methods: The study was conducted on blood and feather samples collected from 96 bald ibises housed at the Şanlıurfa Birecik Bald Ibis Breeding Station. The chromodomain-helicase-DNA-binding (CHD) gene region was amplified by polymerase chain reaction (PCR) using the primer pairs 2550 F–2718R, 1237–1272 H, and P2–P8. PCR products were analyzed by agarose gel electrophoresis. Amplicons obtained with the P2–P8 primer pair were further subjected to restriction fragment length polymorphism (RFLP) analysis using the restriction enzyme HaeIII. In addition, high-resolution melting (HRM) analysis was performed using real-time PCR with primers 1237–1272 H. Results: Following HaeIII digestion of PCR products generated with the P2–P8 primer pair, male individuals exhibited a single band of approximately 350 bp, whereas female individuals showed two bands of approximately 350 and 400 bp. HRM analysis also successfully distinguished sexes based on distinct melting profiles. Both blood- and feather-derived DNA samples were suitable for PCR amplification and subsequent analyses. Conclusion: The results demonstrate that PCR–RFLP analysis using the P2–P8 primer pair combined with HaeIII digestion is a reliable method for sex determination in bald ibises. Furthermore, HRM analysis was applied for the first time in G. eremita and proved to be an effective alternative approach. These molecular methods provide practical and accurate tools for sex identification in conservation and breeding programs of this endangered species.
- MakaleAçık Erişim2026Scopus SJRQ1Towards Greening the BRICS: Uncovering the Impact of Green Energy, Green Technology and Forest Cover on Environmental Quality
Henni, Mohamed Djafar; Ayaydın, Hasan; Akbulut Yıldız, Gizem; Orhan, Abdullah; Pilatin, Abdulmuttalip; Abdelkader, Salim Bourchid
The BRICS economies, facing the threat of climate change, face a policy challenge in transitioning from fossil-fuel-based energy systems and improving environmental quality. This necessitates urgent policy changes in the outdated energy infrastructure of BRICS countries. However, there still remains a policy gap regarding how countries in the BRICS, a group of rapidly developing economies, can grow their economies in line with the Sustainable Development Goals. The aim of our study is to investigate the impact of green energy, green technology, and forest cover on environmental quality in BRICS countries. The BRICS group of countries offers an ideal field of study for both examining the impacts of green energy, green technology, and forest areas on environmental quality in developing economies, as well as for evaluating national and global energy policies. Although numerous studies have empirically examined the relationship between environmental variables and green initiatives, the impact of green initiatives on the load capacity factor has been overlooked. These studies have generally used various econometric methods and have not included machine learning in the process. This study addresses this research gap by focusing on green energy and green technology, which are preferred for their various advantages and make significant contributions to the load capacity factor. To analyze this relationship in BRICS economies between 2000 and 2022, the Augmented Mean Group (AMG) estimator and Machine Learning algorithms were used. According to the results, strong evidence emerges of a positive relationship between green energy, the digital economy, forested area, and the load capacity factor, while a negative relationship exists between green technology, growth, and the load capacity factor. Based on robust empirical findings, renewable energy sources are a key driver of clean energy adoption and can ultimately increase the load capacity factor in BRICS economies. The results also imply that, since developments in green technological innovation in BRICS countries are still in their infancy, investments in green technologies for a sustainable environment need to be qualitatively increased.
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İncele - MakaleYalnız künye2026Scopus SJRQ1Mechanical properties of polypropylene fiber-reinforced shotcrete based chromite flotation waste using a nondestructive testing method
Aksüt, Yavuz Selim; Seferoğlu, Mehmet Tevfik
This study examines the mechanical behavior and non-destructive assessment of shotcrete reinforced with polypropylene fibers (PPFs) and incorporating chromite flotation waste (CFW) as a partial substitute for fine aggregate. Shotcrete mixtures were prepared with four CFW replacement levels (0–30%) and four PPFs volume fractions (0–1%) and their compressive strength, splitting tensile strength and static modulus of elasticity were evaluated. Poisson's ratio and ultrasonic pulse velocity (UPV) were experimentally determined. The effect of fiber reinforcement and waste incorporation on the mechanical behavior was evaluated through statistical correlation, simple regression and multivariable predictive modeling approaches. The results showed that moderate PPFs contents (0.25–0.5%) generally enhanced compressive and tensile performance while excessive fiber dosage (1%) led to strength and stiffness reductions due to increased heterogeneity, fiber agglomeration and void formation at high CFW replacement levels. Increasing CFW content resulted in systematic reductions in UPV values with an average decrease of approximately 3–4% per 10% CFW replacement indicating changes in matrix continuity and internal structure. However, these UPV reductions were not directly proportional to losses in mechanical strength or elastic stiffness. Correlation analyses revealed weak to moderate relationships between UPV and mechanical properties confirming that UPV alone is insufficient to represent the complex behavior of fiber-reinforced, waste-based shotcrete systems. Simple UPV-based regression models exhibited limited predictive capability for both compressive strength (R2 ~ 0.16) and static modulus of elasticity (R2 ~ 0.002). In contrast, multivariable regression models incorporating normalized UPV, CFW replacement ratio and PPFs volume fraction together with their interaction terms, significantly improved prediction accuracy. The proposed models achieved high coefficients of determination (R2 ~ 0.86 for compressive strength and R2 ~ 0.97 for static elastic modulus) with substantially reduced root mean square error (RMSE) values. Finally, the findings demonstrate that UPV can be effectively used as a non-destructive indicator for estimating the strength and stiffness of PPFs reinforced shotcrete incorporating CFW only when material specific parameters are explicitly considered.
- MakaleAçık Erişim2026Scopus SJRQ3In-depth Analysis of the Control Unit for Multiple Voltage Rails to Drive a Variety of ICs
Yanarateş, Cağfer; Altan, Aytaç
Generating a negative output voltage rail from a positive input voltage is possible by reconfiguring an ordinary buck regulator into an inverting buck-boost (IBB) topology. Rather than operating considerations such as voltage and current stresses, the main challenge associated with this transformation arises from differences in the small-signal closed-loop characteristics. The most critical distinction is the presence of a right-half-plane (RHP) zero in the control-to-output transfer function of the IBB, which introduces non-minimum-phase behaviour, reduces the achievable phase margin, and may lead to instability and poor load transient response. For conventional PI controllers, the buck and IBB converters resulted in settling times of 5.0 ms and 6.8 ms, with overshoots of 13.65% and 8.46%, respectively, thus demonstrating the performance limitations of fixed-gain designs. As a solution, an auto-tuned PI controller with adaptive features has been proposed, which operates effectively in both the buck and IBB topologies. The proposed scheme achieves a significantly faster settling time of 2.27 ms with overshoot and undershoot below 2%, thereby ensuring superior robustness and dynamic performance compared to conventional approaches.
AtıfScopus2WoS2İncele - MakaleYalnız künye2026Scopus SJRQ2The effect of self-selected soothing music on fistula puncture-related pain and comfort levels in hemodialysis patients: a randomized controlled, single-blind, single-center study
Sayilan, Samet; Sayilan, Aylin Aydin; Kulakac, Nursen
Purpose: To investigate the effect of music therapy on pain and comfort levels in hemodialysis patients. Methods: The study was completed with 30 experimental patients and a 30-member control group receiving treatment in the hemodialysis unit in a hospital in Western Türkiye. Experimental group patients were allowed to listen to a form of music selected by them for approximately 6 min prior to each procedure. No procedure was performed on the members of the control group. A Visual Analog Scale (VAS) was applied in sessions 1, 6, and 12, and the Hemodialysis Comfort Scale in sessions 1 and 12. The independent sample t test and repeated-measures analysis of variance were employed in data analysis, and Cohen’s d in effect size calculations. Results: Hemodialysis Comfort Scale scores were significantly higher at the end of the study in the experimental group compared to the control group (SMD: 3.54, 95% CI 2.33–4.75) (p < 0.05). Mean VAS scores were significantly lower among the experimental group compared to the control group at the second (6th session) (SMD: 1.94, 95% CI 1.34–2.54) (p < 0.001) and third (12th session) evaluations (SMD: 3.2, 95% CI 1.2.65–3.75) (p < 0.001). VAS scores were also significantly lower in the experimental group at the third evaluation compared to the earlier evaluations (p < 0.05). Conclusion: The patients in the experimental group listened to a form of music of their choice before 12 hemodialysis sessions. Music was found to exhibit a positive effect on pain and discomfort in patients receiving hemodialysis. Trial registration: NCT05574595.
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İncele - MakaleAçık Erişim2026Scopus SJRQ1Pyrolysis-based valorization of Pinus sylvestris bark waste into bioactive fractions: LC–MS/MS analysis and antioxidant, anti-inflammatory, antidiabetic, and antibacterial activities
Gül, Abdulkadir
In this study, bark waste from the forest industry derived from Pinus sylvestris was processed by pyrolysis extraction, and the chemical compositions and biological activities of the resulting light (PLF) and heavy (PHF) fractions were comparatively investigated. When the extraction yields of the pyrolysis fractions were compared, PHF (20.80%) showed a significantly higher recovery than PLF (10.35%). Total phenolic content (TPC) was higher in the PHF (365.80 GAE/g), whereas total flavonoid content (TFC) was concentrated in the PLF (200.80 mg QE/g). LC–MS/MS analyses of the PHF fraction, which exhibited more pronounced biological activity, revealed caffeic acid (7190.65 µg/g) and protocatechuic acid (2694.30 µg/g) as the predominant phenolic compounds. Antioxidant capacity analyses indicated that the PLF exhibited stronger radical scavenging activity, lower IC50 values in DPPH and ABTS⁺• assays (50.01 and 101.60 µg/mL, respectively) and higher TAC values (901.00 mg TE/L). Fe3+ and Cu2+ reducing assays demonstrated strong redox activity in both fractions, with Cu2+ reducing capacity particularly higher in PLF. In enzyme inhibition studies, the PHF showed stronger inhibition against 5-lipoxygenase (IC50 = 29.28 µg/mL) and α-glucosidase (IC50 = 82.50 µg/mL) compared to PLF. The antibacterial potential of the fractions was assessed using Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, Salmonella typhimurium, and Klebsiella pneumoniae. The PHF exhibited significant inhibition zones, particularly against P. aeruginosa (17.40 mm) and S. aureus (13.40 mm). Consequently, these findings suggest that pyrolysis-based fractionation may be an effective and sustainable method for converting P. sylvestris bark waste into functional fractions with high antioxidant, anti-inflammatory, antidiabetic, and antibacterial potential.
AtıfScopus2WoS2OpenAlex2İncele - MakaleYalnız künye2026Scopus SJRQ3Integrative taxonomy describes a new species of the genus Dicranolasma Sørensen (Opiliones: Dicranolasmatidae) from Turkey
Kurt, Kemal; Kurt, Pınar
A new species, Dicranolasma gumushanensissp. n., is described from the Gümüşhane Province of the northeastern region of Turkey, based on morphological and genetic evidence. The newly described species differs from similar species within the genus, particularly due to morphological characteristics such as the structure of the chelicerae and genitalia, and its molecular characteristics. A detailed description and diagnostic characteristics of the new species are provided, in addition to images of its body in dorsal view, chelicerae, pedipalps and genitalia. The nuclear (28S rRNA) and mitochondrial (COI) gene regions of the species were sequenced, revealing its phylogenetic relationships within the genus Dicranolasma. http://www.zoobank.org/urn:lsid:zoobank.org:pub:1C3512F0-4ED4-4B60-A0FC-65EF62173573.
- MakaleYalnız künye2026Scopus SJRQ1Radio frequency heating of whole peanuts for microbial safety and quality preservation using interlayer displacement under stationary and moving conditions: Effects of salt coating and natural skin on heating behavior
Kahraman, Kubra; Tasci, Caner; Cakir, Elif Nida; Liu, Shuxiang; Soncu, Eda Demirok; Erdogdu, Ferruh; Ozturk, Samet
This study aimed to improve the efficiency of a radio frequency (RF) heating system for pasteurizing whole peanuts while maintaining quality attributes using a stationary position or continuous movement. Heating efficiency was evaluated using commercially available roasted whole peanuts: salt-coated skin-on, unsalted skin-on, and unsalted peeled peanuts. To improve heating uniformity and ensure sufficient microbial inactivation of Salmonella enterica serovar Enteritidis PT30, a single interlayer-displacement strategy was applied in both stationary and continuous modes. Quality attributes including protein structure and fatty-acid profiles were assessed under the selected RF processing conditions. The RF system equipped with a conveyor belt was used to process peeled, unsalted peanuts inoculated with S. Enteritidis PT30 at approximately 7.9–8.5 log CFU/g. The three commercial peanut types exhibited differences in RF temperature distribution and heating uniformity, with salt-coated skin-on peanuts showing higher average temperature than unsalted peeled samples under the evaluated conditions. Continuous movement increased average temperature by approximately 10 °C but resulted in poorer heating uniformity, with a 3 °C higher standard deviation (SD). A single interlayer-displacement (overturning) step improved heating uniformity. This step increased Salmonella reductions from 3.41 to 4.77 log CFU/g under stationary processing and from 2.92 to 4.22 log CFU/g under continuous processing after 60 min of RF heating. The evaluated protein and lipid quality characteristics of unsalted peeled peanuts remained largely unchanged following RF processing. Overall, these findings demonstrated the potential of RF heating combined with interlayer displacement for microbial decontamination of unsalted peeled whole peanuts while maintaining the quality attributes evaluated in this study.
- MakaleYalnız künye2026Scopus SJRQ2Radiation shielding performance and microstructural characterization of Al–Cu-Sc/B4C nanocomposites
Şirin, Murat; Kaya, Selim; Temiz, Cengiz; Çağlar, Seyit
This study investigates the gamma-ray and fast-neutron shielding performance of Al–Cu–Sc/B4C nanocomposites containing 0–20 wt% boron carbide (B4C). The composites were produced using melt spinning, high-energy ball milling, and vacuum sintering techniques. Their structural and microstructural characteristics were examined by X-ray diffraction and scanning electron microscopy. Gamma-ray attenuation properties were measured experimentally at photon energies of 0.662, 1.173, and 1.333 MeV using a high-purity germanium detector. In addition, theoretical calculations were carried out in the 0.05–2.50 MeV energy range using Monte Carlo simulations together with the Phy-X/PSD calculation platform. Several radiation shielding parameters were evaluated, including the mass attenuation coefficient, half-value layer, mean free path, radiation protection efficiency, effective atomic number, and fast-neutron removal cross-section. The results show that the incorporation of B4C improves the fast-neutron shielding capability of the composites. The sample containing 20 wt% B4C exhibits an increase of approximately 32% in fast-neutron removal cross-section compared with the reference alloy. A slight reduction in gamma-ray attenuation is observed at low photon energy, whereas the shielding performance at medium and high energies remains nearly unchanged. These findings indicate that Al–Cu–Sc/B4C nanocomposites are promising lightweight and lead-free candidates for shielding against mixed gamma and neutron radiation. Their low density and the absence of toxic lead support potential applications in medical radiation facilities, nuclear technology systems, aerospace platforms, and industrial radiation environments where both radiation protection and weight reduction are important.
AtıfScopus7WoS7OpenAlex6İncele - MakaleYalnız künye2026Scopus SJRQ1Blue-Shift Effect-Based Positioning for Multi-Color VLC
Kucuk, Mehmet Ali; Turk, Kadir
In this letter, an angle-of-arrival (AoA)-based integrated positioning system is proposed that utilizes the standard optical front-end of multi-color visible light communication (MC-VLC). Unlike traditional AoA methods, which rely on specialized receiver architectures, the proposed approach uses the inherent angular dependence of optical filter transmission responses, known as the blue-shift effect, for directly estimating the angle of incidence from the received signal. In this context, an AoA estimation technique is developed by combining eigenvalue decomposition of the MC-VLC channel with regression analysis. Simulation results show that the proposed system achieves millimeter-level positioning accuracy, enabling robust and high-precision indoor localization without additional hardware complexity or cost.
AtıfScopus2OpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ1When grief persists online: Development of the Digital Prolonged Grief Severity Scale
Çınar, Öznur; Cengiz, Ekrem
Bereaved individuals encounter the deceased through social media profiles, message histories, and algorithmic reminders, yet no validated instrument measures prolonged grief expressed through digital interactions. We developed and validated a multidimensional measure of digital-environment prolonged grief severity (DPGSS). Turkish bereaved adults (n = 577) bereaved at least 12 months earlier completed the DPGSS alongside grief, distress, and other less relevant measures, and 125 completed it again about three weeks later. Factor analyses supported a four-factor structure—digital separation distress and preoccupation, digital emotional responses, digital avoidance, and digital functional impairment—in 15 items. The correlated four-factor model fit the data well, outperforming a one-factor alternative. The DPGSS demonstrated strong internal consistency, test-retest reliability, and measurement invariance across nine demographic variables. Convergent associations with grief and distress, and negligible associations with rigidity and AI acceptance, supported its construct specificity. The DPGSS-15 is a reasonable tool for assessing digital prolonged grief.
- MakaleAçık Erişim2026Scopus SJRQ1Semi-experimental approach for hydrogen storage of as-produced zeolitic imidazolate framework-8 without post-processing
Öztürk, Banu; Asan, Abdurrahman; Köse, Dursun Ali; Kalkişim, Ahmet Tahir; Öztürk, Zeynel
Low-cost hydrogen storage systems are essential for the widespread use of hydrogen, particularly in mobile platforms such as unmanned aerial vehicles, to increase their range. Hydrogen storage in metal–organic frameworks (MOFs), which offer high capacity through adsorption, is crucial to achieving this goal. This study investigates the hydrogen storage capacity of zeolitic imidazolate framework-8 (ZIF-8), produced via reactive extrusion, which allows for high production capacity and low-cost manufacturing of MOFs. Furthermore, particular attention was given to the storage capacity of ZIF-8 in its as-produced form. An atomistic model of the as-produced ZIF-8, including impurities selected from a series of simulated models containing different amounts of impurity, was developed. The validity of the selected structure was then verified through experimental powder X-ray diffraction and Brunauer–Emmett–Teller (BET) surface area measurements. Subsequently, hydrogen adsorption capacities for varying pressures and temperatures were calculated. The hydrogen adsorption simulations indicated that the atomistic model of the as-produced ZIF-8 exhibited a hydrogen storage capacity of 1.76 wt.% at 77 K and 1 bar, corresponding to a BET surface area of 516 m2/g. In comparison, the experimentally synthesized as-produced ZIF-8 showed a capacity of 1.145 wt.% under the same conditions, with a BET surface area of 520 m2/g. The study demonstrates that the gas storage performance of experimentally produced structures, even without further purification, can be accurately determined through simulation models in this semi-experimental study.
- MakaleAçık Erişim2026Scopus SJRQ4Assessment of the effect of conventional and contemporary drying methods on the phenolic profile modulation and antioxidant retention of Trabzon persimmon (Diospyros kaki L.)
Koçak, Tevfik; Demirel Ozbek, Yagmur; Saral, Ozlem; Kocyigit, Emine
This study investigated the effects of conventional and modern drying methods on the total phenolic content, antioxidant activity, and phenolic compound composition of Trabzon persimmons (Diospyros kaki L.) fruits harvested from the same tree and at comparable maturity stages were subjected to sun drying, shade drying, oven drying, air-fryer drying, and microwave drying techniques, with raw samples serving as the control group. The total phenolic content was assessed via the Folin–Ciocalteu method, and the antioxidant capacity was evaluated using the ferric reducing antioxidant power (FRAP) and DPPH radical scavenging activity assays. The identification and quantification of phenolic compounds were conducted using the HPLC technique. The results indicated that the drying process produced statistically significant variations in the phenolic content and antioxidant capacity of Trabzon persimmons. The microwave drying technique resulted in highest total phenolic content and antioxidant activity, whereas both sun and shade drying procedures showed higher values than raw samples. The total phenolic content and antioxidant capacity of samples dried in an air fryer were found to be comparable to those of raw samples. The profile of phenolic compounds varied according to the drying process employed; certain compounds exhibited an increase with specific methods, while others were identified solely under particular conditions. Thus, it has been shown that drying techniques can have a significant impact on preserving and improving the functional properties of persimmons. Furthermore, we believe that microwave drying could be an effective alternative, particularly in terms of preserving bioactive compounds.
AtıfScopus1OpenAlex1
İncele - MakaleYalnız künye2026Scopus SJRQ1A logarithmic-type estimator for finite population variance and its efficiency properties
Iftikhar, Soofia; Alamgir; Zaman, Tolga
This study proposes a novel logarithmic-type estimator for the finite population variance. We derive the mean square error (MSE) expressions, approximated to the first order, along with the associated efficiency conditions for the proposed estimator, as well as for several existing estimators from the literature. A comprehensive simulation study is conducted to compare the efficiency of the new estimator against these established methods. Based on the analysis of a real dataset, the results demonstrate that the proposed estimator achieves the minimum mean square error and satisfies all relevant efficiency criteria. Consequently, it is concluded that the proposed estimator outperforms the other considered estimators in terms of efficiency.
- MakaleYayıncıda açık erişim2026Scopus SJRQ4A data-driven decision-support framework for prioritizing retention interventions among high attrition-risk employee segments
Şimşek, Tuğçe; Şimşek, Aybala
Predicting employee attrition risk provides a useful signal for human resource decision-making. However, this signal alone does not determine which employee groups should be targeted first for retention interventions. This study develops a data-driven decision-support framework for prioritizing retention interventions among employees at risk of attrition. The framework uses the IBM HR Analytics Employee Attrition and Performance dataset and integrates calibrated machine learning, SHAP-based explanatory analysis, Entropy-CRITIC weighting, and PROMETHEE II ranking. Machine-learning models were first used to estimate employee-level attrition probabilities. These probabilities were then aggregated into segments defined by combinations of Department, JobRole, and OverTime, from which the high-risk segment pool was identified for multi-criteria analysis. Eight high-risk segments were detected. The segment ranked first by PROMETHEE II was not the segment with the highest attrition risk, indicating that intervention priority and attrition risk represent distinct decision outputs. Sensitivity analyses further showed that the segment-ranking structure remained stable under alternative weight-shift and threshold scenarios. The proposed framework is therefore not intended to identify individual employees at risk; rather, it supports transparent, auditable, and ethically compliant segment-level retention decisions.
- MakaleYalnız künye2026Scopus SJRQ1A multi-scale context-aware deep learning framework for medical disease diagnosis
Reis, Hatice Catal; Turk, Veysel
Early and accurate diagnosis of brain tumors, skin lesions, and diabetic retinopathy is essential for effective treatment planning and improving patient prognosis. Nevertheless, the diagnostic process for these conditions remains challenging due to the reliance on conventional methods, which are often subjective, time-intensive, and dependent on expert interpretation. In this context, deep learning-based approaches offer promising opportunities to enhance diagnostic precision and support clinical decision-making. This study introduces BSCRADNet, a novel deep learning model designed for the automated diagnosis of oncological and retinopathic diseases. The proposed architecture employs a multi-layered analytical framework that integrates local and spatial features with long-range contextual dependencies, enabling the effective recognition of complex morphological patterns in medical images. By enhancing diagnostic consistency, BSCRADNet reduces the risk of misclassification—particularly in cases characterized by high inter-observer variability or subtle lesion presentation. The model demonstrated strong performance across multiple datasets, achieving classification accuracies of 94.67% for brain tumors, 89.58% for skin cancer, and 90.40% for diabetic retinopathy. Furthermore, to improve the discriminative power of feature representations across diverse disease categories, a composite hybrid architecture combining BSCRADNet with ResMLP was developed. This hybrid model yielded competitive results, with accuracies of 93.33%, 88.19%, and 87.40% for the respective diagnostic tasks. Experimental findings indicate that the proposed approach is capable of distinguishing intricate patterns in medical imaging data and holds significant potential for integration into clinical diagnostic workflows, contributing to more reliable and efficient disease classification.
AtıfScopus1WoS1OpenAlex1İncele - MakaleYalnız künye2026Scopus SJRQ3New and noteworthy liverwort records for Türkiye and South-West Asia
Erata, Hüseyin; Batan, Nevzat; Mamontov, Yuriy S.; Özdemir, Turan
The liverwort taxa Cephaloziella elegans and Mesoptychia gillmanii are reported for the first time from Türkiye and Southwest Asia, based on a bryological field trip to the Karçal Mountains in the Caucasian region (Artvin). Additionally, Lophoziopsis excisa is recorded for the second time in Türkiye, with the newly discovered locality extending the known national distributions of this taxon. Descriptions, illustrations, data on world distribution and ecology, as well as comparisons with morphologically similar species, are provided.
AtıfOpenAlex4İncele - MakaleYalnız künye2026Scopus SJRQ1Nutritional value, heavy metal contamination and health risk assessment of Phalangium opilio Linnaeus, 1758 as a potential edible arachnid
Gürmeriç, Hüseyin Ender; Kurt, Pınar; Ürkek, Bayram
Edible insects and arachnids have increasingly been recognised as alternative food sources. The aim of the study was to evaluate the harvestman species Phalangium opilio (P. opilio) Linnaeus, 1758 as a new edible species. In this research, some chemical properties, fatty acid and mineral composition of the P. opilio were investigated. Additionally, the heavy metal contamination and its health risk assessment were evaluated. The fat and protein contents of the samples were 1.18% and 14.07%, respectively. The P. opilio had unsaturated fatty acids such as myristoleic, palmitoleic, linoleic and oleic acids. The P. opilio was analyzed for K, Mg, Na, Ca, Fe, Zn, Al, Mn, Se contents, estimated daily intake and contributions to the recommended daily mineral intake were calculated. The heavy metals detected in the P. opilio were Cu, Ni, Cd, Pb, As, Cr, Co and Ag. The Cd had the highest target hazard quotient value (2.16). The hazard index value of the P. opilio was 3.32 and it had a potential health risk level. Consequently, although P. opilio exhibited favourable nutritional properties, the THQ value for Cd and the cumulative HI value exceeded the recommended safety threshold, indicating a potential non-carcinogenic health risk associated with its consumption. Accordingly, considering the detected heavy metal levels and associated health risk indices, the consumption of wild-collected P. opilio should be approached with caution. © Hüseyin Ender Gürmeriç et al., 2026. Published with license by Koninklijke Brill BV. This work is published by Koninklijke Brill BV. Koninklijke Brill bv incorporates the imprints Brill, Brill Nijhoff, Brill Schöningh, Brill Fink, Brill mentis, Brill Wageningen Academic, Vandenhoeck & Ruprecht, Böhlau and V&R unipress. Koninklijke Brill BV reserves the right to protect the publication against unauthorized use and to authorize dissemination by means of offprints, legitimate photocopies, microform editions, reprints, translations, and secondary information sources, such as abstracting and indexing services including databases. Requests for commercial re-use, use of parts of the publication, and/or translations must be addressed to Koninklijke Brill BV.
- MakaleYalnız künye2026Scopus SJRQ2Novel 1,2,4-triazole-based n-mannich derivatives: Synthesis, spectroscopic characterization, cytotoxic, antimicrobial, and enzyme inhibitory activities, and in silico studies
Yılmaz, Yonca; Medetalibeyoğlu, Hilal; Kapancık, Serkan; Tüzün, Burak; Lukšič, Miha; Aslan, Rukiye; Topal, Fevzi; Kocyigit, Umit M.; Yüksek, Haydar; Harmankaya, Ahmet
A series of novel 1,2,4-triazole-based Mannich bases was designed, synthesized, and evaluated for biological and theoretical properties. Schiff base intermediates (C1–6) were prepared by condensing 4-benzoxy-3-methoxybenzaldehyde with various 3-substituted-4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones. Mannich reactions with formaldehyde and 2,6-dimethylmorpholine produced six target compounds (D1–6). Structures were confirmed using spectroscopic techniques. Following structural confirmation, the compounds showed significant cytotoxicity against HT-29 and MCF-7 cancer cell lines in MTT assays. Enzyme inhibition studies demonstrated activity against glucose-6-phosphate dehydrogenase (G6PDH) and lactate dehydrogenase (LDH), indicating potential relevance to cancer metabolism. Moderate acetylcholinesterase inhibition was observed, with IC50 values from 56.81 to 182.40 µM. Antimicrobial testing showed that D1, D3, D4, and D5 were active against selected microbial strains, while D2 and D6 were inactive. Density functional theory (DFT) calculations, molecular docking, ADME/T predictions, and molecular mechanics simulations were conducted to complement the experimental findings. These computational analyses indicated favorable binding interactions and pharmacological profiles.In summary, the newly synthesized triazole-based Mannich derivatives represent promising candidates for further pharmacological investigation.
AtıfOpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ2Effects of transcutaneous auricular vagus nerve stimulation added to robotic rehabilitation in patients with ischemic stroke: a randomized clinical trial
Kızıl, Ömer Dicle; Ural, İbrahim Halil; Hatık, Sefa Haktan; Özden, Ali Veysel; Aydın, Emine Büşra
Background: This study aimed to investigate the effects of adding transcutaneous auricular vagus nerve stimulation (taVNS) to robotic rehabilitation on functional outcomes and neuromuscular activity in patients with ischemic stroke. Methods: This randomized controlled clinical trial employed a pre–post study design and was conducted in a hospital-based physiotherapy and rehabilitation clinic. A total of 40 patients with ischemic stroke, aged 18–65 years, were randomly assigned to either a robotic rehabilitation group (RRG) or a combined vagus nerve stimulation and robotic rehabilitation group (VRRG). Spasticity, walking speed, motor function, quality of life, muscle activity, and pain were assessed at baseline and after six weeks of treatment. Results: Primary outcome measures were walking speed, motor function assessed by the Fugl–Meyer Assessment, and pain intensity. Secondary outcomes included electrophysiological measurements (H-reflex and F-wave parameters) and quality of life. Within-group analyses showed significant improvements in all outcomes in the VRRG (p < 0.05), whereas all outcomes except pain improved significantly in the RRG (p < 0.05). Between-group comparisons demonstrated greater improvements in walking speed in the VRRG compared with the RRG (mean difference − 1.84 s, 95% CI − 3.7 to − 0.7; r = 0.43; p = 0.006) and greater pain reduction in the VRRG (mean difference − 1.55, 95% CI − 2.5 to − 0.1; r = 0.30; p = 0.048). In contrast, a greater reduction in the Hmax/Mmax amplitude ratio—an electrophysiological marker of spinal excitability—was observed in the RRG. Conclusion: The findings suggest that transcutaneous auricular vagus nerve stimulation combined with robotic rehabilitation may provide additional benefits in terms of walking speed and pain reduction in patients with ischemic stroke. Trial registration: The study was registered at ClinicalTrials.gov on April 19, 2024. (Identifier: NCT06381089).