Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(64)
- Merdan, Mehmet(47)
- Baltaci, Cemalettin(35)
- Kulakaç, Nurşen(28)
- Duran, Celal(27)
- Ozdes, Duygu(24)
- Turan, Ibrahim(24)
- Demir, Selim(23)
- Türkkan, Tuğba(22)
- Bayrakdaroglu, Serdar(21)
- Topal, Fevzi(21)
- Öztürk, Serkan(21)
- Ürkek, Bayram(21)
- Gücer, Mehmet Ali(20)
- Akar, Zeynep(19)
- Kaygusuz, Abdullah(19)
- Topal, Meryem(19)
- Anaç, Halil(18)
- Aydin, Aydanur(18)
- Batan, Nevzat(18)
- Erata, Hüseyin(18)
- Tuncer, Metin(18)
- Akyürek, Suat(17)
- Baltacı, Cemalettin(17)
- Karimullah, Suud Sarim(17)
- Acet, Tuba(16)
- Akar, Bülent(16)
- Ashyralyyev, Charyyar(16)
- Düzgün, Azer Özad(16)
- Hintistan, Sevilay(16)
- Yılmaz, Coşkun(16)
- Aliyazicioglu, Yuksel(15)
- Kaya, Hacer(15)
- Kurnaz, Muammer(15)
- Kurt, Kemal(15)
- Ozden, Talat(15)
- Yilmaz, Coskun(15)
- Yuksel, Ferhat(15)
- Yücel, Cem(15)
- Öz, Mehmet(15)
Yayınlar
- MakaleAçık Erişim2017Scopus SJRQ3Effects of fine aggregate abrasion resistance and its fineness module on wear resistance of Portland cement concrete pavements
Karpuz, Orhan; Akpinar, Muhammet Vefa; Aydin, Metin Mutlu
In this research, effects of fine aggregate abrasion resistance and its fineness module on wear resistance of Portland cement concrete pavements studied. Concrete samples included fine crushed limestone aggregate, fine crushed limestone-basalt mixture, and fine crushed basalt aggregate. The study results showed that LA abrasion rate of 30 % or less of fine aggregates would be necessary for long lasting concrete roads. Furthermore, it was found that fine aggregate's fineness module of 3.15 will significantly increase concrete road surface's wear resistance. As the fine aggregate's fineness module value increased from 2.2 to 3.15, the concrete's wear amount decreased to 15.5 %. Study findings also showed that using basalt aggregates instead of widely used limestone aggregates, will significantly increase pavement concrete wear resistance.
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İncele - MakaleAçık Erişim2017Scopus SJRQ1Novel eugenol derivatives: Potent acetylcholinesterase and carbonic anhydrase inhibitors
Topal, Fevzi; Gulcin, Ilhami; Dastan, Arif; Guney, Murat
Eugenol was used as starting material to obtain some phenolic compounds. The synthesis of these phenolic compounds was performed in a two-step procedure. The structures of the formed products (novel eugenol derivatives 1–6) have been determined on the basis of NMR spectroscopy and other spectroscopic methods. The compounds were tested in terms of carbonic anhydrase (CA) inhibition potency. Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes, which catalyse the reaction between carbon dioxide (CO2) and water (H2O), to generate bicarbonate (HCO3−) and protons (H+). CO2, HCO3− and H+ are essential molecules and ions for many important physiologic processes occurring in all living organisms. Acetylcholinesterase (AChE, E.C.3.1.1.7) is found in high concentrations in the red blood cells and brain. Novel eugenol derivatives (1–6) were tested for the inhibition of two cytosolic CA isoforms I, and II (hCA I, and II) and AChE. These compounds demonstrated effective inhibitory profiles with Ki values in ranging of 113.48-738.69 nM against hCA I, 92.35-530.81 nM against hCA II, and 90.10-379.57 nM against AChE, respectively. On the other hand, acetazolamide clinically used as CA inhibitor, shoed Ki value of 594.11 nM against hCA I, and 120.68 nM against hCA II, respectively. Also, AChE was inhibited by tacrine as an AChE inhibitor at the 71.18 nM level.
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İncele - BildiriAçık Erişim2017Scopus SJRQ3Gold and silver content of plant Helichrysum arenarium, popularly known as the golden flower, growing in Gümüşhane, NE Turkey
Vural, A.
Geochemical and biogeochemical methods in mineral exploration have been widely used in recent years because of the depletion of known deposits and the need to explore buried deposits. The aim of this study was to investigate the gold and silver content of Helichrysum arenarium, popularly known as the golden flower, for possible exploration of precious ore deposits. For this purpose, plant samples of the respective plant parts (roots, stem-leaves and flowers) collected from Demirören village of Gümüşhane in the northeastern Turkey were analysed for gold and silver by using inductively coupled plasma mass spectrometry. Gold and silver contents of the plants was assessed on the basis of different statistical approaches. The results indicate that the plant has elevated levels of gold and silver concentrations, particularly in the case of gold. As a result, it was determined that the gold content of Helichrysum arenarium is remarkable and the gold accumulation capacity of the plant is high in the the stem-leaves, whereas the silver accumulation capacity of the plant is high in roots.
AtıfScopus12WoS8OpenAlex10İncele - MakaleAçık Erişim2017Scopus SJRQ1Diversity and genetic analysis through DArTseq in common bean (Phaseolus vulgaris L.) germplasm from Turkey
Nemlı, Seda; Kaygisiz Aşçioğul, Tansel; Ateş, Duygu; Eşıyok, Dursun; Tanyolaç, Muhammed Bahattin
The common bean (Phaseolus vulgaris L.) is the most consumed food legume in the world and is a major source of dietary protein, carbohydrates, and valuable micronutrients, especially in developing countries. Diversity Arrays Technology (DArTseq), based on genome reduction with restriction enzymes, provides a rapid, high-throughput, and cost-effective tool capable of generating thousands of genotyped single nucleotide polymorphisms (SNPs) for a genome-wide analysis of genetic diversity. In this study, we aimed to characterize common bean accessions using SNPs detected by a DArTseq approach. A total of 43,018 SNPs were identified from 173 common bean accessions, including Andean and Mesoamerican genotypes. After filtering raw and redundant data, a total of 16,366 SNPs were considered for further analyses. According to population structure analysis, the genotypes were roughly divided into 2 gene pools of Andean and Mesoamerican types. Pairwise fixation index (Fst) values were calculated to resolve the differentiation between populations. This study demonstrated that discovering SNPs from the whole genome is a potential resource for identifying naturally diverse accessions and also the information could be used in breeding programs to develop new common bean varieties.
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İncele - MakaleAçık Erişim2017Scopus SJRQ1Production of deep-fried corn chips using stale bread powder: Effect of frying time, temperature and concentration
Yuksel, Ferhat; Karaman, Safa; Gurbuz, Melek; Hayta, Mehmet; Yalcin, Hasan; Dogan, Mahmut; Kayacier, Ahmed
In this study, utilization of stale bread powder was evaluated to produce low fat snack food formulation and for this purpose, corn chips were manufactured using stale bread at different concentrations. Response surface modeling technique was used to study the simultaneous effects of stale bread level (0–50%), frying time (40–60 s) and frying temperature (170–190 °C) on some physicochemical, textural and sensory properties of corn chips enriched with stale bread powder. Also, optimization of processing variables was performed for desired products. Results indicated that the addition of stale bread into the formulation decreased the oil content of the final product up to addition of 25% stale bread level. The hardness and yellowness of samples decreased with the increasing of stale bread level; while, the dry matter and ash contents as well as firmness value and sensory scores of samples increased with the increasing stale bread level. Generally, corn chips produced with the addition of stale bread were more preferred by the panel compared to control samples.
AtıfScopus20WoS17OpenAlex22İncele - MakaleAçık Erişim2017Scopus SJRQ2Solution of conformable fractional ordinary differential equations via differential transform method
Ünal, Emrah; Gökdoğan, Ahmet
Recently, a new fractional derivative called the conformable fractional derivative is given which is based on the basic limit definition of the derivative in (Khalil et al., 2014). Then, the fractional versions of chain rules, exponential functions, Gronwall's inequality, integration by parts, Taylor power series expansions is developed in (Abdeljawad, 2015). In this paper, we give conformable fractional differential transform method and its application to conformable fractional differential equations.
AtıfScopus134WoS116OpenAlex140İncele - MakaleAçık Erişim2017Scopus SJRQ2Prevalence and comparing of some microbiological properties, somatic cell count and antibiotic residue of organic and conventional raw milk produced in Turkey
Ürkek, Bayram; Şengül, Mustafa; Erkaya, Tuba; Aksakal, Vecihi
The aim of this study was to investigate the effects of production systems and milk collection periods on the somatic cell count (SCC), some microbiological properties, total aerobic mesophilic bacteria (TAMB), coliform, Staphylococcus aureus (S. aureus), yeast and mould) and antibiotic residue of milk; in Turkey. Milk samples were collected from 9 conventional farms and 9 organic farms during one year time, at six different months (December 2013 to October 2014), and all farms were selected from the same geographical locations. All organically managed farms had organic production certificates given by the Republic of Turkey Ministry of Food, Agriculture and Livestock. The count of TAMB, coliform, and coagulase positive S. aureus were affected by production systems at the level of p<0.01; yeast and mold, and somatic cell count (SCC) were affected at the level of p<0.05. But, differences according to months were statistically significant only on TAMB (p<0.01) and coliform (p<0.05) counts. The general means of TAMB, coliform and yeast and mould counts of the organic milk (OM) were significantly lower (p<0.05), while the general means of SCC and coagulase positive S. aureus count of the OM was significantly higher (p<0.05) compared to conventional milk (CM). Antibiotic residue was determined in one of the CM sample and in two of the OM samples. Our study is the first research that compared conventional and organic milk in Turkey. This study indicated that the microbiological quality of OM was the higher in terms of TAMB, coliform and yeast and mould, whereas was the lower in relation to SCC and coagulase positive S. aureus counts. But, the quality of both milk types should be improved.
AtıfScopus10WoS8OpenAlex12İncele - MakaleAçık Erişim2017Scopus SJRQ2Synthesis of imine bond containing insoluble polymeric ligand and its transition metal complexes, structural characterization and catalytic activity on esterification reaction
Gönül, İlyas; Ay, Burak; Karaca, Serkan; Saribiyik, Oguz Yunus; Yildiz, Emel; Serin, Selahattin
In this study, synthesis of insoluble polymeric ligand (L) and its transition metal complexes [Cu(L) Cl2]·2H2O (1), [Co(L)Cl2(H2O)2] (2) and [Ni(L)Cl2(H2O)2] (3), having the azomethine groups, were synthesized by the condensation reactions of the diamines and dialdehydes. The structural properties were characterized by the analytical and spectroscopic methods using by elemental analysis, Fourier Transform Infrared, Thermo Gravimetric Analysis, Powder X-ray Diffraction, magnetic susceptibility and Inductively Coupled Plasma. The solubilities of the synthesized polymeric materials were also investigated and found as insoluble some organic and inorganic solvents. Additionally, their catalytic performance was carried out for the esterification reaction of acetic acid and butyl acetate. The highest conversion rate is 75.75% by using catalyst 1. The esterification of butanol gave butyl acetate with 100% selectivity.
AtıfScopus4WoS4OpenAlex7İncele - MakaleAçık Erişim2017Scopus SJRQ3A fourth order approximation of the neumann type overdetermined elliptic problem
Ashyralyyev, Charyyar
In this paper, we consider an inverse elliptic problem with Neumann type overdetermination and construct a fourth order of accuracy difference scheme for its solution. Stability, almost coercive stability and coercive stability estimates for the solution of difference problem are proved. Later, we construct a fourth order difference scheme for an inverse problem for multidimensional elliptic equation with Neumann type overdetermination and Dirichlet boundary condition. Finally, we illustrate numerical example with descriptions of numeric realization in a two-dimensional case.
AtıfScopus19WoS12OpenAlex17İncele - BildiriAçık Erişim2017THE EFFICIENCY of RANDOM FOREST METHOD for SHORELINE EXTRACTION from LANDSAT-8 and GOKTURK-2 IMAGERIES
Bayram, B.; Erdem, F.; Akpinar, B.; Ince, A.K.; Bozkurt, S.; Catal Reis, H.; Seker, D.Z.; Karas, I.R.; Rahman, A.A.; Isikdag, U.
Coastal monitoring plays a vital role in environmental planning and hazard management related issues. Since shorelines are fundamental data for environment management, disaster management, coastal erosion studies, modelling of sediment transport and coastal morphodynamics, various techniques have been developed to extract shorelines. Random Forest is one of these techniques which is used in this study for shoreline extraction.. This algorithm is a machine learning method based on decision trees. Decision trees analyse classes of training data creates rules for classification. In this study, Terkos region has been chosen for the proposed method within the scope of "TUBITAK Project (Project No: 115Y718) titled "Integration of Unmanned Aerial Vehicles for Sustainable Coastal Zone Monitoring Model – Three-Dimensional Automatic Coastline Extraction and Analysis: Istanbul-Terkos Example". Random Forest algorithm has been implemented to extract the shoreline of the Black Sea where near the lake from LANDSAT-8 and GOKTURK-2 satellite imageries taken in 2015. The MATLAB environment was used for classification. To obtain land and water-body classes, the Random Forest method has been applied to NIR bands of LANDSAT-8 (5th band) and GOKTURK-2 (4th band) imageries. Each image has been digitized manually and shorelines obtained for accuracy assessment. According to accuracy assessment results, Random Forest method is efficient for both medium and high resolution images for shoreline extraction studies.
AtıfScopus23WoS18İncele - MakaleAçık Erişim2017Scopus SJRQ1Antiproliferative and apoptotic effect of Morus nigra extract on human prostate cancer cells
Turan, Ibrahim; Demir, Selim; Kilinc, Kagan; Burnaz, Nesibe Arslan; Yaman, Serap Ozer; Akbulut, Kubra; Mentese, Ahmet; Aliyazicioglu, Yuksel; Deger, Orhan
Background: Morus nigra L. belongs to the family Moraceae and is frequently used in traditional medicine. Numerous studies have investigated the antiproliferative effects of various extracts of different Morus species, but studies involving the in vitro cytotoxic effect of M. nigra extract are very limited. The purpose of this study was to evaluate the phenolic composition and antioxidant activity of dimethyl sulfoxide extract of M. nigra (DEM) and to investigate, for the first time, the probable cytotoxic effect in human prostate adenocarcinoma (PC-3) cells together with the mechanism involved. Methods: Total polyphenolic contents (TPC), ferric reducing antioxidant power (FRAP) and phenolic compounds of DEM were evaluated using spectrophotometric procedures and HPLC. The cytotoxic effect of DEM on PC-3 cells was revealed using the MTT assay. Mechanisms involved in the cytotoxic effect of DEM on PC-3 cells were then investigated in terms of apoptosis, mitochondrial membrane potential and cell cycle using flow cytometry, while caspase activity was investigated using luminometric analysis. Results: TPC and FRAP values were 20.7 ± 0.3 mg gallic acid equivalents and 48.8 ± 1.6 mg trolox equivalents per g sample, respectively. Ascorbic acid and chlorogenic acid were the major phenolic compounds detected at HPLC analysis. DEM arrested the cell cycle of PC-3 cells at the G1 phase, induced apoptosis via increased caspase activity and reduced mitochondrial membrane potential. Conclusions: Our results indicate that M. nigra may be a novel candidate for the development of new natural product based therapeutic agents against prostate cancer.
AtıfScopus71WoS66OpenAlex78İncele - MakaleAçık Erişim2017Scopus SJRQ2Excited Neutrino Search Potential of the FCC-Based Electron-Hadron Colliders
Caliskan, A.
The production potential of the excited neutrinos at the FCC-based electron-hadron colliders, namely, the ERL60⊗FCC with √s = 3.46 TeV, the ILC⊗FCC with √s = 10 TeV, and the PWFA-LC⊗FCC with √s = 31.6 TeV, has been analyzed. The branching ratios of the excited neutrinos have been calculated for the different decay channels and shown that the dominant channel is ∗→eW+. We have calculated the production cross sections with the process of ep→∗q→eW+q and the decay widths of the excited neutrinos with the process of ∗→eW+. The signals and corresponding backgrounds are studied in detail to obtain accessible mass limits. It is shown that the discovery limits obtained on the mass of the excited neutrino are 2452 GeV for Lint=100 fb-1, 5635 GeV for Lint=10 fb-1 (6460 GeV for Lint=100 fb-1), and 10200 GeV for Lint=1 fb-1 (13960 GeV for Lint=10 fb-1), for the center-of-mass energies of 3.46, 10, and 31.6 TeV, respectively.
AtıfScopus10WoS10OpenAlex13İncele - MakaleAçık Erişim2017Scopus SJRQ2Phenolic characterisation and antioxidant activity of Primula vulgaris and its antigenotoxic effect on fibroblast cells
Ozkan, Mehtap Tugce; Aliyazicioglu, Rezzan; Demir, Selim; Misir, Sema; Turan, Ibrahim; Yildirmis, Sermet; Aliyazicioglu, Yuksel
Background: Primula vulgaris has been used in traditional treatment, and its biological functions are attributed to its polyphenolics content. Objectives: The aim of this study was to determine the phenolics composition and the antioxidant activity of water extract of P. vulgaris (WEP) and to determine its probable preventive effects against H2O2-induced DNA damage in human fibroblast cells. Methods: The total polyphenolic content (TPC), ferric reducing antioxidant power (FRAP), and radical scavenging activity of WEP were determined using spectrophotometric methods. Phenolic compounds and antigenotoxic effects of WEP were evaluated using HPLC and comet assay, respectively. Results: The TPC and FRAP values of WEP were 15.023 ± 0.84 mg gallic acid and 82.63 ± 0.31 μM trolox per g sample, respectively. ρ-coumaric acid and rutin were detected as major phenolics. Moreover, WEP reducedH2O2-induced DNA damage in a concentration dependent manner in fibroblast cells compared to the positive controls (only 20 μMH2O2 treatment). Conclusions: Primula vulgaris can be used in food, cosmetics, and drug industries because of its antioxidant and antigenotoxic activities.
AtıfScopus26WoS30OpenAlex25İncele - MakaleAçık Erişim2017Scopus SJRQ2Comparison of stochastic and random models for bacterial resistance
Merdan, Mehmet; Bekiryazici, Zafer; Kesemen, Tulay; Khaniyev, Tahir
In this study, a mathematical model of bacterial resistance considering the immune system response and antibiotic therapy is examined under random conditions. A random model consisting of random differential equations is obtained by using the existing deterministic model. Similarly, stochastic effect terms are added to the deterministic model to form a stochastic model consisting of stochastic differential equations. The results from the random and stochastic models are also compared with the results of the deterministic model to investigate the behavior of the model components under random conditions.
AtıfScopus25WoS25OpenAlex25İncele - MakaleAçık Erişim2017Scopus SJRQ3Production of structured lipid with a low omega-6/omega-3 fatty acids ratio by enzymatic interesterification
Ilyasoglu, H.
A structured lipid (SL) constituting omega fatty acids was synthesized by using linseed and grape seed oils as substrates via a lipase-catalyzed reaction. Lipozyme® TL IM was used as a biocatalyst. Good quadratic models predicting the incorporation of omega fatty acids were achieved via the Response surface methodology (RSM). The optimal conditions for targeted omega-6/omega-3 fatty acid ratio (2:1) were obtained at a substrate molar ratio 1.4, time 8.4 h, and enzyme amount 6.4%. The SL contained linoleic acid (43 g 100g-1), which was mainly located in the sn-2 position (40 g 100g-1). α-Linoleic acid, and α-linolenic acid at the sn-2 position were 22 g 100g-1, and 11 g 100g-1, respectively. The oxidative stability of the SL, and SL with antioxidants was also investigated. The produced SL may be proposed as a source of a balanced intake of omega fatty acids and an ingredient in functional food formulations.
AtıfScopus5WoS4OpenAlex6İncele - MakaleAçık Erişim2017Scopus SJRQ4Association of IGF and IGFBP2 gene polymorphisms with growth and egg traits in Atak-S laying hens
Das, Huseyin; Tarim, B.; Demir, S.; Küçükkent, N.; Cengiz, S.; Tülek, E.; Aksakal, V.
Atak-S laying hens are a high-performance hybrid obtained by crossing of the Rhode Island Red (RIR) X the Barred Plymouth Rock (BR) and are being produced in the Ankara Poultry Research Institute since 1997. Phenotypic and genetic improving studies are continuous for this hybrid. In this study three different SNPs, two from IGF1 and one from IGFBP2 genes, were examined in 150 Atak-S chickens. Genetic association of SNPs were compared to body weight and egg number till 32 weeks of age, body weight at sexual maturity, age at sexual maturity and also egg quality traits such as egg shell breaking strength, shell thickness, Haugh unit, albumen index, yolk index and shape index were statistically analyzed. Only IGF1(a) locus was in agreement with Hardy-Weinberg equilibrium, while, the rest of the loci were not. As a result of the comparisons performed to the three SNPs, it was determined that there was a significant association (P < 0.05) between the T364C haplotypes of the IGF1(b) locus and body weight at 32 weeks of age, but there was not any association to the other traits.
AtıfScopus3WoS2OpenAlex4İncele - MakaleAçık Erişim2017Scopus SJRQ3Numerical solution to Bitsadze-Samarskii type elliptic overdetermined multipoint NBVP
Ashyralyyev, Charyyar
This paper is devoted to a Bitsadze-Samarskii type overdetermined multipoint nonlocal boundary value problem (NBVP). This inverse problem is reduced to an auxiliary multipoint NBVP. Stability estimates for the solution of the auxiliary NBVP are established. The finite difference method is applied to get the first and second order of accuracy of approximate solutions of the abstract overdetermined problem. Stability estimates for the solution of difference problems are proved. Then the established abstract results are applied to get stability estimates for the solution of the Bitsadze-Samarskii type overdetermined elliptic multidimensional differential and difference problems with multipoint nonlocal boundary conditions (NBVC). Finally, numerical results with explanation on the realization for two dimensional and three dimensional elliptic overdetermined multipoint NBVPs in test examples are presented.
AtıfScopus30WoS23OpenAlex27İncele - MakaleAçık Erişim2017Scopus SJRQ3Morus rubra extract induces G1 cell cycle arrest and apoptosis in human lung and prostate cancer cells
Turan, Ibrahim; Demir, Selim; Kilinc, Kagan; Aliyazicioglu, Yuksel; Alver, Ahmet; Misir, Sema; Yaman, Serap Ozer; Akbulut, Kubra; Mentese, Ahmet; Deger, Orhan
Objective: Cancer is one of the most deadly types of disease and evasion from apoptosis and unstoppable cell proliferation are accepted as its distinctive features. Many studies have evaluated the cytotoxic effect of different Morus species but, there is no study about cytotoxic effect of Morus rubra. In this study we aimed to evaluate phenolic composition, antioxidant properties and cytotoxic effect of acidified dimethyl sulfoxide extract of M. rubra (AMRE). Method: Antioxidant properties, phenolic composition and cytotoxic effect of AMRE were determined using spectrophotometric methods, HPLC, and MTT assay, respectively. Then, mechanisms of cytotoxic effect of AMRE on human prostate (PC-3) and lung (A549) cancer cells were examined in regard to cell cycle, apoptosis and mitochondrial membrane potential using flow cytometric methods. Results: Total phenolic content and reducing power values were 11.9 mg gallic acid equivalents and 42.9 mg trolox equivalents per g sample, respectively. Ascorbic and gallic acid were detected in AMRE as major antioxidant compounds. We determined that AMRE increased cell cycle arrest at G1 phase and exhibited apoptotic features via decreasing mitochondrial membrane potential in both prostate and lung cancer cells. Conclusion: These findings demonstrate that M. rubra extract can affect the behavior of human prostate and lung cancer cells in vitro conditions, and this effect now needs to be investigated in vivo.
AtıfScopus5WoS11OpenAlex11İncele - MakaleAçık Erişim2017Scopus SJRQ3Cytotoxic effect of Laurocerasus officinalis extract on human cancer cell lines; [Laurocerasus officinalis ekstraktının İnsan kanser hücre serileri üzerindeki sitotoksik etkisi]
Demİr, Selim; Turan, İbrahim; Demİr, Feyza; Ayazoğlu Demİr, Elif; Alıyazicioğlu, Yuksel
Laurocerasus officinalis Roem. (Prunus laurocerasus L.), also locally known as “karayemis or taflan”, is a popular black summer fruit belonging to the genus Prunus and the family Rosaceae. L. officinalis exhibits numerous biological activities, such as anti-inflammatory, antinociceptive, antioxidant, neuroprotective, and antidiabetic effects. The aim of this study was to determine the total phenolic content and cytotoxic effect of dimethyl sulfoxide extract of L. officinalis (DEL). The total phenolic content and cytotoxic effect of DEL were investigated using the Folin-Ciocalteu method and thiazolyl blue tetrazolium bromide (MTT) assay, respectively. Total phenolic content value was 33.7±0.13 mg gallic acid equivalent per g sample. DEL exhibited selective cytotoxic effects against four human cancer (lung, colon, liver, and cervix) cell lines. The most selective cytotoxic effect of the extract was observed in colon cancer cells (IC50=265.2±8.1 μg/mL) compared to normal fibroblast cells. These data demonstrate that L. officinalis extract exhibits selective cytotoxicity towards some cancer cells. Further studies are now needed to clarify the molecules involved and their mechanisms.
AtıfScopus17WoS21OpenAlex34TR Dizin14İncele - MakaleAçık Erişim2017Scopus SJRQ3Effect of the Simultaneous Variation in Blade Root Chord Length and Blade Taper on Helicopter Flight Control Effort
Oktay, Tugrul; Sal, Firat
In this study, the effect of simultaneous variation in blade root chord length and blade taper on the control effort of helicopter flight control system (i.e., FCS) of a helicopter is investigated. Therefore, helicopter models (i.e., complex, control-oriented, and physics-based models) including the main physics and essential dynamics are used. The effect of simultaneous variation in the blade root chord length and blade taper (i.e., in both chordwise and lengthwise directions dependently) on the control effort of an FCS of a helicopter and also on the closed-loop responses is studied. Comparisons in terms of the control effort and peak values with and without variations in the blade root chord and blade taper changes are carried out. For helicopter FCS variance-constrained controllers, specific output variance-constrained controllers are beneficial.
AtıfScopus13WoS11OpenAlex16İncele