Sürdürülebilir Kalkınma Amaçları

Yazarlar

  • MakaleAçık Erişim2026Scopus SJRQ1
    Chemical profiling, biological evaluation, and QSAR-informed metabolite prioritization of Hypericum ekerii: a first report on antioxidant, enzyme inhibitory, and cytotoxic activities

    Zengin, Gokhan; Yagi, Sakina; Cetiz, Mehmet Veysi; Uba, Abdullahi Ibrahim; Nikolic, Filip; Gasic, Uros; Balos, Mehmet Maruf; Erharman, Ahmet; Dogan, Nurettin; Koyuncu, Ismail

    Hypericum ekerii Y & uuml;ce and Ayta & ccedil;, first described in 2017, remains poorly characterized in terms of its phytochemical composition and biological properties. This study investigated aerial-part extracts of H. ekerii prepared with ethyl acetate, acetone, 70% acetone-water, and water. The hydroacetone extract showed the highest total phenolic and flavonoid contents. LC/MS analysis enabled the annotation of 99 constituents, including phenolic acids, flavonoids, xanthones, anthraquinones, and acylphloroglucinols. The hydroacetone extract exhibited the strongest radical-scavenging and reducing activities, whereas acetone and ethyl acetate extracts showed the highest metal-chelating capacity. In enzyme assays, hydroacetone was the most active extract against acetylcholinesterase, tyrosinase, and hCA II, while ethyl acetate showed greater inhibition of butyrylcholinesterase and hCA I. The aqueous extract was the most active against alpha-glucosidase, and hydroacetone and ethyl acetate showed comparable alpha-amylase inhibition. Cytotoxicity remained limited overall; the lowest IC50 value was observed for the ethyl acetate extract against HCT-116 cells (95.09 & micro;g mL-1), with weak selectivity (SI = 1.2). A QSAR-informed prioritization framework identified myricetin as the leading cross-layer candidate, p-coumaric acid as a target-specific priority metabolite, and ellagic acid, quercetin, and caffeic acid as antioxidant-priority candidates. Molecular docking supported favorable binding profiles for selected metabolites, while molecular dynamics simulations were used to assess the stability of representative complexes. Overall, H. ekerii appears to be a chemically diverse species with notable antioxidant and enzyme-inhibitory potential, providing a focused basis for future compound-level validation.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
  • MakaleYalnız künye2026Scopus SJRQ1
    Geochemical signature, detrital zircon U-Pb, and mica Ar-Ar age systematics from the Karadere Basement Unit of the İstanbul-Zonguldak Terrane (NW, Türkiye): evidence for an Avalonian-Cadomian active continental margin

    Çimen, Okay; Gücer, Mehmet Ali; Göncüoglu, Mehmet Cemal; Akal, Cuneyt; Arslan, Mehmet; Simonetti, Antonio; Karaoglan, Fatih

    The & Idot;stanbul-Zonguldak Terrane is located in northwest Anatolia and includes several outcrops with pre-Cambrian basement units. The Karadere Basement Unit represents the easternmost basement of this terrane and is composed of paragneiss, quartzite, and orthogneiss. The paragneiss and quartzite are cut by orthogneisses and disconformably overlain by Lower Ordovician to Middle Devonian cover units. Its pre-Cambrian to Palaeozoic tectonic evolution remains poorly understood, and therefore, this study reports whole-rock trace element signatures, detrital zircon U-Pb, and muscovite Ar-Ar age data for samples of paragneiss, quartzite, amphibolite, and orthogneiss. The whole-rock geochemical data indicate that the protoliths of the paragneiss and quartzite samples investigated here could have been derived from arc-related felsic magmatic units located in an active continental margin. The protoliths of amphibolites and orthogneiss samples are gabbro and granite, respectively, and their geochemical signatures are akin to those from continental arc igneous suites. The detrital zircon U-Pb data are characterized by predominantly Mesoproterozoic (84%) and lesser amount of Palaeoproterozoic and Neoproterozoic ages and suggest an early Tonian (youngest peak age of 915 +/- 18 Ma) maximum depositional age. Moreover, zircon U-Pb dating analyses from an orthogneiss sample yielded an age of 603 +/- 2 Ma, indicating the occurrence of mid-Ediacaran arc magmatism. This represents one of the oldest Ediacaran ages obtained from the metamagmatic basement rocks of the & Idot;stanbul-Zonguldak Terrane. Ar-Ar dating of muscovite from ortho- and paragneiss samples yielded ages of 533 +/- 25 Ma and 530 +/- 9 Ma, respectively, which are interpreted as early Cambrian cooling ages. Overall, the combined results reported here reveal that the Karadere Basement Unit is markedly different from NE African basement units but displays similarities to the basement rocks of both Avalonian and Amazonian terranes. It may have been formed and metamorphosed in an Avalonian-Cadomian active continental margin during the mid- to late Neoproterozoic and early Cambrian.

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  • MakaleAçık Erişim2026Scopus SJRQ2
    Long-term decline of Chernobyl-derived 137Cs in mosses and lichens from the Eastern Black Sea region of Türkiye

    Çevik, Ugur; Çelik, Necati; Uzun, Kubra K.; Çelik, Ahmet; Koz, Bahadir; Özen, Songul A.; Yesilkanat, Cafer M.; Hacisalihoglu, Aylin; Özkalayci, Fatih; Kaya, Selim

    This study presents the third consecutive assessment of 13 Cs activity concentrations in the same 50 moss (7 species) and lichen (2 species) sampling points in Ordu province, T & uuml;rkiye, one of the most heavily contaminated areas following the Chernobyl accident. Samples were collected from exactly the same locations used in the 1997 and 2007 studies and analyzed by high-resolution gamma spectrometry. In 2025, detectable 13 Cs was found in 14 of 30 moss sites (47%) and 3 of 20 lichen sites (15%). For samples below the minimum detectable activity (MDA), a value of MDA/2 (0.93 Bq kg-1) was substituted for lichens, while moss samples below the MDA were excluded from regression. The ecological half-life (Teco) for the 2007-2025 period was 4.38 +/- 1.05 years for mosses and 4.18 +/- 0.61 years for lichens. For mosses, this is nearly identical to the 1997-2007 mean (4.4 years), while for lichens it decreased from 5.6 to 4.18 years, suggesting a slight acceleration in environmental removal. All Teco values remain far shorter than the physical half-life of 13 Cs (30 years), confirming that environmental removal processes dominate over radioactive decay. Residual 13 Cs is concentrated in higher-altitude areas, reflecting the original deposition pattern and slower removal in cooler, more humid microenvironments. Nearly 39 years after the accident, the radiological risk posed by residual trace levels is negligible. This 28-year dataset provides one of the longest continuous records of 13 Cs in epiphytic bioindicators and serves as a valuable baseline for future contamination events.

    • SDG 15 · Karasal Yaşam
  • MakaleAçık Erişim2026Scopus SJRQ3
    Mono- and Bis-Ureido Sulfapyridines as Nanomolar Dual Cholinesterase Inhibitors: Enzyme Kinetics, Molecular Docking, and ADME/Tox Insights

    Yapar, Gonul; Akocak, Suleyman; Lolak, Nebih; Topal, Meryem; Türkes, Cuneyt; Topal, Fevzi; Durgun, Mustafa; Koçyigit, Umit Muhammet; Isik, Mesut; Beydemir, Sukru

    A series of mono- and bis-ureido sulfapyridine derivatives (SP-1-SP-10) were synthesized and evaluated as dual cholinesterase inhibitors targeting acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). All compounds exhibited nanomolar inhibition. The most potent AChE inhibitors were SP-8 (K-i = 5.25 +/- 0.73 nM), SP-9 (5.09 +/- 0.44 nM), and SP-10 (5.74 +/- 0.55 nM), significantly outperforming tacrine (K-i = 105.03 +/- 8.85 nM) under identical conditions. For BChE, SP-9 showed the strongest inhibition (K-i = 26.38 +/- 2.07 nM) compared with tacrine (172.03 +/- 32.42 nM). Kinetic analyses revealed competitive inhibition toward AChE for all derivatives, whereas BChE inhibition displayed both competitive and noncompetitive patterns depending on structural features. Glide XP docking using AChE (PDB: 7XN1) and BChE (PDB: 4BDS), complemented by MM-GBSA binding free energy calculations, supported favorable ligand accommodation within the catalytic pockets and highlighted the importance of aromatic and hydrophobic interactions. In silico ADME/Tox analysis revealed a potency-drug-likeness trade-off: mono-ureido derivatives complied with Lipinski's rule of five and showed high predicted oral absorption, whereas bis-ureido derivatives, despite superior enzymatic potency, exhibited multiple drug-likeness violations. These findings identify the ureido-sulfapyridine scaffold as a potent enzymatic dual cholinesterase inhibitory framework, warranting further structural optimization to improve pharmacokinetic properties.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
  • MakaleAçık Erişim2026Scopus SJRQ1
    YOLOv8 computer vision for automated offside detection in professional football validated through supervised learning

    Abdel-Fattah, Abdul-Rahman; Belhaouari, Samir Brahim; Ceylan, Halil Ibrahim; Bayrakdaroglu, Serdar; Muntean, Raul Ioan; Dhahbi, Wissem; Dergaa, Ismail; Omri, Abdelfatteh El

    Offside calls are integral to maintaining fairness and competitive integrity in football, yet current officiating processes are constrained by limitations in accuracy despite technological advancements. This investigation developed and validated an automated offside detection system using YOLOv8 object detection architecture to address documented limitations of Video Assistant Referee (VAR) systems in offside decision accuracy. Supervised learning validation employed 400 annotated instances from professional match footage. The YOLOv8 medium variant was configured for four-class detection, with a focus on extreme player positions, reducing computational complexity by approximately 70% relative to comprehensive player tracking while accepting accuracy trade-offs in marginal scenarios. The system was optimized for computational efficiency through highly accurate tracking of player positions. Data were partitioned into 40% (n = 160) for training and 60% (n = 240) for testing, with 5-fold cross-validation. The automated system achieved robust performance metrics across 240 test instances: overall accuracy of 83.0%, precision of 85.0%, recall of 87.0%, and F1-score of 86.0%. Confusion matrix analysis revealed true positives (n = 130), true negatives (n = 70), false positives (n = 22), and false negatives (n = 18). Individual case analysis demonstrated 80% agreement with ground truth classifications. System performance significantly exceeded the random classification baseline (p < 0.001). The strategic extreme player tracking approach achieved substantial computational efficiency while maintaining decision accuracy across diverse match scenarios. A YOLOv8-based offside detection system demonstrates proof-of-concept feasibility for decision-support applications in football officiating. Performance (83% accuracy, 95% CI: 79-87%) on 240 test instances remains below professional benchmarks (> 93%), with single-camera constraints and limited dataset size restricting generalizability to proof-of-concept validation rather than operational deployment.

  • MakaleAçık Erişim2026Scopus SJRQ1
    Short-Term Inspiratory Muscle Training Enhances Functional and Metabolic Health in Older Adults

    Konca, Erkan; Yilmaz, Coskun; Bayrakdaroglu, Serdar; Ceylan, Halil Ibrahim; Arslan, Ayla; Ocak, Hakan; Karakulak, Izzet; Sari, Rifat; Uzun, Recep Nur; Soylu, Hakan Huseyin

    Background: Age-related declines in respiratory muscle strength and ventilatory efficiency can impair functional capacity and metabolic health in older adults. Inspiratory muscle training (IMT) has been proposed as a practical intervention to counteract these changes, yet its systemic effects remain unclear. This study aimed to examine the effects of short-term IMT on functional capacity, diaphragm thickness, and liver tissue characteristics in healthy elderly men. Methods: Thirty community-dwelling men aged 60-80 years were randomly assigned to an IMT or control group. The IMT group performed four weeks of breathing exercises using a POWERbreathe (R) device at 40% of maximal inspiratory pressure, with a weekly 10% increase in pressure. Pre- and post-intervention assessments included the six-minute walk test (6MWT), diaphragm thickness and liver density via computed tomography, and quality of life (QoL; SF-12). Results: Four weeks of inspiratory muscle training significantly improved diaphragm thickness (11.7%), fatty liver density (FLD) (+16.7%), and six-minute walk performance (+5.3%), with large time x group effects favoring the IMT group. While the physical quality of life showed modest, comparable improvements, mental health outcomes demonstrated a moderate, time-dependent improvement without a significant group-by-time interaction. Conclusions: Short-term IMT improved diaphragmatic function and functional capacity in older men and was associated with favorable changes in a liver-related biomarker; however, given that only a single liver-related metric was assessed, these findings should not be interpreted as evidence of overall improvements in liver health.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus1WoS1OpenAlex3
    ScopusWeb of SciencePubMedİncele
  • MakaleYayıncıda açık erişim2026Scopus SJRQ1
    The mediating role of mental fatigue awareness in the relationship between perceived stress and psychological well-being among combat athletes

    Yilmaz, Taner; Öz, Faik; Gül, Oguzhan; Dal, Suzan; Kara, Tayfun; Akkoç, Orkun; Küçük, Hamza; Fort, Patricia Roxana; Çitozi, Robert; Kadi, Mustafa Nurullah

    Background Combat athletes face unique psychological demands, and stress may influence both their cognitive experiences and psychological well-being. This study aimed to examine the mediating role of mental fatigue awareness in the relationship between perceived stress and psychological well-being among combat athletes, thereby contributing to a clearer understanding of a potential cognitive mechanism linking stress to well-being in this population.Methods A total of 303 combat athletes voluntarily participated. Participants completed the Perceived Stress Scale, Mental Fatigue Awareness Scale, and Psychological Well-being Scale. Statistical analyses assessed the direct effects of perceived stress on psychological well-being, the effect of stress on mental fatigue awareness, and the potential mediating role of mental fatigue awareness.Results Perceived stress significantly increased mental fatigue awareness (b = 0.732, SE = 0.064, beta = 0.549, p = 0.001) and directly decreased psychological well-being (b = - 0.488, SE = 0.166, beta = - 0.191, p = 0.004). Mental fatigue awareness negatively affected psychological well-being (b = - 0.374, SE = 0.124, beta = - 0.195, p = 0.003) and partially mediated the relationship between stress and well-being (indirect effect: b = - 0.274, SE = 0.115, beta = - 0.107, p = 0.003; 95% CI = - 0.504 to - 0.049).Conclusion Perceived stress was associated with psychological well-being both directly and indirectly through increased mental fatigue awareness. These findings suggest that mental fatigue awareness may represent a relevant cognitive pathway linking stress perceptions to well-being. Accordingly, stress management and strategies aimed at regulating mental fatigue may be considered as potentially beneficial components in efforts to support psychological well-being among combat athletes.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfWoS1OpenAlex2
    ScopusWeb of SciencePubMedİncele
  • MakaleYalnız künye2026Scopus SJRQ1
    Chemical characterization and bioactivity assessment of Erodium cedrorum subsp. salmoneum extracts supported by in silico analysis

    Yagi, Sakina; Zengin, Gokhan; Zoltan, Cziaky; Jeko, Josef; Ivashchanka, Yahor; Turecka, Katarzyna; Halasa, Rafal; Gucwa, Magdalena; Kochan-Jamrozy, Kinga; Stefanowicz-Hajduk, Justyna

    The growing interest in natural products, particularly as food additives and pharmaceutical raw materials, is making research into discovering new sources especially important. Erodium cedrorum subsp. salmoneum (family Geraniaceae) is used traditionally to cure many ailments like diabetes and gastro-intestinal diseases. Within this background, the current study was designed to investigate, for the first time, the chemical composition, antioxidant and enzyme inhibitory poroperties of different extracts from the aerial parts and roots of E. cedrorum. Results revealed that the aqueous extract of the aerial parts accumulated the highest total phenolic (85.35 mg GAE/g) and flavonoids (28.65 mg RE/g) contents. A total of 61 and 45 compounds, belonging mainly to phenolic acids and flavonoids, were tentatively identified in the aerial parts and roots extracts respectively. The aqueous extract from the aerial parts exerted the highest antiradical, ions reducing and chelation properties. The EtOH and 70% EtOH extracts of the two organs recorded the best anti-acetylcholinesterase activity (2.18 -2.41 mg GALAE/g; p >= 0.05) while those of the roots recorded respectively the best anti-butyrylcholinesterase and antityrosinase activities. The most potent antibacterial activity was exhibited by the 70% EtOH extracts from aerial parts and the pure EtOH extracts from roots. In contrast, ethyl acetate extracts from both plant parts showed only marginal activity. Among the tested strains, the highest susceptibility was observed against C. sporogenes ATCC 19404, C. bifermentans ATCC 638, S. aureus ATCC 6538, S. aureus ATCC 43300 (MRSA), C. diphtheriae PCM 506, and H. pylori ATCC 43504. The extracts were also examined for their anti-cancer potential on the HeLa, AGS and SKOV-3 cell lines, as well as a non-cancerous cell line. The ethyl acetate extract of the roots exhibited the most potent anti-cancer activity, with the lowest IC50 values. In addition, selected top-ranked complexes against AChE, alpha-amylase, representative bacterial and oncogenic targets were further evaluated by molecular docking and 100 ns molecular dynamics (MD) simulations, indicating overall conformational stability and persistent binding. In conclusion, these results position E. cedrorum as a valuable natural source of antioxidant and enzyme-inhibitory agents, meriting further exploration for drug development purposes.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus1WoS2OpenAlex2
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2026Scopus SJRQ1
    Effects of wrestling training on psychological well-being, anxiety, and resilience in adolescent boys

    Özkan, Ridvan; Yilmaz, Coskun; Uzun, Recep Nur; Bayrakdaroglu, Serdar; Akar, Ozge Orhan; Öz, Faik; Çiçekli, Atif; Çiçekli, Aylin; Dal, Suzan; Ursu, Vasile Emil

    Background Wrestling is a physically and mentally demanding combat sport that requires discipline, focus, and emotional control. Although its physiological effects are well documented, its psychological benefits in adolescents remain underexplored. This study aimed to examine whether a short-term, non-competitive wrestling program could enhance psychological well-being, reduce sport anxiety, and strengthen resilience in adolescent boys. Methods Thirty sedentary male adolescents (aged 12-15 years) were randomly assigned to a wrestling training group (n = 15) or a control group (n = 15). The intervention consisted of six weeks of supervised wrestling sessions performed three times per week. Psychological well-being (WHO-5), sport anxiety (SAS-2), and resilience (BPRS) were assessed before and after the intervention using the validated Turkish versions of the scales. Two-way repeated-measures ANOVA was used to analyze group & times; time interactions. Results Participants in the wrestling group demonstrated significant improvements in well-being (p < 0.001) and resilience (p < 0.001), alongside marked reductions in total sport anxiety and its subdimensions (p < 0.001), compared with the control group. All effects were large (eta p & sup2; = 0.52-0.94). Conclusion A structured six-week wrestling program produced meaningful psychological benefits in adolescent boys. Regular participation in non-competitive wrestling may serve as an effective approach to promote well-being, emotional stability, and adaptive coping skills during early adolescence, supporting the preventive and developmental role of combat sports in youth mental health.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus3WoS5OpenAlex10
    ScopusWeb of SciencePubMedİncele
  • MakaleYalnız künye2026Scopus SJRQ1
    Building Resilience in Global Tourism: A Theoretical and Empirical Analysis of Indicators for Sustainable Development

    Erol, Ismail; Dogru, Tarik; Oztel, Ahmet; Bilgihan, Anil; Peker, Iskender; Neuhofer, Irem Onder

    The primary perspective of this study is the global tourism industry (GTI) as an interconnected supply chain network, encompassing both tourism firms (e.g., hotels, airlines, and operators) and destinations (e.g., local communities and ecosystems). This industry-level focus allows for analyzing resilience indicators that bridge firm-specific capabilities with destination-wide vulnerabilities, rather than isolating one over the other. Using a mixed-method approach, this research conceptualizes resilience through various management theories. First, it identifies critical resilience indicators across institutional, societal, economic, and ecological dimensions. Second, these indicators are analyzed with a novel Spherical Fuzzy Interpretive Structural Modeling and Cross-Impact Matrix Multiplication Applied to Classification framework, utilizing expert opinions to uncover complex interdependencies among indicators. The findings of this study highlight that effective government policies, robust incentive mechanisms, advanced digital infrastructure, dynamic capabilities, and ecologically sustainable tourism practices are key drivers of resilience. However, socioeconomic impacts, tourist satisfaction, and price competitiveness emerge as highly dependent outcomes influenced by these drivers. This study also introduces the Adaptive Global-Local Interaction Theory, a new framework that integrates global influences with local realities to enhance tourism resilience. By offering a comprehensive framework and practical guidelines, this research equips policymakers and stakeholders with actionable strategies to bolster the industry's capacity to anticipate, adapt to, and recover from crises, promoting sustainable development amidst volatile global conditions.

    • SDG 8 · İnsana Yakışır İş ve Ekonomik Büyüme
    • SDG 9 · Sanayi, Yenilikçilik ve Altyapı
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  • MakaleYalnız künye2026Scopus SJRQ2
    Comparison of automated subcortical segmentation methods: VolBrain vs. 3D Slicer in brain volumetry

    Acer, Niyazi; Palanci, Ozgur; Ipekten, Funda; Erdogan, Furkan Mert; Yarar, Burhan; Ozyasar, Ali Faruk

    Objective:Accurate volume measurements of subcortical brain structures are essential in neuroimaging studies. This study aimed to compare two automated segmentation algorithms, 3D Slicer and VolBrain, for subcortical brain volumetry. Method:Subcortical volume measurements obtained using 3D Slicer and VolBrain were compared using the Neurofeedback Skull-stripped (NFBS) dataset. Statistical analyses included the coefficient of determination (R2) and Bland-Altman (B-A) plots. Volumetric measurements from both tools were evaluated across multiple subcortical brain regions. Results:Strong agreement was observed for the caudate nucleus, thalamus, and hippocampus, while notable discrepancies were identified in the amygdala, globus pallidus, and nucleus accumbens. Both constant and proportional systematic errors were detected in certain regions, with greater variability observed in 3D Slicer measurements. Intraclass Correlation Coefficient (ICC) analysis demonstrated weak agreement for the accumbens and amygdala, and moderate agreement for the hippocampus and thalamus, highlighting region-specific differences in performance Conclusion:Both VolBrain and 3D Slicer are effective tools for subcortical brain volumetry. VolBrain provides a fully automated workflow, whereas 3D Slicer allows greater flexibility through detailed corrections. Method selection should be guided by research objectives, regions of interest, and image quality. Further validation across diverse datasets is warranted to improve clinical applicability, particularly in regions showing lower agreement.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
  • MakaleAçık Erişim2026Scopus SJRQ1
    Modeling Long-Term Postseismic Deformation Following the 2020 Mw 7.0 Samos Earthquake Using Campaign and Continuous GNSS Observations

    Solak, Halil Ibrahim; Tiryakioglu, Ibrahim; Gezgin, Cemil; Aladogan, Kayhan; Yalvaç, Sefa; Aktug, Bahadir; Yigit, Cemal Ozer; Dönmez, Ergin; Demirelli, Ertugrul; Eyübagil, Eda Esma

    Highlights What are the main findings? What are the implications of the main findings?Highlights What are the main findings? What are the implications of the main findings?Abstract Postseismic deformation provides fundamental insights into earthquake-cycle processes, lithospheric rheology, and stress redistribution following large earthquakes. Although the 2020 Mw 7.0 Samos earthquake has been extensively investigated in terms of coseismic deformation and early postseismic behavior, the long-term evolution of deformation following the event remains poorly constrained. This study characterizes the long-term spatiotemporal evolution of postseismic deformation associated with the 2020 Mw 7.0 Samos earthquake using combined campaign and continuous GNSS observations. A total of 18 GNSS stations were analyzed over an approximately 4.5-year period following the earthquake. Pre-earthquake GNSS velocities were incorporated as prior constraints, while postseismic deformation was modeled using linear, logarithmic, exponential, and combined logarithmic-exponential functions. The preferred model for each station component was identified using the corrected Akaike Information Criterion (AICc), and model-selection robustness was evaluated through 1000 Monte Carlo observation-perturbation simulations. The results reveal a spatially heterogeneous postseismic deformation field with station-dependent temporal behavior. Among the nonlinear solutions passing the Monte Carlo and goodness-of-fit criteria, the seven single-process LOG and EXP solutions yielded characteristic relaxation times ranging from 182.6 to 730.5 days, with a median of 438.3 days. The two LOGEXP solutions additionally contained a logarithmic timescale of 109.6 days and exponential timescales of 292.2-438.3 days. These findings demonstrate that campaign GNSS observations, when integrated with continuous GNSS data and an objective statistical framework, can provide meaningful constraints on the long-term evolution of postseismic deformation despite sparse temporal sampling. More broadly, the results emphasize the strongly time-dependent nature of postseismic deformation and the critical role of observation timing in capturing its spatiotemporal evolution.

  • MakaleYalnız künye2026Scopus SJRQ1
    Petrogenetic constraints and phase equilibria modelling on amphibole-bearing high-grade metamafic rocks from the Maku ophiolite (NW Iran): implications for metamorphism along the central Neo-Tethyan suture

    Modjarrad, Monir; Uysal, Ibrahim; Yara, Irfan O. M. A.; Sen, Ahmet Dundar; Xin, Guangyao; Müller, Dirk

    We present an integrated petrological, mineral-chemical, whole-rock geochemical, microstructural, and phase-equilibrium study of the West Maku metamafics (WMM), an ophiolite-related mafic unit in NW Iran. The WMM comprises garnet amphibolites and amphibole-bearing high-grade metamafic rocks containing almandine-rich garnet, tschermakite-ferro-tschermakite, andesine, epidote/zoisite, annite, muscovite-phengite, spinel, ilmenite, chlorite, quartz, and K-feldspar. Immobile element systematics indicate a tholeiitic, MORB-like basaltic protolith; LILE and crust-sensitive element enrichment likely reflect inherited crustal/sediment-derived components and metamorphic redistribution during subduction-accretion and/or m & eacute;lange assembly. P-T modelling defines four relative stages: M1, upper greenschist-facies metamorphism at ca. 6.4 kbar and 360 degrees C; M2, prograde heating to 8.0-8.4 kbar and 700-720 degrees C; M3, peak upper-amphibolite- to granulite-facies conditions at 9.0-9.8 kbar and up to 810 degrees C, with localized anatexis; and M4, retrogression at ca. 3.8 kbar and 520 degrees C. The clockwise path records the burial and heating of MORB-derived crust in a subduction-accretionary setting, followed by collision-related thermal relaxation/crustal thickening and subsequent uplift. Regional comparisons indicate thermally heterogeneous evolution along the central Neo-Tethyan suture across Armenia, SE T & uuml;rkiye, NE Iraq and NW Iran.

  • MakaleAçık Erişim2026Scopus SJRQ1
    Designing an industrial-scale radio frequency decontamination process for peanut butter

    Coskun, Eda; Ozturk, Samet; Tasci, Caner; Kahraman, Kubra; Liu, Shuxiang; Li, Rui; Wang, Shaojin; Mert, Behic; Marra, Francesco; Erdogdu, Ferruh

    Centers for Disease Control and Prevention (CDC) has reported outbreaks of Salmonella, particularly associated with low-moisture foods including peanut butter. Even though roasting is included along the processing line, the presence of these safety issues indicates the requirement of process following the packaging of the samples. Because of the lower thermal diffusivity of the peanut butter, a conventional thermal process is expected to be challenging with expected temperature non-uniformities. Therefore, radio frequency (RF) heating was considered in this study for thermal processing of peanut butter samples. For this purpose, a computational model was developed to determine the temperature change of peanut butter samples. Experimental studies for model validation were completed in a 10 kW - 27.12 MHz RF system at 3300 and 4000 V electrode potentials. Following the model validation, a comparison to the conventional thermal processing was presented, and industrial scale thermal processing studies were applied where up to 30 packaged samples were placed within the RF cavity. Process efficiency was determined with the process time decrease, temperature uniformity and decontamination effects. Science4Impact: This study demonstrated RF processing for an efficient thermal decontamination with uniform temperature distribution attained within the samples in an industrial scale process.

    • SDG 2 · Açlığa Son
  • MakaleAçık Erişim2026Scopus SJRQ2
    In Vitro Antioxidant, Antibacterial, and Cholinesterase-Inhibitory Properties of an AqueousEuphorbia macrocladaRoot Extract Obtained by Ultrasound-Assisted Extraction

    Gül, Abdulkadir; Yilmaz, Firat; Topal, Fevzi; Özgen, Inanc; Aydogmus, Ercan; Arslanoglu, Hasan

    In the present study, the aqueous extract obtained from the roots of Euphorbia macroclada via ultrasound-assisted extraction (Ult-ER) was evaluated for its anticholinesterase (AChE and BChE), antioxidant, and antibacterial activities. While the extract exhibited weak inhibition against AChE (IC50: 507.69 +/- 17.95 mg/mL), it showed relatively greater inhibitory activity against BChE (IC50: 22.41 +/- 0.49 mg/mL). In antioxidant assays, Ult-ER exhibited measurable antioxidant responses, with DPPH and ABTS(+) radical-scavenging capacities of 18.33 +/- 0.49 and 119.59 +/- 1.86 mg TE/L, respectively. Its Fe-3(+) and Cu-2(+) reducing capacities were 128.51 +/- 12.57 and 670.33 +/- 11.59 mg TE/L, respectively. The total phenolic and flavonoid contents were 84.80 +/- 3.31 mg GAE/g and 60.67 +/- 2.29 mg QE/g, while the total antioxidant capacity was 9.78 +/- 0.44 mg TE/g and 15.62 +/- 1.85 mg BHAE/g. In the antibacterial evaluation, Ult-ER at the highest tested concentration of 8 mg/mL exhibited inhibitory activity against all tested strains, including Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853, whereas no detectable inhibition was observed at lower concentrations.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
  • MakaleAçık Erişim2026Scopus SJRQ2
    A combined Monte Carlo, analytical, and experimental study of true coincidence summing correction factors for 152Eu

    Çelik, Necati; Ali, Ahmed H.; Apaydin, Gokhan; Çevik, Ugur; Açikel, Selami

    The radionuclide 152Eu presents a significant challenge in gamma-ray spectrometry due to its complex decay scheme and significant true coincidence summing (TCS) effects, especially in close-measurement geometries. This study presents a comprehensive investigation into TCS correction factors for the principal gamma-ray lines of 152Eu using tripartite methodology: a custom Monte Carlo (MC) simulation based on the EGS4 system, an established analytical method, and direct experimental measurements. The MC simulation explicitly models the complete decay process, including branching ratios, gamma emissions, internal conversion, and subsequent X-ray emissions for both decay branches (beta-minus to 152Gd and EC to 152Sm). Experimentally, correction factors were derived using a well-characterized point source measured at multiple distances with a coaxial HPGe detector. The analytical, method based on probabilistic analysis of the decay scheme, served as an examination. Results demonstrate that the analytical method underestimated the TCS correction factors, particularly for low-energy lines such as 121.78 keV, where it predicted a mere 0.78 % correction compared to 25.5 and 23.5 % from MC and experiment, respectively. This discrepancy is attributed to the analytical method's neglect of gamma-X ray coincidences and the internal conversion effects. In contrast, the MC simulation showed remarkable agreement with experimental results across all energies, validating its capability to accurately model the full complexity of TCS effects. The study concludes that while analytical methods offer rapid estimates, MC simulations, especially when experimentally validated, are essential for achieving metrological accuracy in the gamma-ray spectrometric analysis of complex radionuclides like 152Eu.

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    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2026Scopus SJRQ2
    Tomography of the source zone of the February 6, 2023, Kahramanmaras, Earthquake Doublets of Southern Anatolia

    Salah, Mohamed K.; Alkan, Hamdi; Öztürk, Serkan; Güney, Recep

    On February 6, 2023, two destructive earthquakes and many posterior aftershocks hit the Kahramanmaras,area in southern Anatolia. The Kahramanmaras, earthquake sequence (KMES) caused extensive damage and economic losses in T & uuml;rkiye and Syria. In this study, the 3-D crustal seismic velocities surrounding the hypocentral region of the KMES are determined using a large dataset of body wave arrival times obtained from local earthquakes. To better constrain the physical properties and seismogenic behavior of the KMES source region, the Vp/Vs ratio is calculated and correlated with Poisson's ratio using the obtained velocity models. To gain a better understanding of the stress conditions and regional earthquake activity in the study area, the depth variation of the b-value is also examined. The velocity structure is generally heterogeneous with both low and high velocities at upper crustal depths. Along the East Anatolian Fault Zone and its environs, low-velocity anomalies are charted. Also, small b-values (<1.0) are estimated in the region encompassing the KMES, especially at upper crustal depths. The KMES source zone is characterized by low b-value, low to average Vp, low Vs, and average/high Vp/Vs ratios. Hit count rates and the resolution test show that the mapped velocity anomalies are robust down to a depth of 45 km. Therefore, the moderate/high Vp/Vs and small b-values at the upper and middle crustal depths along the EAFZ may give constraints on the next earthquake hazards of the study region. The present findings provide deeper insight into the physical properties and the seismogenic potential of the crustal zones in proximity to the active fault segments of the Anatolian Plateau and the northwestern part of Arabia.

    AtıfScopus2WoS1OpenAlex1
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2026Scopus SJRQ1
    Influencer Authenticity in Marketing: A Systematic Literature Review and Future Research Agenda

    Celik, Fatih; Ibrahim, Blend; Polat, Eray; Moulard, Julie; Akbulut, Metin

    As influencer marketing scales into a mainstream advertising channel, authenticity has become its defining currency, yet consumers and brands struggle to understand what makes a social media influencer (SMI) genuinely credible and why strategic authenticity backfires. Despite growing scholarly interest, research remains fragmented, leaving practitioners without a unified framework to guide their decisions. Through a systematic literature review (SLR) of 138 peer-reviewed articles (2011-2024), using topic modeling and thematic analysis, we identify the authenticity paradox, the inherent conflict that arises when SMIs attempt to commercialize their genuine self-presentation. This tension also explains why recent evidence reports no overall engagement benefit from perceived authenticity. Seven latent topics are synthesized into four integrated axes: (1) ontological tensions at the technological interface, (2) the commercial transparency and trust paradox, (3) ethical negotiation in identity construction, and (4) strategic consumer responses. Our findings reveal how consumers continuously navigate between SMIs' curated performances and perceived genuineness, with self-determination theory, attribution theory, and parasocial interaction theory dominating current explanations, predominantly within USA-based contexts. Beyond mapping the field, we specify three conceptual patterns, namely authenticity as attributed intent, transparency as coherence rather than concealment, and authenticity as a structurally constrained accomplishment. We then translate the gaps they expose into a structured research agenda, offering actionable insights for brands, managers, and platform designers on authenticity management, influencer selection, partnership governance, and performance evaluation.

  • MakaleAçık Erişim2026Scopus SJRQ1
    Effects of Halotherapy as an Adjunct to Preseason Training on Respiratory and Aerobic Outcomes in Elite Female Football Players: A Randomized Controlled Trial

    Sarisik, Derya Cetin; Aydin, Ahmet Serhat; Söyler, Mehmet; Zileli, Raif; Özkurt, Ali; Yilmaz, Coskun; Küçük, Hamza; Karatas, Mevlut

    Background: Aerobic capacity and respiratory efficiency are critical determinants of performance in elite female football, characterized by repeated high-intensity efforts and rapid recovery demands. Halotherapy, involving the inhalation of dry salt aerosol, has been shown to improve pulmonary health; however, its effects on exercise-related outcomes in athletic populations remain insufficiently investigated. This study aimed to examine the effects of a 12-week post-training halotherapy intervention on respiratory muscle strength, pulmonary function, and aerobic performance in elite female football players. Methods: Twenty-eight elite female football players competing in the Turkish Women's First League were randomly assigned to a halotherapy group (HG, n = 14) or a control group (CG, n = 14). Both groups completed an identical preseason training program, while the HG additionally performed 45 min halotherapy sessions three times per week in a controlled halochamber. Pre-and post-intervention assessments included maximal inspiratory and expiratory pressures (MIP, MEP), spirometric parameters (FVC, FEV1, PEF, MVV), and maximal oxygen uptake (VO(2)max) estimated using the Yo-Yo Intermittent Recovery Test Level 1 (Yo-Yo IRT1), along with total distance covered. A 2 & times; 2 mixed-model ANOVA was used to assess time and group & times; time interaction effects. Results: Significant group & times; time interactions were observed for MIP, MEP, VO(2)max, FEV1, PEF, MVV, and Yo-Yo IRT1 performance (p < 0.05), with large effect sizes (eta p(2) = 0.269-0.924), favoring the halotherapy group. Forced vital capacity (FVC) increased over time in both groups (p = 0.141), with no significant interaction effect. Changes in the control group were comparatively smaller across most outcomes. Conclusion: Post-training halotherapy was associated with improvements in respiratory muscle strength, ventilatory function, aerobic capacity, and intermittent running performance in elite female football players. These findings suggest that halotherapy may be considered as a complementary, non-invasive strategy to support respiratory and aerobic adaptations. Further research is required to confirm these findings and to clarify the underlying physiological mechanisms. Trial registration: NCT07406386; 6 February 2026.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
  • MakaleAçık Erişim2026Scopus SJRQ1
    Effects of psychological skills training on self-control, perceived physical self-defense capacity, and mental toughness in elite female wrestlers: a randomized controlled trial

    Tutal, Varol; Demir, Okan; Sahin, Oktay; Albayrak, Ahmet Yilmaz; Bayansalduz, Mehmet; Uzun, Recep Nur; Öz, Faik; Sahinler, Yunus; Ceylan, Levent; Yilmaz, Coskun

    Background Self-control, self-defense self-efficacy, and mental resilience are fundamental psychological determinants of performance and competitive endurance in combat sports. However, scientific evidence on structured, evidence-based psychological intervention programs for professional female wrestlers remains limited. This study examined the effects of a psychological skills training (PST)-based intervention on self-control, self-defense self-efficacy, and mental resilience in professional female wrestlers. Methods A randomized controlled pre-test-post-test design was employed. Thirty-six professional female wrestlers (aged 18-25) were randomly assigned to a PST group (n = 18) or a control group (CG; n = 18). The PST group completed an 8-week structured psychological intervention alongside regular training, while the CG continued routine training only. Self-control, self-defense self-efficacy, and mental resilience were assessed pre-and post-intervention using valid and reliable psychometric scales. Data were analyzed via repeated-measures ANOVA, with effect sizes calculated. Results Significant group & times; time interactions were observed across multiple outcomes. A highly significant interaction emerged for perceived physical self-defense capacity (SP; F(1,34) = 56.525, p < 0.001, eta p(2) = 0.624) and for DP scores (F (1,34) = 9.360, p = 0.004, eta p(2) = 0.216). Among self-control subscales, significant interactions were found for inhibition (F (1,34) = 8.172, p = 0.007, eta p(2) = 0.194) and, more strongly, for initiation (F (1,34) = 14.157, p < 0.001, eta p(2) = 0.294). For mental resilience, highly significant interactions were detected for confidence (F (1,34) = 59.976, p < 0.001, eta p(2) = 0.638), control (F (1,34) = 32.486, p < 0.001, eta p(2) = 0.489), and persistence (F (1,34) = 32.709, p < 0.001, eta p(2) = 0.490). Overall, the intervention demonstrated medium-to-high effect sizes across psychological performance indicators. Conclusion These findings suggest that PST may serve as a useful complementary approach for enhancing self-control, perceived physical self-defense capacity, and mental toughness in professional female wrestlers. However, results should not be interpreted as evidence of improved competitive wrestling performance, technical success, or objectively measured physical self-defense ability, as these outcomes were not directly assessed in this study.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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    Web of SciencePubMedİncele