Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Acet, Tuba(7)
- Özcan, Kadriye(5)
- Akar, Zeynep(3)
- Topal, Fevzi(3)
- Burnaz, Nesibe Arslan(2)
- Cetiz, Mehmet Veysi(2)
- Deniz, Ilhan(2)
- Gulcin, Ilhami(2)
- Gülçin, İlhami(2)
- Küçük, Murat(2)
- Okan, Onur Tolga(2)
- Topal, Meryem(2)
- Yagi, Sakina(2)
- Yapici, Ismail(2)
- Yapıcı, İsmail(2)
- Yildiztugay, Evren(2)
- Zehiroğlu, Cuma(2)
- Zengin, Gokhan(2)
- Çorbacı, Cengiz(2)
- Öztürk Sarıkaya, Sevim Beyza(2)
- İzol, Ebubekir(2)
- Abdullah Yilmaz, Mustafa(1)
- Abdullah Yılmaz, Mustafa(1)
- Akar, Bulent(1)
- Akar, Bülent(1)
- Akaydin, Y(1)
- Akgul, Bengusu Hacer(1)
- Aksakal, A.(1)
- Aktürk, Betül Kara(1)
- Akıl, Fatoş(1)
- Arslan Burnaz, Nesibe(1)
- Ataş, Mehmet(1)
- Atıcı, Ökkeş(1)
- Aydın, İhsan(1)
- Aykoc, Ayse Muslu(1)
- Aysu, Şühedanur(1)
- Balci, Neslihan(1)
- Balcı, Neslihan(1)
- Baltaci, Cemalettin(1)
- Baltacı, Cemalettin(1)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ3Impacts of Phenolic Compounds Alone and in Combination with Natural Substances or Drugs on Cancer Cells
Budak, Burhan; Sarikaya, Sevim Beyza Ozturk
Phenolic compounds (PCs) are secondary metabolites found in the root and flower parts of plants that help protect the plant from pathogens. The amount and content of the plant species and the environment in which they live vary. Because PCs have antioxidant properties, they have a preventive effect against oxidising substances. Therefore, PCs in the human diet contribute to the prevention of cancer, osteoporosis, diabetes, and many other diseases. Cancer is the most dangerous and deadly disease among these diseases today. Although many chemotherapeutic drugs are used against cancer, the tendency to use other drugs or other applications has increased because the effectiveness of chemotherapeutic drugs is low and healthy cells are damaged in the process. PCs boost the effectiveness of chemotherapeutic drugs against cancer cells while, preserving the health of other cells. In this review, in vivo and in vitro studies conducted in cancer lines, applications of PCs alone, combined applications of PCs with natural substances, and the effects of PCs with drugs were investigated and discussed. In conclusion, gallic acid, ellagic acid, caffeic acid, and ferulic acid are frequently used in cancer treatment. These findings highlight the potential of PCs as versatile adjuvants in cancer treatment, which can increase drug efficacy, protect healthy cells, and minimise toxicity. Consequently, they highlight the therapeutic potential of PCs as complementary agents in cancer treatment strategies.
AtıfOpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ1Physicochemical properties of fifteen flower honey samples from five districts in Türkiye
Ucuncu, Osman; Kul, Merve Kalafat; Baltaci, Cemalettin; Aykoc, Ayse Muslu
This study analyzed the physicochemical characteristics, mineral composition, and antioxidant potential of fifteen floral honey samples collected from five districts of Gümüşhane, Türkiye. The average values for moisture (17.44 g/100 g), insoluble solids (0.04 g/100 g), conductivity (0.35 mS/cm), diastase activity (54.15 DN), free acidity (38.18 meq/kg), and fructose + glucose content (68.95 g/100 g) were mostly within the acceptable limits defined by national honey standards. Proline content ranged from 562.66 to 1466.15 mg/kg, while hydroxymethylfurfural (0.37–18.89 mg/kg) confirmed the freshness of all samples. Potassium, calcium, sodium, and magnesium were identified as the major mineral elements in the analyzed honey samples, with considerable variation observed among samples collected from different districts. Antioxidant activity (Total phenolic content (mg GAE/100 g): 9.21–98.25; SC₅₀ (mg/mL): 5.23–41.29) revealed a strong antioxidant potential of Gümüşhane honeys. This work provides the first detailed characterization of Gümüşhane honeys, confirming their high physicochemical quality, rich mineral profile, and notable antioxidant potential, and underscores their value as a distinctive regional product with functional and commercial significance.
AtıfScopus4WoS5İncele - MakaleYalnız künye2026Scopus SJRQ1Chemical characterization and bioactivity assessment of Erodium cedrorum subsp. salmoneum extracts supported by in silico analysis
Yagi, Sakina; Zengin, Gokhan; Zoltan, Cziaky; Jeko, Josef; Ivashchanka, Yahor; Turecka, Katarzyna; Halasa, Rafal; Gucwa, Magdalena; Kochan-Jamrozy, Kinga; Stefanowicz-Hajduk, Justyna
The growing interest in natural products, particularly as food additives and pharmaceutical raw materials, is making research into discovering new sources especially important. Erodium cedrorum subsp. salmoneum (family Geraniaceae) is used traditionally to cure many ailments like diabetes and gastro-intestinal diseases. Within this background, the current study was designed to investigate, for the first time, the chemical composition, antioxidant and enzyme inhibitory poroperties of different extracts from the aerial parts and roots of E. cedrorum. Results revealed that the aqueous extract of the aerial parts accumulated the highest total phenolic (85.35 mg GAE/g) and flavonoids (28.65 mg RE/g) contents. A total of 61 and 45 compounds, belonging mainly to phenolic acids and flavonoids, were tentatively identified in the aerial parts and roots extracts respectively. The aqueous extract from the aerial parts exerted the highest antiradical, ions reducing and chelation properties. The EtOH and 70% EtOH extracts of the two organs recorded the best anti-acetylcholinesterase activity (2.18 -2.41 mg GALAE/g; p >= 0.05) while those of the roots recorded respectively the best anti-butyrylcholinesterase and antityrosinase activities. The most potent antibacterial activity was exhibited by the 70% EtOH extracts from aerial parts and the pure EtOH extracts from roots. In contrast, ethyl acetate extracts from both plant parts showed only marginal activity. Among the tested strains, the highest susceptibility was observed against C. sporogenes ATCC 19404, C. bifermentans ATCC 638, S. aureus ATCC 6538, S. aureus ATCC 43300 (MRSA), C. diphtheriae PCM 506, and H. pylori ATCC 43504. The extracts were also examined for their anti-cancer potential on the HeLa, AGS and SKOV-3 cell lines, as well as a non-cancerous cell line. The ethyl acetate extract of the roots exhibited the most potent anti-cancer activity, with the lowest IC50 values. In addition, selected top-ranked complexes against AChE, alpha-amylase, representative bacterial and oncogenic targets were further evaluated by molecular docking and 100 ns molecular dynamics (MD) simulations, indicating overall conformational stability and persistent binding. In conclusion, these results position E. cedrorum as a valuable natural source of antioxidant and enzyme-inhibitory agents, meriting further exploration for drug development purposes.
AtıfScopus1WoS2OpenAlex2İncele - MakaleAçık Erişim2026Scopus SJRQ2Chemical Constituents and Biological Potentials of Teucrium scordium subsp. scordioides Extracts: In Vitro Experimental and In Silico Perspectives
Akgul, Bengusu Hacer; Yagi, Sakina; Cetiz, Mehmet Veysi; Saka, Enver; Zengin, Gokhan; Llorent-Martínez, Eulogio J.; Gómez-Torres, Marina; Yapici, Ismail; Gulcin, Ilhami; Yildiztugay, Evren
This study was undertaken to examine, for the first time, the antioxidant and enzyme inhibitory properties of several extracts obtained from the aerial parts of Teucrium scordium subsp. scordioides (Schreb.) Arcang (family: Lamiaceae). Among the extracts, the EtOH extract contained the highest total phenolic (89.96 mg GAE/g) and flavonoid (45.74 mg RE/g) contents. Phenylethanoid glycosides were predominant, particularly in the ethanol and aqueous extracts, and teucroside/forsythoside B and verbascoside/forsythoside A were tentatively identified as the major compounds. EtOH and 70% EtOH extracts showed comparable (p > 0.05) anti-DPPH activity (201.89 and 188.52 mg TE/g), Cu++ (562.81 and 547.88 mg TE/g), and Fe+++ (329.13 and 320.08 mg TE/g) reducing capacities. The EtOH extract showed the best antityrosinase activity (72.00 mg KAE/g). The EtOAc extract inhibited human carbonic anhydrase (CA) isoenzymes I and CAII (IC50 = 26.86 and 65.37 mu g/mL, respectively). Complementary in silico analyses of the major phenylethanoid and flavonoid glycosides supported their possible multitarget interaction patterns and identified the Forsythoside A-BChE complex as a computationally favorable model for future experimental validation. Overall, these findings indicate that T. scordium subsp. scordioides may represent a natural source of antioxidants and enzyme inhibitors for use in different health-promoting formulations.
- MakaleAçık Erişim2025Scopus SJRQ2Research of Peganum harmala: Phytochemical Content, Mineral Profile, Antioxidant, Antidiabetic, Anticholinergic Properties, and Molecular Docking
İzol, Ebubekir; Turhan, Münire; Yapıcı, İsmail; Necip, Adem; Abdullah Yılmaz, Mustafa; Zengin, Gökhan
Peganum harmala is a significant medicinal, aromatic plant used in traditional medicine and the subject of many studies. In this study, the phytochemical compound and mineral profile of the plant's ethanol extract were identified quantitatively. Antioxidant properties were determined by total phenolic and flavonoid content, FRAP, DPPH, CUPRAC, ABTS, metal chelating, and phosphomolybdenum assays. Antidiabetic, anticholinergic, and skin care properties were specified by the inhibition of tyrosinase, α-glucosidase, α-amylase, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) enzymes, respectively. In addition, binding interactions of major phytochemicals with all enzymes were investigated by molecular docking studies. The phytochemical compound of the extract contained significant bioactive components such as acacetin, gentisic acid, p-coumaric acid, quinic acid, rutin, apigenin, and chrysin, while the mineral profile was rich in salt elements. AChE, BChE, tyrosinase, α-amylase, and α-glycosidase enzyme inhibitor results were determined as 2.99 mg GALAE/g, 4.14 mg GALAE/g, 35.8 mg KAE/g, 2.76 mmol ACAE/g, and 1.20 mmol ACAE/g, respectively. As a result, it was identified that it had antioxidant properties and strongly inhibited all enzymes except tyrosinase. The docking scores of major bioactive phytochemicals were found to be high. The best binding pose was obtained by docking acacetin into the active site of AChE (PDB: 4EY7), BChE (PDB: 4BDS), α-glucosidase (PDB: 3WY1), α-amylase (PDB: 6GXV) and tyrosinase (PDB: 2Y9X) receptors. Docking score values were calculated as −10.4, −9.2, −8.8, −7.8, and −7.4 kcal/mol, respectively. Thus, it was revealed that P. harmala has an important potential in drug research and treatment of some diseases.
AtıfScopus14WoS13OpenAlex18İncele - MakaleYalnız künye2025Scopus SJRQ3Inhibition Effect of Cordyceps sinensis (C. sinensis) Mycelium on Some Metabolic Enzymes and Investigation of Antioxidant Properties
Balcı, Neslihan
Cordyceps sinensis (CS), a traditional medicinal fungus, is a rich source of bioactive metabolites with pharmacological potential. This study investigated the inhibitory effects of CS mycelium on human carbonic anhydrase isoenzymes I and II (hCA I and hCA II) and acetylcholinesterase (AChE), as well as its antioxidant properties. Enzyme inhibition was assessed using spectrophotometric methods, whereas antioxidant capacity was evaluated by DPPH, ABTS, CUPRAC, FRAP, and Fe3⁺-reducing assays. LC-MS/MS analysis identified key secondary metabolites, including apigenin, apigenin-7-glucoside, (+)-taxifolin, dihydrokaempferol, p-coumaric acid, salicylic acid, and L-theanine, with apigenin as the major constituent. CS strongly inhibited hCA I (IC50 = 1.11 µg/mL) and hCA II (IC50 = 1.77 µg/mL), exceeding the potency of acetazolamide, and also showed relevant AChE inhibition (IC50 = 8.00 µg/mL), comparable to tacrine. Antioxidant assays revealed moderate DPPH activity but strong ABTS and CUPRAC reducing capacities, indicating the structural contributions of flavonoids and phenolic acids. These findings suggest that CS possess dual bioactivity through enzyme inhibition and antioxidant effects, highlighting its therapeutic potential against neurodegenerative and oxidative stress–related diseases.
- MakaleAçık Erişim2025Scopus SJRQ4DYE REMOVAL PERFORMANCE AND BIOLOGICAL ACTIVITIES OF IRON OXIDE NANOPARTICLES SYNTHESIZED FROM Cotoneaster sp. FRUIT EXTRACT
Akar, Bülent; Baltacı, Cemalettin; Düzgün, Azer Özad; Karpuz, Omer; Karakullukçu, Volkan; Erdoğdu, Esma Gülbahar
This work aimed to study the antioxidant, antibacterial, and dye adsorption capabilities of the aqueous extract of Cotoneaster sp. fruits (CFE) and iron oxide nanoparticles (CF-FeONP) green-synthesized from the CFE. CF-FeONPs were characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD) analyses. The antioxidant activity of CFE and CF-FeONPs was assessed through various tests, including ABTS radical scavenging activity, DPPH radical scavenging activity, iron-reducing antioxidant power (FRAP), total phenolic content (TPC), total flavonoid content (TFC), and total antioxidant content (TAC). The CF-FeONPs had superior antibacterial and antioxidant activity compared to the CFEs. Furthermore, CF-FeONPs suppressed the growth of Gram-negative bacteria such as Yersinia pseudotuberculosis ATCC 911, Escherichia coli ATCC 25922, Proteus vulgaris ATCC 13315, and Pseudomonas aeruginosa ATCC 43288, as well as by Gram-positive bacteria like Streptococcus pyogenes ATCC 19615, Staphylococcus aureus ATCC 25923. and Bacillus subtilis ATCC 6633. The microdilution medium technique was used to determine the minimum inhibitory concentration (MIC) of CFE and CF-FeONPs against these bacteria strains. The adsorption rates of CF-FeONPs exhibited variability based on the quantity of adsorbent used and the specific dye type, whereas the lowest adsorption rate was 250 mg/L. CF-FeONPs demonstrated higher adsorption capacities for malachite green (MG) dye compared to methylene blue (MB) and phenol red (PR).
AtıfScopus2WoS2OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ2The biological activity and phenolic content of endemic Astragalus baibutensis
Ozcan, Kadriye; Acet, Tuba; Yiğittürk, Gürkan
Astragalus baibutensis, is a plant endemic to Turkey, belonging to Fabaceae family, that is used as a folk medicine and food in this country. The purpose of this study is to find out the biological activities such as antioxidant, antimicrobial, enzyme inhibitory and DNA protective activity and also analyse the phenolic contents of the plant. To determine of antioxidant activity ABTS and DPPH assays were performed. Disc diffusion and microdilution methods were used to evaluate the antimicrobial activity. Additionally, enzyme inhibitory activities such as α-amylase, α-glucosidase, and tyrosinase were determined by using spectrophotometric methods. DNA protective activity was detected using pUC19 Plazmid DNA. The antiproliferative effect on SKOV-3 human ovarian cancer cells was examined by WST-8 assay. In addition, the phenolic contents were analysed by using HPLC. The biological activity of ethyl acetate extract of the root was found to be higher than those of other extracts. This extract had the highest amount of apigenin as phenolic compound. On the other hand, extracts showed moderate inhibition against the tested microorganism and antiproliferative properties in a concentration-dependent manner toward ovarian cancer cells. According to the results, Astragalus baibutensis has the potential for pharmaceutical and food additive usage.
AtıfScopus1WoS1OpenAlex1İncele - MakaleYalnız künye2025Scopus SJRQ2Chemical Composition and Bioactivities of Sideritis libanotica Labill subsp. Libanotica: LC–HRMS Phytochemical Profiling, Mineral Content, Antioxidant, Antibacterial, and Neuroprotective–Antidiabetic Enzyme Inhibitory Potentials
Öztürk Sarıkaya, Sevim Beyza; Zehiroğlu, Cuma
Sideritis libanotica Labill. subsp. libanotica (SLL) is an herbal tea used for colds, coughs, and digestive system disorders. SLL has higher antioxidant activity in methods (µg/mL) like 1,1-diphenyl-2-picrylhydrazyl (DPPH•) (40.912 ± 0.170), ABTS•+ (14.61 ± 0.331) scavenging activity, and Fe3+ (0.872 ± 0.052) and Cu2+ (0.840 ± 0.013) reduction capacity compared to other Sideritis species. It is rich in essential minerals, such as Ca, Mg, and P, with the highest content of mineral K (14 203.97 mg/kg). Zone values in the range of 9–11 mm were obtained from Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Pseudomonas putida, and Klebsiella pneumoniae strains, which is an indicator that the plant has antibacterial activity. Among 33 secondary metabolites, sinapinic acid, rutin, and hispidulin have high values, whereas the one with the highest value is verbascoside (274 483 mg/kg), a pharmacologically active compound. It showed an inhibitory effect (mg/mL) on some enzymes targeting neurodegenerative and metabolic disorders. (IC50; acetylcholinesterase [AChE]: 0.065, butyrylcholinesterase [BChE]: 0.086, α-glucosidase: 0.014).
AtıfScopus1WoS1OpenAlex1İncele - MakaleYalnız künye2025Scopus SJRQ2Phenolic Profiles, Mineral Compositions, and Solvent-Driven Antioxidant Potentials of Two Robinia Species
Aktürk, Betül Kara; Arslan Burnaz, Nesibe
The genus Robinia, which belongs to the Fabaceae family, is a source of polyphenols and may be medicinally and pharmacologically effective against life-threatening diseases. This study investigated and compared the phenolic profiles, mineral contents, and antioxidant activities of two Robinia species. The antioxidant activities and phenolic/flavonoid contents of aerial parts of Robinia pseudoacacia and Robinia × ambigua plants at various solvents and concentrations were investigated in detail for the first time. The findings revealed that 50% acetone leaf extracts are promising sources of high phenol/flavonoid contents and antioxidant activity. Liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–ESI–MS/MS) analysis allowed the identification of nine flavonoids and seven phenolic acids. Pelargonidin chloride, a common anthocyanidin with estrogenic activity, was the major component in all samples. Moreover, inductively coupled plasma–mass spectrometry (ICP–MS) shows that all samples were rich in K (12 886.70–26 078.11 mg/kg), Ca (1550.51–6011.03 mg/kg), and Mg (1676.13–3115.10 mg/kg). Leaves stand out compared to flowers. It is considered that the results obtained may guide studies in the fields of medicine, cosmetics, pharmacology, and so forth.
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2025Inhibition Effect of Diosmin Flavanoid on Some Metabolic Enzymes and Investigation of Antioxidant Properties
Balci, Neslihan
Diosmin is a natural flavonoid obtained by dehydrating flavanone glycoside hesperidin. This study evaluated the inhibition effects of diosmin flavonoid on human carbonic anhydrases (hCA I and hCA II) and acetylcholinesterase (AChE) enzymes, which are linked to various health issues, and compared the results with standard drugs. The antioxidant potential was assessed using five assays, namely DPPH, ABTS, FRAP, CUPRAC and Fe3+ reducing assays. The results determined that diosmin didn’t exhibit strong antioxidant activity. Additionally, the inhibition effects of diosmin on hCA I, hCA II, and AChE enzymes were examined. It effectively inhibited hCA I and hCA II enzymes with Ki values of 3.84±0.63 nM and 15.64±1.90 nM, respectively (Table 1). For comparison, the Ki values of the standard drug AZA were 1.44 ± 0.32 nM for hCA I and 3.66 ± 0.25 nM for hCA II. On the other hand, diosmin effectively inhibited AChE enzymes with Ki values of 9.31±2.40 nM. The Ki values of the standard drug Tacrine was 6.22±1.95 nM for AChE. These findings suggest that diosmin may serve as a selective enzyme inhibitor, particularly for hCA I, but has limited antioxidant capacity. Diosmin exhibited relatively weak antioxidant activity compared to standard antioxidants.
- MakaleAçık Erişim2024Determination of Antioxidant Capacities of Extracts of Sorbus subfusca (ledeb. ex. nordm.) boiss
Kocabaş, Selahattin; Topal, Fevzi
Sorbus subfusca (ledeb. ex. nordm.) boiss. (Sorbus subfusca) belongs to the Rosacese family. It is commonly referred to as highland rowan. It is an endemic species found only in the eastern Black Sea Region of Turkey and in a few countries on the Asian Continent. Both water (WESS) and ethyl alcohol (EESS) lyophilized forms were used as extracts. Different reducing capacity methods and radical scavenging activity methods were used to study the antioxidant activities of the extracts. Total phenolic compounds were calculated as 43.5 (WESS) and 43.0 (EESS) µg GAE/mg extract. This value is an indication that it can take place in plants with high phenolic content. Peroxidation inhibition percentages of linoleic acid emulsion at 20 µg mL-1 concentration for WESS and EESS; WESS was calculated as 70.93% and EESS as 82.63%. The high antioxidant capacity of Sorbus subfusca, an endemic species, brings up the preference of natural products as antioxidants. It is thought that these studies will draw a new path to the literature, especially alternative medicine and pharmacological studies.
AtıfScopus1OpenAlex2TR Dizin1İncele - MakaleAçık Erişim2024Scopus SJRQ1Chemical Content by LC–MS/MS, Antiglaucoma, and Antioxidant Activity of Propolis Samples From Different Regions of Türkiye
İzol, Ebubekir; Bursal, Ercan; Yapıcı, İsmail; Abdullah Yilmaz, Mustafa; Yilmaz, İsa; Gülçin, İlhami
Propolis is a sticky substance produced by bees because of the reaction of beeswax, pollen, and bee enzymes. Particularly, their biological activity and chemical content attract attention. Thus, in this study, the total amount of phenolic and flavonoid substances, Fe3+-Fe2+, Cu2+ (cupric ions reducing activity [CUPRAC]), and Fe3+-TPTZ (ferric ions reducing antioxidant power [FRAP]) reducing, and DPPH• and ABTS•+ scavenging assays in vitro antioxidant properties of propolis samples obtained from four different provinces of Türkiye were determined. In addition, the chemical content of propolis samples was quantitatively determined by LC–MS/MS, and the antiglaucoma property was revealed by hCAII enzyme inhibition. Propolis samples from Ordu presented the highest amounts of total phenolic and flavonoid content (492.3 ± 5.8 and 96.1 ± 2.1, respectively) and also highest antioxidant activity (DPPH• and ABTS•+ IC50 [μg/mL]: 8.884 ± 0.84 and 4.589 ± 0.80, respectively; Fe+3, CUPRAC, and FRAP: 1.051 ± 0.012, 1.021 ± 0.008, and 0.957 ± 0.007 μg/mL, respectively). hCAII enzyme inhibition was highest in Muş propolis (IC50 [μg/mL]: 8.6) as determined. By LC–MS/MS, 53 different components were screened and 35 bioactive components were determined. According to the results, propolis was found to be a raw material because it contains high concentrations of acacetin, chrysin, caffeic acid, and quinic acid (123.824, 24.759, 47.779, and 16.32 mg analyte/g extract, respectively).
AtıfScopus15WoS15OpenAlex17İncele - MakaleAçık Erişim2024Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity
Topal, Meryem; Topal, Fevzi; Yilmaz, Fırat
In Kars-Sarıkamış-Soğanlı, Angelica purpurascens (A. purpurascens) emerges as a promising natural antioxidant source. Extracts from its leaves, branches, and flowers underwent thorough bioanalytical assessments. The leaf extract exhibited the highest concentrations of herbal flavonoids (45.22 µg QE/mg extract) and total phenolics (28.96 µg GAE/mg extract). Branch extracts demonstrated significant enzymatic activity against AChE and BChE with IC50 values of 37.26 mg/mL and 9.08 mg/mL respectively. The flower extract displayed notable antibacterial properties. This study sheds light on the therapeutic potential of A. purpurascens ethanol extracts, suggesting benefits for Alzheimer’s, cell damage-induced diseases, and diabetes mellitus. It pioneers new enzymatic and antioxidant insights and contributes to understanding this abundant Türkiye species. A. purpurascens holds promise for pharmaceutical exploration, offering potential solutions for challenging health conditions.
AtıfScopus1OpenAlex3TR Dizin2İncele - MakaleAçık Erişim2023Scopus SJRQ1The Comparison with Commercial Antioxidants, Effects on Colour, and Sensory Properties of Green Tea Powder in Butter
Çakmakçı, Songül; Gülçin, İlhami; Gündoğdu, Engin; Ertem Öztekin, Hatice; Taslimi, Parham
Oxidation is one of the most important factors limiting shelf life and is a major deterioration process affecting both the sensory and nutritional quality of food. The high oxidation stability of lipids, which can be improved by the addition of antioxidants, is important for health protection, food quality, and economic reasons. In recent years, research on plant-derived antioxidants for use in human health and food has steadily increased. The aim of this study was to compare the antioxidant effects of green tea powder (GTP) in butter with those of commercial antioxidants (BHA, BHT, α-tocopherol, and Trolox). In addition, the effects on colour, sensory, gross physicochemical properties, and β-carotene content were investigated in butter. After the separation of butter into five pieces, the first part was chosen as the control sample without GTP; the second part has 100 mg/kg of BHT added to it; and the third, fourth, and fifth parts had 1, 2, and 3% of GTP added in the samples. They were stored at 4 ± 1 °C. Analysis was performed at intervals of 15 days. According to the iron reduction, CUPRAC and FRAP methods were performed, and parallel results were observed. Using the radical elimination methods (ABTS, DPPH•, and DMPD•+), IC50 values were calculated for the samples. According to the IC50 values, the GTP-containing samples were good antioxidants. The total phenolic andf β-carotene contents increased as the GTP addition increased. The addition of GTP had an antioxidant capacity equal to or higher than that of the BHT-added sample. For the production of a sensory-pleasing, greenish-coloured, new functional butter, the 1% GTP addition showed the most positive results.
AtıfScopus18WoS17OpenAlex20İncele - MakaleYalnız künye2023Scopus SJRQ2Endemic Mountain Tea (Sideritis dichotoma Huter): Antioxidant and Antibacterial Activities, Mineral Content by ICP-MS and Phytochemical Content by LCHR-MS
Öztürk Sarıkaya, Sevim Beyza; Zehiroğlu, Cuma
Endemic Sideritis dichotoma Huter, herbal tea, is used for colds, coughs and digestive ailments. Since at least 25 % of the active ingredients of pharmacological drugs are obtained from plants, it is important to investigate many plants, both traditionally used and whose potential hasnt yet been discovered, before they disappear. When the results compared to other Sideritis species, it has better antioxidant activity in DPPH⋅ scavenging activity, Fe3+ and Cu2+ reducing capacity methods and is also rich in minerals, necessary for human body, K, Mg, Ca, P, S. Zone values (10–19,5 mm) obtained on S. aureus, P. aeruginosa, E. coli, S.enteritidis, E. faecalis, P. putida and K. pnemoniae strains are an indication that the plant has antibacterial activity. 27 secondary metabolites were identified by LC-HRMS. Verbascoside, pharmacologically active compound known to have antitumor effect, cytotoxic selectivity and anticancer activity, is the most abundant phenolic in ethanol extract (49297.13 mg/kg).
AtıfScopus7WoS6OpenAlex8İncele - MakaleYalnız künye2022Scopus SJRQ3Development of Homemade Hazelnut Milk-based Beverage
Aysu, Şühedanur; Akıl, Fatoş; Çevik, Edanur; Kılıç, Mustafa Emin; İlyasoğlu, Huri
A homemade hazelnut milk-based beverage was prepared from hazelnut milk with raisins. The proximate composition, physicochemical and sensorial properties, total phenolic content (TPC), antioxidant activity, and fatty acid compositions of the beverage samples were determined. The properties of the three different preparations of homemade hazelnut milk with raisins (1%, 3%, and 5%) were compared with the control sample without raisins. The main macronutrient was fat (6.3‒7.3%) in the hazelnut milk beverage followed by carbohydrate (3‒3.5%) and protein (2.2‒2.5%). The addition of raisins to the beverage formulation increased the flavor and general acceptability scores. It also improved the TPC and antioxidant capacity. The TPC of the developed beverage samples ranged from 65 to 97 mg/L. The fatty acid composition was rich in monounsaturated fatty acids as mainly oleic acid (>80%). The hazelnut milk beverage may have potential as a functional beverage in a daily diet to provide nutrients and energy.
AtıfScopus15WoS12OpenAlex16İncele - MakaleYalnız künye2022Scopus SJRQ2Chemical profile, antioxidant, antimicrobial, and enzyme inhibition activities of Pilosella hoppeana subsp. cilicica
Acet, Tuba
Pilosella hoppeana subsp. cilicica has been traditionally used for healing many diseases in folk medicine in Anatolia. However, there are, to date, no studies aimed to verify this local usage with scientific data. In the present study, phenolic content and biological activities such as the antioxidant, antimicrobial and enzyme inhibition activities of different extracts of this plant’s aerial part were investigated for the first time. According to the obtained data, the biological activity of methanol extract was found to be significantly higher than the others. Moreover, the major components detected were chlorogenic acid (61.79 mg g−1 extract), apigenin (2.727 mg g−1 extract), and luteolin (1.110 mg g−1 extract) in this extract. This extract showed a strong enzyme inhibitory activity including α-amylase (96.66 mmol ACAE g−1 extract), α-glucosidase (17.27 mmol ACAE g−1 extract), AChE (10.42 mg GALE g−1 extract), and BChE (102.35 mg GALE g−1 extract). On the other hand, the extract exhibited remarkable antimicrobial effect on Yersinia pseudotuberculosis, and Staphylococcus epidermidis (64 µg/mL MIC value); intermediate (128–256 µg/mL MIC value) antimicrobial activity on Proteus vulgaris, Listeria innocua, and vancomycin-resistant Enterococcus faecium. To sum up, it is clearly seen that Pilosella hoppeana subsp. cilicica has significant potential as a source of bioactive compounds in pharmaceutical industries.
AtıfScopus3WoS3OpenAlex5İncele - MakaleAçık Erişim2022Scopus SJRQ2Investigation of the effects of different extraction methods on some biological activities of Dactylorhiza romana subsp. georgica (Klinge) Soó ex Renz & Taubenheim
Bozkir, Buğra; Acet, Tuba; Özcan, Kadriye
Dactylorhiza romana subsp. georgica is found in Anatolia and is traditionally used by local people both as food and to alleviate various ailments. Although various biological activities of the plant have been partially investigated, these properties have not been comprehensively revealed in the light of scientific data. In this study, it was aimed to elucidate the antioxidant, antimicrobial, enzyme inhibition (alpha amylase, alpha glucosidase, and tyrosinase) and DNA protective activity and phenolic content of the extracts obtained from orchid tubers using different extraction methods. For this, the fresh and dry tubers of the plant were extracted with ethanol at different times in an ultrasonic water bath, shaker and their combinations with each other. ABTS, DPPH, and FRAP methods were used to determine the antioxidant properties of plant tubers. In addition, the phosphomolybdate method was used to determine the total antioxidant capacity. The spectrophotometric method was preferred to reveal the enzyme inhibition activity. The antimicrobial activity of the extracts was investigated by microdilution method. In addition, the phenolic content of the plant was analysed by HPLC. The DNA protective activity of the extracts was determined by using the pUC 19 plasmid. According to the results obtained, it was revealed that each extract exhibited various biological activities. According to the HPLC results, the highest phenolic component in the extracts was determined as p-hydroxybenzoic acid. As a result, it was observed that the biological activities of orchid tubers changed according to different extraction methods. Accordingly, due to the high biological activities of orchid tubers, they have a high potential for use in the food and pharmaceutical industries.
AtıfScopus4WoS3OpenAlex5İncele - MakaleAçık Erişim2021Scopus SJRQ3Tarragon (Artemisia dracunculus l.) could alleviate negative effects of stocking density in laying hens
Kaya, H.; Karaalp, M.; Kaynar, Ö.; Tekçe, E.; Aksakal, A.; Bayram, B.
The study was conducted to determine the effects of stocking density (SD, 5 or 7 layers/cage) and tarragon (Artemisia dracunculus L.) diet supplementation at four levels (0, 1.2, 6 and 12 g/kg feed) on performance, certain egg characteristics, serum, liver, egg yolk and small intestine bacteria parameters in laying hens. The experiment was carried out over a period of 8 weeks, with 192 Lohman Brown commercial hybrids at 50-w-age. The results showed that an increased SD reduced feed intake (FI; p<0.01) and egg production (p<0.05), but had no effect on the weight gain, feed conversion ratio, damaged egg ratio, egg weight and egg quality (p>0.05) parameters. The supplementation of tarragon to the diet reduced the FI and damaged egg ratio (p<0.01), and improved egg production and FCR (p<0.01). While an increased SD reduced serum total antioxidants (p<0.05), it elevated corticosterone (CORT) and total oxidant serum (TOS) (p<0.05). Tarragon was found to enhance total immunoglobulin (p<0.05), but to decreased the CORT and TOS of the serum (p<0.05). An increased SD raised the malondialdehyde (MDA) in the serum (p<0.001), liver (p<0.05) and yolk (p<0.001). Tarragon supplementation reduced MDA of the serum (p<0.05), liver (p<0.001) and yolk (p<0.001). E. coli and total Mesophilic Aerobic Bacteria counts in the small intestine were raised (p<0.001) with increased SD. Tarragon decreased (p<0.05) mesophilic aerobic bacteria. It was thus found that, tarragon supplementation can be considered generally effective in improving performance parameters, alleviating stress-induced negativities, reducing lipid peroxidation, regulating the immune system and controlling some intestinal microorganisms.
AtıfScopus11WoS10OpenAlex10İncele