Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(66)
- Merdan, Mehmet(56)
- Duran, Celal(50)
- Ozdes, Duygu(47)
- Kaygusuz, Abdullah(42)
- Demir, Selim(37)
- Turan, Ibrahim(37)
- Ashyralyyev, Charyyar(34)
- Dokuz, Abdurrahman(33)
- Araz, Onur(31)
- Öztürk, Serkan(31)
- Sipahi, Ferkan(30)
- Kandemir, Raif(28)
- Arslan, Mehmet(27)
- Karsli, Orhan(27)
- Kulakaç, Nurşen(26)
- Baltacı, Cemalettin(25)
- Gücer, Mehmet Ali(25)
- Kurt, Kemal(25)
- Maden, Nafiz(25)
- Ozturk, Samet(25)
- Topal, Fevzi(25)
- Baltaci, Cemalettin(24)
- Yücel, Cem(24)
- Aliyazicioglu, Yuksel(23)
- Bayrakdaroglu, Serdar(23)
- Kankal, Murat(23)
- Peker, Iskender(23)
- Yolcu, Halil(23)
- Reis, Hatice Catal(21)
- Topal, Meryem(21)
- Vural, Alaaddin(21)
- Aydin, Aydanur(20)
- Aydin, Faruk(20)
- Bayraktar, Alemdar(20)
- Kurnaz, Muammer(20)
- Çelik, Necati(20)
- Ürkek, Bayram(20)
- Cakir, Tufan(18)
- Günen, Mehmet Akif(18)
Yayınlar
- MakaleYalnız künye2016Scopus SJRQ2Investigation of the quality and physical-geochemical characteristics of the drinking water in Gümüşhane (Turkey) city central
Sipahi, Ferkan; Uslu, Sultan
The physical (turbidity, color, smell, taste, pH, and conductivity) and geochemical properties (Ca, Mg, Na, Fe, Mn, Al, K, Cl−, HCO3 −, SO4 2−, Fe, Cu, Co, Ni, Zn, Cd, Pb, and Cr) of the drinking water in Gümüşhane city center were determined. This city center constitutes the study area. The pH levels of the water samples ranged from 6.3 to 8.2, and their conductivities ranged between 240 and 900 μS. These findings were concordant with the drinking water standards of the Turkey Standard Institute and the World Health Organization. The hardness of the water samples in the study area was between 18.1 and 115.1 °Fr. These samples were classified as extremely hard, hard, and quite hard. In addition, an assessment using the criteria for Inland Surface Water Classification indicated that considering certain parameters (pH levels, amount of Na, SO4 2−, Fe, Mn, Al, Co, Ni, Cu, and Cr), the samples belonged to class I (high quality) water. When Cl− amount and conductivity were considered, the samples belonged to the first and second classes (less polluted) of water. The water in the study area was generally classified as carbonated and sulfated (Ca + Mg > Na + K) water classes. This water contained more weak acids than strong acids (HCO3 − + CO3 2− > Cl− + SO4 2−). The pH levels (6.3–8.2) of the water in the study area were unrelated to the varying concentrations of metals in the water. Elements such as Fe, Ni, Cd, Pb, Zn, and Cu increase in the water through the water–rock interaction in the area in which water rises or through the mixture of water with either mine or industrial wastes. In addition, several water samples belonged to an acceptable water class for drinking and usage.
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İncele - MakaleYalnız künye2016Scopus SJRQ3The Effect of Dy Doping on the Magnetic Behavior of YBCO Superconductors
Öztürk, Ali; Doğan, Mustafa; Düzgün, İbrahim; Çelebi, Selahattin
The effect of dysprosium (Dy) doping on yttrium barium copper oxide (YBCO) prepared by conventional solid-state reaction method has been investigated by means of XRD, AC susceptibility, and DC magnetization measurements. AC susceptibility measurements for sintered YBCO pellets have been performed as a function of temperatures at constant frequency and AC field amplitude in the absence of a DC bias field. DC magnetization measurements were done at 5, 20, and 77 K upon zero field cooling (ZFC) process. The magnetization measurements showed a paramagnetic behavior existing at high magnetic fields. The magnetic field dependence of critical current density of the samples has been estimated from DC magnetization data. The partial Dy substitution for Y on YBCO superconductors improves the bulk critical current density at high magnetic fields and at high-temperature regions (higher than 20 K).
AtıfScopus18WoS15OpenAlex16İncele - MakaleYalnız künye2016Scopus SJRQ2The investigation of adhesion and fatigue properties of TiN/TaN multilayer coatings
Baran, Ö.; Sukuroglu, E.E.; Efeoglu, İ.; Totik, Y.
TiN/TaN multilayer coatings exhibit excellent mechanical properties when compared to single layer nitride coatings. In this study, TiN/TaN multilayer coatings were deposited on Mo-alloy and W-alloy substrates by CFUBMS. The structural and mechanical properties of coatings were analysed using XRD, EDS, SEM and a micro-hardness tester, respectively. To determine the adhesion and fatigue behaviour of the coatings were performed a scratch test in two modes that a standard mode with progressive loading and sliding-fatigue multimode operation with unidirectional sliding, respectively. A microscope was used to characterize adhesion and fatigue failures. The structural, mechanical, adhesion and fatigue properties of TiN/TaN multilayer coatings significantly changed depending on the substrate.
AtıfScopus14WoS12OpenAlex13İncele - MakaleAçık Erişim2016Scopus SJRQ2Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.)
Topal, Meryem; Gocer, Hulya; Topal, Fevzi; Kalin, Pinar; Köse, Leyla Polat; Gulçin, Ilhami; Çakmak, Kader C.; Küçük, Murat; Durmaz, Lokman; Gören, Ahmet C.
Cynarin is a derivative of hydroxycinnamic acid and it has biologically active functional groups constituent of some plants and food. We elucidated the antioxidant activity of cynarin by using different in vitro condition bioanalytical antioxidant assays like DMPD•+, ABTS•+, DPPH• and H2O2 scavenging effects, the total antioxidant influence, reducing capabilities, Fe2+ chelating and anticholinergic activities. Cynarin demonstrated 87.72% inhibition of linoleic acid lipid peroxidation at 30 g/mL concentration. Conversely, some standard antioxidants like trolox, tocopherol, butylated hydroxytoluene (BHT), and butylated hydroxyanisole (BHA) exhibited inhibitions of 90.32, 75.26, 97.61, 87.30%, and opponent peroxidation of linoleic acid emulsion at the identical concentration, seriatim. Also, cynarin exhibited effective DMPD•+, ABTS•+, DPPH•, and H2O2 scavenging effects, reducing capabilities and Fe2+ chelating effects. On the contrary, IC50 and Ki parameters of cynarin for acetylcholinesterase enzyme inhibition were determined as 243.67 nM (r2: 0.9444) and 39.34 ± 13.88 nM, respectively. This study clearly showed that cynarin had marked antioxidant, anticholinergic, reducing ability, radical-scavenging, and metal-binding activities.
AtıfScopus169WoS156OpenAlex169
İncele - MakaleYalnız künye2016Scopus SJRQ1Structure and surface properties of Al2O3–TiO2 ceramic coated AZ31 magnesium alloy
Çelik, İlhan
Magnesium and its alloys are the engineering materials which have the potential ability to be able to used widely particularly in the automotive, aerospace and in the biomedical sectors, especially thanks to their features such as lightness, specific strength that they have and biocompatibility. However, due to their poor wear resistance and corrosion resistance, the areas of usage are being restricted. This situation prevents Mg alloys to be used without any surface protection despite their good mechanical properties such as high strength/weight ratio. In this study, plasma spraying method is used to improve the poor corrosion resistance of AZ31 Mg alloy. Al2O3–13 wt% TiO2 (AT13) and Al2O3–40 wt% TiO2 (AT40) composite ceramic coatings were coated successfully on the surfaces of AZ31 Mg samples. The wear properties of the AT13 and AT40 coated samples were investigated for tribological applications. Surface morphology and microstructure of the duplex treated samples were analyzed by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The microhardness value of the uncoated AZ31 Mg alloy is 40±3 HV0.1, while the microhardness values of the AT40 and AT13 coatings are enhanced to 800±39 HV0.1 and 1500±35 HV0.1, respectively.
AtıfScopus58WoS54OpenAlex57İncele - MakaleAçık Erişim2016Scopus SJRQ1Comparison of verona integron-borne metallo-β-lactamase (VIM) variants reveals differences in stability and inhibition profiles
Makena, Anne; Düzgün, Azer Ö.; Brem, Jürgen; McDonough, Michael A.; Rydzik, Anna M.; Abboud, Martine I.; Saral, Ayşegül; Çiçek, Ayşegül Č.; Sandalli, Cemal; Schofield, Christopher J.
Metallo-β-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution of variant MBLs. The Verona integron-borne metallo-β-lactamase (VIM) enzymes are among the most widely distributed MBLs, with>40 VIM variants having been reported. We report on the crystallographic analysis of VIM-5 and comparison of biochemical and biophysical properties of VIM-1, VIM-2, VIM-4, VIM-5, and VIM-38. Recombinant VIM variants were produced and purified, and their secondary structure and thermal stabilities were investigated by circular dichroism analyses. Steady-state kinetic analyses with a representative panel of β-lactam substrates were carried out to compare the catalytic efficiencies of the VIM variants. Furthermore, a set of metalloenzyme inhibitors were screened to compare their effects on the different VIM variants. The results reveal only small variations in the kinetic parameters of the VIM variants but substantial differences in their thermal stabilities and inhibition profiles. Overall, these results support the proposal that protein stability may be a factor in MBL evolution and highlight the importance of screening MBL variants during inhibitor development programs.
AtıfScopus45WoS42İncele - BildiriAçık Erişim2016Scopus SJRQ4Assessment of sessile oak (quercus petraea L.) leaf as bioindicator for exploration geochemistry
Vural, A.
The element contents of sessile oak (Quercus petraea L.) leaves which grow on hydrothermally altered area with high element contents were studied at Gümüshane and its near vicinity. The aim of this study is to determine threshold element contents of Q. petraea L. leaves growing on the area. For this purpose, oak leave samples collected were analyzed by inductively coupled plasma-mass spectrometry for concentrations of some elements which were the group of most common trace elements in exploration geochemistry studies. The assessment of the element contents of the oak leaf is based on the descriptive statistics and computations of threshold values of leaves depending on statistical parameters and average element contents of the plants growing on lands in normal background values for the elements. According to Q-Q (normal quantile-quantile) plots, the Kolmogorov-Smirnov tests etc., all the elements, do not pass normality tests. Because of that, threshold values of the elements in leaves of oak were computed by median+median absolute deviation (MAD) and median+2MAD used in raw values for the elements. The data revealed that concentration levels of the examined elements in the leaves in the study area were determined as above and/or exceeded the upper limit of the normal range than in leaf of oak (Q. petraea L.) which grows on lands with normal elements background. Therefore, it is concluded that leaves of Q. petraea L. can be used as bioindicator in exploration geochemistry, especially for base metal ore deposits.
AtıfScopus8WoS8OpenAlex10İncele - Editöre MektupAçık Erişim2016Scopus SJRQ2A novel integron gene cassette harboring VIM-38 metallo-β-lactamase in a clinical pseudomonas aeruginosa isolate
Beriş, Fatih Şaban; Akyildiz, Esma; Düzgün, Azer Özad; Coşkun, Umut Safiye Say; Sandalli, Cemal; Çiçek, Ayşegül Çopur
AtıfScopus5WoS5OpenAlex4İncele - MakaleYalnız künye2016Scopus SJRQ2Comparison of local geoid height surfaces, in the province of Trabzon
Karaaslan, Özge; Tanır Kayıkçı, Emine; Aşık, Yusuf
In this study, the estimation of a local geoid model in the area of Trabzon by using geometric methods is presented. The geometric method used in this study interpolates Global Positioning System-derived ellipsoidal and orthometric heights by using the weighted average interpolation, polynomial surface regression, and multiquadratic interpolation. The orthometric and ellipsoidal heights measured at 600 C3 order control stations within a reference benchmark network covering the entire area of Trabzon in Turkey were used in this study. From the existing orthometric and ellipsoidal heights at control stations, the geoid heights were determined. Control stations were divided into two sets, namely, “reference stations” and “testing stations,” to test the estimated geoid height surface. The three methods are compared from a practical point of view by using the descriptive statistics of the root mean square error, mean absolute error, maximum error, and minimum error of the geoid height residuals.
AtıfScopus9WoS9OpenAlex11İncele - MakaleYalnız künye2016Scopus SJRQ2Influences of seasonal alterations on the burning characteristics of impregnated and surface treated chestnut (Castanea sativa mill ) wood
Yasar, S. Sadiye; Fidan, Muhammed Said; Yasar, Mehmet; Atar, Musa; Alkan, Elif
Wood material is generally preferred due to its resilience against earthquakes, aesthetic properties, and its warmth as well as being natural. One of the major problems of employing this natural and breathable product is its ease of combustibility. Despite this adverse characteristic, its high resistance against burning and its ability to maintain its weight bearing characteristics until the very end does not lead to sudden collapses as is seen in steel and concrete systems. Treating wood with impregnating materials in order to improve its resistance against burning is an improved safety measure for the prevention of ignition. This study investigate seasonal effects on the ignition characteristics of chestnut wood samples impregnated using either Tanalith-E or Wolmanit-CB as detailed in ASTM-D 1413-76 and surface-treated using water-based or synthetic varnish as detailed in ASTM-D 3023- 88. The temperature of burning process was the highest in the investigated samples, in those impregnated with Wolmanit-CB and those that were treated with water-based varnish. The results of the study indicated that weight loss was lower during winter (84.59 %), for samples that were impregnated using Wolmanit-CB (84.46 %) and in those that were treated with water-based varnish (84.18 %). On the other hand, the O2 content was determined to be the highest and the CO content the lowest in winter samples that were impregnated using Wolmanit-CB and treated with synthetic varnish.
AtıfScopus5WoS5İncele - MakaleAçık Erişim2016Scopus SJRQ2Stability assessment of high-steep cut slope debris on a landslide (Gumushane, NE Turkey)
Kaya, Ayberk; Alemdağ, Selçuk; Dağ, Serhat; Gürocak, Zülfü
The objective of this study was to examine the effects on the stability of slope debris of planned slope excavations around the vicinity of Gumushane Imam-Hatip High School in NE Turkey. To assess the geotechnical properties of slope debris along the determined cross-sections, four exploration boreholes with a total length of 100 m were drilled and undisturbed soil samples were collected. Slope debris is composed of two soil zones and its depth varies between 15 m and 21 m. It was determined from the experimental results that the soil class of the upper zone is CL (low plasticity clay) and CH (high plasticity clay) whereas the soil class of the lower zone is SC (clayey sand) and GC (clayey gravel). Peak cohesions of the upper and lower zones were 26.3 kPa and 10.2 kPa, and their peak internal friction angles were 16° and 24°, respectively. Limit equilibrium (LE) analyses for the slopes were evaluated using Slide v5.0 software for the pre-excavation, post-excavation, and supported cases. The results of LE analyses showed the existence of a landslide along the SW direction; the landslide would extend to cover the whole region if the excavation were to be performed without applying engineering measures. Finally, the precautions to be taken were determined and stability analyses for the supported case were evaluated. These analyses showed that the active lateral forces applied by the proposed retaining walls to the cut slope should be 8325 and 3103 kN, respectively.
AtıfScopus35WoS28OpenAlex41İncele - MakaleYalnız künye2016Scopus SJRQ2A New Approach for Determination of Volumetric Water Content in Soil Samples by Gamma-Ray Transmission
Celik, Necati; Altin, Duygu; Cevik, Ugur
A new method was presented for the purpose of volumetric water content determination in any soil sample by gamma-ray transmission. Monte Carlo (MC) simulation technique was used to determine the functional behavior of the linear attenuation coefficient of soil samples having different water contents for three soil samples. Using this functional behavior, the linear attenuation coefficients of dry soil and water were obtained from the intercept and the slope, respectively. It was experimentally shown that the mass attenuation coefficients of soil samples were not sensitive to the chemical composition but only to the physical density. This independence was exploited in this study to obtain the linear attenuation coefficient of a completely dry soil which was found to be 0.1409, 0.1274, and 0.1657 cm−1 for Gumushane, Ardahan, and Trabzon soil, respectively. The linear attenuation coefficient of water was determined to be 0.09 cm−1. Then, the volumetric water contents were obtained by measuring the gamma-ray intensities passed through three wet soil samples. The results were found to be 0.186, 0.182, and 0.214 cm3 cm−3 for Gumushane, Ardahan, and Trabzon soil, respectively. The results obtained by the method introduced were compared with the results obtained using gravimetric method. A very good agreement was observed.
AtıfScopus7WoS7OpenAlex8İncele - MakaleYalnız künye2016Scopus SJRQ2Effects of organic solid cattle manure application on nutritive value of winter cereal forages
Yolcu, H.; Gullap, M.K.; Yildirim, M.; Lithourgidis, A.; Deveci, M.
Nutritive value of winter cereal forages is one of interested subjects of farmers for animal feeding. Field experiments were established in 2007–2008 and 2008–2009 growing seasons in northeast Turkey to investigate the effect of organic solid cattle manure application (0, 10 and 20 Mg ha−1 yr−1) on nutritive value of three annual cereals for forage. The winter cereal forages were: wheat (Triticum aestivum L.), oat (Avena sativa L.) and rye (Secela cereale L.). ADF (acid detergent fiber), NDF (neutral detergent fiber) CP (crude protein), nitrogen, phosphorus, potassium, sulfur, calcium, copper, iron, magnesium, manganese, sodium, zinc and boron (N, P, K, S, Ca, Cu, Fe, Mg, Mn, Na, Zn and B) concentrations were researched in this study. Wheat had the highest CP, N, Ca, Cu, Na and Zn concentration, whereas oat had the lowest ADF and NDF and the highest K, Fe and Mn concentrations. The greatest Mg and P concentrations were determined in rye. Organic solid cattle manure applications had no effect on N and CP contents, but it decreased ADF and NDF contents. However, in most cases it positively affected the P, B, Cu, Fe, Mg and Na concentrations, whereas it decreased K, Ca, Mn and Zn concentrations. The results showed that wheat and oat are more nutritive species than rye in terms of animal feeding and the organic solid cattle manure, in some cases increased the nutritive values of wheat, oat and rye under organic agriculture conditions.
AtıfScopus4WoS6OpenAlex6İncele - MakaleYayıncıda açık erişim2016Scopus SJRQ1Effects of non-uniform temperature distribution on critical member temperature of steel tubular truss
Ozyurt, E.; Wang, Y.C.
This paper examines the effects of thermal restraint, caused by non-uniform temperature distribution in different members, on the failure temperatures of critical members of steel tubular trusses. Non-uniform temperature distribution develops in trusses exposed to localised fire attack. The truss member nearest to the fire source experiences the highest temperature, with reduced temperatures in the nearby members. The number of the nearby truss members being heated and their temperatures will affect the failure temperature of the critical truss member which has the highest temperature. The aim of this paper is to develop a simplified method to account for the effects of different numbers of members being simultaneously heated to different temperatures on the development of compression force and failure temperature of the critical member. Finite Element (FE) simulations were carried out for Circular Hollow Section (CHS) trusses using the commercial Finite Element software ABAQUS v6.10-1 which has previously been validated by the authors. The simulation trusses were subjected to constant mechanical loads and then increasing temperatures until failure. The elevated temperature stress-strain curves were based on EN-1993-1-2 [1]. Initial geometrical imperfections were included, based on the lowest buckling mode from eigenvalue analysis.The numerical study examined the effects of truss type, critical member slenderness, applied load ratio and axial restraint stiffness ratio on the failure temperatures of the critical truss members. The numerical simulation results were used to check the accuracy of a proposed simplified calculation method, combining linear elastic static truss analysis at ambient temperature and analytical equations to calculated the failure temperatures of thermally restrained truss members based on the regression equations of Wang et al. [2]. The calculation method was shown to be sufficiently accurate for fire resistant design purpose.
AtıfScopus27WoS24OpenAlex26İncele - MakaleAçık Erişim2016Scopus SJRQ3Increased expressions of eNOS and iNOS correlate with apoptosis of diabetic nephropathy in streptozotocin-induced type 1 diabetic rats; [Streptozotosin kaynaklı tip 1 diyabetik sıçanlarda meydana gelen nefropatilerde artan eNOS ve iNOS sunumlarının apoptozisle ilişkilendirilmesi]
Dinçel, Güngör Çağdaş; Yildirim, Serkan
The present study was designed to evaluate the effects of high level of nitric oxide (NO) production and oxidative stress (OS) on nephropathology and to identify whether NO and OS have any correlation with apoptosis seen in diabetic kidney, elucidating the underlying mechanism(s) involved in the development of nephropathology in streptozotocin (STZ)-induced diabetic rats. Expression levels of caspase 3, caspase 9, endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), 8-hydroxy-2′-deoxyguanosine (8-OHdG), for the detection of oxidative damage to DNA, were examined in diabetic kidney tissues. Results of the study revealed that the levels of 8-OHdG (P<0.005), eNOS (P<0.005), iNOS (P<0.005), caspase 3 (P<0.005) and caspase 9 (P<0.005) were remarkably higher in diabetic kidney tissues than in controls. In addition, STZ-treated animals showed significant loss of body weight and renal enlargement. It was suggested that apoptosis, OS and increased NO levels are involved in the pathogenesis of diabetic nephropathy. The results also strongly suggested that STZ-induced apoptosis through activation of the intrinsic pathway and that might be most likely related to increased NO levels. Moreover, high NO production was not only mediated by eNOS but also by iNOS. Increased NO production may contribute to hyperfiltration and microalbuminuria in early diabetic nephropathy. Furthermore, expression of 8-OHdG might give an idea of the progress and may be essential as it has a diagnostic significance for this disease. In conclusion, we believe that eNOS and iNOS overexpressions induce diabetic nephropathy by mediating apoptosis in STZ-induced rats.
AtıfScopus4WoS4İncele - MakaleYalnız künye2016Scopus SJRQ4A semiautomatic segmentation approach to biometric measurement of the talus bone of sedentary women and ballerinas using CT images
Reis, Hatice Catal; Bayram, Bulent; Seker, Dursun Zafer
Background: Ballet produces much stress on bones in the feet of ballerinas. Monitoring and detecting talus bone deformation is important for their quality of health and profession. Objectives: To determine differences in the talus bone between ballerinas and sedentary women. Methods: We evaluated biometric differences in the talus bone of 5 ballerinas referenced to 5 similar sedentary women recruited into the present study. We acquired 20 multidetector computed tomographic images including right and left feet. Semiautomatic region-based image processing using 3D-Doctor (Able Software Corp) was used to create three-dimensional (3D) virtual models of the talus bones. Biometric measurements were made on the 3D models and statistical analysis conducted. Results: The mean talus bone length of ballerinas was 3.37 cm (SD 0.12; range 3.11 to 3.52). The talus bone length of sedentary women was 3.29 cm (SD 0.16; range 3.04 to 3.65), and tended to be shorter than that of the ballerinas (P = 0.08, t test). However, the test was insufficiently powered. The mean volume of the talus bones from the ballerinas was 24.8 cm3 (SD 0.83) and smaller than that from the sedentary women, 26.9 cm3 (SD 1.25) at P < 0.001 (t = 4.38, 18 degrees of freedom. Difference 2.1. Two-tailed 95% confidence interval for difference of means: 1.08 to 3.08). We found less variation in the feet of ballerinas than sedentary women. Conclusions: Volumetric measurements show that feet of ballerinas are smaller and retain similar shape and size than the irregular feet of sedentary women.
AtıfScopus3OpenAlex1İncele - MakaleAçık Erişim2016Scopus SJRQ4Effects of Origanum syriacum essential oil added in different levels to the diet of broilers under heat stress on performance and intestinal histology; [Einfluss des zusatzes der essentiellen Öle von origanum syriacum in unterschiedlicher höhe zum futter auf die leistung und die darmmorphologie von broilern unter hitzestress]
Tekce, E.; Gül, M.
This study compared the effects on performance parameters, intestinal microflora and histology of adding Origanum syriacum (OS) essential oil and an antibiotic (Avilamycin) to the rations of broilers fed under heat stress conditions. The 42-day study used 500 day-old male broilers (Ross-308) divided into 10 groups of 50 animals each. Then, each of these groups was further divided into 5 groups of 10 each. Groups were either kept at 22°C (stress-free) or at 36°C (heat stressed). Birds were fed with 5 experimental diets: control (basic feed (BF) without feed additive), antibiotic (BF + 100 mg/kg Avilamycin), OS 100 (BF + 100 mg/kg OS), OS 300 (BF + 300 mg/kg OS, OS 600 (BF + 600 mg/kg OS). At the end of the study period, some performance parameters, including feed intake, feed-conversion ratio, body weight, average daily weight gain, ileum crypt depth, villus height and microflora, decreased in groups under heat stress without additives (P < 0.01). However, comparison with the control group and the antibiotic group showed that adding OS essential oil provided a benefit close to that of the antibiotic, yet still inadequate, even at the 600 mg/kg dose.
AtıfScopus17WoS15OpenAlex12İncele - MakaleAçık Erişim2016Scopus SJRQ3Physicochemical and bioactive properties of cakes incorporated with gilaburu fruit (Viburnum opulus) pomace
Şeker, I.T.; Ertop, M.H.; Hayta, M.
In this study the valorisation of a gilaburu (Viburnum opulus) fruit pomace, a waste product remaining after juice extraction, was investigated. The pomace was incorporated into cake formulation at the level of 0, 5, 10 and 15%, based on wheat flour weight. Results indicated that the batter viscosity increased and pH decreased by the increasing of the concentration of pomace level in cake formulation. Depending on incorporation level, reduction on the volume and height of the cake samples were observed. The hardness values increased whereas the chewiness and gumminess values of the cake samples decreased with an increasing of pomace incorporation level. Gilaburu pomace addition caused significant (P<0.05) changes on L*, a*, and b* values of crumb, whereas no significant differences have been determined on the L* and b* values of crust of the samples. In sensory analyses, 5% gilaburu pomace added cake sample had the highest overall acceptability score. The total phenolic content and radical-scavenging activity values of cake samples increased proportionally with the level of pomace incorporation. According to the study, evaluation of gilaburu pomace waste as ingredient in developing alternative functional and/or value-added products by the food industry could be suggested.
AtıfScopus13WoS12OpenAlex16İncele - MakaleYalnız künye2016Scopus SJRQ3Selective cytotoxic effect of Rhododendron luteum extract on human colon and liver cancer cells
Demir, Selim; Turan, Ibrahim; Aliyazicioglu, Yuksel
Purpose: The genus Rhododendron is distributed entirely in the world with the exception of South and Central America and Africa, growing in a large diversity of climatic conditions. This genus is a rich source of phenolic compounds, especially flavonoids, essential oils, chromones, terpenoids, and steroids. It has many biological properties such as antioxidant, anti-inflammatory, antiviral, antibacterial, anticancer, antidiabetic, immunomodulatory, cardioprotective and hepatoprotective among others due to their polyphenolic constituents. The objective of the current study was to evaluate the antioxidant properties and cytotoxic activity of dimethyl sulfoxide extract of flowers of Rhododendron luteum (DEFR) for the first time. Methods: The total polyphenolic contents (TPC), total flavonoid contents (TFC) and ferric reducing antioxidant power (FRAP) of the extract were evaluated using spectrophotometry procedures. The cytotoxic activity of the extract on three cancers (human breast, colon and liver carcinoma) and human foreskin fibroblast cells was determined using the MTT assay. Results: TPC and FRAP values were found 54.2+.0.38 mg gallic acid equivalents and 164.2±1.77 mg trolox equivalents per to g sample, respectively. R. luteum extract exhibited selective cytotoxicity against colon and liver cancer cells compared to normal fibroblast cells, while this selective cytotoxicity was not observed in breast cancer cells. Conclusion: Our results demonstrate that the Rhododendron luteum may be a great source of antioxidant and antitumor natural agents due to their capability of decreasing cancer cells proliferation.
AtıfScopus25WoS29İncele - MakaleAçık Erişim2016Scopus SJRQ3Role of oxidative stress in the pathophysiology of Toxoplasma gondii infection
Dincel, Gungor Cagdas; Atmaca, Hasan Tarik
Oxidative stress (OS) plays an essential role in the pathogenesis of common neurodegenerative diseases. We have previously shown that Toxoplasma gondii (T. gondii) induces high nitric oxide (NO) production, glial activation, and apoptosis that altogether cause severe neuropathology in toxoplasma encephalitis (TE). The objective of this study was to investigate the cytotoxic effect of OS and to identify a correlation between the causes of T. gondii induced neuropathology. Expression levels of glutathione reductase (GR), Cu/Zn superoxide dismutase (SOD1), neuron specific enolase (NSE), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated. Results of the study revealed that the levels of GR (P <0.005) and NSE (P <0.001) expression in the brain tissue markedly increased while SOD1 activity decreased (P <0.001) in the infected group compared to the non-infected group. In addition, intense staining for 8-OHdG (P <0.05) was observed both in the nucleus and the cytoplasm of neurons and glial cells that underwent OS. These results were reasonable to suggest that T. gondii-mediated OS might play a pivotal role and a different type of role in the mechanism of neurodegeneration/neuropathology in the process of TE. The results also clearly indicated that increased levels of NO and apoptosis might contribute to OS-related pathogenesis of TE. As a result, OS and expression of NSE might give an idea of the disease progress and may have a critical diagnostic significance for patients with T. gondii infection.
AtıfScopus64WoS55OpenAlex62İncele