Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(62)
- Merdan, Mehmet(58)
- Duran, Celal(50)
- Ozdes, Duygu(47)
- Kaygusuz, Abdullah(43)
- Ashyralyyev, Charyyar(38)
- Karsli, Orhan(33)
- Öztürk, Serkan(32)
- Araz, Onur(31)
- Demir, Selim(29)
- Kulakaç, Nurşen(29)
- Dokuz, Abdurrahman(28)
- Arslan, Mehmet(27)
- Baltacı, Cemalettin(27)
- Maden, Nafiz(27)
- Sipahi, Ferkan(27)
- Topal, Fevzi(27)
- Turan, Ibrahim(27)
- Kandemir, Raif(25)
- Kurt, Kemal(24)
- Ozturk, Samet(24)
- Peker, Iskender(24)
- Vural, Alaaddin(24)
- Reis, Hatice Catal(23)
- Yücel, Cem(23)
- Aydin, Faruk(22)
- Baltaci, Cemalettin(22)
- Gücer, Mehmet Ali(22)
- Günen, Mehmet Akif(22)
- Kankal, Murat(22)
- Topal, Meryem(22)
- Karimullah, Suud Sarim(21)
- Uysal, Ibrahim(20)
- Kurnaz, Muammer(19)
- Tuncer, Metin(19)
- Yolcu, Halil(19)
- Çelik, Necati(19)
- Ürkek, Bayram(19)
- Şan, Murat(19)
- Aliyazicioglu, Yuksel(18)
Yayınlar
- MakaleAçık Erişim2021Scopus SJRQ2Solutions of multiplicative ordinary differential equations via the multiplicative differential transform method
Yalçın, Numan; Dedeturk, Mutlu
In this study, fundamental definitions and theorems of the Multiplicative Differential Transform Method (MDTM) are given. First and second order multiplicative initial value problems are numerically solved with the help of MDTM.
AtıfScopus15WoS15OpenAlex21
İncele - MakaleYalnız künye2021Scopus SJRQ1Analysis of relationships between nanotechnology applications, mineral saving and ecological footprint: Evidence from panel fourier cointegration and causality tests
Koç, Pınar; Gülmez, Ahmet
Analyzing the relationship between nanotechnology applications, mineral saving, and environmental degradation is important to achieve sustainable development goals. However, in the literature, no study empirically examines the interaction among nanotechnology applications, mineral saving, and environmental degradation. This study addresses this significant gap in the literature by investigating the impacts of nanotechnology applications on mineral saving and the ecological footprint in 9 countries (Australia, Canada, China, France, Japan, Korea, Russia, Sweden, and the USA) in the period 1990–2017 using the combined panel fourier fractional cointegration and panel fractional fourier causality test. According to the causality test results based on group statistics, there is a Granger causality from nanotechnology applications to mineral saving. Also, there is causality from mineral saving to ecological footprint. The estimations of the causality based on individual statistics show no causality linkage between nanotechnology applications and mineral saving in the countries, excluding Australia and France. Canada, China, France, and Sweden are countries with unilateral causality from nanotechnology applications to ecological footprint. In the other countries, except China, Japan, and the USA, mineral saving doesn't Granger cause ecological footprint. The long-run findings show a positive impact of nanotechnology applications on mineral saving and ecological footprint. These findings are valid for all countries. In this context, it can be concluded that nanotechnology applications are essential for resource-saving. But, to save resources, the authorities should focus on controlling and measuring nanoparticle emissions.
AtıfScopus10WoS8OpenAlex11İncele - Kitap BölümüYalnız künye2021The effect of covid-19 pandemic on solidarity culture in Turkey
Kose, Asli
COVID-19 outbreak has become important problem of the World in 2020. World Health Organization accepted COVID-19 outbreak a pandemic on March 11, 2020. With the pandemic workplaces closed and production decreased. COVID-19 pandemic is affecting Turkey socially and economically as it is affecting many countries in global health. In Turkey, it is determined the first corona virus cases in March 2020. It may have some negative economicial, educational, agricultural and public health effects. This study includes a content that evaluates the adversities of the COVID-19 pandemic affecting social assistance. Social assistances are usually planned by central governments and implemented by local governments. Municipalities, one of the local governments, are one of the important institutions in delivering social assistances to the puclic. Central goverment and local goverments tried to support the public with social benefits by using different resources in COVID-19 pandemic. In this process, the culture of solidarity came to the fore. Turkey is experiencing the most beautiful examples of solidarity culture of the country in location. The world has also contributed positively to its image in addition to creating social benefits with the helth aids provided. The need for social assitances is excepted to increase in the face the consequences of the crisis in the future period. This situation will increase the need of public institutions for governance.
- MakaleAçık Erişim2021Scopus SJRQ2The relationship between anxiety levels and anger expression styles of nurses during COVID-19 pandemic
Bayrak, Nurten Gülsüm; Uzun, Sevda; Kulakaç, Nurşen
Objective: This study was carried out in a cross-sectional and correlational design to explore the relationship between anxiety levels and anger expression styles of nurses during the COVID-19 pandemic. Methods: The sample of this cross-sectional and correlational type of study consisted of 618 nurses calculated with the snowball sampling method. The data were collected using a questionnaire developed by the researchers, the state anxiety inventory, and the trait anger and anger expression scale and was conducted between May 10 and 20, 2020 using an online questionnaire form. Percentage, mean, standard deviation, the Mann–Whitney U test, Kruskal–Wallis test, Spearman correlation analysis, and multiple linear regression analysis were used to evaluate the data. Results: The mean age of nurses was 34.98 ± 8.36 years (min: 20; max: 53), 87.4% were women, and 81.7% experienced a high level of anxiety. The anger scores of the participants were found to be 20.04 ± 4.43, the anger-in score was 15.55 ± 3.34, the anger-out score was 14.01 ± 2.87, and the anger control score was 22.93 ± 3.6. Being married, the presence of chronic disease, living in the Marmara region, working shifts, presence of an individual over 65 years of age at home, and having a COVID-19 test were found to be risk factors that significantly increase nurses' anxieties. A significant positive relationship was found between the anxiety scores, trait anger (r = 0.249, p = 0.000), anger-in (r = 0.174, p = 0.000) and anger-out (r = 0.205, p = 0.000) scores of nurses, and a significant negative relationship was found between the anxiety scores and anger control (r = 0.249, p = 0.000) score. Conclusion: The study revealed that in the COVID-19 pandemic the anxiety levels of the nurses were high and that the high anxiety level negatively affected the style of anger expression, but the nurses were successful in maintaining anger control. In line with these results, it is important that nurses develop effective coping strategies to reduce their anxiety levels and that they receive increased levels of support in managing anger expression.
AtıfScopus14WoS12OpenAlex20
İncele - MakaleYalnız künye2021Scopus SJRQ1Static resistance of axially loaded multiplanar gap KK-joints of Circular Hollow sections at elevated temperatures
Wang, Y.C.; Ozyurt, E.
This paper presents the results of a numerical investigation of the behaviour, and proposes a method to calculate the static resistance of axially loaded Circular Hollow Section Double K-joints (DKK) at elevated temperatures. This type of joints is widely used in building construction, but currently, there is no method to calculate their static resistance at elevated temperatures. The numerical investigations of this paper cover a wide range of design parameters, including brace axial load combination, joint temperature, angles between brace members, longitudinal and transverse gap sizes, chord diameter to thickness ratio and brace diameter to chord diameter ratio. The results of this paper indicate that the ratio of joint elevated temperature resistance to ambient temperature resistance may be lower than the reduction factor for the yield strength of steel at elevated temperatures. There are two joint failure modes, one for small and one for large transverse gap. These failure modes and the demarcation between small and large gaps are independent of joint temperature. For joints with large gap, the ratio of joint resistance at elevated temperature to that at ambient temperature is close to the average of steel yield strength and Young's modulus reduction factors at elevated temperature. For joints with small gap, the joint resistance ratio follows the steel Young's modulus factor variation at elevated temperature if all four braces are under compression, but the trend changes to the average ratio of steel Young's modulus and yield strength reduction factors if the axial brace loads are balanced (compression in two brace members equal to tension force in the other two brace members). Linear interpolation can be applied between these two different loading cases.
AtıfScopus17WoS15OpenAlex17İncele - Derleme MakaleYalnız künye2021Scopus SJRQ1Assessment of the relationship between renewable energy and employment of the United States of America: Empirical evidence from spectral Granger causality
Çelik, Orkun
In this study, the spectral Granger causality nexus between renewable energy generation and employment for the period February 1973–September 2019 in the USA is examined. The results obtained from the study expresses that there is no spectral Granger causality relationship between renewable energy generation and employment for aforementioned period in the USA. Furthermore, these findings support neutrality hypothesis, which means that there is no causality relation between the variables. In other words, renewable energy generation does not influence employment and employment does not have an effect on renewable energy generation.
AtıfScopus16WoS14OpenAlex20İncele - MakaleAçık Erişim2021Scopus SJRQ3Experimental and numerical studies on predicting and improving the full-scale wastewater treatment plant hydrodynamics
Şibil, Rahim; Aras, Egemen; Kankal, Murat
This paper presents the results of both experimental and numerical studies on biological wastewater treatment plant (WWTP), oxidation ditches (OD) hydrodynamics to design and develop the desired flow conditions of the WWTP. Computational fluid dynamics (CFD) models were developed using CFD software, ANSYS Fluent (V13) with the three-dimensional, steady, incompressible flow based on the Reynolds-Averaged Navier-Stokes equations for flow field calculations in the combined ODs. Also, three different turbulence models [standard k–ε (ske), renormalization group k–ε (RNG), and realizable k–ε (real)] were performed for a comparative study. The numerical model was verified based on the experimental data in the relative errors for ske, RNG, and real 13%, 17%, and 18%, respec-tively. According to the parametric studies, the hydrodynamic characteristics of the existing WWTP were investigated. The maximum wastewater velocity occurred at the inlet and outlet, affecting the flow field in ODs. Moreover, the water velocity decreased as it moved away from the inlet and outlet locations at vertical and horizontal. It can also be noted that there was no homogeneous flow field distribution in ODs. Because the current OD model needs improvement hydrodynamically, a new original OD geometry was presented to eliminate the hydraulic weakness of existing WWTP by CFD analysis. The new original geometry provides a more homogeneous flow field in ODs that mean it will also help treatment efficiency and energy saving according to the operating principles of this facility.
AtıfScopus8WoS8OpenAlex8İncele - MakaleAçık Erişim2021Solving Bigeometric Volterra Integral Equations by Using Successive Approximations Method
Güngör, Nihan
In this study, the successive approximations method has been applied to investigate the solution for the linear bigeometric Volterra integral equations of the second kind in the sense of bigeometric calculus. The conditions to be taken into consideration for the bigeometric continuity and the uniqueness of the solution of linear bigeometric Volterra integral equations of the second kind are researched. Finally, some numerical examples are presented to illustrate successive approximations method.
AtıfScopus1OpenAlex1TR Dizin1
İncele - MakaleYalnız künye2021Scopus SJRQ3The solutions of multiplicative Hermite differential equation and multiplicative Hermite polynomials
Yalçın, Numan
In this work, we give the power series solutions around an ordinary point, in the case of variable coefficients, homogeneous multiplicative differential equations of 2nd order. Further, we introduce the multiplicative Hermite differential equations, multiplicative Hermite polynomials and basic properties of these polynomials.
AtıfScopus17WoS18OpenAlex23İncele - Derleme MakaleAçık Erişim2021Scopus SJRQ1The Large Hadron-Electron Collider at the HL-LHC
Agostini, P.; Aksakal, H.; Alekhin, S.; Allport, P. P.; Andari, N.; Andre, K. D. J.; Angal-Kalinin, D.; Antusch, S.; Aperio Bella, L.; Apolinario, L.
The Large Hadron-Electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy-recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High-Luminosity Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron-proton and proton-proton operations. This report represents an update to the LHeC's conceptual design report (CDR), published in 2012. It comprises new results on the parton structure of the proton and heavier nuclei, QCD dynamics, and electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics by extending the accessible kinematic range of lepton-nucleus scattering by several orders of magnitude. Due to its enhanced luminosity and large energy and the cleanliness of the final hadronic states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, this report contains a detailed updated design for the energy-recovery electron linac (ERL), including a new lattice, magnet and superconducting radio-frequency technology, and further components. Challenges of energy recovery are described, and the lower-energy, high-current, three-turn ERL facility, PERLE at Orsay, is presented, which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution, and calibration goals that arise from the Higgs and parton-density-function physics programmes. This paper also presents novel results for the Future Circular Collider in electron-hadron (FCC-eh) mode, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies.
AtıfScopus272WoS219OpenAlex253İncele - MakaleAçık Erişim2021Scopus SJRQ1LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kinkor (Ferulago stellata)
Kiziltas, Hatice; Bingol, Zeynebe; Gören, Ahmet Ceyhan; Kose, Leyla Polat; Durmaz, Lokman; Topal, Fevzi; Alwasel, Saleh H.; Gulcin, Ilhami
Kinkor (Ferulago stellata) is Turkish medicinal plant species and used in folk medicine against some diseases. As far as we know, the data are not available on the biological activities and chemical composition of this medicinal plant. In this study, the phytochemical composition; some metabolic enzyme inhibition; and antidiabetic, anticholinergic, and antioxidant activities of this plant were assessed. In order to evaluate the antioxidant activity of evaporated ethanolic extract (EEFS) and lyophilized water extract (WEFS) of kinkor (Ferulago stellata), some putative antioxidant methods such as DPPHGreek ano teleia scavenging activity, ABTS(center dot+) scavenging activity, ferric ions (Fe3+) reduction method, cupric ions (Cu2+) reducing capacity, and ferrous ions (Fe2+)-binding activities were separately performed. Furthermore, ascorbic acid, BHT, and alpha-tocopherol were used as the standard compounds. Additionally, the main phenolic compounds that are responsible for antioxidant abilities of ethanol and water extracts of kinkor (Ferulago stellata) were determined by liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Ethanol and water extracts of kinkor (Ferulago stellata) demonstrated effective antioxidant abilities when compared to standards. Moreover, ethanol extract of kinkor (Ferulago stellata) demonstrated IC50 values of 1.772 mu g/mL against acetylcholinesterase (AChE), 33.56 +/- 2.96 mu g/mL against alpha-glycosidase, and 0.639 mu g/mL against alpha-amylase enzyme respectively.
AtıfScopus66WoS62OpenAlex64İncele - MakaleAçık Erişim2021Scopus SJRQ1Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.) - profiling of phenolic compounds by LC-HRMS
Bingol, Zeynebe; Kiziltas, Hatice; Gören, Ahmet C.; Kose, Leyla Polat; Topal, Meryem; Durmaz, Lokman; Alwasel, Saleh H.; Gulcin, Ilhami
In order to evaluate the antioxidant activity of evaporated ethanolic extract (EESB) and lyophilized water extract (WESB) of Shaggy bindweed (Convulvulus betonicifolia Mill. Subs), some putative antioxidant methods such as DPPH. scavenging activity, ABTS(center dot)(-) scavenging effect, ferric ions (Fe3+) reduction method, cupric ions (Cu2+) reducing capacity, and ferrous ions (Fe2+) binding activities were separately performed. Also, ascorbic acid, alpha-tocopherol and BHT were used as the standard compounds. Additionally, some phenolic compounds that responsible for antioxidant abilities of EESB and WESB were screened by liquid chromatography-high resolution mass spectrometry (LC-HRMS). At the same concentration, EESB and WESB demonstrated effective antioxidant abilities when compared to standards. In addition, EESB demonstrated IC50 values of 1.946 mu g/mL against acetylcholinesterase (AChE), 0.815 mu g/mL against alpha-glycosidase and 0.675 mu g/mL against alpha-amylase enzymes.
AtıfScopus84WoS83OpenAlex88İncele - MakaleYalnız künye2021Scopus SJRQ3The effect of chewing gum on dry mouth, interdialytic weight gain, and intradialytic symptoms: A prospective, randomized controlled trial
Ozen, Nurten; Aydin Sayilan, Aylin; Mut, Dilek; Sayilan, Samet; Avcioglu, Zeynep; Kulakac, Nursen; Ecder, Tevfik; Akyolcu, Neriman
Introduction The major salivary glands can be stimulated by chewing gum to increase saliva flow and decrease xerostomia. The aim of this study was to investigate the effect of chewing gum on dry mouth, interdialytic weight gain, and intradialytic symptoms in hemodialysis (HD) patients. Methods This prospective randomized controlled single-blind study was conducted with patients who had been treated for at least 6 months with sessions 3 days a week for 4 hours at two HD units. Patients were randomly allocated to chewing gum group or the control group. In the chewing gum group, gum was chewed for 10 minutes six times a day, and when the patients felt mouth dryness or were thirsty. In the nonchewing gum group, gum was not chewed. The patients were followed-up for 3 months. A total of three saliva samples were taken before starting treatment at the first, 12th, and 36th HD session. Data were collected with the Visual Analogue Scale (VAS), Hemodialysis Patients Fluid Control Scale, Dialysis Symptom Index, and Hospital Anxiety and Depression Scale at baseline, week 4, week 8, and week 12. Findings The study was completed with a total of 44 patients consisting of 22 patients in the each group. The second and third month VAS values (xerostomia) of the patients in the chewing gum groups were statistically significantly lower than those in the control group (P= 0.014,P < 0.001, respectively). The third month salivary flow rate in the chewing gum group was higher than the values in the control group patients (P < 0.001). Discussion It is anticipated that this study will raise nurses' awareness of dry mouth and encourage future studies on interventions to increase the salivary flow rate to prevent or treat dry mouth.
AtıfScopus18WoS19OpenAlex27İncele - MakaleAçık Erişim2021Scopus SJRQ1Non-Invasive Monitoring of Ethanol and Methanol Levels in Grape-Derived Pisco Distillate by Vibrational Spectroscopy
Menevseoglu, Ahmed; Aykas, Didem P.; Hatta-Sakoda, Beatriz; Toledo-Herrera, Victor Hugo; Rodriguez-Saona, Luis E.
Handheld Raman and portable FT-IR spectroscopy devices were evaluated for fast and non-invasive determination of methanol and ethanol levels in Peruvian Pisco. Commercial Peruvian Pisco (n = 171) samples were kindly provided by the UNALM Alliance for Research in Alcohol and its Derivatives (Lima, Peru) and supplemented by purchases at grocery and online stores. Pisco spectra were collected on handheld Raman spectrometers equipped with either a 1064 nm or a 785 nm excitation laser and a portable infrared unit operating in transmission mode. The alcohol levels were determined by GC-MS. Calibration models used partial least-squares regression (PLSR) to develop prediction algorithms. GC-MS data revealed that 10% of Pisco samples had ethanol levels lower than 38%, indicating possible water dilution. Methanol levels ranged from 10 to 130 mg/100 mL, well below the maximum levels allowed for fruit brandies. Handheld Raman equipped with a 1064 nm excitation laser gave the best results for determining ethanol (SEP = 1.2%; RPre = 0.95) and methanol (SEP = 1.8 mg/100 mL; RPre = 0.93). Randomly selected Pisco samples were spiked with methanol (75 to 2800 mg/100 mL), and their Raman spectra were collected through their genuine commercial bottles. The prediction models gave an excellent performance (SEP = 98 mg/100 mL; RPre = 0.97), allowing for the non-destructive and non-contact determination of methanol and ethanol concentrations without opening the bottles.
AtıfScopus19WoS17OpenAlex21İncele - MakaleYalnız künye2021Scopus SJRQ2Non-targeted approach to detect green pea and peanut adulteration in pistachio by using portable FT-IR, and UV-Vis spectroscopy
Menevseoglu, Ahmed; Aykas, Didem Peren; Adal, Eda
Pistachio is one of the most expensive nuts with having high economic importance in Turkey. It has become more prone to adulteration because of its high commodity value. Peanut with color additives and green pea are generally used to adulterate ground pistachio. Vibrational spectroscopy is a potential technique to detect adulterations in pistachio. The objective of this study was to generate a non-targeted method for portable FT-IR and UV-Vis spectrometers to authenticate pistachio and detect green pea and peanut adulterations. Pistachio granules were adulterated with green pea and peanut at different concentrations (5 to 40% w/w). Spectra were collected by a portable FT-IR spectrometer and by a conventional UV-Vis spectrometer and analyzed by Soft Independent Modeling of Class Analogy (SIMCA) to generate classification algorithms to authenticate pistachio, and Partial Least Square Regression (PLSR) to predict the concentrations of adulterants. SIMCA showed very distinct clusters for pure samples. Moreover, adulterated pistachio samples were discriminated by SIMCA even in low levels of adulteration (5%). Portable FTIR showed excellent performance (r(val) > 0.93) of predicting the adulterant levels with a standard error of prediction (SEP) 0.66% and 0.80% for green pea and peanut, respectively. Similarly, UV-VIS predicted (r(val) > 0.93) the adulterant levels with SEP 0.58% and 0.14% for green pea and peanut, respectively. The results supported that portable FT-IR, and UV-Vis units present great potential for real-time surveillance of green pea and peanut adulteration in pistachio.
AtıfScopus13WoS12OpenAlex15İncele - MakaleAçık Erişim2021Scopus SJRQ2Role of the Health System in Combating Covid-19: Cross-Section Analysis and Artificial Neural Network Simulation for 124 Country Cases
Bayraktar, Yuksel; Özyilmaz, Ayfer; Toprak, Metin; Isik, Esme; Büyükakin, Figen; Olgun, Mehmet Firat
In the fight against Covid-19, developed countries and developing countries diverge in success. This drew attention to the discussion of how different health systems and different levels of health spending are effective in combating Covid-19. In this study, the role of the health system in the fight against Covid-19 is discussed. In this context, the number of hospital beds, the number of doctors, life expectancy at 60, universal health service and the share of health expenditures in GDP were used as health indicators. In the study, firstly 2020 data was estimated by using the Artificial Neural Networks simulation method and this year was used in the analysis. The model, with the data of 124 countries, was estimated using the cross-sectional OLS regression method. The estimation results show that the number of hospital beds, number of doctors and life expectancy at the age of 60 have statistically significant and positive effects on the ratio of Covid-19 recovered/cases. Universal health service and share of health expenditures in GDP are not significant statistically on the cases and recovered. Hospital bed capacity is the most effective variable on the recovered/case ratio.
AtıfScopus17WoS17OpenAlex20İncele - MakaleAçık Erişim2021Scopus SJRQ2Adipokine, gut and thyroid hormone responses to probiotic application in chukar partridges (Alectoris chukar) exposed to heat stress
Bayraktar, Bulent; Tekce, Emre; Kaya, Hacer; Gürbüz, Ahmet Burak; Dirican, Ebubekir; Korkmaz, Serol; Atalay, Banu; Ülker, Ufuk
The aim of this study was to investigate the effect of Lactobacillus reuteri E81 (LRE) probiotic supplementation on heat stress responses in chukar partridges (Alectoris chukar). The birds were divided into two groups, one of which was exposed to heat stress (HS). Within each group, four subgroups, each including 64 birds, were created for the three treatment doses (200, 400 or 600 mg/kg) of LRE and the control. The experiment was started with day-old birds, kept at a temperature of 25 degrees C or 37 degrees C. After a 7-day adjustment period, the LRE supplementation lasted for 35 days. The levels of different adipokines, including visfatin (VF), adiponectin (ADP), chemerin (CHEM), as well as the concentration of plasma citrulline (CIT) and the levels of thyroid hormones (T3 and T4) and thyroid-stimulating hormone (TSH) in the blood were measured at 21 and 42 days of age. A significant correlation (P < 0.01) was found between LRE supplementation and the decrease in serum VF, ADP, CIT, T3 and T4 levels in partridges exposed to HS. On the other hand, no significant relationship was found between LRE supplementation and the serum CHEM and TSH levels (P > 0.05). We concluded that the addition of 600 mg/kg LRE is beneficial in preventing intestinal damage and inflammation provoked by HS.
AtıfScopus13WoS14OpenAlex16İncele - MakaleYalnız künye2020Scopus SJRQ2Effect of Turkish Propolis on miRNA Expression, Cell Cycle, and Apoptosis in Human Breast Cancer (MCF-7) Cells
Misir, Sema; Aliyazicioglu, Yüksel; Demir, Selim; Turan, Ibrahim; Hepokur, Ceylan
Enriched in flavonoid compounds, phenol acids, and terpene derivatives, propolis has been shown to regulate apoptosis signaling pathways and alter the expression of microRNAs (miRNAs). In the present study, it has been aimed to examine the effects of Turkish propolis on miRNA levels of breast cancer (MCF-7) cells, and its relationship with cell proliferation and apoptosis. Cytotoxic activity of ethanolic propolis extract (EEP) was evaluated using MTT assay. Mechanisms involved in the cytotoxic action of Turkish propolis in MCF-7 cells were investigated with regard to apoptosis and cell cycle using flow cytometry and western blot. Mitochondrial membrane potential (MMP) were evaluated by spectrofluorometric method. miRNA levels were detected by qRT-PCR method. EEP exhibited selective toxicity against MCF-7 cells compared to normal fibroblast cells. EEP increased the cell cycle arrest at the G1 phase. EEP elevated the apoptotic cell death through increasing pro-apoptotic protein levels (p21, Bax, p53, p53-Ser46, and p53-Ser15), decreasing MMP and altering the expression levels of specific tumor suppressors (miR-34, miR-15a, and miR-16-5p) and oncogenic (miR-21) miRNAs. These data support that Turkish propolis may be evaluated as a potential natural agent for new anticancer drugs in future.
AtıfScopus42WoS43OpenAlex56İncele - MakaleYalnız künye2020Scopus SJRQ2Determination of geological structures by geophysical and geotechnical techniques in Kırklartepe Dam Site (Turkey)
Sari, Mahmut; Seren, Aysel; Alemdag, Selcuk
In foundation research of engineering structures, application of geophysics methods before drilling work allows not only more economical studies but also a more detailed determination of underground sections. Especially in pre-feasibility studies on long tunnel routes, dam sites and lake areas, it has a vital importance in terms of structural safety to determine possible underground buried fault lines, lithology changes, anticlinal-synclinal structures and underground openings. By considering these effective factors, the alluvium/bedrock border and the positions of potential buried faults in the dam site and lake area in the Kırklartepe area of the province of Bayburt in northeastern Turkey were determined by comparison with geophysical and geotechnical methods. First of all, the resistivity of the dam axis location and the change of the Vp wave velocity by depth were determined by comparing the results between geophysical methods of electrical resistivity tomography (ERT) and seismic refraction tomography (SRT), respectively. Afterwards, from the foundation boreholes opened in the dam axis location, joint frequency and the other parameters determined by observations were obtained. With these parameters, 2-dimensional zoning profiles of the dam axis location were formed, and the alluvium-bedrock border and the locations of the buried faults were determined. Two potential faults in the NW-SE direction relative to the location of the dam axis were clearly revealed in the zoning profiles obtained in the ERT and SRT measurements. Additionally, the presence of these faults was determined as a result of examining the separation and joint frequency parameters from the drilling core samples collected from the BH_3 and BH_5 boreholes opened in the investigated area based on changes in the vertical and horizontal directions. In addition to these, in the ERT study, two potential faults other than the determined two were also detected. It was seen in the zoning profiles that these faults corresponded to right under the BH_2 borehole and 60 m SW of the BH_6 drilling. Consequently, in the zoning studies conducted at the examined site, the change in the lithology at the dam axis by depth (alluvium-bedrock border), lateral correlations of boreholes and potential faults were determined. It was recommended for the selected dam axis location to be constructed at a more suitable place in the NW direction in terms of engineering. Furthermore, with this study, it was revealed once again that it is highly essential to use geophysical and geotechnical together in conceptualizing large engineering structure projects.
AtıfScopus29WoS25OpenAlex30İncele - MakaleYalnız künye2020Scopus SJRQ4Plasticity in behavior of Turkish malting barley cultivars under semi-arid and continental climatic conditions
Sirat, Abdulveli; Bahar, Bilge
This study aimed to select stable cultivars in terms of desired agronomic or quality criteria from among 15 two rowed barley cultivars that may remain stable in varying year conditions during 2014-2015 and 2015-2016. Furthermore, relationships among these traits were investigated. Some agronomical and quality traits of barley were affected by years and cultivars. Yield, yield components and some quality parameters were affected by the cultivars. Also, days to ripening was affected by years, cultivars, and year x cultivar interaction. Crude protein content (CPC) was significantly positive correlated with ASH during both seasons. Starch ratio (SR) showed significantly negative correlations with ASH and CPC during both seasons. ADF and NDF had significant positive strong correlation with one another and ASH during both years while they showed significant negative correlations with SR. The results show that technological properties are not affected by the interaction of cultivar x year; therefore, these stable cultivars can be readily used in malt or feed technology if their technological features are considered. For example, cv. Unver contained low ratios of ash, CPC, oil, soluble fiber and high SR in the malt industry; cv. Hasat which includes the opposite technological properties of cv. Unver, was found be suitable for use in feed technology.