Sürdürülebilir Kalkınma Amaçları

Yazarlar

  • BildiriYalnız künye2011
    The control of an automatic door using fuzzy logic

    Sümbül, Harun; Coşkun, Akif; Taşdemir, Muharrem

    In this paper; a fuzzy logic have designed to the control of an automatic door. Input status (WS: Walking Speed and DD: Distance Door) and the output status (DOS: Door Opening Speed) is determined. According to these statuses, rule bases (25 rules) have obtained. And the rules bases have been processed by a fuzzy logic and have tried to control of an automatic door. As a result; in this study, we have obtain very good results in control of an automatic door with fuzzy logic. The results of analyses have indicated that the controls performed with fuzzy logic provided both less time, less probability and reliable, consistent controls and that are feasible to in real.

    AtıfScopus8OpenAlex6
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  • MakaleYalnız künye2011Scopus SJRQ2
    A proficiency test scheme for the quality control of black tea and development of quality control material for internal quality control

    Baltaci, Cemalettin; Ilyasoǧlu, Huri; Sarikaya, Sevim Beyza Öztürk; Cavrar, Sevda; Yayli, Nurettin

    A proficiency test (PT) was organized for quality control analysis of black tea. Test materials for the analyses of total content of powder tea, moisture, total ash, acid-insoluble ash, water-soluble ash, alkalinity of water-soluble ash, water extract, crude fiber and caffeine were sent to the participant laboratories (n:43) in 2009. The assigned value, standard deviation of the parameters and z-scores of the participant laboratories were calculated using the data reported by the participants. The percentage of the reported results for analytes was found to be ranged from 67.5 to 100%. Acceptable z-scores were achieved by 80.5-97.5% of the participant laboratories. More than 15% of unacceptable results were obtained for acid-insoluble ash and caffeine analyses. The quality control material for quality control analysis of black tea was developed from the remaining material.

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  • MakaleYalnız künye2011Scopus SJRQ2
    Polyphenol contents and antioxidant properties of medlar (Mespilus germanica L.)

    Gülçin, Ilhami; Topal, Fevzi; Sarikaya, S. Beyza Öztürk; Bursal, Ercan; Bilsel, Gökhan; Gören, Ahmet C.

    Medlar is the fruit of Mespilus germanica L. in the family of Rosaceae. The present study outlines that the native medlar (Mespilus germanica L.) fruits an extremely rich source of antioxidants. In this study, antioxidant and antiradical property of medlar fruits were evaluated. Total phenolics and flavonoids amounts in lyophilized extract of medlar (LEM) fruits were calculated as gallic acid and quercetin equivalents, respectively. Antioxidant and radical scavenging activity of LEM were investigated using different in vitro assays including 1,1-diphenyl-2-picryl-hydrazyl (DPPH·), N,N-dimethyl-p-phenylenediamine (DMPD•+), and superoxide anion radicals (O2•-) scavenging activity, hydrogen peroxide (H2O2), ferric ions (Fe 3+) and cupric ions (Cu 2+) reducing ability, Fe 3+ -TPTZ reducing ability, ferrous ions (Fe2+) chelating activity as trolox equivalent. In addition, quantitative amounts of caffeic acid, ferulic acid, syringic acid, ellagic acid, quercetin, α-tocopherol, pyrogallol, p-hydroxybenzoic acid, vanillin, p-coumaric acid, gallic acid and ascorbic acid in LEM were detected by high performance liquid chromatography and tandem mass spectrometry (LC-MS/MS). The presence of these antioxidant compounds can be considered as a quality parameter for edible medlar fruits.

    AtıfScopus151WoS138
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  • MakaleAçık Erişim2011Scopus SJRQ1
    Early abyssal- and late SSZ-type vestiges of the Rheic oceanic mantle in the Variscan basement of the Sakarya Zone, NE Turkey: Implications for the sense of subduction and opening of the Paleotethys

    Dokuz, Abdurrahman; Uysal, Ibrahim; Kaliwoda, Melanie; Karsli, Orhan; Ottley, Chris J.; Kandemir, Raif

    The boundary between the Gondwana and Laurussia, or a terrane separated from it, is traced by a suture recording the closure of the Rheic ocean in the Pulur, Beyçam and Kurtoǧlu areas of the eastern Sakarya Zone of Turkey. Pulur lherzolite has a lower Cr# [100Cr/(Cr+Al)=5-37] of the spinel and slightly enriched flat medium-heavy rare earth element (M-HREE) whole-rock pattern typical for those of the fertile abyssal-type lherzolite. By contrast, the Beyçam harzburgite displays the mineralogical and geochemical features of a moderately depleted residue at a supra subduction zone (SSZ). Some of spinels from the Beyçam peridotites show TiO2 contents (0.15-0.48wt.%) identical to a later interaction with a melt of island-arc tholeiite (IAT) composition. Meta-basalt from the Beyçam area is the representative of such a melt and displays the whole-rock M-HREE pattern of a complementary product of the Beyçam harzburgite. Data presented in this study support the primarily northward directed closure of the Rheic ocean, but suggest that the Variscan basement in the eastern part of the Sakarya Zone consists of mantle peridotites formed in a south-vergent SSZ. This dual polarity of subduction in the Rheic ocean, at least in the second half of its closure, is also favored by the geological structure and lithological diversity of the Variscan rocks. These are: (1) spatial distribution of the peridotites, e.g., SSZ-type harzburgites to the north and abyssal-type lherzolites to the south, (2) lack of high-pressure metamorphic rocks, (3) decrease in the degree of Variscan metamorphism toward the north, and (4) emplacement of Variscan syn-collisional magmatism into the low grade metamorphic rocks to the north. Paleotethys was the other ocean of the region created in the Late Paleozoic. Northward subduction of the Rheic ocean from Early Devonian to Early Carboniferous appears to be the most plausible mechanism responsible for the opening of Paleotethys. In this scenario the Paleotethys is envisaged as a back-arc basin opened to the north in the wake of separated terranes from Laurussia. Onset of trench-Rheic mid-ocean ridge collision in the Early Devonian along the northern margin of Laurussia has been proposed to account for the initiation of SSZ-type subduction to the south. The short duration of this subduction appears insufficient to open a fully developed back-arc basin to the south because the elimination of Rheic mid-ocean ridge to the north accelerated the oceanic closure.

    AtıfScopus56WoS52OpenAlex51
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  • MakaleAçık Erişim2011Scopus SJRQ4
    Frequency optimization of laminated skewed open cylindrical shells

    Topal, Umut; Uzman, Ümit

    This paper deals with frequency optimization of symmetrically laminated skewed open cylindrical shells. The design objective is the maximization of the fundamental frequency and the design variable is the fiber orientations. The firstorder shear deformation theory (FSDT) is used for the finite element solution of the shells. The modified feasible direction (MFD) method is used for the optimization routine. For this purpose, a program based on FORTRAN is used. Finally, the numerical analysis is carried out to investigate the effect of skew angles, length to radius ratios, subtended angle and boundary conditions on, the optimal designs and the results are compared.

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  • MakaleYalnız künye2011Scopus SJRQ2
    Calc-alkaline I-type plutons in the eastern Pontides, NE Turkey: U-Pb zircon ages, geochemical and Sr-Nd isotopic compositions

    Kaygusuz, Abdullah; Şen, Cüneyt

    The Köprübaşi{dotless} intrusion from the eastern Pontides of NE Turkey consists of granodiorite and monzogranite, and contains a number of mafic microgranular enclaves (MMEs). We report here U-Pb zircon age, geochemical and Sr-Nd isotopic data for these rocks in order to determining magma sources and magma production processes. On the basis of U-Pb zircon sensitive high-resolution ion microprobe dating (SHRIMP), the magma emplacement age of the granodiorite is 79.3±1.4Ma. The rocks of the pluton are calc-alkaline, metaluminous to peraluminous characteristics, and display features of I-type granites. They are enriched in large ion lithophile elements (LILE) and light rare earth elements (LREE) with negative Eu anomalies (Eu/Eu*=0.60-0.76), but are depleted in high field strength elements (HFSE). They have small range of 87Sr/86Sr(i) (0.7067-0.7070) and e{open}Nd(i) (-3.2 to -4.4) values. Fractionation of plagioclase, hornblende and Fe-Ti oxides played an important role in the evolution of the Köprübaşi{dotless} intrusion. A relatively shallow intrusion depth (∼2-8km) was estimated from the Al-in-hornblende geobarometry. All these characteristics, combined with the low values of K2O/Na2O, SiO2, Al2O3/(FeOT+MgO+TiO2) and (Na2O+K2O)/(FeOT+MgO+TiO2), suggest an origin by dehydration melting from a metabasaltic lower crustal source.

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  • MakaleYalnız künye2011Scopus SJRQ3
    Petrogenesis of a Late Cretaceous composite pluton from the eastern Pontides: The Daǧbasi pluton, NE Turkey

    Kaygusuz, Abdullah; Aydingakir, Emre

    Zircon U-Pb ages, major and trace elements, and Sr-Nd isotope data are reported for the Late Cretaceous Dagbasi pluton from the eastern Pontides, NE Turkey. This pluton has calc-alkaline affinity and displays typical features of volcanic arc granitoids. It is a composite pluton consisting of tonalite, granodiorite, and monzogranite, all containing mafic microgranular enclaves (MMEs). Based on U-Pb zircon SHRIMP dating, magma emplacement ages of the tonalite, granodiorite, and monzogranite are 88.1 ± 1.7 Ma, 86.0 ±2.0 Ma, and 82.9 ± 1.3 Ma, respectively. The tonalites have low SiO2 (60-64 wt%) and display metaluminous to peraluminous characteristics. They have similar Lacn/Lucn (1.5-7.3) and Eu/Eu* (0.65-0.88) values compared to granodiorites and monzogranites. The isotopic signatures of these rocks εNd(i) = -1.4 to -1.7; 87Sr/86Sr(i) = 0.7056-0.7060) are largely similar to granodiorites and monzogranites. Samples from the granodiorites and monzogranites have SiO2 between 69 and 76 wt% and display peraluminous to slightly metaluminous characteristics. Chondrite-normalized REE patterns are characterized by moderate Lacn/Lucn ratios (1.6-7.1), with pronounced negative or positive Eu anomalies (Eu/Eu* = 0.46-1.11). Radiogenic isotope signatures of granodiorites and monzogranites show overlapping 87Sr/86Sr(i), (0.7057-0.7067) and εNd(i) (-3.2 to + 1.5) values. The MMEs have similar geochemical and isotopic features as the host rocks. All plutonic rocks are enriched in large ion lithophile elements (LILE) and light rare earth elements (LREE) relative to high field strength elements (HFSE). Fractionation of plagioclase, hornblende, and Fe-Ti oxides played an important role in the evolution of Daǧbasi granitoids. All these geochemical and isotopic characteristics suggest an origin by dehydration melting of an amphibolitic lower crustal source.

    AtıfScopus44WoS42OpenAlex45
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  • MakaleYalnız künye2011Scopus SJRQ1
    Modeling and forecasting of Turkey's energy consumption using socio-economic and demographic variables

    Kankal, Murat; Akpinar, Adem; Kömürcü, Murat Ihsan; Özşahin, Talat Şükrü

    This study deals with the modeling of the energy consumption in Turkey in order to forecast future projections based on socio-economic and demographic variables (gross domestic product-GDP, population, import and export amounts, and employment) using artificial neural network (ANN) and regression analyses. For this purpose, four diverse models including different indicators were used in the analyses. As the result of the analyses, this research proposes Model 2 as a suitable ANN model (having four independent variables being GDP, population, the amount of import and export) to efficiently estimate the energy consumption for Turkey. The proposed model predicted the energy consumption better than the regression models and the other three ANN models. Thus, the future energy consumption of Turkey is calculated by means of this model under different scenarios. The predicted forecast results by ANN were compared with the official forecasts. Finally, it was concluded that all the scenarios that were analyzed gave lower estimates of the energy consumption than the MENR projections and these scenarios also showed that the future energy consumption of Turkey would vary between 117.0 and 175.4. Mtoe in 2014.

    • SDG 7 · Erişilebilir ve Temiz Enerji
    • SDG 13 · İklim Eylemi
    AtıfScopus233WoS199OpenAlex282
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  • MakaleYalnız künye2011Scopus SJRQ1
    Dynamic Characteristics of a Prototype Arch Dam

    Sevim, B.; Bayraktar, A.; Altunışık, A.C.; Adanur, S.; Akköse, M.

    This study determines the dynamic characteristics of a prototype arch dam-reservoir-foundation system using Operational Modal Analysis method. Achievement of this purpose involved construction of a prototype arch dam-reservoir-foundation system under laboratory conditions. Ambient vibration tests on the arch dam model identified its natural frequencies, mode shapes, and damping ratios. Natural excitations such as small impact loads vibrated to arch dam. Sensitivity accelerometers which were placed on the dam's crest collected signals in measurements. Measurements were recorded for empty and full reservoirs. Operational Modal Analysis software processed signals which were collected from the ambient vibration tests. Enhanced Frequency Domain Decomposition technique estimated dynamic characteristics of the dam. Results showed that there was an approximate 20-25% difference between natural frequencies related to empty and full reservoirs.

    • SDG 9 · Sanayi, Yenilikçilik ve Altyapı
    AtıfScopus9WoS9OpenAlex8
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  • MakaleYalnız künye2011Scopus SJRQ2
    Preconcentration of Cd(II) and Cu(II) ions by coprecipitation without any carrier element in some food and water samples

    Duran, Celal; Ozdes, Duygu; Sahin, Deniz; Bulut, Volkan Numan; Gundogdu, Ali; Soylak, Mustafa

    A simple, rapid, sensitive and environmentally friendly separation and preconcentration procedure, based on the carrier element free coprecipitation (CEFC) of Cu(II) and Cd(II) ions by using an organic coprecipitant, 2-{[4-(4-fluorophenyl)-5-sulphanyl-4H-1,2,4-triazol-3-yl]methyl}-4-{[(4-fluorophenyl) methylene]amino}-5-(4-methylphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (MEFMAT) was developed. The analyte ions were determined by flame atomic absorption spectrometric (FAAS) determinations. The optimum conditions for the coprecipitation process were investigated on several commonly tested experimental parameters such as pH of the solution, amount of MEFMAT, sample volume, standing time, centrifugation rate and time. The influences of some anions, cations and transition metals on the recoveries of analyte ions were also investigated, and no considerable interference was observed. The preconcentration factor was found to be 50. The detection limits for Cu(II) and Cd(II) ions based on the three times the standard deviation of the blanks (N:10) were found to be 1.49 and 0.45μgL-1, respectively. The relative standard deviations were found to be lower than 3.5% for both analyte ions. The method was validated by analyzing two certified reference materials (CRM-TMDW-500 Drinking Water and CRM-SA-C Sandy Soil C) and spike tests. The procedure was successfully applied to sea water and stream water as liquid samples and tobacco, hazelnut and black tea as solid samples.

    • SDG 6 · Temiz Su ve Sanitasyon
    AtıfScopus56WoS54OpenAlex47
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  • MakaleAçık Erişim2011Scopus SJRQ1
    Modelling and mapping third dimension in a spatial database

    Döner, F.; Biyik, C.

    In this paper, an overview of phases for modelling and mapping third dimension of spatial objects in a database is presented based on a selected spatial database management system (DBMS). These phases include (1) defining a spatial reference system for representing three-dimensional (3D) objects with real-world coordinates, (2) geometric modelling of 3D objects in the database, (3) 3D spatial indexing for fast accessing/querying the 3D data, 3D spatial queries and representation of 3D data. Then, a case study is performed to assess needs, possibilities and potential limitations of 3D data modelling in the spatial database.

    AtıfScopus3WoS4OpenAlex4
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  • MakaleAçık Erişim2011Scopus SJRQ2
    Mild conditions for oxidation/epoxidation of styrene

    Kazanci, A.; Saribiyik, O.Y.; Serin, S.

    In this study, in order to obtain novel support materials for immobilization of transition metals, polymeric Schiff bases were synthesized using a poly-condensation reaction between ortho(o-)phthalaldehyde tere(t-)phthalaldehyde, oxaldehyde and diamines like, e.g., ethylene-p- phenylene- and o-phenylenediamine. Additionally, catalytic activity of polymeric Schiff base metal on oxidation/epoxidation of styrene complexes were investigated. The products have been characterized on the basis of analytical and spectral method, Fourier transform infrared spectroscopy, 1H- and 13C-nuclear magnetic resonance, gel-permeation chromatography, elemental analysis, thermogravimetric analysis, atomic adsorbtion spectrometry, gas chromatography and gas chromatography mass spectrometry.

    AtıfScopus3WoS3OpenAlex2
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  • MakaleAçık Erişim2011Scopus SJRQ3
    Factors of land use/cover change: A case study from Turkey

    Sivrikaya, Fatih; Çakir, Günay; Akay, Abdullah Emin

    Land use/cover change impacts ecosystem services and functions such as forest health, biodiversity, and water production. Monitoring and assessing land use/cover changes provides an effective and accurate evaluation of human impact on the forest ecosystems. This study aims to determine spatial and temporal changes in land use/cover at a particular time period in a typical forest ecosystem of Turkey using geographical information systems (GIS). Specifically, the objective of this study is to analyze the main factors driving land use/cover change and the impacts of such changes in local and global perspective. Results showed that the total forested areas decreased from 5089 ha (41% of the study area) to 4426 ha (36% of the study area) during a 21 year period, which figures a net decrease of 663 ha (5%) forest areas and the average annual deforestation rate was 32 ha. Conifer forest (161 ha) completely transitioned to other cover types over 21-year period. Three major factors including distance from villages, distance from roads, and ground elevation were considered in evaluating forest disturbance. The results showed that these factors influence the reforestation/deforestation rates. Besides, forest disturbance was found to be closely related to distance from villages, distance from roads, and elevation.

    • SDG 13 · İklim Eylemi
    • SDG 15 · Karasal Yaşam
    AtıfScopus9OpenAlex14
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  • MakaleYalnız künye2011Scopus SJRQ2
    Laparoscopic abdominoperineal resections for mid or low rectal adenocarcinomas: A retrospective, comparative study

    Gezen, Cem; Altuntas, Yunus E.; Kement, Metin; Okkabaz, Nuri; Bilici, Ahmet; Vural, Selahattin; Gumus, Mahmut; Oncel, Mustafa

    BACKGROUND: Laparoscopic abdominoperineal resection (APR) has been seldom studied apart from low anterior resections, and deserves to be separately analyzed. This study aims to compare perioperative and oncological outcomes of laparoscopic and conventional APRs performed for the treatment of mid and low rectal adenocarcinomas. MATERIALS AND METHODS: Patients operated for primary mid or low rectal adenocarcinoma between 2001 and 2009 in our institution were retrospectively investigated. These data were abstracted and compared within conventional and laparoscopic resection groups: demographics, tumor and procedure-related parameters, perioperative results, early oncological outcomes, and survival. RESULTS: Demographics and tumor and procedure-related parameters were similar within the laparoscopic (n=31) and conventional (n=36) groups, except intraoperative bleeding and requirement for transfusion, which were significantly lower after laparoscopic APRs. Perioperative results including complication, reoperation, and 30-day mortality rates were identical. Early oncological results and 3-year survival rates were alike. CONCLUSIONS: The perioperative results and oncological outcomes are similar after laparoscopic and conventional APRs. As current data include limited number of patients in a retrospective design, further studies comparing laparoscopic and conventional APR techniques are required.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus8WoS8OpenAlex9
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  • MakaleAçık Erişim2011Scopus SJRQ1
    Nonlinear earthquake behaviour of highway tunnels

    Sevim, B.

    This paper describes the Arhavi Highway Tunnel which has two tubes, its geometrical properties, finite element model, and the nonlinear earthquake behaviour under a huge ground motion considering soil-structure interaction. The Arhavi Highway Tunnel is one of the tallest tunnels constructed in the Black Sea region of Turkey as part of the Coast Road Project. The tunnel has two tubes and each of them is about 1000 m tall. In the study, the modal analyses of the tunnel considering soil-structure interaction are performed and natural frequencies and mode shapes are obtained. Then, nonlinear transient analysis of the tunnel using Drucker-Prager criteria is performed applying acceleration components of 1992 Erzincan, Turkey earthquake's ground motion. In the time history analyses, Rayleigh damping coefficients are calculated using main natural frequency obtained from modal analysis. Element matrices are computed using the Gauss numerical integration technique. The Newmark method is used in the solution of the equation of motion. Because too much memory for the analyses is required, the first 7.5 s of the ground motions, which is the most effective duration, is taken into account in calculations. The displacement and stress results are observed to be the allowable level of the concrete material.

    • SDG 9 · Sanayi, Yenilikçilik ve Altyapı
    • SDG 11 · Sürdürülebilir Şehirler ve Topluluklar
    AtıfScopus13WoS12OpenAlex12
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  • MakaleAçık Erişim2011Scopus SJRQ3
    4-[2-(Cyclohexa-1,4-dien-1-yl)ethoxy]-benzene-1,2-dicarbonitrile

    Keleşoǧlu, Zeynep; Çelenk Kaya, Elif; Kaya, Afşin Ahmet; Kantekin, Halit; Büyükgüngör, Orhan

    In the title compound, C16H14N2O, the dihedral angle between the aromatic rings is 70.23 (6)°. The linking chain has a zigzag conformation. In the crystal, molecules are linked by weak inter-molecular C - H⋯N hydrogen bonds, forming a zigzag chain along the c axis.

    AtıfScopus1WoS1OpenAlex1
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  • MakaleAçık Erişim2011Scopus SJRQ2
    Effect of Turkish propolis extracts on proteome of prostate cancer cell line

    Barlak, Yaşam; Deǧer, Orhan; Çolak, Meltem; Karatayli, Senem C.; Bozdayi, Abdurrahman M.; Yücesan, Fulya

    Background: Propolis is a natural, resinous hive product that has several pharmacological activities. Its composition varies depending on the vegetation, climate, season and environmental conditions of the area from where it was collected. Surface enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOF MS) is a proteomic approach which has been used in cancer proteomics studies. Prostate cancer is one of the most commonly diagnosed cancers in men. It has shown that nutritional supplements rich in polyphenolic compounds such as propolis play a significant role in prostate cancer chemoprevention. The aim of this study is to evaluate if protein expression profile in PC-3 prostate cancer cell lines could be differentiated when incubated with dimethyl sulfoxide and water extracts of Turkish propolis.Results: The antioxidant potentials of dimethyl sulfoxide and water extracts of propolis were found in correlation with the amount of total phenolic compounds of them. Dimethyl sulfoxide and water extracts of propolis of 20 μg/mL reduced the cell viability to 24.5% and 17.7%, respectively. Statistically significant discriminatory peaks between control PC-3 cells and dimethyl sulfoxide extract of propolis-treated PC-3 cells were found to be the proteomic features at m/z 5143, 8703, 12661, 20184 and 32794, detected by CM10 ProteinChip, and the peak at m/z 3772, detected by Q10 ProteinChip. Between control PC-3 cells and water extract of propolis-treated PC-3 cells, statistically significant discriminatory peaks were found to be the proteomic features at m/z 15846, 16052 and 24658, detected by CM10 ProteinChip and the peaks at m/z 10348, 10899 and 11603, detected by Q10 ProteinChip.Conclusions: It was concluded that dimethyl sulfoxide and water extracts of Turkish propolis may have anti-proliferative activity through differentiating protein expression profile in PC-3 prostate cancer cell lines along with their antioxidant capacity.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus57WoS50OpenAlex61
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  • MakaleAçık Erişim2011Scopus SJRQ2
    Arc magmatism as a window to plate kinematics and subduction polarity: Example from the eastern Pontides belt, NE Turkey

    Eyuboglu, Yener; Santosh, M.; Bektas, Osman; Ayhan, Seda

    The Eastern Pontides orogenic belt in the Black Sea region of Turkey offers a critical window to plate kinematics and subduction polarity during the closure of the Paleotethys. Here we provide a brief synthesis on recent information from this belt. We infer a southward subduction for the origin of the Eastern Pontides orogenic belt and its associated late Mesozoic-Cenozoic magmatism based on clear spatial and temporal variations in Late Cretaceous and Cenozoic arc magmatism, together with the existence of a prominent south-dipping reverse fault system along the entire southern coast of the Black Sea. Our model is at variance with some recent proposals favoring a northward subduction polarity, and illustrates the importance of arc magmatism in evaluating the geodynamic milieu associated with convergent margin processes.

    AtıfScopus47OpenAlex50
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  • MakaleAçık Erişim2011Scopus SJRQ3
    The relationship between the peroxisome proliferator-activated receptor gamma 2 gene polymorphism, lipids and adipokines in patients with major depression; [Majör depresyonlu hastalarda peroksizom çoǧaltici-aktive edici reseptör gama 2 gen polimorfizmi, lipidler ve adipokinlerle ilişkisi]

    Aliyazicioglu, Rezzan; Deǧer, Orhan; Vanizor Kural, Birgül; Hocaoǧlu, Çiçek; Çolak, Meltem; Balaban Yücesan, Fulya

    Objective: Peroxisome proliferator-activated receptor gamma (PPARγ), lipids, lipoproteins, and adipokines have recently been shown to be associated with psychiatric diseases. Our major aim is to investigate the contribution of the PPARγ gene polymorphism, adipokines, lipids, and lipoproteins to the development of major depression. Material and Methods: The frequency of Pro12Ala in exon 2 and C478T in exon 6 of the PPARγ gene, lipids and adipokines in major depression (n = 78) and control subjects (n= 64) were analyzed. Genotypes of PPARy gene polymorphisms were examined. Serum leptin, adiponectin, and resistin were studied by enzyme-linked immunosorbent assay (ELISA). Serum apo A1, apo B, and Lp(a) levels were determined by immunonephelometry. Serum total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol levels were analyzed by enzymatic methods. Results: The genotypes of exon 2 and exon 6 distribution did not differ between the control subjects and patients with major depression. Frequencies of genotypes of Pro12Ala, and Ala12Ala in exon 2 in overweight and obese patients with major depression were higher than those of overweight and obese controls. C478T polymorphism was highest in overweight and obese patients with major depression. Pro12Ala and Ala12Ala genotypes in exon 2 of PPARγ gene in patients were found to be associated with triglyceride and HDL-cholesterol. There were significant differences regarding glucose, total cholesterol, LDL-cholesterol, apo B, Lp(a), adiponectin and resistin levels between patient and control subjects. Conclusion: PPARγ exon gene polymorphisms, alterations in lipid profile and adipokines may be associated with the development of major depression.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus9WoS9OpenAlex10
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  • MakaleYalnız künye2011Scopus SJRQ1
    Kinetics and isotherm analysis of basic dyes adsorption onto almond shell (Prunus dulcis) as a low cost adsorbent

    Duran, Celal; Ozdes, Duygu; Gundogdu, Ali; Senturk, Hasan Basri

    The feasibility of using an agricultural byproduct, almond shell (Prunus dulcis), as an adsorbent in removal of basic dyes, namely, methylene blue (MB), methyl violet (MV), and toluidine blue O (TB), were evaluated in a batch adsorption process. The adsorption characteristics of MB, MV, and TB onto almond shell (AS) were investigated with respect to the changes in initial pH of dye solutions, contact time, initial dye concentration, and temperature. The dye adsorption equilibria were rapidly attained after 30 min of contact time. The adsorption kinetics were analyzed using pseudofirst-order, pseudosecond-order, Elovich, and intraparticle diffusion models and the adsorption data were well described by the pseudosecond-order model. The equilibrium adsorption data were interpreted in terms of the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich (D-R) isotherm models. The monolayer adsorption capacity of AS was found to be 51.02 mg·g-1 for MB, 76.34 mg·g-1 for MV, and 72.99 mg·g-1 for TB by using the Langmuir model equation. The thermodynamic parameters proved that the present adsorption process was feasible, spontaneous and endothermic in nature in the temperature range of (5 to 40) °C.

    • SDG 12 · Sorumlu Üretim ve Tüketim
    AtıfScopus284WoS260OpenAlex284
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