Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(77)
- Merdan, Mehmet(73)
- Duran, Celal(54)
- Ozdes, Duygu(50)
- Baltaci, Cemalettin(45)
- Kaygusuz, Abdullah(45)
- Kulakaç, Nurşen(39)
- Ashyralyyev, Charyyar(38)
- Karsli, Orhan(37)
- Demir, Selim(36)
- Öztürk, Serkan(36)
- Dokuz, Abdurrahman(35)
- Turan, Ibrahim(35)
- Araz, Onur(33)
- Kandemir, Raif(31)
- Sipahi, Ferkan(30)
- Topal, Fevzi(30)
- Kurt, Kemal(28)
- Peker, Iskender(28)
- Arslan, Mehmet(27)
- Baltacı, Cemalettin(27)
- Maden, Nafiz(27)
- Ozturk, Samet(27)
- Aydin, Aydanur(26)
- Vural, Alaaddin(26)
- Bayrakdaroglu, Serdar(25)
- Kurnaz, Muammer(25)
- Reis, Hatice Catal(25)
- Akar, Zeynep(24)
- Aydin, Faruk(24)
- Gücer, Mehmet Ali(24)
- Topal, Meryem(24)
- Yolcu, Halil(24)
- Yücel, Cem(24)
- Anaç, Halil(23)
- Kankal, Murat(23)
- Ürkek, Bayram(23)
- Aliyazicioglu, Yuksel(22)
- Günen, Mehmet Akif(22)
- Tuncer, Metin(22)
Yayınlar
- BildiriYalnız künye2017Scopus SJRQ3THE ROLE OF NATIONAL AND INTERNATIONAL GEOSPATIAL DATA SOURCES IN COASTAL ZONE MANAGEMENT
Bayram, Bulent; Avsar, Ozgur; Seker, Dursun Zafer; Kayi, Abdullah; Erdogan, Mustafa; Eker, Oktay; Janpaule, Inese; Reis, Hatice Catal
Coastline changes are increasing rapidly due to both natural and human effects. The expansion of touristic, industrial and culture fishing establishments through coastal areas has brought about uncontrolled and unplanned urbanization. In this study, the coastline in Karasu district of Turkey has been extracted by using Unmanned Aerial Vehicle (UAV) images. For this purpose; 7 cm ground sample distance (GSD) UAV images taken in 2013 by Gatewing-X100 by 40% side and 70% forward overlap was used as post images. Produced ortho images were used as the base map for extraction of the coastline. An object-oriented approach has been applied to capture the shoreline from these ortho images. In the presented study, the eCognition object-oriented fuzzy image processing software has been used. This commercial software has the ability to develop custom tools for image classification in addition to its standard object feature tools. Customized arithmetic features have been used to achieve more accurate shoreline segmentation results. Three main object classes have been created as sea, shoreline buffer and land to extract shoreline. The segmentation results were converted into dxf vector data format. The results were compared with manual digitizing of 55 blind readers. An algorithm has been developed by using Matlab to analyze the differences between object-oriented classification and manual digitizing results. Results were evaluated according to students' gender, age, spent time, used software and courses taken. The root mean square error (RMSE) was calculated as 7.15 m.
AtıfWoS9
İncele - MakaleAçık Erişim2017Nutmeg Intoxication Associated with Consumption as a Stupefacient
Günaydin, Mucahit; Tatli, Ozgur; Altuntas, Gurkan; Uslu, Zakire; Özsahin, Faruk; Beslioglu, Necla
Introduction: Nutmeg is the dried seed of an evergreen aromatic tree from the plant family Myristicaceae. It is widely used in traditional medicine. Although misuse is rare, it needs to be understood that this plant, widely used as a spice in various parts of the world, can be misused and can result in emergency presentation due to intoxication. Case Report: We describe a case of intoxication in a 22-year-old male student after he mixed nutmeg with fruit juice and drank it. Neurological symptoms and anticholinergic signs were present during presentation. Conclusion: Nutmeg intoxication must be one of the possibilities considered at differential diagnosis in patients presenting to the emergency department with findings of anticholinergic intoxication.
- MakaleAçık Erişim2017Diagnostic Value of Cyclophilin A in Acute Ischemic Stroke
Karaca, Yunus; Tatli, Ozgur; Eryigit, Umut; Aksüt, Nurhak; Sahin, Aynur; Mentese, Ahmet; Altay, Diler Us; Beslioglu, Necla; Karatas, Mevlut; Örem, Asim
Aim: The early diagnosis and treatment of patients presenting to the emergency department symptoms of stroke can significantly reduce mortality and morbidity rates associated with it. This study aimed to investigate the diagnostic value of serum yclophilin A levels in our study group who presented to the emergency department with symptoms of acute ischemic stroke. Materials and Methods: In total, 114 patients diagnosed with acute ischemic stroke between October 2013 and October 2014 and a control group of 66 healthy volunteers were included. Cyclophilin A levels in the patient and control groups were compared. Results: The median cyclophilin A levels in the patient and control groups measured at the time of presentation were 13.47 (11.97-17.92) ng/mL and 11.54 (8.48-16.22) ng/mL, respectively. These levels were significantly higher in the patient group than in the control group (p<0.05). Conclusion: Plasma cyclophilin A levels were significantly higher in the patient group than in the control group.
- MakaleYalnız künye2017Scopus SJRQ3Carbonic anhydrase I and II autoantibodies in Behcet's disease
Mentese, A.; Alver, A.; Demir, S.; Sumer, A.; Yaman S, Ozer; Karkucak, M.; Capkin A, Aydin; Us, Altay D.; Turan, I
Background: Behcet's disease ( BD) is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase ( CA) is a metalloenzyme which is widely distributed in the living world, and it is essential for the regulation of acid-base balance. Anti-CA antibodies have been reported in many disorders, such as systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, endometriosis, idiopathic chronic pancreatitis, type 1 diabetes and Graves' disease. The goal of this study was to investigate CA I and II autoantibodies in BD. Methods: 35 patients with BD and 29 healthy controls were included in the study and CA I and II autoantibody levels were investigated by ELISA. Results: The CA I and II autoantibody levels of BD group were significantly higher than the healthy group (p= 0.013, p= 0.0001, respectively). A cut-off value of 0.250 absorbance unit (ABSU) for anti-CA I was associated with 34% sensitivity and 100% specificity and a cut-off value of 0.171 ABSU for anti-CA II was associated with 54% sensitivity and 100% specificity for predicting BD. Conclusion: The CA I and II autoantibody levels in pa-tients with BD were found higher compared to control group and the results suggest that CA I and II autoantibodies may be involved in the pathogenesis of BD
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İncele - MakaleYalnız künye2017Scopus SJRQ1Petrogenesis of ultramafic rocks from the eastern Orhaneli ophiolite, NW Turkey: Hints on the initiation and evolution of melt-peridotite interaction processes within a heterogeneously depleted mantle section
Uysal, Ibrahim; Dokuz, Abdurrahman; Kapsiotis, Argyrios; Saka, Samet; Karsli, Orhan; Kaliwoda, Melanie; Mueller, Dirk
The eastern Orhaneli ophiolite in NW Anatolia (Turkey) consists of voluminous dunite and minor harzburgite intruded by clinopyroxenite veins. Harzburgite contains spinel of low Cr# [100 x Cr/(Cr + Al) = 40-45] and diopside of low Al2O3 and TiO2 contents, whereas dunite contains spinel of higher Cr# (62-82) and diopside (blebs) (even more) depleted in Al2O3 and TiO2 (than harzburgite). The concentrations of Heavy Rare Earth Elements (HREE) in harzburgite are consistent with derivation of this type of peridotite from 19% dry melting of a fertile mantle protolith at a MOR regime. Dunites have lower concentrations of HREE than harzburgite implying that dunites were generated by higher degrees (> 30%) of (cumulative) melting of the same protolith. Furthermore, the characteristic U-shapes of the chondrite-normalized REE-patterns of dunites indicate the involvement of hydrous melt-peridotite interaction processes in their genesis. Nevertheless, a set of mosaic-in texture dunite samples contain olivine that has lower Fo# [100 x Mg/(Mg + Fe2+)] and NiO contents than olivine in harzburgite. These dunites are probably of cumulate origin as it is also indicated by their enrichment in Pt and Pd (<= 17.92 ppb). Micro-textural and Re-Os isotopic data support that clinopyroxenite intrusions do not have a pure magmatic origin and their formation was partly controlled by metasomatic processes. Overall data indicate that the eastern Orhaneli ultramafic rocks have a complex petrological history including various stages of partial melting, metasomatism and magmatism in an evolving from MOR to SSZ geotectonic setting.
AtıfScopus17WoS14OpenAlex15İncele - MakaleAçık Erişim2017Scopus SJRQ4Synthesis of some natural sulphonamide derivatives as carbonic anhydrase inhibitors
Gokcen, Taner; Al, Melike; Topal, Meryem; Gulcin, Ilhami; Ozturk, Turan; Goren, Ahmet C.
Carbonic anhydrase inhibitor; sulphonamides; p-hydroxybenzoic acid; 3,4,5-trihydroxybenzoic acid (gallic acid).Carbonic anhydrase inhibitors are both in clinical use as antiglaucoma, diuretics, antiepileptics and management of altitude sickness, and under investigation as anticancer, anticonvulsant and antiobesity agents. Sulphonamides have been known for decades as carbonic anhydrase inhibitors and are in clinical use. Sulphonamide derivatives of p-hydroxybenzoic acid and 3,4,5-trihydroxybenzoic acid (gallic acid) were synthesized and their inhibition values over hCA I and hCA II isozymes, purified from human erythrocyte cells by Sepharose-4B-L-tyrosine-sulphanilamide, were determined. Compounds synthesized showed efficient carbonic anhydrase inhibition activity at low nM levels.
AtıfScopus27WoS24OpenAlex27İncele - MakaleAçık Erişim2017Scopus SJRQ3Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands
Ayvaz, Melekcol; Turan, Ibrahim; Dural, Bayram; Demir, Selim; Karaoglu, Kaan; Aliyazicioglu, Yuksel; Serbest, Kerim
Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) transition metal complexes of 2-hydroxy-5-[(E)-(4-phenyl) diazenyl] benzaldehyde oxime and 2-hydroxy-5-[(E)-(4-nitrophenyl) diazenyl] benzaldehyde oxime ligands were synthesized and characterized through NMR, IR, ESI mass, and UV analysis. DNA binding abilities of the complexes were revealed using a UV-Vis spectrophotometer with the absorption titration and competitive binding techniques. Hydrolytic and oxidative DNA cleavage activities under different conditions were also proved. Topoisomerase I inhibition efficiencies and in vitro free radical scavenging activities of all complexes were examined. Finally, the selective cytotoxic potentials of all complexes were evaluated in human colon cancer, normal colon, and fibroblast cell lines using the water-soluble tetrazolium salt (WST-1) assay. The complexes had the ability to intercalate into stacked base pairs of DNA and topoisomerase I activity was reasonably inhibited in their presence in 0.4 mM concentrations. The abilities for scavenging of DPPH and hydroxyl radicals were found to be higher than those of known standard antioxidants (ascorbic acid, butylated hydroxyanisole, and mannitol). The results obtained from the cytotoxicity experiments are especially promising for further research, which must be carried out for the evaluation of the studied complexes as anticancer drugs.
AtıfScopus8WoS8OpenAlex8TR Dizin2
İncele - MakaleAçık Erişim2017Scopus SJRQ2Accumulation of phenolics in natural and micropropagated plantlets of Thymus pseudopulegioides Klokov & Des.-Shost. with their antioxidant potentials
Günaydin, Mustafa; Laghari, Abdul Hafeez; Bektas, Ersan; Sökmen, Munevver; Sökmen, Atalay
Thymus pseudopulegioides plantlets were propagated in vitro via direct organogenesis by using Murashige and Skoog (MS) media containing kinetin, thidiazuron, and 6-benzyladenine (BA) individually. Methanol extracts obtained both from plantlets and wild plants were analyzed for their total phenolics and flavonoid contents, then quantified by HPLC. The highest total phenolic (8.83 mg/g as gallic acid equivalent) and total flavonoid (0.92 mg/mL as rutin equivalent) values were from the MS media supplemented with 1.0 mg/L kinetin and 0.5 mg/L BA, respectively. The plantlets grown in those media also showed remarkable antioxidant activities with an IC50 value of 4.77 mu g/mL in DPPH and 100% inhibition in beta-carotene assays, respectively. HPLC analysis proved the production of protocatechuic, caffeic, vanillic, rosmarinic, ferulic, and o-coumaric acids and rutin. Rosmarinic acid production was predominant in natural samples (115.2 mg/100 g dry weight), while the aforesaid phenolic acids were prevalent in plantlets grown on MS media supplemented with KIN or BA at various concentrations. Rutin production was the highest (50.74 mg/100 g dry weight) in the plantlets grown on MS medium containing kinetin (1.0 mg/L). As an economically important chemical, rosmarinic acid was selected as the target chemical and a novel method was introduced to achieve its selective isolation.
AtıfScopus6WoS5OpenAlex9TR Dizin2İncele - MakaleYalnız künye2017Scopus SJRQ2Microindentation on the porous copper surface modulations
Ekmekci, Dursun; Yilmaz, Fikret; Kölemen, Ugur; Cora, Omer Necati
This study aimed to investigate the mechanical properties of a surface modulation which was realized through compaction, and then sintering of copper powders. To this goal, Berkovich type of indenter and depth-sensing indentation technique were used in microindentation to measure the hardness and modulus of elasticity values at different features of compact. Indentations were performed with a peak force of 50 mN. Hardness values were obtained in 0.88-1.12 GPa range while the modulus of elasticity was recorded in the 70-111 GPa interval. Even though both modulus of elasticity and hardness values were noted to be different for copper powders and substrate, one-way ANOVA analyses showed that the differences in both modulus of elasticity and hardness values are insignificant. FE modeling of microindentation was also performed and validated. It was shown that the force-displacement values obtained from FE analyses are quite well in agreement with the experimental data.
AtıfScopus4WoS5OpenAlex4İncele - Yüksek Lisans TeziAçık Erişim2016Human capital and economic growth relation: Case of Turkey
Fikret Onur Elma
This study examines the relationship between human capital and economic growth for Turkey. Human capital is described with two different variables as schooling rate and ratio of bachelors to total population. Therefore, within the scope of two different models the impact of human capital on economic growth is analyzed long/short termed. Relationships are analyzed with cointegration and causation analysis. According to analysis results schooling rate and ratio of bachelors to total population in Turkey do not have positive correlation in long term. This result is suprising in terms of expectations. However, under production of high tech product export is taken into consideration when comparing with developing countries, it's an expected result. In short term the ratio of bachelors to total population is found as Granger causation of economic growth. These results are expected to provide insight to those who decide educational policy.
- MakaleYalnız künye2016Validation of HPLC Method for the Determination of 5-hydroxymethylfurfural in Pestil, Köme, Jam, Marmalade And Pekmez
Akşit, Zeynep; Baltaci, Cemalettin
T his study represents a high performance liquid chromatography (HPLC) method for the detection of 5-hydroxymethylfurfural in pestil, köme, jam and pekmez samples. The linearity, selectivity, decision limit, detection capability, detection limit, quantification limit, precision, recovery, ruggedness and measurement uncertainty of the method were determined. The developed method, simple and accurate, showed good recovery values (97-108%). The accuracy of the method expressed with the relative standard deviation was below 6%. The detection limit and quantification limit were 0.03 mg/kg and 0.10 mg/kg, respectively. HMF levels in pestil, köme, jam, marmalade and pekmez samples were determined using the validated method
AtıfTR Dizin5İncele - MakaleYalnız künye2016Chemical Composition, Antimicrobial and Antioxidant Activities of Essential Oil from Pedicularis condensata BIEB
İlter, Şeyda Merve; Baltaci, Cemalettin; Üçüncü, Osman
T he chemical composition of the essential oil obtained from the dried aerial parts of Pedicularis condensata was analyzed by GC-FID and GC-MS. Thirty-eight components have been identified in the essential oil of P. condensata. The major compounds of the essential oil were pentacosane (21.28%), hexadecanoic acid (18.48%) and tricosane (13.70%). The antimicrobial activity of the essential oil was also investigated and it showed moderate antimicrobial and antifungal activites aganist twelve gram negative bacteria and five fungi. The amount of total phenolic and DPPH reducing activity quantified essential oil in P. condensata were found as 198.28 GGA/L and 10.90 % respectively
- MakaleYalnız künye2016Sustainability Organic Agriculture and Livestock Production with Respect to European Union in Eastern Anatolia and East Black Sea Regions
Altun, Hilal Ürüşan; Haşimoğlu, Sümer; Aksakal, Vecihi; Cengiz, Mahir Murat; Erdoğan, Yaşar; Bayram, Bahri; Dellal, Gürsel
The majority of farm households in Turkey and especially the Eastern Anatoliaare still based on low-input semi subsistence agriculture and livestock production. Despite a slow decline in recent years, agriculture and livestock production remains a major employer in Turkey and it is a significant contributor to the country's gross domestic product, GDP. Whist Turkey is one of the EU candidate countries, is self sufficient in food production and Turkish agriculture is poorly structured inefficient, with farming in the Eastern Anatoliabeingmainlysubsistencefarming. Yet,thesetraditionalruralstructures combined with poor access to low level of education and low level of off-farm unemployment problem makes the situation more complicated and unsustainable. The best way to promote sustainability, better and higher production of Eastern Anatolian and rural Turkey is to invest in the local people, villages through improved, continuing and effective agricultural and livestock programs in particular.Investment in human capital especiallyintheruralareasleadstomoreemploymentopportunitiesthrough entrepreneurship and innovation in organic agriculture and livestock production. A holistic approach to developing and improving supply chains could unlock the potential forsophisticated,state-of-the-artorganicagricultureandlivestockproducersand businesses in the region to become EU and global players. Eastern Anatolian livestock producers and the farmers have the ambitions to take part in future progress because the region is naturally organic not by design but default.It is for sure that present potential of the region has not been fully determined and utilized. EU has greatly benefited from previous enlargements economically, politically and socially. When European Union (EU) and Turkish Government relations considered and accession of Turkey to EU would be the logical consequence of the previous accessions. The screening on chapter 11 (Agriculture and rural development) is one of the important criteria and Turkey is working on to meet these benchmarks.
AtıfTR Dizin2İncele - BildiriYalnız künye2016Scopus SJRQ1Immobilization and characterization of urease onto different spacer arms attached magnetic nanoparticles
Yucebilgic, Guzide; Gulesci, Nuri; Yildirim, Deniz
AtıfOpenAlex2İncele - Derleme MakaleYalnız künye2016Scopus SJRQ3Characterization of the Combustion Parameters of Impregnated and Varnished Cedar Wood (Cedrus libani)
Fidan, M. Said; Yasar, S. Sadiye; Yasar, Mehmet; Atar, Musa; Alkan, Elif
The present study investigated the effect of various types of impregnating and surface treatment materials on the fire resistance of wood material indoors and outdoors. Wood samples (Cedrus libani A. Rich.) were impregnated with Wolmanit-CB or Tanalith-E according to ASTM D1413-76 (American Society for Testing and Materials 1976). The impregnated surface was treated with either synthetic or water-based outdoor varnish materials. The impregnated and varnished samples were left in outdoor conditions for 1 year. The combustion characteristics of the samples were investigated at the end of 1 year according to the combustion parameters detailed in the ASTM E160-50 (1975) combustion test. The results of this study indicated that the combustion parameters were lower in the 1-year-old samples (89.12% of control values), in the samples impregnated using Wolmanit-CB (89.18% of control values), and in samples treated using water-based varnish (88.43% of control values). The analysis of flue gas indicated that the O-2 content of the 1-year-old samples impregnated with Wolmanit-CB and treated with synthetic varnish was higher, whereas the CO content was lower. In conclusion, impregnated Wolmanit-CB specimens provide higher fire resistance.
AtıfWoS6OpenAlex4İncele - BildiriYalnız künye2016HIGH SCHOOL STUDENT FINANCIAL LITERACY ACCORDING TO SCHOOL TYPE
Semercioglu, M. Serhat; Akcay, Ahmet Oguz; Cingula, M; Vlahov, RD; Dobrinic, D
Financial literacy is a concept that contains knowledge and skills to be acquired by people, enables the accurate use, accumulation, increase, and management of incomes, and directly affects both national and international economies. Knowledge of individuals regarding financial concepts and their applications are of vital importance regarding financial decisions that would be made in every moment of life. This study examined the financial literacy levels of high school students, who contain the young population of society. A one-way ANOVA was conducted to determine differences between school types. The result shows that Science High Schools had the highest financial literacy level.
- BildiriYalnız künye2016Scopus SJRQ1The effects of gallic acid on the acute necrotizing pancreatitis in rats
Kural, B.; Altay, D. Us; Kahraman, C.; Alhan, E.; Sen, T. Mazlum; Ercin, C.; Kent, N. Kucuk; Kara, H.; Kör, S.; Örem, A.
- MakaleYalnız künye2016Scopus SJRQ2Assessment of Left Atrial Mechanics in Patients with Preexcitation Syndrome Scheduled for Catheter Ablation
Karakoyun, Suleyman; Tanboga, Ibrahim Halil; Gökdeniz, Tayyar; Lazoglu, Zakir; Topçu, Selim; Karal, Huseyin; Aksakal, Enbiya; Sevimli, Serdar
ObjectivesWe aimed to test the left atrial (LA) mechanics and contraction synchrony by 2D strain imaging, in patients with Wolff-Parkinson-White (WPW) syndrome, before and after radiofrequency catheter ablation (RFCA). MethodsStudy population consisted of 25 patients with WPW scheduled for RFCA and 30 healthy controls. The peak LA strain at the end of the ventricular systole (LAs strain) and the LA strain with LA contraction (LAa Strain) were obtained. To assess LA dyssynchrony, septal versus lateral wall time-to-peak strain measurements were measured. ResultsThere was no difference between the patients with WPW and control subjects with regard to peak LAs and LAa strain. Patients with WPW demonstrated higher global time-to-peak LAs and LAa strain values compared with the control group. Peak LAs strain and LAa strain values, measured before and after the RF ablation of the accessory pathway, were comparable (34.33.92 vs. 34.6 +/- 3.2, P=0.816, 14.7 +/- 2.8 vs. 15.3 +/- 2.3, P=0.052, respectively). Global time-to-peak LAs and LAa strain measurements were significantly shorter after the RFCA compared with the values obtained before the RFCA. However, septo-lateral times to peak LA strain differences were found to be comparable in both WPW versus control and pre- versus postablation groups. ConclusionLA mechanical function assessed by 2D strain imaging was comparable between patients with WPW and control subjects. Patients with WPW had more prominent LA dyssynchrony during atrial pump phase as compared with the controls, a condition which could not improve after successful elimination of the accessory pathway by RFCA.
AtıfWoS3OpenAlex2İncele - MakaleAçık Erişim2016Scopus SJRQ2Mechanical Bowel Preparation Does Not Affect Anastomosis Healing in an Experimental Rat Model
Piroglu, Isilay; Tulgar, Serkan; Thomas, David Terence; Cakiroglu, Basri; Piroglu, Mustafa Devrim; Bozkurt, Yasin; Gergerli, Ruken; Ates, Nagihan Gozde
Background: Mechanical bowel preparation before colorectal surgery is commonly performed, but its benefits are controversial. The aim of this study was to compare the effects of mechanical bowel preparation on healing of colonic anastomosis and tissue strength. Material/Methods: After institutional review board approval, 20 adult Wistar albino rats were randomly divided into 2 groups of 10 animals each. Mechanical bowel preparation including sodium phosphate was performed on the experimental group via a feeding tube, whereas no bowel preparation procedures were performed on the control group. Transverse colon resection and anastomosis were performed on all rats under general anaesthesia. On postoperative day 5, re-laparotomy was performed and the anastomotic areas were resected. Animals were killed, after which bursting pressure and tissue hydroxyproline concentrations were measured, histopathological examination was performed, and we evaluated and compared the results. Results: There were no differences between control and experimental groups in bursting pressure, tissue hydroxyproline concentrations, or histopathological examination results (P>0.05). Conclusions: Our study demonstrated no significant difference between bursting pressures, tissue hydroxyproline levels, or modified wound healing score at postoperative day 5 between rats undergoing and not undergoing mechanical bowel preparation. Mechanical bowel preparation is not essential for healing or strength of colonic anastomosis in rats.
AtıfWoS5İncele - MakaleYalnız künye2016Scopus SJRQ1Abnormal white matter integrity as a structural endophenotype for bipolar disorder
Sariçiçek, A.; Zorlu, N.; Yalin, N.; Hidiroglu, C.; Çavusoglu, B.; Ceylan, D.; Ada, E.; Tunca, Z.; Özerdem, A.
Background. Several lines of evidence suggest that bipolar disorder (BD) is associated with white matter (WM) pathology. Investigation of unaffected first-degree relatives of BD patients may help to distinguish structural biomarkers of genetic risk without the confounding effects of burden of illness, medication or clinical state. In the present study, we applied tract-based spatial statistics to study WM changes in patients with BD, unaffected siblings and controls. Method. A total of 27 euthymic patients with BD type I, 20 unaffected siblings of bipolar patients and 29 healthy controls who did not have any current or past diagnosis of Axis I psychiatric disorders were enrolled in the study. Results. Fractional anisotropy (FA) was significantly lower in BD patients than in the control group in the corpus callosum, fornix, bilateral superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, anterior thalamic radiation, posterior thalamic radiation, cingulum, uncinate fasciculus, superior corona radiata, anterior corona radiata and left external capsule. In region-of-interest (ROI) analyses, we found that both unaffected siblings and bipolar patients had significantly reduced FA in the left posterior thalamic radiation, the left sagittal stratum, and the fornix compared with healthy controls. Average FA for unaffected siblings was intermediate between the healthy controls and bipolar patients within these ROIs. Conclusions. Decreased FA in the fornix, left posterior thalamic radiation and left sagittal stratum in both bipolar patients and unaffected siblings may represent a potential structural endophenotype or a trait-based marker for BD.
AtıfWoS45İncele
