Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(77)
- Merdan, Mehmet(73)
- Duran, Celal(54)
- Ozdes, Duygu(50)
- Baltaci, Cemalettin(45)
- Kaygusuz, Abdullah(45)
- Kulakaç, Nurşen(39)
- Ashyralyyev, Charyyar(38)
- Karsli, Orhan(37)
- Demir, Selim(36)
- Öztürk, Serkan(36)
- Dokuz, Abdurrahman(35)
- Turan, Ibrahim(35)
- Araz, Onur(33)
- Kandemir, Raif(31)
- Sipahi, Ferkan(30)
- Topal, Fevzi(30)
- Kurt, Kemal(28)
- Peker, Iskender(28)
- Arslan, Mehmet(27)
- Baltacı, Cemalettin(27)
- Maden, Nafiz(27)
- Ozturk, Samet(27)
- Aydin, Aydanur(26)
- Vural, Alaaddin(26)
- Bayrakdaroglu, Serdar(25)
- Kurnaz, Muammer(25)
- Reis, Hatice Catal(25)
- Akar, Zeynep(24)
- Aydin, Faruk(24)
- Gücer, Mehmet Ali(24)
- Topal, Meryem(24)
- Yolcu, Halil(24)
- Yücel, Cem(24)
- Anaç, Halil(23)
- Kankal, Murat(23)
- Ürkek, Bayram(23)
- Aliyazicioglu, Yuksel(22)
- Günen, Mehmet Akif(22)
- Tuncer, Metin(22)
Yayınlar
- MakaleYalnız künye2016Scopus SJRQ2Simplified Early Stopping Criterion for Belief-Propagation Polar Code Decoders
Simsek, Cemaleddin; Turk, Kadir
As the first theoretically proven capacity-achieving error correction code, polar codes have become a milestone in information theory field, which draw serious attention by its low complexity encoding and decoding structures. For the decoding section, studies are focused on efficient and low complex algorithms based on successive cancellation and belief-propagation (BP) decoders. To reduce computational complexity of BP-based decoders further, early stopping methods that avoid unnecessary iterations can be used. In this letter, we propose a reduced complexity early stopping method for BP-based polar code decoders. The proposed method is based on the hypothesis that observing only a small cluster of information bits polarized to the highest error probabilities is enough to detect successful decoding. Simulation results show that the proposed early stopping criterion significantly reduces the computational complexity of successful decoding detection as well as the total operation numbers of the whole decoding process compared with previous methods in the literature.
AtıfScopus45WoS41OpenAlex47
İncele - BildiriAçık Erişim2016A Study on the Performance of GPR for Detection of Different Types of Buried Objects
Toksoz, Derya; Yilmaz, Isik; Seren, Aysel; Mataraci, Isil; Salame, C.; Aillerie, M.; Papageorgas, P.
The objective of this research is to evaluate the applicability of Ground Penetrating Radar (GPR) method to detect burried objects in the shallow depths using 250 MHz and 800 MHz center frequency antennas. For this purpose, different objects were burried in several places of a certain test site. GPR data were collected along six paralel profiles using 250 MHz and 800 MHz antennas which are compatible with RAMAC CU II system. The reflections profile data were processed using the computer program ReflexW. After the processing of data, the reflected /scattered reflections on the processed radargrams were examined and the radargrams were interpreted to determine the depths and positions of the objects from the surface. Also, the data obtained from 250 and 800 MHz antennas were compared and the differences between them in terms of resolution were discussed.
AtıfScopus7WoS2OpenAlex4İncele - MakaleYalnız künye2016Scopus SJRQ1Logistics center site selection by ANP/BOCR analysis: A case study of Turkey
Peker, Iskender; Baki, Birdogan; Tanyas, Mehmet; Murat Ar, Ilker
Site selection for logistics centers is one of the most strategic decisions in logistics. This study addresses the problem of logistics center site selection, using Analytic Network Process/Benefits, Opportunities, Costs and Risks, which is a multi-criteria decision making technique. The decision problem is applied to the city of Trabzon, which is an important city of the Eastern Black Sea Region in Turkey. First, the results are evaluated in terms of each sub-network and each group and, next, are consolidated for each alternative. They yield that Alternative A is the most appropriate logistics center location of all in Trabzon. Furthermore, the sensitivity analysis results emphasize that the decision model is robust.
AtıfScopus40WoS34OpenAlex45İncele - BildiriAçık Erişim2016The comparison of performance by using alternative refrigerant R152a in automobile climate system with different artificial neural network models
Kalkisim, A.T.; Hasiloglu, A.S.; Bilen, K.; Durak, R.; Tuzemen, S.
Due to the refrigerant gas R134a which is used in automobile air conditioning systems and has greater global warming impact will be phased out gradually, an alternative gas is being desired to be used without much change on existing air conditioning systems. It is aimed to obtain the easier solution for intermediate values on the performance by creating a Neural Network Model in case of using a fluid (R152a) in automobile air conditioning systems that has the thermodynamic properties close to each other and near-zero global warming impact. In this instance, a network structure giving the most accurate result has been established by identifying which model provides the best education with which network structure and makes the most accurate predictions in the light of the data obtained after five different ANN models was trained with three different network structures. During training of Artificial Neural Network, Quick Propagation, Quasi-Newton, Levenberg-Marquardt and Conjugate Gradient Descent Batch Back Propagation methodsincluding five inputs and one output were trained with various network structures. Over 1500 iterations have been evaluated and the most appropriate model was identified by determining minimum error rates. The accuracy of the determined ANN model was revealed by comparing with estimates made by the Multi-Regression method.
AtıfScopus1OpenAlex2İncele - BildiriYalnız künye2016Determination of the dynamic characteristics of the faculty building of law at KTU campus with HVSR and FSR methods
Bekar, Y.; Coban, K.H.; Sayil, N.
Seismic response characteristics of structures can be estimated by spectral ratios of microtremors measured on structures and their foundation ground surface. The microtremor horizontal-To-verticalspectral- ratio (HVSR) technique has received great attention from all over the world with its simplicity together with quick information about dynamic characteristics of ground and structures. The HVSR of microtremors gives a good estimation of natural building frequency. In this study, Horizontal-To-Vertical- Spectral-Ratio HSVR method and Floor Spectral Ratio Method (FSR) has been applied to microtremor records taken with three component broad band velocity seismometers in three different locations inside the building and one at outside with the aim of determining the dynamic characteristics of Faculty building of Law at The Karadeniz Technical University (KTU), in Turkey. The average predominant frequency, period and amplification values for the Faculty building of Law are calculated. The vibration frequency and period is around 3.5 Hz and 0.283 s, respectively. The amplitude values increase to the upper floors.
- MakaleAçık Erişim2016Scopus SJRQ2Kinetic and in silico studies of hydroxy-based inhibitors of carbonic anhydrase isoforms I and II
Ekhteiari Salmas, Ramin; Mestanoglu, Mert; Durdagi, Serdar; Sentürk, Murat; Kaya, A. Afşin; Kaya, Elif Çelenk
A series of hydroxy and phenolic compounds have been assayed for the inhibition of two physiologically relevant carbonic anhydrase (CA, EC 4.2.1.1) isozymes, the cytosolic human isozymes I and II. The investigated molecules showed inhibition constants in the range of 1.07-4003 and 0.09-31.5 μM at the hCA I and hCA II enzymes, respectively. In order to investigate the binding mechanisms of these inhibitors, in silico studies were also applied. Molecular docking scores of the studied compounds are compared using three different scoring algorithms, namely Glide/SP, Glide/XP and Glide/IFD. In addition, different ADME (absorption, distribution, metabolism and excretion) analysis was performed. All the examined compounds were found within the acceptable range of pharmacokinetic profiles.
AtıfScopus10WoS11OpenAlex15
İncele - MakaleYalnız künye2016Scopus SJRQ1Subduction-related Late Carboniferous to Early Permian Magmatism in the Eastern Pontides, the Camlik and Casurluk plutons: Insights from geochemistry, whole-rock Sr–Nd and in situ zircon Lu–Hf isotopes, and U–Pb geochronology
Karsli, Orhan; Dokuz, Abdurrahman; Kandemir, Raif
Late Carboniferous to early Permian granitoid rocks represent a volumetrically minor component of the Eastern Pontide lithosphere, but they preserve useful information about the region's tectonomagmatic history. The Casurluk and Camlik plutons primarily consist of gabbro, gabbroic diorite, diorite, monzogabbro, monzodiorite and monzonite, which intrude early to middle Carboniferous granitic basement rocks in the region. In this study, we use in situ zircon U–Pb ages and Lu–Hf isotopic values, whole-rock Sr–Nd isotopic values, and mineral chemistry and geochemistry of these plutons to determine petrogenesis and crustal evolution; we also discuss geodynamic implications. LA–ICP-MS zircon U–Pb dating of magmatic zircons from the rocks suggests that the plutons were emplaced during the late Carboniferous to early Permian (302 Ma). The metaluminous and I-type intrusive rocks belong to the high-K calc-alkaline series. In addition, they are relatively enriched in light rare earth elements (LREEs) and large-ion lithophile elements (LILEs); they are depleted in heavy rare earth elements (HREEs) and high field strength elements (HFSEs), such as Nb and Ti. All of the samples have homogeneous initial ISr values (0.70675 to 0.70792) and low εNd (t) values (− 5.1 to − 3.3). Zircons from the rocks of both plutons have uniform negative to slightly positive εHf (t) values (− 3.5 to 1.4) and old Hf two-stage model ages (1323 to 1548 Ma), implying that they have the same source, as well as suggesting the involvement of old enriched lithospheric mantle materials during their magma genesis. These results, combined with the εHf (t) values and two-stage model ages, demonstrate that the primary magmas were derived from partial melting of old lithospheric mantle material metasomatized by subduction-related fluids. Considering other regional geological data from the Sakarya Zone where these plutons formed, we conclude that late Carboniferous to early Permian magmatism in the area involved the partial melting of a phlogopite- and spinel-bearing lherzolite under an extensional regime in a subduction-related setting. Such an extension event would have caused hot asthenospheric upwelling and was likely triggered by back-arc rifting during subduction of the Paleo-Tethyan oceanic slab. Thus, the magmas are likely subduction-related products, implying that southward subduction of Paleo-Tethys oceanic lithosphere in the region began during the late Carboniferous to early Permian.
AtıfScopus59WoS55OpenAlex65İncele - MakaleAçık Erişim2016Scopus SJRQ2Kinetic characterization of GES-22 β-lactamase harboring the M169L clinical mutation
Saral, Aysegul; Leonard, David A; Duzgun, Azer Ozad; Cicek, Aysegul Copur; June, Cynthia M; Sandalli, Cemal
The class A β-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a structure that is known to have major effects on substrate selectivity in class A β-lactamases, we expressed, purified and kinetically characterized this novel variant. Our results show that compared with GES-116×His, GES-226×His displays more efficient hydrolysis of penicillins, and aztreonam, but a loss of efficiency against ceftazidime. In addition, the M169L substitution confers on GES-22 more efficient hydrolysis of the mechanistic inhibitors clavulanic acid and sulbactam. These effects are highly similar to other mutations at the homologous position in other class A β-lactamases, suggesting that this methionine has a key structural role in aligning active site residues and in substrate selectivity across the class.
AtıfScopus5WoS4OpenAlex5İncele - MakaleAçık Erişim2016Scopus SJRQ2Determining the Effect of Seasonal Variation in Spruce (Picea orientalis L.) Wood Treated with Various Impregnations on Combustion Resistance
Yasar, Ş. Şadiye; Fidan, M. Said; Yaşar, Mehmet; Atar, Musa; Alkan, Elif
Prepared test specimens were surface treated and coated with synthetic and water-based outdoor varnishes after being chemically impregnated. The test specimens were left outdoors to determine the effects of impregnation and treatment on the wood during each of the four seasons. Caucasian spruce (Picea orientalis L.) test specimens were prepared and combustion analyses were performed. As a result of the combustion test, weight loss results, as compared with the control, were 89% lower in the spring specimens, 90% lower with impregnation, and 90% lower with the synthetic varnish coating. Furthermore, the O2 amount during combustion was found to be the highest in combustion with a flame source in the winter specimens (21%). The CO2 amount was the highest in combustion without a flame source for full-year specimens (20%). The CO amount was the highest in combustion without a flame source of full-year specimens (31,787 ppm), and the NO amount was the highest during glowing of full-year specimens (55 ppm). Final results showed impregnation with Tanalith-E and water-based varnish coating to be the most effective fire protective treatments.
AtıfScopus5WoS5OpenAlex3İncele - MakaleYalnız künye2016Scopus SJRQ2Influence of CrN Coating on Electrochemical Behavior of Plasma Nitrided Pure Titanium in Bio-simulated Environment
Çelik, Ilhan
Titanium and its alloys are widely used as materials for bio-medical applications, such as implants. However, ions of the alloy can release to the body region and spread into the blood circulation. In this study, plasma nitriding and CrN coating techniques are used in order to overcome the problem of ion release. The objective of this study was to investigate the effects of plasma nitrided pure titanium on the structural properties and corrosion behaviors before and after CrN coating in Ringer's solution at 37 °C. The structural properties were investigated using Scanning Electron Microscopy (SEM) and X-ray diffraction (XRD). A diffusion layer and a compound layer composed of δ-TiN and ε-Ti2N phases were observed on the surface of nitrided pure titanium. Corrosion tests were made for the determination of electrochemical properties with the help of Potentiostat/Galvanostat device. The results show that corrosion behaviors of untreated and treated samples have similar characteristic.
AtıfScopus19WoS15OpenAlex19İncele - MakaleAçık Erişim2016Scopus SJRQ3Investigation of structural and tribological properties of duplex surface treated pure titanium
Çelik, I.; Karakan, M.
Commercial pure titanium (CP-Ti) is used in many engineering fields because of its superior properties such as excellent corrosion resistance, high strength/weight ratio, and biocompatibility. However, it is not available at the desired rate, since the CP-Ti has poor wear resistance. For this reason, many surface treatments have been applied to improve the poor tribological properties of the CP-Ti. In this study, duplex surface treatments, which are the combination of treatments of electroless Ni-B coating and plasma nitriding, were applied on the surfaces of the CP-Ti. Structural properties of the different surfaces of the treated materials were investigated using scanning electron microscopy (SEM) and X-ray diffraction (XRD). Microhardness measurements were made for the determination of mechanical properties and the pin-on-disk wear tests were made to determine the tribological properties. It was observed that poor wear resistance of the CP-Ti was improved with duplex surface treatments. The results showed that surface hardness, friction coefficient, and surface roughness of coated samples were better than of uncoated CP-Ti.
AtıfScopus7WoS5OpenAlex6İncele - MakaleAçık Erişim2016Scopus SJRQ3Determination of stand structure in even-aged oriental beech forests in Turkey; [Determinación de la estructura de rodales de Fagus orientalis coetáneos en Turquía]
Kahriman, Aydın; Altun, Lokman; Güvendi, Engin
This study aimed at developing a stand yield model for even-aged and pure Oriental beech (Fagus orientalis) stands in Sinop Province, located in the north of Turkey. The data used in this study were obtained from 238 sample plots. The sample plots are 24–131 years of stand age range, 19.0–35.9 m of site index range, and 2.2–10.8 of stand density range (relative density index). With the generated equation systems, stand age, site index and density of the three main factors in Oriental beech stands, including the effects of individual, dual and triple factor interactions on the stands were numerically determined. As for even-aged Oriental beech stands, the main stand volume values increase depending on age, site index and density. The number of stems per hectare decreases as the stand grows older, and site index rises; the number, however, increases in parallel with stand density. The current annual volume increment reaches a peak at 30-35 years at all site index groups and density levels, and begins to fall afterwards. Mean annual volume increment peaks up at 65-75 years at all site index classes and density levels, before beginning to decline. The results were in arrangement with the acknowledged growth rules. Stand yield models were assessed as Density-Variable Yield Table used for estimation of the remaining, removal and total stands.
AtıfScopus4WoS3OpenAlex1İncele - MakaleAçık Erişim2016Scopus SJRQ2Diversity and ecology of benthic algae in Karagöl Lake, Karagöl-Sahara National Park (Şavşat, Artvin, Turkey)
Akar, Bülent; Şahın, Bülent
Benthic algal flora of Karagöl Lake, its seasonal variation, and the physical and chemical parameters of the water were studied between October 2008 and September 2010. The algal flora consisted of 112 taxa belonging to the divisions Charophyta (41), Chlorophyta (33), Cyanobacteria (18), Euglenozoa (17), Miozoa (2), and Ochrophyta (1). Six desmid taxa found in this research are new records for the freshwater algal flora of Turkey. The qualitative dominance of benthic taxa typical of slightly alkaline and mesotrophic ecosystems was observed. The qualitative and seasonal variations in epipelic taxa analyzed were dependent on the physicochemical characteristics of the water. Water quality was analyzed on the basis of benthic taxa, which are bioindicators. The physicochemical properties of the water are suitable for the development of a rich algal flora (especially desmids). According to the benthic algal composition and indicator species, it is estimated that Karagöl Lake has mesotrophic lake characteristics. This is the first study of benthic algal flora of Karagöl Lake and marks a significant contribution to the knowledge of Karagöl-Sahara National Park’s aquatic biodiversity.
AtıfScopus5WoS3OpenAlex3TR Dizin1
İncele - BildiriYalnız künye20163D shoreline extraction using orthophoto and LiDAR data
Bayram, Bulent; Demir, Nusret; Ogurlu, Mustafa; Reis, Hatice Catal; Seker, Dursun Zafer
Shorelines are complex ecosystems and vital socio-economic environments. They may change rapidly due to both natural and human-induced effects. Determination of movements along the shoreline and monitoring of the changes are indispensable for many purposes such as coastline management, agriculture, decision support systems etc. Thus, rapid, up-to-date and accurate information are required to monitor the shorelines. In this study, the Kestel Dam Lake has been selected for evaluation and testing of the methods which will be used for the research project, about shoreline extraction with use of UAV-Based LIDAR data in the region of Terkos-Istanbul, which supported by TUBITAK (The Scientific and Technological Research Council of Turkey) with project nr. 115-718. Kestel Dam is located on the river of Kestel that is constructed for the irrigation purposes, built between 1983 and 1988. Irrigation capacity of dam is about 4077 ha of agricultural areas. The used dataset is LIDAR data which is provided by HGK (Turkish General Command of Mapping). In this study, two different methods are applied with use of LIDAR data, acquired in 2013. One method is mean-shift segmentation and the other is Particle Swarm Optimization Analysis (PSO). The results are both compared with manually created reference vector dataset which is created using orthoimage dataset. The results shows that the developed methods have potential to give success in the research project which will be performed in the region of Terkos which is the study area of the project.
AtıfScopus4İncele - MakaleAçık Erişim2016Scopus SJRQ3Existence and uniqueness theorems for sequential linear conformable fractional differential equations
Gökdoğan, Ahmet; Ünal, Emrah; Çelik, Ercan
Recently, a new definition of fractional derivative called as the conformable fractional derivative which based on limits introduced by Khalil et al (2014). Later, Abdeljawad (2015) improved these definitions and gave the basic concepts in this new fractional calculus. In this paper, we generalize Abel's formula and Wronskian determinant definition and establish existence and uniqueness theorems for sequential linear conformable fractional differential equations.
AtıfScopus27WoS26OpenAlex40İncele - MakaleYalnız künye2016Scopus SJRQ1U–Pb zircon chronology and petrogenesis of Carboniferous plutons in the northern part of the Eastern Pontides, NE Turkey: Constraints for Paleozoic magmatism and geodynamic evolution
Kaygusuz, Abdullah; Arslan, Mehmet; Sipahi, Ferkan; Temizel, İrfan
Numerous intrusive rocks of varying ages and compositions exist in the Paleozoic to Tertiary periods in the Eastern Pontides. Carboniferous intrusive rocks are commonly observed in the southern part of the Eastern Pontides. The nature of the rocks in the northern part of the region has not been determined because of Upper Cretaceous and Tertiary volcano-sedimentary units. Whole-rock geochemical, isotopic and geochronological data obtained from five different mapped granitoid bodies located in the northern part of the Eastern Pontides allow for the proper reconstruction of Carboniferous magmatism and the geodynamic evolution of the region. According to laser ablation ICP-MS U–Pb zircon dating, the Özdil, Soğuksu, Seslikaya, Kızılağaç and Şahmetlik plutons have similar 206Pb/238U vs. 207Pb/235U concordia ages of 340.7 ± 1.8 Ma and 323.1 ± 1.5 Ma, 348.4 ± 1.6 Ma, 335.4 ± 1.4 Ma, 337.2 ± 0.6 Ma and 334.5 ± 1.4 Ma, respectively. The aluminium saturation index (ASI) values of all of the samples from the plutons are between 1.0 and 1.32, which indicate peraluminous melt compositions. The plutons have SiO2 contents between 59 and 79 wt.% and show low- to high-K calc-alkaline characteristics. The plutons are enriched in large-ion lithophile and light rare earth elements and are depleted in high-field strength elements. Chondrite-normalized rare earth element patterns are characterized by concave-upward shapes and pronounced negative Eu anomalies, with LaCN/YbCN = 1.9–46.8 and EuCN/Eu* = 0.19–1.76. The studied plutons show considerable variations in 87Sr/86Sr(i) (0.70255 to 0.71006) and εNd(i) values (− 4.8 to − 7.1), as well as Nd model ages (1.15 to 2.47 Ga). The Pb-isotopic ratios are 206Pb/204Pb = 17.11–18.60, 207Pb/204Pb = 15.58–15.64 and 208Pb/204Pb = 36.95–38.62. The crystallization temperatures of the melts range from 676 to 993 °C, as determined by zircon and apatite saturation thermometry. These data suggest that the Carboniferous granitic magmas were produced by the partial melting of meta-mafic to meta-felsic lower crustal source rocks, with minor contributions from the mantle. Collectively, these rocks represent a late stage of Hercynian magmatism in the northern part of the Eastern Pontides.
AtıfScopus90WoS84OpenAlex97İncele - MakaleYayıncıda açık erişim2016Scopus SJRQ1Modeling deformation modulus of a stratified sedimentary rock mass using neural network, fuzzy inference and genetic programming
Alemdag, S.; Gurocak, Z.; Cevik, A.; Cabalar, A.F.; Gokceoglu, C.
This paper investigates a series of experimental results and numerical simulations employed to estimate the deformation modulus of a stratified rock mass. The deformation modulus of rock mass has a significant importance for some applications in engineering geology and geotechnical projects including foundation, slope, and tunnel designs. Deformation modulus of a rock mass can be determined using large scale in-situ tests. This large scale sophisticated in-situ testing equipments are sometimes difficult to install, plus time consuming to be employed in the field. Therefore, this study aims to estimate indirectly the deformation modulus values via empirical methods such as the neural network, neuro fuzzy and genetic programming approaches. A series of analyses have been developed for correlating various relationships between the deformation modulus of rock mass, rock mass rating, rock quality designation, uniaxial compressive strength, and elasticity modulus of intact rock parameters. The performance capacities of proposed models are assessed and found as quite satisfactory. At the completion of a comparative study on the accuracy of models, in the results, it is seen that overall genetic programming models yielded more precise results than neural network and neuro fuzzy models.
AtıfScopus113WoS110OpenAlex108İncele - MakaleYalnız künye2016Scopus SJRQ3Students understanding of mathematics using from prototypical examples: Analyze in linear algebra
Aydin, Sinan; Akkan, Yaşar
Mathematical objects are ʼnatural objects’ for the practical mind. Definitions and theories can only describe them, not create or construct them. A mathematical term is interpreted through its denotation as representing a collection of particular objects for the theoretical mind. So, theoretical and practical modes of thinking differ in the manner in which they constitute the meanings of words. Thinking in terms of prototypical examples, rather than definitions, became an obstacle to our students’ understanding the notion of linear transformation. In the course, linear transformations were defined as transformations of vector spaces which conserve linear combinations. The obstacle was revealed in the students’ attempts ‘linear extension problem’: given a transformation of a basis, to construct a linear transformation with those values on the basis. In the experimental course, the problem was not formulated in such general terms. It was restricted to two dimensions, and the students were not asked to ‘linearly extend a transformation from a basis to the whole plane’ but to assume the existence of such an extension and find some missing information about it. In this study we are discussing students understanding of mathematical concepts by means of linear transformation in linear algebra.
- MakaleAçık Erişim2016Scopus SJRQ2Effect of Turkish pollen and propolis extracts on caspase-3 activity in myeloid cancer cell lines
Uçar, Meltem; Değer, Orhan; Gerigelmez, Asuman Yiğit; Cengiz, Sevil; Barlak, Yaşam; Ovalı, Ercüment
Purpose: To investigate the apoptosis-inducing capacity of dimethyl sulfoxide (DMSO) extracts of bee pollen and propolis in HL-60 Myeloid Cancer Cell Lines. Methods: DMSO extracts of pollen and propolis were incubated separately with HL-60 cells, and caspase-3 activity evaluated. In order to determine the cell cycle characteristics of HL-60 cells with and without extracts of pollen and propolis, the cells were analysed using flow cytometry. Results: The DMSO extract of propolis (0.5 mg/mL) increased apoptosis from undetectable levels to 60.1%, while maintaining cell viability. The DMSO extract of pollen (2 mg/ml) increased apoptosis from undetectable levels to 52.2% while decreasing cell viability by 62%. Caspase-3 activity in HL-60 cells incubated with DMSO extracts of pollen and propolis were 3.6-to 12-fold higher than in controls. Conclusion: Turkish pollen and propolis individually increase apoptosis and the activity of caspase-3 in HL-60 cells. This finding indicates that bee products may have beneficial effects in the treatment of cancer.
AtıfScopus12WoS10OpenAlex12İncele - BildiriYalnız künye2016An assessment on the recent seismicity in the north anatolian fault zone, Turkey
Özturk, S.; Sari, M.
A statistical assessment of recent seismicity in the North Anatolian Fault Zone, Turkey, is made by using seismotectonic b-value and precursory seismic quiescence Z-value. The catalogue including 28,420 earthquakes between 1970 and 2016 is used. Using the Reasenberg declustering process and the earthquakes with MD≥2.7, 51.4% of the events are removed and so, 13,815 events are used for a quantitative evaluation of seismic quiescence in the NAFZ in the beginning of 2016. Completeness magnitude is estimated as 2.7. Resulting values show that significant anomalies are observed in both band Z-values in some parts of the NAFZ. The larger b-values are calculated in Silivri, Black Sea, Izmit and Düzce whereas the smaller b-values are estimated in the western, the eastern and the middle parts of the NAFZ, covering Gulf of Saros, Gelibolu (Çanakkale), Ismetpasa segment, Bingöl, Erzincan, Amasya and Çankiri. Several quiescence regions in and around Tekirdag, Gulf of Saros, Istanbul, Marmara and Black Sea, Izmit, Düzce fault, Mudurnu, Çankiri, Amasya are observed. Consequently, the same regions including Gulf of Saros, Çankiri and Amasya where the smallest b-values and the largest Z-values are obtained may give important evidences to reveal the future earthquake potential in the North Anatolian Fault Zone.