Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Sezer, İsmet(10)
- Hintistan, Sevilay(9)
- Türkkan, Tuğba(8)
- Odaci, Hatice(7)
- Aydin, Aydanur(5)
- Kurnaz, Muammer(5)
- Abada, A.(4)
- Abbrescia, M.(4)
- Abramov, A.(4)
- Aiba, M.(4)
- Aielli, G.(4)
- Akyürek, Suat(4)
- Auchmann, B.(4)
- Benedikt, M.(4)
- Demirağ, Hatice(4)
- Koçak, Tevfik(4)
- Yolcu, Halil(4)
- Abdolmaleki, H.(3)
- Abidi, S. H.(3)
- Adam, C.(3)
- Ady, M.(3)
- Adzic, P. R.(3)
- Agapov, I.(3)
- Aguglia, D.(3)
- Ahmed, I.(3)
- Akan, T.(3)
- Akchurin, N.(3)
- Akturk, D.(3)
- Aleksa, M.(3)
- Aleksan, R.(3)
- Alioli, S.(3)
- Ambrosio, G.(3)
- Arslan, Adem(3)
- Bartmann, W.(3)
- Bor, Hakan(3)
- Burnet, J. P.(3)
- Carli, C.(3)
- Chancé, A.(3)
- Craievich, P.(3)
- Giovannozzi, M.(3)
Yayınlar
- Derleme MakaleYalnız künye2026Biopsychosocial dimensions of cancer and spiritual coping strategies: a phenomenological study of patient experiences
Aydın, E; Uzun, S; Karakaş, S; Günay, D; Büyükçerçi, NN
- Derleme MakaleAçık Erişim2026Gender and Mental Health: Challenges Faced by Women and a Feminist Perspective
Türkkan, Tuğba; Odaci, Hatice
Mental health issues affect millions of people worldwide, leading to negative outcomes in various areas such as academic achievement, job performance, and quality of life. Women are known to be more prone to mental health problems than men, a phenomenon explained by biological sensitivity, genetic and hormonal differences, physiological stress responses, and exposure to environmental risk factors. However, research examining the impact of gender roles on mental health remains limited. Gender roles shape individuals' thought patterns, self-esteem, and emotion regulation strategies, making them significant factors that can influence mental health. In this context, the study aims to explore the effects of gender norms on mental health from a feminist perspective and evaluate the role of gender-based antecedents in this process through a review of the current literature. The study findings reveal that traditional gender roles negatively affect women’s mental health, while approaches promoting equality yield positive outcomes. Enhancing women’s access to education and economic independence is a crucial step toward reducing gender-based inequalities. Additionally, implementing gender equality policies and increasing inclusive representations in the media can mitigate the adverse effects on mental health. Education, awareness campaigns, and supportive social policies have the potential to reduce the impact of gender roles and improve individuals’ mental health. This study aims to guide effective mental health policies and targeted interventions.
- Derleme MakaleAçık Erişim2026Afet Direnci Kavramını Anlamak: Direnç Göstergeleri Üzerine PRISMA Yöntemiyle Sistematik Bir İnceleme
Peker, İskender; Ozbey, Sümeyye
Doğal ve beşerî faktörlerin bir araya gelmesiyle oluşan afetler, toplumların güvenliği, sürdürülebilir kalkınması ve yaşam kalitesi üzerinde ciddi tehditler oluşturmaktadır. Afetlerin önlenebilmesi veya etkilerinin azaltılabilmesi, toplumların ve kurumların afet direncinin artırılmasıyla doğrudan ilişkilidir. Afetlere dirençli toplumlar, afetlerle karşı karşıya kaldıklarında daha az kayıp yaşamakta, daha hızlı toparlanabilmekte ve yeniden işlevsel hale gelebilmektedir. Afetlerin etkilerinin azaltılması ve toplumsal hazırlığın artırılması amacıyla toplumsal afet direnci kavramına literatürde yer verilmiş olmasına rağmen bu kavrama ilişkin teorik çerçeve sınırlıdır. Kavramın tanımlanması, etkileyen faktörlerin belirlenmesi, hangi yöntemlerle değerlendirilebileceği açık değildir. Bu çalışma, söz konusu kavramsal boşluğu doldurmak amacıyla PRISMA yöntemi kullanılarak kapsamlı bir literatür analizi gerçekleştirmekte ve toplumsal afet direncine dair metodolojik bir çerçeve sunmaktadır. Analiz sonucunda, afetlere karşı kırılganlığın azaltılması için dirençlilikle ilişkili mevcut çalışmalar sistematik biçimde değerlendirilmiş, ayrıca bu kavramın ölçülebilmesi için kullanılabilecek bir dizi ilke ve gösterge sunulmuştur. Sonuç olarak çalışma, afetlere karşı kırılganlığı azaltmaya ve sürdürülebilir bir afet yönetimi yaklaşımı geliştirmeye katkı sunacak kavramsal ve pratik öneriler ortaya koymaktadır.
- Derleme MakaleAçık Erişim2026Nanoplastic Translocation Across Biological Barriers (Blood-Brain, Placental, Intestinal): Transport Mechanisms, Tissue-Specific Vulnerabilities, and a Corona-Driven Barrier Selectivity Framework
Berber, Ahmet Ali; Yildiz, Esra; Berber, Nurcan; Kurnaz, Muammer; Kenanoglu, Nihan Akinci
Nanoplastics (NPs; <= 1 & micro;m) have been detected in human placenta, blood, lung, atherosclerotic plaque, testis, semen, olfactory bulb, and brain, shifting the field from environmental description toward mechanistic interrogation of barrier crossing. This review synthesises current evidence on NP translocation across the intestinal epithelium, the blood-brain barrier (BBB) and the placental syncytiotrophoblast. We distinguish four evidence categories throughout the review: detection, association, mechanism, and causality. We also apply model-system labels (in silico, in vitro, ex vivo, animal, and human) to every mechanistic claim, so that the strength of each statement can be read off directly. Most current studies use pristine polystyrene nanoplastics at concentrations 3-6 orders of magnitude above plausible human exposure, so the mechanistic conclusions below are hypothesis-generating for human disease rather than definitive. We propose a working conceptual framework-corona-driven barrier selectivity (CDBS)-in which the particle-corona-surface complex, rather than the bare polymer, is hypothesised to dictate which receptor and transport machinery (TfR1, LRP1, FcRn, P-gp/BCRP, caveolae) each barrier engages. CDBS is offered as a hypothesis-stage organising tool requiring experimental validation, not as an established mechanism. We outline reported transport modes, including clathrin- and caveolin-mediated endocytosis, paracellular leakage via ROS-induced tight-junction disassembly, receptor-mediated transcytosis, and the candidate olfactory route. We emphasise that pristine polystyrene-bead doses commonly exceed plausible human exposure by 3-6 orders of magnitude, that detection methods underestimate sub-micrometre particles, and that causal links between NPs and human disease remain hypothesis-generating. A research agenda built on weathered reference materials, microphysiological systems, and integrative human biomarker science is proposed.
- Derleme MakaleAçık Erişim2026Microplastic Contamination in Amphibians and Reptiles: An Ecotoxicological Synthesis of Exposure, Mechanisms, and Risk Implications
Berber, Ahmet Ali; Akbulut, Cansu; Demir, Sefika Nur; Kurnaz, Muammer
Microplastic (MP) contamination has become a defining feature of twenty-first century environmental change, yet the toxicological and ecological consequences for amphibians and reptiles-two vertebrate classes already facing severe extinction pressures-remain fragmented across taxa, regions, and methodological traditions. Here, we synthesize field and experimental evidence from five continents to provide a taxonomically balanced, mechanistically grounded, and geographically explicit assessment of MP exposure, bioaccumulation, and toxicity in herpetofauna, drawing on a structured literature search in Web of Science, Scopus, and PubMed (January 2015-March 2026). Field detection rates of MPs in amphibian larvae range from 26% in conservatively screened Central European populations to 73-80% in anuran tadpoles from high-anthropogenic-pressure Anatolian catchments, with fibrous polyethylene terephthalate (PET), polyethylene (PE), and polypropylene (PP) particles dominating the detected burden. Mechanistic evidence converges on oxidative stress cascades, hypothalamic-pituitary-thyroid axis disruption, gut and cutaneous microbiome dysbiosis, and compromised antiviral and antifungal immunity, with the latter potentially amplifying vulnerability to Batrachochytrium dendrobatidis and to ranavirus. Among reptiles, sea turtles display near-universal MP ingestion with documented maternal transfer to eggs; freshwater turtles, terrestrial squamates, and crocodilians remain critically understudied. Three structural asymmetries constrain current ecotoxicological risk characterization: taxonomic bias toward anurans and sea turtles, geographic bias toward the Global North, and experimental bias toward acute, supra-environmental laboratory exposures using pristine, single-polymer particles that fail to capture the chemical complexity of weathered field mixtures. We argue that MP burden may warrant consideration as a candidate stressor criterion within IUCN Red List assessments and within environmental risk assessment frameworks for freshwater and terrestrial biodiversity once a robust quantitative relationship between MP burden and demographic decline or population-level fitness has been established, and propose six hypothesis-driven research priorities: methodological standardization, reptile toxicokinetics, transgenerational epigenetics, MP-pathogen microbiome interactions and their translation into population viability models, temperature & times; MP interaction under climate warming, and population-genetic consequences of contemporary MP-driven selection, as the most tractable avenues for ecotoxicological progress and for the development of herpetofauna-specific risk characterization frameworks.
- Derleme MakaleAçık Erişim2026The effect of non-pharmacologic treatments in individuals with problematic pornography use: a meta-analysis of randomized controlled trials
Yıldız Karaahmet, Aysu; Bilgiç, Fatma Şule; Karakaş, Sevda
This study aimed to systematically review and meta-analyze the effects of non-pharmacological treatments on problematic pornography use (PPU), pornography use frequency, sexual dysfunction, psychological symptoms, and quality of life in individuals with PPU. A comprehensive literature search was conducted in PubMed/MEDLINE, Embase, PsycINFO, and Web of Science between June and July 2024. MeSH-based keywords were used to identify relevant Randomized Controlled Trials (RCTs) published in the last ten years. Five RCTs with a total of 826 participants were included. Non-pharmacological interventions significantly reduced PPU (SMD: −1.16; 95% CI: −2.10 to −0.22; p = 0.02) and pornography use frequency (SMD: −0.74; 95% CI: −1.43 to −0.05; p = 0.04) compared to control groups. No statistically significant effects were found for sexual dysfunction (SMD: −0.47; p = 0.05) or psychological symptoms (SMD: −0.42; p = 0.06), though moderate effects were observed. Risk of bias was high or unclear in terms of participant and outcome blinding. Non-pharmacological interventions appear effective in reducing PPU and use frequency. Although effects on sexual function and psychological symptoms were not significant, the findings suggest potential improvements in overall quality of life.
- Derleme MakaleYalnız künye2026Marine microsporidia: Hidden diversity, aquatic emergence and zoonotic risks
Bekircan, Çağrı; Kurnaz, Muammer
Marine Microsporidia represent an increasingly important but historically underestimated group of aquatic intracellular parasites. Although traditionally associated with invertebrates and fishes, recent molecular and environmental studies have revealed extensive hidden diversity across marine ecosystems together with unexpected phylogenetic links between aquatic and human-associated lineages. This review synthesizes five decades of research (1975–2025) concerning the biology, evolution, taxonomy, host–pathogen interactions, ecological diversity, and zoonotic significance of marine Microsporidia. Particular emphasis is placed on members of the Enterocytozoonidae, including Enterocytozoon hepatopenaei, Nucleospora spp., and Desmozoon lepeophtherii, which represent major threats to aquaculture sustainability and may contribute to cross-environmental transmission pathways. Environmental DNA studies further indicate that marine microsporidian diversity is substantially underestimated by morphology-based approaches. However, current evidence for zoonotic transmission remains largely indirect, resting chiefly on phylogenetic relatedness, shared genotypes across hosts and environmental (eDNA) detection; direct, seafood-borne human infection has not yet been demonstrated. Current evidence suggests that aquaculture intensification, climate-driven environmental change, and expanding seafood trade may facilitate the emergence and dissemination of zoonotic microsporidian lineages. Integrating marine Microsporidia into One Health surveillance frameworks is therefore increasingly important for both ecosystem and public health management.
- Derleme MakaleAçık Erişim2026Quaternary palaeoenvironmental archives of the Indian subcontinent and their imprint on herpetofaunal biogeography: A multi-proxy synthesis
Kurnaz, Muammer
This review presents the first integrated proxy, mechanism and biotic-response framework for the Indian Quaternary, linking the Subcontinent's dense network of palaeoenvironmental archives to the biogeographic trajectory of its endemic herpetofauna. Speleothem δ18O records, Arabian Sea and Bay of Bengal sediment cores, Karewa and peninsular lake sequences, Siwalik and Narmada alluvium, and Kurnool cave deposits together document Indian Summer Monsoon (ISM) variability on orbital, millennial, centennial and historical timescales (the historical band here denoting the past ∼2000 years, resolved by dated speleothem and documentary records). Against this proxy backbone, the fossil and molecular phylogeographic record of Indian amphibians and reptiles is evaluated as a biogenic assemblage here, the body of biological evidence (fossils, subfossils and the phylogeographic signatures of living taxa) that, like pollen or foraminifera, records past environmental conditions that complements geological and climatological archives. Three patterns emerge. At orbital scale, ISM variability aligns with Plio–Pleistocene diversification slowdowns in Western Ghats ranoids and with the Late Pliocene lineage divergence of the Himalayan toad Duttaphrynus himalayanus across the Thakkhola basin. Abrupt Holocene excursions, including the 8.2 ka and 4.2 ka events, are resolved at high precision in speleothem and marine archives but remain untested against coalescent demographic inference in Indian herpetofauna. Late Pleistocene aridity, most severe at the Last Glacial Maximum, coincides with community-level impoverishment in peninsular cave faunas at Kurnool, although the available evidence establishes co-occurrence rather than a demonstrated causal role for aridity relative to co-varying thermal and vegetation change. Three proxy-calibrated research priorities follow: microvertebrate taphonomy in Narmada and Karewa sequences, population genomics tied to speleothem chronology, and species-distribution hindcasting to the LGM, mid-Holocene and 4.2 ka intervals. The synthesis contributes to a biogenic assessment of Quaternary-to-Recent climate impacts on life on the Indian Subcontinent, aligned with UN Sustainable Development Goals 13 (Climate Action) and 15 (Life on Land), and supports future projections of amphibian and reptile response to ongoing change.
- Derleme MakaleAçık Erişim2026Intersection of Precision Nutrition and Bladder Cancer: A Narrative State-of-the-Art Review of Potential Applications and Challenges
Koçak, Tevfik; Özbek, Yağmur Demirel; Bodur, Mahmut; Yeşil, Süleyman; Ağagündüz, Duygu
Bladder cancer (BC) is a biologically heterogeneous tumor affected by genetic, metabolic, environmental, and lifestyle factors. Recent research indicates that nutrition can change the way urothelial cancer forms by affecting inflammation, oxidative stress, cellular energy, and the epigenome. It can also change the risk of BC and how well treatment works. Simultaneous progress in precision nutrition (PN) and nutriomic profiling—encompassing nutrigenomics, nutrigenetics, nutriepigenetics, metabolomics, and microbiome science—presents novel options to tailor dietary regimens beyond universal guidelines. In this review, we consolidate existing knowledge regarding the nutritional factors influencing BC, outline pertinent principles of PN for BC prevention and survival, and explore how urine proteomics and molecular subtyping facilitate the integration of PN into precision oncology. Our review examines the methodological, bioinformatic, biomarker, and clinical translation challenges that impede the implementation of PN in BC management; these challenges include the need for validated nutritional biomarkers with mechanistic endpoints, interoperable data platforms, and rigorously designed clinical trials. Finally, we emphasize future prospects for PN-guided medical nutrition therapy and dietary models during and after systemic treatment recovery. We propose research priorities that will facilitate the integration of PN-informed individualized dietary plans with medical and surgical approaches in BC treatment, aiming to decrease the costs associated with expensive or excessively aggressive treatment methods, thereby supporting long-term survival care. This review seeks to establish a conceptual framework for the integration of PN into BC management by delineating the opportunities and challenges, hence promoting hypothesis-driven research in a promising yet underexplored domain.
- Derleme MakaleYalnız künye2026Activated Carbon Derived from Coal and its Application for Wastewater Treatment
Daulay, Amru; Yassaroh, Yassaroh; Huda, Miftahul; Sumardi, Slamet; Prasetia, Hendra; Kumaş, Cavit; Yusmiati; Lestari, Devi
Coal is used to produce fuels, chemicals, and other high-value-added products to improve efficiency. Activated carbon (AC) derived from coal is an important part of coal’s resource utilization and is high-value-added. This study presents relevant research on AC derived from coal, including raw material selection, preparation methods, modification techniques, and regeneration methods. The potential applications of AC derived from coal for the adsorption of contaminants, including heavy metals, pesticides, pharmaceutical compounds, and organic and inorganic compounds, are reviewed. One of the advantages of using AC derived from coal in wastewater treatment is high adsorption, low cost, and sustainability.
- Derleme MakaleAçık Erişim2026Postbiotics in Dairy: A Comprehensive Review of Applications and Health Impacts
Kaya, Yasemin; Aktaş, Haktan; Meral-Aktaş, Hacer; Ürkek, Bayram; Gürbüz-Kaçan, Zeynep; Çiftçi, Esengül; Erkaya-Kotan, Tuba; Şengül, Mustafa; Çetin, Bülent
Purpose of Review: This review aims to provide a comprehensive overview of postbiotics—defined as non-viable microbial cells, cell components, and microbial metabolites—and their emerging role in dairy products. It focuses on their functional, technological, and health-promoting properties in various dairy matrices, including yoghurt, cheese, kefir, fermented milk, and ice cream. Additionally, the review highlights the potential of postbiotics as stable and safe alternatives to probiotics in the development of functional dairy foods. Recent Findings: Recent evidence demonstrates that postbiotics such as exopolysaccharides (EPS), bacteriocins, short-chain fatty acids (SCFAs), bioactive peptides, and organic acids significantly enhance both the nutritional value and technological quality of dairy products. These compounds have been shown to improve texture, sensory attributes, shelf life, and microbial safety while exerting biological activities, including antimicrobial, antioxidant, immunomodulatory, and gut health–promoting effects. Compared with probiotics, postbiotics offer greater stability during processing and storage as well as reduced safety concerns, particularly for vulnerable populations. Summary: Postbiotics represent a promising strategy for advancing functional and sustainable dairy products by combining health benefits with technological improvements. Their applications in functional food formulation, biopreservation, and bioactive compound delivery are rapidly expanding. However, challenges remain regarding standardised production processes, accurate quantification of bioactive components, and clinical validation of health claims. Future research should focus on optimising postbiotic production and strengthening evidence for their physiological effects to support their broader incorporation into next-generation dairy products.
- Derleme MakaleYalnız künye2026A systematic review of studies evaluating immersive virtual reality applications to support nursing education for nursing students
Aydin, Aydanur; Güler, Sevil; Bulut, Hülya
Objectives: Virtual reality (VR)-based interventions are widely used in education. However, it is necessary to systematically examine the outcomes of immersive virtual reality (IVR) applications in nursing education, clarifying their impact on knowledge, skills, and attitudes among nursing students. Methods: This review utilized the methodological framework of the Joanna Briggs Institute. A search was conducted of the Ovid MEDLINE, PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Web of Science, and Scopus databases for the period from 2013 to 2023. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) protocol informed the review and screening of the literature. The articles were assessed for eligibility via first screening by abstract review, followed by a full-text review. The first two authors reviewed the articles, assessing qualification for inclusion and evaluating the content. Data from eligible articles were analyzed and synthesized to answer the research question. Results: Of the initial 667 articles, 11 articles met the inclusion criteria for final analysis. The findings indicate that IVR applications in clinical practice positively impact nursing students, as IVR provides effective results in increasing their knowledge. Nursing educators should avoid comparing the results of students’ IVR practice with classical clinical practice. Nursing students should continue to engage in clinical practice, as it remains an essential aspect of their education. While technological applications such as IVR may be useful, they should not be used as a substitute for clinical practice. This review highlights the reported outcomes and benefits of clinical teaching methods in nursing. Conclusion: A limited number of articles were found that evaluated the education of nursing students in IVR applications. The analyzed articles found that nurse educators experienced meaningful knowledge exchange with students after IVR implementation. Further research is needed to identify effective outcomes in clinical education. It is essential to advance science to transform clinical education and use it more consciously to teach practical thinking and decision-making about patient care.
- Derleme MakaleYalnız künye2026Sustainable Mining: Environmental Challenges, Mine Tailings Management and Technological Innovations
Orak, Mürsel
Mining provides essential raw materials for global economic development; however, it is also associated with significant environmental impacts including land degradation, water contamination, and the generation of large volumes of mine tailings. Sustainable mining has emerged as a strategic framework aimed at balancing economic benefits with environmental protection and social responsibility. This study presents a comprehensive review of sustainable mining practices with particular emphasis on environmental impacts, mine tailings management strategies, acid mine drainage mitigation, and innovative technologies such as cemented paste backfill (CPB). In addition, the role of circular economy approaches, digital mining technologies, and mine closure strategies in improving sustainability performance is discussed. The findings indicate that integrating advanced tailings management strategies and technological innovations can significantly reduce environmental risks and enhance the long-term sustainability of mining operations.
- Derleme MakaleYalnız künye2026A review study of recent advancements in polymer heat exchanger technology in the aspect of heat transfer
Celen, Ali; Budak, Selahattin; Celen, Pınar; Dalkılıç, Ahmet Selim
Many applications use metallic heat exchangers, but some operating conditions, such as desalination, exhibit wear and corrosion problems. Thus, it is important to develop and use alternative materials to metals for such conditions. Although polymers have low thermal conductivity, corrosion resistance, cost-effectiveness, and lightweight, polymer heat exchangers can be constructed to overcome this problem. They were introduced in the last decades; advancements in 3D printing technology help manufacture complex, novel, and thin heat transfer surfaces. Although review studies are limited, recent research has not explored heat transfer-based reviews of heat exchangers produced by additive manufacturing and polymer hollow fibre methods. In this study, polymer heat exchanger works were reviewed and classified according to tube diameter as polymer and polymeric hollow fibre heat exchangers as the most updated ones. Generally, the studies focused on the thermal performance of heat exchangers constructed with metal and polymer materials, and the results were compared to determine the usability of polymer-based ones. As a result, polymeric hollow fibre heat exchangers may compete with metallic ones due to low wall resistance and enhanced heat transfer surface area because of the development of manufacturing technology. Also, the cost and weight of polymeric hollow fibre exchangers are lower, and they can be operated under corrosive conditions. Finally, it is obvious that increased research is needed to enhance the properties of polymer materials to increase the performance of this type of heat exchanger.
- Derleme MakaleYalnız künye2026Immunosuppressant adherence levels in kidney transplant recipients measured by electronic monitoring devices: A systematic review and meta-analysis
Tuncer, Metin; Yalcinkaya, Turgay; Erol, Ahmet; Özalp, Cemal
Background: Kidney transplantation improves survival and quality of life in patients with end-stage renal disease; however, long-term graft success depends on adherence to immunosuppressive therapy. Objective: To quantify adherence levels among kidney transplant recipients using electronic monitoring devices. Methods: PubMed, Web of Science, Scopus, and the Cochrane Library were systematically searched for studies published between 2000 and 2025. A random-effects meta-analysis was conducted including studies that assessed adherence using electronic monitoring devices. Results: Seven studies with a total of 1025 kidney transplant recipients were included. The pooled mean adherence measured using electronic monitoring devices was 94.39%. In studies with monitoring durations of three months or longer, adherence decreased to 90.50%. Substantial heterogeneity was observed across studies. Conclusion: Although electronically measured adherence appears generally high, its decline over longer monitoring periods indicates that adherence is dynamic and may decrease over time. However, these estimates should be interpreted cautiously because electronic monitoring devices cannot confirm actual medication ingestion. Furthermore, intentionally non-adherent patients may be less likely to participate in or remain engaged with electronic monitoring studies and may therefore be underrepresented, potentially leading to an overestimation of true adherence. Even modest reductions in adherence may carry important clinical consequences, underscoring the need for sustained monitoring.
- Derleme MakaleAçık Erişim2026Artificial-intelligence–based developmental screening for pre-school children (ages 3–6): a scoping review of deployed tools, clinical validity, equity, and implementation in guidance-center settings
Arslan, Adem; Gül, Fatih
Background – Early identification of neurodevelopmental conditions during the pre-school years (ages 3–6) is critical for timely intervention, yet traditional questionnaire-based screeners suffer from low positive predictive value, late detection, and inequitable access. Artificial intelligence (AI) and machine-learning (ML) methods promise more objective, scalable identification, and two devices (Cognoa Canvas Dx, 2021; EarliPoint Evaluation, 2023) are already US Food and Drug Administration (FDA)-authorized. Recent reviews summarize the technical literature, but few address how deployed tools perform on clinical validity, equity, and real-world implementation, particularly outside high-income, English-speaking settings. Methods – Following Joanna Briggs Institute methodology and the PRISMA extension for scoping reviews (PRISMA-ScR), we searched seven databases (1 January 2020–15 June 2026) and charted primary validation studies of AI/ML developmental-screening tools for children aged 72 months or younger. We mapped tools by modality, diagnostic performance, regulatory status, geographic origin, and, as a structured analytic axis, demographic subgroup (equity) reporting and deployment readiness. Results – Sixteen primary AI-tool studies met inclusion, spanning eight modality classes (eye-tracking, multimodal questionnaire-plus-video, computer-vision home/clinical video, tablet/smartphone digital phenotyping, voice/acoustic ML, electronic-health-record risk prediction, questionnaire-based ML, and wearable sensors) and eight countries (USA, South Korea, Australia, Switzerland, France, Israel, China, Vietnam). Reported sensitivities ranged from approximately 75 to 99.2% and specificities from 78.9 to 95.5%. Only one tool demonstrated stable performance across sex, race, and ethnicity; subgroup-stratified validation was otherwise near-absent. No CE-marked autism-specific screening device was identified. Conclusions – The evidence base has broadened in modality and geography but remains autism-concentrated and equity-blind, with a wide gap between analytic accuracy and primary-care deployment. We propose equity validation, deployment-readiness reporting, and an implementation pathway for low-resource guidance-center settings as priorities.
- Derleme MakaleYalnız künye2026A systematic and evolutionary analysis of software design pattern detection and recommendation approaches (2015–2025)
Turk, Salih; Coskuncay, Ahmet
Context: Automated detection and recommendation of software design patterns is crucial for software maintenance, reverse engineering, and architectural quality. Despite decades of research, the field has undergone a significant transformation with the emergence of deep learning and large language models (LLMs), leading to a fragmented landscape of methodologies and evaluation settings. Objective: This study aims to provide a systematic and evolutionary synthesis of design pattern detection and recommendation approaches published between 2015 and 2025, categorizing them into distinct technological paradigms and identifying open research challenges. Method: Following Kitchenham’s evidence-based software engineering guidelines and PRISMA principles, a systematic literature review was conducted. We executed a structured search on the Web of Science database, identifying 212 initial records. After rigorous multi-stage screening and quality assessment, 66 primary studies were selected for final synthesis and analysis. Results: The evolution of the field is characterized through six distinct paradigms: Rule-Based, Graph-Based, Feature-Driven Machine Learning, Representation Learning (Deep Learning), Hybrid, and Contextual Intelligence (LLM). Findings reveal a clear methodological shift from structural exactness to semantic and contextual understanding. However, the analysis also identifies a high concentration on specific datasets (JHotDraw and P-MARt) and a lack of standardized benchmarks for variant detection and multi-modal analysis. Conclusions: While LLM-based approaches show promise in handling pattern variants and semantic context, the field requires more diverse benchmarks and explainable models. This review provides a comprehensive research roadmap, emphasizing the need for multi-modal frameworks and industry-scale validation to bridge the gap between academic research and practical software engineering.
- Derleme MakaleAçık Erişim2026Physiological responses and adaptive mechanisms of amphibians and reptiles to multiple interacting environmental stressors: an integrative review
Kurnaz, Muammer
This integrative review synthesizes current knowledge on the physiological responses and adaptive mechanisms of amphibians and reptiles to multiple interacting environmental stressors, with particular emphasis on synergistic effects among temperature, hydric stress, disease, and pollution. Given the stronger empirical basis for amphibians in the existing literature, amphibian responses are covered in greater depth, while reptile-specific physiology, immunology, and emerging infectious diseases are explicitly addressed in dedicated sections throughout the review. Critical thermal tolerance analyses reveal that approximately 7.5% of amphibian species will exceed their physiological limits under a 4 °C warming scenario, with tropical lowland species already operating near their CTmax thresholds. Thermal plasticity is limited, with acclimation responses averaging only 0.13 °C increase in CTmax per 1 °C environmental warming—insufficient to track rapid climate change. Water balance regulation shows dramatic interspecific variation, with cutaneous resistance ranging from 0.05 s/cm in aquatic amphibians to >1000 s/cm in desert-adapted reptiles. Synergistic interactions between thermal and hydric stress significantly amplify vulnerability, particularly in dehydration scenarios that reduce critical thermal limits. Chemical pollutants, including heavy metals and pesticides, cause developmental abnormalities (535% increase in malformation frequency), immunosuppression, and endocrine disruption across multiple life stages. Emerging infectious diseases, particularly chytridiomycosis (Batrachochytrium dendrobatidis and B. salamandrivorans) and ranaviruses, drive mass mortality events globally, with co-infections exacerbating population declines. Climate change intensifies disease susceptibility through stress-mediated immunosuppression and altered pathogen dynamics. Adaptive capacity varies markedly among species. While amphibians exhibit strong phenological responses (2-4× greater than other taxa), genetic adaptation potential remains limited by narrow dispersal abilities and habitat fragmentation. Microhabitat buffering can reduce thermal extremes by several degrees but depends critically on habitat structural integrity. This review demonstrates that the pace of anthropogenic change challenges the adaptive capacity of most species, necessitating integrated conservation strategies including microhabitat preservation, climate corridor establishment, pollution mitigation, disease surveillance, and ex-situ conservation programs.
- Derleme MakaleYalnız künye2026Red mud as a source of scandium: A review
Kumaş, Cavit; Prasetia, Hendra; Astuti, Widi; Sumardi, Slamet; Mufakhir, Fika Rofiek; Fasya, Muhammad Rizki Firdaus
The residue produced during the extraction of aluminum from bauxite ore via the Bayer process is known as red mud (RM), with 0.5–2.5 t of RM generated for each ton of alumina produced. Due to its highly alkaline nature (pH = 10.0–12.5), RM poses significant environmental threats and requires large storage areas. To address this environmental concern and develop sustainable way to utilize RM, extensive research has been conducted in fields such as soil remediation, metal recovery, steel production, catalytic reactions, cheap adsorbents for pollutant removal, ceramics, brick production, and pigment and slag additives for paint production. While early studies on metal recovery from RM focused on the recovery of metals such as Fe and Al, recent years have seen an increase in research on Sc recovery from RM, as RM is now recognized as an important source for Sc. This review examines in detail methods such as direct acid leaching, bioleaching, acid baking, and water leaching used for Sc recovery from RM. Additionally, data on the recovery of not only Sc but also other metals from RM are presented.
- Derleme MakaleYalnız künye2026Virtual reality as a non-pharmacological adjuvant for anxiety in oncology care: a systematic review and meta-analysis
Aydin, Aydanur; Bağcivan, Gülcan; Özkan, Aleyna
Background: Despite its growing presence in healthcare settings, research on the effectiveness of virtual reality (VR) interventions for symptom experience of patients with cancer remains varied and requires a comprehensive synthesis to reach definitive conclusions. Objective: This systematic review and meta-analysis aimed to assess the effectiveness of VR interventions in managing anxiety among individuals diagnosed with cancer. Methods: A comprehensive search of Ovid MEDLINE, PubMed, CINAHL, Web of Science, and Scopus databases was conducted for studies published from 2000 to November 2025. Publications were evaluated by independent reviewers for inclusion. The methodological quality of the included studies was assessed via Joanna Briggs Institute (JBI) critical appraisal tools for randomized controlled trials and quasi-experimental studies. Results: Twenty-one publications satisfied the requirements for review inclusion. The meta-analysis demonstrated that VR-based interventions were significantly effective in the management of patients’ anxiety, yielding a moderate-to-high effect size (SMD = −0.793, 95% CI = −1.403 to −0.184; Z = −2.551; p = 0.011). Most studies reported statistically significant decreases in anxiety scores across various cancer types, including breast, prostate, and ovarian cancers. No major side effects were reported, although minor instances of cyber sickness were managed by adjusting session durations. User satisfaction was exceptionally high, with satisfaction scores reaching 4.47/5 and 7.35/10. Implications for practice: The results support the use of VR as an effective and safe non-pharmacological intervention for anxiety management. The findings highlight the potential for VR to be integrated into routine oncology nursing and palliative care to improve the patient experience during stressful treatments like chemotherapy. Conclusion: VR-based interventions are an effective, safe, and highly acceptable approach for managing anxiety in patients with cancer. Further research is needed to support wider clinical implementation and to investigate the potential benefits of VR for other physical and psychological symptoms over longer follow-up periods. Trial registration: PROSPERO International Prospective Register of Systematic Reviews CRD42022351573.