Gümüşhane ÜniversitesiGümüşhane ÜniversitesiAçık Erişim Arşivi · RDL Open

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  • MakaleYalnız künye2013
    Critical approaches to modern public sphere: a general evaluation (postmodernism, feminism and religion)

    Koroglu, Cemile Zehra

    The modern concept of the public sphere is expressed via the understanding of the public sphere which emerged after the 18th century. In this sense, it is possible to mention many debates regarding the public sphere which suggest different models. However, in our study within the framework of Hebermas, it has followed that the common principles and ideas of the modern public sphere have critical approaches previously unexplored. The principles of the modern publicsphere are determined within the framework of understanding man, universe, and society as determined by the idea of enlightenment. Since the modern public sphere is considered as a sphere for political purposes, it also has roots in the legitimacy of modern politicaland legal systems. Therefore, a concensus on the political issues being discussed in the public sphere. To reach definitive conclusions and conduct public negotiations correctly, it has been determined the basic principles of participants must be individuals with a rational mind. Beginning with the universality of mind, the universality of the public sphere is targeted. Modern public sphereres present universal values in which an exclusive and unequal character for many social groups which do not have these principles and values. Therefore, discussion and criticisms of the public sphere in the modern era have always been on the agenda. In addition to individual criticisms, different criticisims of a variety of philosophical and social movements on modern public sphere can be mentioned. However, criticisms from the perspective of postmodern feminism and religion are important as they are criticisms for the foundation of the public sphere. Although these three approaches are verydifferent from each other, they share similar points of criticism and even provide legitimacy for each other. Although religion and postmodernism criticizes the understanding of the enlightened and rational mind, the human universe, and secularity, feminism criticizes the determination of modern public spheres by men. Each perspective regarding criticism and legitimacy are different; however, the roads can cross on the critique of the modern public sphere

    AtıfTR Dizin9
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  • MakaleYalnız künye2013
    The relationship of ethics-politics in max weber’s works

    Doğan, Kadir Caner; Yilmaz, Nihat

    One of the most important problems of current societies is the problem of ethics. It is not easy to solve this ethics problem in societies where it is not considered in terms of certain moral concerns orconcerns about moral problems are not seriously considered. If the problem of ethics is present in a societal system or, more importantly, in a rulership which has the monopoly of using legitimate powers, more serious problems can be faced. Undoubtedly, the most effective tool for politicians to avoid unethic behavior or overcoming corruption in a general sense is political ethics. In the sense of politic ethics, Max Weber’s work “Politics as a Vocation” in the year 1919 where in Weber made ethic classification and explanations on political function of ethics is an important work which should especially be read by current politicians and still keeps its currency. As a matter of fact, in this declaration, the foundation is, firstly, how Weber defines the concept of “ethics”, and how the relationship between ethics and politics is established according to Weber. Information is provided as to how political newcomers should be acting, and in this sense, the duo of “ethics of belief” and “ethics of responsibility”, which holds an important place on how explanation of the relationship between ethics and politics, is touched upon.

    AtıfTR Dizin2
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  • MakaleYalnız künye2013
    The psychological analysis of religious conversion in muhammad asad

    Kartopu, Saffet

    At this work on Which religious conversion in Muhammad Asad is studied, in terms of religious conversion models, first of all the concept of religious conversion, the Works in this topic and the place of religious conversion concept in Psychology of Religion are mentioned. Then, a brief life story of Asad is mentioned, by dealing with the religious conversion in Asad in a theoretical approach, the motives of religious conversion, the developmental factors in religious conversion, the stages of religious conversion and the figures of religious conversion are studied. The religious conversion in Asad is analyzed in terms of conversion models accepted in Psychology of Religion taking his own Works as a base. In this sence, while the motives of religious conversion in Asad are considered by the approaches of Snow & Phillips, Glock and Gillespie, the developmental factors in religious conversion are considered by Erikson’s thoughts. The stages of religious conversion is considered by gradual classification of Lofland & Stark, Clark, Batson & Ventis and Köse. Lofland and Skonovd’s types are used while analyzing the figures of conversion. When considered the effects of psychological factors on the religious conversion of Asad, we see that beginning from his early adolescence his willing to understanding and his need to mental satisfaction are explicit. Asad is in need of reviewing the main points imposed by his cultere. He is disturbed by the ambiguities in society and his own life and he looks for answers to the universal meaning of life and questions ‘what is right? what is wrong?’. As a result of his seeking, he accepts Islam as his religion and he gains a feeling of belonging, admission and a change of rearranging himself radically. By accepting Islam he feels that all his seekings finish and his desire of depending on a certain intellectua orbit and being a part of fellows community come true

    AtıfTR Dizin1
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  • MakaleYalnız künye2013
    Yumurta tavuğu rasyonlarına katılan kanola yağı ve vitamin c'nin performans, yumurta kalitesi ve lipid peroksidasyonu üzerine etkisi

    Kılınç, Gözde; Karaoğlu, Mevlüt

    Bu çal ışma Atatürk Üniversitesi Ziraat Fakültesi Ara ştırma ve Uygulama Çiftliğ inde yumurta tavu ğu rasyonlarına kanolayağı ve vitamin C ilavesinin performans, yumurta kalitesi ve yumurta sarısı TBARS de ğerleri üzerine etkilerini belirlemekamac ıyla yürütülmü ştür. Araştırmada, 40 haftalık ya şta toplam 72 adet Lohmann ırkı beyaz yumurtacı tavuk, her grupta 18 adetolacak şekilde biri kontrol, üçü deneme grubu olmak üzere toplam 4 gruba şansa ba ğlı olarak da ğıtılmıştır. Gruplar, her birinde 3hayvanın bulunduğ u 6 alt gruptan oluşturulmuştur. Kontrol grubu (I) bazal yemle, diğer gruplar ise bazal yeme %4 düzeyindekanola ya ğı (II), 200 mg\\kg vitamin C (III) ve %4 kanola ya ğı+200 mg\\kg vitamin C (IV) ilave edilen rasyonlarla 12 hafta boyuncabeslenmişlerdir. Deneme süresince yem ve su ad-libitum olarak verilmiştir. Rasyona vitamin C (III) ilavesinin yumurta veriminiartırmasının yanı sıra (P<0.05) yemden yararlanmay ı iyile ştirdiği (P<0.01); kanola ya ğının (II) yumurta a ğırlığını artırdığı(P<0.01); kanola ya ğı ve vitamin C kombinasyonunun (IV) ise günlük yem tüketimini önemli (P<0.01) düzeyde düşürdüğü tespitedilmi ştir. Ayrı ca kontrol grubuyla k ıyaslandığında, deneme gruplarında hasarlı yumurta oranını n azald ığı (P<0.01) belirlenmiştir.Kalite kriterlerinden sarı rengi ve sarı indeksi hariç yumurta a ğırl ığı, k ırılma mukavemeti (kg/cm2), şekil indeksi (%), kabukkalınlığı (mm), ak indeksi (%) ve Haugh birimi de ğerleri bakımından gruplar arasında herhangi bir farklılık meydana gelmemiştir.Rasyonda vitamin Cnin kullanı lması sarı rengi diğer gruplara göre önemli düzeyde (P<0.01) artırırken; kanola ya ğının tek ba şına(II) veya vitamin C ile kombine edildiğ i grupta (IV) ise sarı indeksinde artış (P<0.05) gözlenmi ştir. Vitamin C ilavesinin (III) 21gün süreyle depolanan yumurtalarda tiyobarbiturik asit reaktif madde (TBARS) de ğerini azalttığı (P<0.05); kezâ 42 gün süreyledepolanan yumurtalarda ise kanola ya ğı ilaveli gruba (II) göre TBARS de ğerini önemli (P<0.05) derecede dü şürdü ğü belirlenmiştir.Sonuç olarak, vitamin C ve kanola ya ğını n bazı performans ve kalite parametreleri üzerine olumlu etkide bulunduğu; doymamışya ğ asidi içeri ği fazla olan kanola ya ğı ile beraber vitamin Cnin rasyona katılmasıyla yumurtada lipid oksidasyonunun azaldığı veböylece raf ömrünü uzattığı tespit edilmiştir.

    TR Dizinİncele
  • MakaleYalnız künye2013
    Belediye Başkanlığı Aday İmajı Algısı: Gümüşhane Örneği

    Güllüpunar, Hasan

    Seçmen davranışları bakımından bireyselleşme ile birlikte yeni bir süreç başlamıştır. Bu süreçte oy verme davranışında ideoloji, parti bağlılığı gibi kavramlar etkisini eskiye göre kaybetmiştir. Yeni dönemde proje, hizmet, toplumsal ilişkiler, sivil toplumsallaşma içinde yer alma, yeterlilik gibi kavramlar ön plana çıkmıştır. Bu durum aday merkezli seçim kampanyalarının yaygınlaşmasına neden olmuştur. Özellikle yerel seçimler bağlamında düşünüldüğünde adaylar seçmenin iknası bakımından önemli bir etken olarak ortaya çıkmaktadır. Bu nedenle siyasal seçim kampanyalarının öncelikli hedeflerinden biri güçlü bir aday imajı oluşturmaktır. Ancak zaman, bölge, seçim atmosferi, seçmenlerin sosyodemografik özellikleri gibi birçok alt etkene sahip olan aday imajı algısı karmaşık bir yapıya sahiptir. Dolayısıyla toplam aday imajının çok sayıda alt bileşeni bulunmaktadır. Bu çalışma Gümüşhane seçmeninin aday imajı algısının tespitine dönük olarak yapılmıştır. Basit tesadüfi örneklem yöntemi ile toplam 747 kişiyle görüşülen ve doğrulayıcı faktör analizinin yapıldığı araştırmada aday imajı ile ilgili görsel, siyasal, konu, hitabet ve sosyal olmak üzere beş faktör ortaya konmuştur. Toplam aday imajına etki eden en önemli faktörün sosyal faktör olduğu görülen araştırmada diğer faktörler toplam imaj üzerindeki önem sırasına göre hitabet, konu, siyasal ve görsel faktörler olarak sonuçlanmıştır.

    AtıfTR Dizin7
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  • MakaleYalnız künye2013Scopus SJRQ3
    A PRACTICAL APPROACH FOR TREATMENT OF MUNICIPAL WASTEWATER BY ACTIVATED SLUDGE PROCESS

    Nas, S. S.

    This study deals with calculating reactor volumes using a graphical process in treatment of wastewaters by activated sludge process for discharge and carbonaceous biochemical oxygen demand (CBOD), different sludge ages, biomass concentrations, pollution loads and effluent soluble CBOD concentration. CBOD, measurements are carried out by using the standard oxidation (or incubation) test. Ultimate CBOD values are also estimated by the moment ad the least square methods. This study shows that the daily average pollution load of wastewaters is 352.5 kg d(-1) (monthly average discharge 20.4 1 s(-1), influent CBOD concentration 200 mg l(-1), activated sludge pond volume is 203-258 m(3) for different effluent CBOD concentration (50-40-30-20-10 mg l(-1) and biomass concentrations (3-3.5-4-4.5-5 g l(-1)) that are obtained from pollution loads volume charts. Therefore, data collection and the facility sizing are being illustrated by determining both quality quantity profile of a residential (KTU Central Campus) wastewater and the effect of the various parameters to the reactor.

    AtıfWoS1
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  • MakaleYalnız künye2013
    Social Construction in the Context of Being a Model of Hazrat Prophet in the Verses Descended in Madina

    Deliser, Bilal

    In this study it was processed that the Hazrat Prophet's revelation and the revelation's main principles, how they are set an example in all area of the life by discussing with general classification. Thus, the subject tried to be based in terms of epistemic perspective. This foundation, in the society where Hazrat Prophet lived, without granting to the case with all dimensions, is concrete models crossing the case revealing direction of revelation. These models consisting of believes about conviction, practical, moral, political and social virtues concretized himself in a position without diseppearing in the horizon of humanity. In this sense, the revolution, which Quran fulfilled, can be said that entirely happened through his close relatives. The word of construction which was mentioned in the title of the study was not used in the mean of construction of the absent, but it was used in the mean of developmentand reform, meeting some on ewith his creation in all areas. As method, verses consisting of concrete models were determined in the verses descended in Madina and classificated under some titles. About verses and groups of verses was given information just fore liminating obliqueness, it was not detailed. Int his way, it was searched finding possibilities of an approachto be foundation for interpreting and a rising point. Our study has not an aim of explaining the history of spreading Quran must be taken into consideration.

    Web of ScienceTR Dizinİncele
  • MakaleYalnız künye2013
    The Use of Framing Theory in Public Relations

    Güran, Mehmet Salih; Özarslan, Huseyin

    Although framing approach has been used practically so far mainly in the fields of political communication and journalism, in particular the development of public relations and new media has increased its practical potential for public relations practitioners. The aim of this paper is to review public relations and journalism research for the practical possibilities the framing approach presents to public relations in enhancing the effectiveness of news media usage.

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  • MakaleYalnız künye2013
    Do Exchange Rates and Budget Deficit Lead to Inflation? A Panel Causality Analysis on Developing Asian Countries

    Dogru, Bulent; Recepoglu, Mursit; Çelik, Orkun

    In developing economies, budget deficit and exchange rates can lead inflation through shallow financial markets. In this study it is tested whether budget deficit and exchange rates cause inflation in long-run and short-run for 22 developing Asian countries for the time period of 1980 and 2011. The reason why we select all the developing countries from one region is that we assume all countries have fixed unit effect in the models. In this study we use panel cointegration, error correction model and panel causality methods as empiric test. Findings suggest that in short-run there is no causality running from exchange rate and budget deficit to inflation but in long-run budget deficit and exchange rates cause inflation.

    AtıfTR Dizin4
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  • MakaleYalnız künye2013
    Suras Period And Adam (Pbuh)-Demons Parable

    Sahin, Davut

    Suras of the Qur'an are divided into two periods. These are Meccan and Medinian. It is known in two ways. 1. Rumors 2. Criteria. One of the criteria is as follows: Adam-demon stories are at the Meccan sura. However, it is outside Baqara. In our study, we will discuss this criterion. Which words in stories or issues are related to the Medinan period? Do you have a sign in the parable? According to the commentators, what is the relevance of the parable and the Medinan period? In this respect, al-Tabari and al-Razi's explanation will be examined. Two commentators considering the following description will be proposed: When determining the period of suras, information during the period of revelation should be heeded.

    AtıfTR Dizin1
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  • MakaleYalnız künye2013
    Source Value of Foreign Travel Books in Terms of Ottoman City Histories

    Yilmaz, Ozgur

    During the writing an Ottoman city history, travelogues have an important place among other sources that could be consulted. These books, their authors whether local or foreign, contain valuable information worth checking out carefully in many ways. Though different discussion on travel books about their value of historical source exists, they reflect lively description of time and place, cultural structure of the period and make us possible to look at history from a different aspect. In this context, travelogues, as a source of Ottoman city histories, gained more importance in terms of Ottoman historiography. This paper aims to make, after a general review of the studies on travel accounts in Turkey, a few observations in terms of source value of travel books in city historiography.

    AtıfWoS1
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  • MakaleYalnız künye2013Scopus SJRQ2
    Yield, Quality, and Other Characteristics of Selected Lines of Crested Wheatgrass

    Gul, Zeynep Dumlu; Yolcu, Halil; Tan, Mustafa; Serin, Yunus; Gul, Ismail

    A field experiment was conducted to evaluate yield, quality, and other characteristics in selected lines of crested wheatgrass (Agropyron cristatum L. Gaertn.) at Ataturk University Agriculture Faculty Research Farm under unirrigated conditions during 2006, 2007, 2008, 2009, 2010, and 2011 in Eastern Turkey. The research was established in 2006 as a randomized complete block with three replications. Lines AC1 (Reg. No. PL-12, PI 667083), AC2 (Reg. No. PL-13, PI 667084), AC23 (Reg. No. PL-14, PI 667085), AC29 (Reg. No. PL-15, PI 667086), AC37 (Reg. No. PL-16, PI 667087), AC39 (Reg. No. PL-17, PI 667088), AC65 (Reg. No. PL-18, PI 667089), AC66 (Reg. No. PL-19, PI 667090), AC83 (Reg. No. PL-20, PI 667091), AC107 (Reg. No. PL-21, PI 667092), AC113 (Reg. No. PL-22, PI 667093), AC121 (Reg. No. PL-23, PI 667094), AC125 (Reg. No. PL-24, PI 667095) and Tohum Islah population (Reg. No. PL-11, PI 667082) (control) were evaluated for dry matter yield (DMY), seed yield (SY), straw yield (SWY), crude protein content (CPC), crude protein yield (CPY), stem number, plant height, and fertile tiller ratio. Forage DMY and SY increased over the first 4 yr, but the yields decreased due to the aging of the crested wheatgrass stand in the subsequent year. There were significant differences for lines in all variables, except for SWY and CPC. Particularly, lines AC1, AC23, AC29, AC37, AC39, AC65, AC66, AC107, and AC121 in DMY; AC1, AC37, AC83, AC107, AC113, AC121, and AC125 in SY; and AC23, AC39, and AC113 in CPY showed significant improvement compared with the original parent material. The results of DMY, SY, and CPY show that selection studies were effective. Selected lines will be useful for breeding studies and livestock production.

    • SDG 2 · Açlığa Son
    AtıfWoS3OpenAlex4
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  • MakaleAçık Erişim2013Scopus SJRQ2
    The prevalence of chronic bronchitis in adults living in the center of Gumushane

    Tutar, Nuri; Yesilkaya, Selma; Memetoglu, Mehmet Erdem; Özel, Deniz; Bosnak, Emre

    Introduction: Chronic bronchitis and emphysema are major components of chronic obstructive pulmonary diseases (COPD). The aim of this study was to determine the prevalence of chronic bronchitis 20 years and over living in the center of Gumushane and to analyze the risk factors. Materials and Methods: The study is targeted to reach 373 people who represent the center of Gumushane, 368 (98.6%) people have been reached. Participants were filled modified version of the questionnaire created by the Medical Research Council by face-to-face interview technique. Results: The prevalence of chronic bronchitis was 14.1%. The average age was in the chronic bronchitis group and nonchronic bronchitis group was respectively 43.2 +/- 12.9, 39.3 +/- 11.6, and the differance was statistically significant (p<0.05). Considering the relationship between cigarette smoking with chronic bronchitis, it was more frequent in smokers than nonsmokers (p<0.001, OR 4.74, 95% CI 2.47-9.17). Chronic bronchitis was observed in passive smokers than in non-smokers (p=0.004, OR 2.86, 95% CI 1.36-6.03). Occupational exposure to dust, fumes and history of childhood pulmonary diseases were increased chronic bronchitis prevalence (respectively, p<0.001, OR 9.53, 95% CI 4.56-19.94; p<0.001, OR 12.14, 95% CI 5.87-25.12). Male gender, low income level and to warm up with stove were found statistically significant by univariate logistic regression analysis but these risk factors were not statistically significant in the multivariate analysis. Educational level was not found statistically significant in both analysis (p>0.05). Conclusion: The prevalence of chronic bronchitis was 14.1% in 20 years and older adults living in the center of Gumushane. Old age (especially over the age of 50), active or passive smoking, occupational history of dust, fumes and history of childhood pulmonary diseases were found to be risk factors for chronic bronchitis.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfWoS3OpenAlex2
    Web of SciencePubMedİncele
  • MakaleYalnız künye2013Scopus SJRQ3
    A rare cause of acute respiratory failure: spontaneous pneumomediastinum due to cocaine use

    Memetoglu, Mehmet Erdem; Kalkan, Asim; Tutar, Nuri; Kurtcan, Serpil; Gündüz, Abdulkadir

    Spontaneous pneumomediastinum is defined as free air in mediastinum without any underlying pulmonary pathology. Although spontaneous pneumomediastinum is a rarely seen clinical entity, it is one of the most common reasons of sudden pleuritic chest pain in healthy young individuals. Cocaine inhalation is also associated with the development of spontaneous pneumomediastinum. Our case having spontaneous pneumomediastinum was referred to our emergency service with the complaint of acute respiratory failure due to cocaine abuse, and the etiology, clinical presentation and the treatment of the disease were evaluated in our study.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfWoS2OpenAlex4
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  • MakaleYalnız künye2013Scopus SJRQ3
    The Anesthetic Effects of Clove Oil and 2-Phenoxyethanol on Rainbow Trout (Oncorhynchus mykiss) at Different Concentrations and Temperatures

    Yildiz, M.; Kayim, M.; Akin, S.

    In this study, anesthetic effects of five different concentrations of 2-phenoxyethanol (0.2, 0.3, 0.4, 0.5 and 0.6 ml/L) and clove oil (0.50, 0.75, 1.00, 1.25 and 1.50 ml/L) on rainbow trout (Oncorhynchus mykiss) were studied at temperatures 7, 13 and 18 degrees C. For this purpose, 900 fish (39.08 +/- 1.13 g and 15.48 +/- 0.21 cm) were used in the experiment. Induction time of 2-phenoxyethanol and clove oil varied between 1.05 and 3.36 min at all concentrations, except for 0.2 ml/L (for 2-phenoxyethanol only) and at every temperature application. Full recovery time occurred between 2.44 and 7.14 min for 2-phenoxyethanol and 3.23 - 6.11 min for clove oil. It was found that full recovery times significantly increased with increase in 2-phenoxyethanol concentrations (r(2)=0.81). The same increasing trend was observed in clove oil, but the increase was not strong compared to 2-phenoxyethanol (r(2)=0.21). On the other hand, full induction times of 2-Phenoxyethanol and clove oil significantly declined with the increase in concentrations (r(2)=0.74; r(2)=0.84 for 2-phenoxyethanol and clove oil, respectively). Based on the ideal induction (less than 3 min) and recovery (less than 5 min) time criteria, it can be suggested that the most appropriate concentrations for rainbow trout were 0.3, 0.4 and 0.5 ml/L for 2-phenoxyethanol and 0.50, 0.75 and 1.00 ml/L for clove oil.

    AtıfWoS16
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  • MakaleYalnız künye2013Scopus SJRQ3
    The Effect of Kefir Consumption on Human Immune System: A Cytokine Study

    Adiloglu, Ali Kudret; Gönülates, Nurettin; Isler, Mehmet; Senol, Altug

    The systemic effects of bioactive peptides which are produced by the fermentation of milk via the microorganisms found in kefir have been the subject of interest in recent years. Bioactive peptides activate innate immunity by stimulating macrophages, increasing phagocytosis, augmenting NO and cytokine production and boosting the lumen levels of IgG and 19A(+) B-lymphocytes. The aim of the present study was to determine the serum cytokine profiles of healthy volunteers after kefir consumption to evaluate helper T (TH) cell polarization and to bring out the effects on native and allergic immune responses. The study was designed as a prospective and self-controlled study. A total of 18 healthy volunteers (age range: 20-40 yrs, mean age: 35.5 +/- 7.38 yrs) from a university hospital staff were recruited to the study, with the approval of ethical board and informed consent. The body mass indices of all participants were between normal range (20.10-25.70 kg/m(2)). After two weeks of a diet free from fermented products, the participants consumed 200 mL kefir daily, for six weeks. Kefir product was prepared by using kefir starter culture (Danisco Biolacta Sp - 05223B 10001, Poland) which contains Lactobacillus spp., Leuconostoc spp., Lactococcus lactis ssp. lactis and Streptococcus termophilus, an overnight incubation at 26 C, and consumed freshly. Fasting blood samples of subjects were collected just before kefir use (0th week), at the end of the 3rd and 6th weeks of kefir consumption, and three weeks after cessation of kefir usage (9th week). Serum TNF-alpha, IL-1, IL-5, IL-8 and TGF-beta levels were measured by using commercial ELISA kits (BioSource, Belgium and Invitrogen, USA). Hemoglobin, serum creatinine and ALT levels of all subjects were also determined for follow-up. All volunteers completed the study period without any problem and declared no complaint. Hemoglobin, creatinine and ALT levels did not change with kefir consumption. Serum IL-8 levels were decreased at 3rd and 6th weeks (p<0.001) and were at low levels at 9th week (p=0.005) when compared with baseline levels (0th week). Serum IL-5 levels were increased at 3rd week (0th-3rd weeks; p=0.01) and decreased by a rebound effect at 9th (6th-9th week p=0.003). TNF-alpha levels were increased with kefir consumption (p=0.046) but the increase was insignificant in paired comparisons and the level was borderline between 0th and 6th weeks (p=0.013). IL-5 and TNF-alpha levels returned to their original levels (0th week) at 9th week. Levels of the other cytokines (IL-1 and TGF-beta) did not change significantly with kefir usage. These results indicated that kefir use increased polarization of the immune response towards TH, type and decreased TH, type response and accordingly allergic response. The decrease in IL-8 level due to kefir use, might control the inflammatory response by suppressing neutrophil chemotaxis and activation. On the other hand it was also concluded that increased IL-5 might stimulate secretory IgA at gastrointestinal mucosa leading to a more efficient immune response in the intestinal lumen.

    AtıfWoS29
    Web of SciencePubMedİncele
  • MakaleAçık Erişim2013Scopus SJRQ4
    Sequence Variant in the LPIN1 gene in Patients with Metabolic Syndrome

    Kural, Birgul Vanizor; Deger, Orhan; Erem, Cihangir; Yücesan, Fulya Balaban; Barlak, Yasam; Turan, Ibrahim; Aliyazicioglu, Rezzan

    Objective: Metabolic syndrome (MetS) is a complex disease characterized by insulin resistance, abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia and low HDL-cholesterol level. The aim of the study was to evaluate the sequence variations in the LPIN1 gene in MetS. This gene codes lipin-1 protein which functions as Mg-dependent phosphatidic phosphatase enzyme and transcriptional coactivator. Material and Methods: The study groups included 73 MetS (19 M/54 F) and 56 non-MetS (16 M/40 F). Sequence variation in exons 2, 4, 5 and 14 of the LPIN1 gene were investigated by DNA sequencing method. Results: c.696 G>C variant (p.S232S) in exon 5 was observed in only one women with MetS. But this variation is not important because of coding same amino acid. Conclusion: Any important sequence variant was not detected in exons 2, 4, 5 and 14 in the LPIN1 gene in MetS.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfWoS2OpenAlex2TR Dizin1
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  • MakaleAçık Erişim2013
    Evaluation of cardiovascular risk factors among university students in Turkey: a cross-sectional survey

    Kutlu, Rasim; Memetoglu, Mehmet Erdem

    Background - Recent data indicate increasing rates of mortality from cardiovascular (CV) disease in Turkey. This study aimed to evaluate CV disease risk factors among university students in Northern Turkey. Methods - In this cross sectional descriptive study, 302 students were randomly recruited (171 females (57%) and 131 males (43%), mean age of 20 +/- 2.1 years). Blood glucose, cholesterol profile (total, high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterols), triglyceride, glycosylated haemoglobin, resting blood pressure, and body mass index were measured using standard protocols. All participants were asked to complete a questionnaire including questions on lifestyle, genetic predisposition, smoking habit, and psychosocial factors. Results - The mean systolic and diastolic blood pressure of students were 127.1 +/- 13.5 mmHg and 78.3 +/- 12.4 mmHg. The mean values were 98.4 +/- 14.2 mg/dL for fasting blood glucose value, 5.4 +/- 0.4 for HbA(1c), 80.0 +/- 10.3 beats/min for heart rate, for total cholesterol 199.1 +/- 24.6 mg/dL, 43.8 +/- 9.9 mg/dL for HDL, 114.7 +/- 24.1 mg/dL for LDL, 199.1 +/- 24.6 mg/dL for trygliceride, 24.8 +/- 3.6 kg/m(2) for body mass index, 97.6 +/- 17.9 cm for waist circumference. No significant difference was observed between gender according to CV risk factors' values statistically. It was observed that 111 (36.8%) students were overweight, 32 (10.6%) were obes. About 135 (44.0%) of students had abnormally unacceptable WC value. Smoking habit was seen in 130 (43.0%) students [73 (24.2%) male and 57 (18.9%) female]. Conclusion - A substantial proportion of Turkish students were overweight or obese, and had smoking habit. Our results underscore the need to implement health promotion programmes and perform large-scale epidemiological studies within the general Turkish young adult population.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfWoS5OpenAlex12
    Web of Scienceİncele
  • MakaleYalnız künye2013Scopus SJRQ2
    Coronary Flow Reserve and Myocardial Performance Index in Newly Diagnosed Diabetic Patients

    Kalkan, Gulhan Yuksel; Gür, Mustafa; Sahin, Durmus Yildiray; Baykan, Ahmet Oytun; Elbasan, Zafer; Kuloglu, Osman; Kivrak, Ali; Türkoglu, Caner; Arik, Osman Ziya; Çayli, Murat

    BackgroundPatients with diabetes mellitus (DM) are at high risk of left ventricular (LV) dysfunction. A reduction of coronary flow reserve (CFR) has been demonstrated in diabetic patients without coronary artery stenosis. In this study, we investigated the association between LV myocardial diastolic and systolic functions and the CFR in newly diagnosed diabetic patients in the absence of coronary artery disease. MethodWe studied 88 patients (mean age 4910years) with newly diagnosed DM and 40 healthy control subjects (mean age 509years). All subjects underwent transthoracic echocardiography. The myocardial performance index (MPI) was determined by using pulsed-wave Doppler. The CFR was calculated as the hyperemic to resting coronary diastolic peak velocities ratio. ResultsPatients with diabetes had significantly longer mitral E-wave deceleration time and higher MPI value than control group (P=0.023 and P<0.001, respectively). The mean CFR was lower in diabetic patients compared with controls (P=0.001). The MPI was significantly correlated with CFR (r=-0.371, P<0.001), LV ejection fraction (r=-0.274, P=0.018) E/A ratio (r=-0.244, P=0.024), and glycosylated hemoglobin (HbA1c) (r=0.476, P<0.001). Multivariate regression analysis showed that MPI was independently associated with CFR (=-0.292, P<0.0001) and HbA1c level (=0.372, P<0.0001). ConclusionsThe MPI was independently associated with CFR in newly diagnosed diabetic patients. The decrease in CFR may cause LV systolic and diastolic dysfunction in asymptomatic diabetic patients.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfWoS11OpenAlex10
    Web of SciencePubMedİncele
  • MakaleAçık Erişim2013Scopus SJRQ3
    Comparison of the safety and efficacy of ivabradine and nebivolol mono- and combination therapies in the treatment of stable angina pectoris patients with left ventricular dysfunction

    Kutlu, Rasim; Memetoglu, Mehmet Erdem; Muratalievic, Tolkun Murataliev

    We aimed to investigate the pharmacoeconomic efficacy of ivabradine and nebivolol in treatment of stable angina pectoris patients with left ventricular dysfunction prospectively. Pharmacoeconomic analysis was performed by using cost minimization analysis, and cost effectiveness analysis. After 6 months' treatment LVEF for the nebivolol group (17 patients, 50%) improved by (38 +/- 6.5) to (41 +/- 3.2), (p>0.05) and for the ivabradine group (17 patients, 50%) (37 +/- 5.4) to (41 +/- 2.3), (p>0.05), mean MET value in the nebivolol group increased from (3.7 +/- 1.2) to (5.5 +/- 1.6), (p>0.05), versus from (3.6 +/- 1.5) to (5.5 +/- 1.4), (p>0.05) in the ivabradine group, cost minimization analysis results showed a difference in the total cost of treatment was US$ 5288.7 in favor of nebivolol. The findings suggest that nebivolol is more cost-effective than ivabradine in the treatment of patients with left ventricular dysfunction.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfWoS2OpenAlex2
    Web of Scienceİncele