Sürdürülebilir Kalkınma Amaçları

Yazarlar

  • MakaleAçık Erişim2017Scopus SJRQ3
    A fourth order approximation of the neumann type overdetermined elliptic problem

    Ashyralyyev, Charyyar

    In this paper, we consider an inverse elliptic problem with Neumann type overdetermination and construct a fourth order of accuracy difference scheme for its solution. Stability, almost coercive stability and coercive stability estimates for the solution of difference problem are proved. Later, we construct a fourth order difference scheme for an inverse problem for multidimensional elliptic equation with Neumann type overdetermination and Dirichlet boundary condition. Finally, we illustrate numerical example with descriptions of numeric realization in a two-dimensional case.

    AtıfScopus19WoS12OpenAlex17
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  • MakaleAçık Erişim2017Scopus SJRQ1
    Antiproliferative and apoptotic effect of Morus nigra extract on human prostate cancer cells

    Turan, Ibrahim; Demir, Selim; Kilinc, Kagan; Burnaz, Nesibe Arslan; Yaman, Serap Ozer; Akbulut, Kubra; Mentese, Ahmet; Aliyazicioglu, Yuksel; Deger, Orhan

    Background: Morus nigra L. belongs to the family Moraceae and is frequently used in traditional medicine. Numerous studies have investigated the antiproliferative effects of various extracts of different Morus species, but studies involving the in vitro cytotoxic effect of M. nigra extract are very limited. The purpose of this study was to evaluate the phenolic composition and antioxidant activity of dimethyl sulfoxide extract of M. nigra (DEM) and to investigate, for the first time, the probable cytotoxic effect in human prostate adenocarcinoma (PC-3) cells together with the mechanism involved. Methods: Total polyphenolic contents (TPC), ferric reducing antioxidant power (FRAP) and phenolic compounds of DEM were evaluated using spectrophotometric procedures and HPLC. The cytotoxic effect of DEM on PC-3 cells was revealed using the MTT assay. Mechanisms involved in the cytotoxic effect of DEM on PC-3 cells were then investigated in terms of apoptosis, mitochondrial membrane potential and cell cycle using flow cytometry, while caspase activity was investigated using luminometric analysis. Results: TPC and FRAP values were 20.7 ± 0.3 mg gallic acid equivalents and 48.8 ± 1.6 mg trolox equivalents per g sample, respectively. Ascorbic acid and chlorogenic acid were the major phenolic compounds detected at HPLC analysis. DEM arrested the cell cycle of PC-3 cells at the G1 phase, induced apoptosis via increased caspase activity and reduced mitochondrial membrane potential. Conclusions: Our results indicate that M. nigra may be a novel candidate for the development of new natural product based therapeutic agents against prostate cancer.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus71WoS66OpenAlex78
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  • MakaleAçık Erişim2017Scopus SJRQ2
    Excited Neutrino Search Potential of the FCC-Based Electron-Hadron Colliders

    Caliskan, A.

    The production potential of the excited neutrinos at the FCC-based electron-hadron colliders, namely, the ERL60⊗FCC with √s = 3.46 TeV, the ILC⊗FCC with √s = 10 TeV, and the PWFA-LC⊗FCC with √s = 31.6 TeV, has been analyzed. The branching ratios of the excited neutrinos have been calculated for the different decay channels and shown that the dominant channel is ∗→eW+. We have calculated the production cross sections with the process of ep→∗q→eW+q and the decay widths of the excited neutrinos with the process of ∗→eW+. The signals and corresponding backgrounds are studied in detail to obtain accessible mass limits. It is shown that the discovery limits obtained on the mass of the excited neutrino are 2452 GeV for Lint=100 fb-1, 5635 GeV for Lint=10 fb-1 (6460 GeV for Lint=100 fb-1), and 10200 GeV for Lint=1 fb-1 (13960 GeV for Lint=10 fb-1), for the center-of-mass energies of 3.46, 10, and 31.6 TeV, respectively.

    AtıfScopus10WoS10OpenAlex13
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  • MakaleAçık Erişim2017Scopus SJRQ2
    Phenolic characterisation and antioxidant activity of Primula vulgaris and its antigenotoxic effect on fibroblast cells

    Ozkan, Mehtap Tugce; Aliyazicioglu, Rezzan; Demir, Selim; Misir, Sema; Turan, Ibrahim; Yildirmis, Sermet; Aliyazicioglu, Yuksel

    Background: Primula vulgaris has been used in traditional treatment, and its biological functions are attributed to its polyphenolics content. Objectives: The aim of this study was to determine the phenolics composition and the antioxidant activity of water extract of P. vulgaris (WEP) and to determine its probable preventive effects against H2O2-induced DNA damage in human fibroblast cells. Methods: The total polyphenolic content (TPC), ferric reducing antioxidant power (FRAP), and radical scavenging activity of WEP were determined using spectrophotometric methods. Phenolic compounds and antigenotoxic effects of WEP were evaluated using HPLC and comet assay, respectively. Results: The TPC and FRAP values of WEP were 15.023 ± 0.84 mg gallic acid and 82.63 ± 0.31 μM trolox per g sample, respectively. ρ-coumaric acid and rutin were detected as major phenolics. Moreover, WEP reducedH2O2-induced DNA damage in a concentration dependent manner in fibroblast cells compared to the positive controls (only 20 μMH2O2 treatment). Conclusions: Primula vulgaris can be used in food, cosmetics, and drug industries because of its antioxidant and antigenotoxic activities.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus26WoS30OpenAlex25
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  • MakaleYalnız künye2017Scopus SJRQ3
    The effect of plasma electrolytic oxidation process parameters on the tribocorrosion properties of TiO2 coatings

    Sukuroglu, Ebru Emine; Farzi, Hamed; Sukuroglu, Suleyman; Totik, Yasar; Arslan, Ersin; Efeoglu, Ihsan

    Despite the fact that Titanium and its alloys are materials which have excellent corrosion-resistant properties, they have poor wear and friction performance under tribological conditions. The aim of this study is to find suitable parameters for the surface treatment of Cp-Ti substrates which are used under saline environment. In this study, TiO2 coatings were grown on Cp-Ti substrates at different frequencies which are parameters of the coating process. Due to its low cost and ability to achieve high thicknesses, The Plasma Electrolytic Oxidation (PEO) method was applied to grow TiO2 coatings. The microstructures, morphology, and crystallographic structure were analyzed using SEM and XRD. Tribocorrosion properties of the coatings were investigated using a combination of the pin-on-disk wear test and potentiodynamic polarization test units. The frequency is known to have a strong impact on the PEO process. The impacts of frequency changes on the PEO coating performance were examined under a constant voltage. As result, the increase of the frequency caused smaller pores and cracks in the surface morphology of the coating and at the same time this yielded an increment on the tribocorrosion behavior of the coating.

    AtıfScopus20WoS18OpenAlex18
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  • MakaleYalnız künye2017Scopus SJRQ2
    The operator method for local fractional linear differential equations

    Ünal, Emrah; Gökdoğan, Ahmet; Cumhur, İshak

    In this work, we give the particular solution for nonhomogeneous sequential linear conformable fractional differential equations with constant coefficients by using the operator method.

    AtıfScopus9WoS7OpenAlex9
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  • MakaleAçık Erişim2017Scopus SJRQ2
    Comparison of stochastic and random models for bacterial resistance

    Merdan, Mehmet; Bekiryazici, Zafer; Kesemen, Tulay; Khaniyev, Tahir

    In this study, a mathematical model of bacterial resistance considering the immune system response and antibiotic therapy is examined under random conditions. A random model consisting of random differential equations is obtained by using the existing deterministic model. Similarly, stochastic effect terms are added to the deterministic model to form a stochastic model consisting of stochastic differential equations. The results from the random and stochastic models are also compared with the results of the deterministic model to investigate the behavior of the model components under random conditions.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus25WoS25OpenAlex25
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  • MakaleYalnız künye2017Scopus SJRQ1
    Nothing is more important than my partner's health: Turkish men's perspectives on partner's appearance after mastectomy and alopecia

    Gürsoy, Ayla; Koçan, Sema; Aktuğ, Cemile

    Purposes The aim of this study was to acquire a deeper understanding of male experiences on the emotional and social impact of their partners’ mastectomy and chemotherapy-induced alopecia. Methods A purposive sample of 16 males whose partners had undergone mastectomy and alopecia due to chemotherapy was chosen. The data were collected through a semi-structured interview method. Interpretative Phenomenological Analysis of tape-recorded interviews was employed. Results Two main themes emerged from the data: facing the changes and my wife and I at present. Male partners were affected differently by the change in the physical appearance of their female partners. Our study participants said it was a difficult experience to see their partners for the first time after the surgery, but they emphasized that it was more important that their partners were healthy than the fact that they did not have a breast and hair. They also said they did not know how to behave towards their partners after surgery and/or chemotherapy. Nevertheless, they felt that the disease process of their partners had strengthened their bond and had not negatively influenced their relationship with others. Conclusions The changes in the partners’ physical appearance after mastectomy and chemotherapy affected males differently in psychological, emotional and social terms. Since nurses working in this field are in contact with patients during all phases of treatment and care, it would be positive and beneficial to plan nursing interventions that give emotional support for male partners of patients with breast cancer.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus8WoS8OpenAlex12
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  • MakaleYalnız künye2017Scopus SJRQ3
    Approximate solution for an inverse problem of multidimensional elliptic equation with multipoint nonlocal and neumann boundary conditions

    Ashyralyyev, Charyyar; Akyuz, Gulzipa; Dedeturk, Mutlu

    In this work, we consider an inverse elliptic problem with Bitsadze-Samarskii type multipoint nonlocal and Neumann boundary conditions. We construct the first and second order of accuracy difference schemes (ADSs) for problem considered. We stablish stability and coercive stability estimates for solutions of these difference schemes. Also, we give numerical results for overdetermined elliptic problem with multipoint Bitsadze-Samarskii type nonlocal and Neumann boundary conditions in two and three dimensional test examples. Numerical results are carried out by MATLAB program and brief explanation on the realization of algorithm is given.

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  • MakaleAçık Erişim2017Scopus SJRQ3
    Production of structured lipid with a low omega-6/omega-3 fatty acids ratio by enzymatic interesterification

    Ilyasoglu, H.

    A structured lipid (SL) constituting omega fatty acids was synthesized by using linseed and grape seed oils as substrates via a lipase-catalyzed reaction. Lipozyme® TL IM was used as a biocatalyst. Good quadratic models predicting the incorporation of omega fatty acids were achieved via the Response surface methodology (RSM). The optimal conditions for targeted omega-6/omega-3 fatty acid ratio (2:1) were obtained at a substrate molar ratio 1.4, time 8.4 h, and enzyme amount 6.4%. The SL contained linoleic acid (43 g 100g-1), which was mainly located in the sn-2 position (40 g 100g-1). α-Linoleic acid, and α-linolenic acid at the sn-2 position were 22 g 100g-1, and 11 g 100g-1, respectively. The oxidative stability of the SL, and SL with antioxidants was also investigated. The produced SL may be proposed as a source of a balanced intake of omega fatty acids and an ingredient in functional food formulations.

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  • MakaleAçık Erişim2017Scopus SJRQ4
    Association of IGF and IGFBP2 gene polymorphisms with growth and egg traits in Atak-S laying hens

    Das, Huseyin; Tarim, B.; Demir, S.; Küçükkent, N.; Cengiz, S.; Tülek, E.; Aksakal, V.

    Atak-S laying hens are a high-performance hybrid obtained by crossing of the Rhode Island Red (RIR) X the Barred Plymouth Rock (BR) and are being produced in the Ankara Poultry Research Institute since 1997. Phenotypic and genetic improving studies are continuous for this hybrid. In this study three different SNPs, two from IGF1 and one from IGFBP2 genes, were examined in 150 Atak-S chickens. Genetic association of SNPs were compared to body weight and egg number till 32 weeks of age, body weight at sexual maturity, age at sexual maturity and also egg quality traits such as egg shell breaking strength, shell thickness, Haugh unit, albumen index, yolk index and shape index were statistically analyzed. Only IGF1(a) locus was in agreement with Hardy-Weinberg equilibrium, while, the rest of the loci were not. As a result of the comparisons performed to the three SNPs, it was determined that there was a significant association (P < 0.05) between the T364C haplotypes of the IGF1(b) locus and body weight at 32 weeks of age, but there was not any association to the other traits.

    • SDG 2 · Açlığa Son
    AtıfScopus3WoS2OpenAlex4
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  • MakaleAçık Erişim2017Scopus SJRQ3
    Numerical solution to Bitsadze-Samarskii type elliptic overdetermined multipoint NBVP

    Ashyralyyev, Charyyar

    This paper is devoted to a Bitsadze-Samarskii type overdetermined multipoint nonlocal boundary value problem (NBVP). This inverse problem is reduced to an auxiliary multipoint NBVP. Stability estimates for the solution of the auxiliary NBVP are established. The finite difference method is applied to get the first and second order of accuracy of approximate solutions of the abstract overdetermined problem. Stability estimates for the solution of difference problems are proved. Then the established abstract results are applied to get stability estimates for the solution of the Bitsadze-Samarskii type overdetermined elliptic multidimensional differential and difference problems with multipoint nonlocal boundary conditions (NBVC). Finally, numerical results with explanation on the realization for two dimensional and three dimensional elliptic overdetermined multipoint NBVPs in test examples are presented.

    AtıfScopus30WoS23OpenAlex27
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  • MakaleAçık Erişim2017Scopus SJRQ3
    Morus rubra extract induces G1 cell cycle arrest and apoptosis in human lung and prostate cancer cells

    Turan, Ibrahim; Demir, Selim; Kilinc, Kagan; Aliyazicioglu, Yuksel; Alver, Ahmet; Misir, Sema; Yaman, Serap Ozer; Akbulut, Kubra; Mentese, Ahmet; Deger, Orhan

    Objective: Cancer is one of the most deadly types of disease and evasion from apoptosis and unstoppable cell proliferation are accepted as its distinctive features. Many studies have evaluated the cytotoxic effect of different Morus species but, there is no study about cytotoxic effect of Morus rubra. In this study we aimed to evaluate phenolic composition, antioxidant properties and cytotoxic effect of acidified dimethyl sulfoxide extract of M. rubra (AMRE). Method: Antioxidant properties, phenolic composition and cytotoxic effect of AMRE were determined using spectrophotometric methods, HPLC, and MTT assay, respectively. Then, mechanisms of cytotoxic effect of AMRE on human prostate (PC-3) and lung (A549) cancer cells were examined in regard to cell cycle, apoptosis and mitochondrial membrane potential using flow cytometric methods. Results: Total phenolic content and reducing power values were 11.9 mg gallic acid equivalents and 42.9 mg trolox equivalents per g sample, respectively. Ascorbic and gallic acid were detected in AMRE as major antioxidant compounds. We determined that AMRE increased cell cycle arrest at G1 phase and exhibited apoptotic features via decreasing mitochondrial membrane potential in both prostate and lung cancer cells. Conclusion: These findings demonstrate that M. rubra extract can affect the behavior of human prostate and lung cancer cells in vitro conditions, and this effect now needs to be investigated in vivo.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus5WoS11OpenAlex11
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  • MakaleAçık Erişim2017Scopus SJRQ3
    Cytotoxic effect of Laurocerasus officinalis extract on human cancer cell lines; [Laurocerasus officinalis ekstraktının İnsan kanser hücre serileri üzerindeki sitotoksik etkisi]

    Demİr, Selim; Turan, İbrahim; Demİr, Feyza; Ayazoğlu Demİr, Elif; Alıyazicioğlu, Yuksel

    Laurocerasus officinalis Roem. (Prunus laurocerasus L.), also locally known as “karayemis or taflan”, is a popular black summer fruit belonging to the genus Prunus and the family Rosaceae. L. officinalis exhibits numerous biological activities, such as anti-inflammatory, antinociceptive, antioxidant, neuroprotective, and antidiabetic effects. The aim of this study was to determine the total phenolic content and cytotoxic effect of dimethyl sulfoxide extract of L. officinalis (DEL). The total phenolic content and cytotoxic effect of DEL were investigated using the Folin-Ciocalteu method and thiazolyl blue tetrazolium bromide (MTT) assay, respectively. Total phenolic content value was 33.7±0.13 mg gallic acid equivalent per g sample. DEL exhibited selective cytotoxic effects against four human cancer (lung, colon, liver, and cervix) cell lines. The most selective cytotoxic effect of the extract was observed in colon cancer cells (IC50=265.2±8.1 μg/mL) compared to normal fibroblast cells. These data demonstrate that L. officinalis extract exhibits selective cytotoxicity towards some cancer cells. Further studies are now needed to clarify the molecules involved and their mechanisms.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus17WoS21OpenAlex34TR Dizin14
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  • MakaleAçık Erişim2017Scopus SJRQ3
    Effect of the Simultaneous Variation in Blade Root Chord Length and Blade Taper on Helicopter Flight Control Effort

    Oktay, Tugrul; Sal, Firat

    In this study, the effect of simultaneous variation in blade root chord length and blade taper on the control effort of helicopter flight control system (i.e., FCS) of a helicopter is investigated. Therefore, helicopter models (i.e., complex, control-oriented, and physics-based models) including the main physics and essential dynamics are used. The effect of simultaneous variation in the blade root chord length and blade taper (i.e., in both chordwise and lengthwise directions dependently) on the control effort of an FCS of a helicopter and also on the closed-loop responses is studied. Comparisons in terms of the control effort and peak values with and without variations in the blade root chord and blade taper changes are carried out. For helicopter FCS variance-constrained controllers, specific output variance-constrained controllers are beneficial.

    AtıfScopus13WoS11OpenAlex16
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  • MakaleAçık Erişim2017Scopus SJRQ3
    Diversity and ecology of benthic diatoms in karagöl lake in karagöl-Sahara national park (Şavşat, Artvin, Turkey)

    Akar, Bülent; Şahin, Bülent

    The main goal of this study is to determine the composition, diversity and ecology of benthic diatoms in Karagöl Lake in Karagöl-Sahara National Park. Monthly sampling (from sediments, stones and aquatic plants in littoral zone of the lake) taken in three consecutive years revealed 57 diatom taxa with Gomphonema and Pinnularia being the most abundant species while other genera are represented with three or fewer species. Lindavia ocellata was the most dominant taxon in the samplings examined throughout the whole study. The values of diversity and evenness indices are high during the spring and early summer. Based on cluster analysis for monthly samples of epipelic diatom, there are two different groups at the lowest similarity level. The associations between August 2010 and September 2010 months are the most significant with 86.02%. The organism number of epipelic diatoms showed positive correlation (P<0.01) with dissolved oxygen, while negative correlation (P<0.05) with temperature. Detailed floristic and ecological examination of the benthic diatom communities has not been carried out before this study in this lake. Therefore, this study is the first to our knowledge towards revealing aquatic benthic diatom biodiversity of Karagöl-Sahara National Park and provides basis for future investigations.

    AtıfScopus7WoS9OpenAlex4
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  • MakaleYalnız künye2017Scopus SJRQ2
    Morus Rubra Extract Induces Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells Through Endoplasmic Reticulum Stress and Telomerase

    Demir, Selim; Turan, Ibrahim; Aliyazicioglu, Yuksel; Kilinc, Kagan; Yaman, Serap Ozer; Ayazoglu Demir, Elif; Arslan, Ayse; Mentese, Ahmet; Deger, Orhan

    Many studies have reported cytotoxic effects of different Morus species, but there have been only limited studies on the cytotoxic effect of Morus rubra. The aims of this study were to evaluate the cytotoxic effect of dimethyl sulfoxide extract of M. rubra and to investigate, for the first time, its probable cytotoxic activity in human colon cancer (WiDr) cells, together with the mechanism involved. The cytotoxic activity of extract was determined using MTT assay. The mechanism involved in the cytotoxic effect of extract was then evaluated in terms of apoptosis, and the cell cycle using flow cytometry, mitochondrial membrane potential (MMP) was investigated using the fluorometric method, and expression levels of telomerase and C/EBP homologous protein (CHOP) were investigated using reverse-transcription PCR (RT-PCR). M. rubra extract exhibited moderate selective cytotoxicity on colon cancer cells compared with fibroblast cells. Extract induced cell cycle arrest at the G1 phase and apoptosis via reduced MMP in WiDr cells. Additionally, M. rubra extract significantly repressed telomerase and induced CHOP expressions in WiDr cells. Our results demonstrate that targeting telomerase and endoplasmic reticulum stress represents a promising strategy in colon cancer therapy, and M. rubra may have considerable potential for development as a novel natural product-based anticancer agent.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus23WoS24OpenAlex25
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  • MakaleYalnız künye2017Scopus SJRQ2
    Stability Estimates for Solution of Neumann-Type Overdetermined Elliptic Problem

    Ashyralyyev, Charyyar

    This paper addresses estimation of the solution of inverse problem for the elliptic type equation with second kind boundary conditions and Neumann-type overdetermination at the interior point. We prove various estimates for the solution of this identification problem. Then, the first order accuracy stable difference scheme is studied. The stability, almost coercive stability, and coercive stability inequalities for its solution are obtained. The theoretical results can be applied to investigate identification problems for multidimensional elliptic equation with different kind of boundary conditions.

    AtıfScopus28WoS18OpenAlex26
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  • MakaleYalnız künye2017Scopus SJRQ2
    Characterization of Grape Molasses/Sesame Paste/Honey Blends: Multiple Response Optimization of Some Physicochemical, Bioactive, Viscoelastic and Sensory Properties

    Karaman, Safa; Yilmaz, Mustafa Tahsin; Ozturk, Gokturk; Yuksel, Ferhat; Toker, Ömer Said; Dogan, Mahmut

    In this study, blends of grape molasses, sesame paste and honey were prepared at different ratios according to the mixture design and some physicochemical, rheological, bioactive and sensory properties of final blends were studied to create the optimum formulation for the final product. The results showed that the mixture components had significant change on the studied parameters (P < 0.05). Sugar composition of samples changed significantly by the addition of grape molasses and honey which resulted an increase in fructose and glucose. Grape molasses increase in the blend provided a significant increment in total phenolic content and antiradical activity. The blends had viscoelastic character and the mixtures containing higher honey showed more viscous behavior. The highest complex viscosity values were recorded for the blends of sesame paste and honey. Regression models having quite high determination of coefficients (R2 > 0.71) were constructed for the studied parameters. Multiple response optimization results showed that the most preferred blend should contain 34.66% of grape molasses, 34.11% of sesame paste and 31.23% of honey. Practical Applications: Grape molasses, honey and sesame paste are commonly consumed food products which are rich in energy and many functional components. The people generally consume them in their daily diets especially in their breakfasts. To combine their functionality and sensory properties, an optimization procedure was applied and the mostly desired blend was determined. Blending affected the rheological, textural and bioactive properties of the sample significantly. The results of the study are very important for food industry.

    • SDG 2 · Açlığa Son
    AtıfScopus16WoS15OpenAlex15
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  • MakaleYalnız künye2017Scopus SJRQ2
    Improving by postoxidation of corrosion resistance of plasma nitrocarburized AISI 316 stainless steels

    Yenilmez, A.; Karakan, M.; Çelik, I.

    Austenitic stainless steels are widely used in several industries such as chemistry, food, health and space due to their perfect corrosion resistance. However, in addition to corrosion resistance, the mechanic and tribological features such as wear resistance and friction are required to be good in the production and engineering of this type of machines, equipment and mechanic parts. In this study, ferritic (FNC) and austenitic (ANC) nitrocarburizing were applied on AISI 316 stainless steel specimens with perfect corrosion resistance in the plasma environment at the definite time (4 h) and constant gas mixture atmosphere. In order to recover corrosion resistance which was deteriorated after nitrocarburizing again, plasma postoxidation process (45 min) was applied. After the duplex treatment, the specimens’ structural analyses with XRD and SEM methods, corrosion analysis with polarization method and surface hardness with microhardness method were examined. At the end of the studies, AISI 316 surface hardness of stainless steel increased with nitrocarburizing process, but the corrosion resistance was deteriorated with FNC (570 °C) and ANC (670 °C) nitrocarburizing. With the following of the postoxidation treatment, it was detected that the corrosion resistance became better and it approached its value before the process.

    AtıfScopus9WoS5OpenAlex10
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