Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Düzgün, Azer Özad(9)
- Akar, Zeynep(6)
- Baltaci, Cemalettin(5)
- Acet, Tuba(3)
- Kardil, Ugur(3)
- Sarıyer, Aysegül Saral(3)
- Akmeşe, Osman(2)
- Akyildiz, Esma(2)
- Karpuz, Omer(2)
- Köse, Tuba(2)
- Kıvanç, Aydın(2)
- Ozcan, Kadriye(2)
- Türkmen, Lale(2)
- Akar, Bülent(1)
- Arık, Sevgi(1)
- Aslan, Nazife Aslan(1)
- Aydin, Aydanur(1)
- Aygün, Gökhan(1)
- Bahar, Bilge(1)
- Bakir, Esra(1)
- Bekiryazıcı, Zafer(1)
- Beris, Fatih Saban(1)
- Borsa, Barış Ata(1)
- Can, Zehra(1)
- Cengiz, Sevil(1)
- Darak, Münevver(1)
- Demir, Elif Ayazoglu(1)
- Erkaya, Tuba(1)
- Esen, Ümmü Gülsüm Esen(1)
- Gençer, Sevil(1)
- Gültekin, Enes(1)
- Gürbüz, Zeynep(1)
- Gürmeriç, Hüseyin Ender(1)
- Gıdık, Betül(1)
- Kara, Yakup(1)
- Karakullukçu, Asiye(1)
- Karakullukçu, Volkan(1)
- Kardil, Uğur(1)
- Kaya, Afşin Ahmet(1)
- Kesemen, Tülay(1)
Yayınlar
- MakaleAçık Erişim2025Assessment of antioxidant, antimicrobial, antibiofilm, carbonic anhydrase and α-glucosidase inhibitory activities of Alchemilla vulgaris L. extracts
Düzgün, Azer Özad; Akar, Zeynep; Kardil, Ugur
This study was to investigate the biological properties (antioxidant, enzyme inhibitory and antimicrobial activity) of water extract (WE), 50:50% water:ethanol extract (WEE) and ethanol extract (EE) of aerial parts of Alchemilla vulgaris L. which was traditionally used to alleviate and treat many diseases. The WEE extract exhibited the highest total phenolic content (TPC), with a value of 612 µg/mL GAE, while the EE extract demonstrated the highest total flavonoid content (TFC), with a value of 0.086 µg/mL GAE. Also, the data demonstrated that the WEE extract exhibited the highest radical scavenging capacities and antioxidant activities, exhibiting 0.0056, 0.0028 mg/mL SC50 and 267, 0.081 μM TEAC, as determined by the DPPH, ABTS, FRAP and CUPRAC assays, respectively. The WEE extract was found to be an effective bovine carbonic anhydrase (BCA) and α-glucosidase inhibitor with an IC50 values of 0.0628 and 0.0535 mg/mL, respectively. The EE extract showed activity against both Gram-negative and Gram-positive bacteria used in the study. EE extract has the highest activity against Yersinia pseudotuberculosis and the lowest activity against Streptococcus pyogenes. Furthermore, the extracts significantly reduced the biofilm ability of Acinetobacter baumannii isolate, which has strong biofilm ability. EE and WE reduced the biofilm formation capacity of the strain to a weak level, while WEE extract reduced it to a moderate level. The results suggest that EE has a significant effect in combating antibiotic resistance, while WEE has high antioxidant activity and good inhibitory effect against BCA and α-glycosidase enzymes. In addition, the results revealed that solvent extracts with different solvent composition and polarity may have different effects on diverse bioactivity tests.
- Derleme MakaleAçık Erişim2025Gerobiyotikler, Yaşlanma ve Mikrobiyota
Konyalıgil, Nurefşan; Kurtbeyoğlu, Emine
Yaşlanma, birçok kronik hastalık ve işlevsel gerileme için ortak bir risk faktörü olarak kabul edilmektedir. Yaşlı popülasyonda sağlığı koruma ve yaşam kalitesini iyileştirmede probiyotiklerin profilaktik kullanımının faydaları konusunda artan bir farkındalık vardır. Yaşlanmanın temel mekanizmalarını faydalı bir şekilde zayıflatabilen, fizyolojik yaşlanma süreçlerini azaltabilen ve böylece konağın sağlıklı yaşam süresini uzatabilen probiyotik suşları ve bunlardan türetilen postbiyotik ve para-probiyotikleri tanımlamak için yeni bir terim olan “gerobiyotikler” kullanılmaktadır. Gerobiyotiklerin kullanımı, gelecekte insanların sağlıklı yaşam süresini uzatmak için umut verici bir müdahale stratejisi olabilir. Ancak sağlıklı yaşlanmayı sağlamada etkili olduğunu gösterebilmek için daha fazla klinik çalışmaya ve daha uzun süreli müdahalelere ihtiyaç vardır.
- MakaleAçık Erişim2025Phytogenic Silver and Copper Nanoparticles from Morus nigra L. Leaf as Multifunctional Agents: Antioxidant, Antidiabetic, Antimicrobial, and Anticancer Potency
Çam Derin, Dilek; Baltaci, Cemalettin; Akmeşe, Osman; Taskin, Irmak Icen; Karpuz, Omer; Gültekin, Enes; Sever, Meryem Rüveyda
The growing need for eco-friendly nanomaterials has directed attention toward plant-based green synthesis as a sustainable approach for biomedical applications. This study reports the biosynthesis of silver (YAgNPs) and copper nanoparticles (YCuNPs) using Morus nigra L. leaf extract and evaluates their multifunctional properties. The nanoparticles were produced under alkaline aqueous conditions, and their crystalline nature and nanoscale morphology were confirmed by standard structural and elemental analyses. Both YAgNPs and YCuNPs exhibited enhanced antioxidant capacities compared to the crude extract. YAgNPs showed the highest ferric reducing antioxidant power (250.33 mg FeSO₄/g), while YCuNPs demonstrated superior DPPH radical scavenging activity (114.12 mg AAE/g). In antidiabetic assays, YAgNPs strongly inhibited α-amylase (IC₅₀ = 112.02 μg/mL) and α-glucosidase (IC₅₀ = 38.27 μg/mL), approaching the potency of acarbose. Antimicrobial analysis revealed distinct activity profiles: YAgNPs were highly effective in broth cultures with low MIC and MBC values (0.09–0.18 mg/mL against B. subtilis and E. coli), whereas YCuNPs achieved larger inhibition zones in diffusion assays. Checkerboard testing confirmed synergistic interactions between nanoparticles and antibiotics, with FICI values ≤0.5 against E. faecium, E. coli, and P. aeruginosa, highlighting their ability to enhance antibiotic efficacy. YAgNPs exhibited notable cytotoxic effects against HeLa and HCT116 cancer cell lines, with IC₅₀ values of 9.84 and 6.83 μg/mL, respectively. In contrast, YCuNPs displayed weaker anticancer activity. Overall, these findings demonstrate that M. nigra derived nanoparticles combine antioxidant, antidiabetic, antimicrobial, and anticancer activities with synergistic antibiotic-enhancing effects, underscoring their potential as sustainable, multifunctional therapeutic agents.
AtıfOpenAlex1
İncele - MakaleAçık Erişim2024Endemik Onosma nana DC.’nin Kimyasal Bileşimi, Antimikrobiyal, Antioksidan ve Enzim İnhibisyon Aktivitesinin Araştırılması
Ozcan, Kadriye; Acet, Tuba
Türkçe adı “Emzik otu” olarak bilinen Onosma türleri, etnobotanik açıdan oldukça değerlidir. Bu çalışmada, Onosma nana’nın toprak üstü ve kök kısımlarının farklı çözücülerle (etanol, metanol ve etil asetat) elde edilen ekstrelerinin antioksidan, antimikrobiyal, enzim inhibisyon (α-amilaz, α-glukozidaz ve tirozidaz) ve DNA koruyucu aktivitesi ile fenolik bileşen analizinin (HPLC) yapılması amaçlanmıştır. Elde edilen sonuçlara göre, etanol ekstrelerinin diğer ekstrelere nazaran araştırılan özellikler bakımından daha etkin olduğu bulunmuştur. Etanol ekstrelerinin major fenolik bileşeni rosmarinik asit (kök: 2883.3 μg/g ekstre, toprak üstü: 11187.5 μg/g ekstre) olarak tespit edilmiştir. Sonuç olarak, bitkinin oldukça etkili antimikrobiyal aktiviteye sahip olduğu bulunmuştur (S. epidermidis ve P. vulgaris: MİK 32µg/mL). Bitkinin DNA koruyucu etkisi ve antimikrobiyal özellikleri ilk defa araştırılmıştır. Bitkinin doğal bir ajan olarak kullanılma potansiyeli olduğu söylenebilir. Bunun yanısıra, tespit edilen aktivitelerin detaylı çalışmalarla desteklenerek etki mekanizmalarının aydınlatılması ticari öneminin anlaşılması bakımından gereklidir.
- Derleme MakaleAçık Erişim2024COVID-19’un QALY ve DALY Ölçütlerine Etkisi
Köse, Aslı
Amaç: Dünya’da COVID-19 salgını özellikle sağlık sistemleri olmak üzere birçok sistemi etkilemiştir. Sağlık harcamalarında artan talep maliyetlerin de artışına neden olmuştur. Dolayısıyla sağlık ölçütleri olarak kaliteye göre ayarlanmış yaşam yılları (Quality-Adjusted Life-Year; QALY) ve engelliliğe göre ayarlanmış yaşam yılları (Disability-Adjusted Life Year; DALY) başına düşen maliyetlerin değerlendirilmesi sağlık yöneticilerinin karar süreçlerini destekleyecektir. Bu sistematik derlemenin amacı, COVID-19’un QALY ve DALY ölçütlerine etkisini değerlendirmektir. Gereç ve Yöntem: Sistematik derlemede PRISMA bildirgesi rehber alınmıştır. Araştırma stratejisinde üç elektronik veri tabanı kullanılmıştır: Scopus, Web of Science, PUBMED. Veri tabanları 01/01/2020-31/12/2022 tarihleri arasında taranmıştır. Taramalarda “COVID-19” and “QALY” ile “COVID-19” and “DALY” anahtar kelimeleri kullanılmıştır. Bulgular: Veri tabanlarından ulaşılan araştırma sayısı 352’dir. Ayrıntılı incelenen araştırma sayısı 290’dır. Derlemeye 37 çalışma dahil edilmiştir. Gerçekleşen ve tahmini verilere dayalı araştırmalarda farklı QALY ve DALY ölçütlerine ulaşılmıştır. Aşı, ilaç ve PCR testlerinin uygulanması ile elde edilen sağlık kazanımları da değişmiştir. Sonuç: COVID-19 pandemi döneminde QALY ve DALY sağlık çıktılarının ülkelerin sağlığa ayırdıkları kaynaklar ve sağlık sistemlerinin özelliklerine göre değişkenlik gösterdiği belirlenmiştir.
- MakaleAçık Erişim2024Investigation of antibiofilm and biological activities of Vaccinium arctostaphylos L.
Düzgün, Azer Özad; Akar, Zeynep; Kardil, Ugur
This study investigated the total phenolic and flavonoid contents and the antioxidant, antimicrobial, antibiofilm and α-glucosidase inhibitory activities of methanol extract from Vaccinium arctostaphylos L. leaf and fruit parts. The highest antioxidant activity with 53 µM TEAC and 0.0084 mg/mL SC50 using the ferric reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays, respectively determined in leaf part. The data indicated that the leaf of the plant had the higher total phenolic content (49 µg/mL GAE) and total flavonoid content (0.071 µg/mL QAE) compared to fruit. The α-glucosidase enzyme activity of the leaves (0.179 mg/mL IC₅₀) was observed to be higher than that of the fruits (0.386 mg/mL IC₅₀). The MIC values of the leaf and fruit parts of blueberry were 6.25 mg/ml and 3.125 mg/ml, respectively. The results of this study indicate that the leaf extract was found to significantly reduce the biofilm-forming capacity of the Acinetobacter baumannii isolate by approximately 3-fold, whereas the fruit extract was observed to have only a marginal effect, reducing the biofilm-forming capacity by approximately 1.4-fold. The effects of plant extracts on microbial biofilms may be examined with a view to combating antibiotic resistance. Also results suggesting that it might be an effective and safety medical plant to prevent or treat diseases associated with oxidative damage and bacterial infections. Consequently, further research on natural substances may lead to the development of treatment options.
AtıfTR Dizin2İncele - MakaleAçık Erişim2024Isothermal inactivation kinetics of Salmonella and Enterococcus faecium NRRL B-2354 in oat flour
Ozturk, Samet
Bu çalışma, Salmonella'nın ısıl işlemin sırasında yulaf ununda hayatta kalma ve ısıl toleransını (D- ve z-değerleri) patojenik etki göstermeyen potansiyel müdavini olan Enterococcus faecium NRRL B-2354 (E. faecium) ile birlikte belirlemeyi amaçlamıştır. Yulaf ununun su aktivite (aw) değeri , nem kontrollü bir ortamda 0.40 olarak ayarlanarak S. Enteritidis PT30 ve E. faecium ile eşit şekilde inoküle (108-9 CFU/g) edilmiştir. Yulaf unu örnekleri (1 ± 0.1 g) daha sonra plastik torbalarda vakumlanarak paketlenmiş ve bakteriyel hayatta kalmayı değerlendirmek için 75, 80 ve 85°C’de sıcak su banyosunda ısıl işleme tabi tutulmuştur. S. Enteritidis PT30 ve E. faecium'un hayatta kalma eğrileri, iki ana model (Log-lineer ve Weibull modeli) kullanılarak analiz edilmiştir ve mikroorganizmaların hayatta kalma eğrilerinin birinci dereceden kinetik izlediği ortaya çıkmıştır. S. Enteritidis PT30 ve E. faecium'un yulaf unundaki D75C, D80C ve D85C değerleri sırasıyla 16.08 ± 1.36°C'den 2.27 ± 0.35 dakikaya ve 23.61 ± 1.39'dan 3.87 ± 0.42 dakikaya düşmüştür ve karşılık gelen z-değerleri sırasıyla 13.4 ± 0.37 ve 12.1 ± 0.41°C olarak bulunmuştur. Bu araştırmadan elde edilen D- ve z-değerleri, yulaf ununun mikrobiyel güvenliğini sağlamak için ısıl işlemin doğrulanmasında kullanılabilir.
- MakaleAçık Erişim2024Vitis Labrusca L. Kabuk Ekstraktlarının Antibiyofilm, Antidiyabetik ve Antioksidan Potansiyelleri
Düzgün, Azer Özad; Akar, Zeynep; Kardil, Ugur
Bu çalışmada, Vitis labrusca L. bitkisinin kabuk kısımlarından elde edilen metanol, 50:50% metanol:su ve su ekstraktlarının antioksidan, antimikrobiyal, antibiyofilm ve α-glukozidaz inhibitör aktiviteleri ile toplam fenolik ve flavonoid içerikleri incelenmiştir. 50:50% metanol:su özütü, sırasıyla FRAP ve DPPH• radikal süpürücü analizleriyle belirlendiği üzere, 153 μM TEAC ve 0,0947 mg/mL SC50 ile en yüksek antioksidan aktiviteyi sergilemiştir. 50:50% metanol:su ekstraktı, sırasıyla 141 μg/mL GAE ve 0,103 mg/mL IC₅₀ değeri ile diğer çözücü ekstraktları arasında en yüksek toplam fenolik içeriği ve α-glukozidaz enzim inhibisyonunu sergilemiştir. Metanol, su ve 50:50% metanol:su ekstraktlarının MİK değerleri, klinik antibiyotik direnci olan Acinetobacter baumanii' ye karşı sırasıyla 6.25, 25 ve 12.5 mg/mL olarak belirlenmiştir. Metanol, su ve %50:50 metanol:su ekstraktlarının Acinetobacter baumannii izolatının biyofilm oluşturma kapasitesini sırasıyla yaklaşık 1.7, 1.6 ve 1.3 kat azalttığı bulunmuştur. Bulgular, 50:50% metanol:su ekstraktının en yüksek fenolik içerik, antioksidan aktivite ve α-glukozidaz inhibisyonu sergilediğini, metanol ekstraktının ise en belirgin antimikrobiyal ve antibiyofilm aktivitelerini gösterdiğini ortaya koymuştur. Araştırmamızın sonuçları, çeşitli çözücülerin ve bunların ilgili bileşimlerinin kullanımının biyolojik aktivitede önemli farklılıklar yaratma kapasitesine sahip olduğunu göstermektedir. Bu durum, V. labrusca kabuk bileşenlerinin oksidatif stres ve bakteriyel enfeksiyonlarla ilgili rahatsızlıkların ele alınmasında değerli bir yol olarak hizmet etme potansiyeline işaret etmektedir.
AtıfTR Dizin1İncele - MakaleAçık Erişim2024Effect of Different Storage Conditions and Infusion Times on Antioxidant and Antimicrobial Activites and Total Phenolic Content of Rosehip Fruits
Düzgün, Azer Özad; Acet, Tuba; Baltaci, Cemalettin; Akmeşe, Osman; Ural, Mustafa Nuri; Akar, Zeynep; Darak, Münevver; Kılınç, Kagan
Rosa canina L. (Rosehip) is a medicinal plant with strong antioxidant properties.The content of rosehip and accordingly its antioxidant capability may vary according to the way the fruits are used, storage, infusion, freezing and drying methods. In study, it was aimed to determine the antioxidant, antimicrobial activities in rosehip infusion products and extracts under these conditions. Fresh, frozen, dried and +40C stored fruits were infused at 90 degrees and infusion groups were formed. During infusion, samples were taken at 30, 60, 90, 120, 300 and 360th minutes and antioxidant activity (DPPH, FRAP and ABTS methods), total phenolic and total flavonoid contents (TPC and TFC), and antimicrobial activity were analyzed. In addition, phenolic compound content was investigated in 3 different extracts by HPLC method. Dried rosehip (DR) infusing samples were found to have the highest antioxidant activity, TPC and TFC compared to all groups (p-value ranged between 0.000 and 0.05).). Significant decreases were detected in the parameters according to storage and freezing times. A total of 8 phenolic compounds, the highest concentration of which was epicatechin, were detected in aqueous and ethanolic extracts of dried and stored at 40C rosehip (DR+40C) and dried rosehip (DR) fruits. For antimicrobial analysis, Total 7 different Gram (+) and (Gram (-) bacterial strains, were used. While antimicrobial activity was observed in the extracts, no activity was observed in the infusion products. It was determined that antioxidant activity increased during 360 minute infusion time, although it varied according to storage conditions.
AtıfOpenAlex3TR Dizin1İncele - MakaleAçık Erişim2023Helichrysum chionophilum’un uçucu yağının antioksidan ve antimikrobiyal aktiviteleri: Türkiye'nin endemik bir bitkisi
Ozcan, Kadriye; Acet, Tuba
Mikroorganizmalara bağlı olarak gelişen rahatsızlıklar günümüzde giderek tehlikeli bir hal almıştır. Özellikle, dirençli organizmalar ile mücadele noktasında, daha ucuz, doğal ve etkili yöntemlere ihtiyaç duyulmaktadır. Biyolojik olarak aktif bileşikleri barındıran bitki materyalleri bu manada ön plana çıkmaktadır. Bu nedenle, mevcut çalışmada, Gümüşhane'den toplanan Helichrysum chionophilum'dan elde edilen uçucu yağın antioksidan ve antimikrobiyal aktiviteleri araştırılmıştır. Uçucu yağ, Clevenger tipi bir aparat kullanılarak hidro-damıtma yönteminden elde edildi. Serbest radikal yakalama aktivitesi, DPPH (2,2-difenil-1-pikrilhidrazil) yöntemi kullanılarak belirlendi. Antimikrobiyal aktivite mikro dilüsyon yöntemi kullanılarak 17 bakteri ve 2 maya kullanılarak incelendi. Elde edilen bulgulara göre, H. chionophilum bitkisi radikal süpürme aktivitesinin IC50 değeri 260.0±0.2 µg/mL olarak bulunmuştur. Ayrıca, bitkinin uçucu yağı, Y. pseudotuberculosis (MIC: 16 µg/mL), S. epidermidis (MIC: 16 µg/mL) ve C. albicans (MIC: 16 µg/mL) ve C. tropicalis'e (MIC: 32 µg/mL) karşı olağanüstü antimikrobiyal aktivite göstermiştir. Elde edilen sonuçlar, endemik bir tür olan H. chionophilum ve uçucu yağlarının antioksidan ve antimikrobiyal özellikleri sayesinde yeni ve alternatif doğal bir ajan olarak kullanılabileceğini işaret etmektedir.
AtıfOpenAlex3TR Dizin2İncele - MakaleAçık Erişim2023Trabzon Fatih Devlet Hastanesinden İzole Edilen Klinik Acinetobacter baumannii ve Pseudomonas aeruginosa Suşlarında Antibiyotik Direnç Genlerinin Araştırılması
Sarıyer, Aysegül Saral; Düzgün, Azer Özad; Akyildiz, Esma; Köse, Tuba; Beris, Fatih Saban
Bu çalışmanın amacı Acinetobacter baumannii ve Pseudomonas aeruginosa izolatlarının antibiyotik duyarlılık profilini araştırmak ve bu izolatlarda direnç genlerinin varlığını belirlemektir. Direnç genlerinin tespiti PCR yöntemi ile değerlendirildi. Acinetobacter baumannii izolatlarında imipenem ve meropenem direnci sırasıyla %93,2 ve %91 olduğu görüldü. P. aeruginosa izolatlarında imipenem direnç oranı %53,9 ve meropenem direnç oranı %38,5 olarak belirlendi. Pseudomonas aeruginosa izolatları arasında aranan genlerden bir izolatta sadece OXA-23 tespit edildi. Acinetobacter baumannii izolatlarından bir izolatta OXA-24, 40 izolatta OXA-23 saptandı. Bu çalışma, CRPA (Karbapenem dirençli Pseudomonas aeruginosa) ve CRAB (Karbapenem dirençli Acinetobacter baumannii) izolatlarında karbapenem direncinden OXA-23'ün sorumlu olduğunu göstermektedir.
- MakaleYalnız künye2023Determination of cytotoxic, anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp.
Gıdık, Betül; Kara, Yakup; Akar, Zeynep; Demir, Elif Ayazoglu; Can, Zehra
The study aims to investigate the antioxidant activities, phenolic compounds, acetylcholinesterase enzyme inhibition and cytotoxic effects of two different Artemisia spp. (Artemisia dracunculus L. and Artemisia dracunculoides Pursh) cultivated in Türkiye organically, for the first time. The total phenolic and total flavonoid contents of the plants were determined spectrophotometrically while antioxidant activity DPPH•, CUPRAC, and FRAP was determined using the colorimetric method. And also, acetylcholinesterase in vitro enzyme inhibition activity and anti-cancer activity against human melanoma (VMM917, CRL-3232), lung carcinoma (A549, CCL-185), and normal human fibroblast (hGF, PCS-201-018) cells were studied. Total phenolic (225-324 μg GAE/mL extract) and total flavonoid contents (0.066-0.085 μg QE/mL extract), antioxidant activity Color Scavenging Concentration 50% (DPPH• (CSC50: 1.371-1.655 mg/mL), CUPRAC (0.246-0.344 μM CTEAC) and FRAP (462.133-726.661 μM CTEAC)). A. dracunculus and A. dracunculoides extracts inhibited 40.09 ± 0.65%, and 39.48 ± 3.68% of acetylcholinesterase activity. It was determined that demonstrated the selective effect of A. dracunculus and A. dracunculoides on the cytotoxicity of A549 and hGF cells. According to our results, both tarragon plant species, it may be said that it is not only consumed as food but also used for therapeutic purposes will be beneficial for health.
AtıfOpenAlex1İncele - MakaleAçık Erişim2023Piyasada satılan yoğurtların fizikokimyasal, mikrobiyolojik ve ade-inhibitör aktivitelerinin belirlenmesi
Gürbüz, Zeynep; Şengül, Mustafa; Erkaya, Tuba; Gürmeriç, Hüseyin Ender
Bu çalışmada, Erzurum piyasasında satılan 12 adet farklı ticari yoğurt örneğinin fizikokimyasal, mikrobiyolojik ve reolojik özellikleri ile Anjiyotensin Dönüştürücü Enzim (ADE)-inhibitör aktiviteleri belirlenmiştir. Yoğurtların kurumadde, yağ, protein, serum ayrılması, pH ve viskozite değerleri %11.11-18.05, %1.25-4.70, %3.28-4.66, 0.95-9.00 ml/25g, 3.79-4.61, 7913.0-30425.0 cP aralığında değişmiştir. Mikrobiyolojik analiz sonuçlarına göre yoğurtların L. bulgaricus ve S. thermophilus sayıları ise sırasıyla 5.67-8.32 ve 6.12-8.5 log kob/g aralığında bulunmuştur. Yoğurtların ADE-inhibitör aktivite % ve IC50 analiz sonuçları sırasıyla %55.57-77.90 ve 0.91-1.80 mg/ml arasında değişim göstermiştir. Yoğurt örneklerinin hepsi ADE-inhibitör aktivite göstermiş ve sonuçlar arasında önemli farklar (P <0.05) olduğu ortaya konulmuştur.
- MakaleAçık Erişim2023Some Quality and Microbiological Traits of Tokat Tarhana Obtained from Different Wheat Cultivars Under Various Drying Conditions
Bahar, Bilge; Baltaci, Cemalettin; Gençer, Sevil
This study was carried out to evaluate the variations in some quality traits of Tokat red pepper tarhana samples according to the cultivars and drying techniques. For this aim, five white grained bread wheat cultivars such as Altınöz, Candaş, Gökkan, Şahika, and Yakamoz were used as material. And, tarhana samples were dried under open air, airflow oven and vacuum. The study was conducted with three replications according to the split plot design in random plots. All quality traits showed statistically significant variations for the bread wheat cultivars (C), drying techniques (DT), and DT×C interactions. Thus, airflow oven showed the highest values among the drying techniques for the contents of ash (8.5892%), total titration acidity (27.433%) and salt (6.842%). On the other hand, open air drying technique presented the highest values for moisture (14.556%), pH (4.349) and the density of lactic acid bacteria (LAB) (1.4×104 CFU g-1 for M17 agar, 2.4×104 CFU g-1 for MRS agar. Also, Gökkan cv had the highest percents for all quality traits except LAB density. These findings showed that the most suitable bread wheat cultivar for Tokat red pepper tarhana was Gökkan cv, and the most favorable drying technique was open air drying. In addition, it is understood from the results that wheat cultivar and drying technique which used in tarhana production were essential factors. So, tarhana sector should choose the best wheat cultivar and drying technique to be used in tarhana production for consumer taste and healthy diet. From this study, it is understood that the open air drying is the most sustainable technique in terms of both production and consumption.
AtıfTR Dizin1İncele - MakaleAçık Erişim2023Characterization, Antioxidant and Antimicrobial Activities of Iron Nanoparticles Synthesized Using Firethorn Fruit (Pyracantha coccinea Roemer) Extracts
Düzgün, Azer Özad; Baltaci, Cemalettin; Akar, Bülent; Karakullukçu, Volkan; Karpuz, Omer
The main focus of this study was to explore the biological activity of metal nanoparticles that were green-synthesized from firethorn fruits. Specifically, iron nanoparticles (Fe-NP) were synthesized from extracts obtained from fruits and seeds of the firethorn plant (Pyracantha coccinea) grown on Gumushane University’s campus for landscaping purposes. The antioxidant and antimicrobial properties of both extracts and synthesized iron nanoparticles were evaluated. To characterize the Fe-NPs, FT-IR spectroscopy, scanning electron microscopy (SEM), and X-Ray Diffraction (XRD) analyses were performed. The antioxidant activity of the fruit extracts and Fe-NPs was assessed using various antioxidant activity tests, including ABTS radical scavenging activity, DPPH radical scavenging activity, ferric reducing antioxidant power (FRAP), total phenolic content (TPC), total flavonoid content (TFC), and total antioxidant content (TAC). The results of all antioxidant activity tests indicated that the iron nanoparticles exhibited higher antioxidant activity than the fruit extracts. Moreover, the minimum inhibitory concentrations (MIC) of the fruit extracts and nanoparticles against Gram-negative bacteria (Yersinia pseudotuberculosis ATCC 911, Escherichia coli ATCC 25922, Proteus vulgaris ATCC 13315, and Pseudomonas aeruginosa ATCC 43288) and Gram-positive bacteria (Streptococcus pyogenes ATCC 19615, Staphylococcus aureus ATCC 25923, and Bacillus subtilis ATCC 6633) were determined the using the medium microdilution procedure. Similar to the antioxidant activity findings, the Fe-NPs demonstrated stronger antimicrobial activity compared to the fruit extracts.
AtıfTR Dizin1İncele - MakaleAçık Erişim2022Theoretical Knowledge Difference Between Internet-Based and Digital Storytelling Education About Breast Cancer
Aydin, Aydanur
Aim: Previous research has identified the theoretical knowledge about breast cancer early diagnosis of nursing students and stated that new methods are needed in education. To evaluate the effect of education on the theoretical knowledge of students through internet-based or digital storytelling. Material and Method: Quasi-experimental study with comparison groups and pre- and post-measurements. In the internet-based education group 68 and digital storytelling videos 66 undergraduate nursing students have included in the study. Data for the study were gathered, before education and after eight weeks. The percentages were calculated for every measurement, the test was used for the data whose conformity to normal distribution, and was used to detect the statistical significance of changes between measurements. Results: The increase in knowledge scores was more often statistically significant in internet-based education than in the digital storytelling video. Conclusion: This research shows that it is possible to create changes in teaching breast cancer early diagnosis methods by using the developing technology.
- Derleme MakaleYalnız künye2022Possible Hazards And Risks That Search And Rescue (SAR) Dogs May Face In CBRN Incidents
Cengiz, Sevil
Professional search and rescue (SAR) dogs, which are members of urban search and rescue teams with the help of their higher sense organs with rigorous training, are very helpful in finding buried or missing persons in disasters. In these environments where chaos and disorder prevail, it becomes inevitable for them to face very dangerous and risky situations. As a result of a disaster caused by chemical, biological, radiological and nuclear (CBRN) accidents, dangers such as chemical leaks, pathogenic microorganisms, toxins, vectors, and radioactive and nuclear materials in the environment are among the forgotten or neglected facts that SAR dogs affect as well as affect humanity. Working with little or no personal protective equipment during search and rescue interventions makes them completely vulnerable to these hazards. In the limited resources in the literature on CBRN risks and dangers that search and rescue dogs working in disaster areas may encounter, SAR dogs are exposed to many chemicals and toxic agents during these studies, as well as biological hazards such as protozoal or coliform bacterial organisms, and radiological hazards such as the risk of ingesting radioactive materials and breathing dust. their arrival has been determined. With this study, it was aimed to emphasize the dangers faced by SAR dogs and to emphasize what has been done and what should be done to reduce the possible risks. As a result, necessary precautions should be taken to prevent and/or reduce these possible exposures of SAR dogs, and further studies should be carried out for appropriate standard procedures for appropriate rehabilitation and decontamination.
- MakaleAçık Erişim2022Determination of LC-MS/MS phenolic profile, antioxidant and α-glucosidase enzyme inhibition activities of Linum mucronatum Bertol. subsp. armenum (Bordz.) P.H.Davis
Akar, Zeynep; Kılıç, Fatma
Plants include compounds having high antioxidant activity such as flavonoids, phenolics, and carotenoids. Antioxidant defense mechanisms play an important role in the prevention and treatment of oxidative stress diseases in humans. In the present study, the flower and leaf parts of Linum mucronatum subsp. armenum were extracted in five different solvents. The antioxidant activities of the extracts were determine using six antioxidant activity determination assays (Iron (III) reducing/antioxidant power (FRAP), DPPH radical scavenging activity, copper (II) reducing antioxidant activity (CUPRAC), ABTS radical scavenging capacity, total flavonoid content and total phenolic content). While, the methanol extract showed the highest activity for the flower part, ethanol extracts of leaf part showed the highest antioxidant activity in the DPPH, FRAP and CUPRAC tests. The highest activity values in both flower and leaf parts was measured in acetone extract with SC50=0.287 mg/mL and (SC50=0.163 mg/mL in ABTS test, respectively. Lowest activity values of solvent extracts were measured in hexane extracts in all tests. Phenolic compounds of the plant were identified using LC-MS/MS. These phenolics are kaempferol, vanillin, protecatechuic acid, caffeic acid, p-coumaric acid, p-OH benzoic acid, salicylic acid, quercetin and rutin. The leaf and flower parts have α-glucosidase enzyme inhibitor effect. It was determined that the leaf part of the plant (IC50=4.533 mg/mL) have higher enzyme inhibition than in the flower (IC50=6.096 mg/mL). As a result, it was determined that the plant showed the biological activity. The results will contribute to the studies on the biological activity of the other plant.
AtıfOpenAlex2TR Dizin1İncele - MakaleYalnız künye2022Determination of the Factors Affecting the COVID-19 Knowledge Levels and the Status of Being Diagnosed with COVID-19 in Healthcare Employees Struggling with Pandemic
Sahin, Ceyda Uzun; Kulakaç, Nurşen
The present study was conducted to determine of the factors affecting the COVID-19 knowledge levels and the status of being diagnosed with COVID-19 in healthcare employees struggling with the pandemic. This study, which was planned in cross-sectional and descriptive-correlational design. The healthcare employees working in hospitals in 6 city centers in the Black Sea Region, which has the highest number of COVID-19 cases in Turkey, were included in the study (n=385). It was determined in the present study that 33.85±9.11 (min.20, max.60), 57.9% of the participants were female, 43.4% were nurses, and 47% were infected with coronavirus. It was found that the factors that affected the coronavirus knowledge scores of health employees significantly were being diagnosed with COVID-19, presence of chronic diseases, receiving psychological support, female gender, and fighting COVID-19 in the front line. The risk factors for being infected with coronavirus disease were found to be the lack of personal protective equipment, unit worked at, and N95 mask replacement time (p<0.05). As a result of this study, ıt is recommended to provide evidence-based trainings to prevent transmission of future outbreaks and to support coping strengths since infection in healthcare employees is high.
- MakaleAçık Erişim2020Analysis of The Dynamics of The Classical Epidemic Model with Beta Distributed Random Components
Merdan, Mehmet; Bekiryazıcı, Zafer; Kesemen, Tülay
In this study, the classical epidemic model of Kermack and McKendrick is analyzed with beta distributed random components. A random analysis is done for the deterministic epidemic model by transforming the parameters and initial values of the system to random variables with beta distribution. The approximations for the expectations of the model variables are compared with the deterministic results to comment on the randomness of the cases with random parameters and random initial values. Results for some numerical characteristics of these two cases are also given to investigate the accuracy of the approximations for the expected values.
AtıfOpenAlex1TR Dizin1İncele