Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(62)
- Merdan, Mehmet(58)
- Duran, Celal(50)
- Ozdes, Duygu(47)
- Kaygusuz, Abdullah(43)
- Ashyralyyev, Charyyar(38)
- Karsli, Orhan(33)
- Öztürk, Serkan(32)
- Araz, Onur(31)
- Demir, Selim(29)
- Kulakaç, Nurşen(29)
- Dokuz, Abdurrahman(28)
- Arslan, Mehmet(27)
- Baltacı, Cemalettin(27)
- Maden, Nafiz(27)
- Sipahi, Ferkan(27)
- Topal, Fevzi(27)
- Turan, Ibrahim(27)
- Kandemir, Raif(25)
- Kurt, Kemal(24)
- Ozturk, Samet(24)
- Peker, Iskender(24)
- Vural, Alaaddin(24)
- Reis, Hatice Catal(23)
- Yücel, Cem(23)
- Aydin, Faruk(22)
- Baltaci, Cemalettin(22)
- Gücer, Mehmet Ali(22)
- Günen, Mehmet Akif(22)
- Kankal, Murat(22)
- Topal, Meryem(22)
- Karimullah, Suud Sarim(21)
- Uysal, Ibrahim(20)
- Kurnaz, Muammer(19)
- Tuncer, Metin(19)
- Yolcu, Halil(19)
- Çelik, Necati(19)
- Ürkek, Bayram(19)
- Şan, Murat(19)
- Aliyazicioglu, Yuksel(18)
Yayınlar
- MakaleAçık Erişim2016Scopus SJRQ2Kinetic characterization of GES-22 β-lactamase harboring the M169L clinical mutation
Saral, Aysegul; Leonard, David A; Duzgun, Azer Ozad; Cicek, Aysegul Copur; June, Cynthia M; Sandalli, Cemal
The class A β-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a structure that is known to have major effects on substrate selectivity in class A β-lactamases, we expressed, purified and kinetically characterized this novel variant. Our results show that compared with GES-116×His, GES-226×His displays more efficient hydrolysis of penicillins, and aztreonam, but a loss of efficiency against ceftazidime. In addition, the M169L substitution confers on GES-22 more efficient hydrolysis of the mechanistic inhibitors clavulanic acid and sulbactam. These effects are highly similar to other mutations at the homologous position in other class A β-lactamases, suggesting that this methionine has a key structural role in aligning active site residues and in substrate selectivity across the class.
AtıfScopus5WoS4OpenAlex5
İncele - MakaleAçık Erişim2016Scopus SJRQ2Determining the Effect of Seasonal Variation in Spruce (Picea orientalis L.) Wood Treated with Various Impregnations on Combustion Resistance
Yasar, Ş. Şadiye; Fidan, M. Said; Yaşar, Mehmet; Atar, Musa; Alkan, Elif
Prepared test specimens were surface treated and coated with synthetic and water-based outdoor varnishes after being chemically impregnated. The test specimens were left outdoors to determine the effects of impregnation and treatment on the wood during each of the four seasons. Caucasian spruce (Picea orientalis L.) test specimens were prepared and combustion analyses were performed. As a result of the combustion test, weight loss results, as compared with the control, were 89% lower in the spring specimens, 90% lower with impregnation, and 90% lower with the synthetic varnish coating. Furthermore, the O2 amount during combustion was found to be the highest in combustion with a flame source in the winter specimens (21%). The CO2 amount was the highest in combustion without a flame source for full-year specimens (20%). The CO amount was the highest in combustion without a flame source of full-year specimens (31,787 ppm), and the NO amount was the highest during glowing of full-year specimens (55 ppm). Final results showed impregnation with Tanalith-E and water-based varnish coating to be the most effective fire protective treatments.
AtıfScopus5WoS5OpenAlex3İncele - MakaleYalnız künye2016Scopus SJRQ2Influence of CrN Coating on Electrochemical Behavior of Plasma Nitrided Pure Titanium in Bio-simulated Environment
Çelik, Ilhan
Titanium and its alloys are widely used as materials for bio-medical applications, such as implants. However, ions of the alloy can release to the body region and spread into the blood circulation. In this study, plasma nitriding and CrN coating techniques are used in order to overcome the problem of ion release. The objective of this study was to investigate the effects of plasma nitrided pure titanium on the structural properties and corrosion behaviors before and after CrN coating in Ringer's solution at 37 °C. The structural properties were investigated using Scanning Electron Microscopy (SEM) and X-ray diffraction (XRD). A diffusion layer and a compound layer composed of δ-TiN and ε-Ti2N phases were observed on the surface of nitrided pure titanium. Corrosion tests were made for the determination of electrochemical properties with the help of Potentiostat/Galvanostat device. The results show that corrosion behaviors of untreated and treated samples have similar characteristic.
AtıfScopus19WoS15OpenAlex19İncele - MakaleAçık Erişim2016Scopus SJRQ3Investigation of structural and tribological properties of duplex surface treated pure titanium
Çelik, I.; Karakan, M.
Commercial pure titanium (CP-Ti) is used in many engineering fields because of its superior properties such as excellent corrosion resistance, high strength/weight ratio, and biocompatibility. However, it is not available at the desired rate, since the CP-Ti has poor wear resistance. For this reason, many surface treatments have been applied to improve the poor tribological properties of the CP-Ti. In this study, duplex surface treatments, which are the combination of treatments of electroless Ni-B coating and plasma nitriding, were applied on the surfaces of the CP-Ti. Structural properties of the different surfaces of the treated materials were investigated using scanning electron microscopy (SEM) and X-ray diffraction (XRD). Microhardness measurements were made for the determination of mechanical properties and the pin-on-disk wear tests were made to determine the tribological properties. It was observed that poor wear resistance of the CP-Ti was improved with duplex surface treatments. The results showed that surface hardness, friction coefficient, and surface roughness of coated samples were better than of uncoated CP-Ti.
AtıfScopus7WoS5OpenAlex6İncele - MakaleAçık Erişim2016Scopus SJRQ3Determination of stand structure in even-aged oriental beech forests in Turkey; [Determinación de la estructura de rodales de Fagus orientalis coetáneos en Turquía]
Kahriman, Aydın; Altun, Lokman; Güvendi, Engin
This study aimed at developing a stand yield model for even-aged and pure Oriental beech (Fagus orientalis) stands in Sinop Province, located in the north of Turkey. The data used in this study were obtained from 238 sample plots. The sample plots are 24–131 years of stand age range, 19.0–35.9 m of site index range, and 2.2–10.8 of stand density range (relative density index). With the generated equation systems, stand age, site index and density of the three main factors in Oriental beech stands, including the effects of individual, dual and triple factor interactions on the stands were numerically determined. As for even-aged Oriental beech stands, the main stand volume values increase depending on age, site index and density. The number of stems per hectare decreases as the stand grows older, and site index rises; the number, however, increases in parallel with stand density. The current annual volume increment reaches a peak at 30-35 years at all site index groups and density levels, and begins to fall afterwards. Mean annual volume increment peaks up at 65-75 years at all site index classes and density levels, before beginning to decline. The results were in arrangement with the acknowledged growth rules. Stand yield models were assessed as Density-Variable Yield Table used for estimation of the remaining, removal and total stands.
AtıfScopus4WoS3OpenAlex1İncele - MakaleAçık Erişim2016Scopus SJRQ2Diversity and ecology of benthic algae in Karagöl Lake, Karagöl-Sahara National Park (Şavşat, Artvin, Turkey)
Akar, Bülent; Şahın, Bülent
Benthic algal flora of Karagöl Lake, its seasonal variation, and the physical and chemical parameters of the water were studied between October 2008 and September 2010. The algal flora consisted of 112 taxa belonging to the divisions Charophyta (41), Chlorophyta (33), Cyanobacteria (18), Euglenozoa (17), Miozoa (2), and Ochrophyta (1). Six desmid taxa found in this research are new records for the freshwater algal flora of Turkey. The qualitative dominance of benthic taxa typical of slightly alkaline and mesotrophic ecosystems was observed. The qualitative and seasonal variations in epipelic taxa analyzed were dependent on the physicochemical characteristics of the water. Water quality was analyzed on the basis of benthic taxa, which are bioindicators. The physicochemical properties of the water are suitable for the development of a rich algal flora (especially desmids). According to the benthic algal composition and indicator species, it is estimated that Karagöl Lake has mesotrophic lake characteristics. This is the first study of benthic algal flora of Karagöl Lake and marks a significant contribution to the knowledge of Karagöl-Sahara National Park’s aquatic biodiversity.
AtıfScopus5WoS3OpenAlex3TR Dizin1
İncele - BildiriYalnız künye20163D shoreline extraction using orthophoto and LiDAR data
Bayram, Bulent; Demir, Nusret; Ogurlu, Mustafa; Reis, Hatice Catal; Seker, Dursun Zafer
Shorelines are complex ecosystems and vital socio-economic environments. They may change rapidly due to both natural and human-induced effects. Determination of movements along the shoreline and monitoring of the changes are indispensable for many purposes such as coastline management, agriculture, decision support systems etc. Thus, rapid, up-to-date and accurate information are required to monitor the shorelines. In this study, the Kestel Dam Lake has been selected for evaluation and testing of the methods which will be used for the research project, about shoreline extraction with use of UAV-Based LIDAR data in the region of Terkos-Istanbul, which supported by TUBITAK (The Scientific and Technological Research Council of Turkey) with project nr. 115-718. Kestel Dam is located on the river of Kestel that is constructed for the irrigation purposes, built between 1983 and 1988. Irrigation capacity of dam is about 4077 ha of agricultural areas. The used dataset is LIDAR data which is provided by HGK (Turkish General Command of Mapping). In this study, two different methods are applied with use of LIDAR data, acquired in 2013. One method is mean-shift segmentation and the other is Particle Swarm Optimization Analysis (PSO). The results are both compared with manually created reference vector dataset which is created using orthoimage dataset. The results shows that the developed methods have potential to give success in the research project which will be performed in the region of Terkos which is the study area of the project.
AtıfScopus4İncele - MakaleAçık Erişim2016Scopus SJRQ3Existence and uniqueness theorems for sequential linear conformable fractional differential equations
Gökdoğan, Ahmet; Ünal, Emrah; Çelik, Ercan
Recently, a new definition of fractional derivative called as the conformable fractional derivative which based on limits introduced by Khalil et al (2014). Later, Abdeljawad (2015) improved these definitions and gave the basic concepts in this new fractional calculus. In this paper, we generalize Abel's formula and Wronskian determinant definition and establish existence and uniqueness theorems for sequential linear conformable fractional differential equations.
AtıfScopus27WoS26OpenAlex40İncele - MakaleYalnız künye2016Scopus SJRQ1U–Pb zircon chronology and petrogenesis of Carboniferous plutons in the northern part of the Eastern Pontides, NE Turkey: Constraints for Paleozoic magmatism and geodynamic evolution
Kaygusuz, Abdullah; Arslan, Mehmet; Sipahi, Ferkan; Temizel, İrfan
Numerous intrusive rocks of varying ages and compositions exist in the Paleozoic to Tertiary periods in the Eastern Pontides. Carboniferous intrusive rocks are commonly observed in the southern part of the Eastern Pontides. The nature of the rocks in the northern part of the region has not been determined because of Upper Cretaceous and Tertiary volcano-sedimentary units. Whole-rock geochemical, isotopic and geochronological data obtained from five different mapped granitoid bodies located in the northern part of the Eastern Pontides allow for the proper reconstruction of Carboniferous magmatism and the geodynamic evolution of the region. According to laser ablation ICP-MS U–Pb zircon dating, the Özdil, Soğuksu, Seslikaya, Kızılağaç and Şahmetlik plutons have similar 206Pb/238U vs. 207Pb/235U concordia ages of 340.7 ± 1.8 Ma and 323.1 ± 1.5 Ma, 348.4 ± 1.6 Ma, 335.4 ± 1.4 Ma, 337.2 ± 0.6 Ma and 334.5 ± 1.4 Ma, respectively. The aluminium saturation index (ASI) values of all of the samples from the plutons are between 1.0 and 1.32, which indicate peraluminous melt compositions. The plutons have SiO2 contents between 59 and 79 wt.% and show low- to high-K calc-alkaline characteristics. The plutons are enriched in large-ion lithophile and light rare earth elements and are depleted in high-field strength elements. Chondrite-normalized rare earth element patterns are characterized by concave-upward shapes and pronounced negative Eu anomalies, with LaCN/YbCN = 1.9–46.8 and EuCN/Eu* = 0.19–1.76. The studied plutons show considerable variations in 87Sr/86Sr(i) (0.70255 to 0.71006) and εNd(i) values (− 4.8 to − 7.1), as well as Nd model ages (1.15 to 2.47 Ga). The Pb-isotopic ratios are 206Pb/204Pb = 17.11–18.60, 207Pb/204Pb = 15.58–15.64 and 208Pb/204Pb = 36.95–38.62. The crystallization temperatures of the melts range from 676 to 993 °C, as determined by zircon and apatite saturation thermometry. These data suggest that the Carboniferous granitic magmas were produced by the partial melting of meta-mafic to meta-felsic lower crustal source rocks, with minor contributions from the mantle. Collectively, these rocks represent a late stage of Hercynian magmatism in the northern part of the Eastern Pontides.
AtıfScopus90WoS84OpenAlex97İncele - MakaleYayıncıda açık erişim2016Scopus SJRQ1Modeling deformation modulus of a stratified sedimentary rock mass using neural network, fuzzy inference and genetic programming
Alemdag, S.; Gurocak, Z.; Cevik, A.; Cabalar, A.F.; Gokceoglu, C.
This paper investigates a series of experimental results and numerical simulations employed to estimate the deformation modulus of a stratified rock mass. The deformation modulus of rock mass has a significant importance for some applications in engineering geology and geotechnical projects including foundation, slope, and tunnel designs. Deformation modulus of a rock mass can be determined using large scale in-situ tests. This large scale sophisticated in-situ testing equipments are sometimes difficult to install, plus time consuming to be employed in the field. Therefore, this study aims to estimate indirectly the deformation modulus values via empirical methods such as the neural network, neuro fuzzy and genetic programming approaches. A series of analyses have been developed for correlating various relationships between the deformation modulus of rock mass, rock mass rating, rock quality designation, uniaxial compressive strength, and elasticity modulus of intact rock parameters. The performance capacities of proposed models are assessed and found as quite satisfactory. At the completion of a comparative study on the accuracy of models, in the results, it is seen that overall genetic programming models yielded more precise results than neural network and neuro fuzzy models.
AtıfScopus113WoS110OpenAlex108İncele - MakaleYalnız künye2016Scopus SJRQ3Students understanding of mathematics using from prototypical examples: Analyze in linear algebra
Aydin, Sinan; Akkan, Yaşar
Mathematical objects are ʼnatural objects’ for the practical mind. Definitions and theories can only describe them, not create or construct them. A mathematical term is interpreted through its denotation as representing a collection of particular objects for the theoretical mind. So, theoretical and practical modes of thinking differ in the manner in which they constitute the meanings of words. Thinking in terms of prototypical examples, rather than definitions, became an obstacle to our students’ understanding the notion of linear transformation. In the course, linear transformations were defined as transformations of vector spaces which conserve linear combinations. The obstacle was revealed in the students’ attempts ‘linear extension problem’: given a transformation of a basis, to construct a linear transformation with those values on the basis. In the experimental course, the problem was not formulated in such general terms. It was restricted to two dimensions, and the students were not asked to ‘linearly extend a transformation from a basis to the whole plane’ but to assume the existence of such an extension and find some missing information about it. In this study we are discussing students understanding of mathematical concepts by means of linear transformation in linear algebra.
- MakaleAçık Erişim2016Scopus SJRQ2Effect of Turkish pollen and propolis extracts on caspase-3 activity in myeloid cancer cell lines
Uçar, Meltem; Değer, Orhan; Gerigelmez, Asuman Yiğit; Cengiz, Sevil; Barlak, Yaşam; Ovalı, Ercüment
Purpose: To investigate the apoptosis-inducing capacity of dimethyl sulfoxide (DMSO) extracts of bee pollen and propolis in HL-60 Myeloid Cancer Cell Lines. Methods: DMSO extracts of pollen and propolis were incubated separately with HL-60 cells, and caspase-3 activity evaluated. In order to determine the cell cycle characteristics of HL-60 cells with and without extracts of pollen and propolis, the cells were analysed using flow cytometry. Results: The DMSO extract of propolis (0.5 mg/mL) increased apoptosis from undetectable levels to 60.1%, while maintaining cell viability. The DMSO extract of pollen (2 mg/ml) increased apoptosis from undetectable levels to 52.2% while decreasing cell viability by 62%. Caspase-3 activity in HL-60 cells incubated with DMSO extracts of pollen and propolis were 3.6-to 12-fold higher than in controls. Conclusion: Turkish pollen and propolis individually increase apoptosis and the activity of caspase-3 in HL-60 cells. This finding indicates that bee products may have beneficial effects in the treatment of cancer.
AtıfScopus12WoS10OpenAlex12İncele - BildiriYalnız künye2016An assessment on the recent seismicity in the north anatolian fault zone, Turkey
Özturk, S.; Sari, M.
A statistical assessment of recent seismicity in the North Anatolian Fault Zone, Turkey, is made by using seismotectonic b-value and precursory seismic quiescence Z-value. The catalogue including 28,420 earthquakes between 1970 and 2016 is used. Using the Reasenberg declustering process and the earthquakes with MD≥2.7, 51.4% of the events are removed and so, 13,815 events are used for a quantitative evaluation of seismic quiescence in the NAFZ in the beginning of 2016. Completeness magnitude is estimated as 2.7. Resulting values show that significant anomalies are observed in both band Z-values in some parts of the NAFZ. The larger b-values are calculated in Silivri, Black Sea, Izmit and Düzce whereas the smaller b-values are estimated in the western, the eastern and the middle parts of the NAFZ, covering Gulf of Saros, Gelibolu (Çanakkale), Ismetpasa segment, Bingöl, Erzincan, Amasya and Çankiri. Several quiescence regions in and around Tekirdag, Gulf of Saros, Istanbul, Marmara and Black Sea, Izmit, Düzce fault, Mudurnu, Çankiri, Amasya are observed. Consequently, the same regions including Gulf of Saros, Çankiri and Amasya where the smallest b-values and the largest Z-values are obtained may give important evidences to reveal the future earthquake potential in the North Anatolian Fault Zone.
- MakaleYalnız künye2016Scopus SJRQ3Determination of Pomological and Morphological Characteristics and Chemical Compositions of Local Apple Varieties Grown in Gumushane, Turkey; [Bestimmung der pomologischen und morphologischen Eigenschaften sowie der chemischen Zusammensetzung lokaler Apfelsorten aus dem Gebiet Gumushane, Türkei]
Kalkisim, Ozgun; Ozdes, Duygu; Okcu, Zuhal; Karabulut, Besim; Senturk, Hasan Basri
The present study was conducted in order to determine the pomological and morphological characteristics and chemical compositions of some local apple varieties grown in Gumushane. As a result of field work in Gumushane province, sixteen different apples, which are Summer Apple, English apple, Green Belly, Black Belly and Yellow Belly Apples, Amasya Marble, Bey Apple, Chest Apple, Mahsusa, Arabian Girl, Willow Apple, Tavşanbaşı, Yellow Hıdır, Local Marble, Bride Apple, and Fatty Apple were collected in order to analyze. The average results of pomological and morphological properties and chemical compositions were obtained as following: fruit mass; 127.36 g, fruit width; 65.23 mm, fruit length; 57.30 mm, fruit stalk thickness; 2.17 mm, fruit stalk length; 17.63 mm, stalk pit depth; 12.75 mm, flower pit depth; 10.29 mm, fruit firmness; 13.79 kg/cm2, seed house width; 15.89 mm, seed house length; 17.39 mm, number of seeds; 4.3, water soluble dry matter content; 14.53 %, ash content; 1.11 %, pH; 3.8, titratable acidity; 0.69 g/L, water content; 83.8 %, reducing sugar; 5.04 g/100 g, sucrose; 2.25 g/100 g, and the amount of total sugars; 7.29 g/100. The fruit peel color was determined by considering the light transmittance (L). The average L values were ranged between 112.06 and 66.32. On the other hand among the mineral elements, potassium and manganese amounts were determined as the highest and the lowest, respectively.
AtıfScopus13WoS10OpenAlex13İncele - MakaleYalnız künye2016Scopus SJRQ3Relationships Among some Pears Genotypes (Pyrus Communis L.) Based on ISSR and RAPD Analysis; [Bestimmung der genetischen Verwandtschaft bei Birnen mit Hilfe der ISSR und RAPD Methoden]
Kalkışım, Ozgun; Okcu, Melih; Okcu, Zuhal; Karabulut, Besim; Yildirim, Nalan; Agar, Guleray
Thirty one pears genotypes from east blacksea region were evaluated for genetic relationships by using Randomly Amplified Polymorphic DNA (RAPD) and ISSR (Inter-Simple Sequence Repeats) markers from total 70 RAPD and ISSR primer investigated, 22 could amplify clearly and consistently. Cluster analysis of the pears genotypes was performed based on data from polymorphic bands RAPD and ISSR by using Jaccard’s similarity coefficient and the Unweighted pair-group method with arithmetic average (UPGMA) clustering method. The 31 pear genotypes were classified into two major groups. Cluster A was divided into 2 subclusters: Gumushane pears and Trabzon pears. Cluster B consisted of Artvin pears. The similarity matrix values ranged between 0.105 and 0.968.
AtıfScopus10WoS8OpenAlex13İncele - MakaleAçık Erişim2016Scopus SJRQ4On the fractional Riccati differential equation
Khaniyev, Tahir; Merdan, Mehmet
In this paper, We tried to find an analytical solution of nonlinear Riccati conformable fractional differential equation. Fractional derivatives are described in the conformable derivative. The behavior of the solutions and the effects of different values of fractional order α are presented graphically and table. The results obtained by the CFD(conformable fractional derivative) are compared with homotopy perturbation method(HPM), fractional variational iteration method(FVIM).
AtıfScopus3OpenAlex3İncele - BildiriAçık Erişim2016The impossibility of producing I-131 from its daughter Xe-131 by photonuclear reactions
Bayram, Tuncay; Akkoyun, Serkan; Çelik, Necati; Haciislamoǧlu, Emel; Uruk, Serhat; Şentürk, Şevki; Ristic, G
131I is one of the radioisotopes in nuclear medicine procedures for diagnostic and treatment purposes. It decays to 131Xe by emitting beta particles. In this study, we have investigated the reproduction possibility of 131I from 131Xe by using different reactions, including a photonuclear reaction step. We have used TALYS computer program for calculating cross-sections of the reactions. It was seen that it was not an easy task to reproduce 131I from its decay product 131Xe because of low reaction cross-section values. According to the results, we have seen that the calculations are in harmony with the TENDL 2014 database.
- MakaleAçık Erişim2016Scopus SJRQ3Additional operation learning process to the mild intellectual disabilities students by means of virtual manipulatives: A multiple case study
Öztürk, Mesut; Akkan, Yaşar; Büyüksevindik, Baki; Kaplan, Abdullah
It is frequently emphasized that technology integration to the education of the students have intellectual disabilities has great importance. The researches performed show that using virtual manipulatives consist positive effects on learning mathematics on the students have intellectual disabilities. This study was done to investigate the addition operation learning process of the students have intellectual disabilities. Two students have mild intellectual disabilities and are 14 and 17 years old participated to this research conducted by means of multiple case study is one of the qualitative research designs. In this study was realized during five schedules data were collected through interviews, observations and documents. Content analysis were used for data analysis. At the end of the analysis, three categories of findings on "Learning of the addition operation", "Opinions on the use of computer and virtual manipulatives" and "Individual differences", were structured.
AtıfScopus2WoS3OpenAlex5İncele - MakaleAçık Erişim2016Scopus SJRQ29,10-Dibromo-N-aryl-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-diones: Synthesis and Investigation of Their Effects on Carbonic Anhydrase Isozymes I, II, IX, and XII
Göksu, Haydar; Topal, Meryem; Keskin, Ali; Gültekin, Mehmet S.; Çelik, Murat; Gülçin, Ilhami; Tanc, Muhammet; Supuran, Claudiu T.
N-substituted maleimides were synthesized from maleic anhydride and primary amines. 1,4-Dibromo-dibenzo[e,h]bicyclo-[2,2,2]octane-2,3-dicarboximide derivatives (4a-f) were prepared by the [4+2] cycloaddition reaction of dibromoanthracenes with the N-substituted maleimide derivatives. The carbonic anhydrase (CA, EC 4.2.1.1) inhibitory effects of the new derivatives were assayed against the human (h) isozymes hCA I, II, IX, and XII. All tested bicyclo dicarboximide derivatives exhibited excellent inhibitory effects in the nanomolar range, with Ki values in the range of 117.73-232.87 nM against hCA I and of 69.74-111.51 nM against hCA II, whereas they were low micromolar inhibitors against hCA IX and XII. A series of 9,10-dibromo-N-aryl-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-diones (4a-f) were synthesized from N-substituted maleimide derivatives and 9,10-dibromoanthracene. Compounds 4a-f were assayed against human carbonic anhydrases (hCA) IX and XII, which are the two tumor-associated isozymes, and hCA I and II, which represent the most common off-targets for the development of selective anticancer CA inhibitors.
AtıfScopus36WoS35OpenAlex35İncele - MakaleAçık Erişim2016Scopus SJRQ2Assessing the effects of long-term recreational activities on landscape changes in Abant Natural Park, Turkey
Çakir, Günay; Müderrisoğlu, Haldun; Kaya, Latif Gürkan
Natural, protected areas offer many possibilities for recreation in rural areas such as camping, one of the most popular activities. The system established for protected areas in Turkey aims to provide a foundation for conserving areas for recreation. One such area, Abant Natural Park, is convenient for visits from Turkey’s two most populated metropolitan areas, Istanbul and Ankara. It also attracts tourists from other regions and countries. The aim of the present study was to evaluate the vegetation loss and land cover changes due to picnic/camping, transhumance, and construction over 40 years (1966–2004) in the park using data on visitor numbers, vegetation patches, corridors and connectivity. For evaluating landscape variables, remote sensing data and aerial photos were used. When aerial photos were imported into the ERDAS Imagine program, ground control points identified, and individual images orthorectified, land degradation was not found in the use of camping areas. Moreover, manmade areas (road, car park and hotel) observably increased, thus decreasing the forest lands. The findings show that the land use types that have had the greatest ecological impact are transhumance and construction of hotels, which also require infrastructure development. The intensity of the ecological effects mandates precautions to lessen the impacts and the need for continuing assessment to ensure sustainable use of the area.
AtıfScopus19WoS16OpenAlex19İncele