Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(62)
- Merdan, Mehmet(58)
- Duran, Celal(50)
- Ozdes, Duygu(47)
- Kaygusuz, Abdullah(43)
- Ashyralyyev, Charyyar(38)
- Karsli, Orhan(33)
- Öztürk, Serkan(32)
- Araz, Onur(31)
- Demir, Selim(29)
- Kulakaç, Nurşen(29)
- Dokuz, Abdurrahman(28)
- Arslan, Mehmet(27)
- Baltacı, Cemalettin(27)
- Maden, Nafiz(27)
- Sipahi, Ferkan(27)
- Topal, Fevzi(27)
- Turan, Ibrahim(27)
- Kandemir, Raif(25)
- Kurt, Kemal(24)
- Ozturk, Samet(24)
- Peker, Iskender(24)
- Vural, Alaaddin(24)
- Reis, Hatice Catal(23)
- Yücel, Cem(23)
- Aydin, Faruk(22)
- Baltaci, Cemalettin(22)
- Gücer, Mehmet Ali(22)
- Günen, Mehmet Akif(22)
- Kankal, Murat(22)
- Topal, Meryem(22)
- Karimullah, Suud Sarim(21)
- Uysal, Ibrahim(20)
- Kurnaz, Muammer(19)
- Tuncer, Metin(19)
- Yolcu, Halil(19)
- Çelik, Necati(19)
- Ürkek, Bayram(19)
- Şan, Murat(19)
- Aliyazicioglu, Yuksel(18)
Yayınlar
- MakaleYalnız künye2017Scopus SJRQ1Petrogenesis of ultramafic rocks from the eastern Orhaneli ophiolite, NW Turkey: Hints on the initiation and evolution of melt-peridotite interaction processes within a heterogeneously depleted mantle section
Uysal, Ibrahim; Dokuz, Abdurrahman; Kapsiotis, Argyrios; Saka, Samet; Karsli, Orhan; Kaliwoda, Melanie; Mueller, Dirk
The eastern Orhaneli ophiolite in NW Anatolia (Turkey) consists of voluminous dunite and minor harzburgite intruded by clinopyroxenite veins. Harzburgite contains spinel of low Cr# [100 x Cr/(Cr + Al) = 40-45] and diopside of low Al2O3 and TiO2 contents, whereas dunite contains spinel of higher Cr# (62-82) and diopside (blebs) (even more) depleted in Al2O3 and TiO2 (than harzburgite). The concentrations of Heavy Rare Earth Elements (HREE) in harzburgite are consistent with derivation of this type of peridotite from 19% dry melting of a fertile mantle protolith at a MOR regime. Dunites have lower concentrations of HREE than harzburgite implying that dunites were generated by higher degrees (> 30%) of (cumulative) melting of the same protolith. Furthermore, the characteristic U-shapes of the chondrite-normalized REE-patterns of dunites indicate the involvement of hydrous melt-peridotite interaction processes in their genesis. Nevertheless, a set of mosaic-in texture dunite samples contain olivine that has lower Fo# [100 x Mg/(Mg + Fe2+)] and NiO contents than olivine in harzburgite. These dunites are probably of cumulate origin as it is also indicated by their enrichment in Pt and Pd (<= 17.92 ppb). Micro-textural and Re-Os isotopic data support that clinopyroxenite intrusions do not have a pure magmatic origin and their formation was partly controlled by metasomatic processes. Overall data indicate that the eastern Orhaneli ultramafic rocks have a complex petrological history including various stages of partial melting, metasomatism and magmatism in an evolving from MOR to SSZ geotectonic setting.
AtıfScopus17WoS14OpenAlex15
İncele - MakaleAçık Erişim2017Scopus SJRQ4Synthesis of some natural sulphonamide derivatives as carbonic anhydrase inhibitors
Gokcen, Taner; Al, Melike; Topal, Meryem; Gulcin, Ilhami; Ozturk, Turan; Goren, Ahmet C.
Carbonic anhydrase inhibitor; sulphonamides; p-hydroxybenzoic acid; 3,4,5-trihydroxybenzoic acid (gallic acid).Carbonic anhydrase inhibitors are both in clinical use as antiglaucoma, diuretics, antiepileptics and management of altitude sickness, and under investigation as anticancer, anticonvulsant and antiobesity agents. Sulphonamides have been known for decades as carbonic anhydrase inhibitors and are in clinical use. Sulphonamide derivatives of p-hydroxybenzoic acid and 3,4,5-trihydroxybenzoic acid (gallic acid) were synthesized and their inhibition values over hCA I and hCA II isozymes, purified from human erythrocyte cells by Sepharose-4B-L-tyrosine-sulphanilamide, were determined. Compounds synthesized showed efficient carbonic anhydrase inhibition activity at low nM levels.
AtıfScopus27WoS24OpenAlex27İncele - MakaleAçık Erişim2017Scopus SJRQ3Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands
Ayvaz, Melekcol; Turan, Ibrahim; Dural, Bayram; Demir, Selim; Karaoglu, Kaan; Aliyazicioglu, Yuksel; Serbest, Kerim
Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) transition metal complexes of 2-hydroxy-5-[(E)-(4-phenyl) diazenyl] benzaldehyde oxime and 2-hydroxy-5-[(E)-(4-nitrophenyl) diazenyl] benzaldehyde oxime ligands were synthesized and characterized through NMR, IR, ESI mass, and UV analysis. DNA binding abilities of the complexes were revealed using a UV-Vis spectrophotometer with the absorption titration and competitive binding techniques. Hydrolytic and oxidative DNA cleavage activities under different conditions were also proved. Topoisomerase I inhibition efficiencies and in vitro free radical scavenging activities of all complexes were examined. Finally, the selective cytotoxic potentials of all complexes were evaluated in human colon cancer, normal colon, and fibroblast cell lines using the water-soluble tetrazolium salt (WST-1) assay. The complexes had the ability to intercalate into stacked base pairs of DNA and topoisomerase I activity was reasonably inhibited in their presence in 0.4 mM concentrations. The abilities for scavenging of DPPH and hydroxyl radicals were found to be higher than those of known standard antioxidants (ascorbic acid, butylated hydroxyanisole, and mannitol). The results obtained from the cytotoxicity experiments are especially promising for further research, which must be carried out for the evaluation of the studied complexes as anticancer drugs.
AtıfScopus8WoS8OpenAlex8TR Dizin2
İncele - MakaleAçık Erişim2017Scopus SJRQ2Accumulation of phenolics in natural and micropropagated plantlets of Thymus pseudopulegioides Klokov & Des.-Shost. with their antioxidant potentials
Günaydin, Mustafa; Laghari, Abdul Hafeez; Bektas, Ersan; Sökmen, Munevver; Sökmen, Atalay
Thymus pseudopulegioides plantlets were propagated in vitro via direct organogenesis by using Murashige and Skoog (MS) media containing kinetin, thidiazuron, and 6-benzyladenine (BA) individually. Methanol extracts obtained both from plantlets and wild plants were analyzed for their total phenolics and flavonoid contents, then quantified by HPLC. The highest total phenolic (8.83 mg/g as gallic acid equivalent) and total flavonoid (0.92 mg/mL as rutin equivalent) values were from the MS media supplemented with 1.0 mg/L kinetin and 0.5 mg/L BA, respectively. The plantlets grown in those media also showed remarkable antioxidant activities with an IC50 value of 4.77 mu g/mL in DPPH and 100% inhibition in beta-carotene assays, respectively. HPLC analysis proved the production of protocatechuic, caffeic, vanillic, rosmarinic, ferulic, and o-coumaric acids and rutin. Rosmarinic acid production was predominant in natural samples (115.2 mg/100 g dry weight), while the aforesaid phenolic acids were prevalent in plantlets grown on MS media supplemented with KIN or BA at various concentrations. Rutin production was the highest (50.74 mg/100 g dry weight) in the plantlets grown on MS medium containing kinetin (1.0 mg/L). As an economically important chemical, rosmarinic acid was selected as the target chemical and a novel method was introduced to achieve its selective isolation.
AtıfScopus6WoS5OpenAlex9TR Dizin2İncele - MakaleYalnız künye2017Scopus SJRQ2Microindentation on the porous copper surface modulations
Ekmekci, Dursun; Yilmaz, Fikret; Kölemen, Ugur; Cora, Omer Necati
This study aimed to investigate the mechanical properties of a surface modulation which was realized through compaction, and then sintering of copper powders. To this goal, Berkovich type of indenter and depth-sensing indentation technique were used in microindentation to measure the hardness and modulus of elasticity values at different features of compact. Indentations were performed with a peak force of 50 mN. Hardness values were obtained in 0.88-1.12 GPa range while the modulus of elasticity was recorded in the 70-111 GPa interval. Even though both modulus of elasticity and hardness values were noted to be different for copper powders and substrate, one-way ANOVA analyses showed that the differences in both modulus of elasticity and hardness values are insignificant. FE modeling of microindentation was also performed and validated. It was shown that the force-displacement values obtained from FE analyses are quite well in agreement with the experimental data.
AtıfScopus4WoS5OpenAlex4İncele - Kitap BölümüYalnız künye2016Marketing approach for non-profit organizations
Ayyildiz, Hasan; Akmermer, Bilgen; Akyüz, Ahmet Mutlu
All marketing definitions focus on the same point: customer orientation and the satisfaction of customer needs. Within this framework, although marketing approach in most of studies primarily deal with institutions and enterprises in profit/private sector, it has become crucial for all kind of organizations including non-profit ones. In recent years, many non-profits have grown larger and continue to improve their growth and effectiveness. In this sense, marketing is touchstone of developing non-profits. This part hopes to create a perspective to marketing definition to understand the relevance of marketing to non-profit organizations and how marketing strategies should be adapted to them for success.
AtıfScopus5OpenAlex5İncele - MakaleAçık Erişim2016Scopus SJRQ2Comparison of flow behavior and physicochemical characteristics of low-cholesterol mayonnaises produced with cholesterol-reduced egg yolk
Yüceer, M.; Ilyasoǧlu, H.; Özçelik, B.
Egg yolk is common functional ingredient in food production, mainly in mayonnaise as an emulsifier. Egg yolk cholesterol was removed using β-cyclodextrine, treated with α-Amylase, and low-cholesterol mayonnaise produced. The flow behavior of cholesterol-reduced mayonnaise was investigated at different cholesterol-reduced egg yolk and xanthan gum content. The aim of this study was to evaluate the effects of different formulations at various percentages of egg yolk (EY; 4 and 6 percent by weight) and xanthan gum (XG; 0.5 and 0.7 percent by weight) on flow behavior and physicochemical properties of reduced-fat and low-cholesterol mayonnaise prepared with cholesterol-reduced liquid egg yolk and to obtain suitable model for mayonnaise formulations. The aim of the study was to develop a reduced-fat and lowcholesterol mayonnaise with properties similar to those of typical mayonnaise in the market. For this purpose, four reduced-fat and low-cholesterol mayonnaise formulations were prepared in the laboratory using cholesterol-reduced EY. They were compared with a commercial mayonnaise from a local market as a control sample. According to results, color parameters and flow behaviors of the samples compared with the control sample indicated that the samples had higher values of lightness and yellowness, and presented lower values of yield stress and flow behavior index and higher values of consistency coefficient with respect to the commercial product, except recipe that included 6% of EY and 0.7% of XG, which exhibited similar values to the typical commercial one in the market. The Herschel Bulkley model was employed in order to evaluate the effect of EY and XG ratios on mayonnaise rheological behavior. In general, the results obtained suggest that the recipe with EY (6 wt%) and XG (0.7 wt%) had better rheological characteristics and physicochemical properties those prepared with various formulations, maintaining the reduced-fat and low-cholesterol mayonnaise prepared with β-cyclodextrine-Treated cholesterol-reduced EY. It can be interpreted that the developed product may have potential use in industrial application.
AtıfScopus17WoS17OpenAlex20İncele - MakaleYalnız künye2016Scopus SJRQ2Improving Rheological and Baking Properties of Gluten-Free Breads Using Defatted Hazelnut Flour with Various Gums
Tunç, Merve T.; Kahyaoglu, Talip
Defatted hazelnut flour (DHF) in different levels (5%, 10% and 15%) of locust bean, guar and xanthan gum were added in rice-based gluten-free formulations to improve rheological properties of dough and baking properties of bread. The rheological characteristics of dough samples were determined by steady flow curves and dynamic tests. The baking properties of breads were evaluated by specific volume, Textural Profile Analysis (TPA) parameters and color values. The rheological measurements showed that all gluten-free dough had pseudoplastic behavior. Specific volume values of breads ranged from 2.20 to 2.83cm3/g. Gum addition enhanced the specific volume of gluten-free breads. Hardness values of gluten-free breads ranged from 1,069.80 to 3,135.88 g and DHF addition of gluten-free formulations caused significant decrease of the hardness values of breads (p < 0.05). DHF addition in gluten-free formulations made bread crumb darker than bread without DHF and gum. DHF addition also increased a and b values of gluten-free bread's crumb.
AtıfScopus15WoS12OpenAlex17İncele - MakaleYalnız künye2016Scopus SJRQ2Increased expressions of ADAMTS-13 and apoptosis contribute to neuropathology during Toxoplasma gondii encephalitis in mice
Dincel, Gungor Cagdas; Atmaca, Hasan Tarik
Toxoplasma gondii (T. gondii) is a protozoan parasite with the potential of causing severe encephalitis among immunocompromised humans and animals. Our previous study showed that T. gondii induces high nitric oxide (NO) production, high glial activation (GFAP) and neurofilament expressions, leading to severe neurodegeneration in toxoplasma encephalitis (TE) in the central nervous system (CNS). The aim of this experimental study was to investigate ADAMTS-13 expression and apoptosis in CNS and to identify whether they have any correlation with toxoplasmosis neuropathology and neurodegeneration. Mice were infected with ME49 strain T. gondii and the levels of ADAMTS-13, caspase 3, caspase 8, caspase 9, TNFR1 and Bcl-xL expressions were examined in brain tissues by immunohistochemistry, during the development and establishment of chronic infections at 10, 30 and 60days post-infection. Results of the study revealed that the levels of ADAMTS-13 (P < 0.005), caspase 3 (P < 0.05), caspase 8 (P < 0.05), caspase 9 (P < 0.005) and TNFR1 (P < 0.05) expressions in the brain markedly increased while Bcl-xL expression decreased (P < 0.005). The most prominent finding from our study was that 10, 30 and 60days post-infection ADAMTS-13 increased significantly and this may play an important role in the regulation and protection of the blood-brain barrier integrity and CNS microenvironment in TE. These results also suggest that T. gondii-mediated apoptosis might play a pivotal role and a different type of role in the mechanism of neurodegeneration and neuropathology in the process of TE. Furthermore, expression of ADAMTS-13 might give an idea of the progress and is critical for diagnosis of this disease. To the best of the authors' knowledge, this is the first report on ADAMTS-13 expression in the CNS of T. gondii-infected mice.
AtıfScopus31WoS29OpenAlex32
İncele - MakaleYalnız künye2016Scopus SJRQ1Theory of Justice, OCB, and Individualism: Kyrgyz Citizens
Özbek, Mehmet Ferhat; Yoldash, Mohammad Asif; Tang, Thomas Li-Ping
Research suggests that organizational justice (procedural, distributive, and interactional justice) has important impacts on work-related attitudes and behaviors, such as organizational citizenship behavior (OCB). In this article, we explore the extent to which individualism moderates the relationship between organizational justice and OCB (organizational obedience, participation, and loyalty) among citizens in Kyrgyzstan. We make additional contributions to the literature because we know very little about these constructs in this former Soviet Union country, Kyrgyzstan, an under-researched and under-represented region of the world. Results of our data collected from 402 managers and employees in Kyrgyzstan offer the following new discoveries. All three justice constructs are related to OCB. Individualism moderates only the distributive and interactive justice to OCB relationships. We develop an intricate theory with provocative implications: Procedural justice produces obedience. For “individualists,” interactional justice inspires loyalty and, interestingly, distributive justice “can only buy” participation, but “can’t buy” loyalty. Therefore, for individualists, interactional justice outweighs distributive justice for organizational loyalty. Based on Kyrgyz citizens’ justice, OCB, and individualism, our theory reveals novel insights regarding culture, money attitude, and intrinsic motivation and provides critical and practical implications to the field of business ethics.
AtıfScopus37WoS29OpenAlex47İncele - Kitap BölümüAçık Erişim2016The effects of an accounting information system on the institutionalisation level of enterprises
Cam, Handan; Tosunoglu, Busra
An accounting information system (AIS) is a system of collecting, storing, and processing financial and accounting data that is used by decision makers. An accounting information system is generally a computer-based method for tracking accounting activity in conjunction with information technology resources. The purpose of this study is to determine the effects of an accounting information system on the institutionalisation level of enterprises. In this regard, a model has been developed and tested. Five hypotheses were constituted to test the model and a questionnaire was conducted to 150 firms that are operating in small and medium sized enterprises in Trabzon. The structural equation model was used to test the hypotheses. According to findings of the analysis it may be seen that an interdepartmental information system, compliance with an accounting information system, and an accounting information system activity have an effect on the institutionalisation level of enterprises.
AtıfScopus1OpenAlex1İncele - MakaleAçık Erişim2016Scopus SJRQ2Combustion Characteristics of Impregnated and Surface-treated Chestnut (Castanea sativa Mill.) Wood Left Outdoors for One Year
Fidan, Muhammed Said; Yaşar, Şekip Şadiye; Yaşar, Mehmet; Atar, Musa; Alkan, Elif
Treating wood with impregnating materials in order to improve resistance to burning is a commonly employed safety measure. In this study, chestnut (Castanea sativa Mill.) wood samples were impregnated using either Tanalith-E or Wolmanit-CB according to ASTM-D 1413-76 and surface-treated using water-based or synthetic varnish according to ASTM-D 3023. These samples were used to investigate the combustion characteristics of samples left outdoors for one year as detailed in ASTM-E 160-50. The combustion temperatures of the samples left outdoors were similar upon impregnation with either Tanalith-E or Wolmanit-CB. However, the combustion temperature of the samples treated with synthetic varnish was lower than those that were treated with water-based varnish. The time to collapse and the total duration of combustion of the samples left outdoors were shorter for those impregnated with Wolmanit-CB. Weight loss of the samples left outdoors was higher for those that were impregnated with Tanalith-E and treated with water-based varnish. Gas analysis of the samples that were left outdoors indicated that the O2 content of flue gas from samples that were impregnated with Wolmanit-CB and treated with synthetic varnish was high and the CO content of flue gas from the same samples was low.
AtıfScopus5WoS4OpenAlex8İncele - MakaleAçık Erişim2016Scopus SJRQ3Evaluation of the radioprotective effect of Turkish propolis on foreskin fibroblast cells
Yalcin, Can; Aliyazicioglu, Yuksel; Demir, Selim; Turan, Ibrahim; Bahat, Zumrut; Misir, Sema; Deger, Orhan
Aim of Study: Propolis is a resinous bee product, rich of polyphenolic compounds and flavonoids. It is known that in different geographic zones its chemical composition varies due to the different plant sources. Many biological properties including antimicrobial, antioxidative, anti-inflammatory, antitumoral, antigenotoxic, antimutagenic, cytostatic activities have been ascribed to propolis. These biological effects are predominantly attributed to its content of polyphenols. In this study, we aimed to evaluate the radioprotective effect of ethanolic extract of Turkish propolis. (EETP) against γ-ray-induced DNA damage on fibroblast cells using comet assay for the first time. Materials and Methods: Fibroblast cells were pretreated 15 and 30 min with concentrations of 100, 200 and 300 μg/mL EETP then they were exposed to 3 Gy γ-rays. Amifostine (synthetic aminothiol compound) was used as a positive control. Results: The results showed a significant decrease in γ-ray-induced DNA damage on cells treated with EETP and amifostine when compared to only irradiated cells. (P < 001). Conclusion: It was concluded that EETP prevent γ-ray-induced DNA damage in fibroblast cells and might have radioprotective activity.
AtıfScopus20WoS24OpenAlex25İncele - MakaleYalnız künye2016Scopus SJRQ2Simplified Early Stopping Criterion for Belief-Propagation Polar Code Decoders
Simsek, Cemaleddin; Turk, Kadir
As the first theoretically proven capacity-achieving error correction code, polar codes have become a milestone in information theory field, which draw serious attention by its low complexity encoding and decoding structures. For the decoding section, studies are focused on efficient and low complex algorithms based on successive cancellation and belief-propagation (BP) decoders. To reduce computational complexity of BP-based decoders further, early stopping methods that avoid unnecessary iterations can be used. In this letter, we propose a reduced complexity early stopping method for BP-based polar code decoders. The proposed method is based on the hypothesis that observing only a small cluster of information bits polarized to the highest error probabilities is enough to detect successful decoding. Simulation results show that the proposed early stopping criterion significantly reduces the computational complexity of successful decoding detection as well as the total operation numbers of the whole decoding process compared with previous methods in the literature.
AtıfScopus45WoS41OpenAlex47İncele - BildiriAçık Erişim2016A Study on the Performance of GPR for Detection of Different Types of Buried Objects
Toksoz, Derya; Yilmaz, Isik; Seren, Aysel; Mataraci, Isil; Salame, C.; Aillerie, M.; Papageorgas, P.
The objective of this research is to evaluate the applicability of Ground Penetrating Radar (GPR) method to detect burried objects in the shallow depths using 250 MHz and 800 MHz center frequency antennas. For this purpose, different objects were burried in several places of a certain test site. GPR data were collected along six paralel profiles using 250 MHz and 800 MHz antennas which are compatible with RAMAC CU II system. The reflections profile data were processed using the computer program ReflexW. After the processing of data, the reflected /scattered reflections on the processed radargrams were examined and the radargrams were interpreted to determine the depths and positions of the objects from the surface. Also, the data obtained from 250 and 800 MHz antennas were compared and the differences between them in terms of resolution were discussed.
AtıfScopus7WoS2OpenAlex4İncele - MakaleYalnız künye2016Scopus SJRQ1Logistics center site selection by ANP/BOCR analysis: A case study of Turkey
Peker, Iskender; Baki, Birdogan; Tanyas, Mehmet; Murat Ar, Ilker
Site selection for logistics centers is one of the most strategic decisions in logistics. This study addresses the problem of logistics center site selection, using Analytic Network Process/Benefits, Opportunities, Costs and Risks, which is a multi-criteria decision making technique. The decision problem is applied to the city of Trabzon, which is an important city of the Eastern Black Sea Region in Turkey. First, the results are evaluated in terms of each sub-network and each group and, next, are consolidated for each alternative. They yield that Alternative A is the most appropriate logistics center location of all in Trabzon. Furthermore, the sensitivity analysis results emphasize that the decision model is robust.
AtıfScopus40WoS34OpenAlex45İncele - BildiriAçık Erişim2016The comparison of performance by using alternative refrigerant R152a in automobile climate system with different artificial neural network models
Kalkisim, A.T.; Hasiloglu, A.S.; Bilen, K.; Durak, R.; Tuzemen, S.
Due to the refrigerant gas R134a which is used in automobile air conditioning systems and has greater global warming impact will be phased out gradually, an alternative gas is being desired to be used without much change on existing air conditioning systems. It is aimed to obtain the easier solution for intermediate values on the performance by creating a Neural Network Model in case of using a fluid (R152a) in automobile air conditioning systems that has the thermodynamic properties close to each other and near-zero global warming impact. In this instance, a network structure giving the most accurate result has been established by identifying which model provides the best education with which network structure and makes the most accurate predictions in the light of the data obtained after five different ANN models was trained with three different network structures. During training of Artificial Neural Network, Quick Propagation, Quasi-Newton, Levenberg-Marquardt and Conjugate Gradient Descent Batch Back Propagation methodsincluding five inputs and one output were trained with various network structures. Over 1500 iterations have been evaluated and the most appropriate model was identified by determining minimum error rates. The accuracy of the determined ANN model was revealed by comparing with estimates made by the Multi-Regression method.
AtıfScopus1OpenAlex2İncele - BildiriYalnız künye2016Determination of the dynamic characteristics of the faculty building of law at KTU campus with HVSR and FSR methods
Bekar, Y.; Coban, K.H.; Sayil, N.
Seismic response characteristics of structures can be estimated by spectral ratios of microtremors measured on structures and their foundation ground surface. The microtremor horizontal-To-verticalspectral- ratio (HVSR) technique has received great attention from all over the world with its simplicity together with quick information about dynamic characteristics of ground and structures. The HVSR of microtremors gives a good estimation of natural building frequency. In this study, Horizontal-To-Vertical- Spectral-Ratio HSVR method and Floor Spectral Ratio Method (FSR) has been applied to microtremor records taken with three component broad band velocity seismometers in three different locations inside the building and one at outside with the aim of determining the dynamic characteristics of Faculty building of Law at The Karadeniz Technical University (KTU), in Turkey. The average predominant frequency, period and amplification values for the Faculty building of Law are calculated. The vibration frequency and period is around 3.5 Hz and 0.283 s, respectively. The amplitude values increase to the upper floors.
- MakaleAçık Erişim2016Scopus SJRQ2Kinetic and in silico studies of hydroxy-based inhibitors of carbonic anhydrase isoforms I and II
Ekhteiari Salmas, Ramin; Mestanoglu, Mert; Durdagi, Serdar; Sentürk, Murat; Kaya, A. Afşin; Kaya, Elif Çelenk
A series of hydroxy and phenolic compounds have been assayed for the inhibition of two physiologically relevant carbonic anhydrase (CA, EC 4.2.1.1) isozymes, the cytosolic human isozymes I and II. The investigated molecules showed inhibition constants in the range of 1.07-4003 and 0.09-31.5 μM at the hCA I and hCA II enzymes, respectively. In order to investigate the binding mechanisms of these inhibitors, in silico studies were also applied. Molecular docking scores of the studied compounds are compared using three different scoring algorithms, namely Glide/SP, Glide/XP and Glide/IFD. In addition, different ADME (absorption, distribution, metabolism and excretion) analysis was performed. All the examined compounds were found within the acceptable range of pharmacokinetic profiles.
AtıfScopus10WoS11OpenAlex15İncele - MakaleYalnız künye2016Scopus SJRQ1Subduction-related Late Carboniferous to Early Permian Magmatism in the Eastern Pontides, the Camlik and Casurluk plutons: Insights from geochemistry, whole-rock Sr–Nd and in situ zircon Lu–Hf isotopes, and U–Pb geochronology
Karsli, Orhan; Dokuz, Abdurrahman; Kandemir, Raif
Late Carboniferous to early Permian granitoid rocks represent a volumetrically minor component of the Eastern Pontide lithosphere, but they preserve useful information about the region's tectonomagmatic history. The Casurluk and Camlik plutons primarily consist of gabbro, gabbroic diorite, diorite, monzogabbro, monzodiorite and monzonite, which intrude early to middle Carboniferous granitic basement rocks in the region. In this study, we use in situ zircon U–Pb ages and Lu–Hf isotopic values, whole-rock Sr–Nd isotopic values, and mineral chemistry and geochemistry of these plutons to determine petrogenesis and crustal evolution; we also discuss geodynamic implications. LA–ICP-MS zircon U–Pb dating of magmatic zircons from the rocks suggests that the plutons were emplaced during the late Carboniferous to early Permian (302 Ma). The metaluminous and I-type intrusive rocks belong to the high-K calc-alkaline series. In addition, they are relatively enriched in light rare earth elements (LREEs) and large-ion lithophile elements (LILEs); they are depleted in heavy rare earth elements (HREEs) and high field strength elements (HFSEs), such as Nb and Ti. All of the samples have homogeneous initial ISr values (0.70675 to 0.70792) and low εNd (t) values (− 5.1 to − 3.3). Zircons from the rocks of both plutons have uniform negative to slightly positive εHf (t) values (− 3.5 to 1.4) and old Hf two-stage model ages (1323 to 1548 Ma), implying that they have the same source, as well as suggesting the involvement of old enriched lithospheric mantle materials during their magma genesis. These results, combined with the εHf (t) values and two-stage model ages, demonstrate that the primary magmas were derived from partial melting of old lithospheric mantle material metasomatized by subduction-related fluids. Considering other regional geological data from the Sakarya Zone where these plutons formed, we conclude that late Carboniferous to early Permian magmatism in the area involved the partial melting of a phlogopite- and spinel-bearing lherzolite under an extensional regime in a subduction-related setting. Such an extension event would have caused hot asthenospheric upwelling and was likely triggered by back-arc rifting during subduction of the Paleo-Tethyan oceanic slab. Thus, the magmas are likely subduction-related products, implying that southward subduction of Paleo-Tethys oceanic lithosphere in the region began during the late Carboniferous to early Permian.
AtıfScopus59WoS55OpenAlex65İncele