Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(77)
- Merdan, Mehmet(73)
- Duran, Celal(54)
- Ozdes, Duygu(50)
- Baltaci, Cemalettin(45)
- Kaygusuz, Abdullah(45)
- Kulakaç, Nurşen(39)
- Ashyralyyev, Charyyar(38)
- Karsli, Orhan(37)
- Demir, Selim(36)
- Öztürk, Serkan(36)
- Dokuz, Abdurrahman(35)
- Turan, Ibrahim(35)
- Araz, Onur(33)
- Kandemir, Raif(31)
- Sipahi, Ferkan(30)
- Topal, Fevzi(30)
- Kurt, Kemal(28)
- Peker, Iskender(28)
- Arslan, Mehmet(27)
- Baltacı, Cemalettin(27)
- Maden, Nafiz(27)
- Ozturk, Samet(27)
- Aydin, Aydanur(26)
- Vural, Alaaddin(26)
- Bayrakdaroglu, Serdar(25)
- Kurnaz, Muammer(25)
- Reis, Hatice Catal(25)
- Akar, Zeynep(24)
- Aydin, Faruk(24)
- Gücer, Mehmet Ali(24)
- Topal, Meryem(24)
- Yolcu, Halil(24)
- Yücel, Cem(24)
- Anaç, Halil(23)
- Kankal, Murat(23)
- Ürkek, Bayram(23)
- Aliyazicioglu, Yuksel(22)
- Günen, Mehmet Akif(22)
- Tuncer, Metin(22)
Yayınlar
- MakaleAçık Erişim2025Scopus SJRQ1The effects of sub-components of economic freedom on load capacity factor: Empirical analysis for MENA countries
Senturk, Nazli Keyifli; Bayraktar, Yuksel; Recepoglu, Mursit; Ozyilmaz, Ayfer; Balsalobre-Lorente, Daniel
This study investigates the effects of economic freedom sub-components on load capacity factor (LCF) in 12 MENA countries for 2017-2022. The 12 sub-components of the economic freedom index were used as independent variables, and the load capacity factor was used as the dependent variable. In the study, four-panel data models were created using the subcomponents of the economic freedom index, and a two-stage System-GMM was used. According to the study, while property rights reduce the load capacity factor, Judicial Effectiveness increases it. The effect of Government Integrity on the load capacity factor is statistically insignificant. While Government spending negatively affects the load capacity factor, Tax Burden and Fiscal Health are statistically insignificant. Business freedom affects the load capacity factor positively, but monetary freedom affects it negatively. Labour freedom is statistically insignificant. On the other hand, trade freedom and investment freedom have a positive impact on the load capacity factor, while financial freedom has a negative effect.
AtıfScopus8WoS7OpenAlex8
İncele - MakaleAçık Erişim2025Scopus SJRQ1Sulfonamide-Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME/T Profiling and Molecular Docking Study
Lolak, Nebih; Akocak, Suleyman; Topal, Meryem; Koçyigit, Umit Muhammet; Isik, Mesut; Türkes, Cuneyt; Topal, Fevzi; Durgun, Mustafa; Beydemir, Sukru
The research and design of new inhibitors for the treatment of diseases such as Alzheimer's disease and glaucoma through inhibition of cholinesterases (ChEs; acetylcholinesterase, AChE and butyrylcholinesterase, BChE) and carbonic anhydrase enzymes are among the important targets. Here, a series of novel sulfonamide-bearing pyrazolone derivatives (1a-f and 2a-f) were successfully synthesized and characterized by using spectroscopic and analytical methods. The inhibitory activities of these newly synthesized compounds were evaluated both in vitro and in silico for their effect on carbonic anhydrases (hCA I and hCA II isoenzymes) and ChEs. The in vitro studies showed that these novel compounds demonstrated potential inhibitory activity, with K-I values covering the following ranges: 18.03 +/- 2.86-75.54 +/- 4.91 nM for hCA I, 24.84 +/- 1.57-85.42 +/- 6.60 nM for hCA II, 7.45 +/- 0.98-16.04 +/- 1.60 nM for AChE, and 34.78 +/- 5.88-135.70 +/- 17.39 nM for BChE. Additionally, many of these compounds showed promising inhibitory activity, and some showed higher potency than reference compounds. While the in silico studies have also identified the potential binding positions of these compounds, using the crystal structures of hCA I, II, AChE and BChE receptors. The varying affinities demonstrated by these designed compounds for ChEs and hCA isoenzymes show that these compounds could hold promise as potential alternative agents for selectively inhibiting ChEs and hCAs in the treatment of diseases such as Alzheimer's disease and glaucoma.
AtıfScopus21WoS22OpenAlex21İncele - MakaleAçık Erişim2025Scopus SJRQ1Multiple Mantle Melting and Metasomatism during the Initial Stages of Subduction: Multi-Geochemical and Os-Isotope Evidence from Well-Preserved Kızıldağ Ophiolite, southern Türkiye
Uysal, Ibrahim; Sen, Ahmet D.; Su, Ben-Xun; Ersoy, Yalcin; Demir, Yilmaz; Pan, Qi-Qi; Hu, Wen-Jun; Bagci, Utku; Godard, Marguerite
The processes governing ophiolite formation and evolution remain incompletely understood. The K & imath;z & imath;lda & gbreve; ophiolite, a well-preserved remnant of the Neo-Tethyan oceanic lithosphere in the Anatolian region, southern T & uuml;rkiye, offers critical insights into subduction-related processes and geodynamics. This study presents new element data for mineral and whole-rock samples, combined with Re-Os isotopic compositions of mantle peridotites and associated crustal rocks and extrusives. Petrographic observations identify two distinct groups of peridotites: (1) those with very low modal clinopyroxene, interpreted as highly depleted harzburgites and preserving primary mineral assemblages, and (2) depleted harzburgites containing secondary clinopyroxene with elevated trace element contents, inferred to have crystallized from percolating melts and thus reflecting metasomatic modification. Spinel and orthopyroxene compositions indicate 17-25% degrees of partial melting, with evidence for melting in both garnet and spinel stability fields. However, mineral and whole-rock compositions also record subsequent cryptic and modal metasomatism. Crustal rocks and extrusives exhibit geochemical signatures transitional between fore-arc basalts and boninites, consistent with subduction initiation settings. Variations in Os isotope ratios (187Os/188Os) in crustal rocks further reveal melt-rock interactions and the incorporation of radiogenic Os from subducted oceanic crust. The integration of petrographic, geochemical, and isotopic data supports a four-stage tectonic model for subduction initiation and mantle wedge evolution, consistent with global models proposed for supra-subduction zone (SSZ) ophiolites, particularly those of the Tethyan domain. These findings provide new constraints on mantle melting, metasomatism, and subduction initiation processes and contribute to a broader understanding of SSZ mantle evolution in both regional and global contexts.
AtıfScopus6WoS6İncele - MakaleAçık Erişim2025Scopus SJRQ2Maximizing performance in child footballers: chronotype and time of day study
Kaba, Ilknur; Engin Celikel, Baha; Adanur, Oguzhan; Yilmaz, Coskun; Yonca Sezer, Sureyya; Tan, Cetin; Durhan, Tebessum Ayyildiz; Özer, Ugur; Ceylan, Tulay
Background A limited number of studies have investigated the effects of circadian rhythm-based running exercise interventions on physical fitness in child athletes. This study aimed to investigate the effects of an eight-week morning and evening running program on lower extremity strength, agility and respiratory function in 10-12-year-old male footballers.Methods Participants visited the laboratory three times, with one-day intervals before and after the training program. The assessments included maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio. Additionally, agility and functional performance tests (FPTs) were conducted for both the dominant and non-dominant legs.Results The findings indicated that morning running was more effective than evening running in enhancing respiratory function. Morning running also showed superior results in lower extremity strength tests, particularly in the single-leg (SL) and triple-leg (THD) crossover hop for distance tests (CHDs) and the 6-m timed-hop test (6 m THT). Furthermore, the agility performance of the morning running group was significantly better than that of the evening and control groups.Conclusion Consequently, morning running interventions had a positive impact on key physical fitness parameters, including respiratory muscle strength, respiratory function, agility, and lower extremity strength in child footballers.
- MakaleYalnız künye2025Scopus SJRQ1Dense Seismic Recordings of the 2023 KahramanmaraşEarthquake Sequence in Southeastern Türkiye
Zor, Ekrem; Peng, Zhigang; Ergin, Mehmet; Sandvol, Eric; Sevim, Fatih; Rdamaz, Mustafa Cengiz Tap i; Mach, Phuc; Yalvac, Ouzhan; Tarancioglu, Adil; Adeboboye, Oluwaseyifunmi
The devastating 6 February 2023 Kahramanmara & scedil;earthquake sequence in southeastern T & uuml;rkiye started with a moment magnitude (Mw) 7.8 earthquake, for which the initial rupture broke the Sak4ag & ouml;z segment near Nurda & gbreve;& imath; and then jumped into a bilateral rupture along multiple segments of the Eastern Anatolian fault zone (EAFZ). This complicated rupture was followed nine hours later by an Mw 7.6 event near Ekin & ouml;z & uuml;. To better understand the spatiotemporal evolution of aftershocks, site amplification, and the structural and tectonic framework of the EAFZ in this diffuse triple junction, we deployed a dense seismometer array covering both aftershock zones for nearly four months. The main Eastern Anatolian Seismic Temporary (EAST) array includes 125 nodal, 10 broadband, and 6 strong-motion seismic stations distributed around the rupture zone. An additional linear array of 73 nodal stations was also installed across the Pazarc & imath;k segment of the EAFZ and the Sak4ag & ouml;z segment near the Mw 7.8 epicenter to record fault-zone waves for similar to 30 days. This article shows example recordings and the EAST array geometry, preliminary research results, and the metadata related to all of the stations in this array. A deep-learning-based phase picking for one month of continuous recording yielded millions of seismic phase readings and tens of thousands of aftershock locations after phase associations. We also give examples of both local and teleseismic waveforms recorded by the nodal arrays, which can be used for subsequent high-resolution earthquake relocation, imaging of crustal structures, and fault-zone imaging.
AtıfScopus5WoS5OpenAlex7İncele - MakaleYayıncıda açık erişim2025Scopus SJRQ2Could Different Doses of Dexmedetomidine Be as Effective as Amifostine Against Radiotherapy-Induced Liver Injury in Rats? Evidence from Mitotic, Apoptotic, Oxidative, and Neurogenic Insights
Beyazal Polat, Hatice; Yilmaz, Hamit; Demir, Kasim; Kilinc, Kagan; Gülhan, Belemir; Rakici, Sema Yilmaz; Tumkaya, Levent
Background/Objectives: Radiotherapy (RT) induces oxidative stress and structural damage in solid tissues, including the liver. This study aimed to investigate the histological and immunohistochemical effects of dexmedetomidine (DEX) and amifostine on their potential protective and regenerative properties against liver injury induced by radiation therapy. Methods: This study consisted of five randomized groups: control, RT, RT-D100, RT-D200, and RT-A (Amifostine). A total of 100 mu g/kg DEX, 200 mu g/kg DEX, and 200 mu g/kg amifostine were administered before radiotherapy as per the experimental design. After RT, liver specimens were analyzed for histological alterations, including periportal and perisinusoidal fibrosis, vacuolization, and pyknotic nuclei. Furthermore, immunohistochemistry investigations were conducted to evaluate apoptosis, mitosis, oxidative stress, and neural regeneration in non-neuronal liver tissue following radiotherapy and subsequent treatment. Results: The control group's liver tissue exhibited standard histological architecture, whereas the RT group displayed severe cellular degeneration, periportal and perisinusoidal fibrosis, cytoplasmic vacuolization, and an increase in pyknotic nuclei. The apoptotic index was markedly reduced in the RT-D100 and RT-D200 groups relative to the RT group. Furthermore, caspase-3 immunoactivity was negligible in the control group, while a significant increase was observed in the RT group. The administration of amifostine significantly increased GAP-43 levels. Conclusions: DEX mitigates RT-induced hepatic injury chiefly through antioxidant and anti-apoptotic pathways, whereas amifostine promotes hepatic regeneration by modulating GAP-43.
- MakaleAçık Erişim2025Scopus SJRQ2Effect of Inspiratory Muscle Training on Diaphragm and Abdominal Wall Muscle Thickness with Fatty Liver Density in Elderly Women: A Randomized Controlled Trial
Gökçelik, Eda; Yilmaz, Coskun; Budak, Cemallettin; Soylu, Hakan Huseyin; Bayrakdaroglu, Serdar; Ceylan, Halil Ibrahim; Muntean, Raul Ioan; Küçük, Hamza; Ceylan, Levent
Background and Objectives: Post-menopausal estrogen decline is considered a contributing factor to sarcopenia, and inspiratory muscle training (IMT) may provide benefits in this demographic. This study examined the impact of a four-week IMT program on diaphragm thickness, abdominal wall muscle thickness (AWMT; transversus abdominis, internal oblique, and external oblique), and liver fat percentage in healthy elderly women. Materials and Methods: Twenty-six women aged 60-80 years were randomly assigned to an IMT group (n = 13) or a control group (n = 13). The IMT group used the PowerBreathe (R) Classic device at 40% of maximal inspiratory pressure (MIP), with weekly increments of 10%. Training was performed twice daily, five days per week, with 30 breathing cycles per session (60 per day). The control group maintained their usual routines. AWMT, diaphragm thickness (DT), and fatty liver density (FLD) were measured by a radiologist before and after the intervention. Results: After four weeks, the IMT group showed significant improvements in all parameters compared to controls. Mid-diaphragm thickness (MDT) increased by 11.44% (effect size (ES) = 0.358, p < 0.001) versus 0.76% in controls (p = 0.271). Posterior diaphragm thickness (PDT) improved by 7.48% (ES = 0.282, p < 0.001) versus 0.38% (p = 0.564). Right AWMT increased by 12.7% (ES = 0.492, p < 0.001) compared to 0.10% (p = 0.872), and left AWMT increased by 9.93% (ES = 0.395, p < 0.001) versus 2.64% (p = 0.014). FLD improved by 11.79% (ES = 0.959, p < 0.001) in the IMT group, while the control group showed no meaningful change (-0.13%, p = 0.847). Conclusions: A short-term IMT protocol significantly enhanced diaphragm and AWMT and reduced liver fat in elderly women. These findings support the use of IMT as a simple, non-invasive intervention to preserve musculoskeletal and metabolic health in aging populations.
AtıfScopus4WoS4OpenAlex6İncele - MakaleAçık Erişim2025Scopus SJRQ1Taekwondo exercises for women improve quality of life, physical self-defence skills, and psychological resilience
Yikilmaz, Ahmet; Yilmaz, Coskun; Çiçekli, Atif; Eryilmaz, Onder; Budak, Cemalettin; Uyar, Musa; Ceylan, Tulay; Güler, Ozkan; Sahin, Fatma Nese
Background: The extant research on Taekwondo has focused primarily on the physiological effects of training, with limited interest in psychological resilience, self-defence and quality of life levels. The present study examined the effects of Taekwondo exercises on psychological resilience, self-defence and quality of life levels in healthy female subjects. Methods: The present study comprised 30 healthy, sedentary female subjects. The subjects were randomly divided into two groups: one group participated in Taekwondo training (TG), while the other group served as the control group (CG). The sample sizes for both the TG and CG groups were 15. The TT group underwent conventional Taekwondo instruction, while the CG group maintained their habitual routine and refrained from sporting pursuits. The Brief Psychological Resilience Scale, the Physical Self-Defence Scale for Women, and the SF-12 Quality of Life Scale were administered before and after the six-week training period. Results: The 6-week Taekwondo training programme led to significant improvements in both physical health (PH) (p = 0.049) and mental health (MH) (p < 0.01) scores in female participants. It did not produce a significant change in psychological resilience (PR) scores (p > 0.05). It produced significant improvements in self-defence against simple physical attacks (SP) (p = 0.004) and self-defence against dangerous physical attacks (DP) (p = 0.041) scores. Conclusion: The positive effects of Taekwondo training on psychological resilience, physical self-defence and quality of life levels have been demonstrated in healthy female subjects. This study provides valuable insights into the impact of Taekwondo exercises on psychological resilience, physical self-defence and quality of life levels. The findings of this study can guide future intervention and programme design in the context of sports psychology.
AtıfScopus2WoS4OpenAlex4İncele - MakaleAçık Erişim2025Scopus SJRQ1Short-term resistance training enhances functional and physiological markers in older women: implications for biomechanical and health interventions in aging
Uçar, Mine Akkus; Yilmaz, Coskun; Soylu, Hakan Huseyin; Sariakçali, Baris; Budak, Cemalettin; Kavuran, Korhan; Durmusoglu, Mehmet Vakif; Ceylan, Levent
Background: The impact of resistance training extends beyond the enhancement of muscle strength, encompassing improvements in physical performance, postural stability, and overall functional capacity. This study aimed to investigate the effects of a 4-week resistance training program on functional capacity, respiratory muscle strength, diaphragm thickness, and liver density in healthy older women. Methods: The study included 30 healthy women aged 60-80 years and was designed as a randomized controlled experimental trial. Participants were randomly assigned to a resistance training (RT) group or a control (CON) group. Each participant attended the laboratory on three occasions: during the initial visit, the study procedures were explained; the second visit involved baseline assessments (6MWT, diaphragm thickness and liver fat via ultrasound, and respiratory muscle strength); and final measurements were conducted after the 4-week training programme during the third visit. Results: When pre- and post-training measurements were compared, the resistance training (RT) group demonstrated a significantly greater improvement (8.02%) in the Six-Minute Walk Test (6MWT) distance compared to the control group (p < 0.001). In terms of diaphragm thickness (DT), the RT group showed a 16.66% increase, whereas the control group exhibited a 1.13% decrease (p < 0.001). Maximal inspiratory pressure (MIP) increased by 12.30% in the RT group, while it decreased by 7.25% in the control group, indicating a 19.55% greater improvement in the RT group (p < 0.001). Regarding maximal expiratory pressure (MEP), a significant improvement of 21.48% was observed in the RT group, whereas a 0.75% decrease was recorded in the control group, resulting in a 22.23% greater enhancement in the RT group (p < 0.001). Finally, liver density (LD) increased by 12.30% in the RT group, while it decreased by 7.25% in the control group (p < 0.001). Conclusion: As a result of resistance training, greater improvement was observed in functional capacity, respiratory muscle strength, diaphragm thickness and liver density in the training group compared to the control group.
AtıfScopus2WoS1İncele - MakaleAçık Erişim2025Scopus SJRQ2Determination of Mineral, Fatty Acid, and Soluble Carbohydrate Profiles of Green Algae Ulva rigida, Chaetomorpha linum, Codium fragile, Caulerpa prolifera and Caulerpa racemosa f. requienii Collected from Turkiye Coasts
Yucetepe, Aysun; Altuntas, Umit; Sensu, Eda; Izci, Yunus; Ozcelik, Beraat; Okudan, Emine Sukran
The nutritional properties of five different green macroalgae including Ulva rigida, Chaetomorpha linum, Codium fragile, Caulerpa prolifera and Caulerpa racemosa f. requienii from Turkey were investigated. The chemical composition of green macroalgae was varied, with ash, crude fiber, protein, lipid and carbohydrate ranging from 40.71 to 52.82%, 12.02-17.56%, 4.40-26.19%, 0.57-3.85% and 4.58-42.28% in dry weight, respectively. The fatty acid contents of the algae were quite variable and palmitic acid (C16) was found to be the primary fatty acid for all the samples with a value of more than 49.61%. Palmitic acid was followed by oleic acid, which is a monounsaturated fatty acid. This study revealed that green algae are rich in important soluble carbohydrates such as myo-inositol and glucose, health promoting unsaturated fatty acids (mainly oleic acid) and essential macroelements such as potassium, magnesium and microelements such as iron, zinc and selenium. The results of the current study contribute to a better understanding of macroalgae and encourage their use in food-related applications.
AtıfScopus4WoS3OpenAlex2İncele - MakaleYayıncıda açık erişim2025Scopus SJRQ2Serum neopterin and kynurenine as predictive and prognostic biomarkers in prostate cancer: the role of dietary inflammatory index and biomarker interactions
Icer, Mehmet Arif; Koçak, Tevfik; Acar-Tek, Nilufer; Yesil, Suleyman; Icer, Yusuf
Background It has been shown that neopterin levels in various body fluids can help predict the diagnosis of different malignancies. Although many studies have investigated the roles of serum neopterin concentrations, tryptophan metabolism, and the dietary inflammation index (DII) in various cancers, the connection between these factors and prostate cancer (PC) remains uncertain. The aim of this study was to investigate the predictive and prognostic roles of serum neopterin, and kynurenine levels, along with the kynurenine-to-tryptophan ratio (KTR) and DII in prostate cancer. Methods This study was conducted with 57 newly diagnosed prostate cancer patients, 55 benign prostate hyperplasia patients, and 56 healthy male individuals in the control group, all aged 40 years and older. Participants had specific anthropometric measurements taken, and three-day food records were kept. DII was calculated based on data for thirty-four available nutrients by using food records. Serum levels of neopterin, kynurenine, tryptophan, tumor necrosis factor alpha (TNF-alpha), and interferon-gamma (IFN-gamma) were measured using an enzyme-linked immunosorbent assay (ELISA) method. Results Serum neopterin (11.79 +/- 6.09), kynurenine (1655.48 +/- 1122.04), TNF-alpha (221.59 +/- 232.06) and IFN-gamma (137.68 +/- 107.11) levels were higher in the malignant group than in both the control (2.72 +/- 0.76, 352.40 +/- 69.33, 223.94 +/- 226.67, and 23.03 +/- 7.28, respectively) and benign groups (3.17 +/- 0.74, 377.94 +/- 109.05, 179.61 +/- 224.36, and 25.63 +/- 7.50, respectively) (p < 0.05). Another result of our study is that in the malignant group, serum neopterin levels exhibited significant positive correlations with serum kynurenine (r = 0.80, p < 0.0001), IFN-gamma (r = 0.86, p < 0.0001) and TNF-alpha levels (r = -0.27, p = 0.0453) and DII (r = 0.30, p = 0.0229), while they exhibited weak correlations with serum PSA, and other diet parameters. Additionally, kynurenine was the only parameter showing significant differences in mean values concerning surgical margins (p < 0.05). Conclusions The findings of this study support the hypothesis that serum neopterin and specific tryptophan catabolites (e.g., kynurenine), could serve as predictive and prognostic biomarkers for prostate cancer diagnosis. However, our results do not support the hypothesis that DII and certain dietary factors play a direct role in the development or diagnosis of prostate cancer.
AtıfScopus3WoS3OpenAlex2İncele - MakaleAçık Erişim2025Scopus SJRQ1A comprehensive and realistic performance evaluation of post-quantum security for consumer IoT devices
Hanna, Yacoub; Bozhko, Jessica; Tonyali, Samet; Harrilal-Parchment, Ricardo; Cebe, Mumin; Akkaya, Kemal
The computational capacity envisaged for quantum computers poses a significant threat to today's traditional cryptographic algorithms. Although they are not yet large enough to compromise current cryptographic protocols, one can practice retrospective decryption since data packets traveling through the Internet can be easily sniffed. This threat extends to wireless communication security within consumer IoT devices that use lightweight cryptography due to limited computational power. Thus, countermeasures against potential quantum attacks should be preemptively adopted. NIST is leading efforts to standardize several algorithms as quantum-resistant Key Exchange Mechanisms (KEMs) and Digital Signatures. In this paper, we investigate the viability of these Post-Quantum algorithms in the Transport Layer Security (TLS) of power-constrained IoT devices. Specifically, it focuses on two widely used IoT network protocol stacks, i.e., Bluetooth Low Energy (BLE) and Wi-Fi. To this end, we build a realistic IoT testbed running IP over BLE. Our evaluation considers the impact of several realistic factors for the first time, such as using a chain of certificates on the server side and incorporating certificate validation methods such as Online Certificate Status Protocol (OCSP) and Certificate Revocation Lists (CRL). We also evaluate the impact of mutual authentication between the server and the client. Utilizing the outcomes of this evaluation, we then propose a novel approach for IoT devices to dynamically choose the most efficient KEM algorithm for TLS based on the device's physical network interface. The performance results provide valuable insights with respect to the TLS latency and energy consumption of consumer IoT devices.
AtıfScopus34WoS24OpenAlex34İncele - MakaleAçık Erişim2025Scopus SJRQ1Muay Thai exercises improve quality of life, love of life and self-control
Sahin, Oktay; Yilmaz, Coskun; Sezer, Sureyya Yonca; Sahin, Fatma Nese; Ceylan, Levent; Çelikel, Baha Engin; Tan, Cetin; Uçar, Mine Akkus; Kirikoglu, Nagihan
Background The existing research on Muay Thai sports has focused predominantly on the physiological effects of training, with limited attention devoted to the study of quality of life, love of life and self-control. The present study examined the effects of Muay Thai exercises on quality of life, love of life and self-control scores in healthy male subjects. Methods The present study comprised 50 healthy sedentary male subjects. The subjects were randomly divided into two groups: one group engaged in Muay Thai training (MTT), while the other group served as a control group (CON). The sample sizes for the MTT and CON groups were both 25. The MTT group participated in basic Muay Thai training, while the CON group continued their normal life regime. The SF-12 quality of life scale, love of life scale and multidimensional self-control scale were administered before and after the six-week training period. Results The study concluded that the six-week Muay Thai training program had a significant effect on quality of life levels, with 13.23% (p = 0.003) and 21.93% (p < 0.001) of participants demonstrating improvements in physical and mental scores, respectively. In terms of self-control levels, the program was found to have a significant effect on initiation and inhibition scores, with increases of 23.78% (p = 0.001) and 24.69% (p < 0.001), respectively. It was concluded that had a significant effect on the sub-dimensions of the Love of Life scale with increases of Positive Attitude Toward Life (PAWL) 18.63% (p < 0.001), Happy Results of the Love of Life (HRLL) 20.11% (p < 0.001) and Meaningfulness of Life (ML) 15.62% (p < 0.001), respectively. However, no significant differences were detected in any of the scales within the control group. Conclusion Muay Thai exercises had a positive effect on quality of life, love of life and self-control levels in healthy male subjects. By providing valuable insights into how Muay Thai exercise affects quality of life, love of life, and self-control, this research can guide future intervention and program design in the context of sport psychology.
AtıfScopus7WoS9OpenAlex8İncele - MakaleAçık Erişim2025Log-transformed approaches to variance estimation using auxiliary data
Singh, Poonam; Sharma, Prayas; Singh, Anjali; Zaman, Tolga; Emam, Walid
Reliable statistical inference requires accurate population variance estimate, especially in domains where measurement limitations and intrinsic variability impact data. Applying traditional estimators to skewed or heavy-tailed populations frequently results in inefficient results. We provide a novel class of generalized logarithmic variance estimators that use logarithmic transformations and auxiliary data to stabilize variance and improve estimator performance in order to overcome this constraint. We calculate the suggested estimators' bias and Mean Squared Error (MSE) expressions and assess their effectiveness using comprehensive Monte Carlo simulations with different sample sizes. The suggested estimator, Tr1-, produces a significant reduction in MSE up to 57% increase in efficiency (PRE) at n=600 when compared to the usual estimator. The suggested methodologies resilience and suitability for high-variability situations are further confirmed using real-world datasets. In every context, the findings show that the suggested estimators perform better than the current ones in terms of lower MSE and greater PRE. This research demonstrates how logarithmic transformations may be used to create variance estimators that are more accurate and effective, especially when auxiliary variables are provided.
AtıfWoS3İncele - Derleme MakaleAçık Erişim2025Scopus SJRQ1Synergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review
Cherappurath, Nafih; Navaf, Muhammed; Ceylan, Halil Ibrahim; Elayaraja, Masilamani; Sunooj, Kappat Valiyapeediyekkal; Satheesan, Saranya T.; Thoompenthodi, Muhammed Ali; Perumbalath, Shamshadali; Bayrakdaroglu, Serdar; Muntean, Raul Ioan
Background/Objectives: Lifestyle-related diseases such as obesity, diabetes, hypertension, metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis disproportionately affect women due to hormonal, metabolic, and socio-cultural factors. Emerging evidence suggests that combining structured exercise with nano-curcumin, a bioavailable phytochemical formulation with potent antioxidant and anti-inflammatory properties, may provide synergistic benefits. This scoping review systematically synthesizes available evidence on the combined effects of nano-curcumin supplementation and exercise interventions on health outcomes in women with lifestyle-related diseases. Methods: Following the Joanna Briggs Institute methodology and the PRISMA-ScR framework, a comprehensive database search was conducted in March 2025 and updated in June 2025. Records were retrieved from Scopus (n = 30), Web of Science (n = 22), PubMed (n = 18), and other sources (n = 71), yielding a total of 141 studies. After screening and deduplication, eight studies met the inclusion criteria and were included in this review. All the studies were conducted in Iran with small sample sizes (12-53 participants) and short intervention durations (6-16 weeks). Therefore, the current evidence is geographically and demographically limited. Results: Across the included trials, the combined interventions produced additive or synergistic improvements in oxidative stress markers, inflammatory cytokines, lipid and glucose metabolism, cardiovascular function, pulmonary capacity, muscle fitness, and psychological outcomes (e.g., depression). When paired with nano-curcumin supplementation at different concentrations, high-intensity interval training, aerobic exercise, Pilates, and resistance training consistently outperformed exercise or supplementation alone in modulating antioxidant defenses, reducing systemic inflammation, and improving metabolic risk factors. Conclusions: The integration of exercise and nano-curcumin supplementation appears to confer superior benefits for women with lifestyle-related diseases compared with either approach alone. These findings highlight the potential of combining phytochemicals with lifestyle interventions to optimize women's health outcomes. However, most available evidence originates from small, short-term studies in single geographic regions. Large-scale, multicenter, randomized controlled trials with diverse populations are warranted to establish standardized protocols and optimal dosing strategies, and to assess long-term safety and efficacy.
AtıfScopus2WoS2OpenAlex1İncele - MakaleYalnız künye2025Scopus SJRQ1Subduction initiation of the Neotethyan Ocean recorded in chromite deposits: A case study of the Kızıldag ophiolite, southern Turkiye
Uysal, Ibrahim; Akmaz, Recep Melih; Su, Ben-Xun; Demir, Yilmaz; Sen, Ahmet Dundar
The chromitites of the K & imath;z & imath;lda & gbreve; ophiolite (KO) are primarily characterized by massive and disseminated textures within refractory mantle peridotites, predominantly harzburgite and dunite, with occasional occurrences of banded and nodular chromitites. Based on chromite composition, these chromitites can be classified into two groups exhibiting a broad compositional range: intermediate (0.55 <= Cr# < 0.70, TiO2 = 0.08-0.51 wt%) and high-Cr (0.70 <= Cr# <= 0.77, TiO2 = 0.05-0.28 wt%). The compositions of minor and trace elements align consistently with variations in Cr#. Total PGE (Os, Ir, Ru, Rh, Pt, Pd) contents in these chromitites are generally less than 500 ppb, with many samples showing enrichment of IPGE (Os, Ir, Ru) relative to PPGE (Rh, Pt, Pd). However, certain samples from both groups display elevated PGE concentrations (Sigma PGE(intermediate) = 718 ppb, Sigma PGE(High-Cr) = 866 ppb) compared to other samples. The dominant platinum group mineral inclusions in chromite are Ru-rich laurite [(Ru, Os)S-2], with a single osmiridium (Os-Ir alloy) grain also observed suggesting formation under high-temperature and low & fnof;S-2 conditions. Primary base metal mineral inclusions include millerite and pentlandite. Additionally, some chromite crystals contain single or multi-phase silicate inclusions, such as clinopyroxene, orthopyroxene, olivine, and amphibole. Parental melt compositions, calculated from Al2O3 and TiO2 contents of chromites, indicate that most high-Cr chromitites originated from boninitic melts, whereas intermediate chromitites and some high-Cr samples derived from melts with intermediate compositions. Trace element compositions of amphibole and clinopyroxene inclusions in the chromite crystals from the intermediate group further support crystallization from hydrous intermediate melts. It is proposed that the intermediate chromitite group formed from partial melts influenced by fluids from the subducted oceanic crust during the early stages of subduction initiation, while high-Cr chromitites originated from hydrous melts derived from a more depleted mantle wedge in later stages.
AtıfScopus3WoS4OpenAlex3İncele - MakaleAçık Erişim2025Scopus SJRQ2Could GSTP1, PTEN and NKX3.1 gene expression be novel markers in the relationship between prostate cancer and epigenetics?
Koçak, Tevfik; Acar-Tek, Nilufer; Yesil, Suleyman; Ergün, Mehmet Ali; Icer, Yusuf
Background: Although numerous treatment modalities exist for Prostate Cancer (PCa) with a complex pathophysiology, a significant worldwide health concern for males, early identification remains the paramount factor influencing disease prognosis. Proposed new biomarkers, including GSTP1, PTEN, and NKX3.1, may provide predictive and prognostic functions, hence enhancing the efficacy of PSA in diagnosing prostate cancer. Epigenetic variables associated with nutrition influence the blood gene expression levels of the new biomarkers GSTP1, PTEN, and NKX3.1. This study aimed to elucidate the correlation between nutrition-related epigenetic variables and the expression of the tumor suppressor genes GSTP1, PTEN, and NKX3.1 in benign prostate and prostate cancer patients. Methods: This study was conducted with 41 newly diagnosed prostate cancer and 42 benign prostate patients, all aged 40 years and older. Participants had specific anthropometric measurements taken, and seven-day food records were kept. Serum levels of novel biochemical markers GSTP1, PTEN, and NKX3.1 were measured using an Enzyme-Linked Immunosorbent Assay (ELISA) method. Expression analyses of tumor-protective GSTP1, PTEN, and NKX3.1 genes were performed on prostate tissues obtained from fresh prostate biopsies taken from the groups and were associated with nutritional status. Results: A significant relationship was found between the serum levels of GSTP1, PTEN, and NKX3.1, which are important in the formation and treatment of prostate cancer, and Gleason grade, tumor stage, and surgical margin status (p < 0.05). However, significant relationships were found between many macro and micronutrients obtained from the dietary pattern and effective in epigenetic pathways and GSTP1, PTEN, and NKX3.1 gene expressions (p < 0.05). Conclusions: The findings of this investigation corroborated the notion that prospective novel markers, including GSTP1, PTEN, and NKX3.1, may serve predictive and prognostic functions in prostate cancer, hence enhancing the efficacy of PSA in its diagnosis. Dietary trends may influence the optimization of many epigenetic processes. Targeted therapeutic nutritional interventions designed to enhance gene expression will facilitate the formulation of prostate cancer prevention methods.
- MakaleAçık Erişim2025Scopus SJRQ2Chromitites of Teskuduk and Nurata Ophiolites (Southern Tien Shan Belt, Uzbekistan): Geochemical characteristics and implications of chromitite genesis
Dönmez, Cahit; Aral, Zehra Deveci; Saka, Samet; Günay, Kurtulus; Yildirim, Nail; Yildirim, Esra; Yagcioglu, Kiymet Deniz; Maqsud, Isoqov; Movlanov, Jakhongir; Dovronovich, Mamarozikov Usmonjon
The Central Asian Orogenic Belt's ophiolites lack a full ophiolitic succession and instead occur as irregular fragments and slices in tectonic melanges and accretionary complexes. The Teskuduk and Northern Nurata ophiolites in Uzbekistan comprise extensively serpentinized mantle rocks that contain minor podiform chromitites, situated in the western area of the southern Tien Shan belt. Chromites in this region are found in a very limited area, and this study aims to determine the geochemical properties and formation environments of chromites by conducting geochemical studies on a limited number of recently discovered chromitites. In this context, mineral chemistry and platinum group element (PGE) geochemistry analyses were carried out on chromites. For Teskuduk chromitites, the Cr2O3, Al2O3, and TiO2 contents range from 53.2 to 55.7wt%, 11.1 to 12.7wt%, and 0.14 to 0.20 wt%, respectively, whereas for Nurata chromitites, the corresponding values range from 36.2 to 37.2 wt%, 23.1 to 30.2 wt%, and 0.10 to 0.30 wt%. The Teskuduk and Nurata chromitites contain a total average of 370 ppb and 117 ppb PGEs, respectively. They are classified as unfractionated chromitites, with low Pd/Ir ratios (0.03-0.20). These chromitite samples have chondrite-normalized PGE patterns that are identical to Cr-rich mantle-derived chromitites found in subduction-related ophiolites. Collectively, these data suggest that the Teskuduk ophiolites formed in a forearc setting, whereas the Nurata ophiolites evolved in a back-arc setting within the same oceanic branch.
- MakaleAçık Erişim2025Scopus SJRQ2Recurrent aphthous stomatitis, oxidative stress, and ischemia modified albumin: A cross-sectional study
Öztekin, Aynure; Öztekin, Coskun; Sahin, Humeyra Nursel; Karadeniz, Tuba Betul; Senel, Engin; Caliskan Atac, Damla; Savci, Unsal; Neselioglu, Salim; Erel, Ozcan
Recurrent aphthous stomatitis is an inflammatory disease characterized by painful ulcers on the oral mucosa. Oxidative stress is held responsible for the pathogenesis of this disease of unknown etiology. In oxidative stress, the balance between oxidant-antioxidant substances changes in favor of the oxidative side. Ischaemia modified albumin (IMA) is a new type of albumin. It occurs as a result of factors such as ischemic attacks and oxidative stress. The aim of the study was to compare IMA levels in patients with recurrent aphthous stomatitis with healthy volunteers and to investigate whether IMA has a diagnostic value in the disease. This cross-sectional study included 32 patients with recurrent aphthous stomatitis and 34 healthy volunteers of similar age and sex. Albumin and IMA levels were determined by spectrophotometric albumin cobalt binding assay in venous blood samples on the same day. IMA was expressed as absorbance unit. Receiver operating characteristic analysis was used to determine whether IMA values could be a diagnostic marker for prediction of disease. IMA values of the patient group were significantly higher than IMA values of the control group (P < .001). IMA was statistically significant in the prediction of recurrent aphthous stomatitis (P < .001). The discrimination power for IMA was very good (area under the receiver operating characteristic curve 95% CI = 0.952 [0.897-1.000]). Recurrent aphthous stomatitis, in which oxidative stress plays a role in the etiopathogenesis, is closely associated with high IMA levels. IMA levels may have diagnostic value as an indicator of oxidative stress in the disease.
- MakaleAçık Erişim2025Scopus SJRQ1A Dose-Dependent Study Examining Dexmedetomidine's Possible Effects Against Oxidative, Fibrotic, and Apoptotic Damage Induced by Radiation Exposure in Spleen Tissue
Beyazal Polat, Hatice; Yilmaz, Hamit; Kilinc, Kagan; Gülhan, Belemir; Yilmaz Rakici, Sema; Tümkaya, Levent
Objective: This study aimed to investigate the potential splenic tissue damage induced by radiotherapy (RT) and the potential protective effect of different doses of dexmedetomidine on this damage at the histopathological, immunohistochemical, and biochemical levels. Materials and Methods: In our study, Sprague Dawley rats were randomly divided into four groups: Control, Radiotherapy (RT; 8 Gy), RT + Dexmedetomidine 100 mu g/kg (RT-D100), and RT + Dexmedetomidine 200 mu g/kg (RT-D200). A single dose of 8 Gy radiotherapy was administered to each RT group. Spleen tissues were examined histologically with hematoxylin-eosin and immunohistochemically with anti-Caspase-3, anti-TGF-beta 1, and anti-TGF-beta 3 using light microscopy. TBARS and total thiol levels were also analyzed to assess oxidative stress and antioxidant capacity. Results: Histopathological results showed a significant decrease in white pulp diameter, decreased cellular density, and increased congestion in the red pulp in the RT group. Significant fibrosis, sinusoidal dilatation, vacuolization, and amyloid deposition were detected in the white pulp in the RT group. Regarding anti-caspase-3 immunoreactivity, strong positivity increased in the red pulp in the RT group, while a significant increase was observed in the white pulp in both the RT-D100 and RT groups. While the proportion of TGF-beta 1 immunopositive cells did not change significantly in the RT group, they increased significantly in both dexmedetomidine groups (especially RT-D200). TGF-beta 3 expression increased significantly only in the RT-D100 group. In biochemical analyses, TBARS levels increased significantly in the RT-D100 group. Total thiol levels decreased in the RT group and increased in the dexmedetomidine-treated groups. Conclusions: While RT caused histopathological damage and increased oxidative stress in spleen tissue, dexmedetomidine reduced this damage in a dose-dependent manner. The different immunohistochemical profiles of TGF-beta 1 and TGF-beta 3 suggest that these cytokines may have different functions in the spleen. 100 mu g/kg dexmedetomidine stimulates a regenerative response through TGF-beta 3, while 200 mu g/kg dexmedetomidine may provide immune regulation and antioxidative defense through TGF-beta 1.
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