Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(77)
- Merdan, Mehmet(73)
- Duran, Celal(54)
- Ozdes, Duygu(50)
- Baltaci, Cemalettin(45)
- Kaygusuz, Abdullah(45)
- Kulakaç, Nurşen(39)
- Ashyralyyev, Charyyar(38)
- Karsli, Orhan(37)
- Demir, Selim(36)
- Öztürk, Serkan(36)
- Dokuz, Abdurrahman(35)
- Turan, Ibrahim(35)
- Araz, Onur(33)
- Kandemir, Raif(31)
- Sipahi, Ferkan(30)
- Topal, Fevzi(30)
- Kurt, Kemal(28)
- Peker, Iskender(28)
- Arslan, Mehmet(27)
- Baltacı, Cemalettin(27)
- Maden, Nafiz(27)
- Ozturk, Samet(27)
- Aydin, Aydanur(26)
- Vural, Alaaddin(26)
- Bayrakdaroglu, Serdar(25)
- Kurnaz, Muammer(25)
- Reis, Hatice Catal(25)
- Akar, Zeynep(24)
- Aydin, Faruk(24)
- Gücer, Mehmet Ali(24)
- Topal, Meryem(24)
- Yolcu, Halil(24)
- Yücel, Cem(24)
- Anaç, Halil(23)
- Kankal, Murat(23)
- Ürkek, Bayram(23)
- Aliyazicioglu, Yuksel(22)
- Günen, Mehmet Akif(22)
- Tuncer, Metin(22)
Yayınlar
- MakaleAçık Erişim2019Scopus SJRQ4Presence of different bacterial species in thermal sources and novelty in their industrial enzyme productions
Albayrak, Seyda; Genc, Berna; Ozkan, Hakan; Taskin, Mesut; Adiguzel, Ahmet
In this study, one hundred and thirty isolates were isolated from water and sludge samples taken from hot springs located in different regions of Turkey. Among them, eleven isolates were chosen according to conventional (morphological, physiological and biochemical tests) and molecular methods (rep-PCR and 16S rRNA sequencing). These bacteria were then tested for their capability to produce valuable enzymes. As a result; species belonging to Bacillus, Anoxybacillus, Aeribacillus, Enterococcus, Exiguobacterium and Paenibacillus were identified. Test strains were found to have optimum reproductive potential at pH 5.0-9.0 and 15-65°C, usually at a concentration of 1.0-10.0% (w/v) NaCl. In addition, all thermotolerant bacteria were Gram, endospore (except E. profundum), catalase and oxidase (except E. faecium and E. profundum) positive, and rod-shaped (except E. faecium). It was observed that all isolates had a 99% similarity percentage as a result of 16S rRNA sequence analysis. All of the isolates were capable of producing industrially important enzymes moreover, eight of them could produce at least two of these enzymes. Test strains had high potential of industrial enzyme production, and the enzymes from these thermo-tolerant isolates will be widely used in biotechnological processes.
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İncele - Derleme MakaleYalnız künye2019Scopus SJRQ2Automation in the Mining Industry: Review of Technology, Systems, Human Factors, and Political Risk
Rogers, W. Pratt; Kahraman, M. Mustafa; Drews, Frank A.; Powell, Kody; Haight, Joel M.; Wang, Yaxue; Baxla, Kritika; Sobalkar, Mohit
In the opinion of these authors, technology alone can never give an organization an edge over competitors or provide an industry step change. However, history has shown that technology applied with correct logistics and strategy makes a significant difference. Never has the minerals industry faced such daunting challenges and been in such need of a step change. Application of autonomous systems has been steadily increasing in the minerals industry. Automation technology has changed the mining value chain from exploration to mineral processing and refining. The future state will only see additional in-roads of automation into more processes and the whole system design. To better understand the near-future potential of automation, it is useful to explore and review the current state of automation in minerals development. A review of the state of automation research is given. The review will consider three critical areas: automation technology, system’s engineering and management processes around automation, and the role of human factors engineering in automated and semi-automated systems. The review ends with a discussion on the social and political risks of automation in terms of shared value and sustainable development.
AtıfScopus95WoS70OpenAlex75İncele - MakaleYalnız künye2019Scopus SJRQ2Exploring the value of using data: a case study of continuous improvement through data warehousing
Rogers, W. Pratt; Kahraman, M. Mustafa; Dessureault, Sean
The mining industry is adapting data-rich technology. Data management processes and infrastructure require additional investment which, can be difficult to justify. A valuation model for data management infrastructure would necessitate modelling the ‘use’ of data and quantifying the value and the likelihood of success of improvement initiatives. A model is presented which can assess the impacts of a data-driven initiative. The initiatives are shown to be the foundation of improved shift coordination resulting in significant and sustained operational improvements. This paper aims to illustrate the value of using data from source systems in mining operations.
AtıfScopus9WoS8OpenAlex11İncele - KitapYalnız künye2019Contemporary Debates on Politics and Public Administration in the Postmodern Era
Ugur, Ömer; Dogan, Kadir Caner
The volume provides a collection of articles on current debates in the fields of politics and public administration. The authors deal with frequently mentioned concepts of our era in political and public administration sciences.
AtıfScopus1OpenAlex6İncele - MakaleAçık Erişim2019Scopus SJRQ2FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2
Abada, A.; Abbrescia, M.; AbdusSalam, S. S.; Abdyukhanov, I.; Fernandez, J. Abelleira; Abramov, A.; Aburaia, M.; Acar, A. O.; Adzic, P. R.; Agrawal, P.
In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with today's technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics.
AtıfScopus989WoS933OpenAlex919İncele - MakaleAçık Erişim2019Scopus SJRQ2HE-LHC: The High-Energy Large Hadron Collider Future Circular Collider Conceptual Design Report Volume 4
Abada, A.; Abbrescia, M.; AbdusSalam, S. S.; Abdyukhanov, I.; Abelleira Fernandez, J.; Abramov, A.; Aburaia, M.; Acar, A. O.; Adzic, P. R.; Agrawal, P.
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries.
AtıfScopus210WoS84OpenAlex196İncele - MakaleAçık Erişim2019Scopus SJRQ3Prostate volume effect on Gleason score upgrading in active surveillance appropriate patients
Çamur, Emre; Coskun, Alper; Kavukoglu, Ovunc; Can, Utku; Kara, Onder; Çamur, Arzu Develi; Sarica, Kemal; Narter, Kamil Fehmi
Introduction: Gleason Score (GS) upgrading rates in the literature are reported to be around 33-45%. The relationship between prostate volume and GS upgrading should be defined, aiming to reduce upgrading rates in patients with low risk groups who are eligible for active surveillance (AS) or minimally invasive treatment, by varying biopsy cores, or lengths of cores according to prostate volumes. In this regard, the aim of our study was to establish the relationship between prostate volume and GS upgrading. Materials and methods: We retrospectively analyzed the medical records of 78 patients, who were appropriate for AS between 2011-2016 at our hospital. Inclusion criteria were patient age under 65 years, PSA level under 10 ng/ml, GS (3 + 3) or (3 + 4), and 3 or less positive cores, clinical stages <= T2. GS increase in radical prostatectomy specimen was considered as 'upgrading' and in addition, score reported by biopsy as 3 + 4 but in surgical specimen as 4 + 3 were also considered as 'upgrading'. The effect of prostate volume on Gleason grade upgrading was examined by calculating upgrading rates separately for patients with prostate volume 30 ml or less, those with 30 to 60 ml, and those over 60 ml. Results: As a result of the analysis of the data, upgrading was seen in 35 (44.8%) of 78 patients included in the study. In the cohort mean prostate volume was 49.8 (+/- 26.3) ml. Twenty-two patients (28.2%) had prostate volume 30 ml or less, 34 (43.6%) 30 to 60 ml, and 22 (28.2%) 60 ml or more. The patients were divided into two groups as those with and without GS upgrading. Between the groups prostate volume and prostate volume range (0-30/31-60/> 60) were not significantly different (p value > 0.05). Conclusions: Gleason grade upgrading causes patients to be classified in a lower risk group than they actually are, and may lead to inappropriate treatment. This condition has a direct effect on the decision of active surveillance. Therefore, it is important to define the factors that can predict GS upgrading in active surveillance appropriate patients. In this study, we found that prostate volume has no significant effect on upgrading in active surveillance appropriate patients.
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İncele - MakaleAçık Erişim2019Scopus SJRQ2Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS
Gulcin, Ilhami; Kaya, Ruya; Goren, Ahmet C.; Akincioglu, Hulya; Topal, Meryem; Bingol, Zeynebe; Cakmak, Kader Cetin; Sarikaya, Sevim B. Ozturk; Durmaz, Lokman; Alwasel, Saleh
Ethanolic (EEC) and aqueous (WEC) extracts of cinnamon (Cinnamomum verum) were evaluated for their antioxidant profiles by eight distinguished bioanalytical antioxidant methods. Their inhibitory effects were tested against some enzymes including acetylcholinesterase, butyrylcholinesterase, alpha-glycosidase and alpha-amylase, which linked to different diseases. Additionally, the antioxidant properties were determined and polyphenolic compositions of the both extracts were evaluated by LC-MS/MS analysis. According to the LC-MS/MS experiments, thirteen compounds were found in WEC and EEC. Also, p-hydroxybenzoic acid (321.1 mg/kg extract), p-coumaric acid (291.4 mg/kg extract), and pyrogallol (142.4 mg/kg extract) were found to be the most abundant ingredients in the WEC. On the other hand, pyrogallol (264.3 mg/kg extract), ferulic acid (224.7 mg/kg extract) and p-coumaric acid (170.2 mg/kg extract) were found as the most plentiful chemicals in the EEC. For the estimation of the antioxidant capacities of the both extracts (WEC and EEC), DPPH center dot and ABTS(center dot+) scavenging activities, as well as Fe3+-Fe2+, and Cu2+-Cu+ reducing assays were studied. The IC50 values of the WEC and EEC indicated that they were potent effective DPPH center dot (21. 25 and 15.71 mu g/mL) and ABTS(center dot+) (6.52 and 5.79 mu g/mL) scavengers, as well as AChE (221.33 and 110.26 mu g/mL), BChE (461.69 and 94.93 mu g/mL), alpha-glycosidase (206.86 and 220.00 mu g/mL) and alpha-amylase (189.86 and 200.86 mu g/mL) inhibitors. As a conclusion, both EEC and WEC had rich phenolic contents and demonstrated effective anticholinergic, antidiabetic and antioxidant effects.
AtıfScopus202WoS172OpenAlex178İncele - MakaleYalnız künye2019Scopus SJRQ1A novel niosome formulation for encapsulation of anthocyanins and modelling intestinal transport
Fidan-Yardimci, Melike; Akay, Seref; Sharifi, Fatemeh; Sevimli-Gur, Canan; Ongen, Gaye; Yesil-Celiktas, Ozlem
The bioavailability of drugs can be improved by regulating the structural properties, particularly lipoid systems, such as niosomes, can increase cellular uptake. Herein, we optimized double emulsion and niosomal formulations for encapsulating anthocyanin-rich black carrot extract. Nanoparticles obtained by selected formulation were characterized in terms of morphology, particle size, drug encapsulation efficiency, in vitro release and cytotoxicity. The optimum conditions for niosomal formulation were elicited as 30 mg of cholesterol, 150 mg of Tween 20 and feeding time of 1 min at a stirring rate of 900 rpm yielding the lowest average particle size of 130 nm. In vitro release data showed the majority of the encapsulated anthocyanins were released at the end of 10 h. A mathematical model was developed to estimate the absorption of anthocyanins released from niosomes and cytotoxicity was assessed against neuroblastoma. Overall, these findings suggest that niosomal vesicles might be suitable delivery systems for anthocyanins.
AtıfScopus67WoS61OpenAlex68İncele - MakaleAçık Erişim2018Enhancement of bioavailable micronutrients and reduction of antinutrients in foods with some processes
Hendek, Muge; Bektaş, Müberra
The most of plant foods, nuts and cereals contain antinutrient compounds. They reduce to mineralbioavailability and protein absorption of foods thanks to their chelating properties. They causes tomicronutrient malnutrition and mineral deficiencies. The micronutrient malnutrition is a widespreadglobal health problem not only in developing but also in many countries. Increasing micronutrientintake in food through food processing based approaches is a sustainable method of prevention ofmicronutrient malnutrition which should be achieved through food diversification. There are traditionaland technological methods that provide reducing of antinutrient compounds.The pretreatmentand processing techniques as soaking, fermentation, germination, debranning, and autoclaving areeven traditional methods which use generally in consumption of foods.Removing antinutrients, thebioavailability of some cation (Ca, Fe and Zn) and the absorption of proteins make to increase andconsequently nutrition value of food increase. It is possible to reduce antinutrient factors by usingdomestic or industrial basic food processing techniques alone or in combination.This review focusedon various methods to reduce antinutrients in food such as phytic acid, tannin, and oxalate in foodgrain to improve nutritional quality of foods.
AtıfOpenAlex115TR Dizin5
İncele - MakaleYalnız künye2018Ahşap Koruyucuların Sapsız Meşe (Quercus Petreae L.) Ağacının Yanma Özelliklerine Etkileri
Atar, Musa; Yasar, Sekip Sadiye
Bu çalışma, ahşap koruyucu ile emprenye edilmiş, üst yüzey işlemleri uygulanmış sapsız meşe (Quercus petraea L.) odununun yanma özelliklerini belirlemek amacıyla yapılmıştır. Bu maksatla ASTM–E 160-50 ‘ye göre hazırlanan sapsız meşe örnekleri ASTM-D 1413-76 ‘ya göre tanalith-E ve wolmanit-CB ile emprenye edilmiş, ASTM-D 3023’ e göre sentetik ve su bazlı vernik ile verniklenmiştir. Yanma deneyi, alev kaynaklı yanma (CWF), kendi kendine yanma (CWOF)ve kor halde yanma (ECP) olmak üzere 3 aşamada gerçekleştirilmiştir. Yanma deneyi ile ağırlık kaybı, toplam yanma süresi, yıkılma süresi ve CWF, CWOF ve ECP periyotlarındaki yanma sıcaklık değerleri belirlenmesi amaçlanmıştır. Sonuç olarak; emprenye uygulamaları toplam yanma süresini %15-18 arasında arttırmış, yıkılma süresini azaltmıştır. Vernik çeşitlerin tam tersi sonuçlar elde edilmiş, toplam yanma süresi %19-21 arasında azalmış, yıkılma süresi %10-22 arasında artmıştır. Alev kaynaklı aşamasında yanma sıcaklığı en yüksek su bazlı vernikli (490 o C), en düşük vernik uygulanmayan örneklerde (458 o C), alev kaynağı olamadan kendi kendine yanmada en yüksek su bazlı vernikte (572 o C), en düşük sentetik vernik uygulanan örneklerde (544 o C), kor halde yanmada en yüksek sıcaklık vernik uygulanmayan örneklerde (306.5 o C), en düşük sentetik vernik uygulanan örneklerde (262.7 °C) elde edilmiştir.
AtıfTR Dizin1İncele - Derleme MakaleYalnız künye2018Özel Girişimciliğin Başarısı Olarak Uşak Şeker Fabrikası
Damlıbağ, Fatih
Nuri Şeker Uşak Şeker Fabrikasını 1926’da kurdu. Pancardan Türk şekerini üretmeyi hedeflemişti. Böylece Türk halkının bu ihtiyacını kolayca sağlamak istemişti. Kendisi ayrıca fakir köylülere düzenli bir gelir kaynağı sağlamayı planlamıştı. Bir şirket kurdu ve fabrika için sermaye toplamaya başladı. Çekoslovak Skoda firması fabrikaya teknoloji sağladı. Açılıştan sonra, Uşak Şeker Fabrikası su sağlama ve zirai haşere sorunlarıyla karşılaştı. Nuri Şeker ayrıca yeni şeker pancarı ziraatını köylülere öğretmek zorundaydı. Bütün zorluklara karşı, fabrika çalışmaya başladı ve şeker üretimi sürekli artmaktaydı. Fakat Nuri Şeker finansal zorluklarla karşılaştı. Çünkü şeker üretimindeki tecrübe yılları fabrikanın borçlarını arttırdı. Bu borçların sonucunda, hükümet fabrikanın şirketini tasfiye etmeye karar verdi. Kamulaştırma 6 Ağustos 1931’de gerçekleştirildi. Tasfiye sürecinde halk hissedarlarının hakları ana tartışma noktası oldu. Sonunda, hükümet halk hissedarlarının hisselerinin tam karşılığını ödemeye karar verdi. Neticede, özel girişimcilerin bağlantıları Uşak Şeker Fabrikasından tamamen kopartıldı.
- MakaleYalnız künye2018Nine new records from high mountain lakes (Artabel Lakes Nature Park, Gümüşhane/Turkey) for the freshwater diatom flora of Turkey
Akar, Bülent; Şahin, Bülent
This study was carried out in 17 high mountain lakes and a pond in the Artabel Lakes Nature Park (Gümüşhane)on August 15, 2013 and August 13, 2016. In the present study, epipelic, epilitic and epiphytic algal flora of lakes weredetermined and a total of 95 taxa were recorded belonging to Bacillariophyta division. 9 of the taxa belonging toBacillariophyta were determined to be new records for the freshwater diatom flora of Turkey. These taxa were identifiedas Aulacoseira lacustris (Grunow) Krammer f. tenuior Houk, Klee and Passauer, Orthoseira roeseana (Rabenhorst)Pfitzer, Cyclotella ambigua Grunow, Planothidium distinctum (Messikommer) Lange-Bertalot, Psammothidiumhelveticum (Hustedt) Bukhtiyarova and Round, Diploneis petersenii Hustedt, Frustulia crassinervia (Brébisson exW.Smith) Lange-Bertalot and Krammer, Eunotia mucophila (Lange-Bertalot, Nörpel–Schempp and Alles) LangeBertalotand E. paludosa Grunow
AtıfTR Dizin7İncele - MakaleAçık Erişim2018The Effect of the Online News on Tourism
Ayyildiz, Hasan; Dişli Bayraktar, Eda; Kutlu, Didem
Due to the technological developments, people are able to quickly reach the information and the news about destinations where they have planned to go on their holidays. Online news websites are important and reliable tools which deliver up-to-date information about a destination to broad masses. It is indisputable that the media is a significant influence on public awareness, tourist purchase decision, destination image and tourist behavior. A tourist who chooses a holiday destination decides among countless destinations according to the information he receives from various sources. Therefore, in this study, the news in the two foreign online news sites are interpreted according to the touristic arrival statistics from the Ministry of Culture and Tourism. The two countries to be included in the study, Germany and England, were selected among the countries that sent the most tourists to Turkey. In these countries, news web sites with the highest number of daily visitors were determined and the news related to Turkey in the 7 years period between 2010 and 2016 were analyzed by content analysis.
AtıfOpenAlex5TR Dizin1İncele - MakaleAçık Erişim2018Investigation of similarities and differences of turkish and spanish cuisine cultures
Akyürek, Suat
Eating-drinking is a biological need as well as consist of materialelements satisfying the needs of societies and individuals. Eating-drinking habit which is an indispensable element of the culture, assumesmany functions from the past until now such as being a status symbolin society, means of communication, means of spare time andentertainment and making different cultures closer. The cuisine cultureare the accumulations which contain the food/beverages that a nationconsumes, preparation of such food/beverages and the tools andmaterials used in protection of them. A formation of a cuisine culture ispossible by ages of accumulation and interaction. Turkish and Spanishcuisines are one of the richest cuisines of the world in terms of their longstanding historical past, rich content and cultural features they possess.In this context, it is important to review similar and different aspects ofthese two rich cuisine cultures. In this regard, it is aimed to revealsimilarities and differences between Turkish cuisine culture and Spanishcuisine culture. In addition to this, in the food and beverage field whichis one of the leading sectors of today, cuisine culture of the region thattourists visit should be known in order to give better service to tourists.Accordingly, secondary sources were used during data collection processin this study which is designed as literature review. Besides, Turkish andSpanish cuisine cultures were observed, similar and different aspectswere tried to be identified. According to the results of the research, it isseen that there are many similarities between Turkish and Spanishcuisine.
AtıfOpenAlex4TR Dizin4İncele - MakaleYalnız künye2018Sugar production investments in turkey during post 1929 economic crisis period
Damlıbağ, Fatih
During the 1929 Economic Crisis, prices of agricultural products decreased muchmore than industrial products. Turkey, as an agricultural product exporter could not affordits importation under these new conditions. For the financial structure of Turkey, selfsufficiencywas seen as the most convenient solution. In this period, the Turkish governmentaimed at importing substitution in sugar production. But for achieving this, Turkey neededsome additional investments. For the capital needs of these investments, governmentprimarily evaluated foreign contribution. But Turkish banks provided necessary capital tosugar industry, with the leadership of İş Bankası. German and Czechoslovak contributionalso supplied machinery and technical assistance to Turkish sugar industry. Governmentdeeply investigated possible investment places, to reach the most appropriate conditions.At last, Turkey founded two new sugar factories with their own financial sources in 1933and 1934. Eskişehir Sugar Factory was the third factory in Turkey and Turhal Sugar Factorybecame fourth investment in this field. Government unified the whole sugar production ofTurkey in 1935, in order to reduce production costs. From this date, Turkey experienced rapidexpansion in both beet agriculture and sugar industry. In this article, the state centered sugarproduction investments were evaluated under the different financial conditions of the 1929Economic Crisis. For the time period, subject would be investigated up to the early 1940’s.
AtıfTR Dizin1İncele - MakaleAçık Erişim2018Picea orientalis kozalağının antioksidan ve antiradikal özelliklerinin belirlenmesi
Topal, Meryem
Metabolizmada oluşan reaktif oksijen türleri engellenmediği sürece, DNA, protein, karbohidrat ve lipitlerde yapısal bozulmalar meydana getirir. Buna bağlı olarak hücre membranının hem stabilizesi ve hem de fonksiyonları bozulur ve birçok dejeneratif hastalıklar meydana gelir. Önceki çağlarda insanlar sağlık sorunlarını çözmek için de bitkisel tedavilere başvurmuştur. Günümüzde özellikle bilimsel olarak çalışmalar artmış özellikle alternatif tıp olarak da yaygınlık göstermiştir. Fenolik bileşik içeren bitkiler doğal antioksidan olarak genellikle kullanılmaktadır. Bu bileşikler serbest radikallerin yol açtığı reaksiyonları durdurarak veya engelleyerek kalp, kanser, ve akciğer hastalıkları gibi hastalıkların oluşumuna engellerler. Antioksidanlar, biyomoleküllerin oksidasyonunu engelleyen veya tamamen durduran maddeler olarak bilinir ve oldukça yaygın bir kullanım alanına sahiptirler. Doğu ladin, çamgiller familyasında bulunan bilimsel adı P. orientalis’dir. Yapılan bu çalışmada doğu ladin kozalağının etanol ekstreleri kullanılarak antioksidan kapasitesinin belirlenmesi hedeflenmiştir. Bu amaçla demir indirgeme kapasiteleri ve bakır indirgeme kapasiteleri, ABTS radikal giderme aktiviteleri ve DPPH radikal giderme aktiviteleri, total fenolik bileşik miktarlarını ve flavonoit bileşik miktarlarını belirleme gibi in vitro şartlarda farklı biyoanalitik metotlar ile antioksidan ve antiradikal özellikleri belirlendi. P. orientalis kozalağının DPPH radikal giderme aktivitesi için IC 50 değeri 24,75 μg mL -1 , ABTS radikal giderme aktivitesi için ise 13,42 μg mL -1 olarak tespit edildi. Buna göre yapılan metotlarda yüksek antioksidan kapasitesine sahip olduğu belirlendi.
AtıfOpenAlex4TR Dizin1İncele - MakaleYalnız künye2018Perception Of Disease, Quality Of Life, Self-Care Management In Chronic Illness
Doğan, Melike Demir; Tosun, Esen; Tek, Ahmet Duran
Chronic illnesses with prolonged and slow progression are a rising problem in health care and the number of individuals with one or more chronic illnesses is increasing day by day. This cross-sectional study was conducted to determine the relationship between the perception of disease, self-care management, and quality of life in individuals with chronic illness. The sample of the study consisted of 127 patients who were hospitalized in Internal Medicine and Surgical clinics, had at least one chronic illness and agreed to participate in the study. The data were collected with personal information form, illness perception questionnaire (IPQ), self-care management scale in chronic illnesses (SCMP-G Questionnaire), and EQ-5D-5L general quality of life questionnaire.As a result of the statistical analysis, scores of the self-guarding subscale of self-care management scale were seen to be significantly higher in women than men. Self-care management of the patients with respiratory disease was significantly higher than diabetic patients. As a result of the present study, it was observed that the female patients had better self-care management compared to the male patients. However, the men were found to have a better quality of life than the women. Patients with respiratory disease had a better self-care management than diabetic patients.
AtıfTR Dizin6İncele - MakaleAçık Erişim2018Market Structure of the Turkish Pharmaceutical Industry
İpek, Egemen; Ipek, Ozlem
The market structure of the Pharmaceutical Industry, which has an extremelyimportant both socially and economically position, is carefully monitored by regulatoryauthorities. The consantration of pharmaceutical companies tends to adversely affectconsumer welfare as well as resource distribution in the economy. The competitivestructure of the markets is determined by the concentration indices. For these reasons,in this study the market concentration ratios of the pharmaceutical sector in Turkey arecalculated by using concentration measures such as Concentration Ratio; HerfindahlHirschman; Hall-Tideman; Rosenbluth; Comprehensive Industrial Concentration;Hannah-Kay; Hause and the Entropy measure with the annual sales revenue data of thecompanies in the sector for the 2009-2016 period.According to the results,pharmaceutical sector in Turkey has a low concentrated market structure. In addition,the Rosenbluth index presents the most consistent results for the Turkishpharmaceutical sector, which consists of hundreds of small companies having marketsshares of 7% at the highest.
AtıfOpenAlex8TR Dizin6İncele - MakaleAçık Erişim2018Antidiabetic Potential: Effect of Resorcinol on α-Glycosidase and α-Amylase Enzymes
Topal, Fevzi
The vast majority of the carbohydrates in the biomolecule class are formed by photosynthesis using sunlight. One of the important enzymes in this class is α-glycosidase. This enzyme converts complex carbohydrates to monosaccharides. On the other hand, another important enzyme species is the α-amylase enzyme. Which directly related to starch. Starch is a type of polymer formed by the oxygen binding of glucose units to each other at the C1 position with glycosidic bonds. α-Amylase is an enzyme that catalyzes the hydrolysis of glycosidic bonds in starch, and this enzyme is purified from a wide variety of animals, plants, and microorganisms. Resorcinol, a phenol derivative, is an important organic chemical substance in the production of textile, medicine, hair dye, plastic and agricultural products of many industrial materials. Resorcinol, a phenol derivative, is present as white crystals, and resorcinol consists of two hydroxyl molecules attached to the benzene ring, and also was defined as α-glycosidase and α-amylase inhibitor to detect antidiabetic properties. Resorcinol was used as 𝛼-glycosidase and 𝛼-amylase inhibitor. Accordingly, IC50 values of α-amylase and α-glycosidase were calculated as 1.34 μM and 77.00 nM, respectively. On the other hand, Ki value for α-glycosidase was found as 30.16 nM. It has been observed that α-amylase and α-glycosidase enzymes can inhibit by resorcinol compound. It has the properties of inhibiting carbohydrate absorption by inhibiting α-glycosidase enzymes in the small intestine. For both metabolic enzymes, resorcinol may be preferred as an inhibitor. In this case, resorcinol may be used as an inhibitor against to healty problems like Diabetes mellitus and antiobesity.
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