Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(64)
- Merdan, Mehmet(47)
- Baltaci, Cemalettin(35)
- Kulakaç, Nurşen(28)
- Duran, Celal(27)
- Ozdes, Duygu(24)
- Turan, Ibrahim(24)
- Demir, Selim(23)
- Türkkan, Tuğba(22)
- Bayrakdaroglu, Serdar(21)
- Topal, Fevzi(21)
- Öztürk, Serkan(21)
- Ürkek, Bayram(21)
- Gücer, Mehmet Ali(20)
- Akar, Zeynep(19)
- Kaygusuz, Abdullah(19)
- Topal, Meryem(19)
- Anaç, Halil(18)
- Aydin, Aydanur(18)
- Batan, Nevzat(18)
- Erata, Hüseyin(18)
- Tuncer, Metin(18)
- Akyürek, Suat(17)
- Baltacı, Cemalettin(17)
- Karimullah, Suud Sarim(17)
- Acet, Tuba(16)
- Akar, Bülent(16)
- Ashyralyyev, Charyyar(16)
- Düzgün, Azer Özad(16)
- Hintistan, Sevilay(16)
- Yılmaz, Coşkun(16)
- Aliyazicioglu, Yuksel(15)
- Kaya, Hacer(15)
- Kurnaz, Muammer(15)
- Kurt, Kemal(15)
- Ozden, Talat(15)
- Yilmaz, Coskun(15)
- Yuksel, Ferhat(15)
- Yücel, Cem(15)
- Öz, Mehmet(15)
Yayınlar
- MakaleAçık Erişim2016New Communication Technologies, Local Journalism and the Perception of Locality
Özcan, Ali
Studies on local journalism as an important element of participatory democracy generally focus on the history of the local press, the financial insufficiencies of local newspapers as well as technical/technological incompetency that occurs as a result of these factors. This research analyzes local newspapers with a new scientific point of view by focusing on the perception of locality as a mental projection of geographical constraint. Perspectives regarding the transformations on perceptions of locality as a result of the disappearance of time and space constraints due to new communication technologies, and the opportunities that new communication environments offer to local newspapers will be provided. Moreover, the ways in which local newspapers reflect on locality with their printed versions under time and space constraints will be analyzed. The research scope of the study has been limited to 15 newspapers in Konya. Structured interviews and content analysis methods were used for data collection and analysis.
- MakaleAçık Erişim2016Scopus SJRQ2Mechanical Bowel Preparation Does Not Affect Anastomosis Healing in an Experimental Rat Model
Piroglu, Isilay; Tulgar, Serkan; Thomas, David Terence; Cakiroglu, Basri; Piroglu, Mustafa Devrim; Bozkurt, Yasin; Gergerli, Ruken; Ates, Nagihan Gozde
Background: Mechanical bowel preparation before colorectal surgery is commonly performed, but its benefits are controversial. The aim of this study was to compare the effects of mechanical bowel preparation on healing of colonic anastomosis and tissue strength. Material/Methods: After institutional review board approval, 20 adult Wistar albino rats were randomly divided into 2 groups of 10 animals each. Mechanical bowel preparation including sodium phosphate was performed on the experimental group via a feeding tube, whereas no bowel preparation procedures were performed on the control group. Transverse colon resection and anastomosis were performed on all rats under general anaesthesia. On postoperative day 5, re-laparotomy was performed and the anastomotic areas were resected. Animals were killed, after which bursting pressure and tissue hydroxyproline concentrations were measured, histopathological examination was performed, and we evaluated and compared the results. Results: There were no differences between control and experimental groups in bursting pressure, tissue hydroxyproline concentrations, or histopathological examination results (P>0.05). Conclusions: Our study demonstrated no significant difference between bursting pressures, tissue hydroxyproline levels, or modified wound healing score at postoperative day 5 between rats undergoing and not undergoing mechanical bowel preparation. Mechanical bowel preparation is not essential for healing or strength of colonic anastomosis in rats.
AtıfWoS5
İncele - MakaleAçık Erişim2016Scopus SJRQ4Ultrasonographic assessment of the shoulder in patients with carpal tunnel syndrome
Mansiz Kaplan, Basak; Yagci, Ilker; Akdeniz Leblebicier, Merve
Objectives: To detect the causes of shoulder pain with shoulder ultrasonography in patients with carpal tunnel syndrome (CTS) and compare the findings of the patients with CTS to healthy controls. Patients and Methods: Patients with CTS and healthy controls were evaluated clinically, electrophysiologically. and ultrasonographically by three masked researchers. Electrophysiological assessment consisted median and ulnar nerve conduction studies (NCS). In ultrasonographic assessment, cross-sectional areas of the median nerve were measured at hamatum hook, psiform bone, radio-ulnar joint levels. Shoulder joint, axial and longitudinal biceps tendon, subscapularis tendon, supraspinatus tendon, infraspinatus tendon, rotator cuff, acromioclavicular joint were evaluated by a standardized protocol. Results: The study was completed with 30 patients with CTS and 30 healthy subjects. The presence of shoulder pain in the last week was 53.3% in the CTS group and 30% in the control group but there was no statistically significant difference between the groups (p=0.16; p>0.05). Subdeltoid bursitis was significantly more common in CTS group when compared to the control group (p=0.03) in ultrasonographic assessment, and there was no significant difference between the two groups for other parameters. Conclusion: Shoulder pain and subdeltoid bursitis were common in patients with CTS however, shoulder pain was not directly related to shoulder problems alone. Central sensitization may play a role for shoulder pain rather than shoulder problems.
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2016Lighter Ingestion as an Uncommon Cause of Severe Vomiting in a Schizophrenia Patient
Atayan, Yahya; Cagin, Yasir Furkan; Erdogan, Mehmet Ali; Bilgic, Yilmaz; Bestas, Remzi; Harputluoglu, Murat; Seckin, Yuksel
Background. Foreign bodies in the gastrointestinal tract are important morbid and mortal clinical conditions. Particularly, emergency treatment is required for cutting and drilling bodies. The majority of ingested foreign bodies (80-90%) leave gastrointestinal tract without creating problems. In 10-20% of cases, intervention is absolutely required. Less than 1% of cases need surgery. In this paper, we present a schizophrenia patient who swallowed multiple lighters. Case. A 21-year-old male schizophrenic patient who uses psychotic drugs presented to the emergency department with the complaints of abdominal pain, severe vomiting, and inability to swallow for a week. His physical examination revealed epigastric tenderness. A plain radiograph of the abdomen revealed multiple tiny metallic densities. Gastroscopy was performed. The lighters were not allowing the passage, and some of them had penetrated the gastric mucosa, and bezoars were observed. One lighter was extracted with the help of the polypectomy snare. Other lighters as a bezoar were removed by surgery. Conclusion. Excessive vomiting of swallowed foreign bodies in the etiology of psychotic patients should be kept in mind. Endoscopic therapy can be performed in the early stages in these patients, but in the late stage surgery is inevitable.
AtıfWoS2OpenAlex2İncele - BildiriAçık Erişim2016Analyzing restrictive elements of leisure time physical activities (Gumushane University sample)
Songün, Yesim; Albayrak, Ahmet Yilmaz; Katkat, Dursun; Bayrakdaroglu, Serdar; Can, Ibrahim; Gunduz, HB; Masal, E; Caliskan, H
The purpose of this study is to determine the causes which restrict joining leisure physical activities of academic and administrative staff working at University of Gumushane. 236 academic and 169 administrative, in total 405 person participated voluntarily in the study. Leisure time Physical Activity restrictor developed by Ocal (2012), were used as data collector. Descriptive statistics, T-test (Independent Sample Test) and Tukey test from multiple comparison tests were used in study. Consequently, it can be suggested that physical activities of Academic and Administrative Staff at Gumushane University, were influenced by gender, age, marital status, personal status and sport status.
AtıfOpenAlex1İncele - MakaleAçık Erişim2016Evaluation of forest management plans in conjunction with the cadastral information: The case of Agva and Beykoz, Istanbul
Cakir, Gunay; Guler, Alptug; Zengin, Hayati; Degermenci, Ahmet Salih
Determination of land ownership and boundaries is one of the most important purposes of the urban and rural land laws. There can be some boundary problems while preparing forestry area of any urban area when there is not consistency between the borders constructed by different state organizations like land cadastre, forest cadastre and forest management and planning teams. This study aims to illustrate these conflicts in forestry applications process of two different areas (Agva and Beykoz) having different characteristics. The study was carried out in Agva and Beykoz districts in the province of Istanbul and focused on the integration in the land and forest cadastral systems. The Beykoz and Agva Forest Planning Units have different characteristics in terms of population (urban and rural) and social impacts. Analyses of the data obtained from the field studies which it was utilized for the investigation of the data obtained from various base maps, were carried out using GIS software. Many inhabitants of the villages in the Agva Planning Unit had migrated from the district. Thus, in accordance with Boundary Law number of 6831 part of 2/B some parcels of villages in Agva were determined to be acting forest and were reassigned as forest land. In Beykoz, however, areas of this nature were few and the destruction of the forests was great. The spatial analysis of the study made it possible to remove discrepancies occurring in the cadastral situation by preparing forest management plans. Consequently, if land cadastre and forest cadastre units carry out work in coordination to determine the cadastral situation, a basis for forest management plans can be established and cadastral problems greatly reduced.
- MakaleAçık Erişim2016Scopus SJRQ2Comparison of flow behavior and physicochemical characteristics of low-cholesterol mayonnaises produced with cholesterol-reduced egg yolk
Yüceer, M.; Ilyasoǧlu, H.; Özçelik, B.
Egg yolk is common functional ingredient in food production, mainly in mayonnaise as an emulsifier. Egg yolk cholesterol was removed using β-cyclodextrine, treated with α-Amylase, and low-cholesterol mayonnaise produced. The flow behavior of cholesterol-reduced mayonnaise was investigated at different cholesterol-reduced egg yolk and xanthan gum content. The aim of this study was to evaluate the effects of different formulations at various percentages of egg yolk (EY; 4 and 6 percent by weight) and xanthan gum (XG; 0.5 and 0.7 percent by weight) on flow behavior and physicochemical properties of reduced-fat and low-cholesterol mayonnaise prepared with cholesterol-reduced liquid egg yolk and to obtain suitable model for mayonnaise formulations. The aim of the study was to develop a reduced-fat and lowcholesterol mayonnaise with properties similar to those of typical mayonnaise in the market. For this purpose, four reduced-fat and low-cholesterol mayonnaise formulations were prepared in the laboratory using cholesterol-reduced EY. They were compared with a commercial mayonnaise from a local market as a control sample. According to results, color parameters and flow behaviors of the samples compared with the control sample indicated that the samples had higher values of lightness and yellowness, and presented lower values of yield stress and flow behavior index and higher values of consistency coefficient with respect to the commercial product, except recipe that included 6% of EY and 0.7% of XG, which exhibited similar values to the typical commercial one in the market. The Herschel Bulkley model was employed in order to evaluate the effect of EY and XG ratios on mayonnaise rheological behavior. In general, the results obtained suggest that the recipe with EY (6 wt%) and XG (0.7 wt%) had better rheological characteristics and physicochemical properties those prepared with various formulations, maintaining the reduced-fat and low-cholesterol mayonnaise prepared with β-cyclodextrine-Treated cholesterol-reduced EY. It can be interpreted that the developed product may have potential use in industrial application.
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İncele - Kitap BölümüAçık Erişim2016The effects of an accounting information system on the institutionalisation level of enterprises
Cam, Handan; Tosunoglu, Busra
An accounting information system (AIS) is a system of collecting, storing, and processing financial and accounting data that is used by decision makers. An accounting information system is generally a computer-based method for tracking accounting activity in conjunction with information technology resources. The purpose of this study is to determine the effects of an accounting information system on the institutionalisation level of enterprises. In this regard, a model has been developed and tested. Five hypotheses were constituted to test the model and a questionnaire was conducted to 150 firms that are operating in small and medium sized enterprises in Trabzon. The structural equation model was used to test the hypotheses. According to findings of the analysis it may be seen that an interdepartmental information system, compliance with an accounting information system, and an accounting information system activity have an effect on the institutionalisation level of enterprises.
AtıfScopus1OpenAlex1İncele - MakaleAçık Erişim2016Scopus SJRQ2Combustion Characteristics of Impregnated and Surface-treated Chestnut (Castanea sativa Mill.) Wood Left Outdoors for One Year
Fidan, Muhammed Said; Yaşar, Şekip Şadiye; Yaşar, Mehmet; Atar, Musa; Alkan, Elif
Treating wood with impregnating materials in order to improve resistance to burning is a commonly employed safety measure. In this study, chestnut (Castanea sativa Mill.) wood samples were impregnated using either Tanalith-E or Wolmanit-CB according to ASTM-D 1413-76 and surface-treated using water-based or synthetic varnish according to ASTM-D 3023. These samples were used to investigate the combustion characteristics of samples left outdoors for one year as detailed in ASTM-E 160-50. The combustion temperatures of the samples left outdoors were similar upon impregnation with either Tanalith-E or Wolmanit-CB. However, the combustion temperature of the samples treated with synthetic varnish was lower than those that were treated with water-based varnish. The time to collapse and the total duration of combustion of the samples left outdoors were shorter for those impregnated with Wolmanit-CB. Weight loss of the samples left outdoors was higher for those that were impregnated with Tanalith-E and treated with water-based varnish. Gas analysis of the samples that were left outdoors indicated that the O2 content of flue gas from samples that were impregnated with Wolmanit-CB and treated with synthetic varnish was high and the CO content of flue gas from the same samples was low.
AtıfScopus5WoS4OpenAlex8İncele - MakaleAçık Erişim2016Scopus SJRQ3Evaluation of the radioprotective effect of Turkish propolis on foreskin fibroblast cells
Yalcin, Can; Aliyazicioglu, Yuksel; Demir, Selim; Turan, Ibrahim; Bahat, Zumrut; Misir, Sema; Deger, Orhan
Aim of Study: Propolis is a resinous bee product, rich of polyphenolic compounds and flavonoids. It is known that in different geographic zones its chemical composition varies due to the different plant sources. Many biological properties including antimicrobial, antioxidative, anti-inflammatory, antitumoral, antigenotoxic, antimutagenic, cytostatic activities have been ascribed to propolis. These biological effects are predominantly attributed to its content of polyphenols. In this study, we aimed to evaluate the radioprotective effect of ethanolic extract of Turkish propolis. (EETP) against γ-ray-induced DNA damage on fibroblast cells using comet assay for the first time. Materials and Methods: Fibroblast cells were pretreated 15 and 30 min with concentrations of 100, 200 and 300 μg/mL EETP then they were exposed to 3 Gy γ-rays. Amifostine (synthetic aminothiol compound) was used as a positive control. Results: The results showed a significant decrease in γ-ray-induced DNA damage on cells treated with EETP and amifostine when compared to only irradiated cells. (P < 001). Conclusion: It was concluded that EETP prevent γ-ray-induced DNA damage in fibroblast cells and might have radioprotective activity.
AtıfScopus20WoS24OpenAlex25İncele - BildiriAçık Erişim2016A Study on the Performance of GPR for Detection of Different Types of Buried Objects
Toksoz, Derya; Yilmaz, Isik; Seren, Aysel; Mataraci, Isil; Salame, C.; Aillerie, M.; Papageorgas, P.
The objective of this research is to evaluate the applicability of Ground Penetrating Radar (GPR) method to detect burried objects in the shallow depths using 250 MHz and 800 MHz center frequency antennas. For this purpose, different objects were burried in several places of a certain test site. GPR data were collected along six paralel profiles using 250 MHz and 800 MHz antennas which are compatible with RAMAC CU II system. The reflections profile data were processed using the computer program ReflexW. After the processing of data, the reflected /scattered reflections on the processed radargrams were examined and the radargrams were interpreted to determine the depths and positions of the objects from the surface. Also, the data obtained from 250 and 800 MHz antennas were compared and the differences between them in terms of resolution were discussed.
AtıfScopus7WoS2OpenAlex4İncele - BildiriAçık Erişim2016The comparison of performance by using alternative refrigerant R152a in automobile climate system with different artificial neural network models
Kalkisim, A.T.; Hasiloglu, A.S.; Bilen, K.; Durak, R.; Tuzemen, S.
Due to the refrigerant gas R134a which is used in automobile air conditioning systems and has greater global warming impact will be phased out gradually, an alternative gas is being desired to be used without much change on existing air conditioning systems. It is aimed to obtain the easier solution for intermediate values on the performance by creating a Neural Network Model in case of using a fluid (R152a) in automobile air conditioning systems that has the thermodynamic properties close to each other and near-zero global warming impact. In this instance, a network structure giving the most accurate result has been established by identifying which model provides the best education with which network structure and makes the most accurate predictions in the light of the data obtained after five different ANN models was trained with three different network structures. During training of Artificial Neural Network, Quick Propagation, Quasi-Newton, Levenberg-Marquardt and Conjugate Gradient Descent Batch Back Propagation methodsincluding five inputs and one output were trained with various network structures. Over 1500 iterations have been evaluated and the most appropriate model was identified by determining minimum error rates. The accuracy of the determined ANN model was revealed by comparing with estimates made by the Multi-Regression method.
AtıfScopus1OpenAlex2İncele - MakaleAçık Erişim2016Scopus SJRQ2Kinetic and in silico studies of hydroxy-based inhibitors of carbonic anhydrase isoforms I and II
Ekhteiari Salmas, Ramin; Mestanoglu, Mert; Durdagi, Serdar; Sentürk, Murat; Kaya, A. Afşin; Kaya, Elif Çelenk
A series of hydroxy and phenolic compounds have been assayed for the inhibition of two physiologically relevant carbonic anhydrase (CA, EC 4.2.1.1) isozymes, the cytosolic human isozymes I and II. The investigated molecules showed inhibition constants in the range of 1.07-4003 and 0.09-31.5 μM at the hCA I and hCA II enzymes, respectively. In order to investigate the binding mechanisms of these inhibitors, in silico studies were also applied. Molecular docking scores of the studied compounds are compared using three different scoring algorithms, namely Glide/SP, Glide/XP and Glide/IFD. In addition, different ADME (absorption, distribution, metabolism and excretion) analysis was performed. All the examined compounds were found within the acceptable range of pharmacokinetic profiles.
AtıfScopus10WoS11OpenAlex15İncele - MakaleAçık Erişim2016Scopus SJRQ2Kinetic characterization of GES-22 β-lactamase harboring the M169L clinical mutation
Saral, Aysegul; Leonard, David A; Duzgun, Azer Ozad; Cicek, Aysegul Copur; June, Cynthia M; Sandalli, Cemal
The class A β-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a structure that is known to have major effects on substrate selectivity in class A β-lactamases, we expressed, purified and kinetically characterized this novel variant. Our results show that compared with GES-116×His, GES-226×His displays more efficient hydrolysis of penicillins, and aztreonam, but a loss of efficiency against ceftazidime. In addition, the M169L substitution confers on GES-22 more efficient hydrolysis of the mechanistic inhibitors clavulanic acid and sulbactam. These effects are highly similar to other mutations at the homologous position in other class A β-lactamases, suggesting that this methionine has a key structural role in aligning active site residues and in substrate selectivity across the class.
AtıfScopus5WoS4OpenAlex5İncele - MakaleAçık Erişim2016Scopus SJRQ2Determining the Effect of Seasonal Variation in Spruce (Picea orientalis L.) Wood Treated with Various Impregnations on Combustion Resistance
Yasar, Ş. Şadiye; Fidan, M. Said; Yaşar, Mehmet; Atar, Musa; Alkan, Elif
Prepared test specimens were surface treated and coated with synthetic and water-based outdoor varnishes after being chemically impregnated. The test specimens were left outdoors to determine the effects of impregnation and treatment on the wood during each of the four seasons. Caucasian spruce (Picea orientalis L.) test specimens were prepared and combustion analyses were performed. As a result of the combustion test, weight loss results, as compared with the control, were 89% lower in the spring specimens, 90% lower with impregnation, and 90% lower with the synthetic varnish coating. Furthermore, the O2 amount during combustion was found to be the highest in combustion with a flame source in the winter specimens (21%). The CO2 amount was the highest in combustion without a flame source for full-year specimens (20%). The CO amount was the highest in combustion without a flame source of full-year specimens (31,787 ppm), and the NO amount was the highest during glowing of full-year specimens (55 ppm). Final results showed impregnation with Tanalith-E and water-based varnish coating to be the most effective fire protective treatments.
AtıfScopus5WoS5OpenAlex3İncele - MakaleAçık Erişim2016Scopus SJRQ3Investigation of structural and tribological properties of duplex surface treated pure titanium
Çelik, I.; Karakan, M.
Commercial pure titanium (CP-Ti) is used in many engineering fields because of its superior properties such as excellent corrosion resistance, high strength/weight ratio, and biocompatibility. However, it is not available at the desired rate, since the CP-Ti has poor wear resistance. For this reason, many surface treatments have been applied to improve the poor tribological properties of the CP-Ti. In this study, duplex surface treatments, which are the combination of treatments of electroless Ni-B coating and plasma nitriding, were applied on the surfaces of the CP-Ti. Structural properties of the different surfaces of the treated materials were investigated using scanning electron microscopy (SEM) and X-ray diffraction (XRD). Microhardness measurements were made for the determination of mechanical properties and the pin-on-disk wear tests were made to determine the tribological properties. It was observed that poor wear resistance of the CP-Ti was improved with duplex surface treatments. The results showed that surface hardness, friction coefficient, and surface roughness of coated samples were better than of uncoated CP-Ti.
AtıfScopus7WoS5OpenAlex6İncele - MakaleAçık Erişim2016Scopus SJRQ3Determination of stand structure in even-aged oriental beech forests in Turkey; [Determinación de la estructura de rodales de Fagus orientalis coetáneos en Turquía]
Kahriman, Aydın; Altun, Lokman; Güvendi, Engin
This study aimed at developing a stand yield model for even-aged and pure Oriental beech (Fagus orientalis) stands in Sinop Province, located in the north of Turkey. The data used in this study were obtained from 238 sample plots. The sample plots are 24–131 years of stand age range, 19.0–35.9 m of site index range, and 2.2–10.8 of stand density range (relative density index). With the generated equation systems, stand age, site index and density of the three main factors in Oriental beech stands, including the effects of individual, dual and triple factor interactions on the stands were numerically determined. As for even-aged Oriental beech stands, the main stand volume values increase depending on age, site index and density. The number of stems per hectare decreases as the stand grows older, and site index rises; the number, however, increases in parallel with stand density. The current annual volume increment reaches a peak at 30-35 years at all site index groups and density levels, and begins to fall afterwards. Mean annual volume increment peaks up at 65-75 years at all site index classes and density levels, before beginning to decline. The results were in arrangement with the acknowledged growth rules. Stand yield models were assessed as Density-Variable Yield Table used for estimation of the remaining, removal and total stands.
AtıfScopus4WoS3OpenAlex1İncele - MakaleAçık Erişim2016Scopus SJRQ2Diversity and ecology of benthic algae in Karagöl Lake, Karagöl-Sahara National Park (Şavşat, Artvin, Turkey)
Akar, Bülent; Şahın, Bülent
Benthic algal flora of Karagöl Lake, its seasonal variation, and the physical and chemical parameters of the water were studied between October 2008 and September 2010. The algal flora consisted of 112 taxa belonging to the divisions Charophyta (41), Chlorophyta (33), Cyanobacteria (18), Euglenozoa (17), Miozoa (2), and Ochrophyta (1). Six desmid taxa found in this research are new records for the freshwater algal flora of Turkey. The qualitative dominance of benthic taxa typical of slightly alkaline and mesotrophic ecosystems was observed. The qualitative and seasonal variations in epipelic taxa analyzed were dependent on the physicochemical characteristics of the water. Water quality was analyzed on the basis of benthic taxa, which are bioindicators. The physicochemical properties of the water are suitable for the development of a rich algal flora (especially desmids). According to the benthic algal composition and indicator species, it is estimated that Karagöl Lake has mesotrophic lake characteristics. This is the first study of benthic algal flora of Karagöl Lake and marks a significant contribution to the knowledge of Karagöl-Sahara National Park’s aquatic biodiversity.
AtıfScopus5WoS3OpenAlex3TR Dizin1
İncele - MakaleAçık Erişim2016Scopus SJRQ3Existence and uniqueness theorems for sequential linear conformable fractional differential equations
Gökdoğan, Ahmet; Ünal, Emrah; Çelik, Ercan
Recently, a new definition of fractional derivative called as the conformable fractional derivative which based on limits introduced by Khalil et al (2014). Later, Abdeljawad (2015) improved these definitions and gave the basic concepts in this new fractional calculus. In this paper, we generalize Abel's formula and Wronskian determinant definition and establish existence and uniqueness theorems for sequential linear conformable fractional differential equations.
AtıfScopus27WoS26OpenAlex40İncele - MakaleAçık Erişim2016Scopus SJRQ2Effect of Turkish pollen and propolis extracts on caspase-3 activity in myeloid cancer cell lines
Uçar, Meltem; Değer, Orhan; Gerigelmez, Asuman Yiğit; Cengiz, Sevil; Barlak, Yaşam; Ovalı, Ercüment
Purpose: To investigate the apoptosis-inducing capacity of dimethyl sulfoxide (DMSO) extracts of bee pollen and propolis in HL-60 Myeloid Cancer Cell Lines. Methods: DMSO extracts of pollen and propolis were incubated separately with HL-60 cells, and caspase-3 activity evaluated. In order to determine the cell cycle characteristics of HL-60 cells with and without extracts of pollen and propolis, the cells were analysed using flow cytometry. Results: The DMSO extract of propolis (0.5 mg/mL) increased apoptosis from undetectable levels to 60.1%, while maintaining cell viability. The DMSO extract of pollen (2 mg/ml) increased apoptosis from undetectable levels to 52.2% while decreasing cell viability by 62%. Caspase-3 activity in HL-60 cells incubated with DMSO extracts of pollen and propolis were 3.6-to 12-fold higher than in controls. Conclusion: Turkish pollen and propolis individually increase apoptosis and the activity of caspase-3 in HL-60 cells. This finding indicates that bee products may have beneficial effects in the treatment of cancer.
AtıfScopus12WoS10OpenAlex12İncele