Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(77)
- Merdan, Mehmet(73)
- Duran, Celal(54)
- Ozdes, Duygu(50)
- Baltaci, Cemalettin(45)
- Kaygusuz, Abdullah(45)
- Kulakaç, Nurşen(39)
- Ashyralyyev, Charyyar(38)
- Karsli, Orhan(37)
- Demir, Selim(36)
- Öztürk, Serkan(36)
- Dokuz, Abdurrahman(35)
- Turan, Ibrahim(35)
- Araz, Onur(33)
- Kandemir, Raif(31)
- Sipahi, Ferkan(30)
- Topal, Fevzi(30)
- Kurt, Kemal(28)
- Peker, Iskender(28)
- Arslan, Mehmet(27)
- Baltacı, Cemalettin(27)
- Maden, Nafiz(27)
- Ozturk, Samet(27)
- Aydin, Aydanur(26)
- Vural, Alaaddin(26)
- Bayrakdaroglu, Serdar(25)
- Kurnaz, Muammer(25)
- Reis, Hatice Catal(25)
- Akar, Zeynep(24)
- Aydin, Faruk(24)
- Gücer, Mehmet Ali(24)
- Topal, Meryem(24)
- Yolcu, Halil(24)
- Yücel, Cem(24)
- Anaç, Halil(23)
- Kankal, Murat(23)
- Ürkek, Bayram(23)
- Aliyazicioglu, Yuksel(22)
- Günen, Mehmet Akif(22)
- Tuncer, Metin(22)
Yayınlar
- MakaleAçık Erişim2013Scopus SJRQ4Sequence Variant in the LPIN1 gene in Patients with Metabolic Syndrome
Kural, Birgul Vanizor; Deger, Orhan; Erem, Cihangir; Yücesan, Fulya Balaban; Barlak, Yasam; Turan, Ibrahim; Aliyazicioglu, Rezzan
Objective: Metabolic syndrome (MetS) is a complex disease characterized by insulin resistance, abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia and low HDL-cholesterol level. The aim of the study was to evaluate the sequence variations in the LPIN1 gene in MetS. This gene codes lipin-1 protein which functions as Mg-dependent phosphatidic phosphatase enzyme and transcriptional coactivator. Material and Methods: The study groups included 73 MetS (19 M/54 F) and 56 non-MetS (16 M/40 F). Sequence variation in exons 2, 4, 5 and 14 of the LPIN1 gene were investigated by DNA sequencing method. Results: c.696 G>C variant (p.S232S) in exon 5 was observed in only one women with MetS. But this variation is not important because of coding same amino acid. Conclusion: Any important sequence variant was not detected in exons 2, 4, 5 and 14 in the LPIN1 gene in MetS.
AtıfWoS2OpenAlex2TR Dizin1
İncele - BildiriAçık Erişim2013Scopus SJRQ1The Pharmacoeconomic Efficacy of Ivabradine and Nebivolol Treatment of Stable Angina Pectoris in Patients with Left Ventricular Dysfunction
Kutlu, Rasim; Memetoglu, Mehmet Erdem
- MakaleAçık Erişim2013Evaluation of cardiovascular risk factors among university students in Turkey: a cross-sectional survey
Kutlu, Rasim; Memetoglu, Mehmet Erdem
Background - Recent data indicate increasing rates of mortality from cardiovascular (CV) disease in Turkey. This study aimed to evaluate CV disease risk factors among university students in Northern Turkey. Methods - In this cross sectional descriptive study, 302 students were randomly recruited (171 females (57%) and 131 males (43%), mean age of 20 +/- 2.1 years). Blood glucose, cholesterol profile (total, high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterols), triglyceride, glycosylated haemoglobin, resting blood pressure, and body mass index were measured using standard protocols. All participants were asked to complete a questionnaire including questions on lifestyle, genetic predisposition, smoking habit, and psychosocial factors. Results - The mean systolic and diastolic blood pressure of students were 127.1 +/- 13.5 mmHg and 78.3 +/- 12.4 mmHg. The mean values were 98.4 +/- 14.2 mg/dL for fasting blood glucose value, 5.4 +/- 0.4 for HbA(1c), 80.0 +/- 10.3 beats/min for heart rate, for total cholesterol 199.1 +/- 24.6 mg/dL, 43.8 +/- 9.9 mg/dL for HDL, 114.7 +/- 24.1 mg/dL for LDL, 199.1 +/- 24.6 mg/dL for trygliceride, 24.8 +/- 3.6 kg/m(2) for body mass index, 97.6 +/- 17.9 cm for waist circumference. No significant difference was observed between gender according to CV risk factors' values statistically. It was observed that 111 (36.8%) students were overweight, 32 (10.6%) were obes. About 135 (44.0%) of students had abnormally unacceptable WC value. Smoking habit was seen in 130 (43.0%) students [73 (24.2%) male and 57 (18.9%) female]. Conclusion - A substantial proportion of Turkish students were overweight or obese, and had smoking habit. Our results underscore the need to implement health promotion programmes and perform large-scale epidemiological studies within the general Turkish young adult population.
AtıfWoS5OpenAlex12İncele - BildiriAçık Erişim2013Scopus SJRQ1Evaluation of Cardiovascular Risk Factors Among University Students in Northern Turkey: A Cross-sectional Survey
Kutlu, Rasim; Memetoglu, Mehmet Erdem
AtıfWoS1OpenAlex1İncele - MakaleYalnız künye2013Scopus SJRQ2Coronary Flow Reserve and Myocardial Performance Index in Newly Diagnosed Diabetic Patients
Kalkan, Gulhan Yuksel; Gür, Mustafa; Sahin, Durmus Yildiray; Baykan, Ahmet Oytun; Elbasan, Zafer; Kuloglu, Osman; Kivrak, Ali; Türkoglu, Caner; Arik, Osman Ziya; Çayli, Murat
BackgroundPatients with diabetes mellitus (DM) are at high risk of left ventricular (LV) dysfunction. A reduction of coronary flow reserve (CFR) has been demonstrated in diabetic patients without coronary artery stenosis. In this study, we investigated the association between LV myocardial diastolic and systolic functions and the CFR in newly diagnosed diabetic patients in the absence of coronary artery disease. MethodWe studied 88 patients (mean age 4910years) with newly diagnosed DM and 40 healthy control subjects (mean age 509years). All subjects underwent transthoracic echocardiography. The myocardial performance index (MPI) was determined by using pulsed-wave Doppler. The CFR was calculated as the hyperemic to resting coronary diastolic peak velocities ratio. ResultsPatients with diabetes had significantly longer mitral E-wave deceleration time and higher MPI value than control group (P=0.023 and P<0.001, respectively). The mean CFR was lower in diabetic patients compared with controls (P=0.001). The MPI was significantly correlated with CFR (r=-0.371, P<0.001), LV ejection fraction (r=-0.274, P=0.018) E/A ratio (r=-0.244, P=0.024), and glycosylated hemoglobin (HbA1c) (r=0.476, P<0.001). Multivariate regression analysis showed that MPI was independently associated with CFR (=-0.292, P<0.0001) and HbA1c level (=0.372, P<0.0001). ConclusionsThe MPI was independently associated with CFR in newly diagnosed diabetic patients. The decrease in CFR may cause LV systolic and diastolic dysfunction in asymptomatic diabetic patients.
AtıfWoS11OpenAlex10
İncele - BildiriYalnız künye2013Scopus SJRQ1THE ROLE OF OXIDATIVE STRESS IN CHILDREN WITH ACUTE AND CHRONIC IDIOPATHIC THROMBOCYTOPENIC PURPURA
Erduran, E.; Cakmak, S.; Aliyazicioglu, Y.; Turan, I.
- MakaleAçık Erişim2013Scopus SJRQ3Comparison of the safety and efficacy of ivabradine and nebivolol mono- and combination therapies in the treatment of stable angina pectoris patients with left ventricular dysfunction
Kutlu, Rasim; Memetoglu, Mehmet Erdem; Muratalievic, Tolkun Murataliev
We aimed to investigate the pharmacoeconomic efficacy of ivabradine and nebivolol in treatment of stable angina pectoris patients with left ventricular dysfunction prospectively. Pharmacoeconomic analysis was performed by using cost minimization analysis, and cost effectiveness analysis. After 6 months' treatment LVEF for the nebivolol group (17 patients, 50%) improved by (38 +/- 6.5) to (41 +/- 3.2), (p>0.05) and for the ivabradine group (17 patients, 50%) (37 +/- 5.4) to (41 +/- 2.3), (p>0.05), mean MET value in the nebivolol group increased from (3.7 +/- 1.2) to (5.5 +/- 1.6), (p>0.05), versus from (3.6 +/- 1.5) to (5.5 +/- 1.4), (p>0.05) in the ivabradine group, cost minimization analysis results showed a difference in the total cost of treatment was US$ 5288.7 in favor of nebivolol. The findings suggest that nebivolol is more cost-effective than ivabradine in the treatment of patients with left ventricular dysfunction.
AtıfWoS2OpenAlex2İncele - BildiriYalnız künye2013Scopus SJRQ1Automated Functional Imaging in Atrioventricular Delay Time Optimization in Patients with Dual Chamber Pacemakers
Arik, Osman Ziya; Kalkan, Gulhan Yuksel; Sahin, Durmus Yildiray; Elbasan, Zafer; Gür, Mustafa; Kuloglu, Osman; Tekin, Kamuran; Gençaslan, Murat; Türkoglu, Caner; Uçak, Haci Ali
- MakaleYalnız künye2013Scopus SJRQ3COMPARATIVE INVESTIGATION THE USE OF METHANOL AND METHYL TERTIARY BUTYL ETHER IN GASOLINE ON ENGINE PERFORMANCE, CO EMISSIONS AND FUEL COST
Sezer, Ismet; Bilgin, Atilla
This study is concerned with investigating experimentally the effects of methanol and Methyl tert-Butyl Ether (MTBE) blending to base gasoline on the performance CO emissions and fuel cost of a spark ignition (SI) engine. The fuel blends were prepared by addition 5, 10, 15, and 20 vol % of methanol and MTBE with a specified amount of base gasoline. The methanol- and MTBE-gasoline blends were designated as M5, M10, M15, M20, and MTBE5, MTBE10, MTBE15, MTBE20, respectively. Experiments were conducted under various engine speeds, spark timings (STs), and compression ratios (CRs). The engine was operated under wide-open throttle conditions. The results of the study showed that the M5 and MTBE10 blends yield the best engine performance in terms of the brake mean effective pressure (bmep), while the M20 and MTBE15 blends are the best performers in terms of brake thermal efficiency (bte). Moreover, M20 and MTBE10 blends give the minimum CO emission values. The economical analysis performed in the study is based on both the current blending fuel prices in Turkey and brake specific fuel consumption (bsfc) of the engine while using gasoline, methanol-gasoline, and MTBE-gasoline blends. It was obtained that, in contrast to the improvement of engine performance, efficiency and CO emissions, methanol and MTBE blends caused increases in fuel costs because of the expensive methanol and MTBE prices in Turkey. Uncertainty analysis was also performed in this study, and it was found that; the uncertainties in the measurement devices do not have noticeable influences on the variations of engine characteristics.
AtıfWoS3İncele - MakaleAçık Erişim2013Scopus SJRQ1Numerical solution of the fractional-order Vallis systems using multi-step differential transformation method
Merdan, Mehmet
In this paper, we examine a fractional order Vallis systems. We also fulfil a detailed analysis on the stability of equilibrium. Multi-step differential transform method (MsDTM) extends to give approximate and analytical solutions of a fractional order Vallis systems. Numerical simulations are submitted to verify the validity and reliability results obtained from these methods.
AtıfScopus10WoS10OpenAlex9
İncele - MakaleYalnız künye2013Adaptive multi-step differential transformation method to solve ODE systems
Gökdoǧan, Ahmet; Merdan, Mehmet
In this paper, it is given a fast algorithm to solve chaotic differential systems using the multi-step differential transforms method (MsDTM). The approach is applied to a number of chaotic nonlinear differential equations and numerical results are given. Performance analyses reveal that the proposed approach is an efficiency tool to solve using fewer time step to the considered equation systems.
AtıfScopus6WoS4İncele - MakaleYalnız künye2013Scopus SJRQ1Evaluation of the effect of earthquake frequency content on seismic behavior of cantilever retaining wall including soil-structure interaction
Cakir, Tufan
A three-dimensional backfill-structure-soil/foundation interaction phenomenon is simulated using the finite element method in order to analyze the dynamic behavior of cantilever retaining wall subjected to different ground motions. Effects of both earthquake frequency content and soil-structure interaction are evaluated by using five different seismic motions and six different soil types. The study mainly consists of three parts. In the first part, following a brief review of the problem, the finite element model with viscous boundary is proposed under fixed-base condition. In the second part, analytical formulations are presented by using modal analysis technique to provide the finite element model verification, and reasonable agreement is found between numerical and analytical results. Finally, the method is extended to further investigate parametrically the effects of not only earthquake frequency content but also soil/foundation interaction, and nonlinear time history analyzes are carried out. By means of changing the soil properties, some comparisons are made on lateral displacements and stress responses under different ground motions. It is concluded that the dynamic response of the cantilever wall is highly sensitive to frequency characteristics of the earthquake record and soil-structure interaction.
AtıfScopus111WoS90OpenAlex114İncele - MakaleAçık Erişim2013Scopus SJRQ2The effect of prenatal exposure to 900-MHz electromagnetic field on the 21-old-day rat testicle
Hanci, Hatice; Odaci, Ersan; Kaya, Haydar; Aliyazicioǧlu, Yüksel; Turan, Ibrahim; Demir, Selim; Çolakoǧlu, Serdar
The aim of this study was to investigate the effect of exposure to a 900-MHz electromagnetic field (EMF) in the prenatal term on the 21-old-day rat testicle. Pregnant rats were divided into control (CG) and EMF (EMFG) groups. EMFG was exposed to 900-MHz EMF during days 13-21 of pregnancy. Newborn CG rats were obtained from the CG and newborn EMFG (NEMFG) rats from the EMFG. Testicles were extracted at postnatal day 21. Lipid peroxidation and DNA oxidation levels, apoptotic index and histopathological damage scores were compared. NEMFG rats exhibited irregularities in seminiferous tubule basal membrane and epithelium, immature germ cells in the lumen, and a decreased diameter in seminiferous tubules and thickness of epithelium. Apoptotic index, lipid peroxidation and DNA oxidation were higher in NEMFG rats than in NCG. 21-day-old rat testicles exposed to 900-MHz EMF in the prenatal term may be adversely affected, and this effect persists after birth.
AtıfScopus65WoS60OpenAlex64İncele - MakaleYalnız künye2013Scopus SJRQ1The effect of composite patches on the failure of adhesively-bonded joints under bending moment
Akpinar, Salih
In this study, it was aimed to compare mechanical behavior of double-strap joints with aluminum (AA2024-T3) or 16-ply laminate of carbon/epoxy composite (T300/934) patches of different orientation angles at their overlap area subjected to bending moment. For this purpose, AA2024-T3 aluminum was used as adherend, while the adhesive was a two-part paste (DP 460). Six different types of joint samples were subjected to bending moment. The effect of patch material on failure load and stress distribution was examined experimentally and numerically. In the numerical analysis, the composite patches were assumed to behave linearly elastic, while adherend and adhesive layers were assumed to be nonlinear. It was found that the data obtained from 3-D finite element analysis were coherent with experimental results. Meanwhile, experiments showed that fiber orientation angles of the patches markedly affected the failure load of joints, failure mode and stress distributions appeared in adhesive and composite.
AtıfScopus38WoS38OpenAlex38İncele - MakaleYalnız künye2013Scopus SJRQ2Radical scavenging and antioxidant capacity of serotonin
Sarikaya, S. Beyza Öztürk; Gülçin, Ilhami
Serotonin is a monoamine neurotransmitter and biochemically derived from tryptophan. The present paper examines the in vitro antioxidant and radical scavenging capacity of serotonin using different in vitro methodologies. For the determination of antioxidant activity of serotonin, 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH) scavenging, 2,2́-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging activity, total antioxidant activity determination by ferric thiocyanate, total reducing ability determination by Fe3+-Fe2+ transformation method, superoxide anion radical scavenging by riboflavin-methionine-illuminate system, H2O2 scavenging and ferrous ions (Fe +) chelating activities of serotonin were performed. Also, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), α-tocopherol and trolox, a water-soluble analog of α-tocopherol, were used as the reference antioxidant radical scavenger compounds. Serotonin completely inhibited lipid peroxidation of a linoleic acid emulsion at 15 μg/mL concentration. On the other hand, the above mentioned standard antioxidants displayed inhibition of 92.2, 99.6, 84.6 and 95.6% on peroxidation of linoleic acid emulsion, respectively at the 45 μg/mL concentration. In addition, serotonin was effective in DPPH· scavenging, ABTS•+ radical scavenging, superoxide anion radical scavenging, H2O2 scavenging, ferric ions (Fe3+) reducing power and metal chelating on ferrous ions (Fe+) activities. Also, those various antioxidant activities were compared to BHA, BHT α-tocopherol and trolox as references antioxidant compounds.
AtıfScopus31OpenAlex32İncele - MakaleAçık Erişim2013Scopus SJRQ3Solid phase extraction of Cd(ii) and pb(ii) ions by a new carbothioamide derivative
Ozdes, Duygu; Duran, Celal; Bayrak, Hacer; Serencam, Huseyin; Basri Senturk, Hasan
An effective, simple, low cost and accurate sorption-spectrophotometric platform for the extractions and subsequent quantifications of Cd(II) and Pb(II) ions in food and environmental samples has been described in this dissertation. The separation and preconcentration of the analyte ions were accomplished by solid phase extraction method based on the adsorption of their N-(4-methylphenyl)-2-{[(4-phenyl-5-pyridin-4-yl-4H-1,2,4-triazol-3-yl)thio] acetyl} hydrazinecarbothioamide (MFPTAHK) complex on Amberlite XAD-8 resin in a mini column. The developed method was systematically investigated in different set of experimental parameters that influence the separation and preconcentration of Cd(II) and Pb(II) ions. The precision of the method was determined by reproducibility studies and expressed as relative standard deviations (RSD %) which were less than 4% for both analyte ions. The limits of detections (LODs) for Cd(II) and Pb(II) ions based on the three times the standard deviation of the blanks (N:10) were found to be 0. 31 ?g L-1 and 0. 86 ?g L-1, respectively. The developed SPE procedure was utilized for the simultaneous extraction and determinations of Cd(II) and Pb(II) ions levels in rice, cracked wheat and red lentil as food samples and various water samples.
AtıfScopus5WoS4OpenAlex5İncele - MakaleYalnız künye2013Scopus SJRQ1Effects of laminate carbon/epoxy composite patches on the strength of double-strap adhesive joints: Experimental and numerical analysis
Akpinar, Salih
In this study, mechanical properties of double-strap joints with aluminum or composite patches of different orientation angles at their overlap area were investigated under tensile loading. For this purpose, AA2024-T3 aluminum was used as adherend, while patches were either AA2024-T3 aluminum or 16-ply laminate of carbon/epoxy composite with five different orientation angles ([0]16, [90]16, [0/90]8, [45/-45]8, [0/45/-45/90]4). A two-part paste adhesive (DP 460) was used to bond adherend and patches. Six different types of joint samples were subjected to tensile loading. The effect of patch material on failure load and stress distribution was examined experimentally and numerically. As a result, it was concluded that the data obtained from 3-D finite element analysis were coherent with experimental results and additional to that fiber orientation angles of the patches markedly affected the failure load of joints, failure mode and stress distributions appeared in adhesive and composite.
AtıfScopus53WoS47OpenAlex52İncele - MakaleYalnız künye2013Scopus SJRQ1Single-Laboratory Validation for the Determination of Aflatoxin B1, B2, G1, and G2 in Foods Based on Immunoaffinity Column and Liquid Chromatography with Postcolumn Derivatization and Fluorescence Detection
Baltacı, Cemalettin; İlyasoğlu, Huri; Yüksel, Ferhat
This study presents a method validation procedure for the determination of aflatoxin B1, B2, G1, and G2 in hazelnut, hazelnut paste, walnut, peanut, pistachio, corn, and wheat. The method consisting of clean-up with immunoaffinity column, high performance liquid chromatography with postcolumn derivatization and fluorescence detection was validated in accordance with Commission Regulation 2004/882/EC. The selectivity, linearity, decision limit, detection capability, detection and quantification limits, precision, recovery, ruggedness, and measurement uncertainty of the method were determined. The limit of detection and limit of quantification values (μg/kg) were: aflatoxin B1, 0. 02, 0. 07; aflatoxin B2, 0. 01, 0. 02; aflatoxin G1, 0. 02, 0. 07; and aflatoxin G2, 0. 01, 0. 03. The relative standard deviation values for the repeatability and within-laboratory reproducibility were below 4 and 5 %, respectively. The recovery values of the spiked samples ranged from 80 to 105 %. These results complied with minimum performance criteria established by regulation 2006/401/EC. Therefore, the procedure can be implemented for the routine analysis of aflatoxins in the studied matrices.
AtıfScopus12WoS11OpenAlex15İncele - MakaleYalnız künye2013Scopus SJRQ4A new record of the genus paranemastoma redikorzev, 1936 (Opiliones: Nemastomatidae) from Turkey
Kurt, Kemal; Erman, Ömer Köksal; Snegovaya, Nataly Yu.
Paranemastoma kalischevskyi (Roewer, 1951) is recorded in Turkey for the first time. The morphological characteristic features, exact locality and general distribution are provided for this species.
AtıfScopus2WoS3OpenAlex2İncele - MakaleAçık Erişim2013Scopus SJRQ1On numerical solution to fractional non-linear oscillatory equations
Merdan, Mehmet; Gökdoǧan, Ahmet; Yildirim, Ahmet
In this article, the multi-step differential transform method (MsDTM) is applied to give approximate solutions of nonlinear ordinary differential equation such as fractional-non-linear oscillatory and vibration equations. The results indicate that the method is very effective and sufficient for solving non-linear differential equations of fractional order.
AtıfScopus14WoS11OpenAlex11İncele