Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Uzun, Sevda(67)
- Merdan, Mehmet(59)
- Duran, Celal(49)
- Ozdes, Duygu(46)
- Kaygusuz, Abdullah(45)
- Demir, Selim(37)
- Turan, Ibrahim(37)
- Karsli, Orhan(36)
- Öztürk, Serkan(35)
- Dokuz, Abdurrahman(34)
- Araz, Onur(32)
- Kandemir, Raif(31)
- Kulakaç, Nurşen(29)
- Sipahi, Ferkan(29)
- Arslan, Mehmet(27)
- Baltaci, Cemalettin(27)
- Baltacı, Cemalettin(27)
- Kurt, Kemal(27)
- Topal, Fevzi(27)
- Gücer, Mehmet Ali(25)
- Peker, Iskender(25)
- Aydin, Faruk(24)
- Bayrakdaroglu, Serdar(24)
- Maden, Nafiz(24)
- Ozturk, Samet(24)
- Vural, Alaaddin(24)
- Yolcu, Halil(24)
- Yücel, Cem(24)
- Aliyazicioglu, Yuksel(23)
- Kankal, Murat(23)
- Reis, Hatice Catal(23)
- Ürkek, Bayram(23)
- Günen, Mehmet Akif(22)
- Kurnaz, Muammer(22)
- Topal, Meryem(22)
- Karimullah, Suud Sarim(21)
- Uysal, Ibrahim(21)
- Ashyralyyev, Charyyar(20)
- Aydin, Aydanur(20)
- Bayraktar, Alemdar(20)
Yayınlar
- MakaleAçık Erişim2016Scopus SJRQ3Physicochemical and bioactive properties of cakes incorporated with gilaburu fruit (Viburnum opulus) pomace
Şeker, I.T.; Ertop, M.H.; Hayta, M.
In this study the valorisation of a gilaburu (Viburnum opulus) fruit pomace, a waste product remaining after juice extraction, was investigated. The pomace was incorporated into cake formulation at the level of 0, 5, 10 and 15%, based on wheat flour weight. Results indicated that the batter viscosity increased and pH decreased by the increasing of the concentration of pomace level in cake formulation. Depending on incorporation level, reduction on the volume and height of the cake samples were observed. The hardness values increased whereas the chewiness and gumminess values of the cake samples decreased with an increasing of pomace incorporation level. Gilaburu pomace addition caused significant (P<0.05) changes on L*, a*, and b* values of crumb, whereas no significant differences have been determined on the L* and b* values of crust of the samples. In sensory analyses, 5% gilaburu pomace added cake sample had the highest overall acceptability score. The total phenolic content and radical-scavenging activity values of cake samples increased proportionally with the level of pomace incorporation. According to the study, evaluation of gilaburu pomace waste as ingredient in developing alternative functional and/or value-added products by the food industry could be suggested.
AtıfScopus13WoS12OpenAlex16
İncele - MakaleYalnız künye2016Scopus SJRQ3Selective cytotoxic effect of Rhododendron luteum extract on human colon and liver cancer cells
Demir, Selim; Turan, Ibrahim; Aliyazicioglu, Yuksel
Purpose: The genus Rhododendron is distributed entirely in the world with the exception of South and Central America and Africa, growing in a large diversity of climatic conditions. This genus is a rich source of phenolic compounds, especially flavonoids, essential oils, chromones, terpenoids, and steroids. It has many biological properties such as antioxidant, anti-inflammatory, antiviral, antibacterial, anticancer, antidiabetic, immunomodulatory, cardioprotective and hepatoprotective among others due to their polyphenolic constituents. The objective of the current study was to evaluate the antioxidant properties and cytotoxic activity of dimethyl sulfoxide extract of flowers of Rhododendron luteum (DEFR) for the first time. Methods: The total polyphenolic contents (TPC), total flavonoid contents (TFC) and ferric reducing antioxidant power (FRAP) of the extract were evaluated using spectrophotometry procedures. The cytotoxic activity of the extract on three cancers (human breast, colon and liver carcinoma) and human foreskin fibroblast cells was determined using the MTT assay. Results: TPC and FRAP values were found 54.2+.0.38 mg gallic acid equivalents and 164.2±1.77 mg trolox equivalents per to g sample, respectively. R. luteum extract exhibited selective cytotoxicity against colon and liver cancer cells compared to normal fibroblast cells, while this selective cytotoxicity was not observed in breast cancer cells. Conclusion: Our results demonstrate that the Rhododendron luteum may be a great source of antioxidant and antitumor natural agents due to their capability of decreasing cancer cells proliferation.
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İncele - MakaleAçık Erişim2016Scopus SJRQ3Role of oxidative stress in the pathophysiology of Toxoplasma gondii infection
Dincel, Gungor Cagdas; Atmaca, Hasan Tarik
Oxidative stress (OS) plays an essential role in the pathogenesis of common neurodegenerative diseases. We have previously shown that Toxoplasma gondii (T. gondii) induces high nitric oxide (NO) production, glial activation, and apoptosis that altogether cause severe neuropathology in toxoplasma encephalitis (TE). The objective of this study was to investigate the cytotoxic effect of OS and to identify a correlation between the causes of T. gondii induced neuropathology. Expression levels of glutathione reductase (GR), Cu/Zn superoxide dismutase (SOD1), neuron specific enolase (NSE), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated. Results of the study revealed that the levels of GR (P <0.005) and NSE (P <0.001) expression in the brain tissue markedly increased while SOD1 activity decreased (P <0.001) in the infected group compared to the non-infected group. In addition, intense staining for 8-OHdG (P <0.05) was observed both in the nucleus and the cytoplasm of neurons and glial cells that underwent OS. These results were reasonable to suggest that T. gondii-mediated OS might play a pivotal role and a different type of role in the mechanism of neurodegeneration/neuropathology in the process of TE. The results also clearly indicated that increased levels of NO and apoptosis might contribute to OS-related pathogenesis of TE. As a result, OS and expression of NSE might give an idea of the disease progress and may have a critical diagnostic significance for patients with T. gondii infection.
AtıfScopus64WoS55OpenAlex62İncele - MakaleYalnız künye2016Scopus SJRQ1Systemic oxidant/antioxidant balance in human abdominal aortic aneurysm
Menteşe, Umit; Turan, Ibrahim; Usta, Sefer; Demir, Selim; Koral, Özgür; Öztaş Menteşe, Seda; Çavuşoǧlu, Ismail Gökhan; Karahan, Süleyman Caner; Alver, Ahmet; Doǧan, Orhan Veli
The aim of this study was to evaluate the oxidant-antioxidant balance in patients with abdominal aortic aneurysms (AAA). Forty-two consecutive patients with AAA and 46 control subjects were included. Total oxidant status (TOS) and total antioxidant status (TAS) levels were measured and the oxidative stress index (OSI) value determined. Serum TOS and OSI values in patients with AAA were higher than those in the controls (p<0.001, p<0.001, respectively). There was a positive correlation between abdominal aortic diameters, serum TOS levels (r=0.592, p<0.001) and OSI values (r=0.598, p<0.001). A cut-off value of 17.68 μmol H2O2 equivalent/L for TOS was associated with 86% sensitivity and 83% specificity and a cut-off value of 1.77 for OSI was associated with 86% sensitivity and 81% specificity for predicting AAA. Systemic oxidative imbalance develops in patients with AAA, particularly as a result of an increase in TOS.
AtıfScopus11WoS10OpenAlex10İncele - MakaleAçık Erişim2016Scopus SJRQ2Investigation of the inhibitory properties of some phenolic standards and bee products against human carbonic anhydrase I and II
Aygul, Imdat; Yaylaci Karahalil, Fatma; Supuran, Claudiu T.
Polyphenols are important secondary products of plants with the potential to inhibit carbonic anhydrases. The aim of this study was to investigate the inhibition effects of various phenolic standards, honey, propolis, and pollen species on human carbonic anhydrase I and II. The inhibition values (IC50) of the phenolics (gallic acid, protocatechuic acid, quercetin, catechin, tannic acid, and chrysin) ranged from 0.009 to 0.32 μg/mL, tannic acid emerging as the best inhibitor. The inhibition values of three different types of honey, heather, rhododendron, and chestnut ranged between 2.32 and 25.10 μg/mL, the chestnut honeys exhibiting the best inhibition. The ethanolic extracts of pollen and propolis exhibited good inhibitory properties, with IC50 values between 0.486 and 3.320 μg/mL. In order to evaluate the phenolic composition of bee products, phenolic profiles and total phenolic contents (TFC) were also measured. The inhibition ranking among the natural products studied was phenolic standards > propolis > pollen > honeys, and inhibition was related to TFC.
AtıfScopus13WoS12OpenAlex13İncele - MakaleYayıncıda açık erişim2016Scopus SJRQ3The effects of Co addition on the mechanical and microstructural properties of the matrix material of a Fe-based marble cutting tool
Budak, S.; Kaplan, M.
In this study, four different kinds of marble cutting matrices with a base composition of Fe-Cu-Sn and with variable amounts of Co powder were produced. For compaction, hot sintering process was carried out at 850°C under 35 MPa for 4 min. The mechanical and microstructural properties of the matrix materials were determined using SEM with EDS, three-point bending test, density and hardness measurement techniques. The addition of Co powders to the matrix and the subsequent hot sintering process affected the mechanical and microstructural properties of the cutting tool, such as hardness, total elongation, % porosity and phase distribution.
- MakaleYalnız künye2016Scopus SJRQ1Effect of seasonal changes on the combustion characteristics of impregnated cedar (Cedrus libani A. Rich.) wood
Fidan, M. Said; Yaşar, Ş. Şadiye; Yaşar, Mehmet; Atar, Musa; Alkan, Elif
Wood is an irreplaceable material used as decorative and structural element both indoors and outdoors. When used as a structural material, wood has several superior characteristics in comparison to other structural constituents, although it is adversely affected by fires as well as biotic pests and abiotic effects. In this study, cedar (Cedrus libani A. Rich.) wood samples were impregnated using either Tanalith-E or Wolmanit-CB as detailed in ASTM-D 1413-76 and surface-treated using water-based or synthetic varnish. The impregnated and varnished samples were left outdoors with the aim of investigating the effect of seasonal changes. The samples were later subjected to combustion analysis as detailed in the combustion test standard ASTM-E 160-50. The results of the study indicated that the weight loss was lower during winter (87.82%), for samples that were impregnated using Wolmanit-CB (88.90%) and those that were treated with synthetic varnish (88.45%). On the other hand the O2 and CO2 contents were determined to be the highest in fall during combustion without flame (18.16% and 17.96%, respectively); the CO content was the highest during combustion without flame for the winter samples (28,907 ppm) and the NO content was the highest during combustion without flame for the spring samples (76.15 ppm). In conclusion, the winter samples that were impregnated using Wolmanit-CB and treated with synthetic varnish were determined to be safer to employ in areas with high fire risk.
AtıfScopus6WoS9OpenAlex5İncele - MakaleYayıncıda açık erişim2016Scopus SJRQ1Organic geochemistry and element distribution in coals formed in eocene lagoon facies from the Eastern Black Sea Region,NE Turkey
Saydam Eker, Çiğdem; Akpinar, İbrahim; Sipahi, Ferkan
The amount and type,the inorganic element content,and the maturity of organic materials of Eocene coals,shaly coals,and coaly shales exposed in the Gümüşhane and Bayburt districts of the Eastern Black Sea Region of Turkey were investigated. The depositional environments and hydrocarbon potentials were also interpreted. The total organic carbon concentrations in the studied samples ranged from 0.50% to 63.08%. The samples from Özyurt,Kayadibi,and Tarhanas contained types II and III kerogen,and those from Sökmen and Manas contained type III kerogen. The samples contained Co,Cs,Ga,Hf,Th,U,Y,Mo,Be,Cd,Sb,and La,with average values similar to those of standard brown coals. The samples showed average contents of Co,Ga,Nb,Rb,V,Y,Cu,Pb,Zn,As,Be,and Se,similar to those of other Turkish coals. The sediment source of Eocene samples in the five areas was characterized by rocks with intermediate or mafic geochemical characteristics. The terrigenous/aquatic ratio of coal and shaly coal samples of the areas in question is >1. The sterane distribution was C29 > C28 > C27 and C29 > C27 > C28 for the Özyurt and Tarhanas areas,respectively. The average Tmax values for samples are between 424 °C and 460 °C. For samples Oz-1 and Ta-2,22S/(22S + 22R) homohopane (C32) ratios are 0.48 and 0.61,respectively; 20S/(20S + 20R) sterane (C29) ratios are 0.18 and 0.53,respectively; and Ts/(Ts + Tm) ratios are 0.015 and 0.64,respectively. The Pr/Ph ratios of the samples are >3. The studied samples have low sterane/hopane and high (C19+C20)/C23) ratios without anoxic biomarkers (17α(H)-28,30-bisnorhopane). Based on these data,the coals,shaly coals,and coaly shales were probably deposited under an oxic-suboxic mixture of marine and terrestrial environment conditions; these materials contain terrestrial organic matter and cannot generate hydrocarbon.
AtıfScopus15WoS16OpenAlex22TR Dizin4
İncele - MakaleAçık Erişim2016Scopus SJRQ2Optimum Tuning of a Gyroscopic Vibration Absorber Using Coupled Gyroscopes for Vibration Control of a Vertical Cantilever Beam
Ünker, F.; Çuvalci, O.
This paper deals with the investigation of optimum values of the stiffness and damping which connect two gyroscopic systems formed by two rotors mounted in gimbal assuming negligible masses for the spring, damper, and gimbal support. These coupled gyroscopes use two gyroscopic flywheels, spinning in opposing directions to have reverse precessions to eliminate the forces due to the torque existing in the torsional spring and the damper between gyroscopes. The system is mounted on a vertical cantilever with the purpose of studying the horizontal and vertical vibrations. The equation of motion of the compound system (gyro-beam system) is introduced and solved to find the response measured on the primary system. This is fundamental to design, in some way, the dynamic absorber or neutralizer. On the other hand, the effect of the angular velocities of the gyroscopes are studied, and it is shown that the angular velocity (spin velocity) of a gyroscope has a significant effect on the behavior of the dynamic motion. Correctness of the analytical results is verified by numerical simulations. The comparison with the results from the derivation of the corresponding frequency equations shows that the optimized stiffness and damping values are very accurate.
AtıfScopus4WoS2OpenAlex5İncele - MakaleAçık Erişim2016Scopus SJRQ1Comparison of practices related to occupational health and safety in microscale wood-product enterprises
Top, Yener; Adanur, Hakan; Öz, Mehmet
Risk factors in the workplace vary according to the sector and scale of the business. Small and medium-sized enterprises, especially those within the scope of the wood-products manufacturing industry, are considered to be risky, and have a relatively high accident rate. Here, we focus on the timber and furniture industries, two subsectors of the wood-products industry. A total of 47 enterprises was visited and asked to participate in a formal structured questionnaire. The findings show that the usage of personal protective equipment (PPE) was low, that lighting was often inadequate, and that these enterprises typically lacked routine organising and cleaning practices. The subsectors and the occupational health and safety practices were found to be independent, and a statistically significant relationship could only be established between the subsectors in terms of the use of dust masks and goggles. Despite the unfavourable working conditions, only one business out of 47 reported having an employee with symptoms of occupational diseases.
AtıfScopus33WoS30OpenAlex38İncele - MakaleAçık Erişim2016Scopus SJRQ2Investigation of pozzolanic activity of volcanic rocks from the northeast of the Black Sea
Çullu, Mustafa; Bolat, Hakan; Vural, Alaaddin; Tuncer, Ertan
Mineralogical and chemical properties, as well as the pozzolanic activities, of the volcanic rocks in the northeast of the Black Sea were examined. Physical and mechanical tests were conducted on samples collected from the study area and the feasibility of using volcanic rocks as pozzolanic admixture in the concrete industry was investigated. Mortar samples containing admixture in the ratios of 0%, 10%, 20%, 30%, 40%, and 50% were prepared by keeping fineness of pozzolanic admixtures fixed. By using these mortar samples, prismatic mortar samples of 4×4×16 cm were prepared and the samples were cured in water. Their 7-, 28-, and 90-day tensile strengths, compressive strengths, and ultrasonic pulse velocity were determined. As a result, it was determined that volcanic rocks can be used to produce blended cement by considering their specific gravity, pozzolanic activities, and compressive strengths. It was noted that increase in trass rate significantly reduced tensile and compressive strength of cement in the early stage as expected.
AtıfScopus18WoS15OpenAlex19İncele - MakaleYalnız künye2016Scopus SJRQ1Antiproliferative and proapoptotic activity of Turkish propolis on human lung cancer cell line
Demir, Selim; Aliyazicioglu, Yuksel; Turan, Ibrahim; Misir, Sema; Mentese, Ahmet; Yaman, Serap Ozer; Akbulut, Kubra; Kilinc, Kagan; Deger, Orhan
Cancer is a heterogeneous disease, two of whose characteristic features are uncontrollable cell proliferation and insufficient apoptosis. Various studies have investigated the antiproliferative effects of propolis, a natural bee product, from different countries, and its cytotoxic effects have been attributed to its polyphenol contents. The purpose of this study was to show the cytotoxic effects, and possible mechanisms involved, of ethanolic extract of Turkish propolis (EEP) on the human lung cancer (A549) cell line. Cytotoxic activity of EEP on A549 cells was revealed using the MTT assay. Mechanisms involved in the cytotoxic action of EEP on A549 cells were then investigated in terms of apoptosis, mitochondrial membrane potential and cell cycle using flow cytometry, endoplasmic reticulum stress using RT-PCR, and caspase activity using luminometric analysis. EEP exhibited selective toxicity against A549 cells compared to normal fibroblast cells. We determined that EEP arrested the cell cycle of A549 cells at the G1 phase, induced endoplasmic reticulum stress, caspase activity, and apoptosis and reduced mitochondrial membrane potential. These results indicate that Turkish propolis is capable of reducing cancer cell proliferation and may have a promising role to play in the development of new anticancer drugs in the future.
AtıfScopus102WoS105OpenAlex123İncele - Derleme MakaleAçık Erişim2016Scopus SJRQ1Higher PUFA and n-3 PUFA, conjugated linoleic acid, α-tocopherol and iron, but lower iodine and selenium concentrations in organic milk: a systematic literature review and meta- and redundancy analyses
Srednicka-Tober, Dominika; Baranski, Marcin; Seal, Chris J.; Sanderson, Roy; Benbrook, Charles; Steinshamn, Havard; Gromadzka-Ostrowska, Joanna; Rembialkowska, Ewa; Skwarlo-Sonta, Krystyna; Eyre, Mick
Demand for organic milk is partially driven by consumer perceptions that it is more nutritious. However, there is still considerable uncertainty over whether the use of organic production standards affects milk quality. Here we report results of meta-analyses based on 170 published studies comparing the nutrient content of organic and conventional bovine milk. There were no significant differences in total SFA and MUFA concentrations between organic and conventional milk. However, concentrations of total PUFA and n-3 PUFA were significantly higher in organic milk, by an estimated 7 (95% CI -1, 15)% and 56 (95% CI 38, 74) %, respectively. Concentrations of alpha-linolenic acid (ALA), very long-chain n-3 fatty acids (EPA + DPA + DHA) and conjugated linoleic acid were also significantly higher in organic milk, by an 69 (95% CI 53, 84) %, 57 (95% CI 27, 87)% and 41 ( 95% CI 14, 68) %, respectively. As there were no significant differences in total n-6 PUFA and linoleic acid (LA) concentrations, the n-6:n-3 and LA: ALA ratios were lower in organic milk, by an estimated 71 (95% CI -122, -20)% and 93 (95% CI -116, -70) %. It is concluded that organic bovine milk has a more desirable fatty acid composition than conventional milk. Meta-analyses also showed that organic milk has significantly higher alpha-tocopherol and Fe, but lower I and Se concentrations. Redundancy analysis of data from a large cross-European milk quality survey indicates that the higher grazing/conserved forage intakes in organic systems were the main reason for milk composition differences.
AtıfScopus197WoS154OpenAlex212İncele - Derleme MakaleAçık Erişim2016Scopus SJRQ1Composition differences between organic and conventional meat: a systematic literature review and meta-analysis
Srednicka-Tober, Dominika; Baranski, Marcin; Seal, Chris; Sanderson, Roy; Benbrook, Charles; Steinshamn, Havard; Gromadzka-Ostrowska, Joanna; Rembialkowska, Ewa; Skwarlo-Sonta, Krystyna; Eyre, Mick
Demand for organic meat is partially driven by consumer perceptions that organic foods are more nutritious than non-organic foods. However, there have been no systematic reviews comparing specifically the nutrient content of organic and conventionally produced meat. In this study, we report results of a meta-analysis based on sixty-seven published studies comparing the composition of organic and non-organic meat products. For many nutritionally relevant compounds (e.g. minerals, antioxidants and most individual fatty acids (FA)), the evidence base was too weak for meaningful meta-analyses. However, significant differences in FA profiles were detected when data from all livestock species were pooled. Concentrations of SFA and MUFA were similar or slightly lower, respectively, in organic compared with conventional meat. Larger differences were detected for total PUFA and n-3 PUFA, which were an estimated 23 (95% CI 11, 35)% and 47 (95% CI 10, 84)% higher in organic meat, respectively. However, for these and many other composition parameters, for which meta-analyses found significant differences, heterogeneity was high, and this could be explained by differences between animal species/meat types. Evidence from controlled experimental studies indicates that the high grazing/forage-based diets prescribed under organic farming standards may be the main reason for differences in FA profiles. Further studies are required to enable meta-analyses for a wider range of parameters (e.g. antioxidant, vitamin and mineral concentrations) and to improve both precision and consistency of results for FA profiles for all species. Potential impacts of composition differences on human health are discussed.
AtıfScopus180WoS156OpenAlex225İncele - MakaleYalnız künye2016Scopus SJRQ1A study to develop clinical decision rules for the use of radiography in wrist trauma: Karadeniz wrist rules
Karaca, Yunus; Turkmen, Suha; Cansu, Aysegul; Baki, Mehmet Emre; Eroglu, Oguz; Tatli, Ozgur; Gunaydin, Mucahit; Beyhun, Ercument; Gunduz, Abdulkadir; Eryigit, Umut
Introduction: The aim of this study was to evaluate patients presenting to the emergency department (ED) with wrist trauma using physical examination findings and functional tests and to identify findings with high sensitivity and specificity among the parameters assessed in patients with fracture in the wrist. The ultimate objective was thus to establish a reliable and widely usable clinical decision rule for determining the necessity of radiography in wrist trauma. Methods: This prospective, multicenter study was performed in 8 hospitals. The relation between radiologically determined fracture and clinical findings consisting of physical examination findings and functional tests was assessed in terms of whether or not these were markers of radiography requirement, with the aim of identifying predictive values for fracture. Results: A total of 603 eligible trauma patients presented to the participating EDs during the study period. Fracture was identified in 24.5% of patients (n= 148). The 4-way combination with the highest sensitivity was identified as axial compression and the positive distal radioulnar drawer test, and pain with radial deviation and dorsal flexion. Sensitivity at distal ulna palpation was added as a fifth parameter, and sensitivity and negative predictive value thus increased to 100%. Conclusion: With their 100% sensitivity and 100% negative predictive values, the Karadeniz wrist rules may represent a clinical decision rule that can be used in practice in EDs. If all 5 findings are negative, there is no indication for wrist radiography. (C) 2016 Elsevier Inc. All rights reserved.
AtıfWoS8OpenAlex11İncele - MakaleAçık Erişim2016Scopus SJRQ1Regulators of mitochondrial complex I activity: A review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder
Duong, Angela; Che, Yi; Ceylan, Deniz; Pinguelo, Arsene; Andreazza, Ana C.; Young, L. Trevor; Berk, Michael
Phenomenologically, bipolar disorder (BD) is characterized by biphasic increases and decreases in energy. As this is a state-related phenomenon, identifying regulators responsible for this phasic dysregulation has the potential to uncover key elements in the pathophysiology of BD. Given the evidence suggesting mitochondrial complex I dysfunction in BD, we aimed to identify the main regulators of complex I in BD by reviewing the literature and using the published microarray data to examine their gene expression profiles. We also validated protein expression levels of the main complex I regulators by immunohistochemistry. Upon reviewing the literature, we found PARK-7, STAT-3, SIRT-3 and IMP-2 play an important role in regulating complex I activity. Published microarray studies however revealed no significant direction of regulation of STAT-3, SIRT-3, and IMP-2, but a trend towards downregulation of PARK 7 was observed in BD. Immunocontent of DJ-1 (PARK-7-encoded protein) were not elevated in post mortem prefrontal cortex from patients with BD. We also found a trend towards upregulation of DJ-1 expression with age. Our results suggest that DJ-1 is not significantly altered in BD subjects, however further studies are needed to examine DJ-1 expression levels in a cohort of older patients with BD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
AtıfWoS10OpenAlex12İncele - MakaleYalnız künye2016Scopus SJRQ3Preventing Suture Extrusion and Recurrence in Mustarde and Furnas Otoplasties by Using Laterally Based Postauricular Dermal Flap, Long-Term Results
Basat, Salih Onur; Ceran, Fatih; Askeroglu, Ufuk; Aksan, Tolga; Orman, Cagdas; Yazar, Memet; Uscetin, Ilker; Akan, Mithat; Bozkurt, Mehmet
Background:Prominent ear deformity (PD) is an unacceptable condition of pinna that affects 5% of the population and is associated with emotional stress, behavioral disturbances, and social restrictions in relationships. Conchal hypertrphy, inadequate formation of antihelical fold, earlobe placement ahead than it should be, or various combinations of these changes are main characteristics of PD. Many surgical techniques have been described for the PD.The authors' aim was to present laterally based postauricular dermal flap combination with cartilage-sparing methods and effectiveness of this technique in suture extrusion prevention and reducing the rate of recurrence with long-term results.Methods:Forty-one patients had bilateral and 6 patients had unilateral PD, a total of 47 patients with a mean age of 14.48 were operated by using this combined procedure. A laterally based supraperichondrial dermal flap was prepared from a deepithelized elliptical postauricular incision. Mustarde and Furnas suture techniques were used solely for PD correction. The dissected laterally based dermal flap was fixed to the mastoid bone with sutures in stretched position after reshaping the auricular cartilage with sutures.Results:The average helix-mastoid distance was (mm) 16.282.36, concha-mastoid angle was 25.71 +/- 0.96 degrees on 12-month measurements. The helix-mastoid distance showed an increase of 1 to 3mm, in the concha-mastoid angle measurements of 1 degrees to 2 degrees. Statistically significant changes were observed between the average preoperative, postoperative 1. month, postoperative 12. month helix-mastoid distances (mm), and month concha-mastoid angle (degrees) measurements (P=0.0001).Conclusions:The laterally based postauricular dermal flap technique is an effective method to prevent suture extrusion and recurrence which are the most important complications of otoplasty procedure and easy to apply.
AtıfWoS15OpenAlex15İncele - MakaleAçık Erişim2016Scopus SJRQ2Acetylcholinesterase and carbonic anhydrase isoenzymes I and II inhibition profiles of taxifolin
Gocer, Hulya; Topal, Fevzi; Topal, Meryem; Küçük, Murat; Teke, Dilek; Gülçin, Ilhami; Alwasel, Saleh H.; Supuran, Claudiu T.
Taxifolin, also known as dihydroquercetin, is a flavonoid commonly found in plants. Carbonic anhydrase (CA, EC 4.2.1.1) plays an important role in many critical physiological events including carbon dioxide (CO2)/bicarbonate (HCO3-) respiration and pH regulation. There are 16 known CA isoforms in humans, of which human hCA isoenzymes I and II (hCA I and II) are ubiquitous cytosolic isoforms. In this study, the inhibition properties of taxifolin against the slow cytosolic isoenzyme hCA I, and the ubiquitous and dominant rapid cytosolic isoenzyme hCA II were studied. Taxifolin, as a naturally bioactive flavonoid, has a K-i of 29.2nM against hCA I, and 24.2nM against hCA II. For acetylcholinesterase enzyme (AChE) inhibition, K-i parameter of taxifolin was determined to be 16.7nM. These results clearly show that taxifolin inhibited both CA isoenzymes and AChE at the nM levels.
AtıfScopus138WoS131OpenAlex133İncele - MakaleYalnız künye2016Scopus SJRQ2Mean platelet volume is related with ischemic stroke in patients with sinus rhythm
Özkan, Bugra; Arik, Osman Z.; Gözükara, Mehmet Y.; Sahin, Durmus Y.; Topal, Salih; Uysal, Onur K.; Elbasan, Zafer; Epçeliden, Tuncay; Çayil, Murat; Gür, Mustafa
Stroke is the leading cause of disability worldwide. It is known that atrial fibrillation and left atrial enlargement contribute ischemic stroke, and mean platelet volume (MPV) increases in patients with ischemic stroke and atrial fibrillation. We aimed to determine whether higher MPV is associated with ischemic stroke in patients with sinus rhythm. We evaluated 74 patients in sinus rhythm and with ischemic stroke (Group 1) and 90 age-matched and sex-matched healthy individuals as control group (Group 2). After physical and echocardiographic examination, 24-48 h Holter monitoring and complete blood counts were studied. There were no statistically significant differences in age, sex rates, and comorbidities between groups. Left atrial diameter was higher in Group 1 than Group 2 (P=0.001), but both were in normal range. MPV was significantly higher in Group 1 (P<0.001) and was an independent determinant [odds ratio (OR): 1.840; P<0.001; 95% confidence interval (CI) 1.330-2.545] of ischemic stroke with left atrial (OR: 1.138; P=0.006; 95% CI 1.037-1.248). In conclusion, higher MPV is associated with acute ischemic stroke in patients with sinus rhythm and without heart failure or left atrial enlargement. MPV and left atrial diameter are independent predictors of ischemic stroke in this patient population. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
AtıfWoS11OpenAlex13İncele - MakaleYayıncıda açık erişim2016Scopus SJRQ2Comparison of Effects of Separate and Combined Sugammadex and Lipid Emulsion Administration on Hemodynamic Parameters and Survival in a Rat Model of Verapamil Toxicity
Tulgar, Serkan; Kose, Halil Cihan; Piroglu, Isilay Demir; Karakilic, Evvah; Ates, Nagihan Gozde; Demir, Ahmet; Gergerli, Ruken; Guven, Selin; Piroglu, Mustafa Devrim
Background: Toxicity of calcium channel blockers leads to high patient mortality and there is no effective antidote. The benefit of using 20% lipid emulsion and sugammadex has been reported. The present study measured the effect of sugammadex and 20% lipid emulsion on hemodynamics and survival in a rat model of verapamil toxicity. Material/Methods: In this single-blinded randomized control study, rats were separated into 4 groups of 7 rats each: Sugammadex (S), Sugammadex plus 20% lipid emulsion (SL), 20% lipid emulsion (L), and control (C). Heart rates and mean arterial pressures were monitored and noted each minute until death. Results: Average time to death was 21.0 +/- 9.57 minutes for group C, 35.57 +/- 10.61 minutes for group S, 37.14 +/- 16.6 minutes for group L and 49.86 +/- 27.56 minutes for group SL. Time to death was significantly longer in other groups than in the control group (p<0.05). Conclusions: Verapamil overdose is has a comparatively high mortality rate and there is no effective antidote. Treatment generally involves gastric decontamination and symptomatic treatment to counteract the drug's negative effects. In animal studies sugammadex and lipid emulsion had a positive effect on survival in patients with calcium channel blocker toxicity. Sugammadex and intralipid increased survival in a rat model of verapamil toxicity. The combination of both drugs may decrease cardiotoxicity. Sugammadex alone or combined with 20% lipid emulsion reduce the need for inotropic agents. The mechanism requires clarification with larger studies.
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