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• Çocuk Bakımı ve Gençlik Hizmetleri Bölümü
• Tıbbi Hizmetler ve Teknikler Bölümü

Araştırmacılar(16)

• Akan, Yunus Emre
• Caner, Zafer
• Cin, Aynur
• Coşar, Dilan Aktepe
• Demirağ, Hatice
• Erkuran, Hatun
• Göger, Berrin
• Günay, Ayşe Rüveyde
• Hançer, Buse
• Inal, Ebru
• Kurnaz, Muammer
• Örnek, Hikmet Fırat
• Özatman, Savaş
• Tuç, Adile
• Türkmen, Osman Oğulcan
• Yurdusever, Taner

• Derleme MakaleAçık Erişim2026/r/gumushane/16347
  Nanoplastic Translocation Across Biological Barriers (Blood-Brain, Placental, Intestinal): Transport Mechanisms, Tissue-Specific Vulnerabilities, and a Corona-Driven Barrier Selectivity Framework

  Berber, Ahmet Ali; Yildiz, Esra; Berber, Nurcan; Kurnaz, Muammer; Kenanoglu, Nihan Akinci

  Nanoplastics (NPs; <= 1 & micro;m) have been detected in human placenta, blood, lung, atherosclerotic plaque, testis, semen, olfactory bulb, and brain, shifting the field from environmental description toward mechanistic interrogation of barrier crossing. This review synthesises current evidence on NP translocation across the intestinal epithelium, the blood-brain barrier (BBB) and the placental syncytiotrophoblast. We distinguish four evidence categories throughout the review: detection, association, mechanism, and causality. We also apply model-system labels (in silico, in vitro, ex vivo, animal, and human) to every mechanistic claim, so that the strength of each statement can be read off directly. Most current studies use pristine polystyrene nanoplastics at concentrations 3-6 orders of magnitude above plausible human exposure, so the mechanistic conclusions below are hypothesis-generating for human disease rather than definitive. We propose a working conceptual framework-corona-driven barrier selectivity (CDBS)-in which the particle-corona-surface complex, rather than the bare polymer, is hypothesised to dictate which receptor and transport machinery (TfR1, LRP1, FcRn, P-gp/BCRP, caveolae) each barrier engages. CDBS is offered as a hypothesis-stage organising tool requiring experimental validation, not as an established mechanism. We outline reported transport modes, including clathrin- and caveolin-mediated endocytosis, paracellular leakage via ROS-induced tight-junction disassembly, receptor-mediated transcytosis, and the candidate olfactory route. We emphasise that pristine polystyrene-bead doses commonly exceed plausible human exposure by 3-6 orders of magnitude, that detection methods underestimate sub-micrometre particles, and that causal links between NPs and human disease remain hypothesis-generating. A research agenda built on weathered reference materials, microphysiological systems, and integrative human biomarker science is proposed.

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• DüzeltmeAçık Erişim2026/r/gumushane/10683
  Ethical Principles and Frameworks in Dementia Care: A Scoping Review (vol 19, 29, 2026)

  Serrat, Rodrigo; Lauridsen, Sigurd; Bobrowicz-Campos, Elzbieta; Brandao, Tania; Brites, Rute; Cannella, Valentina; Celdrán, Montserrat; Chacur-Kiss, Karima; Cin, Aynur; Faba, Josep

  Unfortunately, this article was published online with errors—the blinded names were not replaced. The corrected sentence is shown below. FROM: Step 2: Identifying Relevant Studies With the support of BLINDED FOR REVIEW, a professional librarian at the University of BLINDED FOR REVIEW, we developed and refined our search strategy through an iterative process involving the selection of both keywords and databases. TO: Step 2: Identifying Relevant Studies With the support of Joan Pons-Vila, a professional librarian at the University of Barcelona, we developed and refined our search strategy through an iterative process involving the selection of both keywords and databases.

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• Derleme MakaleAçık Erişim2026/r/gumushane/16327
  Microplastic Contamination in Amphibians and Reptiles: An Ecotoxicological Synthesis of Exposure, Mechanisms, and Risk Implications

  Berber, Ahmet Ali; Akbulut, Cansu; Demir, Sefika Nur; Kurnaz, Muammer

  Microplastic (MP) contamination has become a defining feature of twenty-first century environmental change, yet the toxicological and ecological consequences for amphibians and reptiles-two vertebrate classes already facing severe extinction pressures-remain fragmented across taxa, regions, and methodological traditions. Here, we synthesize field and experimental evidence from five continents to provide a taxonomically balanced, mechanistically grounded, and geographically explicit assessment of MP exposure, bioaccumulation, and toxicity in herpetofauna, drawing on a structured literature search in Web of Science, Scopus, and PubMed (January 2015-March 2026). Field detection rates of MPs in amphibian larvae range from 26% in conservatively screened Central European populations to 73-80% in anuran tadpoles from high-anthropogenic-pressure Anatolian catchments, with fibrous polyethylene terephthalate (PET), polyethylene (PE), and polypropylene (PP) particles dominating the detected burden. Mechanistic evidence converges on oxidative stress cascades, hypothalamic-pituitary-thyroid axis disruption, gut and cutaneous microbiome dysbiosis, and compromised antiviral and antifungal immunity, with the latter potentially amplifying vulnerability to Batrachochytrium dendrobatidis and to ranavirus. Among reptiles, sea turtles display near-universal MP ingestion with documented maternal transfer to eggs; freshwater turtles, terrestrial squamates, and crocodilians remain critically understudied. Three structural asymmetries constrain current ecotoxicological risk characterization: taxonomic bias toward anurans and sea turtles, geographic bias toward the Global North, and experimental bias toward acute, supra-environmental laboratory exposures using pristine, single-polymer particles that fail to capture the chemical complexity of weathered field mixtures. We argue that MP burden may warrant consideration as a candidate stressor criterion within IUCN Red List assessments and within environmental risk assessment frameworks for freshwater and terrestrial biodiversity once a robust quantitative relationship between MP burden and demographic decline or population-level fitness has been established, and propose six hypothesis-driven research priorities: methodological standardization, reptile toxicokinetics, transgenerational epigenetics, MP-pathogen microbiome interactions and their translation into population viability models, temperature & times; MP interaction under climate warming, and population-genetic consequences of contemporary MP-driven selection, as the most tractable avenues for ecotoxicological progress and for the development of herpetofauna-specific risk characterization frameworks.

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• MakaleAçık Erişim2026/r/gumushane/10686
  Ethical Principles and Frameworks in Dementia Care: A Scoping Review

  Serrat, Rodrigo; Lauridsen, Sigurd; Bobrowicz-Campos, Elzbieta; Brandao, Tania; Brites, Rute; Cannella, Valentina; Celdrán, Montserrat; Chacur-Kiss, Karima; Cin, Aynur; Fabà, Josep

  Providing ethical care for people living with dementia is essential for safeguarding their rights, dignity, and well-being. However, ethical decision-making in dementia care is complex, often involving tensions between competing moral claims such as autonomy, beneficence, nonmaleficence, justice, and non-discrimination. This scoping review aimed to map and describe the ethical principles, related normative considerations, and ethical frameworks discussed in the scientific literature on dementia care, and to identify how these have been conceptualized. Following the methodological guidance of Arksey and O'Malley (2005), Levac et al. (2010), and Peters et al. (2021, 2022), a comprehensive search across five databases (Web of Science, Scopus, CINAHL, Medline/PubMed, and PsycInfo) identified peer-reviewed papers published in English. In total, 388 papers published between 1981 and 2024 were included. The results revealed a wide range of ethical principles and related normative considerations frequently cited in the literature, although they were typically discussed in an isolated way without reference to other principles or broader ethical frameworks. In contrast, ethical frameworks were mentioned far less often, and when they were, they mostly reflected traditional approaches such as principlism. Four gaps were identified: the plurality of ethical frameworks and limited conceptual integration underpinning dementia care research and practice; insufficient attention to ethnic and socioeconomic diversity among people living with dementia; limited consideration of diverse care settings and geographical regions; and the limited inclusion of people living with dementia themselves in the studies reviewed. These findings underscore the need for conceptually integrative, inclusive, and context-sensitive approaches to dementia care ethics that can better inform both ethical reflection and care practices.

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• MakaleAçık Erişim2026/r/gumushane/16649
  Examination of Health-Seeking Behavior in Individuals with Chronic Diseases

  Cosar, Dilan Aktepe; Demirag, Hatice; Cin, Aynur

  Background: Chronic illnesses are long-term, noncommunicable diseases that significantly affect daily life. In addition to physical symptoms, they can reduce quality of life by causing psychological effects such as anxiety and depression. Patients often seek health information to better manage their condition. Methods: This study aimed to examine the level of health information-seeking behavior among individuals with chronic diseases and the factors influencing this behavior. The sample group for this descriptive study consisted of 306 individuals with chronic illnesses who visited X Hospital in northeastern T & uuml;rkiye between April 1, 2024, and February 1, 2025. All individuals completed a questionnaire consisting of the Patient Information Form and the Health Seeking Behavior Scale. Results: The sociodemographic characteristics of patients with chronic diseases, such as education level, marital status, and chronic disease duration, significantly affected the health-seeking behavior scores. According to the research findings, the highest mean score was determined as 12.30 +/- 2.62 in the occupational health-seeking subdimension, whereas the lowest mean score was determined as 8.78 +/- 3.83 (min-max: 3-15) in the traditional health-seeking subdimension. The total mean score of the Health Seeking Behavior Scale was 32.2 7 +/- 7.73. Conclusions: Individuals with chronic illnesses tend to prefer professional health care services when seeking health-related behaviors. Health-seeking behaviors were higher among high school graduates, single individuals, and those without chronic illnesses.

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• MakaleYalnız künye2026/r/gumushane/19411
  Tip 2 Diyabet Mellituslu Bireylerde Diyabet Farkındalığı ve Kabul Düzeyleri ile Sağlık Okuryazarlığı Arasındaki İlişki: Tanımlayıcı-Kesitsel Bir Çalışma

  Demirağ, Hatice; Cosar, Dilan Aktepe; Aktepe, Yusuf

  Amaç: Bu çalışma, Tip 2 diyabetli hastalarda diyabet farkındalığı ve kabul düzeyleri ile sağlık okuryazarlığı arasındaki ilişkiyi incelemektedir. Gereç ve Yöntemler: Çalışma, 15 Temmuz 2025 ile 15 Kasım 2025 tarihleri arasında Türkiye'nin kuzeydoğusundaki hastane ve kliniklere başvuran ayakta tedavi gören hastalar arasında kesitsel bir çalışma olarak yürütülmüştür. Katılımcılar 18 yaş ve üzeri olup tip 2 diyabet hastasıydı; gebelik diyabeti olanlar veya anketi tamamlayamayanlar çalışmadan dışlanmıştır. Veriler, Hasta Bilgi Formu, Diyabet Farkındalığı ve Kabul Ölçeği (DAAS) ve E-Sağlık Okuryazarlığı Ölçeği (EHLS) kullanılarak yüz yüze görüşmeler yoluyla toplanmıştır. Tanımlayıcı istatistikler, bağımsız örneklem t-testleri, ANOVA ve Pearson korelasyon analizleri kullanılmıştır. Bulgular: Katılımcıların ortalama yaşı 56,2±14,9 yıl; %62,7'si kadındı. Ortalama DAAS ve EHLS puanları sırasıyla 81,6±18,7 ve 22,1±8,3 idi. Erkekler ve bekar bireylerin EHLS puanları daha yüksekti; daha yüksek eğitim düzeyi daha yüksek EHLS puanlarıyla ilişkiliydi. DAAS puanları hastalık süresiyle artarken, EHLS puanları yaş ve daha uzun hastalık süresiyle azaldı. Tüm DAAS alt ölçekleri ile EHLS arasında pozitif korelasyonlar gözlendi. Birçok katılımcı, çevrimiçi sağlık bilgisi edinmeye yönelik belirsizlik veya olumsuz tutumlar ifade etti. DAAS farkındalık alt ölçeği, DAAS kabul alt ölçeği ve DAAS toplam puanı ile EHLS toplam puanı arasında pozitif ve anlamlı bir korelasyon bulunmuştur (p<0.001). Sonuç: Çalışma, Tip 2 diabetes mellituslu bireylerde diyabet farkındalığı, kabulü ve e-sağlık okuryazarlığı arasında pozitif ve anlamlı bir korelasyon bulmuştur. Yaş, eğitim, medeni durum, hastalık süresi, genel sağlık algısı, aile öyküsü ve beslenme alışkanlıklarının bu değişkenler üzerinde etkili olabileceği bulunmuştur.

  İncele
• MakaleAçık Erişim2026/r/gumushane/19358
  Ergenlerde Akıllı Telefon Bağımlılığı İle Sosyal Kaygı Arasındaki İlişki: Çoklu Aracılık Modeli

  Alsaç, Selda Yüzer; Türkmen, Osman Oğulcan; Tuncay, Birgül

  Bu çalışma, ergenlerde akıllı telefon bağımlılığı ile sosyal kaygının alt boyutları arasındaki ilişkiyi, bir çoklu aracılık modelini test ederek incelemiştir. Tanımlayıcı-kesitsel desende yürütülen araştırmanın verileri, 306 lise öğrencisinden toplanmıştır. Bulgular, akıllı telefon bağımlılığı ile sosyal kaygının kilit boyutları arasında anlamlı ilişkiler olduğunu göstermiştir. Çoklu aracılık analizi sonucunda, sosyal kaygının bilişsel temelini oluşturan olumsuz değerlendirilme korkusu ile akıllı telefon bağımlılığı arasındaki ilişkide, yeni sosyal durumlardaki korku ve huzursuzluk duyma alt boyutunun tam aracı rol üstlendiği belirlenmiştir. Buna karşın, genel sosyal durumlardaki korku ve huzursuzluk duyma alt boyutunun bu ilişkide aracı bir rolü olmadığı saptanmıştır. Cinsiyetin bağımlılık düzeylerinde anlamlı bir faktör olmadığı görülürken, kişisel telefon sahipliği ve kullanım süresine göre bağımlılık düzeyleri farklılaşmaktadır. Bu sonuçlar, olumsuz değerlendirme korkusunun bağımlılığa giden yolu özellikle yeni sosyal durumlara karşı duyulan kaygı üzerinden tetiklediğini gösteren aracılık modelini desteklemektedir. Sonuç olarak bu çalışma, sosyal kaygıyı ele alan psikoeğitim programlarının, bu popülasyondaki sorunlu akıllı telefon kullanımını azaltmak için etkili bir strateji olabileceğini vurgulamaktadır.

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• MakaleYalnız künye2026/r/gumushane/14198
  Impact of stress ball intervention on satisfaction, comfort and anxiety in hemodialysis patients: a randomized controlled trial

  Salti, Aysun Kazak; Topali, Hasret; Turkmen, Osman Oğulcan

  Hemodialysis (HD) patients commonly experience psychological distress and anxiety, which may affect their comfort and satisfaction during treatment. This study examined the overall impact of stress ball use on satisfaction, comfort, and anxiety among individuals receiving HD. A total of 46 patients were randomized between January and July 2025. Three participants in the intervention group withdrew before completing the study; therefore, the final analysis included 43 patients (20 in the stress ball group and 23 in the control group). Data were collected using the Patient Information Form (PIF), Visual Analog Patient Satisfaction Scale (VAPSS), Hemodialysis Comfort Scale (HCS), Distress Thermometer (DT), and Visual Analog Scale for Anxiety (VAS-A). Patients in the intervention group used a stress ball for at least 15 minutes during each of twelve HD sessions. Measurements were obtained at baseline, midpoint, and post-test, while the control group received standard care and was assessed concurrently. The study findings demonstrated that anxiety levels decreased over time in the stress ball group, whereas they increased in the control group. Similarly, distress levels decreased in the stress ball group, while no significant change was observed in the control group. HD comfort scores decreased in the stress ball group but increased in the control group. In contrast, no statistically significant difference was found between the groups in terms of the VAPSS scores. These results highlight the potential value of simple distraction techniques in clinical settings for further improving psychological outcomes.

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• MakaleYalnız künye2026/r/gumushane/13898
  Determinants of sleep quality and fatigue in patients undergoing hemodialysis

  Kazak Salti, Aysun; Topali, Hasret; Türkmen, Osman Oğulcan

  Aim: This research aimed to evaluate sleep quality and fatigue among individuals undergoing hemodialysis and to explore the determinants affecting these variables. Methods: This observational investigation was carried out among 78 who were regularly receiving hemodialysis therapy. The research was carried out between May and October 2025 in three different public hospitals among individuals undergoing hemodialysis treatment. Data were gathered using the Patient Information Form (PIF), the Fatigue Severity Scale (FSS), and the Pittsburgh Sleep Quality Index (PSQI). Results: The mean score of the hemodialysis patients on the FSS is 4.97 ± 1.11, and the mean PSQI value is 7.76 ± 3.64. A moderately positive and statistically noteworthy relation was observed between the PSQI and FSS scores. Additionally, a low negative meaningful correlation was seen between ferritin levels and the FSS scores, as well as between calcium levels and the PSQI scores. The use of medications related to chronic disease and the PSQI scores were identified as significant predictors of the FSS scores. Conclusion: Fatigue and sleep quality in individuals receiving hemodialysis treatment are related to each other, as well as to biochemical balance and treatment adherence.

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• MakaleYalnız künye2026/r/gumushane/13873
  Effects of a puppet-assisted house-tree-person test on fear and anxiety in children receiving chemotherapy and associated influencing factors: A projective, quasi-experimental study

  KAHRIMAN, Ilknur; AKSOY, Bahar; KANDAZ, Ufuk; BORAN, Serpil; GÖGER, Berrin; KIRBAŞ, Zila Özlem

  Objectives This study investigated the effect of the puppet-assisted House-Tree-Person Test (HTP-T) on fear and anxiety levels in children undergoing chemotherapy treatment and the factors influencing these outcomes. Methods The study employed a one-group pretest–posttest quasi-experimental design combined with HTP-T analysis. The study was conducted with 29 children aged 5–12 years receiving chemotherapy at the pediatric hematology-oncology outpatient clinics of a university hospital in the Eastern Black Sea Region of Türkiye during the 2022–2024 years. Data were collected using “the Demographic Information Form for Children and Parents, the Children's State Anxiety Scale (CSA), the Children's Fear Scale (CFS), and HTP-T". Data analysis was performed using descriptive statistics, repeated measures ANOVA, and HTP-T analysis. Results Statistically significant differences were observed in children's mean CSA (F = 3.898, p = 0.026, η2 = 0.122) and CFS (F = 5.313, p = 0.008, η2 = 0.159) scores across the pre-treatment, during-treatment, and post-treatment measurements. The HTP-T analysis revealed that children had difficulty regulating anxiety and fear, expressed concerns about family and environmental events, reported feelings of loneliness, and exhibited strong emotional attachment to their families. Conclusion The study demonstrated that incorporating puppet-assisted HTP-T during chemotherapy contributed to reducing children's fear and anxiety and offered a useful approach for identifying influencing factors. Implications for nursing practice HTP-T, a therapeutic play technique incorporating puppetry and projective methods, may be effective in reducing fear and anxiety among children undergoing chemotherapy.

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