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- MakaleAçık Erişim2026Scopus SJRQ3Mono- and Bis-Ureido Sulfapyridines as Nanomolar Dual Cholinesterase Inhibitors: Enzyme Kinetics, Molecular Docking, and ADME/Tox Insights
Yapar, Gonul; Akocak, Suleyman; Lolak, Nebih; Topal, Meryem; Türkes, Cuneyt; Topal, Fevzi; Durgun, Mustafa; Koçyigit, Umit Muhammet; Isik, Mesut; Beydemir, Sukru
A series of mono- and bis-ureido sulfapyridine derivatives (SP-1-SP-10) were synthesized and evaluated as dual cholinesterase inhibitors targeting acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). All compounds exhibited nanomolar inhibition. The most potent AChE inhibitors were SP-8 (K-i = 5.25 +/- 0.73 nM), SP-9 (5.09 +/- 0.44 nM), and SP-10 (5.74 +/- 0.55 nM), significantly outperforming tacrine (K-i = 105.03 +/- 8.85 nM) under identical conditions. For BChE, SP-9 showed the strongest inhibition (K-i = 26.38 +/- 2.07 nM) compared with tacrine (172.03 +/- 32.42 nM). Kinetic analyses revealed competitive inhibition toward AChE for all derivatives, whereas BChE inhibition displayed both competitive and noncompetitive patterns depending on structural features. Glide XP docking using AChE (PDB: 7XN1) and BChE (PDB: 4BDS), complemented by MM-GBSA binding free energy calculations, supported favorable ligand accommodation within the catalytic pockets and highlighted the importance of aromatic and hydrophobic interactions. In silico ADME/Tox analysis revealed a potency-drug-likeness trade-off: mono-ureido derivatives complied with Lipinski's rule of five and showed high predicted oral absorption, whereas bis-ureido derivatives, despite superior enzymatic potency, exhibited multiple drug-likeness violations. These findings identify the ureido-sulfapyridine scaffold as a potent enzymatic dual cholinesterase inhibitory framework, warranting further structural optimization to improve pharmacokinetic properties.
- MakaleAçık Erişim2023Scopus SJRQ3Relationship of progranulin response with some physio-biochemical parameters in Akkaraman sheep
Bayraktar, Buelent; Tekce, Emre; Genç, Murat; Kaya, Hacer; Özcan, Gulbahar Boyuk; Aydemir, Seyma; Kotan, Goksad Cemil; Takma, Cigdem; Ürüsan, Hilal; Aksakal, Vecihi
Progranulin (PGRN) is a multifunctional protein that is critical in the retention of embryos in the endometrium of the uterus and the protection of cervical tissue during fetal growth. In case of PGRN release and dysfunction, cervical tissue may remodel (regeneration) and lead to the risk of abortion. Serum PGRN level in sheep and its variation according to different physiological periods and its relationship with some biochemical parameters are unknown. In this study, the relationship between early lactation, early and late pregnancy serum PGRN levels and some biochemical parameters in Akkaraman sheep was investigated for the first time. In the literature search, no similar studies were found on the relationship between early lactation, early and late pregnancy serum PGRN levels and some biochemical parameters in Akkaraman sheep. The research was carried out on 90 Akkaraman sheep reared in the same herd under the same care and feeding conditions. In the study, Akkaraman ewe were divided into 3 groups as early lactation, early pregnancy and late pregnancy. 1st group is early lactation period ewe (first 60 days of lactation), (n = 30), 2nd group is in the first period of pregnancy (on the 0-90th day of the first pregnancy (n = 30)), 3rd group is in the late pregnancy of pregnancy (100-150 days of pregnancy (n = 30)) was created. Blood samples from vena jugularis were taken before morning feeding from the animals that formed the study groups. PGRN levels in serum were determined by ELISA method. In addition, glucose, calcium (Ca), magnesium (Mg), phosphorus (P), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), very low density lipoprotein (VLDL) levels were analyzed in biochemistry autoanalyzer. As a result of the study, lactation and early pregnancy and late pregnancy mean serum PGRN levels were determined as 1.93, 1.78, 1.33 ng mL-1, respectively. The serum PGRN, glucose, Ca, Mg, P, TC, TG, LDL, HDL and VLDL levels of sheep with late pregnancy, early lactation and early pregnancy periods, which constitute the study groups, were found to be statistically significant (P<0.05). Our results have shown that due to the physiological role of PRGN in keeping the embryo in the endometrium of the uterine and in preserving the cervical tissue during fetal growth, there may be a useful parameter in the pursuit of the pregnancy process.
- MakaleAçık Erişim2025Scopus SJRQ1A hybrid decision support system for transport policy selection: A case study on Russia's Northern Sea route in Artic region
Yalçin, Galip Cihan; Limon, Elif Gurdal; Kara, Karahan; Limon, Onur; Gürol, Pinar; Deveci, Muhammet; Demirayak, Ozgur; Tomáková, Hana
The selection of transport policies by countries is critical both for international relations and for the implementation of effective and sustainable transport practices. Countries consider numerous parameters when deciding on transport policies. This study aims to develop a Decision Support System (DSS) to assist countries in selecting transport policies and to demonstrate its applicability. The primary motivation of the research is to identify transport policies for Russia's Arctic region and to determine the best alternative policy based on expert evaluations. For this purpose, the IF-SIWEC-ARLON (Intuitionistic Fuzzy Sets - Simple Weight Calculation - Alternative Ranking Using Two-Step Logarithmic Normalization) hybrid method was developed as a DSS in this study. To implement this hybrid method, a decision model incorporating experts, criteria, and transport policies was first established. The contribution levels of experts to the decision-making process were calculated using IF sets. Next, the criteria weights were determined using the IF-SIWEC approach. Finally, the ranking of transport policies was carried out using the IF-ARLON method. An algorithm representing the application of this hybrid method was developed and applied to a case study focusing on Russia's transport policy selection process of Northern Sea Route (NSR) in the Arctic region. The results supported the successful application of the IF-SIWEC-ARLON hybrid method. Its robustness was tested through sensitivity analysis scenarios, while the consistency of the findings was verified via comparative analyses. The study concluded that the best transport policy for Russia's Arctic region is Improved regulatory control with strategic international partnerships, with the most influential criterion in the decision process identified as State interests, security, and sovereignty..
- MakaleAçık Erişim2025Scopus SJRQ2Inspiratory muscle training in natural bodybuilders: adaptations in diaphragm muscle thickness and maximal strength
Güler, Iskender; Yilmaz, Coskun; Soylu, Hakan Hueseyin; Birinci, Muersit Ceyhun; Arslan, Ayla; Ocak, Hakan; Çayir, Huseyin; Kavuran, Korhan; Saç, Ajlan; Uçar, Mine Akkus
Background: The effect of inspiratory muscle training on diaphragm muscle thickness (DT) and one repetition maximal (1RM) in professional natural bodybuilders is still unclear. The aim of the study was to investigate the effect of inspiratory muscle training on diaphragm muscle thickness and 1RM in professional natural bodybuilders. Methods: The study comprised a total of 22 athletes who participated in bodybuilding competitions. Each athlete had undergone a minimum of 5 years of training, with a minimum weekly commitment of 5 hours. Participants were randomly divided into two groups: inspiratory muscle training (IMT) and control (CON). The CON continued their normal training regime, while the IMT group also performed inspiratory muscle training with a 10% weekly increase by setting the resistance setting of the PowerBreathe (R) Classic device to 40% of the participant's maximum inspiratory pressure (MIP). Prior to and during the 4-week training period, 1RM bench press measurements and diaphragm muscle thickness measurements were obtained. Results: In the comparison of 1RM power values before and after training, it was determined that the IMT group (%: 11.20) had 6.3% more post-activation performance enhancement compared to the CON group (%: 4.9) (p < 0.001). In the study, it was determined that a higher level of significant post-activation performance enhancement was obtained in the IMT group compared to the CON group in the diaphragm muscle thickness inspiratory phase (DT ins) and ekspiratory phase (DT eks) parameters at 20.36% and 19.46%, respectively. Conclusion: In conclusion, we determined that the addition of progressive loading inspiratory muscle training to preparation programmes in natural bodybuilders will improve diaphragm muscle thickness, 1RM physical performance. In particular, it shows that the diaphragm muscle should be considered not only as a muscle that supports respiration, but also as a muscle that contributes to power generation by optimising intra-abdominal pressure.
- MakaleAçık Erişim2026Scopus SJRQ1YOLOv8 computer vision for automated offside detection in professional football validated through supervised learning
Abdel-Fattah, Abdul-Rahman; Belhaouari, Samir Brahim; Ceylan, Halil Ibrahim; Bayrakdaroglu, Serdar; Muntean, Raul Ioan; Dhahbi, Wissem; Dergaa, Ismail; Omri, Abdelfatteh El
Offside calls are integral to maintaining fairness and competitive integrity in football, yet current officiating processes are constrained by limitations in accuracy despite technological advancements. This investigation developed and validated an automated offside detection system using YOLOv8 object detection architecture to address documented limitations of Video Assistant Referee (VAR) systems in offside decision accuracy. Supervised learning validation employed 400 annotated instances from professional match footage. The YOLOv8 medium variant was configured for four-class detection, with a focus on extreme player positions, reducing computational complexity by approximately 70% relative to comprehensive player tracking while accepting accuracy trade-offs in marginal scenarios. The system was optimized for computational efficiency through highly accurate tracking of player positions. Data were partitioned into 40% (n = 160) for training and 60% (n = 240) for testing, with 5-fold cross-validation. The automated system achieved robust performance metrics across 240 test instances: overall accuracy of 83.0%, precision of 85.0%, recall of 87.0%, and F1-score of 86.0%. Confusion matrix analysis revealed true positives (n = 130), true negatives (n = 70), false positives (n = 22), and false negatives (n = 18). Individual case analysis demonstrated 80% agreement with ground truth classifications. System performance significantly exceeded the random classification baseline (p < 0.001). The strategic extreme player tracking approach achieved substantial computational efficiency while maintaining decision accuracy across diverse match scenarios. A YOLOv8-based offside detection system demonstrates proof-of-concept feasibility for decision-support applications in football officiating. Performance (83% accuracy, 95% CI: 79-87%) on 240 test instances remains below professional benchmarks (> 93%), with single-camera constraints and limited dataset size restricting generalizability to proof-of-concept validation rather than operational deployment.
- MakaleAçık Erişim2026Scopus SJRQ1Short-Term Inspiratory Muscle Training Enhances Functional and Metabolic Health in Older Adults
Konca, Erkan; Yilmaz, Coskun; Bayrakdaroglu, Serdar; Ceylan, Halil Ibrahim; Arslan, Ayla; Ocak, Hakan; Karakulak, Izzet; Sari, Rifat; Uzun, Recep Nur; Soylu, Hakan Huseyin
Background: Age-related declines in respiratory muscle strength and ventilatory efficiency can impair functional capacity and metabolic health in older adults. Inspiratory muscle training (IMT) has been proposed as a practical intervention to counteract these changes, yet its systemic effects remain unclear. This study aimed to examine the effects of short-term IMT on functional capacity, diaphragm thickness, and liver tissue characteristics in healthy elderly men. Methods: Thirty community-dwelling men aged 60-80 years were randomly assigned to an IMT or control group. The IMT group performed four weeks of breathing exercises using a POWERbreathe (R) device at 40% of maximal inspiratory pressure, with a weekly 10% increase in pressure. Pre- and post-intervention assessments included the six-minute walk test (6MWT), diaphragm thickness and liver density via computed tomography, and quality of life (QoL; SF-12). Results: Four weeks of inspiratory muscle training significantly improved diaphragm thickness (11.7%), fatty liver density (FLD) (+16.7%), and six-minute walk performance (+5.3%), with large time x group effects favoring the IMT group. While the physical quality of life showed modest, comparable improvements, mental health outcomes demonstrated a moderate, time-dependent improvement without a significant group-by-time interaction. Conclusions: Short-term IMT improved diaphragmatic function and functional capacity in older men and was associated with favorable changes in a liver-related biomarker; however, given that only a single liver-related metric was assessed, these findings should not be interpreted as evidence of overall improvements in liver health.
- MakaleAçık Erişim2023Scopus SJRQ1Determining the coronavirus awareness of the Turkish society and the anxiety stress levels
Aydin, Aydanur; Aktug, Cemile; Koçan, Sema; Erkaya, Reyhan; Yasak, Kubra; Cengiz, Burcu; Çalik, Kiymet Yesilcicek; Güler, Sevil; Erden, Sevilay; Karabulutlu, Ozlem
The aim of the study is to determine the awareness of the Turkish society in COVID-19, and determine the anxiety stress levels. Research two months after the start of the outbreak in Turkey has reached 2163 individuals completed the online platform. The Integrated Anxiety Stress Scale significantly changed according to age, gender, marital status and working status after the pandemic. According to the results of multiple binary logistic regression analysis, individuals aged 50 and over, female gender, being single and not working after the pandemic for anxiety; female gender, being married, and post-pandemic study were found to be risk factors for Covid awareness. It is recommended that epidemic awareness studies and information sharing on controlled healing measures are planned considering the anxiety levels.
- MakaleAçık Erişim2024Scopus SJRQ1Late pleistocene glacial history of Mount Karadag, SW Turkiye
Bayrakdar, Cihan; Çilgin, Zeynel; Saris, Faize; Yesilyurt, Serdar; Keserci, Ferhat; Büyükdeniz, Yusuf; Halis, Onur; Vockenhuber, Christof; Ivy-Ochs, Susan; Akçar, Naki
Glacial landforms in the southwestern part of the Anatolian Peninsula are found at lower elevations than the rest, suggesting that glaciers were present during the Late Pleistocene. Karadag, located west of the Western Taurus Mountains, provides evidence of the climatic conditions that facilitated this extensive glaciation. It is characterized by numerous peaks exceeding 2300 m above sea level (asl), with the highest peak reaching 2418 m, making it the region's largest glaciation area. This high mountain mass is composed mainly of limestone and dolomite. This study focuses on the glacial landforms in Karadag to reconstruct the Late Pleistocene glacial chronology and palaeoclimate of the Western Taurus Mountains. We employed detailed UAV photogrammetry, extensive fieldwork and mapping, surface exposure dating with cosmogenic 36Cl, meteorological measurements, palaeoglacier reconstruction, and palaeo-equilibrium line altitude (pELA) calculations. Karadag, a topographic barrier to humid air masses from the Mediterranean Sea, ranks as the second wettest area in the Western Taurus Mountains. At a meteorological station we installed in Karadag, an annual precipitation of 1700 mm or more was recorded, highlighting its significant precipitation. In Karadag, we have identified two glacial valleys with a maximum length of 4.5 km and six cirques. The glaciers reached their maximum extent around 22.4 f 2.8 ka during the Last Glacial Maximum (LGM), facilitated by the lowering of the pELA to 2090 m. During the LGM, the glaciers covered an area of approximately 3.5 km2 and reached a maximum thickness of about 140 m. Sample TRKR 10 at 2015 m probably belongs to the LGM period. Although a single sample does not conclude definitive conclusions, the presence of the moraine at its highest position indicates the maximum thickness of the glacier. Following the LGM, two more significant glacier advances occurred during the Lateglacial (15.5 f 2.7 ka) and the Younger Dryas (12.4 f 1.1 ka). During the late Pleistocene glaciations, and especially during the LGM, Karadag probably received more precipitation than today, leading to the formation of glaciers at relatively lower elevations than on the Anatolian Peninsula.
- MakaleYalnız künye2023Scopus SJRQ3The Distinguishing Factor in Soccer Players is Aerobic Performance, not the ACTN3 Gene
Zileli, Raif; Söyler, Mehmet; Diker, Gurkan; Özkamçi, Huseyin; Bayrakdaroglu, Serdar; Sever, Mehmet Onur; Can, Ibrahim; Ön, Sadi; Aslan, Beste Tacal; Ulucan, Korkut
The purpose of this study was to reveal the differences between ACTN3 genotype (RR, RX, XX) and aerobic performance [Yo-Yo IRT1 (m), VO2 max (ml/kg/min)] in professional and regional amateur league soccer players and to reveal which of these parameters was a distinctive factor in these athletes.71 professional soccer players (age: 23.66 +/- 4.11 years; body height: 1.79 +/- 6.99 m; body weight: 76.02 +/- 6.76 kg; body fat: 11.59 +/- 3.11 %) and 62 regional amateur soccer players (age: 23.63 +/- 3.77 years; body height: 1.81 +/- 5.77 m; body weight: 76.36 +/- 7.53 kg; body fat: 15.60 +/- 4.65 %) volunteered for the study. After DNA extraction from buccal epithelial cells via a commercial kit was performed for the genetic background of the athletes, Real-Time PCR was carried out for genotyping. Furthermore, Yo-Yo IRT1 test was performed to determine the aerobic performance of the soccer players. SPSS 23 (SPSS Inc., Chicago, IL, USA) package program was used for the statistical analysis of the data obtained in the tests. Shapiro-Wilk test for normality and Levene's test for homogeneity of variance were performed. Chi-Square, Independent Sample T Test and One Way ANOVA test were used in the analysis of the parameters. Statistical significance was set as p<0.05. In the study, there found no meaningful statistical significance in terms of the rs1815739 polymorphism in the ACTN3 gene between the groups (p>0.05); however, there was a statistical significance in favor of professional soccer players in terms of aerobic parameters (p<0.05). Consequently, it can be said that aerobic performance is the distinguishing factor, not the ACTN3 gene, in soccer players.
- MakaleYalnız künye2024Scopus SJRQ3Sprint and Anaerobic Power with the Soccer-Specific ACTN3 Gene: A Distintive Example
Söyler, Mehmet; Zileli, Raif; Özkamci, Huseyin; Diker, Gurkan; Sever, Mehmet Onur; Bayrakdaroglu, Serdar; Ön, Sadi; Can, Ibrahim; Ulucan, Korkut; Aslan, Beste Tacal
The aim of this study is twofold: (1) to identify differences in certain anaerobic parameters (10m sprint, 30m sprint, anaerobic power, and Illinois agility tests) between professional and amateur soccer players, and (2) to determine whether there is a difference in the ACTN3 gene polymorphism between professional and amateur soccer players. Ultimately, the goal is to reveal which parameters contribute to the differentiation in these two aspects. A total of 133 volunteer soccer players, including 71 professionals and 62 amateurs, participated in the research. DNA extraction from buccal epithelial cells was performed using a commercial kit to determine the genetic background of the athletes, and Real -Time PCR was conducted for genotyping. Statistical analysis of the findings obtained from the test results was performed using the SPSS 23 (SPSS Inc., Chicago, IL, USA) package program. The homogeneity of variance of the data was assessed using the Levene Test, and normal distribution analyses were conducted using the Shapiro -Wilk Test. Chi-square and Mann -Whitney U tests were employed for parameter analysis. The significance level was set at p<0.05. Evaluation of the data in our study revealed no statistically significant difference in ACTN3 rs1815739 gene polymorphism between the groups (p>0.05). However, there is a statistically significant difference in anaerobic parameters (10m sprint, 30m sprint, and anaerobic power) except for the Illinois test (p<0.05). In conclusion, our study found that gene polymorphism is not a differentiating factor between professional and amateur soccer players, but speed (10m and 30m) and anaerobic power parameters are differentiating factors.
- MakaleAçık Erişim2025Scopus SJRQ1Judo exercises increase emotional expression, self-control, and psychological resilience
Köroglu, Mihrac; Yilmaz, Coskun; Tan, Cetin; Çelikel, Baha Engin; Budak, Cemalettin; Kavuran, Korhan; Susuz, Yunus Emre; Barut, Yasar; Ceylan, Tulay; Soyer, Fikret
Background: The extant research on judo sports has principally concentrated on the physiological effects of training. Conversely, there has been limited attention paid to studies on psychological resilience, self-control, and emotional expression levels. The present study examined the effects of Judo exercises on psychological resilience, self-control, and emotional expression levels in healthy male subjects. Methods: The present study comprised 50 healthy, sedentary male subjects. The subjects were randomly divided into two groups: one group participated in judo training (JT) and the other group served as the control group (CON). The sample sizes for the JT and CON groups were both 25. The JT group underwent judo training, while the CON group maintained their usual lifestyle. The Brief Psychological Resilience Scale, the Multidimensional Brief Self-Control Scale, and the Berkeley Emotion Expression Scale were administered prior to and following the 6-week training period. Results: The study demonstrated that a 6-week judo training regimen exerted a significant effect on the psychological resilience score (e.s. = 1.047, p < 0.001), while no such effect was observed in the Control group (e.s. = 0.0091, p = 0.751). In the context of self-control levels, an effect was observed on the Initiation sub-dimension (e.s. = 1, 739, p < 0.001), yet no effect was found on the Inhibition dimension (e.s. = 0.052, p = 0.892). In the control group, a significant decrease was identified in the Initiation sub-dimension (e.s. = 0, 785, p = 0.001) and Inhibition sub-dimension (e.s. = 1, 861, p < 0.001). The findings indicate that impulse power (e.s. = 0.395) and concealment (e.s. = 0.428) exerted a negligible influence on the emotional expression sub-dimensions. Conversely, psychological resilience (e.s. = 0.886) demonstrated a substantial impact. Conclusions: The judo exercises demonstrated a favorable impact on psychological resilience, self-control, and emotional expression levels in healthy male subjects. The findings of this study may offer significant insights into the impact of judo exercises on psychological resilience, self-control, and emotion expression levels. These findings could serve as a guide for the development of future interventions and program design in the domain of sport psychology.
- MakaleAçık Erişim2025Scopus SJRQ3Investigation of the relationship between apelin hormone response and some physiological parameters in enzootic bovine leukosis virus infected cattle
Sait, A.; Bayraktar, B.; Korkmaz, S.; Genç, M.; Bayraktar, S.; Kotan, G. C.; Aydemir, S.; Takma, C.; Bülbül, A. S.; Aksakal, V
Apelin is a hormone with lymphangiogenesis potential, associated with tumor growth and lymph node metastasis, and is reported to stimulate tumor vascularization. This study aimed to investigate the response of the apelin hormone in cattle with and without Enzootic Bovine Leukosis (EBL) infection, based on physiological parameters such as breed, age, and body condition score (BCS). A total of 120 Simmental and Montafon cattle of varying ages (<2, 2-8, and >8) and BCS categories (<2, 3-3.5, and >= 4) were included in the study. Serum apelin hormone levels were measured using the ELISA technique in blood samples collected from the neck vein ( Vena jugularis) of the animals. The analysis of mean serum apelin (ng/mL) values revealed that, among EBL-positive cattle, the highest value was 2.77 ng/mL in Simmental cattle aged 2-8 years with a BCS of 3-3.5, while a value of 2.69 ng/mL was observed in Montafon cattle aged >8 years with a BCS of 3-3.5. For EBL-negative cattle, the highest mean serum apelin value was 2.24 ng/mL, recorded in Simmental cattle aged 2-8 years with a BCS of 3-3.5, whereas it was 1.45 ng/mL in Montafon cattle aged >8 years with the same BCS. In conclusion, this study demonstrated for the first time the effect of apelin hormone levels in cattle with or without EBL, depending on physiological parameters such as age, breed, and BCS. It is suggested that the apelin hormone, which is involved in neoplastic lymphocyte cell infiltration in the lymphoreticular tissues of cattle, and plays a role in regulating tumor growth in EBL, a malignant tumor disease, may contribute to eradication programs. Moreover, the evaluated parameters may prove valuable for disease prevention and control strategies.
- MakaleYayıncıda açık erişim2026Scopus SJRQ1The mediating role of mental fatigue awareness in the relationship between perceived stress and psychological well-being among combat athletes
Yilmaz, Taner; Öz, Faik; Gül, Oguzhan; Dal, Suzan; Kara, Tayfun; Akkoç, Orkun; Küçük, Hamza; Fort, Patricia Roxana; Çitozi, Robert; Kadi, Mustafa Nurullah
Background Combat athletes face unique psychological demands, and stress may influence both their cognitive experiences and psychological well-being. This study aimed to examine the mediating role of mental fatigue awareness in the relationship between perceived stress and psychological well-being among combat athletes, thereby contributing to a clearer understanding of a potential cognitive mechanism linking stress to well-being in this population.Methods A total of 303 combat athletes voluntarily participated. Participants completed the Perceived Stress Scale, Mental Fatigue Awareness Scale, and Psychological Well-being Scale. Statistical analyses assessed the direct effects of perceived stress on psychological well-being, the effect of stress on mental fatigue awareness, and the potential mediating role of mental fatigue awareness.Results Perceived stress significantly increased mental fatigue awareness (b = 0.732, SE = 0.064, beta = 0.549, p = 0.001) and directly decreased psychological well-being (b = - 0.488, SE = 0.166, beta = - 0.191, p = 0.004). Mental fatigue awareness negatively affected psychological well-being (b = - 0.374, SE = 0.124, beta = - 0.195, p = 0.003) and partially mediated the relationship between stress and well-being (indirect effect: b = - 0.274, SE = 0.115, beta = - 0.107, p = 0.003; 95% CI = - 0.504 to - 0.049).Conclusion Perceived stress was associated with psychological well-being both directly and indirectly through increased mental fatigue awareness. These findings suggest that mental fatigue awareness may represent a relevant cognitive pathway linking stress perceptions to well-being. Accordingly, stress management and strategies aimed at regulating mental fatigue may be considered as potentially beneficial components in efforts to support psychological well-being among combat athletes.
- MakaleYalnız künye2026Scopus SJRQ1Chemical characterization and bioactivity assessment of Erodium cedrorum subsp. salmoneum extracts supported by in silico analysis
Yagi, Sakina; Zengin, Gokhan; Zoltan, Cziaky; Jeko, Josef; Ivashchanka, Yahor; Turecka, Katarzyna; Halasa, Rafal; Gucwa, Magdalena; Kochan-Jamrozy, Kinga; Stefanowicz-Hajduk, Justyna
The growing interest in natural products, particularly as food additives and pharmaceutical raw materials, is making research into discovering new sources especially important. Erodium cedrorum subsp. salmoneum (family Geraniaceae) is used traditionally to cure many ailments like diabetes and gastro-intestinal diseases. Within this background, the current study was designed to investigate, for the first time, the chemical composition, antioxidant and enzyme inhibitory poroperties of different extracts from the aerial parts and roots of E. cedrorum. Results revealed that the aqueous extract of the aerial parts accumulated the highest total phenolic (85.35 mg GAE/g) and flavonoids (28.65 mg RE/g) contents. A total of 61 and 45 compounds, belonging mainly to phenolic acids and flavonoids, were tentatively identified in the aerial parts and roots extracts respectively. The aqueous extract from the aerial parts exerted the highest antiradical, ions reducing and chelation properties. The EtOH and 70% EtOH extracts of the two organs recorded the best anti-acetylcholinesterase activity (2.18 -2.41 mg GALAE/g; p >= 0.05) while those of the roots recorded respectively the best anti-butyrylcholinesterase and antityrosinase activities. The most potent antibacterial activity was exhibited by the 70% EtOH extracts from aerial parts and the pure EtOH extracts from roots. In contrast, ethyl acetate extracts from both plant parts showed only marginal activity. Among the tested strains, the highest susceptibility was observed against C. sporogenes ATCC 19404, C. bifermentans ATCC 638, S. aureus ATCC 6538, S. aureus ATCC 43300 (MRSA), C. diphtheriae PCM 506, and H. pylori ATCC 43504. The extracts were also examined for their anti-cancer potential on the HeLa, AGS and SKOV-3 cell lines, as well as a non-cancerous cell line. The ethyl acetate extract of the roots exhibited the most potent anti-cancer activity, with the lowest IC50 values. In addition, selected top-ranked complexes against AChE, alpha-amylase, representative bacterial and oncogenic targets were further evaluated by molecular docking and 100 ns molecular dynamics (MD) simulations, indicating overall conformational stability and persistent binding. In conclusion, these results position E. cedrorum as a valuable natural source of antioxidant and enzyme-inhibitory agents, meriting further exploration for drug development purposes.
- MakaleAçık Erişim2025Scopus SJRQ3ACTN3, IL-6 AND PPARA GENE POLYMORPHISMS AND ANAEROBIC PERFORMANCE IN VOLLEYBALL PLAYERS
Ön, Sadi; Can, Ibrahim; Bayrakdaroglu, Serdar; Sever, Mehmet Onur; Diker, Gurkan; Özkamçi, Huseyin; Zileli, Raif; Söyler, Mehmet; Yilmaz, Ozlem Ozge; Polat, Tolga
The aim of this study is to determine the relationship between ACTN3 rs1815739, IL-6 rs1800795, and PPARA rs4253778 gene polymorphisms and anaerobic test parameters among volleyball players. A total of 22 volleyball players voluntarily participated in the study. DNA isolation from buccal epithelial cell samples were performed using a PureLink DNA isolation kit, following the manufacturer's instructions. The genotyping of ACTN3 rs1815739, IL-6 rs1800795, and PPARA rs4253778 gene polymorphisms were determined using the real-time polymerase chain reaction technique. Statistical analysis of the test results was performed using the SPSS 23 software package. Homogeneity of variance was assessed with the Levene test, and normal distribution was evaluated using the Shapiro-Wilk test. The One-Way ANOVA test was applied for the analysis of all parameters, and significance was set at p < 0.05. When the data were evaluated, no statistically significant differences were observed between PPARA rs4253778 and ACTN3 rs1815739 gene polymorphisms and anaerobic performance parameters (p>0.05). Statistically significant differences were observed between the IL-6 rs1800795 gene polymorphism and anaerobic performance parameters of back strength (p> 0.05). In conclusion, in volleyball, PPARA rs4253778 andACTN3 rs1815739 gene polymorphisms did not cause differentiation in anaerobic performance parameters. However, IL-6 gene polymorphism caused differentiation only in the back strength parameter. Additionally, the good performance of athletes with different prevalent level of genotypes in the studied performance criteria does not fully reveal which performance outcomes are influenced by the gene or genotype distributions. It is understood that further studies are needed to better determine the gene-performance relationship.
- MakaleYalnız künye2014Scopus SJRQ2Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey
Iraz, Meryem; Duzgun, Azer Ozad; Cicek, Aysegul Copur; Bonnin, Remy A.; Ceylan, Aysenur; Saral, Aysegul; Nordmann, Patrice; Sandalli, Cemal
Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), extensively-drug resistant (n = 5), or pan-drug resistant (n = I). PCR and DNA sequence analysis revealed that 1 strain possessed the bla(GES-5) and another carried a novel bla(VIM) variant, named VIM-38. This new gene exhibited 1 amino acid substitution (Ala265Val) in comparison to its closest variant, VIM-5. Both VIM encoding genes were clones and demonstrated similar susceptibility profile when expressed in identical background. The presence of VIM-38 increases the diversity of carbapenemases in Turkey. (C) 2014 Elsevier Inc. All rights reserved.
- MakaleAçık Erişim2025Scopus SJRQ1Exploring how cognitive-behavioral physical activity links ruminative thinking and mental wellbeing in sports high school adolescents
Derelioglu, Mehmet; Vural, Mustafa; Çimen, Erkan; Saki, Unal; Yagiz Saracoglu, Yusuf; Karatas, Baykal; Saç, Ajlan; Yamaner, Emre; Halmatov, Medera; Yilmaz, Coskun
Introduction: This study examined the associations among ruminative thinking style (RTS), subjective wellbeing (SWB), and cognitive-behavioral physical activity (CBPA) in a sample of 1,326 adolescents (aged 14-18) from sports high schools. Method: Using validated self-report measures, data were analyzed through bootstrapped mediation models. Results: RTS was negatively associated with SWB (beta = -0.1792, p < 0.001), while CBPA showed a partial mediating effect in this relationship (indirect beta = 0.0779, p < 0.001). Discussion: These results suggest that cognitive-behavioral orientations toward physical activity may buffer the negative impact of rumination on wellbeing. Consistent with cognitive-behavioral therapy (CBT) principles, CBPA could provide adolescents with self-regulatory strategies that support mental health. However, the cross-sectional and self-report design, as well as the focus on sports high school students, limit causal inference and generalizability. Future longitudinal and cross-cultural studies are needed to confirm these findings. Overall, the study provides preliminary evidence that CBPA-informed approaches may hold promise for promoting adolescents' mental wellbeing.
- MakaleAçık Erişim2026Scopus SJRQ1Effects of wrestling training on psychological well-being, anxiety, and resilience in adolescent boys
Özkan, Ridvan; Yilmaz, Coskun; Uzun, Recep Nur; Bayrakdaroglu, Serdar; Akar, Ozge Orhan; Öz, Faik; Çiçekli, Atif; Çiçekli, Aylin; Dal, Suzan; Ursu, Vasile Emil
Background Wrestling is a physically and mentally demanding combat sport that requires discipline, focus, and emotional control. Although its physiological effects are well documented, its psychological benefits in adolescents remain underexplored. This study aimed to examine whether a short-term, non-competitive wrestling program could enhance psychological well-being, reduce sport anxiety, and strengthen resilience in adolescent boys. Methods Thirty sedentary male adolescents (aged 12-15 years) were randomly assigned to a wrestling training group (n = 15) or a control group (n = 15). The intervention consisted of six weeks of supervised wrestling sessions performed three times per week. Psychological well-being (WHO-5), sport anxiety (SAS-2), and resilience (BPRS) were assessed before and after the intervention using the validated Turkish versions of the scales. Two-way repeated-measures ANOVA was used to analyze group & times; time interactions. Results Participants in the wrestling group demonstrated significant improvements in well-being (p < 0.001) and resilience (p < 0.001), alongside marked reductions in total sport anxiety and its subdimensions (p < 0.001), compared with the control group. All effects were large (eta p & sup2; = 0.52-0.94). Conclusion A structured six-week wrestling program produced meaningful psychological benefits in adolescent boys. Regular participation in non-competitive wrestling may serve as an effective approach to promote well-being, emotional stability, and adaptive coping skills during early adolescence, supporting the preventive and developmental role of combat sports in youth mental health.
- MakaleYalnız künye2026Scopus SJRQ1Building Resilience in Global Tourism: A Theoretical and Empirical Analysis of Indicators for Sustainable Development
Erol, Ismail; Dogru, Tarik; Oztel, Ahmet; Bilgihan, Anil; Peker, Iskender; Neuhofer, Irem Onder
The primary perspective of this study is the global tourism industry (GTI) as an interconnected supply chain network, encompassing both tourism firms (e.g., hotels, airlines, and operators) and destinations (e.g., local communities and ecosystems). This industry-level focus allows for analyzing resilience indicators that bridge firm-specific capabilities with destination-wide vulnerabilities, rather than isolating one over the other. Using a mixed-method approach, this research conceptualizes resilience through various management theories. First, it identifies critical resilience indicators across institutional, societal, economic, and ecological dimensions. Second, these indicators are analyzed with a novel Spherical Fuzzy Interpretive Structural Modeling and Cross-Impact Matrix Multiplication Applied to Classification framework, utilizing expert opinions to uncover complex interdependencies among indicators. The findings of this study highlight that effective government policies, robust incentive mechanisms, advanced digital infrastructure, dynamic capabilities, and ecologically sustainable tourism practices are key drivers of resilience. However, socioeconomic impacts, tourist satisfaction, and price competitiveness emerge as highly dependent outcomes influenced by these drivers. This study also introduces the Adaptive Global-Local Interaction Theory, a new framework that integrates global influences with local realities to enhance tourism resilience. By offering a comprehensive framework and practical guidelines, this research equips policymakers and stakeholders with actionable strategies to bolster the industry's capacity to anticipate, adapt to, and recover from crises, promoting sustainable development amidst volatile global conditions.
- MakaleAçık Erişim2021Scopus SJRQ1LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kinkor (Ferulago stellata)
Kiziltas, Hatice; Bingol, Zeynebe; Gören, Ahmet Ceyhan; Kose, Leyla Polat; Durmaz, Lokman; Topal, Fevzi; Alwasel, Saleh H.; Gulcin, Ilhami
Kinkor (Ferulago stellata) is Turkish medicinal plant species and used in folk medicine against some diseases. As far as we know, the data are not available on the biological activities and chemical composition of this medicinal plant. In this study, the phytochemical composition; some metabolic enzyme inhibition; and antidiabetic, anticholinergic, and antioxidant activities of this plant were assessed. In order to evaluate the antioxidant activity of evaporated ethanolic extract (EEFS) and lyophilized water extract (WEFS) of kinkor (Ferulago stellata), some putative antioxidant methods such as DPPHGreek ano teleia scavenging activity, ABTS(center dot+) scavenging activity, ferric ions (Fe3+) reduction method, cupric ions (Cu2+) reducing capacity, and ferrous ions (Fe2+)-binding activities were separately performed. Furthermore, ascorbic acid, BHT, and alpha-tocopherol were used as the standard compounds. Additionally, the main phenolic compounds that are responsible for antioxidant abilities of ethanol and water extracts of kinkor (Ferulago stellata) were determined by liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Ethanol and water extracts of kinkor (Ferulago stellata) demonstrated effective antioxidant abilities when compared to standards. Moreover, ethanol extract of kinkor (Ferulago stellata) demonstrated IC50 values of 1.772 mu g/mL against acetylcholinesterase (AChE), 33.56 +/- 2.96 mu g/mL against alpha-glycosidase, and 0.639 mu g/mL against alpha-amylase enzyme respectively.
