Yayınlar
Koleksiyondaki öğeler
- MakaleYalnız künye2026Scopus SJRQ1Efficacy and safety of doxorubicin-ifosfamide versus gemcitabine-docetaxel as first-line therapy in advanced nonuterine leiomyosarcoma: A multicenter real-world study
Tunbekici, Salih; Sahin, Gokhan; Yuksel, Haydar Cagatay; Acar, Caner; Akin, Imge; Aslanhan, Hasan; Isci, Mert; Kabaoglu, Ceren; Bal, Hamit; Sakin, Abdullah
Nonuterine leiomyosarcoma (NU-LMS) is a rare and biologically distinct subtype of soft tissue sarcoma (STS) with clinical behavior differing from that of uterine leiomyosarcoma. In advanced or metastatic STS, immunotherapy has demonstrated only modest activity, and chemotherapy remains the cornerstone of treatment. However, there is a persistent unmet need for more effective and better-tolerated options in this population. This multicenter, retrospective study included 150 patients with histologically confirmed metastatic NU-LMS who received first-line doxorubicin-ifosfamide (AI) or gemcitabine-docetaxel (GD) at 26 oncology centers in Turkey between 2010 and 2024. The primary endpoint was overall survival (OS). Survival was analyzed using Kaplan-Meier estimates and Cox proportional hazards models. Of 150 patients, 79 received AI and 71 received GD. Median OS for the entire cohort was 21.0 months. Median OS was 22.0 months with AI and 19.1 months with GD (p = .18), median progression-free survival was 7.3 versus 6.1 months (p = .66), and overall response rate was 25.3% versus 29.6% (p = .58), indicating no statistically significant differences in efficacy between the two regimens. Hematologic toxicities were less frequent with GD. AI and GD demonstrated comparable efficacy as first-line regimens for advanced or metastatic NU-LMS, with fewer hematologic toxicities observed for GD. Tumor location may have prognostic implications. These findings support individualized treatment selection and highlight the need for prospective studies in this rare and understudied sarcoma subtype, while the recent LMS-04 trial underscores the importance of future comparisons with doxorubicin-trabectedin to further refine first-line strategies in LMS.
- MakaleYalnız künye2026Scopus SJRQ3New national and regional bryophyte records, 86
Wilbraham, J.; Abdirasulov, F.; Aguirre, J.; Alatas, M.; Alba, W. R. Alvaro; Ergenekon, Z. Aslan; Raj, K. Aswathy; Ayhan, E.; Batan, N.; Bednarek-Ochyra, H.
- MakaleAçık Erişim2026Scopus SJRQ3Preferences for mechanical ventilation modes among intensivists in Türkiye: a nationwide point-prevalence study
Yildirim, Suleyman; Kilinçözgün, Nurhayat; Alpdogan, Ozcan; Uçar, Huseyin; Taskiran, Imren; Ata, Adnan; Özcan, Ozhan; Öncü, Kivanc; Acarbay, Saba Mukaddes; Güner, Temel
Background/aim: Invasive mechanical ventilation (IMV) is a fundamental intervention for patients with respiratory failure in intensive care units (ICUs). This nationwide, multicenter point-prevalence study aimed to describe current mechanical ventilation mode preferences (conventional, adaptive, and biphasic) in Turkish ICUs and to report associated clinical outcomes descriptively, without assessing causal relationships. Materials and methods: A nationwide, multicenter point-prevalence study was conducted on 17 April 2024 and included adult patients (>= 18 years) who had been receiving IMV for more than 24 h. Data on patient demographics, ventilation mode distribution, ventilatory parameters, and descriptive clinical outcomes on day 28 (weaning status, tracheostomy, and mortality) were recorded without comparative outcome analysis. Results: A total of 426 patients were included. Conventional modes were used in 84.5% of patients, adaptive modes in 10.6%, and biphasic modes in 4.9%. Synchronized intermittent mandatory ventilation (SIMV) was the most commonly used conventional mode. The primary indication for IMV was acute respiratory failure (61%), with pneumonia being the leading cause. Among the 350 orotracheally intubated patients, 25.6% were in the weaning phase on the study day. A total of 59 (16.9%) patients were extubated, 150 (42.9%) underwent tracheostomy, and 64 (18.2%) remained intubated on day 28. Overall, 185 (43.4%) patients died during their ICU stay, 152 (35.7%) remained in the ICU, and 89 (20.9%) were successfully discharged from the ICU. Conclusion: Conventional ventilation modes, particularly SIMV, were more commonly used in Turkish intensive care units (ICUs), whereas adaptive modes were less frequently applied. These patterns may reflect factors such as clinician familiarity, institutional practices, and equipment availability rather than definitive preferences. Although the impact of ventilation modes on clinical outcomes was not comparatively evaluated in this study, the choice of ventilation mode may still influence patient outcomes. Therefore, further prospective and comparative studies are warranted to better elucidate this relationship.
- MakaleAçık Erişim2025Scopus SJRQ3Efficacy of Second-Line Treatments After Atezolizumab and Bevacizumab in Advanced Hepatocellular Carcinoma and Related Prognostic Factors: A Multicenter Study by the Turkish Oncology Group (TOG)
Majidova, Nargiz; Yaslikaya, Sendag; Mildanoglu, Maral Martin; Coskun, Alper; Uzundal, Duygu Ercan; Sahin, Taha Koray; Akyildiz, Arif; Akbas, Sinem; Camanli, Ufuk; Sahin, Elif
Background/Aims: The treatment of hepatocellular carcinoma (HCC), which accounts for 90% of all liver cancers, is highly varied. The use of second-line treatments following progression on first-line atezolizumab and bevacizumab (Atez/Bev) for advanced HCC remains controversial. The aim of this study was to analyze the real-world clinical results of second-line treatments in progression after Atez/Bev and to determine the factors affecting prognosis. Materials and Methods: Fifty-eight patients treated with second-line sorafenib, regorafenib, and cabozantinib for progression after first-line Atez/Bev for advanced/metastatic HCC from 20 centers in T & uuml;rkiye between October 2020 and June 2024 were retrospectively analyzed. Responses were evaluated by Response criteria, specifically Response Evaluation Criteria in Solid Tumors (RECIST v1.1) criteria. Median overall survival (OS) and progression-free survival (PFS) were computed with the Kaplan-Meier method. The Cox regression model was utilized to analyze multivariate analyses. Results: About 82.8% of the patients were male and the median age of the whole group was 62 (range, 18-78) years. All patients progressed after first-line Atez/Bev and were given second-line treatment. The most commonly used second-line treatment option was sorafenib (70.7%), followed by regorafenib (12.1%) and cabozantinib (10.3%). Both median PFS (4.1 months) and median OS (7.8 months) were longer in patients treated with sorafenib compared to other treatments. In univariate analyses, Child-Pugh score B, high alpha-fetoprotein (AFP) levels (>200 ng/mL), extrahepatic spread, and Prognostic Nutritional Index (PNI) < 47.6 substantially raised the risk of overall mortality. Multivariate analysis showed that extrahepatic spread (HR (Hazard ratio): 0.41, P = .012), PNI level (HR: 0.24, P = .005), and AFP level (HR:1.97, P = .049) were independent predictors of OS. Conclusion: Although second-line therapies after Atez/Bev show different degrees of efficacy, survival rates are consistent with the literature. Extrahepatic spread, AFP level, and PNI level are the main prognostic factors. In light of this information, personalized treatment strategies may improve outcomes for this challenging patient group.
AtıfWoS1İncele - MakaleAçık Erişim2025Scopus SJRQ1Regorafenib Treatment for Recurrent Glioblastoma Beyond Bevacizumab-Based Therapy: A Large, Multicenter, Real-Life Study
Tünbekici, Salih; Yuksel, Haydar cagatay; Acar, Caner; Sahin, Goekhan; Orman, Seval; Majidova, Nargiz; Coskun, Alper; Seyyar, Mustafa; Dilek, Mehmet siddik; Kara, Mahmut
Background/Objectives: In the REGOMA trial, regorafenib demonstrated an overall survival advantage over lomustine, and it has become a recommended treatment for recurrent glioblastoma in guidelines. This study aimed to evaluate the effectiveness and safety of regorafenib as a third-line treatment for patients with recurrent glioblastoma who progressed while taking bevacizumab-based therapy. Methods: This retrospective, multicenter study in Turkey included 65 patients treated between 2021 and 2023 across 19 oncology centers. The main inclusion criteria were histologically confirmed isocitrate dehydrogenase (IDH)-wildtype glioblastoma, progression after second-line bevacizumab-based treatment, and an Eastern Cooperative Oncology Group (ECOG) performance status score of <= 2. Patients received regorafenib 160 mg once daily for the first 3 weeks of each 4-week cycle. Results: The median age of the patients was 53 years (18-67 years), with a median progression-free survival of 2.5 months (95% Confidence Interval: 2.23-2.75) and a median overall survival of 4.1 months (95% CI: 3.52-4.68). The median overall survival was improved in patients who received subsequent therapy after regorafenib treatment compared with those who did not (p = 0.022). Progression-free survival was longer in patients with ECOG 0-1 than in those with ECOG 2 (p = 0.042). The safety profile was consistent with that of the REGOMA trial, with no drug-related deaths observed. Conclusions: Regorafenib shows good efficacy and safety as a third-line treatment for recurrent glioblastoma after bevacizumab-based therapy. This study supports the use of regorafenib and emphasizes the need for further randomized studies to validate its role and optimize treatment strategies.
AtıfWoS6OpenAlex11İncele - MakaleAçık Erişim2023Scopus SJRQ3Vaccination status of COVID-19 patients followed up in the ICU in a country with heterologous vaccination policy: A multicenter national study in Turkey
Yildirim, Suleyman; Erkoyun, Erdem; Alpdog, Ozcan; Yilmaz, Huseyin Oguz; Yilmaz, Baris; Dönmez, Gul Erdal; Saritas, Aykut; Gökmen, Necati; Ergan, Begum; Bayrak, Vecihe
Objective: Vaccination against severe acute respiratory syndrome coronavirus-2 (SARS-2) prevents the development of serious diseases has been shown in many studies. However, the effect of vaccination on outcomes in COVID-19 patients requiring intensive care is not clear.Methods: This is a retrospective multicenter study conducted in 17 intensive care unit (ICU) in Turkey between January 1, 2021, and December 31, 2021. Patients aged 18 years and older who were diagnosed with COVID-19 and followed in ICU were included in the study. Patients who have never been vaccinated and patients who have been vaccinated with a single dose were considered unvaccinated. Logistic regression models were fit for the two outcomes (28-day mortality and in-hospital mortality).Results: A total of 2968 patients were included final analysis. The most of patients followed in the ICU during the study period were unvaccinated (58.5%). Vaccinated patients were older, had higher Charlson comorbidity index (CCI), and had higher APACHE-2 scores than unvaccinated patients. Risk for 28-day mortality and in-hospital mortality was similar in across the year both vaccinated and unvaccinated patients. However, risk for in-hospital mortality and 28-day mortality was higher in the unvaccinated patients in quarter 4 adjusted for gender and CCI (OR: 1.45, 95% CI: 1.06-1.99 and OR: 1.42, 95% CI: 1.03-1.96, respectively) compared to the vaccinated group.Conclusion: Despite effective vaccination, fully vaccinated patients may be admitted to ICU because of disease severity. Unvaccinated patients were younger and had fewer comorbid conditions. Unvaccinated patients have an increased risk of 28-day mortality when adjusted for gender and CCI.
AtıfWoS2OpenAlex3İncele - MakaleAçık Erişim2026Scopus SJRQ1Ethical Principles and Frameworks in Dementia Care: A Scoping Review
Serrat, Rodrigo; Lauridsen, Sigurd; Bobrowicz-Campos, Elzbieta; Brandao, Tania; Brites, Rute; Cannella, Valentina; Celdrán, Montserrat; Chacur-Kiss, Karima; Cin, Aynur; Fabà, Josep
Providing ethical care for people living with dementia is essential for safeguarding their rights, dignity, and well-being. However, ethical decision-making in dementia care is complex, often involving tensions between competing moral claims such as autonomy, beneficence, nonmaleficence, justice, and non-discrimination. This scoping review aimed to map and describe the ethical principles, related normative considerations, and ethical frameworks discussed in the scientific literature on dementia care, and to identify how these have been conceptualized. Following the methodological guidance of Arksey and O'Malley (2005), Levac et al. (2010), and Peters et al. (2021, 2022), a comprehensive search across five databases (Web of Science, Scopus, CINAHL, Medline/PubMed, and PsycInfo) identified peer-reviewed papers published in English. In total, 388 papers published between 1981 and 2024 were included. The results revealed a wide range of ethical principles and related normative considerations frequently cited in the literature, although they were typically discussed in an isolated way without reference to other principles or broader ethical frameworks. In contrast, ethical frameworks were mentioned far less often, and when they were, they mostly reflected traditional approaches such as principlism. Four gaps were identified: the plurality of ethical frameworks and limited conceptual integration underpinning dementia care research and practice; insufficient attention to ethnic and socioeconomic diversity among people living with dementia; limited consideration of diverse care settings and geographical regions; and the limited inclusion of people living with dementia themselves in the studies reviewed. These findings underscore the need for conceptually integrative, inclusive, and context-sensitive approaches to dementia care ethics that can better inform both ethical reflection and care practices.
AtıfWoS1İncele - DüzeltmeAçık Erişim2026Scopus SJRQ1Ethical Principles and Frameworks in Dementia Care: A Scoping Review (vol 19, 29, 2026)
Serrat, Rodrigo; Lauridsen, Sigurd; Bobrowicz-Campos, Elzbieta; Brandao, Tania; Brites, Rute; Cannella, Valentina; Celdrán, Montserrat; Chacur-Kiss, Karima; Cin, Aynur; Faba, Josep
Unfortunately, this article was published online with errors—the blinded names were not replaced. The corrected sentence is shown below. FROM: Step 2: Identifying Relevant Studies With the support of BLINDED FOR REVIEW, a professional librarian at the University of BLINDED FOR REVIEW, we developed and refined our search strategy through an iterative process involving the selection of both keywords and databases. TO: Step 2: Identifying Relevant Studies With the support of Joan Pons-Vila, a professional librarian at the University of Barcelona, we developed and refined our search strategy through an iterative process involving the selection of both keywords and databases.
- MakaleAçık Erişim2020Scopus SJRQ1Forest Biodiversity, Carbon Sequestration, and Wood Production: Modeling Synergies and Trade-Offs for Ten Forest Landscapes Across Europe
Biber, Peter; Felton, Adam; Nieuwenhuis, Maarten; Lindbladh, Matts; Black, Kevin; Bahyl, Jan; Bingöl, Ozkan; Borges, Jose G.; Botequim, Brigite; Brukas, Vilis
Europe's forests provide vital habitat for biodiversity and essential ecosystem services whose provision must be sustained or enhanced over the coming century. However, the potential to secure or increase forest ecosystem services, while securing the habitat requirements of taxa remains unclear, especially within the context of uncertain climate and socio-economic developments. To tease out the associated trade-offs and synergies, we used 10 case study landscapes within nine countries throughout Europe. Starting with the current status of the forests in the case study landscapes, we simulated forest development 100 years into the future. Simulations were embedded in three combined climate and socio-economic frame scenarios based on global and European policies which varied in their climate change mitigation efficiency. Scenarios were translated into country specific projections of climate variables, and resultant demands for wood products. Forest management regimes were projected to vary in response to these scenarios at local scales. The specific combinations of alternative forest management practices were based on parallel research and input from local forest stakeholders. For each case study, a specific forest growth simulator was used. In general, the climate scenarios applied did not cause fundamentally different ecosystem service outputs at the case study level. Our results revealed almost no reduction in outcomes for biodiversity indicators with an increase in wood production, and in some cases synergistic results occurred when diversity was actively promoted as part of the management concept. Net carbon uptake was not strongly correlated with biodiversity, indicating that biodiversity-friendly forest management doesn't need to curtail carbon sequestration. Notably, we obtained heterogeneous results for the relation between sustainable wood production and net carbon uptake. Most scenarios resulted in a more or less reduced net carbon uptake over the long term, often due to stand age class distribution shifts. Levels of sustainable wood production varied widely during the simulation period, from significant increases (Sweden, Lithuania) to minor changes (Slovakia, Turkey) and slight decreases (Ireland, Netherlands). We place our results within the larger context of European forest policy and the challenges of simulating and contrasting forest biodiversity and the ecosystem services that societies depend on.
AtıfScopus75WoS67OpenAlex76İncele - Derleme MakaleAçık Erişim2016Scopus SJRQ1Higher PUFA and n-3 PUFA, conjugated linoleic acid, α-tocopherol and iron, but lower iodine and selenium concentrations in organic milk: a systematic literature review and meta- and redundancy analyses
Srednicka-Tober, Dominika; Baranski, Marcin; Seal, Chris J.; Sanderson, Roy; Benbrook, Charles; Steinshamn, Havard; Gromadzka-Ostrowska, Joanna; Rembialkowska, Ewa; Skwarlo-Sonta, Krystyna; Eyre, Mick
Demand for organic milk is partially driven by consumer perceptions that it is more nutritious. However, there is still considerable uncertainty over whether the use of organic production standards affects milk quality. Here we report results of meta-analyses based on 170 published studies comparing the nutrient content of organic and conventional bovine milk. There were no significant differences in total SFA and MUFA concentrations between organic and conventional milk. However, concentrations of total PUFA and n-3 PUFA were significantly higher in organic milk, by an estimated 7 (95% CI -1, 15)% and 56 (95% CI 38, 74) %, respectively. Concentrations of alpha-linolenic acid (ALA), very long-chain n-3 fatty acids (EPA + DPA + DHA) and conjugated linoleic acid were also significantly higher in organic milk, by an 69 (95% CI 53, 84) %, 57 (95% CI 27, 87)% and 41 ( 95% CI 14, 68) %, respectively. As there were no significant differences in total n-6 PUFA and linoleic acid (LA) concentrations, the n-6:n-3 and LA: ALA ratios were lower in organic milk, by an estimated 71 (95% CI -122, -20)% and 93 (95% CI -116, -70) %. It is concluded that organic bovine milk has a more desirable fatty acid composition than conventional milk. Meta-analyses also showed that organic milk has significantly higher alpha-tocopherol and Fe, but lower I and Se concentrations. Redundancy analysis of data from a large cross-European milk quality survey indicates that the higher grazing/conserved forage intakes in organic systems were the main reason for milk composition differences.
AtıfScopus197WoS154OpenAlex212İncele - Derleme MakaleAçık Erişim2016Scopus SJRQ1Composition differences between organic and conventional meat: a systematic literature review and meta-analysis
Srednicka-Tober, Dominika; Baranski, Marcin; Seal, Chris; Sanderson, Roy; Benbrook, Charles; Steinshamn, Havard; Gromadzka-Ostrowska, Joanna; Rembialkowska, Ewa; Skwarlo-Sonta, Krystyna; Eyre, Mick
Demand for organic meat is partially driven by consumer perceptions that organic foods are more nutritious than non-organic foods. However, there have been no systematic reviews comparing specifically the nutrient content of organic and conventionally produced meat. In this study, we report results of a meta-analysis based on sixty-seven published studies comparing the composition of organic and non-organic meat products. For many nutritionally relevant compounds (e.g. minerals, antioxidants and most individual fatty acids (FA)), the evidence base was too weak for meaningful meta-analyses. However, significant differences in FA profiles were detected when data from all livestock species were pooled. Concentrations of SFA and MUFA were similar or slightly lower, respectively, in organic compared with conventional meat. Larger differences were detected for total PUFA and n-3 PUFA, which were an estimated 23 (95% CI 11, 35)% and 47 (95% CI 10, 84)% higher in organic meat, respectively. However, for these and many other composition parameters, for which meta-analyses found significant differences, heterogeneity was high, and this could be explained by differences between animal species/meat types. Evidence from controlled experimental studies indicates that the high grazing/forage-based diets prescribed under organic farming standards may be the main reason for differences in FA profiles. Further studies are required to enable meta-analyses for a wider range of parameters (e.g. antioxidant, vitamin and mineral concentrations) and to improve both precision and consistency of results for FA profiles for all species. Potential impacts of composition differences on human health are discussed.
AtıfScopus180WoS156OpenAlex225İncele - MakaleAçık Erişim2025Scopus SJRQ1Circulating Extracellular Vesicles as Putative Mediators of Cardiovascular Disease in Paediatric Chronic Kidney Disease
Behrens, Felix; Holle, Johannes; Chen, Chia-Yu; Ginsbach, Laura F.; Krause, Benjamin C.; Bruning, Ulrike; Kriegel, Fabian L.; Kaiser, Toralf; Szijarto, Istvan A.; Anandakumar, Harithaa
Cardiovascular disease (CVD) is the leading cause of mortality in chronic kidney disease (CKD). However, the pathogenesis of CVD in CKD remains incompletely understood. Endothelial extracellular vesicles (EC-EVs) have previously been associated with CVD. We hypothesized that CKD alters EV release and cargo, subsequently promoting vascular remodelling. We recruited 94 children with CKD, including patients after kidney transplantation and healthy donors, and performed EV phenotyping and functional EV analyses in the absence of age-related comorbidities. Plasma EC-EVs were increased in haemodialysis patients and decreased after kidney transplantation. Thirty microRNAs were less abundant in total CKD plasma EVs with predicted importance in angiogenesis and smooth muscle cell proliferation. In vitro, CKD plasma EVs induced transcriptomic changes in angiogenesis pathways and functionally impaired angiogenic properties, migration and proliferation in ECs. High shear stress, as generated by arterio-venous fistulas, and uremic toxins were considered as potential drivers of EV release, but only the combination increased EV generation from venous ECs. The resulting EVs recapitulated miRNA changes observed in CKD in vivo. In conclusion, CKD results in the release of EVs with altered miRNA profiles and anti-angiogenic properties, which may mediate vascular pathology in children with CKD. EVs and their miRNA cargo may represent future therapeutic targets to attenuate CVD in CKD.
AtıfWoS7OpenAlex5İncele - MakaleAçık Erişim2025Scopus SJRQ1Pedogenic evidence sheds light on the post-Roman pedo-sedimentological and human history of Tarsus, the Roman capital of CE 60, Cilicia, Mersin, Türkiye
Kapur, Selim; Akça, Erhan; Kadir, Selahattin; Previtali, Franco; Billor, Zeki; Zucca, Claudio; Casati, Enrico; Eren, Muhsin; Karagöz, Alptekin; Nazik, Atike
The ancient city of Tarsus is underlying a sediment of 400 cm where the contemporary Tarsus grew. The diffusely stratified layers of the deposited sediment from the Kydnos (Tarsus) river overlying the Roman Road excavation site located in the heart of the modern city. The sediment is laden with technogenic materials. The profile of the stratigraphic layers represents a Pedocomplex (PDC) and its horizons are the Pedomembers (PDMs). All the PDMs were described and sampled for physical, chemical, mineralogical, micromorphological, and thermoluminescense analyses seeking pedogenic evidences. The origin of PDC materials is a fluvial and/or lagoon environment (archaeologically predicted date, about 60 CE, and they are calcareous, high in available P and some are high in total phosphorus contents). They have been partially modified by human activity in a settlement area, thus bringing some historical evidence suggesting that the site was part of the growing city after its abandonment. Thin sections show a vigorous biological degradation of the organic residues in the PDMs along with occasional evidence of soil-forming processes. The preliminary conclusions were extracted from the results obtained through the newly formed hydroxyapatite (Hap) determined by micromorphology, therefore proposing the new suffix pi for the WRB soil naming system. Primary, high temperature and clay minerals together with TL analyses of the layers, were conducted to reveal the provenance and weathering phases of the horizons. The seeds recovered from an inhabited layer helped to interpret the food and medicinal habits of the local society and the contemporary presence of the lagoon.
AtıfWoS2OpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ2Comparative study of magnetic and electric quadrupole moments in boron (5B) isotopes
Ali, Ahmed H.; Tfiha, Amir D.; Zakaly, Hesham M. H.; Jarallah, Naz T.; Issa, Shams A. M.; Abdulqader, Abdulqader S.; Çelik, Necati; Bhuyan, M.
The magnetic moments and electric quadrupole moments of the B-5 isotopes were calculated using different nuclear interactions and sets of effective charges. Instead of relying on core polarization, the effective charges were adopted through a microscopic theoretical approach. The one-body density matrix (OBDM) elements for these isotopes were calculated using the NuShellX@MSU code. The calculations were carried out within the shell model framework, using both the p- and psd-model spaces (MS). These model spaces were selected for nuclei with proton number Z = 5 and neutron number N > 3. The theoretical results for magnetic and quadrupole moments were compared with available experimental data. Theoretical magnetic moments of the B-8,B-10,B-11,B-12,B-13 isotopes showed good agreement with experiment when using the p-MS with the pwt interaction, and the psd-MS with the psdmwk interaction. Similarly, the theoretical electric quadrupole moments reasonably well with the experimental values when using the p-MS with the pkuo interaction, and the psd-MS with the psdmwk interaction.
- MakaleAçık Erişim2023Scopus SJRQ2Internal deformation of continental blocks within converging plates: insights from the Ovacik Fault (Anatolia, Turkiye)
Zabci, Cengiz; Sançar, Taylan; Tikhomirov, Dmitry; Ivy-ochs, Susan; Vockenhuber, Christof; Friedrich, Anke M.; Yazici, Muge; Akçar, Naki
The active tectonics of Anatolia is mostly characterized by its westward motion with respect to Eurasia between the Hellenic subduction in the west and Arabia-Eurasia continental collision in the east. Although most of the deformation is suggested to be confined along Anatolias boundary elements, viz. the North and East Anatolian shear zones, recent studies indicate a higher magnitude of internal strain accumulation, especially along the parallel/subparallel strike-slip faults of its central province. We present the first morphochronology-based slip rate estimate for one of these strike-slip structures, the Ovacik Fault, by using cosmogenic 36Cl dating of offset fluvial deposits. At the Kcseler Site (39.3643 degrees N, 39.1688 degrees E), two faulted risers, bounding the alluvial fan with its subplanar surface (NF1/NF1') and the inset terrace tread (NF1/T2), are offset 19-24 and 15-22 m, respectively. The scattered surface ages and variability of 36Cl concentrations in depth profiles suggest strong evidence for inheritance in alluvial fan and terrace deposits; thus, we used modelled depth-profile ages for both surfaces. The modelled ages 8-10 ka for NF1 and 6-8 ka for T2 yield slip-rate estimates 2.4 +0.5/-0.4 mm/a and 2.8 +0.7/-0.7 mm/a, respectively, for the upper-tread reconstruction of the NF1/NF1'and the lower-tread reconstruction of the NF1/T2. Our results together with previous slip-rate estimates for other structures show a significant internal deformation for Anatolia, especially along its subparallel strike-slip faults. These secondary faults slice Anatolia into several pieces giving rise to the formation of the Malatya-Erzincan, Cappadocian, and Central Anatolian slices, where the geometry is strongly controlled by the distribution of the Tethyan accretionary complexes.
AtıfWoS2OpenAlex3İncele - MakaleYalnız künye2016Scopus SJRQ1A study to develop clinical decision rules for the use of radiography in wrist trauma: Karadeniz wrist rules
Karaca, Yunus; Turkmen, Suha; Cansu, Aysegul; Baki, Mehmet Emre; Eroglu, Oguz; Tatli, Ozgur; Gunaydin, Mucahit; Beyhun, Ercument; Gunduz, Abdulkadir; Eryigit, Umut
Introduction: The aim of this study was to evaluate patients presenting to the emergency department (ED) with wrist trauma using physical examination findings and functional tests and to identify findings with high sensitivity and specificity among the parameters assessed in patients with fracture in the wrist. The ultimate objective was thus to establish a reliable and widely usable clinical decision rule for determining the necessity of radiography in wrist trauma. Methods: This prospective, multicenter study was performed in 8 hospitals. The relation between radiologically determined fracture and clinical findings consisting of physical examination findings and functional tests was assessed in terms of whether or not these were markers of radiography requirement, with the aim of identifying predictive values for fracture. Results: A total of 603 eligible trauma patients presented to the participating EDs during the study period. Fracture was identified in 24.5% of patients (n= 148). The 4-way combination with the highest sensitivity was identified as axial compression and the positive distal radioulnar drawer test, and pain with radial deviation and dorsal flexion. Sensitivity at distal ulna palpation was added as a fifth parameter, and sensitivity and negative predictive value thus increased to 100%. Conclusion: With their 100% sensitivity and 100% negative predictive values, the Karadeniz wrist rules may represent a clinical decision rule that can be used in practice in EDs. If all 5 findings are negative, there is no indication for wrist radiography. (C) 2016 Elsevier Inc. All rights reserved.
AtıfWoS8OpenAlex11İncele - MakaleYalnız künye2023Scopus SJRQ1Managers' dispositions toward formal contracts: A cross-country examination
Stefanidis, Abraham; Banai, Moshe; Newburry, William; Fainshmidt, Stav; Richter, Ulf Henning; Schinzel, Ursula; Kong, Yin; Erkus, Ahmet; Shakirova, Svetlana; Ozbek, Mehmet Ferhat
This study integrates institutional and dispositional theories to develop a multilevel model predicting that managers' endorsement of formal contracts increases with the quality of formal institutions. This effect is contingent upon managerial dispositions of ethical idealism and interpersonal trust, which provide a morally driven override of uncertainty and a substitute source of certainty in business practices, respectively. We test our arguments on hand-collected data from 3,652 manager-negotiators in 16 countries. We find that managers endorse formal contracts when they are embedded in contexts with high quality contract enforcement institutions, but this effect diminishes substantially among ethically idealistic managers. These results suggest that an understanding of managers' reliance on formal contracts requires multilevel theory informed by how managerial dispositions interact with the formal institutional context.
AtıfScopus5WoS4OpenAlex5İncele - MakaleYayıncıda açık erişim2025Scopus SJRQ1Was the Formation of the North Anatolian Fault Influenced by the Aegean Extension?
Uysal, I. Tonguc; Karabacak, Volkan; Aykut, Tunahan; Ring, Uwe; Liu, Entao; Sancar, Taylan; Leonard, Nicole; Tong, Kui; Todd, Andrew J.; Temel, Abidin
The North Anatolian Fault (NAF), one of the most prominent plate boundary continental fault systems on Earth, facilitates the westward movement of the Anatolian microplate into the Aegean region. The temporal and spatial evolution of the NAF is important for understanding the mechanism of escape tectonics during plate interaction in active orogenic regions. The driving force(s) behind the movement of the NAF and the time period over which this occurred remain controversial. Our U-Pb and K-Ar dating of syntectonic minerals shows that a predecessor faulting initiated as early as similar to 40 Ma due to shortening along the Neo-Tethyan suture zone. Fault reactivations occurred at similar to 20 and 10 Ma synchronously in eastern and western Anatolia, suggesting that the NAF already existed by similar to 20 Ma. Our data also show that the westward motion of Anatolia was not only controlled by the Arabia-Eurasia collision in eastern Anatolia, but also by Aegean extension.
AtıfWoS7OpenAlex6İncele - MakaleAçık Erişim2026Scopus SJRQ1Inspiratory muscle training enhances jumping power and shooting performance in elite air pistol athletes
Aydin, Ahmet Serhat; Yilmaz, Coskun; Söyler, Mehmet; Güney, Gamze; Eyüboglu, Ender; Karakulak, Izzet; Ceylan, Tulay; Altug, Tolga; Burac, Daniela Giconda; Sahinler, Yunus
Background Inspiratory muscle training (IMT) has been shown to enhance respiratory efficiency, postural stabilization, and neuromuscular coordination in athletic populations. However, its effects in precision sports such as air pistol shooting remain insufficiently explored. This study investigated the impact of a 4-week IMT program on respiratory muscle strength, explosive lower-limb performance, reaction time, and shooting accuracy in competitive air pistol athletes. Methods Twenty trained male air pistol athletes (age 18-35 years) were randomly assigned to an IMT group (n = 10) or a control group (n = 10). The IMT group performed supervised inspiratory muscle training twice daily (30 breaths/session), six days per week, for four weeks, using a threshold-loading device set initially at 40% of maximal inspiratory pressure (MIP), with progressive overload applied weekly. Both groups maintained their regular shooting training routines. Pre- and post-intervention assessments included countermovement jump (CMJ) and squat jump (SJ) performance (OptoJump), visual and auditory reaction time (Cognitech), and shooting performance evaluated via the SCATT system. A two-way repeated-measures ANOVA (group & times; time) was used for statistical analysis. Results Significant group & times; time interactions were observed for CMJ height (p < 0.001, eta & sup2;p = 0.618), CMJ power (p = 0.007, eta & sup2;p = 0.345), SJ height (p = 0.050, eta & sup2;p = 0.184), and SJ power (p = 0.050, eta & sup2;p = 0.181), indicating meaningful improvements in explosive performance in the IMT group. Shooting accuracy demonstrated a large and statistically significant interaction effect (p < 0.001, eta & sup2;p = 0.532), with substantial improvement observed only in the IMT group. Reaction time variables showed favourable but non-significant trends (p > 0.05). Conclusion A short-term IMT intervention significantly enhanced lower-limb explosive performance and shooting accuracy in competitive air pistol athletes without altering overall training load. These findings suggest that IMT may represent an effective, low-cost adjunct strategy to improve neuromuscular stability and fine-motor precision in precision-sport athletes.
- MakaleAçık Erişim2016Scopus SJRQ1Regulators of mitochondrial complex I activity: A review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder
Duong, Angela; Che, Yi; Ceylan, Deniz; Pinguelo, Arsene; Andreazza, Ana C.; Young, L. Trevor; Berk, Michael
Phenomenologically, bipolar disorder (BD) is characterized by biphasic increases and decreases in energy. As this is a state-related phenomenon, identifying regulators responsible for this phasic dysregulation has the potential to uncover key elements in the pathophysiology of BD. Given the evidence suggesting mitochondrial complex I dysfunction in BD, we aimed to identify the main regulators of complex I in BD by reviewing the literature and using the published microarray data to examine their gene expression profiles. We also validated protein expression levels of the main complex I regulators by immunohistochemistry. Upon reviewing the literature, we found PARK-7, STAT-3, SIRT-3 and IMP-2 play an important role in regulating complex I activity. Published microarray studies however revealed no significant direction of regulation of STAT-3, SIRT-3, and IMP-2, but a trend towards downregulation of PARK 7 was observed in BD. Immunocontent of DJ-1 (PARK-7-encoded protein) were not elevated in post mortem prefrontal cortex from patients with BD. We also found a trend towards upregulation of DJ-1 expression with age. Our results suggest that DJ-1 is not significantly altered in BD subjects, however further studies are needed to examine DJ-1 expression levels in a cohort of older patients with BD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
AtıfWoS10OpenAlex12İncele
