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- MakaleAçık Erişim2026Scopus SJRQ1A multi-evidence computational and experimental strategy for Silene nerimaniae: combining phytochemical characterization, bioactivity assessment, and ADEFRank-HCT-116-based metabolite prioritization
Erharman, Ahmet; Yagi, Sakina; Uba, Abdullahi Ibrahim; Nikolic, Filip; Gasic, Uros; Acar, Mikail; Dogan, Nurettin; Koyuncu, Ismail; Yapici, Ismail; Gulcin, Ilhami
This study presents the first comprehensive evaluation of the phytochemical composition, antioxidant properties, enzyme inhibitory effects, and cytotoxic potential of Silene nerimaniae G.E.Gen & ccedil;, Kandemir & & Idot;.Gen & ccedil; (family Caryophyllaceae). Ethyl acetate, acetone, 70% acetone, and aqueous extracts were obtained from the aerial parts of the plant through maceration. Among the tested extracts, the acetone extract contained the highest total phenolic (24.37 mg GAE per g) and flavonoid (24.64 mg RE per g) contents. LC-MS analysis identified 52 bioactive constituents, including sugars, organic acids, phenolic acids, flavonoids, and fatty acids. The aqueous extract demonstrated the strongest radical scavenging activity against DPPH (23.02 mg TE per g) and ABTS (55.76 mg TE per g), as well as the highest Fe3+ reducing power (37.53 mg TE per g). In combination with the acetone extract, it also exhibited notable Cu2+ reducing activity (47.78 mg TE per g). Regarding enzyme inhibition, the ethyl acetate, acetone, and hydroacetone extracts displayed the strongest inhibitory activities against acetylcholinesterase (1.87 mg GALA per g), butyrylcholinesterase (2.92 mg GALA per g), and tyrosinase (60.44 mg KAE per g), respectively. All three extracts also inhibited alpha-amylase activity within the range of 0.73-0.77 mmol ACAE per g (p >= 0.05). In addition, the hydroacetone extract showed considerable inhibition of human carbonic anhydrase isoenzymes I (IC50 = 38.78 mu g mL-1) and II (IC50 = 19.59 mu g mL-1). The ethyl acetate extract exhibited the strongest cytotoxic effect against the colorectal cancer cell line HCT-116, with an IC50 value of 0.639 mu g mL-1 and a selectivity index of 1.7. To contextualize this HCT-116-associated activity at the metabolite level, an ADEFRank-HCT116 (abundance-domain-evidence fusion ranking) workflow was applied by integrating EtOAc abundance, HCT-116-oriented QSAR evidence, applicability-domain confidence, and structure-assignment reliability. This analysis prioritized diosmetin, luteolin, eriodyctiol, acacetin, and isorhamnetin as core candidates for structure-based follow-up. Molecular docking screening predicted favorable docking profiles for the prioritized candidates, while 100 ns molecular dynamics simulations were used to assess the dynamic stability of the representative luteolin-PI3K alpha, diosmetin-AKT1, and isorhamnetin-GSK-3 beta complexes. Taken together, these results indicate that S. nerimaniae may represent a valuable source of active compounds for various functional nutraceutical, cosmetic and pharmaceutical uses.
- MakaleAçık Erişim2026Scopus SJRQ1Comparison of plyometric repeated sprint and plyometric aerobic training on physical performance in youth soccer players
Selmi, Mohamed Amin; Hammami, Raouf; Ceylan, Halil Ibrahim; Duncan, Michael; Sassi, Radhouane Haj; Morgans, Ryland; Bayrakdaroglu, Serdar; Bragazzi, Nicola Luigi
High-intensity interval training (HIIT) and repeated-sprint sets (RSS) are established conditioning methods in soccer, yet their integration with plyometric training among highly trained youth soccer players remains underexplored. This study investigated the effects of an 8-week program combining plyometric training with either RSS (PLYO-RSS) or HIIT (PLYO-HIIT) on physical fitness in young soccer players. Twenty-nine male players (14-15 years) were randomly assigned to PLYO-RSS (n = 14) or PLYO-HIIT (n = 15). Both interventions lasted 20 minutes per session and replaced part of regular soccer training. Physical fitness assessments included countermovement jump (CMJ), 15-s repeated vertical jumps (15''RJ), five-jump test (5JT), 10 m and 30 m sprint, maximal aerobic speed (MAS), VO2max, and repeated sprint performance (total sprint time, best sprint, fatigue index). Physiological markers (lactate, rating of perceived exertion, and HRmax) were also monitored. Significant improvements over time were observed in muscle power, sprint speed, aerobic capacity, and repeated-sprint ability (p <= 0.001; eta & sup2;p = 0.339-0.489). However, no main effects or group & times; time interaction effects were observed, indicating no evidence of differential responses between the two training modes. In conclusion, integrating plyometric training with either RSS or HIIT effectively enhances physical fitness in highly trained youth soccer players, offering flexible options for training prescription.
- MakaleAçık Erişim2023Scopus SJRQ2Phylogenetic analysis based on the ITS, matK and rbcL DNA barcodes and comparison of chemical contents of twelve Paeonia taxa in Turkiye
Cetiz, Mehmet Veysi; Turumtay, Emine Akyuz; Burnaz, Nesibe Arslan; Özhatay, Fatma Neriman; Kaya, Erdal; Memon, Abdulrezzak; Turumtay, Halbay
BackgroudTwelve taxa of herbaceous Paeonia species were recorded in Turkiye. All definitions were performed morphologically and/or anatomically and there is no study based on DNA barcode sequences. Three barcode regions were sequenced to determine the phylogenetic relationships of Turkish Paeonia taxa. The chemical comparison of roots was also investigated.Methods and resultsThe taxons were collected between May and June 2021 from nine cities. Leaf materials were used for DNA isolation and ITS, matK and rbcL regions were amplified and sequenced. There was no difference among taxa in terms of rbcL sequences. But the ITS and matK regions distinguished 12 taxa and structured them in two groups. ITS region distinguished P. peregrina, P. arietina, and P. tenuifolia from other taxa, while matK region distinguished P. arietina and P. witmanniana from other taxa. Both barcode sequences actually showed that the registration of P. mascula subsp. arasicola was actually 100% similar to P. arietina. ITS was the most polymorphic region (n = 54) followed by matK (n = 9). These sequences could successfully discriminate Paoenia species from each other and diploid P. tenuifolia. The methanolic root (100 gr) extracts were examined for total phenolic and flavonoid content, and antioxidant activities. Significant variation was found for polyphenolic content, and antioxidant properties (TPC from 204.23 to 2343.89 mg, TFC from 7.73 to 66.16 mg, and FRAP from 523.81 to 4338.62 mg). SC50 values of ABTS and DPPH were ranged from 115.08 to 1115.52 mu g/ml and 73.83 to 963.59 mu g/ml, respectively.ConclusionIt was concluded that 11 of 12 taxa had differences in terms of ITS and matK sequences and these region must be used for the correct identification of Turkish Paeonia.
AtıfScopus7WoS7OpenAlex10İncele - MakaleAçık Erişim2015Scopus SJRQ1Distribution of β-Lactamase Genes Among Carbapenem-Resistant Klebsiella pneumoniae Strains Isolated From Patients in Turkey
Iraz, Meryem; Düzgün, Azer Ozad; Sandalli, Cemal; Doymaz, Mehmet Ziya; Akkoyunlu, Yasemin; Saral, Aysegul; Peleg, Anton Y.; Özgümüs, Osman Birol; Beris, Fatih Saban; Karaoglu, Hakan
Background: The emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management. We investigated the beta-lactamases in a group of carbapenem-resistant K. pneumoniae clinical isolates from Turkey. Methods: Thirty-seven strains of K. pneumoniae isolated from various clinical specimens were analyzed by antimicrobial susceptibility testing, PCR for the detection of p-lactamase genes, DNA sequencing, and repetitive extragenic palindronic (REP)- FOR analysis. Results: All 37 isolates were resistant to ampicillin, ampicillin/sulbactam, piperacillin, piperacillin/tazobactam, ceftazidime, cefoperazone/sulbactam, cefepime, imipenem, and meropenem. The lowest resistance rates were observed for colistin (2.7%), tigecycline (11%), and amikacin (19%). According to FOR and sequencing results, 98% (36/37) of strains carried at least one carbapenemase gene, with 32 (86%) carrying OXA-48 and 7 (19%) carrying NDM-1. No other carbapenemase genes were identified. All strains carried a CTX-M-2-like beta-lactamase, and some carried SHV- (97%), TEM- (9%), and CTX-M-1-like (62%) beta-lactamases. Sequence analysis of bla(TEM) genes identified a bla(TEM-166) with an amino acid change at position 53 (Arg53Gly) from bla(TEM-1b), the first report of a mutation in this region. REP-FOR analysis revealed that there were seven different clonal groups, and temporo-spatial links were identified within these groups. Conclusions: Combinations of beta-lactamases were found in all strains, with the most common being OXA-48, SHV, TEM, and CTX-M-type (76% of strains). We have reported, for the first time, a high prevalence of the NDM-1 (19%) carbapenemase in carbapenem-resistant K. pneumoniae from Turkey. These enzymes often co-exist with other beta-lactamases, such as TEM, SHV, and CTX-M beta-lactamases.
AtıfScopus55WoS46OpenAlex56İncele - MakaleAçık Erişim2024Scopus SJRQ1GIS-based multi-influencing factor (MIF) application for optimal site selection of solar photovoltaic power plant in Nashik, India
Rane, Nitin Liladhar; Günen, Mehmet Akif; Mallick, Suraj Kumar; Rane, Jayesh; Pande, Chaitanya B.; Giduturi, Monica; Bhutto, Javed Khan; Yadav, Krishna Kumar; Tolche, Abebe Debele; Alreshidi, Maha Awjan
The significant natural energy sources for reducing the global usage of fossil fuels are renewable energy (RE) sources. Solar energy is a crucial and reliable RE source. Site selection for solar photovoltaic (PV) farms is a crucial issue in terms of spatial planning and RE policies. This study adopts a Geographic Information System (GIS)-based Multi-Influencing Factor (MIF) technique to enhance the precision of identifying and delineating optimal locations for solar PV farms. The choice of GIS and MIF is motivated by their ability to integrate diverse influencing factors, facilitating a holistic analysis of spatial data. The selected influencing factors include solar radiation, wind speed, Land Surface Temperature (LST), relative humidity, vegetation, elevation, land use, Euclidean distance from roads, and aspect. The optimal sites of solar PV power plant delineated revealed that 'very low' suitability of site covering 4.866% of the study area, 'low' suitability of site 13.190%, 'moderate' suitability of site 31.640%, 'good' suitability of site 32.347%, and 'very good' suitability of site for solar PV power plant encompassing 17.957% of the study area. The sensitivity analysis results show that the solar radiation, relative humidity, and elevation are the most effective on the accuracy of the prediction. The validation of the results shows the accuracy of solar PV power plant prediction using MIF technique in the study area was 81.80%. The integration of GIS and MIF not only enhances the accuracy of site suitability assessment but also provides a practical implementation strategy. This research offers valuable insights for renewable energy policymakers, urban planners, and other stakeholders seeking to identify and develop optimal locations for solar energy power farms in their respective regions.
AtıfScopus62WoS49OpenAlex60İncele - MakaleYalnız künye2025Scopus SJRQ1Revealing the environmental influences of energy, transport, and pollution taxes on different transportation modes
Artan, Seyfettin; Pata, Ugur Korkut; Hayaloglu, Pinar; Cakir, Mehmet Ali; Recepoglu, Mursit; Cay Cakir, Sumeyra
The need for transportation is increasing with the effect of globalization in the developing economic system. The transportation sector, which is essential for economic development, may pose some threats to a sustainable environment. Although European countries have achieved various successes in reducing carbon emissions, they are struggling to reduce carbon dioxide (CO2) emissions from transportation. To overcome this difficulty, European countries are using various policy instruments such as environmental taxes. In this context, this study investigated the impact of disaggregated environmental taxes (pollution, energy, and transport), structural change, and institutional quality on transport-related carbon emissions (water, air, and road transport) in 24 European countries over the period 2008-2022. To this end, the study uses the novel half-panel jackknife estimation and the bias-corrected method of moments. The results indicate that there is no long-term relationship between environmental taxes and water transportation-related CO2 emissions. In contrast, structural changes and pollution taxes are effective in reducing road and air transport-related CO2 emissions. These results suggest that European countries should focus on reducing CO2 emissions through effective pollution taxes and encourage carbon taxes instead of energy and transport taxes, thereby supporting the European Green Deal's goal of becoming the first climate-neutral continent.
AtıfScopus6WoS5OpenAlex5İncele - MakaleYalnız künye2022Scopus SJRQ1Early Cambrian S-type granites in the Sakarya Zone, NE Turkey: A record for transition from subduction to post-collisional extension deduced from U-Pb zircon age and Nd-Hf isotopes
Karsli, Orhan; Sengün, Firat; Dokuz, Abdurrahman; Aydin, Faruk; Kandemir, Raif; Kristoffersen, Magnus; Santos, Jose Francisco; Hofmann, Mandy; Duygu, Levent
Cadomian realms have recently received much attention in the Alpine-Mediterranean orogenic belts, with discontinuous outcrops extending from the Alps to the Istanbul Zone, Menderes Massif, Taurides in Turkey and Iran as well. However, they have not been identified in the Sakarya Zone, northern Turkey to date. Here, we present, for the first time, zircon U-Pb geochronology, zircon Hf-isotopes and trace elements as well as whole-rock geochemistry and Nd-isotopes from the Karamese metagranitoid in the Yusufeli (Artvin) area, NE Turkey. The zircon U-Pb age data demonstrate that the Karamese metagranitoid intruded into the Precambrian basement units in the Early Cambrian (ca. 534-530 Ma). Zircon overgrowths in the Karamese metagranitoid interpreted as a result of metamorphic overprint yielded ages of 328 Ma. This age indicates that the Sakarya Zone experienced the Variscan metamorphic events at 328 Ma. The Early Cambrian metagranitoid shows that some rocks in the basement of the Sakarya Zone date back to Precambrian in age. The Karamese metagranitoid is an S-type granite, with high modal content of muscovite (similar to 10%). The samples show highly peraluminous [A/CNK = molar Al2O3/(CaO + K2O + Na2O) = 1.34-1.58] and medium-K calc-alkaline geochemical affinities. The Karamese metagranitoid displays low REE concentrations and a slight positive Eu anomaly and show slightly light REEs and LILEs enrichments, and HFSEs depletions. The samples have negative epsilon(Nd)(t) of -4.76 to -2.90 and epsilon(Hf) (t) of -4.75 to -1.08 values. These geochemical-isotopic characteristics reveal that the Karamase metagranitoid originated through fluid-absent muscovite dehydration melting of heterogeneous metasedimentary source rocks (mostly greywacke), with a minor input of juvenile mafic melt. We argue that the Early Paleozoic metagranitoids along the eastern Sakarya Zone is an expression of crustal thinning in the Cadomian orogenic belt in northern Gondwana, with the tectonic turnover from convergent margin to crustal extension possibly induced by break-off of Tornquist oceanic lithosphere which is a branch of Iapetus Ocean during Early Cambrian.
AtıfScopus16WoS14OpenAlex15İncele - MakaleYalnız künye2025Scopus SJRQ1Compositional variability and alteration dynamics of chromitites under greenschist metamorphism in the Kizildag ophiolite, southern Turkiye
Akmaz, Recep Melih; Uysal, Ibrahim; Su, Ben-Xun; Sen, Ahmet D.; Hu, Wen-Jun; Seitz, Hans-Michael; Mueller, Dirk; Eslami, Alireza
This study presents a complete alteration sequence in chromitites from the Kizildag ophiolite (southern T & uuml;rkiye), documenting three distinct chromite types that record processes related to Neotethyan subduction. Chromitites exhibit predominantly lenticular forms and occasionally banded textures, embedded within mantle peridotites and the mantle-crust transition zone, specifically harzburgite and dunite. Our analysis categorizes chromite grains into three groups: fresh, altered, and porous. Fresh chromites are characterized by high contents of Cr2O3 ranging from 42.69 to 57.08 wt% and Al2O3 from 12.46 to 25.34 wt%. In contrast, altered chromites, typically located along fractures or at the edges of fresh grains, show significant variability in chemical composition, with Cr2O3 content between 43.34 and 63.94 wt% and Al2O3 between 2.91 and 14.84 wt%. Porous chromites, distinguished by their porous structure, present Cr2O3 contents from 44.58 to 52.66 wt% and Al2O3 from 3.00 to 8.38 wt%. Notably, altered and porous chromites demonstrate substantial enrichments in Fe and trace elements such as Mn, Ni, Zn, Co, and Ga, indicating a shift due to metamorphic processes. The observed high Cr# (0.68-0.93) and low Mg# (0.25-0.65) values in rims of the altered and porous chromite further illustrate the metamorphic influence on chromite, with greenschist-facies conditions indicated by the Cr-Al-Fe3+ diagram at temperatures below 450 degrees C. The alteration dynamics reflect a progression that initiates with the olivine matrix and advances through reactions involving fresh chromites. This progression results in mass loss, the formation of chlorite, and the porous structures. Our findings contribute to the understanding of metamorphic alteration processes in chromitites and provide a detailed account of the geochemical trends (such as Fe/Mg exchange and trace element enrichment) that reflect greenschist-facies metamorphism. The evidence of chlorite formation and the prevalence of porous textures highlight the influence of metamorphic fluids over serpentinization, offering a model for chromite alteration in supra-subduction zones. This research elucidates the metamorphic history of chromitites in the Kizildag ophiolite.
AtıfScopus3WoS6OpenAlex4İncele - MakaleAçık Erişim2024Scopus SJRQ1Revisiting the depositional age and provenance characteristics of metasedimentary rocks from the basement units in the Central Pontides (N Turkey): New constraints for tectonic evolution of the southern Black Sea region
Cimen, Okay; Gucer, Mehmet Ali; Akal, Cueneyt; Goncueoglu, Mehmet Cemal; Arslan, Mehmet; Simonetti, Antonio; Karaoglan, Fatih
The pre -Jurassic tectonic evolution of the Central Pontides in northern Turkey is still poorly understood due to the lack of detailed geochemical and geochronological data from the basement units. Therefore, this study reports for the first time combined whole rock geochemistry, trace element data and U-Pb ages for detrital zircons, and Ar-Ar geochronological data from the metasedimentary rocks of the Devrekani Massif, Geme Complex, and the Serve & ccedil;ay Unit to better understand their provenance, depositional age characteristics, and tectonic evolutions. The detrital zircon U-Pb data of metasedimentary units from the Devrekani Massif, Geme Complex, and the Serve & ccedil;ay Unit yield ca. 191, 185 and 298 Ma maximum depositional ages (youngest age peaks), respectively. The Devrekani Massif is dominated by Permo-Carboniferous-aged detrital zircons (67 %), whereas Neoproterozoic and Devonian -aged detrital zircons are more common in the Geme Complex (47 %) and the Serve & ccedil;ay Unit (53 %). These distinct age distributions clearly indicate that the Devrekani Massif may has been deposited in a dissimilar location compared to the Geme Complex and the Serve & ccedil;ay Unit. Furthermore, in contrast to the Devrekani Massif, the source area of the metasedimentary rocks from the Geme Complex is comparable with that of the Serve & ccedil;ay Unit. Lastly, the obtained detrital zircon U-Pb and mica Ar-Ar ages suggest that the Devrekani Massif and the Geme Complex were deposited and metamorphosed during the Early and Middle Jurassic, respectively. The Serve & ccedil;ay Unit was deposited and metamorphosed in the Permian.
AtıfScopus5WoS6OpenAlex5İncele - Derleme MakaleAçık Erişim2024Scopus SJRQ1Decoding coffee cardiometabolic potential: Chemical composition, nutritional, and health relationships
Karagöz, Mustafa Fevzi; Koçyigit, Emine; Koçak, Tevfik; Sirin, Aycil Ozturan; Icer, Mehmet Arif; Agagündüz, Duygu; Coreta-Gomes, Filipe
Coffee is one of the most consumed beverages worldwide, recognized for its unique taste and aroma and for its social and health impacts. Coffee contains a plethora of nutritional and bioactive components, whose content can vary depending on their origin, processing, and extraction methods. Gathered evidence in literature shows that the regular coffee consumption containing functional compounds (e.g., polysaccharides, phenolic compounds, and melanoidins) can have potential beneficial effects on cardiometabolic risk factors such as abdominal adiposity, hyperglycemia, and lipogenesis. On the other hand, coffee compounds, such as caffeine, diterpenes, and advanced glycation end products, may be considered a risk for cardiometabolic health. The present comprehensive review provides up-to-date knowledge on the structure-function relationships between different chemical compounds present in coffee, one of the most prevalent beverages present in human diet, and cardiometabolic health.
AtıfScopus12WoS11İncele - MakaleAçık Erişim2023Scopus SJRQ1Ordovician S-type granites in the western Sakarya Zone, NW Turkey; linkage to a back-arc setting
Karsli, Orhan; Sengun, Firat; Aydin, Faruk; Moghadam, Hadi S.; Dokuz, Abdurrahman; Griffin, William L.; Saka, Simge Oguz; Zack, Thomas
Turkey's Early Paleozoic tectonic evolution has received much attention in recent years. Early Paleozoic intrusive rocks are mainly distributed across Europe, Turkey (Istanbul-Zonguldak Zone, Strandja Zone, and Tauride Block), and Iran. However, the Early Paleozoic rocks have not yet been identified in north Turkey's Sakarya Zone, and thus the Early Paleozoic paleogeography of the Sakarya Zone remains enigmatic. Here, we provide new field observations, petrography, geochemistry, and geochronology of the western Sakarya Zone to identify the nature, origin, and tectonic setting of the Ordovician magmatic rocks cropping out in the So center dot gut area (Bilecik, northwest Turkey). Our Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) U-Pb analyses on zircons suggest that the So center dot gut metagranites were emplaced at-484-461 Ma (except two zircons with ages of 490 and 494 Ma). There are abundant inherited zircon cores in the So center dot gut metagranites, with ages of >500 Ma to-2.2 Ga. The inherited Cadomian cores give concordant ages of 588 and 572 Ma. The So center dot gut metagranites are felsic and have high SiO2 (72-76 wt%) and K2O (4.1-5.3 wt%) contents, with high K2O/Na2O ratios (1.2-1.9), and low Mg# (17-35) values. The samples are Ca-poor (CaO = 0.52-0.68 wt%) and show peraluminous [A/CNK = molar Al2O3/(K2O + CaO + Na2O) = 1.15-1.28] and high-K calc-alkaline geochemical characters, with high modal content of muscovite (-10%), consistent with S-type compositions. The samples have low REE concentrations, with negative Eu anomalies. Ordovician zircon rims show epsilon Hf(t) values of +3.6 to-35.4, whereas inherited zircon cores have epsilon Hf(t) values of +33.9 to-26.1. Our data, in conjunction with previous studies, suggest that the So center dot gut metagranites were generated by fluid-absent muscovite-dehydration melting of metasediments accumulated in a back-arc setting. This back-arc basin was characterized by a denuded continental crust with abundant pelite-dominated sediments and minor input of juvenile mafic melts. Our results, combined with previously published data and paleogeographic reconstructions, allow us to conclude that the Ordovician S-type granites were formed by progressive back-arc extension and crustal thinning prompted by the rollback of the southward subducting oceanic-lithosphere slab. This led to the opening of the Rheic Ocean on the northern side of Gondwana in response to the final closure and termination of the Tornquist Ocean as a branch of the Iapetus Ocean. We argue that the Ordovician S-type granites from the northern side of Gondwana could signal significant crustal reworking away from any clear continental collision zone.
AtıfScopus15WoS14OpenAlex12İncele - MakaleAçık Erişim2026Scopus SJRQ1Chemical profiling, biological evaluation, and QSAR-informed metabolite prioritization of Hypericum ekerii: a first report on antioxidant, enzyme inhibitory, and cytotoxic activities
Zengin, Gokhan; Yagi, Sakina; Cetiz, Mehmet Veysi; Uba, Abdullahi Ibrahim; Nikolic, Filip; Gasic, Uros; Balos, Mehmet Maruf; Erharman, Ahmet; Dogan, Nurettin; Koyuncu, Ismail
Hypericum ekerii Y & uuml;ce and Ayta & ccedil;, first described in 2017, remains poorly characterized in terms of its phytochemical composition and biological properties. This study investigated aerial-part extracts of H. ekerii prepared with ethyl acetate, acetone, 70% acetone-water, and water. The hydroacetone extract showed the highest total phenolic and flavonoid contents. LC/MS analysis enabled the annotation of 99 constituents, including phenolic acids, flavonoids, xanthones, anthraquinones, and acylphloroglucinols. The hydroacetone extract exhibited the strongest radical-scavenging and reducing activities, whereas acetone and ethyl acetate extracts showed the highest metal-chelating capacity. In enzyme assays, hydroacetone was the most active extract against acetylcholinesterase, tyrosinase, and hCA II, while ethyl acetate showed greater inhibition of butyrylcholinesterase and hCA I. The aqueous extract was the most active against alpha-glucosidase, and hydroacetone and ethyl acetate showed comparable alpha-amylase inhibition. Cytotoxicity remained limited overall; the lowest IC50 value was observed for the ethyl acetate extract against HCT-116 cells (95.09 & micro;g mL-1), with weak selectivity (SI = 1.2). A QSAR-informed prioritization framework identified myricetin as the leading cross-layer candidate, p-coumaric acid as a target-specific priority metabolite, and ellagic acid, quercetin, and caffeic acid as antioxidant-priority candidates. Molecular docking supported favorable binding profiles for selected metabolites, while molecular dynamics simulations were used to assess the stability of representative complexes. Overall, H. ekerii appears to be a chemically diverse species with notable antioxidant and enzyme-inhibitory potential, providing a focused basis for future compound-level validation.
- MakaleYalnız künye2026Scopus SJRQ1Geochemical signature, detrital zircon U-Pb, and mica Ar-Ar age systematics from the Karadere Basement Unit of the İstanbul-Zonguldak Terrane (NW, Türkiye): evidence for an Avalonian-Cadomian active continental margin
Çimen, Okay; Gücer, Mehmet Ali; Göncüoglu, Mehmet Cemal; Akal, Cuneyt; Arslan, Mehmet; Simonetti, Antonio; Karaoglan, Fatih
The & Idot;stanbul-Zonguldak Terrane is located in northwest Anatolia and includes several outcrops with pre-Cambrian basement units. The Karadere Basement Unit represents the easternmost basement of this terrane and is composed of paragneiss, quartzite, and orthogneiss. The paragneiss and quartzite are cut by orthogneisses and disconformably overlain by Lower Ordovician to Middle Devonian cover units. Its pre-Cambrian to Palaeozoic tectonic evolution remains poorly understood, and therefore, this study reports whole-rock trace element signatures, detrital zircon U-Pb, and muscovite Ar-Ar age data for samples of paragneiss, quartzite, amphibolite, and orthogneiss. The whole-rock geochemical data indicate that the protoliths of the paragneiss and quartzite samples investigated here could have been derived from arc-related felsic magmatic units located in an active continental margin. The protoliths of amphibolites and orthogneiss samples are gabbro and granite, respectively, and their geochemical signatures are akin to those from continental arc igneous suites. The detrital zircon U-Pb data are characterized by predominantly Mesoproterozoic (84%) and lesser amount of Palaeoproterozoic and Neoproterozoic ages and suggest an early Tonian (youngest peak age of 915 +/- 18 Ma) maximum depositional age. Moreover, zircon U-Pb dating analyses from an orthogneiss sample yielded an age of 603 +/- 2 Ma, indicating the occurrence of mid-Ediacaran arc magmatism. This represents one of the oldest Ediacaran ages obtained from the metamagmatic basement rocks of the & Idot;stanbul-Zonguldak Terrane. Ar-Ar dating of muscovite from ortho- and paragneiss samples yielded ages of 533 +/- 25 Ma and 530 +/- 9 Ma, respectively, which are interpreted as early Cambrian cooling ages. Overall, the combined results reported here reveal that the Karadere Basement Unit is markedly different from NE African basement units but displays similarities to the basement rocks of both Avalonian and Amazonian terranes. It may have been formed and metamorphosed in an Avalonian-Cadomian active continental margin during the mid- to late Neoproterozoic and early Cambrian.
AtıfScopus1WoS1İncele - MakaleYalnız künye2022Scopus SJRQ2The Diagnostic Value of ischemia-modified albumin (IMA) and signal peptide-CUB-EGF domain-containing protein-1 (SCUBE-1) in an Experimental Model of Strangulated Mechanical Bowel Obstruction
Cekic, Arif Burak; Ozgen, Cekic Gonenc; Aygun, Ali; Pasli, Sinan; Ozer Yaman, Serap; Karahan Caner, Suleyman; Turedi, Suleyman; Acar, Sami; Tatli, Ozgur; Yulug, Esin
Background Mechanical bowel obstruction (MBO) is one of the principal pathologies requiring emergency surgery and a significant worldwide cause of morbidity. The identification of patients in whom bowel obstruction resolves spontaneously is important in terms of preventing unnecessary surgical interventions and future potential adhesions. The decision-making process is difficult in patients presenting without classic examination findings. Methods 36 female Sprague-Dawley rats randomly divided into six experimental groups. In Group 1, 3 and 5, laparotomy was performed, with blood and tissue specimens being collected after 1, 2 and 6 h, respectively. In Group 2, 4 and 6, the ileum segment was ligated following laparotomy, and blood and tissue specimens were collected after 1, 2 and 6 h, respectively. The ileum specimens were examined macroscopically, after which 1-cm sections were taken and examined in terms of histopathological changes. IMA and SCUBE-1 levels were determined for each group, and macro- and microscopic tissue examination findings were compared between the groups. Results Comparison within the groups exposed to waiting times of 1 h (groups 1 and 2), 2 h (groups 3 and 4) and 6 h (groups 5 and 6) revealed higher mean IMA and SCUBE-1 levels in rats undergoing ligation together with incision (groups 2, 4, and 6) compared to those undergoing laparotomy only (groups 1, 3, and 5). Correlation analysis was applied to determine the relationship between total scores obtained from histopathological examination and IMA and SCUBE-1 values. The analysis revealed strong, significant and positive correlation between histopathological examination scores and IMA (r=0.643, p=0.000) and SCUBE-1 (r=0.509, p=0.002) values. Conclusion The study findings showed that both IMA and SCUBE-1 values increased in a strangulated MBO model in rats. We think that IMA and SCUBE-1 values can be used as a markers of damage in the early period in strangulated MBO, and that the patient's surgery requirement can thus be determined in the early period.
AtıfWoS4OpenAlex7İncele - MakaleAçık Erişim2020Scopus SJRQ1Tracking the timing of Neotethyan oceanic slab break-off: Geochronology and geochemistry of the quartz diorite porphyries, NE Turkey
Karsli, Orhan; Dokuz, Abdurrahman; Aydin, Faruk; Uysal, Ibrahim; Sengün, Firat; Kandemir, Raif; Santos, Jose Francisco; Andersen, Tom
The initiation of the break-off of the northern branch of the Neotethyan oceanic lithosphere is an important but poorly understood event in the geology of the Sakarya Zone (SZ) in northeastern Turkey. Although it is wellknown that Latest Cretaceous intrusives (-70 Ma) and early Eocene adakitic magmatic rocks are present in the eastern SZ, the outcrops of the early Eocene non-adakitic rocks are very limited, and their tectono-magmatic evolution has not been studied. We describe a small outcrop of non-adakitic quartz diorite porphyry in the Kov area of the Gumushane region in northeastern Turkey. The genesis of these porphyries is significant in evaluating the syn-to post-collision-related magmatism. The LA-ICP-MS zircon U-Pb dating revealed that the Kov quartz diorite porphyries (KQDP) formed at ca. 50 Ma, coeval with adakitic rocks, and-20 Myr later than the slab rollback-related intrusive rocks. The KQDPs are calc-alkaline in composition and enriched in large ion lithophile elements (LILEs) and light rare earth elements (LREEs) and depleted in high field strength elements (HFSEs; e.g., Nb, Ta, Ti), with significant negative anomalies of Nb, Ta, and Ti but positive anomalies of Th, U, and Pb. Isotopic compositions of the samples show limited range of variation and slight enrichment of 87Sr/86Sr(t) (0.70489 to 0.70555), epsilon Nd(t) (-1.4 to -1.2) with TDM of 1.11 to 1.61 Ga. Pb isotopic ratios of the samples point to an enriched mantle source. They were likely crystallized from the melt that originated from an EM2-type spinel-facies subcontinental lithospheric mantle (SCLM), followed by the fractionation with insignificant crustal assimilation. The SCLM was metasomatically enriched, and the metasomatic agent was likely H2O-rich fluids rather than sediments released from subducting oceanic crust during the Late Cretaceous closure of the Neotethyan oceanic lithosphere. In conjunction with the geological background and previous data, we propose that the generation of the KQDPs resulted from a slab break-off event that caused ascending or infiltration of hot asthenosphere, triggering mantle melting. Such sporadic occurrences of the KQDPs, with coeval adakitic rocks in the SZ, are likely associated with the onset of extensional tectonics due to the earlier stage of slab break-off along the region during the early Eocene period.
AtıfScopus6WoS6OpenAlex7İncele - MakaleAçık Erişim2024Scopus SJRQ3Effects of different rest intervals in high intensity interval training programs on VO2max, body composition, and isokinetic strength and power
Kayhan, Recep Fatih; Bayrakdaroglu, Serdar; Ceylan, Halil Ibrahim; Eken, Ozgur; Bayrakdaroglu, Yesim; Badicu, Georgian; Al-Mhanna, Sameer Badri; Enoiu, Razvan-Sandu; Ardigo, Luca Paolo
The aim of this study was to evaluate the effect of 8 weeks of short and long rest running-based high-intensity training (HIIT) on body composition, isokinetic strength, and maximal oxygen uptake (VO2max). Nineteen physically active men were recruited to voluntarily participate in the study. The participants were grouped using the closed-envelope randomized method as HIIT with a short rest (HIITS, n = 9; age: 19.60 +/- 1.34 years) and HIIT with a long rest (HIITL, n = 10; age: 19.77 +/- 0.97). Pre and post the 8-week running-based HIIT program, body mass index and body fat % were measured and all subjects performed isokinetic strength tests to determine their hamstring (H)/quadriceps (Q) peak torque ratio and the peak power and peak work for their H and Q muscles. The participants also underwent a graded exercise test to determine their VO2max. Statistical analysis performed with One-Way Variance Analysis and Bonferroni correction post hoc tests. As a result of the study, there were no significant differences between the pre- and post-training isokinetic strength parameters for the H and Q of HIITL and HIITS at velocities of 60 and 240(degrees)s(-1). The VO2max did not change for HIITS training but the VO2max increased (p < 0.05) for HIITL training. In conclusion, that HIITL and HIITS programs for 8 weeks did not change the relative and absolute strength, force production and the VO2max, but the VO2max increased (p < 0.05) for HIITL training.
AtıfScopus9WoS9OpenAlex9İncele - MakaleAçık Erişim2025Scopus SJRQ2Low Serum and Urine Fetuin-A Levels and High Composite Dietary Antioxidant Index as Risk Factors for Kidney Stone Formation
Icer, Mehmet Arif; Koçak, Tevfik; Icer, Yusuf; Kocyigit, Emine; Agagündüz, Duygu; Gezmen-Karadag, Makbule; Yesil, Suleyman; Budán, Ferenc
Background: Fetuin-A prevents the precipitation of hydroxyapatite in supersaturated solutions of calcium and phosphate; however, its relationship with nephrolithiasis has yet to be clarified. The aim of this study was to investigate the protective and predictive roles of serum and urine fetuin-A levels in nephrolithiasis and their relationships with the composite dietary antioxidant index (CDAI). Methods: This study involved 75 adult patients with kidney stone disease and 71 healthy adults without kidney stone disease in the control group. Participants had specific anthropometric measurements taken, and three-day food records were kept. The CDAI was calculated by summing six standard antioxidants, including vitamins A, C, and E, manganese, selenium, and zinc, representing participants' antioxidant profile. In addition to some analyzed serum and urine parameters of the participants, fetuin-A levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Results: In patients with kidney stones, both serum and urine fetuin-A levels (676.3 +/- 160.14 ng/mL; 166.6 +/- 128.13 ng/mL, respectively) were lower than in the control group (1455.6 +/- 420.52 ng/mL; 2267.5 +/- 1536.78 ng/mL, respectively) (p < 0.00001). In contrast, the CDAI was higher in patients with kidney stones compared to those without kidney stones (p < 0.001). Besides, several dietary parameters had significant positive correlations with serum and/or urinary fetuin-A. Conclusions: The present study suggests that serum and urinary fetuin-A levels may serve as protective factors against kidney stones and could potentially be used as predictive markers for the development of nephrolithiasis. Furthermore, our results suggest that the CDAI above a certain level may increase the risk of stone formation and that some dietary parameters may affect the levels of this biomarker in serum and urine.
AtıfScopus6WoS5OpenAlex7İncele - MakaleAçık Erişim2025Scopus SJRQ2Production and quality assessment of functional crackers based on fruit seed oils
Barut, Yeliz Tekgul; Koç, Gulsah Caliskan; Akdogan, Arda; Erdogan, Selma Lubabe; Ergün, Ahsen Rayman; Altay, Kadriye; Rustagi, Sarvesh; Ramniwas, Seema; Pandiselvam, Ravi
Crackers are popular bakery products known for their crunchy texture and long shelf life. Typically made from leavened or unleavened dough with wheat flour, oil, water, and additives, crackers have undergone recipe enhancements to improve sensory and nutritional profiles. While many studies explore cracker and biscuit formulations, fruit seed oils remain underexplored. Fruit seeds, often discarded as waste, are rich in essential fatty acids, amino acids, and micronutrients. Oils from seeds such as grape, pomegranate, rosehip, and apricot have gained attention for their health benefits, which presents an opportunity for innovation in bakery products. This study evaluated the potential of incorporating various fruit seed oils (pomegranate, apricot kernel, grape, fig, and rosehip) into cracker formulations. Crackers were assessed for physicochemical properties, antioxidant activity, mineral content, texture, and sensory attributes, with sunflower oil as the control. Results showed that the addition of fruit seed oils significantly influenced cracker properties. Crackers with apricot kernel oil had the highest ash content (2.29 +/- 0.13%) and exhibited a more acidic character, as did those with grape seed oil. Moisture content decreased significantly when rosehip seed oil was used (P < 0.05). Grape seed oil yielded the highest water-holding capacity, while sunflower oil provided the highest oil-holding capacity. Crackers made with rosehip and apricot kernel oils demonstrated improved antioxidant properties. Using fruit seed oils not only enhances nutritional value (e.g. vitamins, minerals, antioxidants, and dietary fiber) but also reduces material waste, contributing to sustainability and better resource utilization.
AtıfScopus5WoS6OpenAlex6İncele - MakaleAçık Erişim2019Scopus SJRQ3Prostate volume effect on Gleason score upgrading in active surveillance appropriate patients
Çamur, Emre; Coskun, Alper; Kavukoglu, Ovunc; Can, Utku; Kara, Onder; Çamur, Arzu Develi; Sarica, Kemal; Narter, Kamil Fehmi
Introduction: Gleason Score (GS) upgrading rates in the literature are reported to be around 33-45%. The relationship between prostate volume and GS upgrading should be defined, aiming to reduce upgrading rates in patients with low risk groups who are eligible for active surveillance (AS) or minimally invasive treatment, by varying biopsy cores, or lengths of cores according to prostate volumes. In this regard, the aim of our study was to establish the relationship between prostate volume and GS upgrading. Materials and methods: We retrospectively analyzed the medical records of 78 patients, who were appropriate for AS between 2011-2016 at our hospital. Inclusion criteria were patient age under 65 years, PSA level under 10 ng/ml, GS (3 + 3) or (3 + 4), and 3 or less positive cores, clinical stages <= T2. GS increase in radical prostatectomy specimen was considered as 'upgrading' and in addition, score reported by biopsy as 3 + 4 but in surgical specimen as 4 + 3 were also considered as 'upgrading'. The effect of prostate volume on Gleason grade upgrading was examined by calculating upgrading rates separately for patients with prostate volume 30 ml or less, those with 30 to 60 ml, and those over 60 ml. Results: As a result of the analysis of the data, upgrading was seen in 35 (44.8%) of 78 patients included in the study. In the cohort mean prostate volume was 49.8 (+/- 26.3) ml. Twenty-two patients (28.2%) had prostate volume 30 ml or less, 34 (43.6%) 30 to 60 ml, and 22 (28.2%) 60 ml or more. The patients were divided into two groups as those with and without GS upgrading. Between the groups prostate volume and prostate volume range (0-30/31-60/> 60) were not significantly different (p value > 0.05). Conclusions: Gleason grade upgrading causes patients to be classified in a lower risk group than they actually are, and may lead to inappropriate treatment. This condition has a direct effect on the decision of active surveillance. Therefore, it is important to define the factors that can predict GS upgrading in active surveillance appropriate patients. In this study, we found that prostate volume has no significant effect on upgrading in active surveillance appropriate patients.
AtıfWoS6OpenAlex9İncele - MakaleAçık Erişim2026Scopus SJRQ2Long-term decline of Chernobyl-derived 137Cs in mosses and lichens from the Eastern Black Sea region of Türkiye
Çevik, Ugur; Çelik, Necati; Uzun, Kubra K.; Çelik, Ahmet; Koz, Bahadir; Özen, Songul A.; Yesilkanat, Cafer M.; Hacisalihoglu, Aylin; Özkalayci, Fatih; Kaya, Selim
This study presents the third consecutive assessment of 13 Cs activity concentrations in the same 50 moss (7 species) and lichen (2 species) sampling points in Ordu province, T & uuml;rkiye, one of the most heavily contaminated areas following the Chernobyl accident. Samples were collected from exactly the same locations used in the 1997 and 2007 studies and analyzed by high-resolution gamma spectrometry. In 2025, detectable 13 Cs was found in 14 of 30 moss sites (47%) and 3 of 20 lichen sites (15%). For samples below the minimum detectable activity (MDA), a value of MDA/2 (0.93 Bq kg-1) was substituted for lichens, while moss samples below the MDA were excluded from regression. The ecological half-life (Teco) for the 2007-2025 period was 4.38 +/- 1.05 years for mosses and 4.18 +/- 0.61 years for lichens. For mosses, this is nearly identical to the 1997-2007 mean (4.4 years), while for lichens it decreased from 5.6 to 4.18 years, suggesting a slight acceleration in environmental removal. All Teco values remain far shorter than the physical half-life of 13 Cs (30 years), confirming that environmental removal processes dominate over radioactive decay. Residual 13 Cs is concentrated in higher-altitude areas, reflecting the original deposition pattern and slower removal in cooler, more humid microenvironments. Nearly 39 years after the accident, the radiological risk posed by residual trace levels is negligible. This 28-year dataset provides one of the longest continuous records of 13 Cs in epiphytic bioindicators and serves as a valuable baseline for future contamination events.
